Human Brain Pharmacome Knowledge 0.0.4-dev

Mechanistic knowledge surrounding three biological phenomena: tau modification/aggregation, nicotinic receptor signalling, and proteostasis in the context of neurodegenerative disease

Authors
Rana Al Disi, Daniel Domingo-Fernández, Charles Tapley Hoyt, Kristian Kolpeja, Sandra Spalek, Esther Wollert, Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer SCAI, All rights reserved.

Summary

Number of Nodes
5339
Number of Edges
18422
Number of Citations
337
Number of Authors
1892
Network Density
6.46E-04
Number of Components
31
Number of Warnings
58

Nodes

Each node in a BEL graph is assigned a type. Most nodes are then identified with a namespace:identifier pair, or a definition based on other nodes as in the case of complexes, composites, and chemical reactions.

Edges

Topology

Bibliometrics

Statements

Reference BEL
pmid:30046111 tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) regulates deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(CHEBI:"amyloid-beta")
pmid:30046111 a(CHEBI:"amyloid-beta") negativeCorrelation act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30046111 a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30046111 a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29196815 a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29196815 a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 a(CHEBI:"amyloid-beta") increases path(MESH:"Alzheimer Disease")
pmid:19293145 sec(a(CHEBI:"amyloid-beta")) association path(MESH:"Alzheimer Disease")
pmid:19293145 a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease")
pmid:25514383 a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:11230871 a(CHEBI:"amyloid-beta") increases path(MESH:"Alzheimer Disease")
pmid:14556719 a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease")
pmid:30046111 a(CHEBI:"amyloid-beta") association a(MESH:Macrophages)
pmid:30232325 a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061)
pmid:21214928 a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061)
pmid:22122372 a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061)
pmid:22122372 a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061)
pmid:28745240 a(CHEBI:"amyloid-beta") decreases bp(GO:"calcium ion homeostasis")
pmid:28745240 a(CHEBI:"amyloid-beta") association bp(MESH:"Oxidative Stress")
pmid:28745240 a(CHEBI:"amyloid-beta") increases bp(MESH:"Oxidative Stress")
pmid:28745240 a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process")
pmid:28745240 a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process")
pmid:19293145 act(a(CHEBI:"amyloid-beta")) increases bp(GO:"apoptotic process")
pmid:28745240 a(CHEBI:"amyloid-beta") increases bp(GO:"JNK cascade")
pmid:28745240 a(CHEBI:"amyloid-beta") increases bp(GO:"Fas signaling pathway")
pmid:28745240 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 a(CHEBI:"amyloid-beta") increases complex(GO:"NF-kappaB complex")
pmid:28745240 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
pmid:25652642 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
pmid:25652642 a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex"))
pmid:25652642 a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex"))
pmid:25652642 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1)
pmid:25652642 a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1)
pmid:28745240 a(CHEBI:"amyloid-beta") decreases sec(a(PUBCHEM:16057918))
pmid:28745240 a(CHEBI:"amyloid-beta") increases complex(a(GO:"membrane attack complex"), p(HGNC:C5))
pmid:28745240 a(CHEBI:"amyloid-beta") increases p(HGNC:TNF)
pmid:29179999 a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF))
pmid:28019679 a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF))
pmid:28745240 a(CHEBI:"amyloid-beta") increases p(HGNC:APP)
pmid:18930136 a(CHEBI:"amyloid-beta") association deg(p(HGNC:APP))
pmid:28745240 a(CHEBI:"amyloid-beta") increases act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex"))
pmid:28745240 a(CHEBI:"amyloid-beta") regulates act(p(FPLX:PKC))
pmid:28745240 a(CHEBI:"amyloid-beta") regulates bp(HBP:"PI3K-Akt signaling pathway")
pmid:28745240 a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity)
pmid:25652642 a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity)
pmid:19293145 a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity)
pmid:19293145 act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity)
pmid:19293145 act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity)
pmid:19293145 act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity)
pmid:24590577 a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity)
pmid:21882945 a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity)
pmid:28745240 a(CHEBI:"amyloid-beta") increases a(CHEBI:"calcium(2+)")
pmid:28745240 a(CHEBI:"amyloid-beta") increases act(a(MESH:Microglia))
pmid:29179999 a(CHEBI:"amyloid-beta") increases bp(GO:"glial cell activation")
pmid:29179999 a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response")
pmid:16566606 a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response")
pmid:29179999 a(CHEBI:"amyloid-beta") increases sec(p(HGNC:IL1B))
pmid:29179999 a(CHEBI:"amyloid-beta") increases sec(p(HGNC:IL6))
pmid:29179999 a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB))
pmid:26010758 a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:"amyloid-beta") increases act(p(HGNC:NFKB1))
pmid:27288790 a(CHEBI:"amyloid-beta") increases act(p(HGNC:RELA))
pmid:25652642 a(CHEBI:"amyloid-beta") increases act(p(HGNC:APOE))
pmid:25652642 a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death")
pmid:21214928 a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death")
pmid:22122372 a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death")
pmid:22122372 a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death")
pmid:25652642 a(CHEBI:"amyloid-beta") increases p(HGNC:BAX)
pmid:19293145 a(CHEBI:"amyloid-beta") increases p(HGNC:BAX)
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAX))
pmid:25652642 a(CHEBI:"amyloid-beta") increases a(MESH:"I-kappa B Proteins")
pmid:29196815 a(CHEBI:"amyloid-beta") increases bp(GO:"positive regulation of neuron apoptotic process")
pmid:29196815 a(CHEBI:"amyloid-beta") increases complex(GO:"neurofibrillary tangle")
pmid:29196815 a(CHEBI:"amyloid-beta") increases path(MESH:Gliosis)
pmid:29196815 a(CHEBI:"amyloid-beta") increases path(MESH:"Neuroaxonal Dystrophies")
pmid:18650430 a(CHEBI:"amyloid-beta") increases bp(GO:"cell adhesion")
pmid:21214928 a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid")
pmid:21214928 a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid")
pmid:21214928 a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00027)
pmid:21214928 a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity")
pmid:21214928 a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity")
pmid:22122372 a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity")
pmid:22122372 a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity")
pmid:21214928 a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly")
pmid:22122372 a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly")
pmid:21214928 a(CHEBI:"amyloid-beta") association bp(GO:"MAPK cascade")
pmid:21214928 a(CHEBI:"amyloid-beta") association bp(GO:"ERK1 and ERK2 cascade")
pmid:21214928 a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses)
pmid:19293145 a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses)
pmid:21214928 a(CHEBI:"amyloid-beta") decreases bp(GO:memory)
pmid:25514383 a(CHEBI:"amyloid-beta") increases bp(GO:memory)
pmid:29758300 sec(a(CHEBI:"amyloid-beta")) increases bp(GO:memory)
pmid:22908190 a(CHEBI:"amyloid-beta") decreases bp(GO:memory)
pmid:21214928 a(CHEBI:"amyloid-beta") association bp(MESH:"Synaptic Transmission")
pmid:21214928 a(CHEBI:"amyloid-beta") decreases bp(GO:"long-term synaptic potentiation")
pmid:21214928 a(CHEBI:"amyloid-beta") association a(MESH:"Potassium Channels")
pmid:21214928 a(CHEBI:"amyloid-beta") increases bp(GO:"cell death")
pmid:21214928 a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA1), p(HGNC:APP))
pmid:21214928 sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA1), p(HGNC:APP))
pmid:21214928 a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA2), p(HGNC:APP))
pmid:21214928 sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA2), p(HGNC:APP))
pmid:21214928 a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA3), p(HGNC:APP))
pmid:21214928 sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA3), p(HGNC:APP))
pmid:21214928 a(CHEBI:"amyloid-beta") association a(CHEBI:"phorbol ester")
pmid:22122372 a(CHEBI:"amyloid-beta") decreases bp(GO:"learning or memory")
pmid:22122372 a(CHEBI:"amyloid-beta") increases a(HBP:HBP00038)
pmid:22122372 a(CHEBI:"amyloid-beta") increases a(HBP:HBP00018)
pmid:19293145 a(CHEBI:"amyloid-beta") association bp(GO:"synaptic transmission, cholinergic")
pmid:19293145 a(CHEBI:"amyloid-beta") association bp(GO:"synaptic transmission, cholinergic")
pmid:19293145 a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 a(CHEBI:"amyloid-beta") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 a(CHEBI:"amyloid-beta") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA7)
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7))
pmid:19293145 a(CHEBI:"amyloid-beta") association p(HGNC:CHRNA7)
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRNA7))
pmid:19293145 a(CHEBI:"amyloid-beta") causesNoChange p(HGNC:CHRNA7)
pmid:19293145 a(CHEBI:"amyloid-beta") causesNoChange act(p(HGNC:CHRNA7))
pmid:19293145 a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA7)
pmid:17009926 a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA7)
pmid:19293145 a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA4)
pmid:19293145 a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA4)
pmid:17009926 a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA4)
pmid:19293145 a(CHEBI:"amyloid-beta") increases bp(GO:"intracellular receptor signaling pathway")
pmid:19293145 act(a(CHEBI:"amyloid-beta")) association p(HGNC:FYN)
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(HGNC:FYN))
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(FPLX:PI3K))
pmid:19293145 a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph, Tyr))
pmid:19293145 act(a(CHEBI:"amyloid-beta")) association bp(GO:"calcium-mediated signaling")
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(HGNC:MAPK8))
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(HGNC:MAPK14))
pmid:19293145 a(CHEBI:"amyloid-beta") causesNoChange path(HBP:Neurodegeneration)
pmid:29758300 sec(a(CHEBI:"amyloid-beta")) decreases path(HBP:Neurodegeneration)
pmid:19293145 a(CHEBI:"amyloid-beta") decreases bp(MESH:"Neuronal Outgrowth")
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis))
pmid:19293145 a(CHEBI:"amyloid-beta") increases p(HGNC:MAPK1, pmod(Ph))
pmid:19293145 a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2)
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(p(HGNC:BCL2))
pmid:19293145 a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph))
pmid:26813123 a(CHEBI:"amyloid-beta") regulates p(HGNC:MAPT, pmod(Ph))
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(FPLX:JNK))
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(FPLX:ERK))
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAD))
pmid:19293145 a(CHEBI:"amyloid-beta") association bp(GO:"choline transport")
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7, var("p.L250T")))
pmid:19293145 a(CHEBI:"amyloid-beta") increases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))
pmid:19293145 a(CHEBI:"amyloid-beta") causesNoChange act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4)))
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA2), p(HGNC:CHRNB2)))
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)))
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRNA7, var("?")))
pmid:19293145 a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:nicotine))
pmid:19293145 a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA3)
pmid:19293145 a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna4)
pmid:19293145 a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna7)
pmid:19293145 a(CHEBI:"amyloid-beta") increases r(RGD:Chrna7)
pmid:19293145 a(CHEBI:"amyloid-beta") increases p(MGI:Chat)
pmid:19293145 a(CHEBI:"amyloid-beta") increases r(MGI:Chrna3)
pmid:17009926 a(CHEBI:"amyloid-beta") decreases a(CHEBI:acetylcholine)
pmid:17009926 a(CHEBI:"amyloid-beta") decreases sec(a(CHEBI:acetylcholine))
pmid:25514383 a(CHEBI:"amyloid-beta") increases act(a(CHEBI:acetylcholine))
pmid:17009926 a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRM))
pmid:26813123 a(CHEBI:"amyloid-beta") increases a(HBP:"amyloid-beta fibrils")
pmid:26813123 act(a(CHEBI:"amyloid-beta")) association act(p(HGNC:CHRM1))
pmid:24590577 a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRM1))
pmid:24590577 a(CHEBI:"amyloid-beta") decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
pmid:25514383 a(CHEBI:"amyloid-beta") increases act(a(HBP:"beta-2-containing nAChR"))
pmid:25514383 act(a(CHEBI:"amyloid-beta")) negativeCorrelation a(HBP:"alpha-7 beta-2 nAChR")
pmid:25514383 a(CHEBI:"amyloid-beta") regulates act(p(FPLX:CHRN))
pmid:25514383 a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRN))
pmid:25514383 a(CHEBI:"amyloid-beta") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 a(CHEBI:"amyloid-beta") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 a(CHEBI:"amyloid-beta") decreases bp(GO:"neuron cellular homeostasis")
pmid:25514383 a(CHEBI:"amyloid-beta") decreases a(GO:synapse)
pmid:22908190 a(CHEBI:"amyloid-beta") decreases act(a(GO:synapse))
pmid:26010758 a(CHEBI:"amyloid-beta") increases bp(GO:locomotion)
pmid:26010758 a(CHEBI:"amyloid-beta") decreases path(MESH:Anxiety)
pmid:26010758 a(CHEBI:"amyloid-beta") decreases path(MESH:"Interpersonal Relations")
pmid:26010758 a(CHEBI:"amyloid-beta") increases p(HGNC:AIF1)
pmid:26010758 a(CHEBI:"amyloid-beta") increases p(HGNC:PTPRC)
pmid:26010758 a(CHEBI:"amyloid-beta") increases p(HGNC:STAT3, pmod(Ph))
pmid:26010758 a(CHEBI:"amyloid-beta") increases r(HGNC:BACE1)
pmid:12428809 a(CHEBI:"amyloid-beta") association bp(GO:"axonal transport")
pmid:29758300 a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"TOR complex"))
pmid:29758300 a(CHEBI:"amyloid-beta") negativeCorrelation bp(GO:macroautophagy)
pmid:29758300 a(CHEBI:"amyloid-beta") increases p(HGNC:TARDBP, pmod(Ph))
pmid:29758300 a(CHEBI:"amyloid-beta") increases p(HGNC:TARDBP)
pmid:29758300 a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:PICALM)
pmid:29758300 a(CHEBI:"amyloid-beta") negativeCorrelation p(HGNC:SORL1)
pmid:14556719 a(CHEBI:"amyloid-beta") decreases act(complex(GO:"proteasome complex"))
pmid:22908190 a(CHEBI:"amyloid-beta") negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:22908190 a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:endocytosis)
pmid:22908190 a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:endocytosis)
pmid:22908190 a(CHEBI:"amyloid-beta") positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25784053 a(CHEBI:"amyloid-beta") decreases act(p(FPLX:Proteasome))
pmid:24027553 a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "17kD"))
pmid:24027553 a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "35kD"))
pmid:24027553 a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "24kD"))
pmid:30126037 a(CHEBI:"amyloid-beta") causesNoChange p(MGI:Cdkn2a)
pmid:26195256 a(CHEBI:"amyloid-beta") association a(MESH:Insulin)
pmid:26195256 a(CHEBI:"amyloid-beta") association bp(HBP:"perivascular drainage pathways")
pmid:26631930 a(CHEBI:"amyloid-beta") increases path(HBP:Excitotoxicity)
pmid:26631930 a(CHEBI:"amyloid-beta") increases path(HBP:Excitotoxicity)
pmid:29626319 a(CHEBI:"amyloid-beta") increases bp(GO:"response to oxidative stress")
pmid:29626319 a(CHEBI:"amyloid-beta") increases bp(HBP:"mitochondrial dysfunction")
pmid:29626319 a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:aging)
pmid:29626319 a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Diabetes Mellitus")
pmid:29626319 a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP2))
pmid:29626319 a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP3))
pmid:29626319 a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP9))
pmid:29626319 a(CHEBI:"amyloid-beta") decreases a(MESH:"Cerebrospinal Fluid")
pmid:29626319 deg(a(CHEBI:"amyloid-beta")) association p(HGNC:AQP4)
pmid:19251756 a(CHEBI:"amyloid-beta") positiveCorrelation complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO)))
pmid:29221819 a(CHEBI:"amyloid-beta") negativeCorrelation p(MGI:Dyrk1a)
pmid:25331948 a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Syk)
pmid:26118667 a(CHEBI:"amyloid-beta") negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:26118667 a(CHEBI:"amyloid-beta") increases p(INTERPRO:"Peptidase C2, calpain, catalytic domain")
pmid:22156579 a(CHEBI:"amyloid-beta") increases p(HGNC:MARK4)
pmid:22156579 a(CHEBI:"amyloid-beta") positiveCorrelation a(HBP:"Tau epitope, PHF1")
pmid:24401760 a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Bace1)
pmid:28855586 act(a(CHEBI:"amyloid-beta")) negativeCorrelation composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369)))
pmid:25378699 a(CHEBI:"amyloid-beta") increases p(RGD:Mapt, pmod(Sumo))
pmid:28500862 a(CHEBI:"amyloid-beta") positiveCorrelation p(HBP:"Tau aggregates")
pmid:28019679 a(CHEBI:"amyloid-beta") increases bp(GO:"innate immune response")
pmid:28019679 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:23702978 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:28019679 a(CHEBI:"amyloid-beta") increases a(CHEBI:"nitric oxide")
pmid:28019679 a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:28019679 a(CHEBI:"amyloid-beta") increases act(p(HGNC:CASP1))
pmid:23702978 a(CHEBI:"amyloid-beta") increases act(p(HGNC:NLRP3))
pmid:27314526 a(CHEBI:"amyloid-beta") association p(HGNC:NLRP3)
pmid:23702978 a(CHEBI:"amyloid-beta") increases act(p(FPLX:TLR))
pmid:24561250 a(CHEBI:"amyloid-beta") increases act(complex(GO:"inflammasome complex"))
pmid:24561250 a(CHEBI:"amyloid-beta") increases bp(GO:phagocytosis)
pmid:24561250 a(CHEBI:"amyloid-beta") decreases a(GO:lysosome)
pmid:30046111 bp(GO:phagocytosis) regulates deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:phagocytosis) association p(HGNC:TREM2)
pmid:29626319 bp(GO:phagocytosis) association p(HGNC:ABCA7)
pmid:29626319 bp(GO:phagocytosis) association p(HGNC:CD33)
pmid:29626319 bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:29626319 bp(GO:phagocytosis) decreases p(HGNC:MAPT)
pmid:24561250 bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:30046111 a(MESH:Microglia) regulates deg(a(CHEBI:"amyloid-beta"))
pmid:26195256 a(MESH:Microglia) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid"))
pmid:28745240 act(a(MESH:Microglia)) increases p(HGNC:TNF)
pmid:28745240 act(a(MESH:Microglia)) increases p(HGNC:IL1B)
pmid:28745240 act(a(MESH:Microglia)) increases p(HGNC:IL6)
pmid:28745240 act(a(MESH:Microglia)) increases p(HGNC:CXCL8)
pmid:28745240 act(a(MESH:Microglia)) increases bp(GO:"neuron death")
pmid:25652642 act(a(MESH:Microglia)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42")
pmid:23178521 a(MESH:Microglia) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:23383175 a(MESH:Microglia) positiveCorrelation a(MESH:Astrocytes)
pmid:23383175 a(MESH:Microglia) negativeCorrelation a(GO:"myelin sheath")
pmid:29202785 act(a(MESH:Microglia)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))
pmid:29202785 act(a(MESH:Microglia)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:29202785 act(a(MESH:Microglia)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:28528849 a(MESH:Microglia) regulates act(p(HBP:"Tau oligomers", var("p.Lys280del")))
pmid:29626319 a(MESH:Microglia) increases bp(GO:"immune response")
pmid:29626319 act(a(MESH:Microglia)) increases bp(GO:"cytokine production involved in inflammatory response")
pmid:29626319 act(a(MESH:Microglia)) increases bp(GO:"inflammatory response")
pmid:29626319 act(a(MESH:Microglia)) increases bp(HBP:Neurodegeneration)
pmid:29626319 act(a(MESH:Microglia)) increases bp(GO:phagocytosis)
pmid:29626319 a(MESH:Microglia) increases bp(GO:phagocytosis)
pmid:29238289 a(MESH:Microglia) increases p(HGNC:MAPT)
pmid:27314526 a(MESH:Microglia) increases p(HGNC:NLRP3)
pmid:27314526 a(MESH:Microglia) increases p(HGNC:P2RX7)
pmid:27314526 a(MESH:Microglia) increases p(HGNC:TLR4)
pmid:30046111 a(MESH:Monocytes) regulates deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta"))
pmid:30046111 a(MESH:Macrophages) regulates deg(a(CHEBI:"amyloid-beta"))
pmid:30046111 a(MESH:Macrophages) association a(CHEBI:"amyloid-beta")
pmid:30046111 a(HBP:HBP00018) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21718217 a(HBP:HBP00018) association path(MESH:"Alzheimer Disease")
pmid:30046111 a(HBP:HBP00018) decreases bp(GO:"neuron cellular homeostasis")
pmid:30046111 a(HBP:HBP00018) increases path(MESH:"Problem Behavior")
pmid:29196815 a(HBP:HBP00018) causesNoChange bp(GO:"neuron death")
pmid:29196815 a(HBP:HBP00018) causesNoChange bp(GO:"astrocyte activation")
pmid:22122372 a(HBP:HBP00018) association a(MESH:"Amyloid beta-Peptides")
pmid:22122372 a(HBP:HBP00018) increases path(MESH:"Plaque, Amyloid")
pmid:30046111 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00018)
pmid:21718217 path(MESH:"Alzheimer Disease") association a(HBP:HBP00018)
pmid:22040696 path(MESH:"Alzheimer Disease") increases a(HBP:HBP00018)
pmid:30046111 path(MESH:"Alzheimer Disease") association act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:30046111 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:30046111 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:19293145 path(MESH:"Alzheimer Disease") association sec(a(CHEBI:"amyloid-beta"))
pmid:19293145 path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta")
pmid:25514383 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:14556719 path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta")
pmid:29626319 path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 path(MESH:"Alzheimer Disease") increases a(CHEBI:"amyloid-beta")
pmid:10656250 path(MESH:"Alzheimer Disease") increases p(HGNC:BACE1)
pmid:21329555 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BACE1)
pmid:21329555 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA)
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA)
pmid:21329555 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation)
pmid:24027553 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation)
pmid:28745240 path(MESH:"Alzheimer Disease") association p(HGNC:IL6)
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL6)
pmid:28745240 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF)
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF)
pmid:29179999 path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:NFkappaB)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation act(p(FPLX:NFkappaB))
pmid:27288790 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"regulation of synaptic plasticity")
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"reactive oxygen species")
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B)
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B)
pmid:24561250 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B)
pmid:27314526 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18)
pmid:24561250 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18)
pmid:27314526 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18)
pmid:27314526 path(MESH:"Alzheimer Disease") association p(HGNC:IL18)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CXCL10)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TGFB1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:TGFB1)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"MAPK cascade")
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:pentosidine)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:GLAP)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PTGS2)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS2)
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-146a")
pmid:27288790 path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-155")
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA))
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation act(complex(GO:"NF-kappaB complex"))
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex")
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex")
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"HLA-DR Antigens")
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:"MIR9-1")
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR34A)
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR125B1)
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR146A)
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR155)
pmid:25652642 path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR339)
pmid:30444369 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HSD17B10)
pmid:30444369 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PRDX2))
pmid:30444369 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PRDX2)
pmid:30444369 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5)
pmid:24653673 path(MESH:"Alzheimer Disease") association p(HGNC:CDK5)
pmid:8282104 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5)
pmid:30444369 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SH3GL2)
pmid:29196815 path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases")
pmid:24511233 path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases")
pmid:24590577 path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases")
pmid:29196815 path(MESH:"Alzheimer Disease") decreases bp(GO:cognition)
pmid:19126755 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases bp(GO:cognition)
pmid:24511233 path(MESH:"Alzheimer Disease") association bp(GO:cognition)
pmid:24511233 path(MESH:"Alzheimer Disease") decreases bp(GO:cognition)
pmid:24590577 path(MESH:"Alzheimer Disease") decreases bp(GO:cognition)
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition)
pmid:19721446 path(MESH:"Alzheimer Disease") decreases bp(GO:cognition)
pmid:29196815 path(MESH:"Alzheimer Disease") increases bp(GO:"positive regulation of neuron apoptotic process")
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:19126755 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:19293145 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:19293145 path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid")
pmid:24590577 path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid")
pmid:25514383 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:19721446 path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid")
pmid:14556719 path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid")
pmid:22817713 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Amyloid beta-Peptides")
pmid:22122372 path(MESH:"Alzheimer Disease") association a(MESH:"Amyloid beta-Peptides")
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:28420982 path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:22817713 path(MESH:"Alzheimer Disease") association a(GO:"neurofibrillary tangle")
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00074)
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00074)
pmid:29196815 path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42")
pmid:19293145 path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 42")
pmid:26195256 path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 42")
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00076)
pmid:29196815 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NGFR)
pmid:21214928 path(MESH:"Alzheimer Disease") positiveCorrelation r(HBP:HBP00064)
pmid:21214928 path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:HBP00065)
pmid:21214928 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ADAM10)
pmid:21214928 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ADAM10))
pmid:21214928 path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:HBP00067)
pmid:22122372 path(MESH:"Alzheimer Disease") association bp(GO:"neurofibrillary tangle assembly")
pmid:22122372 path(MESH:"Alzheimer Disease") association bp(GO:"neuron death")
pmid:19293145 path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death")
pmid:17009926 path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death")
pmid:17009926 path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death")
pmid:24590577 path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death")
pmid:25514383 path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death")
pmid:22040696 path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death")
pmid:28420982 path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death")
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death")
pmid:22122372 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00064)
pmid:22122372 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00065)
pmid:19126755 path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR")
pmid:19721446 path(MESH:"Alzheimer Disease") decreases p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 path(MESH:"Alzheimer Disease") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 path(MESH:"Alzheimer Disease") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 path(MESH:"Alzheimer Disease") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:24590577 path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19721446 path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7)
pmid:19293145 path(MESH:"Alzheimer Disease") association p(HGNC:CHRNA7)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7)
pmid:19293145 path(MESH:"Alzheimer Disease") increases p(HGNC:CHRNA7)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7)
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7)
pmid:22040696 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7)
pmid:29191965 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CHRNA7)
pmid:19126755 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Dementia)
pmid:19293145 path(MESH:"Alzheimer Disease") association path(MESH:Dementia)
pmid:24511233 path(MESH:"Alzheimer Disease") association path(MESH:Dementia)
pmid:25514383 path(MESH:"Alzheimer Disease") association path(MESH:Dementia)
pmid:21718217 path(MESH:"Alzheimer Disease") increases path(MESH:Dementia)
pmid:14556719 path(MESH:"Alzheimer Disease") increases path(MESH:Dementia)
pmid:19126755 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"synaptic transmission, cholinergic")
pmid:24511233 path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic")
pmid:24511233 path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 path(MESH:"Alzheimer Disease") association bp(GO:"synaptic transmission, cholinergic")
pmid:24590577 path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic")
pmid:19126755 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles")
pmid:24590577 path(MESH:"Alzheimer Disease") association path(MESH:"Neurofibrillary Tangles")
pmid:24027553 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles")
pmid:19126755 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurogenic Inflammation")
pmid:19126755 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4)
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases bp(GO:memory)
pmid:24511233 path(MESH:"Alzheimer Disease") association bp(GO:memory)
pmid:22040696 path(MESH:"Alzheimer Disease") decreases bp(GO:memory)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases path(MESH:"Psychomotor Performance")
pmid:19293145 path(MESH:"Alzheimer Disease") association path(MESH:Death)
pmid:19293145 path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Neurofibrillary Tangles")
pmid:14556719 path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles")
pmid:19293145 path(MESH:"Alzheimer Disease") association a(HBP:"amyloid-beta aggregates")
pmid:25514383 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"amyloid-beta aggregates")
pmid:22817713 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"amyloid-beta aggregates")
pmid:19293145 path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine)
pmid:25514383 path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT))
pmid:19293145 path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT))
pmid:26813123 path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT))
pmid:24590577 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT)
pmid:25514383 path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT))
pmid:19293145 path(MESH:"Alzheimer Disease") decreases act(a(MESH:"Cholinesterase Inhibitors"))
pmid:19293145 path(MESH:"Alzheimer Disease") association g(HGNC:CHAT)
pmid:19293145 path(MESH:"Alzheimer Disease") association g(HGNC:ACHE)
pmid:19293145 path(MESH:"Alzheimer Disease") association a(HBP:"alpha-4 beta-2 nAChR")
pmid:11230871 path(MESH:"Alzheimer Disease") decreases a(HBP:"alpha-4 beta-2 nAChR")
pmid:19293145 path(MESH:"Alzheimer Disease") increases p(HGNC:FYN)
pmid:19293145 path(MESH:"Alzheimer Disease") increases p(HGNC:FYN)
pmid:19293145 path(MESH:"Alzheimer Disease") increases complex(p(HGNC:FYN), p(HGNC:MAPT))
pmid:24653673 path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT))
pmid:19293145 path(MESH:"Alzheimer Disease") association act(p(HGNC:INS))
pmid:19293145 path(MESH:"Alzheimer Disease") association bp(GO:"regulation of cytosolic calcium ion concentration")
pmid:19293145 path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1)
pmid:19293145 path(MESH:"Alzheimer Disease") association bp(GO:learning)
pmid:24511233 path(MESH:"Alzheimer Disease") association bp(GO:learning)
pmid:24511233 path(MESH:"Alzheimer Disease") decreases bp(GO:learning)
pmid:19293145 path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction")
pmid:24511233 path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction")
pmid:24511233 path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction")
pmid:26813123 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:27522251 path(MESH:"Alzheimer Disease") increases path(MESH:"Cognitive Dysfunction")
pmid:19293145 path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:APOE)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")
pmid:19293145 path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")
pmid:19293145 path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")
pmid:24511233 path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")
pmid:26813123 path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cholinergic Neurons")
pmid:24590577 path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")
pmid:24590577 path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")
pmid:19293145 path(MESH:"Alzheimer Disease") decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
pmid:19293145 path(MESH:"Alzheimer Disease") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3)
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3)
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3)
pmid:19293145 path(MESH:"Alzheimer Disease") causesNoChange r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNB4)
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")
pmid:19293145 path(MESH:"Alzheimer Disease") decreases p(HGNC:GABRB3)
pmid:19293145 path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna7)
pmid:25881725 path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Chrna7)
pmid:19293145 path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna4)
pmid:24511233 path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders")
pmid:24511233 path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders")
pmid:24511233 path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders")
pmid:24511233 path(MESH:"Alzheimer Disease") increases path(MESH:Depression)
pmid:26813123 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Depression)
pmid:24511233 path(MESH:"Alzheimer Disease") increases path(MESH:Anxiety)
pmid:24511233 path(MESH:"Alzheimer Disease") association bp(MESH:Aging)
pmid:17009926 path(MESH:"Alzheimer Disease") association p(FPLX:CHRN)
pmid:17009926 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:CHRN))
pmid:17009926 path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN)
pmid:17009926 path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN)
pmid:25514383 path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRN)
pmid:11230871 path(MESH:"Alzheimer Disease") association p(FPLX:CHRN)
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN)
pmid:17009926 path(MESH:"Alzheimer Disease") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7))
pmid:26813123 path(MESH:"Alzheimer Disease") increases deg(a(MESH:"Basal Nucleus of Meynert"))
pmid:26813123 path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Basal Nucleus of Meynert")
pmid:26813123 path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Apathy)
pmid:26813123 path(MESH:"Alzheimer Disease") association p(HGNC:ACHE)
pmid:11230871 path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE))
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ACHE))
pmid:11230871 path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE))
pmid:26813123 path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:rivastigmine)
pmid:26813123 path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q"))
pmid:24590577 path(MESH:"Alzheimer Disease") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:19721446 path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:25514383 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)
pmid:29758300 path(MESH:"Alzheimer Disease") association p(HGNC:MAPT)
pmid:14556719 path(MESH:"Alzheimer Disease") association p(HGNC:MAPT)
pmid:24027553 path(MESH:"Alzheimer Disease") association p(HGNC:MAPT)
pmid:24027553 path(MESH:"Alzheimer Disease") association p(HGNC:MAPT)
pmid:27574109 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)
pmid:27574109 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)
pmid:30126037 path(MESH:"Alzheimer Disease") association p(HGNC:MAPT)
pmid:22419736 path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:MAPT)
pmid:28420982 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)
pmid:28420982 path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT)
pmid:28420982 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)
pmid:26631930 path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines"))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT)
pmid:25514383 path(MESH:"Alzheimer Disease") negativeCorrelation a(GO:synapse)
pmid:22908190 path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse))
pmid:22908190 path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse))
pmid:25514383 path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"White Matter")
pmid:26195256 path(MESH:"Alzheimer Disease") association a(MESH:"White Matter")
pmid:25514383 path(MESH:"Alzheimer Disease") negativeCorrelation a(HP:"cholinergic neuron")
pmid:25514383 path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRN))
pmid:25514383 path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRM))
pmid:25514383 path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN))
pmid:11230871 path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN))
pmid:25514383 path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRM))
pmid:25514383 path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRM)
pmid:25514383 path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:CHRNA7), p(HGNC:FLNA))
pmid:21718217 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00030)
pmid:21718217 path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:ARG1)
pmid:21718217 path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHI3L1)
pmid:21718217 path(MESH:"Alzheimer Disease") association p(HBP:HBP00030)
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"alpha-4-containing nAChR")
pmid:11230871 path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"alpha-7-containing nAChR")
pmid:11230871 path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHRNA7)
pmid:11230871 path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA3)
pmid:11230871 path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA4)
pmid:19721446 path(MESH:"Alzheimer Disease") decreases a(MESH:Neurons)
pmid:19721446 path(MESH:"Alzheimer Disease") decreases path(MESH:"Memory, Episodic")
pmid:26837465 path(MESH:"Alzheimer Disease") increases complex(p(HGNC:ESR1), p(HGNC:MAPT))
pmid:21787755 path(MESH:"Alzheimer Disease") association a(HBP:AβOs)
pmid:28901280 path(MESH:"Alzheimer Disease") association p(MESH:"Receptors, Nicotinic")
pmid:23178521 path(MESH:"Alzheimer Disease") increases p(MGI:Il6)
pmid:23178521 path(MESH:"Alzheimer Disease") increases p(MGI:Tnf)
pmid:23178521 path(MESH:"Alzheimer Disease") increases p(MGI:Stat3, pmod(Ph))
pmid:22020111 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"protein aggregates")
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:AGRN)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:ANP32A)
pmid:24653673 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A)
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:BAX)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:BGN)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:BRCA1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:CADPS2)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:CAPN1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:CCNB1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:CDK1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:CDK2)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:CDKN2A)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:CXCR4)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:EIF4EBP1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:FOLH1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:HOMER1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:HRH1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:IGF2)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:IGFBP2)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:LDLR)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:MAOA)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:NEFH)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:NPDC1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:NRGN)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:PREP)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:PROS1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:SELENBP1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:TAGLN)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:TUBB3)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:VKORC1)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:CANX)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:GCNT2)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE)
pmid:30116051 path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:MMP1)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:NFE2L2)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:NR3C1)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:PPARA)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:SLC6A6)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:SYVN1)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:TSHZ1)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:TXN)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:ACLY)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:ATAD2)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1)
pmid:29758300 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:BECN1)
pmid:29758300 path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:DHCR24)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:FGF2)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:HTRA1)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKCE)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKDC)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:SCD)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:TUBB)
pmid:22020111 path(MESH:"Alzheimer Disease") decreases p(HGNC:UNG)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:ATP1A1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:CTSD)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:GLRX)
pmid:22020111 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:GLRX)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:HMOX1)
pmid:22020111 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HMOX1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:IL6R)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:NPTX1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:NQO1)
pmid:22020111 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NQO1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:PHF1)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCD)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:RANBP9)
pmid:22020111 path(MESH:"Alzheimer Disease") increases p(HGNC:SOD1)
pmid:22020111 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SOD1)
pmid:22020111 path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress")
pmid:23454242 path(MESH:"Alzheimer Disease") increases p(HGNC:SET)
pmid:24653673 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET)
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET)
pmid:23454242 path(MESH:"Alzheimer Disease") decreases act(p(FPLX:PPP2))
pmid:22299660 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2))
pmid:22299660 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2))
pmid:24653673 path(MESH:"Alzheimer Disease") association p(HGNC:GSK3B)
pmid:24653673 path(MESH:"Alzheimer Disease") association a(MESH:"Receptors, N-Methyl-D-Aspartate")
pmid:24653673 path(MESH:"Alzheimer Disease") association p(HGNC:GRM5)
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CA)
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA)
pmid:22299660 path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA)
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CA)
pmid:26631930 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PPP2CA))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CB)
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB)
pmid:22299660 path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB)
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CB)
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R2C)
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R5E)
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me))
pmid:24653673 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET, frag("?"))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PTPA)
pmid:24653673 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:22253473 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:8282104 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:24027553 path(MESH:"Alzheimer Disease") regulates p(HGNC:MAPT, pmod(Ph))
pmid:29191965 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:29191965 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:29311797 path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Ph))
pmid:26458742 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:27373205 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:22817713 path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph))
pmid:12428809 path(MESH:"Alzheimer Disease") association a(HBP:"straight filaments")
pmid:12428809 path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau")
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau")
pmid:12428809 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport")
pmid:22908190 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport")
pmid:12428809 path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
pmid:21882945 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 189))
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:26458742 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:29191965 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:22419736 path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:28420982 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:26458742 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:22419736 path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:26458742 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:29191965 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:29758300 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22299660 path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C)
pmid:22299660 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A)
pmid:22299660 path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C, pmod(Me, Leu, 309))
pmid:22299660 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ICMT)
pmid:22299660 path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:PPP2C, pmod(Ph, Tyr, 307))
pmid:25437566 path(MESH:"Alzheimer Disease") decreases p(HGNC:HSP90AB1)
pmid:25437566 path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA8)
pmid:25437566 path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA14)
pmid:25437566 path(MESH:"Alzheimer Disease") decreases p(HGNC:TCP1)
pmid:27491084 path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:27491084 path(MESH:"Alzheimer Disease") increases p(HGNC:HSPB1)
pmid:27491084 path(MESH:"Alzheimer Disease") increases p(HGNC:CRYAB)
pmid:27491084 path(MESH:"Alzheimer Disease") increases p(FPLX:HSPB)
pmid:29758300 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy)
pmid:29758300 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy)
pmid:29758300 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy)
pmid:29758300 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy)
pmid:25784053 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy)
pmid:29758300 path(MESH:"Alzheimer Disease") increases complex(a(GO:autophagosome), a(HBP:"dystrophic neurite"))
pmid:29758300 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:autophagy)
pmid:22908190 path(MESH:"Alzheimer Disease") association bp(GO:autophagy)
pmid:22908190 path(MESH:"Alzheimer Disease") association bp(GO:autophagy)
pmid:29758300 path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autolysosome)
pmid:23528736 path(MESH:"Alzheimer Disease") increases a(GO:autolysosome)
pmid:29758300 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process")
pmid:22908190 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process")
pmid:23528736 path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal protein catabolic process")
pmid:29758300 path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1, var("?"))
pmid:29758300 path(MESH:"Alzheimer Disease") increases a(GO:lysosome)
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:lysosome)
pmid:22908190 path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:lysosome))
pmid:29758300 path(MESH:"Alzheimer Disease") increases a(GO:autophagosome)
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome)
pmid:18930136 path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome)
pmid:18930136 path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome)
pmid:29758300 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SNCA)
pmid:29758300 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis)
pmid:22908190 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis)
pmid:22908190 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis)
pmid:29758300 path(MESH:"Alzheimer Disease") association a(HBP:"alpha-synuclein aggregates")
pmid:29758300 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"alpha-synuclein aggregates")
pmid:29758300 path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:ceramide)
pmid:29758300 path(MESH:"Alzheimer Disease") association p(HGNC:TFEB)
pmid:29758300 path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?"))
pmid:29758300 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BIN1)
pmid:29758300 path(MESH:"Alzheimer Disease") association p(HGNC:VPS35, var("?"))
pmid:29758300 path(MESH:"Alzheimer Disease") association p(HGNC:SORL1)
pmid:29758300 path(MESH:"Alzheimer Disease") increases bp(GO:mitophagy)
pmid:14556719 path(MESH:"Alzheimer Disease") decreases bp(GO:"short-term memory")
pmid:14556719 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA1))
pmid:14556719 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA2))
pmid:14556719 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:29626319 path(MESH:"Alzheimer Disease") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PRKN)
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ub))
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1")
pmid:23528736 path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1")
pmid:22908190 path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1)
pmid:22908190 path(MESH:"Alzheimer Disease") association p(HGNC:UBQLN1)
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBQLN1, var("?"))
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB7A)
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB5A)
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB4A)
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"dystrophic neurite")
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?"))
pmid:22908190 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?"))
pmid:22908190 path(MESH:"Alzheimer Disease") association g(HBP:"APOE e4")
pmid:25784053 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:Proteasome))
pmid:30145931 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:17403556 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:25374103 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:8282104 path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:ERK)
pmid:8282104 path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:GSK3)
pmid:30116051 path(MESH:"Alzheimer Disease") decreases p(HGNC:SIRT1)
pmid:29540553 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SIRT1))
pmid:30116051 path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:PSEN1, var("?"))
pmid:26195256 path(MESH:"Alzheimer Disease") association g(HGNC:PSEN1, var("?"))
pmid:30116051 path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"selenium(2+)")
pmid:30116051 path(MESH:"Alzheimer Disease") increases act(p(HGNC:ABL1))
pmid:30116051 path(MESH:"Alzheimer Disease") decreases p(HGNC:MME)
pmid:29024336 path(MESH:"Alzheimer Disease") increases path(MESH:"Proteostasis Deficiencies")
pmid:29215007 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("?"))
pmid:24027553 path(MESH:"Alzheimer Disease") association p(HGNC:PIN1)
pmid:24027553 path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:Microvessels))
pmid:24027553 path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:"Cerebrospinal Fluid"))
pmid:24027553 path(MESH:"Alzheimer Disease") association bp(HBP:"APP processing")
pmid:24027553 path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2))
pmid:24027553 path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP3))
pmid:24027553 path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP6))
pmid:24027553 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasomal protein catabolic process")
pmid:24027553 path(MESH:"Alzheimer Disease") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome))
pmid:24027553 path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:Autophagy)
pmid:24027553 path(MESH:"Alzheimer Disease") decreases bp(MESH:Autophagy)
pmid:24027553 path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Lysosomes)
pmid:27574109 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"3R tau")
pmid:27574109 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"4R tau")
pmid:27574109 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers")
pmid:27574109 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers")
pmid:25887395 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers")
pmid:28420982 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers")
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers")
pmid:22817713 path(MESH:"Alzheimer Disease") increases a(HBP:"Tau oligomers")
pmid:27574109 path(MESH:"Alzheimer Disease") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT))
pmid:21734277 path(MESH:"Alzheimer Disease") association act(p(HBP:"6D tau", frag("2_18")))
pmid:21734277 path(MESH:"Alzheimer Disease") association act(p(HBP:"6D tau", frag("2_18")))
pmid:23528736 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBB)
pmid:23528736 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBC)
pmid:23528736 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBA52)
pmid:23528736 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RPS27A)
pmid:23528736 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes")
pmid:23528736 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2")
pmid:23528736 path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1, var("?"))
pmid:23528736 path(MESH:"Alzheimer Disease") decreases bp(MESH:Proteolysis)
pmid:23528736 path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes)
pmid:29988016 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates")
pmid:27373205 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates")
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates")
pmid:22817713 path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates")
pmid:21882945 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:21882945 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BAG1)
pmid:30126037 path(MESH:"Alzheimer Disease") association bp(MESH:"Cerebrovascular Circulation")
pmid:22419736 path(MESH:"Alzheimer Disease") increases p(HGNC:AK1)
pmid:22419736 path(MESH:"Alzheimer Disease") increases p(HGNC:AK1)
pmid:22419736 path(MESH:"Alzheimer Disease") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172))
pmid:29191965 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:28877763 path(MESH:"Alzheimer Disease") increases bp(GO:"microglial cell activation")
pmid:28420982 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:29311797 path(MESH:"Alzheimer Disease") isA path(MESH:Tauopathies)
pmid:29311797 path(MESH:"Alzheimer Disease") decreases p(HGNC:PPID)
pmid:29311797 path(MESH:"Alzheimer Disease") increases p(HGNC:FKBP5)
pmid:29311797 path(MESH:"Alzheimer Disease") decreases p(HGNC:FKBP4)
pmid:29311797 path(MESH:"Alzheimer Disease") decreases act(p(HGNC:PPP5C))
pmid:29311797 path(MESH:"Alzheimer Disease") association p(HGNC:STUB1)
pmid:29311797 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AHSA1)
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 68))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 69))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 71))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 113))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 123))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 153))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 175))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 184))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 185))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 191))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 197))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 208))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 210))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 237))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 238))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 258))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 289))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 403))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 409))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 435))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 427))
pmid:26751493 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 433))
pmid:26195256 path(MESH:"Alzheimer Disease") increases p(HGNC:APP)
pmid:26195256 path(MESH:"Alzheimer Disease") association g(HGNC:PSEN2, var("?"))
pmid:26195256 path(MESH:"Alzheimer Disease") association g(HGNC:APP, var("?"))
pmid:26195256 path(MESH:"Alzheimer Disease") association path(MESH:Aging)
pmid:26195256 path(MESH:"Alzheimer Disease") association p(HBP:"APOE e4")
pmid:26195256 path(MESH:"Alzheimer Disease") association p(HGNC:TREM2)
pmid:26195256 path(MESH:"Alzheimer Disease") association p(HGNC:CLU)
pmid:26195256 path(MESH:"Alzheimer Disease") association p(HGNC:PICALM)
pmid:29626319 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM)
pmid:27260836 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM)
pmid:26195256 path(MESH:"Alzheimer Disease") association path(MESH:"Cardiovascular Diseases")
pmid:26195256 path(MESH:"Alzheimer Disease") association path(MESH:"Diabetes Mellitus")
pmid:26195256 path(MESH:"Alzheimer Disease") association path(MESH:Hypertension)
pmid:26195256 path(MESH:"Alzheimer Disease") association path(MESH:"Craniocerebral Trauma")
pmid:26195256 path(MESH:"Alzheimer Disease") association path(MESH:"Sleep Initiation and Maintenance Disorders")
pmid:26195256 path(MESH:"Alzheimer Disease") association path(MESH:"Pick Disease of the Brain")
pmid:26195256 path(MESH:"Alzheimer Disease") association a(MESH:"Prefrontal Cortex")
pmid:26195256 path(MESH:"Alzheimer Disease") association a(MESH:"Cerebral Cortex")
pmid:26195256 path(MESH:"Alzheimer Disease") association a(MESH:"Cerebral Ventricles")
pmid:26195256 path(MESH:"Alzheimer Disease") decreases bp(GO:"glucose metabolic process")
pmid:26195256 path(MESH:"Alzheimer Disease") decreases a(MESH:Brain)
pmid:26195256 path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 40")
pmid:26195256 path(MESH:"Alzheimer Disease") decreases p(MESH:Neprilysin)
pmid:26195256 path(MESH:"Alzheimer Disease") increases p(HGNC:MMP2)
pmid:26195256 path(MESH:"Alzheimer Disease") decreases p(HGNC:LRP1)
pmid:26195256 path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1)
pmid:29626319 path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1)
pmid:26195256 path(MESH:"Alzheimer Disease") increases p(HGNC:AGER)
pmid:26195256 path(MESH:"Alzheimer Disease") increases path(MESH:"Calcification, Physiologic")
pmid:26195256 path(MESH:"Alzheimer Disease") increases path(MESH:Fibrosis)
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"3R tau")
pmid:26631930 path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 259))
pmid:26631930 path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 290))
pmid:26631930 path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 321))
pmid:26631930 path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 353))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:29276758 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:21427723 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(NGlyco))
pmid:26631930 path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(OGlyco))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:17050703 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
pmid:26631930 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:MAPT, pmod(Me))
pmid:26631930 path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, frag("?"))
pmid:26631930 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, frag("26_230"))
pmid:26631930 path(MESH:"Alzheimer Disease") increases a(CHEBI:"iron(0)")
pmid:22817713 path(MESH:"Alzheimer Disease") association a(MESH:"Neuropil Threads")
pmid:29626319 path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal microautophagy")
pmid:29626319 path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:ACE))
pmid:29626319 path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SERPINF2)
pmid:29626319 path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SERPINF2))
pmid:29626319 path(MESH:"Alzheimer Disease") decreases tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid"))
pmid:25974414 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp13*"))
pmid:25974414 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp25*"))
pmid:25974414 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp368*"))
pmid:25974414 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Glu391*"))
pmid:25974414 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp421*"))
pmid:23531502 path(MESH:"Alzheimer Disease") positiveCorrelation act(a(CHEBI:acrolein))
pmid:19251756 path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"canonical glycolysis")
pmid:19251756 path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164))
pmid:19251756 path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208))
pmid:11738469 path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13"))
pmid:8985134 path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13"))
pmid:9099822 path(MESH:"Alzheimer Disease") increases act(p(HGNC:TGM2))
pmid:20096481 path(MESH:"Alzheimer Disease") association g(DBSNP:rs2651206)
pmid:21548880 path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206)
pmid:20096481 path(MESH:"Alzheimer Disease") association g(DBSNP:rs10807287)
pmid:20096481 path(MESH:"Alzheimer Disease") association g(DBSNP:rs7764257)
pmid:23666762 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MARK4)
pmid:26118667 path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"CDK5R1 p25")
pmid:21910444 path(MESH:"Alzheimer Disease") increases p(HGNC:MAPK1)
pmid:21910444 path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCB)
pmid:24401760 path(MESH:"Alzheimer Disease") increases p(HGNC:ITPKB)
pmid:29540553 path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt1)
pmid:29540553 path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt3)
pmid:21427723 path(MESH:"Alzheimer Disease") isA path(HBP:"4R tauopathy")
pmid:19732809 path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"O-GlcNAcylation")
pmid:27716675 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SUMO1)
pmid:19765634 path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs761059)
pmid:29281045 path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1)
pmid:29281045 path(MESH:"Alzheimer Disease") increases p(ECCODE:"3.1.1.89")
pmid:23157676 path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"cis p-tau")
pmid:24561250 path(MESH:"Alzheimer Disease") association complex(GO:"NLRP3 inflammasome complex")
pmid:24561250 path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:aging)
pmid:24561250 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PYCARD)
pmid:24561250 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NLRC4)
pmid:24561250 path(MESH:"Alzheimer Disease") association complex(GO:"IPAF inflammasome complex")
pmid:27314526 path(MESH:"Alzheimer Disease") association complex(GO:"inflammasome complex")
pmid:27314526 path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7)
pmid:25514383 bp(GO:"neuron cellular homeostasis") association complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN))
pmid:30046111 bp(GO:aging) decreases bp(GO:"cerebrospinal fluid circulation")
pmid:30046111 bp(GO:aging) decreases act(a(HP:"interstitial fluid"))
pmid:30046111 bp(GO:aging) increases a(CHEBI:"amyloid-beta")
pmid:29626319 bp(GO:aging) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:30046111 bp(GO:aging) decreases act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 bp(GO:aging) negativeCorrelation act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 bp(GO:aging) decreases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space"))
pmid:30046111 bp(GO:aging) association bp(GO:"immune response")
pmid:30046111 bp(GO:aging) association bp(GO:"inflammatory response")
pmid:30046111 bp(GO:aging) association bp(GO:"phospholipid metabolic process")
pmid:30046111 bp(GO:aging) association bp(GO:"extracellular matrix organization")
pmid:30046111 bp(GO:aging) association bp(GO:"cell adhesion")
pmid:30046111 bp(GO:aging) association bp(GO:"endothelial tube morphogenesis")
pmid:30046111 bp(GO:aging) decreases p(MGI:Cdk5r1)
pmid:30046111 bp(GO:aging) decreases p(MGI:Adamts3)
pmid:30046111 bp(GO:aging) decreases p(MGI:Fgfr3)
pmid:29196815 bp(GO:aging) increases path(MESH:"Alzheimer Disease")
pmid:24561250 bp(GO:aging) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29196815 bp(GO:aging) increases a(HBP:HBP00074)
pmid:25514383 bp(GO:aging) association path(MESH:Dementia)
pmid:27522251 bp(GO:aging) association p(MGI:Chrna7)
pmid:11230871 bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN))
pmid:11230871 bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN))
pmid:11230871 bp(GO:aging) causesNoChange r(HGNC:CHRNA3)
pmid:11230871 bp(GO:aging) negativeCorrelation a(HBP:"alpha-4-containing nAChR")
pmid:11230871 bp(GO:aging) negativeCorrelation a(HBP:"alpha-7-containing nAChR")
pmid:23454242 bp(GO:aging) increases p(HGNC:PPP2R2C)
pmid:23454242 bp(GO:aging) decreases p(HGNC:PPP2R2B)
pmid:28083634 bp(GO:aging) increases p(MGI:Otub1)
pmid:27491084 bp(GO:aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:27491084 bp(GO:aging) decreases p(FPLX:HSPA)
pmid:27491084 bp(GO:aging) increases p(FPLX:HSPB)
pmid:14556719 bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:22908190 bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:22908190 bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:14556719 bp(GO:aging) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:14556719 bp(GO:aging) increases p(HGNC:PRNP)
pmid:23746257 bp(GO:aging) decreases bp(HBP:Proteostasis)
pmid:23746257 bp(GO:aging) decreases bp(HBP:Proteostasis)
pmid:24563850 bp(GO:aging) positiveCorrelation bp(HBP:"non-enzymatic protein modification")
pmid:24563850 bp(GO:aging) association bp(GO:"protein oxidation")
pmid:30145931 bp(GO:aging) increases p(HGNC:MAPT)
pmid:30145931 bp(GO:aging) decreases p(HGNC:MAPT)
pmid:21882945 bp(GO:aging) negativeCorrelation deg(p(HGNC:MAPT))
pmid:30116051 bp(GO:aging) decreases act(p(HGNC:SIRT1))
pmid:30116051 bp(GO:aging) decreases a(CHEBI:"NAD(+)")
pmid:29024336 bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies")
pmid:29024336 bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies")
pmid:21882945 bp(GO:aging) positiveCorrelation p(HGNC:FKBP5)
pmid:29191965 bp(GO:aging) decreases bp(GO:locomotion)
pmid:28877763 bp(GO:aging) increases p(HGNC:SYK)
pmid:28877763 bp(GO:aging) increases p(HGNC:SYK)
pmid:28877763 bp(GO:aging) increases a(HBP:"Tau aggregates")
pmid:26631930 bp(GO:aging) positiveCorrelation a(HBP:"Tau aggregates")
pmid:29626319 bp(GO:aging) negativeCorrelation p(HGNC:IDE)
pmid:25681682 bp(GO:aging) negativeCorrelation p(HGNC:AGER)
pmid:29421605 bp(GO:aging) increases p(RGD:Ptpn1)
pmid:24561250 bp(GO:aging) increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:24561250 bp(GO:aging) increases p(HGNC:IL1B)
pmid:24561250 bp(GO:aging) increases p(HGNC:IL18)
pmid:30046111 bp(GO:"cerebrospinal fluid circulation") decreases a(CHEBI:"amyloid-beta")
pmid:30046111 act(a(HP:"interstitial fluid")) decreases a(CHEBI:"amyloid-beta")
pmid:30046111 a(MESH:"Lymphatic Vessels") regulates bp(MESH:Homeostasis)
pmid:30046111 a(MESH:"Lymphatic Vessels") increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes"))
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) association tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space"))
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Parenchymal Tissue"), toLoc(MESH:"Lymph Nodes"))
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(HP:"interstitial fluid"), toLoc(MESH:"Lymph Nodes"))
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Parenchymal Tissue"))
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"cerebrospinal fluid secretion")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid"))
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"fear response")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) association bp(GO:"gene expression")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Huntington Disease")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Parkinson Disease")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Alzheimer Disease")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) association bp(GO:"excitatory chemical synaptic transmission")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases bp(GO:learning)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases bp(GO:cognition)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) association bp(GO:"neuronal signal transduction")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) regulates a(CHEBI:metabolite)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) regulates bp(MESH:Glycolysis)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"response to oxidative stress")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) negativeCorrelation bp(GO:aging)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) increases act(p(MGI:Vegfc))
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) negativeCorrelation a(CHEBI:"amyloid-beta")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta")
pmid:30046111 a(MESH:"Lymphatic Vessels") decreases a(CHEBI:"amyloid-beta")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) decreases bp(GO:"macrophage migration")
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) decreases a(MESH:Macrophages)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) negativeCorrelation path(MESH:Inflammation)
pmid:30046111 act(a(MESH:"Lymphatic Vessels")) decreases a(HBP:HBP00018)
pmid:30046111 tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) association act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 a(CHEBI:verteporfin) decreases a(MESH:"Lymphatic Vessels")
pmid:30046111 a(CHEBI:verteporfin) decreases act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 a(CHEBI:verteporfin) decreases bp(MESH:"Cerebrovascular Circulation")
pmid:30046111 a(CHEBI:verteporfin) decreases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid"))
pmid:30046111 bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 bp(MESH:"Cerebrovascular Circulation") increases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space"))
pmid:30126037 bp(MESH:"Cerebrovascular Circulation") association p(MGI:Mapt, var("p.Pro301Leu"))
pmid:30126037 bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Alzheimer Disease")
pmid:30126037 bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Cognitive Dysfunction")
pmid:30046111 p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space"))
pmid:30046111 p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Intracellular Space"), toLoc(GO:"extracellular space"))
pmid:30046111 p(MGI:Aqp4) decreases a(CHEBI:"amyloid-beta")
pmid:26195256 act(p(MGI:Aqp4)) decreases a(CHEBI:"amyloid-beta")
pmid:30046111 p(MGI:Aqp4) increases bp(GO:cognition)
pmid:19126755 bp(GO:cognition) positiveCorrelation p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7)
pmid:19126755 bp(GO:cognition) association act(p(HGNC:CHRNA7))
pmid:19721446 bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7)
pmid:19126755 bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24511233 bp(GO:cognition) association path(MESH:"Alzheimer Disease")
pmid:11230871 bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24511233 bp(GO:cognition) association path(MESH:Schizophrenia)
pmid:19721446 bp(GO:cognition) association path(MESH:Schizophrenia)
pmid:24511233 bp(GO:cognition) association a(MESH:Hippocampus)
pmid:24511233 bp(GO:cognition) association a(MESH:"Cerebral Cortex")
pmid:24511233 bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic")
pmid:21482353 bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic")
pmid:24511233 bp(GO:cognition) association p(HGNC:CHRM1)
pmid:24511233 bp(GO:cognition) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")
pmid:24511233 bp(GO:cognition) association a(MESH:"Prefrontal Cortex")
pmid:26813123 bp(GO:cognition) association bp(GO:"synaptic transmission, glutamatergic")
pmid:26813123 bp(GO:cognition) association a(CHEBI:acetylcholine)
pmid:11230871 bp(GO:cognition) negativeCorrelation a(CHEBI:acetylcholine)
pmid:25514383 bp(GO:cognition) association a(HP:"cholinergic neuron")
pmid:28445721 bp(GO:cognition) association p(FPLX:CHRN)
pmid:28445721 bp(GO:cognition) association p(FPLX:CHRN)
pmid:11230871 bp(GO:cognition) association p(FPLX:CHRN)
pmid:21482353 bp(GO:cognition) positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR")
pmid:21482353 bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA5, var("?"))
pmid:21482353 bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA3, var("?"))
pmid:21482353 bp(GO:cognition) positiveCorrelation p(HGNC:CHRNB4, var("?"))
pmid:11230871 bp(GO:cognition) association complex(a(CHEBI:nicotine), p(FPLX:CHRN))
pmid:11230871 bp(GO:cognition) association a(CHEBI:neurotransmitter)
pmid:22908190 bp(GO:cognition) positiveCorrelation act(a(GO:synapse))
pmid:24027553 bp(GO:cognition) negativeCorrelation p(HBP:"Tau C3")
pmid:21882945 bp(GO:cognition) negativeCorrelation path(MESH:Tauopathies)
pmid:21882945 bp(GO:cognition) positiveCorrelation a(PUBCHEM:134222899)
pmid:21882945 bp(GO:cognition) positiveCorrelation a(CHEBI:"NMDA receptor antagonist")
pmid:19293145 bp(GO:memory) association composite(p(HGNC:MAPK1), p(HGNC:MAPK3))
pmid:24511233 bp(GO:memory) association path(MESH:"Alzheimer Disease")
pmid:24511233 bp(GO:memory) association a(MESH:Hippocampus)
pmid:24511233 bp(GO:memory) association a(MESH:Hippocampus)
pmid:19721446 bp(GO:memory) association a(MESH:Hippocampus)
pmid:24511233 bp(GO:memory) association a(MESH:"Cerebral Cortex")
pmid:24511233 bp(GO:memory) association a(MESH:"Cerebral Cortex")
pmid:24511233 bp(GO:memory) association bp(GO:"long-term synaptic potentiation")
pmid:24511233 bp(GO:memory) association a(MESH:"Prefrontal Cortex")
pmid:17009926 bp(GO:memory) association p(FPLX:CHRN)
pmid:11230871 bp(GO:memory) association p(FPLX:CHRN)
pmid:26813123 bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic")
pmid:21482353 bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 bp(GO:memory) positiveCorrelation a(CHEBI:acetylcholine)
pmid:26813123 bp(GO:memory) association a(CHEBI:acetylcholine)
pmid:26813123 bp(GO:memory) positiveCorrelation a(MESH:"Cholinergic Neurons")
pmid:26813123 bp(GO:memory) negativeCorrelation bp(HBP:Neurodegeneration)
pmid:26813123 bp(GO:memory) association bp(MESH:"Synaptic Transmission")
pmid:26813123 bp(GO:memory) association p(HGNC:SYP)
pmid:24590577 bp(GO:memory) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:24590577 bp(GO:memory) association p(HGNC:CHRM1)
pmid:19721446 bp(GO:memory) association p(HGNC:CHRNA7)
pmid:19721446 bp(GO:memory) association a(MESH:"Entorhinal Cortex")
pmid:30106381 bp(GO:memory) association p(HGNC:ADNP)
pmid:30106381 bp(GO:memory) association a(PUBCHEM:9832404)
pmid:22908190 bp(GO:memory) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:28775333 bp(GO:memory) positiveCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate")
pmid:28775333 bp(GO:memory) negativeCorrelation p(MGI:Dyrk1a)
pmid:24355211 bp(GO:memory) negativeCorrelation p(HGNC:GSK3B)
pmid:27041503 bp(GO:memory) positiveCorrelation bp(MESH:"Long-Term Potentiation")
pmid:29540553 bp(GO:memory) positiveCorrelation p(HGNC:SIRT1)
pmid:28771976 bp(GO:memory) association a(HBP:RGFP966)
pmid:21843595 bp(GO:memory) negativeCorrelation p(MGI:Sumo3)
pmid:30046111 bp(GO:"gene expression") association act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 path(MESH:"Huntington Disease") association act(a(MESH:"Lymphatic Vessels"))
pmid:26813123 path(MESH:"Huntington Disease") negativeCorrelation act(p(HGNC:CHAT))
pmid:25437566 path(MESH:"Huntington Disease") decreases p(HGNC:HSP90AB1)
pmid:25437566 path(MESH:"Huntington Disease") decreases p(HGNC:HSPA8)
pmid:25437566 path(MESH:"Huntington Disease") decreases p(HGNC:HSPA14)
pmid:25437566 path(MESH:"Huntington Disease") decreases p(HGNC:TCP1)
pmid:14556719 path(MESH:"Huntington Disease") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
pmid:14556719 path(MESH:"Huntington Disease") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
pmid:25784053 path(MESH:"Huntington Disease") positiveCorrelation p(FPLX:HSPA)
pmid:25784053 path(MESH:"Huntington Disease") negativeCorrelation p(HGNC:ATF6)
pmid:18930136 path(MESH:"Huntington Disease") positiveCorrelation a(GO:autolysosome)
pmid:29024336 path(MESH:"Huntington Disease") increases path(MESH:"Proteostasis Deficiencies")
pmid:29311797 path(MESH:"Huntington Disease") association p(HGNC:STUB1)
pmid:30046111 path(MESH:"Parkinson Disease") association act(a(MESH:"Lymphatic Vessels"))
pmid:19126755 path(MESH:"Parkinson Disease") association p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia"))
pmid:19126755 path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Tremor)
pmid:19126755 path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Hypokinesia)
pmid:19126755 path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Muscle Rigidity")
pmid:19126755 path(MESH:"Parkinson Disease") negativeCorrelation path(MESH:"Tobacco Use Disorder")
pmid:17009926 path(MESH:"Parkinson Disease") negativeCorrelation act(p(FPLX:CHRN))
pmid:17009926 path(MESH:"Parkinson Disease") negativeCorrelation p(FPLX:CHRN)
pmid:11230871 path(MESH:"Parkinson Disease") association p(FPLX:CHRN)
pmid:26813123 path(MESH:"Parkinson Disease") negativeCorrelation a(MESH:"Cholinergic Neurons")
pmid:24590577 path(MESH:"Parkinson Disease") association p(HGNC:CHRM4)
pmid:24590577 path(MESH:"Parkinson Disease") decreases act(a(MESH:"Dopaminergic Neurons"))
pmid:24762290 path(MESH:"Parkinson Disease") decreases path(MESH:Memory)
pmid:24762290 path(MESH:"Parkinson Disease") association path(MESH:Memory)
pmid:24762290 path(MESH:"Parkinson Disease") association complex(HBP:"alpha-4 beta-2 nAChR")
pmid:28901280 path(MESH:"Parkinson Disease") association p(MESH:"Receptors, Nicotinic")
pmid:22020111 path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:"protein aggregates")
pmid:29758300 path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:29758300 path(MESH:"Parkinson Disease") association p(HGNC:VPS35, var("?"))
pmid:29758300 path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:macroautophagy)
pmid:14556719 path(MESH:"Parkinson Disease") positiveCorrelation bp(GO:"neuron death")
pmid:14556719 path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"synaptic transmission, dopaminergic")
pmid:14556719 path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:14556719 path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:PRKN)
pmid:14556719 path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("?"))
pmid:14556719 path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("p.Ile93Met"))
pmid:14556719 path(MESH:"Parkinson Disease") association a(MESH:"Lewy Bodies")
pmid:14556719 path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala30Pro"))
pmid:14556719 path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala53Thr"))
pmid:22908190 path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA, pmod(Ub))
pmid:22908190 path(MESH:"Parkinson Disease") association p(HGNC:UCHL1)
pmid:18930136 path(MESH:"Parkinson Disease") positiveCorrelation a(GO:autophagosome)
pmid:28803412 path(MESH:"Parkinson Disease") association p(HGNC:SNCA)
pmid:28803412 path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:HBP00093)
pmid:27075649 path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:HBP00016)
pmid:30116051 path(MESH:"Parkinson Disease") association p(HGNC:PINK1, var("?"))
pmid:30116051 path(MESH:"Parkinson Disease") association p(HGNC:PRKN, var("?"))
pmid:30116051 path(MESH:"Parkinson Disease") association p(HGNC:LRRK2, var("?"))
pmid:29024336 path(MESH:"Parkinson Disease") increases path(MESH:"Proteostasis Deficiencies")
pmid:29311797 path(MESH:"Parkinson Disease") association p(HGNC:STUB1)
pmid:26751493 path(MESH:"Parkinson Disease") association g(DBSNP:rs2471738)
pmid:26751493 path(MESH:"Parkinson Disease") association g(DBSNP:rs242557)
pmid:26631930 path(MESH:"Parkinson Disease") increases a(CHEBI:"iron(0)")
pmid:24113872 path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:LRRK2)
pmid:30046111 bp(GO:"excitatory chemical synaptic transmission") association act(a(MESH:"Lymphatic Vessels"))
pmid:19293145 bp(GO:learning) association path(MESH:"Alzheimer Disease")
pmid:24511233 bp(GO:learning) association path(MESH:"Alzheimer Disease")
pmid:24511233 bp(GO:learning) association a(MESH:Hippocampus)
pmid:24511233 bp(GO:learning) association a(MESH:Hippocampus)
pmid:24511233 bp(GO:learning) association a(MESH:"Cerebral Cortex")
pmid:24511233 bp(GO:learning) association a(MESH:"Cerebral Cortex")
pmid:24511233 bp(GO:learning) association bp(GO:"long-term synaptic potentiation")
pmid:24511233 bp(GO:learning) association a(MESH:"Prefrontal Cortex")
pmid:17009926 bp(GO:learning) association p(FPLX:CHRN)
pmid:26813123 bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 bp(GO:learning) positiveCorrelation bp(GO:"synaptic transmission, cholinergic")
pmid:21482353 bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 bp(GO:learning) association a(CHEBI:acetylcholine)
pmid:24590577 bp(GO:learning) association p(HGNC:CHRM1)
pmid:19721446 bp(GO:learning) association p(HGNC:CHRNA7)
pmid:30106381 bp(GO:learning) association p(HGNC:ADNP)
pmid:30106381 bp(GO:learning) association a(PUBCHEM:9832404)
pmid:22908190 bp(GO:learning) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:24808823 bp(GO:learning) negativeCorrelation p(MGI:Ttbk1)
pmid:24808823 bp(GO:learning) negativeCorrelation p(MGI:Cdk5)
pmid:24808823 bp(GO:learning) positiveCorrelation surf(p(MGI:Grin2b))
pmid:24355211 bp(GO:learning) negativeCorrelation p(HGNC:GSK3B)
pmid:29540553 bp(GO:learning) positiveCorrelation p(HGNC:SIRT1)
pmid:21843595 bp(GO:learning) negativeCorrelation p(MGI:Sumo3)
pmid:30046111 bp(GO:"neuronal signal transduction") association act(a(MESH:"Lymphatic Vessels"))
pmid:24590577 bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1)
pmid:11230871 bp(GO:"response to oxidative stress") negativeCorrelation p(FPLX:CHRN)
pmid:14556719 bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(Ub), var("?"))
pmid:14556719 bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(HBP:misfolding), var("?"))
pmid:23746257 bp(GO:"response to oxidative stress") increases a(MESH:"Heat-Shock Proteins")
pmid:23746257 bp(GO:"response to oxidative stress") association bp(HBP:Proteostasis)
pmid:18930136 bp(GO:"response to oxidative stress") increases p(HGNC:SQSTM1)
pmid:24563850 bp(GO:"response to oxidative stress") decreases act(p(HGNC:KEAP1))
pmid:24563850 bp(GO:"response to oxidative stress") increases p(HGNC:NFE2L2)
pmid:24563850 bp(GO:"response to oxidative stress") increases act(p(FPLX:PRDX))
pmid:27671637 bp(GO:"response to oxidative stress") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:23528736 bp(GO:"response to oxidative stress") increases bp(GO:autophagy)
pmid:22419736 bp(GO:"response to oxidative stress") increases p(HGNC:AK1)
pmid:30126037 bp(GO:"cellular respiration") association act(a(MESH:Mitochondria))
pmid:30046111 bp(GO:"immune response") association bp(GO:aging)
pmid:27288790 bp(GO:"immune response") association m(MIRBASE:"hsa-mir-146a")
pmid:30106381 bp(GO:"immune response") association p(HGNC:ADNP)
pmid:30106381 bp(GO:"immune response") association a(PUBCHEM:9832404)
pmid:23746257 bp(GO:"immune response") association p(FPLX:HSP90)
pmid:30046111 bp(GO:"inflammatory response") association bp(GO:aging)
pmid:29179999 bp(GO:"inflammatory response") association act(p(FPLX:NFkappaB))
pmid:27522251 bp(GO:"inflammatory response") causesNoChange path(MESH:"Memory Disorders")
pmid:23746257 bp(GO:"inflammatory response") association bp(HBP:Proteostasis)
pmid:24563850 bp(GO:"inflammatory response") increases a(CHEBI:"reactive oxygen species")
pmid:8940412 bp(GO:"inflammatory response") positiveCorrelation act(p(RGD:Crh))
pmid:8940412 bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:antalarmin)
pmid:30126037 bp(GO:"inflammatory response") association bp(GO:"cellular senescence")
pmid:18494933 bp(GO:"inflammatory response") increases p(HGNC:DKK1)
pmid:16566606 bp(GO:"inflammatory response") increases a(CHEBI:peroxynitrite)
pmid:30046111 bp(GO:"phospholipid metabolic process") association bp(GO:aging)
pmid:30046111 bp(GO:"extracellular matrix organization") association bp(GO:aging)
pmid:30046111 bp(GO:"cell adhesion") association bp(GO:aging)
pmid:21214928 bp(GO:"cell adhesion") association p(HGNC:APP)
pmid:28901280 bp(GO:"cell adhesion") association a(MESH:Acetylcholine)
pmid:30106381 bp(GO:"cell adhesion") association p(HGNC:ADNP)
pmid:30106381 bp(GO:"cell adhesion") association a(PUBCHEM:9832404)
pmid:30046111 bp(GO:"endothelial tube morphogenesis") association bp(GO:aging)
pmid:27087442 p(MGI:Cdk5r1) negativeCorrelation p(MGI:Cdk5)
pmid:27087442 p(MGI:Cdk5r1) positiveCorrelation act(a(MESH:Neurons))
pmid:30046111 p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels")
pmid:30046111 p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels")
pmid:30046111 p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels")
pmid:30046111 p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels"))
pmid:30046111 p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels")
pmid:30046111 p(MGI:Vegfc) increases path(MESH:"Spatial Learning")
pmid:30046111 p(MGI:Vegfc) increases bp(GO:"stem cell proliferation")
pmid:30046111 p(MGI:Vegfc) increases bp(GO:cognition)
pmid:30046111 p(MGI:Vegfc) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes"))
pmid:30046111 p(MGI:Vegfc) causesNoChange tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes"))
pmid:30046111 p(MGI:Vegfc) causesNoChange a(CHEBI:"amyloid-beta")
pmid:30046111 p(MGI:Vegfc) causesNoChange path(HP:"Abnormal lymphatic vessel morphology")
pmid:30046111 composite(a(CHEBI:"poly(ethylene glycol dimethacrylate)"), p(MGI:Vegfc)) increases a(MESH:"Lymphatic Vessels")
pmid:30046111 p(MGI:Vegfc, var("p.Cys156Ser")) increases a(MESH:"Lymphatic Vessels")
pmid:30046111 p(MGI:Vegfc, var("p.Cys156Ser")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:Brain))
pmid:30046111 path(MESH:Inflammation) negativeCorrelation act(a(MESH:"Lymphatic Vessels"))
pmid:21329555 path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24027553 path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21329555 path(MESH:Inflammation) association bp(GO:"NIK/NF-kappaB signaling")
pmid:27288790 path(MESH:Inflammation) association p(FPLX:NFkappaB)
pmid:22040696 path(MESH:Inflammation) increases path(MESH:"Renal Insufficiency")
pmid:30106381 path(MESH:Inflammation) association p(HGNC:ADNP)
pmid:24027553 path(MESH:Inflammation) association act(p(HGNCGENEFAMILY:Caspases))
pmid:26195256 path(MESH:Inflammation) increases p(HGNC:MAPT, pmod(Ph))
pmid:30232325 p(HGNC:APP) increases act(p(HGNC:WNT3A))
pmid:30232325 p(HGNC:APP) increases act(p(HGNC:WNT5A))
pmid:30232325 p(HGNC:APP) increases bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 p(HGNC:APP) increases bp(GO:"non-canonical Wnt signaling pathway")
pmid:11230871 act(p(HGNC:APP)) association p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu"))
pmid:30232325 p(HGNC:APP) increases act(p(HGNC:DKK1))
pmid:30232325 p(HGNC:APP) increases act(p(HGNC:DKK1))
pmid:30232325 p(HGNC:APP) increases bp(HBP:HBP00061)
pmid:10656250 p(HGNC:APP, loc(GO:"endoplasmic reticulum")) association p(HGNC:BACE1, loc(GO:"endoplasmic reticulum"))
pmid:18650430 p(HGNC:APP) increases bp(GO:"regulation of cell growth")
pmid:18650430 p(HGNC:APP) increases bp(GO:"synapse assembly")
pmid:21214928 p(HGNC:APP) association bp(GO:"synapse assembly")
pmid:18650430 p(HGNC:APP) increases bp(MESH:"Neuronal Outgrowth")
pmid:21214928 p(HGNC:APP) association bp(MESH:"Neuronal Outgrowth")
pmid:18650430 p(HGNC:APP) increases bp(GO:"cell adhesion")
pmid:21214928 p(HGNC:APP) association bp(GO:"cell adhesion")
pmid:22122372 p(HGNC:APP) increases bp(GO:"cell adhesion")
pmid:18650430 p(HGNC:APP) regulates act(p(HGNC:SLC5A7))
pmid:21214928 p(HGNC:APP) increases a(CHEBI:"amyloid-beta")
pmid:22122372 p(HGNC:APP) increases a(CHEBI:"amyloid-beta")
pmid:18930136 deg(p(HGNC:APP)) association a(CHEBI:"amyloid-beta")
pmid:21214928 p(HGNC:APP) association bp(GO:"signal transduction")
pmid:21214928 p(HGNC:APP) association bp(GO:"calcium ion homeostasis")
pmid:21214928 p(HGNC:APP) association bp(GO:"protein transport")
pmid:21214928 p(HGNC:APP) regulates bp(GO:"protein transport")
pmid:21214928 p(HGNC:APP) association p(HGNC:ITGB1)
pmid:21214928 p(HGNC:APP) association bp(GO:"anterograde axonal protein transport")
pmid:22122372 p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides")
pmid:29758300 p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides")
pmid:14556719 p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides")
pmid:22122372 p(HGNC:APP) association a(HBP:HBP00078)
pmid:22122372 p(HGNC:APP) association a(HBP:HBP00079)
pmid:22122372 p(HGNC:APP) association a(MESH:"Receptors, Cell Surface")
pmid:12428809 p(HGNC:APP) association bp(GO:"axonal transport")
pmid:12428809 sec(p(HGNC:APP)) association bp(GO:"regulation of neuronal synaptic plasticity")
pmid:12428809 sec(p(HGNC:APP)) association bp(GO:"negative regulation of neuron apoptotic process")
pmid:22908190 p(HGNC:APP) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
pmid:22908190 p(HGNC:APP) positiveCorrelation bp(GO:endocytosis)
pmid:22908190 p(HGNC:APP) increases a(GO:endosome)
pmid:22908190 p(HGNC:APP) association a(GO:autophagosome)
pmid:22419736 p(HGNC:APP) positiveCorrelation p(HGNC:AK1)
pmid:26195256 p(HGNC:APP, loc(GO:"extracellular region")) negativeCorrelation p(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid"))
pmid:26631930 surf(p(HGNC:APP)) increases complex(p(HGNC:APP), p(HGNC:SLC40A1))
pmid:27094130 p(HGNC:APP) association p(HGNC:DAPK1, frag("637_1423"))
pmid:27094130 p(HGNC:APP) association p(HGNC:DAPK1, frag("848_1423"))
pmid:27094130 p(HGNC:APP) association p(HGNC:DAPK1, frag("1271_1423"))
pmid:30232325 act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 act(p(HGNC:WNT3A)) decreases a(CHEBI:"amyloid-beta")
pmid:30232325 act(p(HGNC:WNT3A)) increases a(CHEBI:"amyloid-beta")
pmid:30232325 bp(GO:"canonical Wnt signaling pathway") association p(HGNC:LRP6)
pmid:30232325 bp(GO:"canonical Wnt signaling pathway") decreases a(CHEBI:"amyloid-beta")
pmid:30232325 bp(GO:"canonical Wnt signaling pathway") negativeCorrelation bp(GO:"amyloid-beta formation")
pmid:30232325 act(p(HGNC:WNT5A)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway")
pmid:30232325 bp(GO:"Wnt signaling pathway, planar cell polarity pathway") association p(HGNC:VANGL2)
pmid:30232325 bp(GO:"Wnt signaling pathway, planar cell polarity pathway") increases a(CHEBI:"amyloid-beta")
pmid:30232325 bp(GO:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation bp(GO:"amyloid-beta formation")
pmid:30232325 p(HGNC:VANGL2) association bp(GO:"Wnt signaling pathway, planar cell polarity pathway")
pmid:30232325 p(HGNC:LRP6) association bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 composite(p(HGNC:APP), p(HGNC:LRP6)) increases bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 composite(p(HGNC:APP), p(HGNC:LRP6)) decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway")
pmid:30232325 composite(p(HGNC:APP), p(HGNC:LRP6)) decreases a(CHEBI:"amyloid-beta")
pmid:30232325 composite(p(HGNC:APP), p(HGNC:VANGL2)) decreases bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 composite(p(HGNC:APP), p(HGNC:VANGL2)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway")
pmid:30232325 composite(p(HGNC:APP), p(HGNC:VANGL2)) increases a(CHEBI:"amyloid-beta")
pmid:30232325 p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) decreases bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases bp(GO:"non-canonical Wnt signaling pathway")
pmid:30232325 p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases a(CHEBI:"amyloid-beta")
pmid:11230871 p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) association act(p(HGNC:APP))
pmid:11230871 p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases path(MESH:"Plaque, Amyloid")
pmid:11230871 p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) negativeCorrelation p(FPLX:CHRN)
pmid:30232325 bp(GO:"amyloid-beta formation") negativeCorrelation bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 bp(GO:"amyloid-beta formation") positiveCorrelation bp(GO:"Wnt signaling pathway, planar cell polarity pathway")
pmid:30232325 act(p(HGNC:DKK1)) decreases act(p(HGNC:WNT3A))
pmid:30232325 act(p(HGNC:DKK1)) decreases bp(GO:"canonical Wnt signaling pathway")
pmid:30232325 act(p(HGNC:DKK1)) increases act(p(HGNC:WNT5A))
pmid:30232325 act(p(HGNC:DKK1)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway")
pmid:30232325 p(HGNC:DKK1) increases bp(HBP:HBP00061)
pmid:30232325 p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines")
pmid:30232325 p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines")
pmid:30232325 p(HGNC:DKK1) increases a(CHEBI:"amyloid-beta")
pmid:30232325 p(HGNC:DKK1) increases bp(GO:"amyloid-beta formation")
pmid:18494933 p(HGNC:DKK1) increases act(p(HGNC:GSK3B))
pmid:18494933 p(HGNC:DKK1) increases act(p(HGNC:GSK3B), ma(kin))
pmid:18494933 p(HGNC:DKK1) decreases bp(GO:"Wnt signaling pathway")
pmid:18494933 p(HGNC:DKK1) positiveCorrelation deg(p(HGNC:CTNNB1))
pmid:30232325 composite(p(HGNC:APP), p(HGNC:DKK1)) decreases a(MESH:"Dendritic Spines")
pmid:24760868 a(MESH:"Dendritic Spines") association tloc(p(HGNC:MAPT))
pmid:24760868 a(MESH:"Dendritic Spines") association p(HGNC:MAPT)
pmid:24760868 a(MESH:"Dendritic Spines") association complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT))
pmid:27796283 a(MESH:"Dendritic Spines") positiveCorrelation bp(GO:"dendritic spine development")
pmid:27796283 a(MESH:"Dendritic Spines") negativeCorrelation act(p(HGNC:RHOA))
pmid:30232325 a(CHEBI:"fasudil hydrochloride") decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway")
pmid:30232325 a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:30232325 a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:14556719 a(CHEBI:"amyloid-beta polypeptide 40") increases a(HBP:"amyloid-beta fibrils")
pmid:26195256 a(CHEBI:"amyloid-beta polypeptide 40") association path(MESH:"Alzheimer Disease")
pmid:26195256 a(CHEBI:"amyloid-beta polypeptide 40") isA a(CHEBI:"amyloid-beta")
pmid:30232325 composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(MESH:"Dendritic Spines")
pmid:30232325 composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(CHEBI:"amyloid-beta")
pmid:29255009 p(MGI:Fkbp1b) increases path(MESH:Memory)
pmid:29255009 p(MGI:Fkbp1b) increases bp(MESH:Aging)
pmid:29255009 p(MGI:Fkbp1b) increases act(p(MGI:Eif3g))
pmid:29255009 p(MGI:Fkbp1b) increases act(p(MGI:Pla2g7))
pmid:29255009 p(MGI:Fkbp1b) increases act(p(MGI:S100b))
pmid:29255009 p(MGI:Fkbp1b) increases act(p(MGI:Snapc2))
pmid:29255009 p(MGI:Fkbp1b) increases bp(MESH:"Facilitated Diffusion")
pmid:29255009 p(MGI:Fkbp1b) increases bp(GO:"ectoderm development")
pmid:29255009 p(MGI:Fkbp1b) increases bp(GO:"regulation of actin cytoskeleton organization")
pmid:29255009 p(MGI:Fkbp1b) increases act(p(MESH:"Mitogen-Activated Protein Kinases"))
pmid:29255009 p(MGI:Fkbp1b) decreases act(p(MESH:"Membrane Transport Proteins"))
pmid:29255009 p(MGI:Fkbp1b) decreases bp(GO:"blood vessel development")
pmid:29255009 p(MGI:Fkbp1b) decreases bp(GO:"regulation of cellular component movement")
pmid:29255009 p(MGI:Fkbp1b) decreases a(GO:"cytoplasmic vesicle")
pmid:29255009 p(MGI:Fkbp1b) decreases tloc(a(CHEBI:"calcium(2+)"))
pmid:29255009 p(MGI:Fkbp1b) regulates p(MGI:Capn1)
pmid:29255009 p(MGI:Fkbp1b) regulates p(MGI:Ppp3cc)
pmid:29255009 p(MGI:Fkbp1b) decreases p(MGI:Hif1an)
pmid:29255009 p(MGI:Fkbp1b) decreases p(MGI:Nfkb1)
pmid:24762290 path(MESH:Memory) association path(MESH:"Parkinson Disease")
pmid:24762290 path(MESH:Memory) association complex(HBP:"alpha-4 beta-2 nAChR")
pmid:28901280 path(MESH:Memory) association p(MESH:"Receptors, Nicotinic")
pmid:29255009 p(HBP:"AAV-FKBP1B") increases p(MGI:Fkbp1b, loc(MESH:Hippocampus))
pmid:29255009 bp(MESH:Aging) decreases p(MGI:Map2)
pmid:29255009 bp(MESH:Aging) regulates p(MGI:Capn1)
pmid:29255009 bp(MESH:Aging) regulates p(MGI:Ppp3cc)
pmid:24511233 bp(MESH:Aging) association path(MESH:"Alzheimer Disease")
pmid:23528736 bp(MESH:Aging) increases path(MESH:"Alzheimer Disease")
pmid:25437566 bp(MESH:Aging) increases p(HGNC:TPR)
pmid:25437566 bp(MESH:Aging) increases p(HGNC:TPR)
pmid:25437566 bp(MESH:Aging) increases p(HGNC:TPR)
pmid:27491084 bp(MESH:Aging) increases p(HGNC:TPR)
pmid:25437566 bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:25437566 bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:25437566 bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:25437566 bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:27491084 bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:25784053 bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:25437566 bp(MESH:Aging) decreases p(FPLX:HSPA)
pmid:25437566 bp(MESH:Aging) decreases p(FPLX:HSPA)
pmid:27491084 bp(MESH:Aging) decreases p(FPLX:HSPA)
pmid:25784053 bp(MESH:Aging) decreases p(FPLX:HSPA)
pmid:25437566 bp(MESH:Aging) increases p(FPLX:HSPB)
pmid:25437566 bp(MESH:Aging) increases p(FPLX:HSPB)
pmid:27491084 bp(MESH:Aging) increases p(FPLX:HSPB)
pmid:25784053 bp(MESH:Aging) increases p(FPLX:HSPB)
pmid:25437566 bp(MESH:Aging) decreases p(HGNC:HSPD1)
pmid:27491084 bp(MESH:Aging) decreases p(HGNC:HSPD1)
pmid:25437566 bp(MESH:Aging) increases p(HGNC:HSPA2)
pmid:25437566 bp(MESH:Aging) increases p(HGNC:DNAJB2)
pmid:25437566 bp(MESH:Aging) decreases p(HGNC:HSPA12A)
pmid:25437566 bp(MESH:Aging) decreases p(HGNC:TOMM70)
pmid:25437566 bp(MESH:Aging) decreases p(HGNC:HSP90AB1)
pmid:25437566 bp(MESH:Aging) decreases p(HGNC:HSPA8)
pmid:25437566 bp(MESH:Aging) decreases p(HGNC:HSPA14)
pmid:25437566 bp(MESH:Aging) decreases p(HGNC:TCP1)
pmid:25784053 bp(MESH:Aging) regulates bp(HBP:Proteostasis)
pmid:25784053 bp(MESH:Aging) decreases p(FPLX:HSP90)
pmid:29311797 bp(MESH:Aging) increases p(FPLX:HSP90)
pmid:29311797 bp(MESH:Aging) decreases p(FPLX:HSP90)
pmid:29311797 bp(MESH:Aging) decreases p(FPLX:HSP90)
pmid:23528736 bp(MESH:Aging) decreases bp(GO:autophagy)
pmid:23528736 bp(MESH:Aging) decreases act(p(FPLX:Proteasome))
pmid:29311797 bp(MESH:Aging) decreases act(p(FPLX:Proteasome))
pmid:29311797 bp(MESH:Aging) decreases act(p(FPLX:Proteasome))
pmid:28420982 bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body"))
pmid:28420982 bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite))
pmid:29311797 bp(MESH:Aging) association path(MESH:"Neurodegenerative Diseases")
pmid:29311797 bp(MESH:Aging) decreases bp(GO:"protein folding")
pmid:29311797 bp(MESH:Aging) increases path(MESH:"Protein Aggregation, Pathological")
pmid:29311797 bp(MESH:Aging) decreases bp(MESH:Proteolysis)
pmid:29311797 bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy")
pmid:29311797 bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy")
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:PPID)
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:PPID)
pmid:29311797 bp(MESH:Aging) increases p(HGNC:FKBP5)
pmid:29311797 bp(MESH:Aging) increases p(HGNC:FKBP5)
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:PPP5C)
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:PPP5C)
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:AHSA1)
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:AHSA1)
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:FKBP4)
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:STIP1)
pmid:29311797 bp(MESH:Aging) decreases p(HGNC:PTGES3)
pmid:29311797 bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ph))
pmid:29311797 bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ac))
pmid:29311797 bp(MESH:Aging) increases p(FPLX:HSP90, pmod(NO))
pmid:29311797 bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ub))
pmid:29255009 p(MGI:Eif3g) increases bp(MESH:Aging)
pmid:29255009 p(MGI:Pla2g7) increases bp(MESH:Aging)
pmid:29255009 p(MGI:S100b) increases bp(MESH:Aging)
pmid:29255009 p(MGI:Snapc2) increases bp(MESH:Aging)
pmid:29255009 path(MESH:Aging) decreases bp(MESH:"Facilitated Diffusion")
pmid:29255009 path(MESH:Aging) decreases bp(GO:"ectoderm development")
pmid:29255009 path(MESH:Aging) decreases bp(GO:"regulation of actin cytoskeleton organization")
pmid:29255009 path(MESH:Aging) decreases act(p(MESH:"Mitogen-Activated Protein Kinases"))
pmid:29255009 path(MESH:Aging) increases act(p(MESH:"Membrane Transport Proteins"))
pmid:29255009 path(MESH:Aging) increases bp(GO:"blood vessel development")
pmid:29255009 path(MESH:Aging) increases bp(GO:"regulation of cellular component movement")
pmid:29255009 path(MESH:Aging) increases a(GO:"cytoplasmic vesicle")
pmid:29255009 path(MESH:Aging) increases p(MGI:Hif1an)
pmid:29255009 path(MESH:Aging) increases p(MGI:Nfkb1)
pmid:19126755 path(MESH:Aging) negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 path(MESH:Aging) negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 path(MESH:Aging) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 path(MESH:Aging) decreases p(MGI:Chrna4)
pmid:19126755 path(MESH:Aging) negativeCorrelation p(MGI:Chrna4)
pmid:19126755 path(MESH:Aging) negativeCorrelation p(MGI:Chrna7)
pmid:26195256 path(MESH:Aging) association path(MESH:"Alzheimer Disease")
pmid:26195256 path(MESH:Aging) decreases a(MESH:"Cerebrospinal Fluid")
pmid:19126755 a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(FPLX:CREB), ma(tscript))
pmid:19126755 a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases a(CHEBI:anandamide)
pmid:19126755 a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"signal release")
pmid:19126755 a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(MESH:"Neuronal Plasticity")
pmid:19126755 a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron migration")
pmid:22040696 tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) increases bp(GO:"neuron migration")
pmid:19126755 a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron differentiation")
pmid:19293145 a(CHEBI:"calcium(2+)") association act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors"))
pmid:23038257 a(CHEBI:"calcium(2+)") increases act(p(MESH:"Receptors, Nicotinic"))
pmid:17009926 tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(GO:cytosol))
pmid:26472524 tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization")
pmid:26472524 a(CHEBI:"calcium(2+)") regulates act(p(FPLX:CHRN))
pmid:26813123 a(CHEBI:"calcium(2+)") regulates p(FPLX:CHRN)
pmid:26813123 a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26813123 a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26813123 a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26813123 a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:serotonin), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26813123 a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:noradrenaline), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26813123 a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26088141 a(CHEBI:"calcium(2+)") association act(a(MESH:"Calcium Channels"))
pmid:19721446 a(CHEBI:"calcium(2+)") increases act(p(HGNC:CHRNA7))
pmid:19721446 a(CHEBI:"calcium(2+)") increases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:24027553 a(CHEBI:"calcium(2+)") increases act(p(HGNCGENEFAMILY:Calpains))
pmid:24027553 a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains))
pmid:24027553 a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains))
pmid:2123288 a(CHEBI:"calcium(2+)") increases act(p(FPLX:CALM))
pmid:2833519 a(CHEBI:"calcium(2+)") increases act(p(HGNC:S100B))
pmid:10537045 a(CHEBI:"calcium(2+)") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:TGM2))
pmid:23702978 a(CHEBI:"calcium(2+)") association p(HGNC:MAP3K7)
pmid:23702978 tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNC:NLRP3))
pmid:29255009 a(CHEBI:sirolimus) decreases bp(HBP:"PI3K-Akt signaling pathway")
pmid:29758300 a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR))
pmid:18930136 a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR))
pmid:29758300 a(CHEBI:sirolimus) increases bp(GO:cognition)
pmid:29758300 a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta")
pmid:29758300 a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta")
pmid:22908190 a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta")
pmid:29758300 a(CHEBI:sirolimus) increases bp(GO:autophagy)
pmid:22908190 a(CHEBI:sirolimus) increases bp(GO:autophagy)
pmid:22908190 a(CHEBI:sirolimus) increases bp(GO:autophagy)
pmid:18930136 a(CHEBI:sirolimus) increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:sirolimus) increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:sirolimus) increases bp(GO:autophagy)
pmid:29758300 a(CHEBI:sirolimus) increases bp(GO:macroautophagy)
pmid:29758300 a(CHEBI:sirolimus) increases bp(GO:macroautophagy)
pmid:26751493 a(CHEBI:sirolimus) increases bp(GO:macroautophagy)
pmid:29758300 a(CHEBI:sirolimus) decreases p(HGNC:MAPT)
pmid:23528736 a(CHEBI:sirolimus) increases deg(p(HGNC:MAPT))
pmid:29758300 a(CHEBI:sirolimus) increases bp(GO:"motor behavior")
pmid:22908190 a(CHEBI:sirolimus) decreases path(MESH:Tauopathies)
pmid:22908190 a(CHEBI:sirolimus) decreases path(MESH:Tauopathies)
pmid:25784053 a(CHEBI:sirolimus) decreases act(p(FPLX:mTORC1))
pmid:25784053 a(CHEBI:sirolimus) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:25784053 a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease")
pmid:18930136 a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease")
pmid:25784053 a(CHEBI:sirolimus) decreases path(MESH:"Machado-Joseph Disease")
pmid:25784053 a(CHEBI:sirolimus) decreases path(MESH:"Alzheimer Disease")
pmid:25784053 a(CHEBI:sirolimus) decreases path(MESH:"Parkinson Disease")
pmid:25784053 a(CHEBI:sirolimus) decreases path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:18930136 a(CHEBI:sirolimus) decreases path(MESH:"Bulbo-Spinal Atrophy, X-Linked")
pmid:27594586 a(CHEBI:sirolimus) decreases bp(GO:"TOR signaling")
pmid:27594586 a(CHEBI:sirolimus) increases r(HGNC:MMP9)
pmid:27594586 a(CHEBI:sirolimus) increases r(HGNC:MMP2)
pmid:30116051 a(CHEBI:sirolimus) decreases p(HGNC:SNCA)
pmid:30116051 a(CHEBI:sirolimus) decreases p(HGNC:FUS)
pmid:30116051 a(CHEBI:sirolimus) decreases p(HGNC:HTT)
pmid:24027553 a(CHEBI:sirolimus) increases bp(MESH:Autophagy)
pmid:29626319 a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(Ph))
pmid:29255009 bp(HBP:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b))
pmid:28745240 bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex"))
pmid:29255009 act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1b))) decreases bp(HBP:"PI3K-Akt signaling pathway")
pmid:29255009 act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1a))) decreases bp(HBP:"PI3K-Akt signaling pathway")
pmid:29255009 p(MGI:Fkbp1a) decreases bp(HBP:"PI3K-Akt signaling pathway")
pmid:30126037 act(p(MGI:Nfkb1)) increases bp(MESH:"Cell Survival")
pmid:30126037 act(p(MGI:Nfkb1)) increases bp(GO:"inflammatory response")
pmid:10656250 p(HGNC:BACE1) increases sec(a(HBP:"sAPP-beta"))
pmid:24590577 p(HGNC:BACE1) increases a(HBP:"sAPP-beta")
pmid:10656250 p(HGNC:BACE1) causesNoChange sec(a(HBP:"sAPP-alpha"))
pmid:10656250 p(HGNC:BACE1) causesNoChange p(HGNC:APP)
pmid:10656250 p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) association p(HGNC:APP, loc(GO:"endoplasmic reticulum"))
pmid:24590577 p(HGNC:BACE1) increases deg(p(HGNC:APP))
pmid:21718217 p(HGNC:BACE1) decreases p(HGNC:APP)
pmid:10656250 p(HGNC:BACE1) increases p(HGNC:APP, frag("672_770"))
pmid:10656250 p(HGNC:BACE1) association a(HBP:APP695)
pmid:10656250 p(HGNC:BACE1) association a(HBP:APP751)
pmid:21329555 p(HGNC:BACE1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30444369 p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")))
pmid:18650430 act(p(HGNC:BACE1), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("11_*")), p(HGNC:APP, frag("1_10"))))
pmid:21214928 p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:21214928 p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:21214928 p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:22122372 p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:21214928 p(HGNC:BACE1) increases bp(GO:"neuron death")
pmid:21214928 p(HGNC:BACE1) decreases bp(GO:"synaptic transmission, cholinergic")
pmid:21214928 p(HGNC:BACE1) decreases bp(GO:memory)
pmid:21214928 p(HGNC:BACE1) increases p(HGNC:APP, frag("672_713"))
pmid:21214928 p(HGNC:BACE1) increases p(HGNC:APP, frag("672_711"))
pmid:22122372 p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081)))
pmid:22122372 p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081)))
pmid:22122372 p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta")
pmid:18986241 act(p(HGNC:BACE1)) increases a(CHEBI:"amyloid-beta")
pmid:25331948 p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta")
pmid:29626319 p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta")
pmid:19126755 p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:24590577 p(HGNC:BACE1) increases a(HBP:C99)
pmid:21718217 p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:29758300 p(HGNC:BACE1) increases p(HGNC:APP, frag("?"))
pmid:14556719 p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides")))
pmid:26195256 act(p(HGNC:BACE1)) increases a(HBP:"amyloid-beta derived diffusible ligands")
pmid:19293145 a(HBP:"sAPP-beta") decreases act(a(CHEBI:"amyloid-beta"))
pmid:10656250 p(HGNC:BACE1, var("p.?")) causesNoChange sec(a(HBP:"sAPP-beta"))
pmid:24590577 a(HBP:"sAPP-alpha") increases bp(MESH:Neuroprotection)
pmid:10656250 p(HGNC:CTSD) causesNoChange sec(a(HBP:"sAPP-beta"))
pmid:18930136 p(HGNC:CTSD) decreases path(HBP:Neurodegeneration)
pmid:18930136 p(HGNC:CTSD) negativeCorrelation a(GO:lysosome)
pmid:18930136 p(HGNC:CTSD) negativeCorrelation a(GO:autophagosome)
pmid:24027553 act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD"))
pmid:24027553 act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT))
pmid:23528736 p(HGNC:CTSD) increases deg(p(HGNC:MAPT))
pmid:29626319 p(HGNC:CTSD) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD"), pmod(Ph))
pmid:24027553 act(p(HGNC:CTSD)) increases path(MESH:Neuroprotection)
pmid:24027553 act(p(HGNC:CTSD)) decreases path(HBP:neurotoxicity)
pmid:10656250 a(HBP:APP695) association p(HGNC:BACE1)
pmid:10656250 a(HBP:APP751) association p(HGNC:BACE1)
pmid:22791904 a(PUBCHEM:11249342) increases path(MESH:Nausea)
pmid:22791904 a(PUBCHEM:11249342) causesNoChange path(MESH:Nausea)
pmid:22791904 a(PUBCHEM:11249342) increases path(MESH:Vomiting)
pmid:22791904 a(PUBCHEM:11249342) causesNoChange path(MESH:Vomiting)
pmid:22791904 a(PUBCHEM:11249342) decreases p(HBP:"sAPP-alpha")
pmid:22791904 a(PUBCHEM:11249342) decreases p(HBP:"sAPP-beta")
pmid:22791904 a(PUBCHEM:11249342) decreases p(HGNC:MAPT)
pmid:22791904 a(PUBCHEM:11249342) decreases p(HGNC:MAPT, pmod(Ph))
pmid:22791904 a(PUBCHEM:11249342) decreases p(HGNC:C3)
pmid:22791904 a(PUBCHEM:11249342) decreases p(HGNC:CCL2)
pmid:22791904 a(PUBCHEM:11249342) decreases p(HGNC:CHI3L1)
pmid:22791904 a(PUBCHEM:11249342) causesNoChange p(HGNC:CFH)
pmid:19721446 path(MESH:Nausea) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine")
pmid:19721446 path(MESH:Vomiting) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine")
pmid:28745240 p(HBP:"sAPP-alpha") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HBP:"sAPP-alpha") increases bp(GO:neurogenesis)
pmid:25652642 p(HBP:"sAPP-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex"))
pmid:24760868 act(p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph))
pmid:19293145 p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles")
pmid:14556719 p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles")
pmid:14556719 deg(p(HGNC:MAPT)) increases a(MESH:"Neurofibrillary Tangles")
pmid:27574109 p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles")
pmid:26813123 act(p(HGNC:MAPT)) association act(p(HGNC:CHRM1))
pmid:24590577 p(HGNC:MAPT) regulates bp(GO:"microtubule anchoring")
pmid:24590577 p(HGNC:MAPT) regulates bp(GO:"axonal transport")
pmid:12428809 p(HGNC:MAPT) association bp(GO:"axonal transport")
pmid:12428809 p(HGNC:MAPT) increases bp(GO:"axonal transport")
pmid:21734277 tloc(p(HGNC:MAPT)) causesNoChange bp(GO:"axonal transport")
pmid:28420982 p(HGNC:MAPT) regulates bp(GO:"axonal transport")
pmid:26631930 p(HGNC:MAPT) regulates bp(GO:"axonal transport")
pmid:25514383 p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:MAPT) association path(MESH:"Alzheimer Disease")
pmid:14556719 p(HGNC:MAPT) association path(MESH:"Alzheimer Disease")
pmid:24027553 p(HGNC:MAPT) association path(MESH:"Alzheimer Disease")
pmid:24027553 p(HGNC:MAPT) association path(MESH:"Alzheimer Disease")
pmid:27574109 p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27574109 p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30126037 p(HGNC:MAPT) association path(MESH:"Alzheimer Disease")
pmid:28420982 p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28420982 p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29238289 p(HGNC:MAPT) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:26837465 p(HGNC:MAPT) decreases act(p(HGNC:ESR1), ma(tscript))
pmid:10391244 act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:19277525 p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:12428809 p(HGNC:MAPT) increases bp(GO:"microtubule cytoskeleton organization")
pmid:12428809 p(HGNC:MAPT) decreases bp(GO:"microtubule depolymerization")
pmid:12428809 p(HGNC:MAPT) increases bp(GO:"axon development")
pmid:25378699 deg(p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT, pmod(Ub))
pmid:24905733 act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ub))
pmid:29758300 p(HGNC:MAPT) increases complex(a(GO:cytoskeleton), a(GO:microtubule))
pmid:29758300 p(HGNC:MAPT) increases bp(GO:"anterograde axonal protein transport")
pmid:27373205 p(HGNC:MAPT) causesNoChange bp(GO:"anterograde axonal protein transport")
pmid:29758300 p(HGNC:MAPT) increases bp(GO:"retrograde axonal protein transport")
pmid:27373205 p(HGNC:MAPT) causesNoChange bp(GO:"retrograde axonal protein transport")
pmid:29758300 p(HGNC:MAPT) association path(MESH:Tauopathies)
pmid:29758300 p(HGNC:MAPT) association path(MESH:"Frontotemporal Dementia")
pmid:28420982 p(HGNC:MAPT) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:29758300 p(HGNC:MAPT) association path(MESH:"Niemann-Pick Diseases")
pmid:29758300 p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive")
pmid:30126037 p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive")
pmid:29758300 p(HGNC:MAPT) association p(HGNC:NBR1)
pmid:29758300 p(HGNC:MAPT) positiveCorrelation p(HGNC:TREM2)
pmid:14556719 p(HGNC:MAPT) association a(GO:microtubule)
pmid:25374103 p(HGNC:MAPT) regulates act(a(GO:microtubule))
pmid:28420982 p(HGNC:MAPT) increases a(GO:microtubule)
pmid:26631930 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) negativeCorrelation a(GO:microtubule)
pmid:29626319 p(HGNC:MAPT) increases a(GO:microtubule)
pmid:22908190 p(HGNC:MAPT) association a(HBP:"paired helical filaments")
pmid:22908190 p(HGNC:MAPT) association a(HBP:"paired helical filaments")
pmid:22908190 p(HGNC:MAPT) association a(GO:"Lewy body")
pmid:22908190 p(HGNC:MAPT) association a(GO:"Pick body")
pmid:27574109 p(HGNC:MAPT) association a(GO:"Pick body")
pmid:22908190 p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:26751493 p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:22908190 deg(p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?"))
pmid:30145931 p(HGNC:MAPT) increases p(HGNC:SQSTM1)
pmid:30145931 p(HGNC:MAPT, loc(MESH:Dendrites)) decreases a(MESH:"Dendritic Spines")
pmid:24760868 tloc(p(HGNC:MAPT)) association a(MESH:"Dendritic Spines")
pmid:24760868 p(HGNC:MAPT) association a(MESH:"Dendritic Spines")
pmid:30116051 p(HGNC:MAPT) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:23528736 deg(p(HGNC:MAPT)) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:29215007 p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly")
pmid:29215007 p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly")
pmid:24027553 p(HGNC:MAPT) increases path(MESH:"Nerve Degeneration")
pmid:24027553 deg(p(HGNC:MAPT)) association bp(GO:autophagy)
pmid:26751493 p(HGNC:MAPT) decreases bp(GO:autophagy)
pmid:27574109 p(HGNC:MAPT) association a(HBP:pretangles)
pmid:27574109 p(HGNC:MAPT) association a(HBP:"Braak_Stage I")
pmid:27574109 p(HGNC:MAPT) association a(HBP:"Braak_Stage II")
pmid:27574109 p(HGNC:MAPT) association a(HBP:"Corticobasal Degeneration")
pmid:27574109 p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration")
pmid:27574109 p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration")
pmid:27574109 p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:27574109 p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:29590627 p(HGNC:MAPT) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:26195256 p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid"))
pmid:26195256 p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles"))
pmid:26631930 p(HGNC:MAPT) positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines"))
pmid:26631930 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) positiveCorrelation p(HGNC:MAPT)
pmid:24760868 p(HGNC:MAPT, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:24760868 tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:24760868 p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:24760868 tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) association bp(MESH:"Neuronal Plasticity")
pmid:24760868 p(HGNC:MAPT) regulates bp(MESH:"Neuronal Plasticity")
pmid:24760868 p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:17187063 p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:24760868 p(HGNC:MAPT) increases complex(complex(GO:"actin filament bundle"), p(HGNC:MAPT))
pmid:24760868 p(HGNC:MAPT) association complex(GO:"filamentous actin")
pmid:17187063 p(HGNC:MAPT) directlyIncreases complex(GO:"filamentous actin")
pmid:28528849 p(HGNC:MAPT) causesNoChange a(GO:synapse)
pmid:26631930 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) decreases act(a(GO:synapse))
pmid:26631930 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) decreases act(a(GO:synapse))
pmid:26631930 p(HGNC:MAPT) negativeCorrelation act(a(GO:synapse))
pmid:29988016 p(HGNC:MAPT) increases a(HBP:"Tau aggregates")
pmid:28420982 sec(p(HGNC:MAPT)) association a(HBP:"Tau aggregates")
pmid:27373205 p(HGNC:MAPT) increases a(HBP:"Tau aggregates")
pmid:21882945 p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:29191965 p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:21882945 deg(p(HGNC:MAPT)) negativeCorrelation bp(GO:aging)
pmid:21882945 p(HGNC:MAPT) increases path(HBP:neurotoxicity)
pmid:21882945 deg(p(HGNC:MAPT)) negativeCorrelation p(HGNC:AKT1)
pmid:30126037 p(HGNC:MAPT) association path(MESH:"Brain Injuries, Traumatic")
pmid:28408124 p(HGNC:MAPT) association a(HBP:"Tau antibody, Tau46")
pmid:29191965 p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBA1A))
pmid:29191965 p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBB))
pmid:29191965 p(HGNC:MAPT) directlyIncreases complex(p(HGNC:KLC3), p(HGNC:MAPT))
pmid:29191965 p(HGNC:MAPT) association a(GO:"cell body")
pmid:25374103 p(HGNC:MAPT) negativeCorrelation bp(GO:"anterograde axonal transport")
pmid:26631930 p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport")
pmid:28420982 p(HGNC:MAPT) regulates bp(GO:"generation of neurons")
pmid:28420982 p(HGNC:MAPT) increases bp(HP:Neurodegeneration)
pmid:28420982 p(HGNC:MAPT) increases bp(GO:"cell death")
pmid:28420982 p(HGNC:MAPT) association bp(GO:behavior)
pmid:28420982 p(HGNC:MAPT) decreases bp(GO:"synaptic signaling")
pmid:28420982 p(HGNC:MAPT) association bp(GO:"intracellular signal transduction")
pmid:28420982 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) association bp(MESH:Aging)
pmid:28420982 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) association bp(MESH:Aging)
pmid:28420982 sec(p(HGNC:MAPT)) association a(MESH:Exosomes)
pmid:29238289 p(HGNC:MAPT) association act(a(MESH:Exosomes))
pmid:28420982 sec(p(HGNC:MAPT)) association a(GO:microvesicle)
pmid:28420982 p(HGNC:MAPT) increases a(CHEBI:"calcium(2+)")
pmid:28420982 p(HGNC:MAPT) increases bp(GO:"neuron death")
pmid:26751493 p(HGNC:MAPT) decreases act(p(HGNC:HDAC6))
pmid:28760828 p(HGNC:MAPT) positiveCorrelation p(HGNC:HDAC6)
pmid:26751493 p(HGNC:MAPT) positiveCorrelation bp(GO:"clathrin-dependent endocytosis")
pmid:27373205 p(HGNC:MAPT) increases a(HBP:"Tau oligomers")
pmid:26631930 p(HGNC:MAPT) directlyIncreases complex(p(HGNC:FYN), p(HGNC:MAPT))
pmid:18680553 p(HGNC:MAPT) increases complex(p(HGNC:FYN), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT) directlyIncreases p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:16566606 act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
pmid:16566606 act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:16566606 act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
pmid:26631930 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) association path(HBP:Neurodegeneration)
pmid:26631930 act(p(HGNC:MAPT)) decreases path(HBP:Neurodegeneration)
pmid:26631930 p(HGNC:MAPT) association act(a(MESH:Dyneins))
pmid:26631930 p(HGNC:MAPT) association act(a(MESH:Kinesin))
pmid:26631930 p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins))
pmid:22817713 p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins))
pmid:26631930 p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin))
pmid:22817713 p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin))
pmid:26631930 p(HGNC:MAPT) decreases bp(GO:"retrograde axonal transport")
pmid:26631930 p(HGNC:MAPT) increases act(p(HGNC:GSK3B))
pmid:26631930 p(HGNC:MAPT) increases act(p(HGNC:PPP1R8))
pmid:26631930 p(HGNC:MAPT) directlyIncreases complex(p(HGNC:DCTN1), p(HGNC:MAPT))
pmid:8391280 p(HGNC:MAPT) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT) increases a(MESH:Neurites)
pmid:26631930 p(HGNC:MAPT) association bp(GO:"regulation of synaptic plasticity")
pmid:26631930 p(HGNC:MAPT) increases path(HBP:Excitotoxicity)
pmid:26631930 p(HGNC:MAPT) regulates act(a(MESH:Neurons))
pmid:26631930 p(HGNC:MAPT) increases a(MESH:Neurons)
pmid:26631930 p(HGNC:MAPT) increases act(a(MESH:Neurons))
pmid:29238289 p(HGNC:MAPT, loc(GO:"extracellular region")) increases act(a(MESH:Neurons))
pmid:29238289 p(HGNC:MAPT, loc(GO:"extracellular region")) decreases a(MESH:Neurons)
pmid:29238289 p(HGNC:MAPT) increases act(a(MESH:Neurons))
pmid:26631930 p(HGNC:MAPT) association bp(GO:neurogenesis)
pmid:26631930 p(HGNC:MAPT) increases bp(GO:neurogenesis)
pmid:26631930 p(HGNC:MAPT) decreases a(CHEBI:"iron(0)")
pmid:26631930 p(HGNC:MAPT) decreases a(CHEBI:"iron(0)")
pmid:26631930 p(HGNC:MAPT) increases bp(GO:locomotion)
pmid:26631930 p(HGNC:MAPT) increases tloc(p(HGNC:APP), fromLoc(GO:cytoplasm), toLoc(GO:"cell surface"))
pmid:26631930 p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression")
pmid:26631930 p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression")
pmid:26631930 p(HGNC:MAPT) directlyIncreases complex(a(MESH:Actins), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT) increases act(a(MESH:Brain))
pmid:26631930 p(HGNC:MAPT) negativeCorrelation path(MESH:Dementia)
pmid:26631930 p(HGNC:MAPT) increases bp(GO:"iron ion transport")
pmid:26631930 p(HGNC:MAPT) increases bp(GO:"DNA protection")
pmid:26631930 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) regulates act(a(CHEBI:"amyloid-beta"))
pmid:26631930 p(HGNC:MAPT) increases act(a(CHEBI:"amyloid-beta"))
pmid:26631930 tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines"))
pmid:26631930 p(HGNC:MAPT) increases complex(p(HGNC:DLG4), p(HGNC:FYN))
pmid:22817713 p(HGNC:MAPT) association bp(GO:"regulation of microtubule cytoskeleton organization")
pmid:29626319 p(HGNC:MAPT) decreases p(HGNC:PSMD7)
pmid:29238289 p(HGNC:MAPT) association act(a(MESH:Microtubules))
pmid:29238289 p(HGNC:MAPT, loc(GO:"extracellular region")) decreases path(MESH:Memory)
pmid:29238289 p(HGNC:MAPT, loc(GO:"extracellular region")) decreases bp(MESH:"Long-Term Potentiation")
pmid:29238289 p(HGNC:MAPT) association a(MESH:"Transport Vesicles")
pmid:29238289 p(HGNC:MAPT) association p(HGNC:RAB7A)
pmid:29238289 p(HGNC:MAPT) association p(HGNC:RAB1A)
pmid:29238289 p(HGNC:MAPT) decreases p(HBP:"Tau aggregates")
pmid:1918161 p(HGNC:MAPT) directlyIncreases complex(GO:microtubule)
pmid:6543144 p(HGNC:MAPT) association complex(GO:microtubule)
pmid:10464280 p(HGNC:MAPT) association complex(GO:microtubule)
pmid:1918161 p(HGNC:MAPT) positiveCorrelation complex(GO:axon)
pmid:1918161 p(HGNC:MAPT) positiveCorrelation complex(GO:"neuron projection")
pmid:6543144 p(HGNC:MAPT) association complex(GO:neurofilament)
pmid:2446784 p(HGNC:MAPT) association complex(GO:"polysomal ribosome")
pmid:11812770 p(HGNC:MAPT) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT))
pmid:18680553 p(HGNC:MAPT) association p(HGNC:FYN)
pmid:18680553 p(HGNC:MAPT) association bp(GO:myelination)
pmid:18467332 p(HGNC:MAPT) association p(HGNC:SRC, frag("84_145"))
pmid:18467332 p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:SRC))
pmid:18467332 p(HGNC:MAPT) association p(HGNC:PLCG1, frag("790_851"))
pmid:18467332 p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1))
pmid:18467332 p(HGNC:MAPT) association p(HGNC:GRB2, frag("1_57"))
pmid:18467332 p(HGNC:MAPT) association complex(p(HGNC:GRB2), p(HGNC:MAPT))
pmid:18467332 p(HGNC:MAPT) association p(HGNC:PIK3R1, frag("3_79"))
pmid:18467332 p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1))
pmid:10464280 p(HGNC:MAPT) increases complex(complex(GO:microtubule), p(HGNC:MAPT))
pmid:17954934 p(HGNC:MAPT) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1))
pmid:17954934 p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1)
pmid:8391280 p(HGNC:MAPT) increases act(p(INTERPRO:"Dynein associated protein"))
pmid:20071522 p(HGNC:MAPT) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT))
pmid:21367866 deg(p(HGNC:MAPT)) negativeCorrelation act(p(FPLX:HSP90))
pmid:2123288 p(HGNC:MAPT) isA complex(p(FPLX:CALM), p(HGNC:MAPT))
pmid:2123288 act(p(HGNC:MAPT)) negativeCorrelation complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT))
pmid:2123288 act(p(HGNC:MAPT)) increases bp(GO:"microtubule polymerization")
pmid:19459590 act(p(HGNC:MAPT)) positiveCorrelation bp(GO:"microtubule polymerization")
pmid:2833519 p(HGNC:MAPT) association p(HGNC:S100B)
pmid:2833519 p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:S100B))
pmid:12551948 p(HGNC:MAPT) association p(HGNC:YWHAZ)
pmid:12551948 p(HGNC:MAPT) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ))
pmid:21339331 p(HGNC:MAPT) association p(HGNC:ANXA2)
pmid:21339331 p(HGNC:MAPT) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT))
pmid:21131359 p(HGNC:MAPT) association a(CHEBI:"double-stranded DNA")
pmid:21131359 p(HGNC:MAPT) isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT))
pmid:21131359 p(HGNC:MAPT) negativeCorrelation bp(MESH:"Hot Temperature")
pmid:16566606 act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197))
pmid:24869773 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me2, Lys, 311))
pmid:24869773 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 259))
pmid:24869773 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 290))
pmid:22033876 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 290))
pmid:24869773 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 353))
pmid:24869773 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 24))
pmid:24869773 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 44))
pmid:24869773 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 67))
pmid:24869773 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 190))
pmid:22033876 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 163))
pmid:22033876 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 174))
pmid:22033876 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 180))
pmid:22033876 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 254))
pmid:22033876 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Ub, Lys, 254))
pmid:22033876 p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 267))
pmid:19251756 p(HGNC:MAPT) association p(INTERPRO:"Triosephosphate isomerase", pmod(NO))
pmid:19251756 p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO)))
pmid:10537045 p(HGNC:MAPT) positiveCorrelation p(HGNC:TGM2)
pmid:10537045 p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2))
pmid:24853415 p(HGNC:MAPT) positiveCorrelation p(HGNC:DAPK1)
pmid:24853415 p(HGNC:MAPT) positiveCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71))
pmid:22926167 p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71))
pmid:19459590 act(p(HGNC:MAPT)) negativeCorrelation p(HBP:"Tau epitope, AT8")
pmid:25031639 deg(p(HGNC:MAPT)) positiveCorrelation a(HBP:"Tau epitope, PHF1")
pmid:29540553 p(HGNC:MAPT) negativeCorrelation p(MGI:Sirt3)
pmid:22926167 p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 16))
pmid:22926167 p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 65))
pmid:22926167 p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ac, Lys, 46))
pmid:21214928 p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle")
pmid:28420982 p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle")
pmid:22122372 p(HGNC:MAPT, pmod(Ph)) association bp(GO:"neurofibrillary tangle assembly")
pmid:19293145 p(HGNC:MAPT, pmod(Ph)) association p(HGNC:FYN)
pmid:24653673 p(HGNC:MAPT, pmod(Ph)) association p(FPLX:PPP2, pmod(Me, Tyr, 307))
pmid:24653673 p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT))
pmid:24653673 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:MAPT, pmod(Ph)) increases path(MESH:"Alzheimer Disease")
pmid:8282104 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29191965 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29191965 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29311797 p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Alzheimer Disease")
pmid:26458742 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27373205 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation a(CHEBI:homocysteine)
pmid:24653673 p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(FPLX:PPP2, pmod(Me))
pmid:29758300 p(HGNC:MAPT, pmod(Ph)) decreases act(complex(GO:"proteasome complex"))
pmid:29758300 p(HGNC:MAPT, pmod(Ph)) association complex(GO:"proteasome complex")
pmid:29758300 p(HGNC:MAPT, pmod(Ph)) association bp(GO:autophagy)
pmid:29758300 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MTOR)
pmid:29758300 deg(p(HGNC:MAPT, pmod(Ph))) decreases bp(GO:"neuron death")
pmid:29758300 deg(p(HGNC:MAPT, pmod(Ph))) decreases path(HBP:neuroinflammation)
pmid:29758300 deg(p(HGNC:MAPT, pmod(Ph))) increases bp(GO:cognition)
pmid:29758300 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:TREM2)
pmid:29758300 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr"))
pmid:24027553 p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Neurofibrillary Tangles")
pmid:24027553 p(HGNC:MAPT, pmod(Ph)) decreases act(a(CHEBI:Thrombin))
pmid:17403556 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(HBP:Neurodegeneration)
pmid:24760868 p(HGNC:MAPT, pmod(Ph)) association act(p(HGNC:MAPT))
pmid:21734277 p(HGNC:MAPT, pmod(Ph)) association p(HBP:"AT8 tau", pmod(Ph))
pmid:21882945 p(HGNC:MAPT, pmod(Ph)) regulates complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:21882945 p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:21882945 deg(p(HGNC:MAPT, pmod(Ph))) association p(HGNC:BAG2)
pmid:22419736 p(HGNC:MAPT, pmod(Ph)) negativeCorrelation act(p(ECCODE:"2.7.11.31"))
pmid:22419736 p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Retinal Degeneration")
pmid:29191965 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates")
pmid:22817713 p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates")
pmid:28420982 p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau oligomers")
pmid:28420982 p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau oligomers")
pmid:26195256 p(HGNC:MAPT, pmod(Ph)) decreases act(p(MESH:Calpain))
pmid:27373205 p(HGNC:MAPT, pmod(Ph)) increases composite(a(HBP:"Tau antibody, TNT1"), a(HBP:TOC1), p(HGNC:MAPT, pmod(Ph), var("p.S422E")), loc(MESH:Brain))
pmid:26631930 p(HGNC:MAPT, pmod(Ph)) decreases complex(a(MESH:Actins), p(HGNC:MAPT))
pmid:27260836 p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"neurofibrillary tangle")
pmid:27260836 p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"neurofibrillary tangle")
pmid:27260836 p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM)
pmid:27260836 p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM)
pmid:27260836 p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Pick body")
pmid:27260836 p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Cajal body")
pmid:18467332 p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:SRC))
pmid:18467332 p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PLCG1))
pmid:18467332 p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:GRB2), p(HGNC:MAPT))
pmid:18467332 p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PIK3R1))
pmid:10464280 p(HGNC:MAPT, pmod(Ph)) negativeCorrelation rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT)))
pmid:19363271 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(FPLX:HSP90)
pmid:14963027 p(HGNC:MAPT, pmod(Ph)) association p(HGNC:HSPB1)
pmid:14963027 p(HGNC:MAPT, pmod(Ph)) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))
pmid:14963027 act(p(HGNC:MAPT, pmod(Ph))) increases bp(GO:"neuron apoptotic process")
pmid:14612456 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ub))
pmid:14612456 p(HGNC:MAPT, pmod(Ph)) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2))
pmid:17954934 p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:BAG1)
pmid:23943618 p(HGNC:MAPT, pmod(Ph)) negativeCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT))
pmid:16630055 p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation"))
pmid:25378699 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340))
pmid:29062069 p(HGNC:MAPT, pmod(Ph)) negativeCorrelation act(p(HGNC:PPP2CA))
pmid:19401603 p(HGNC:MAPT, pmod(Ph)) positiveCorrelation complex(GO:"tubulin complex")
pmid:21718217 p(HGNC:CCL2) increases bp(GO:"microglial cell activation")
pmid:25681350 a(PUBCHEM:14235) increases r(MGI:"chitinase-like 1")
pmid:25681350 a(PUBCHEM:14235) increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")
pmid:25681350 r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 1 alpha")
pmid:25681350 r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 6")
pmid:25681350 r(MGI:"interleukin 1 alpha") positiveCorrelation r(MGI:"chitinase-like 1")
pmid:25681350 r(MGI:"interleukin 6") positiveCorrelation r(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 1 alpha")
pmid:25681350 p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 6")
pmid:25681350 p(MGI:"interleukin 1 alpha") increases complex(GO:"NF-kappaB complex")
pmid:25681350 p(MGI:"interleukin 1 alpha") increases p(MGI:"signal transducer and activator of transcription 3")
pmid:25681350 p(MGI:"interleukin 1 alpha") increases act(p(MGI:"signal transducer and activator of transcription 3"))
pmid:25681350 p(MGI:"interleukin 1 alpha") increases r(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"interleukin 1 alpha") increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")
pmid:25681350 p(MGI:"interleukin 1 alpha") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"))
pmid:25681350 p(MGI:"interleukin 1 alpha") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")))
pmid:25681350 p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:25681350 act(p(MGI:"interleukin 1 alpha")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:25681350 p(MGI:"interleukin 1 alpha") increases path(MESH:Glioblastoma)
pmid:25681350 p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:25681350 p(MGI:"interleukin 1 alpha") regulates p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"interleukin 1 alpha") increases p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")
pmid:28745240 complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission")
pmid:28745240 complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death")
pmid:28745240 complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death")
pmid:28745240 complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death")
pmid:28745240 complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity")
pmid:28745240 complex(GO:"NF-kappaB complex") regulates bp(GO:cognition)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates bp(GO:behavior)
pmid:28745240 complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory")
pmid:28745240 complex(GO:"NF-kappaB complex") increases bp(GO:memory)
pmid:28745240 complex(GO:"NF-kappaB complex") increases bp(GO:learning)
pmid:28745240 complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA))
pmid:28745240 complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1)
pmid:28745240 complex(GO:"NF-kappaB complex") decreases sec(a(PUBCHEM:16057918))
pmid:28745240 complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process")
pmid:28745240 complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process")
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2A1)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) decreases act(a(MESH:"Amyloid beta-Peptides"))
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2)
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:SOD2))
pmid:28745240 act(complex(GO:"NF-kappaB complex")) decreases p(MESH:Proteins, pmod(HBP:nitration))
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates a(MESH:"Neural Stem Cells")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) negativeCorrelation a(MESH:"Cerebral Cortex")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(GO:"stem cell division")
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
pmid:25652642 complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(GO:"astrocyte development")
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:LIF)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(GO:"dendritic spine organization")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases a(GO:axon)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases bp(GO:"axon guidance")
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:ITGB1)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:NCAM1)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:SLITRK1)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:GFRA1)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:TIAM1)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Dendritic Cells")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases a(GO:"dendritic branch")
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES1)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES5)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:MAP1B)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:C3)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:CFB)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:CR2)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:C4A)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:C4BPA)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:IL1B)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B)
pmid:25652642 complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B)
pmid:28745240 complex(GO:"NF-kappaB complex") increases act(p(HGNC:IL1A))
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28745240 complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1)))
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:TNF)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:TNF)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:TNF)
pmid:25652642 complex(GO:"NF-kappaB complex") increases p(HGNC:TNF)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases sec(a(CHEBI:"amyloid-beta"))
pmid:28745240 act(complex(GO:"NF-kappaB complex")) increases a(CHEBI:"amyloid-beta")
pmid:28745240 complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta")
pmid:28745240 complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) regulates a(CHEBI:"amyloid-beta")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1)
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1)
pmid:25652642 act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:BACE1)
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases p(HGNC:BACE1)
pmid:21958873 complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1)
pmid:25331948 complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates bp(HBP:"APP processing")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases bp(HBP:"APP processing")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(HBP:"APP processing")
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HBP:C99)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates act(complex(GO:"gamma-secretase complex"))
pmid:28745240 complex(GO:"NF-kappaB complex") increases act(complex(GO:"gamma-secretase complex"))
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:PSEN1)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:APP)
pmid:28745240 complex(GO:"NF-kappaB complex") regulates p(HGNC:APP)
pmid:25652642 act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:APP)
pmid:28745240 act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"calcium ion homeostasis")
pmid:28745240 complex(GO:"NF-kappaB complex") increases p(HGNC:CXCL8)
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases bp(GO:"inflammatory response")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Free Radicals")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:25652642 complex(GO:"NF-kappaB complex") association path(MESH:"Plaque, Amyloid")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases p(HBP:"sAPP-beta")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(HBP:"sAPP-beta")
pmid:25652642 complex(GO:"NF-kappaB complex") association act(p(HGNC:APOE))
pmid:25652642 complex(GO:"NF-kappaB complex") increases bp(MESH:Neuroprotection)
pmid:25652642 complex(GO:"NF-kappaB complex") regulates bp(MESH:Neuroprotection)
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases a(CHEBI:peroxynitrite)
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"membrane depolarization")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) decreases a(MESH:"Cholinergic Neurons")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia))
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines))
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)"))
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species"))
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species"))
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2))
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2))
pmid:25652642 act(complex(GO:"NF-kappaB complex")) increases path(HBP:neurotoxicity)
pmid:25652642 complex(GO:"NF-kappaB complex") regulates m(HGNC:"MIR9-1")
pmid:25652642 complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR34A)
pmid:25652642 complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR125B1)
pmid:25652642 complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR146A)
pmid:25652642 complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR155)
pmid:25652642 complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR339)
pmid:21958873 complex(GO:"NF-kappaB complex") regulates p(HGNC:CRP)
pmid:25681350 p(MGI:"signal transducer and activator of transcription 3") association p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"signal transducer and activator of transcription 3") increases p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1")
pmid:25681350 act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"interleukin 1 alpha"))
pmid:25681350 act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"oncostatin M"))
pmid:25681350 p(MGI:"oncostatin M") increases complex(GO:"NF-kappaB complex")
pmid:25681350 p(MGI:"oncostatin M") increases p(MGI:"signal transducer and activator of transcription 3")
pmid:25681350 p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3"))
pmid:25681350 p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3"))
pmid:25681350 p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"oncostatin M") increases path(MESH:Glioblastoma)
pmid:25681350 p(MGI:"oncostatin M") regulates p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"oncostatin M") increases p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"oncostatin M") increases complex(p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:25681350 p(MGI:"oncostatin M") increases act(p(MGI:"interleukin 1 alpha"))
pmid:25681350 p(MGI:"oncostatin M") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:25681350 p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") decreases p(MGI:"chemokine (C-X-C motif) ligand 15")
pmid:25681350 p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)")
pmid:25681350 p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)")
pmid:25681350 p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)")
pmid:25681350 p(MGI:"chitinase-like 1") association p(MGI:"signal transducer and activator of transcription 3")
pmid:25681350 p(MGI:"chitinase-like 1") association p(MGI:"reticuloendotheliosis oncogene")
pmid:25681350 p(MGI:"chitinase-like 1") association p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100")
pmid:25681350 p(MGI:"chitinase-like 1") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:25681350 p(MGI:"chitinase-like 1") increases complex(a(GO:"NF-kappaB p50/p65 complex"), p(MGI:"chitinase-like 1"))
pmid:25681350 p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"interleukin 1 alpha"))
pmid:25681350 p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"oncostatin M"))
pmid:25681350 p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases r(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"interleukin 1 alpha"))
pmid:25681350 p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"oncostatin M"))
pmid:25681350 p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases r(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") regulates p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"interleukin 1 alpha"))
pmid:25681350 p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"oncostatin M"))
pmid:25681350 p(MGI:"reticuloendotheliosis oncogene") association p(MGI:"chitinase-like 1")
pmid:25681350 p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") association p(MGI:"chitinase-like 1")
pmid:25681350 p(HGNC:IL1A) increases p(HGNC:RELB)
pmid:25681350 p(HGNC:IL1A) causesNoChange r(HGNC:CHI3L1)
pmid:25681350 p(HGNC:IL1A) causesNoChange r(HGNC:RELB)
pmid:28745240 act(p(HGNC:IL1A)) increases bp(GO:"p38MAPK cascade")
pmid:23702978 p(HGNC:IL1A) increases act(p(HGNC:IL1R1))
pmid:23702978 p(HGNC:IL1A) increases bp(GO:"inflammatory response")
pmid:25681350 p(HGNC:RELB) causesNoChange p(HGNC:CHI3L1)
pmid:25681350 p(MGI:"tumor necrosis factor") increases act(complex(GO:"NF-kappaB complex"))
pmid:25681350 p(MGI:"tumor necrosis factor") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"))
pmid:25681350 p(MGI:"tumor necrosis factor") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")))
pmid:25681350 complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) regulates p(MGI:"chitinase-like 1")
pmid:25681350 complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases p(MGI:"chitinase-like 1")
pmid:25681350 complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:25681350 complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:21718217 r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25681350 p(HGNC:OSM) causesNoChange r(HGNC:CHI3L1)
pmid:25681350 p(HGNC:OSM) causesNoChange r(HGNC:RELB)
pmid:25681350 p(HGNC:RELA) causesNoChange p(HGNC:CHI3L1)
pmid:21329555 p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21329555 p(HGNC:RELA) increases r(HGNC:BACE1)
pmid:21329555 p(HGNC:RELA) increases p(HGNC:BACE1)
pmid:21329555 p(HGNC:RELA) increases p(HBP:C99)
pmid:21329555 p(HGNC:RELA) causesNoChange p(HGNC:APP)
pmid:21329555 p(HGNC:RELA) increases a(CHEBI:"amyloid-beta")
pmid:28745240 p(HGNC:RELA) increases bp(MESH:"Synaptic Transmission")
pmid:28745240 p(HGNC:RELA) increases bp(GO:"long-term synaptic potentiation")
pmid:28745240 p(HGNC:RELA) negativeCorrelation bp(GO:"apoptotic process")
pmid:27288790 act(p(HGNC:RELA)) increases bp(GO:"apoptotic process")
pmid:27288790 p(HGNC:RELA) decreases bp(GO:"neuron apoptotic process")
pmid:25681350 p(HGNC:STAT3) causesNoChange p(HGNC:CHI3L1)
pmid:28745240 p(HGNC:STAT3) increases bp(GO:"astrocyte development")
pmid:19293145 act(p(HGNC:STAT3)) association p(HGNC:JAK2)
pmid:19293145 act(p(HGNC:STAT3)) association act(a(CHEBI:nicotine))
pmid:30116051 p(HGNC:STAT3) decreases bp(GO:macroautophagy)
pmid:25681350 path(MESH:Glioblastoma) increases p(MGI:"chitinase-like 1")
pmid:25681350 path(MESH:Glioblastoma) increases p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")
pmid:25681350 composite(p(MGI:"interleukin 1 alpha"), p(MGI:"oncostatin M")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))
pmid:21329555 complex(g(HGNC:BACE1), p(FPLX:NFkappaB)) regulates r(HGNC:BACE1)
pmid:21329555 act(p(FPLX:NFkappaB), ma(tscript)) increases r(HGNC:BACE1)
pmid:29179999 act(p(FPLX:NFkappaB)) association bp(GO:"inflammatory response")
pmid:29179999 tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases bp(GO:"inflammatory response")
pmid:27288790 p(FPLX:NFkappaB) regulates bp(GO:"inflammatory response")
pmid:29179999 p(FPLX:NFkappaB) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 act(p(FPLX:NFkappaB)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29179999 act(p(FPLX:NFkappaB)) association path(HP:Neurodegeneration)
pmid:29179999 act(p(FPLX:NFkappaB)) regulates p(FPLX:"NADPH_oxidase")
pmid:29179999 act(p(FPLX:NFkappaB)) regulates p(HGNC:PTGS2)
pmid:27288790 p(FPLX:NFkappaB) regulates p(HGNC:PTGS2)
pmid:29179999 act(p(FPLX:NFkappaB)) regulates a(MESH:Interleukins)
pmid:29179999 act(p(FPLX:NFkappaB)) regulates p(FPLX:SOD)
pmid:29179999 act(p(FPLX:NFkappaB)) increases p(HGNC:BACE1)
pmid:27288790 p(FPLX:NFkappaB) association path(MESH:Inflammation)
pmid:27288790 p(FPLX:NFkappaB) association bp(GO:"negative regulation of neuron apoptotic process")
pmid:27288790 p(FPLX:NFkappaB) association bp(GO:"neuron differentiation")
pmid:27288790 p(FPLX:NFkappaB) association bp(GO:"apoptotic process")
pmid:27288790 p(FPLX:NFkappaB) association bp(MESH:"Neuronal Outgrowth")
pmid:27288790 p(FPLX:NFkappaB) association bp(GO:"regulation of synaptic plasticity")
pmid:27288790 act(p(FPLX:NFkappaB)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:27288790 act(p(FPLX:NFkappaB)) increases complex(a(MESH:DNA), p(FPLX:NFkappaB))
pmid:27288790 act(p(FPLX:NFkappaB)) increases p(HGNC:IL1B)
pmid:27288790 act(p(FPLX:NFkappaB)) increases p(HGNC:TNF)
pmid:27288790 act(p(FPLX:NFkappaB)) decreases p(HGNC:UCHL1)
pmid:27288790 p(FPLX:NFkappaB) regulates act(p(HGNC:NOS2))
pmid:27288790 act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines)
pmid:27288790 act(p(FPLX:NFkappaB)) increases a(MESH:Chemokines)
pmid:27288790 p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-1")
pmid:27288790 p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-2")
pmid:27288790 p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-146a")
pmid:27288790 p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-155")
pmid:27288790 act(p(FPLX:NFkappaB), ma(tscript)) increases m(MIRBASE:"hsa-mir-155")
pmid:30640040 p(FPLX:NFkappaB) association a(PUBCHEM:5318517)
pmid:26118667 p(FPLX:NFkappaB) increases complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB))
pmid:21329555 complex(g(HGNC:BACE1), p(HGNC:RELA)) increases r(HGNC:BACE1)
pmid:21329555 p(HGNC:NFKBIA) decreases a(CHEBI:"amyloid-beta")
pmid:29179999 p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB))
pmid:27288790 p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB))
pmid:21329555 bp(GO:"NIK/NF-kappaB signaling") association path(MESH:Inflammation)
pmid:21329555 bp(GO:"NIK/NF-kappaB signaling") association path(MESH:"Oxidative Stress")
pmid:21329555 path(MESH:"Oxidative Stress") association bp(GO:"NIK/NF-kappaB signaling")
pmid:21329555 p(HGNC:TNF) increases bp(GO:"NIK/NF-kappaB signaling")
pmid:21329555 p(HGNC:TNF) increases r(HGNC:BACE1)
pmid:21329555 p(HGNC:TNF) increases r(HGNC:BACE1)
pmid:21329555 p(HGNC:TNF) increases act(p(FPLX:NFkappaB), ma(tscript))
pmid:29179999 p(HGNC:TNF) increases act(p(FPLX:NFkappaB))
pmid:27288790 p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:27288790 p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:27288790 p(HGNC:TNF) increases act(p(FPLX:NFkappaB))
pmid:28745240 p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex"))
pmid:21958873 p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex"))
pmid:25331948 p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28745240 p(HGNC:TNF) increases path(HBP:neurotoxicity)
pmid:28745240 p(HGNC:TNF) increases bp(GO:"neuron death")
pmid:27288790 p(HGNC:TNF) increases p(FPLX:"IKK_complex", pmod(Ph))
pmid:27288790 p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph))
pmid:23178521 p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph))
pmid:23178521 p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph))
pmid:23178521 p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph))
pmid:27288790 p(HGNC:TNF) decreases p(FPLX:IKB)
pmid:27288790 p(HGNC:TNF) increases a(MESH:Cytokines)
pmid:27288790 p(HGNC:TNF) increases a(MESH:Chemokines)
pmid:27288790 p(HGNC:TNF) increases act(p(HGNC:BACE1))
pmid:21958873 p(HGNC:TNF) increases p(HGNC:BACE1)
pmid:25331948 p(HGNC:TNF) increases p(HGNC:BACE1)
pmid:25331948 p(HGNC:TNF) increases p(HGNC:BACE1)
pmid:27288790 p(HGNC:TNF) increases act(p(FPLX:ERK))
pmid:27288790 p(HGNC:TNF) increases p(HGNC:MAPT, pmod(Ph))
pmid:25652642 p(HGNC:TNF) increases p(HGNC:NGF)
pmid:25652642 p(HGNC:TNF) increases p(HGNC:BCL2)
pmid:19126755 p(HGNC:TNF) increases bp(GO:"MAPK cascade")
pmid:19293145 p(HGNC:TNF) increases act(a(CHEBI:nicotine))
pmid:19293145 p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid"))
pmid:23178521 p(HGNC:TNF) causesNoChange p(HGNC:STAT3, pmod(Ph))
pmid:23178521 p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph))
pmid:25331948 p(HGNC:TNF) increases a(MESH:"Amyloid beta-Peptides")
pmid:21329555 a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1)
pmid:21329555 a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1)
pmid:21329555 a(CHEBI:"acetylsalicylic acid") isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal")
pmid:21329555 a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases r(HGNC:BACE1)
pmid:27288790 a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:BACE1))
pmid:19126755 a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS1))
pmid:19126755 a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS2))
pmid:21329555 a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal")
pmid:27288790 a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal")
pmid:21329555 a(CHEBI:ibuprofen) decreases r(HGNC:BACE1)
pmid:27288790 a(CHEBI:ibuprofen) decreases r(HGNC:BACE1)
pmid:27288790 a(CHEBI:ibuprofen) decreases a(CHEBI:"amyloid-beta")
pmid:21329555 a(PUBCHEM:3715) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal")
pmid:21329555 a(PUBCHEM:3715) decreases r(HGNC:BACE1)
pmid:28745240 p(HGNC:SYP) increases complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP))
pmid:26813123 p(HGNC:SYP) association bp(GO:memory)
pmid:28745240 p(HGNC:NFKB1) increases bp(GO:"long-term synaptic potentiation")
pmid:28745240 p(HGNC:NFKB1) increases path(MESH:"Spatial Memory")
pmid:28745240 p(HGNC:NFKB1) increases bp(GO:learning)
pmid:28745240 p(HGNC:NFKB1) increases path(MESH:Anxiety)
pmid:27288790 act(p(HGNC:NFKB1)) increases bp(GO:"apoptotic process")
pmid:23702978 p(HGNC:NFKB1) increases p(HGNC:IL1B)
pmid:28745240 a(GO:synapse) association complex(p(HGNC:NFKB1), p(HGNC:RELA))
pmid:26813123 a(GO:synapse) negativeCorrelation path(MESH:"Cognitive Dysfunction")
pmid:25514383 a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:28445721 act(a(GO:synapse)) regulates p(FPLX:CHRN)
pmid:30106381 act(a(GO:synapse)) association p(HGNC:ADNP)
pmid:30106381 act(a(GO:synapse)) association a(PUBCHEM:9832404)
pmid:22908190 act(a(GO:synapse)) positiveCorrelation bp(GO:cognition)
pmid:22908190 act(a(GO:synapse)) decreases path(MESH:"Plaque, Amyloid")
pmid:22908190 act(a(GO:synapse)) positiveCorrelation bp(GO:endocytosis)
pmid:22908190 act(a(GO:synapse)) positiveCorrelation p(HGNC:CTSB)
pmid:26631930 act(a(GO:synapse)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:"excitatory synapse"))
pmid:26631930 act(a(GO:synapse)) negativeCorrelation p(HGNC:MAPT)
pmid:27807169 a(GO:synapse) positiveCorrelation p(RGD:Cdk5r2)
pmid:22156579 a(GO:synapse) negativeCorrelation p(HGNC:MARK4)
pmid:28745240 complex(p(HGNC:NFKB1), p(HGNC:RELA)) association a(GO:synapse)
pmid:28745240 complex(p(HGNC:NFKB1), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA))
pmid:25652642 act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) increases bp(GO:"apoptotic process")
pmid:21214928 bp(MESH:"Synaptic Transmission") association a(CHEBI:"amyloid-beta")
pmid:26813123 bp(MESH:"Synaptic Transmission") association bp(GO:memory)
pmid:14556719 bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN)
pmid:28745240 bp(GO:"long-term synaptic potentiation") decreases p(HGNC:NFKB1)
pmid:28745240 bp(GO:"long-term synaptic potentiation") decreases p(HGNC:RELA)
pmid:19126755 bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane")
pmid:24511233 bp(GO:"long-term synaptic potentiation") association bp(GO:learning)
pmid:24511233 bp(GO:"long-term synaptic potentiation") association bp(GO:memory)
pmid:21787755 bp(GO:"long-term synaptic potentiation") association a(HBP:"alpha-7-containing nAChR")
pmid:22908190 bp(GO:"long-term synaptic potentiation") negativeCorrelation act(p(HGNC:RAB5A))
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT, loc(GO:synapse))
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse))
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT)
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins, loc(GO:synapse))
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins)
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:FYN, loc(GO:synapse))
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1, loc(GO:synapse))
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1)
pmid:24760868 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4, loc(GO:synapse))
pmid:24760868 bp(GO:"long-term synaptic potentiation") association complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:24760868 bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:24760868 bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, var("p.T205A"), loc(MESH:"Dendritic Spines"))
pmid:21882945 bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:HSPB1)
pmid:28745240 p(HGNC:REL) increases bp(GO:"long-term synaptic depression")
pmid:28745240 bp(GO:"long-term synaptic depression") decreases p(HGNC:NFKB1)
pmid:28745240 bp(GO:"long-term synaptic depression") decreases p(HGNC:RELA)
pmid:22908190 bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A))
pmid:28745240 a(CHEBI:"glutamate(1-)") increases act(a(GO:"excitatory synapse"))
pmid:25652642 a(CHEBI:"glutamate(1-)") increases act(a(MESH:"Receptors, N-Methyl-D-Aspartate"))
pmid:25652642 a(CHEBI:"glutamate(1-)") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA)))
pmid:16273023 a(CHEBI:"glutamate(1-)") association path(MESH:D013850)
pmid:16273023 a(CHEBI:"glutamate(1-)") association path(MESH:D008568)
pmid:27087442 a(CHEBI:"glutamate(1-)") increases p(HBP:"CDK5R1 p25")
pmid:28745240 act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex"))
pmid:30444369 bp(GO:"neuron death") association p(HGNC:SH3GL2)
pmid:29196815 bp(GO:"neuron death") positiveCorrelation a(HBP:HBP00074)
pmid:21214928 bp(GO:"neuron death") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21))
pmid:22122372 bp(GO:"neuron death") association path(MESH:"Alzheimer Disease")
pmid:17009926 bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:17009926 bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25514383 bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28420982 bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21787755 bp(GO:"neuron death") association a(HBP:"alpha-7-containing nAChR")
pmid:29758300 bp(GO:"neuron death") association path(MESH:"Neurodegenerative Diseases")
pmid:14556719 bp(GO:"neuron death") positiveCorrelation path(MESH:"Parkinson Disease")
pmid:22908190 bp(GO:"neuron death") positiveCorrelation act(p(HGNC:RAB5A))
pmid:24027553 bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy)
pmid:21882945 bp(GO:"neuron death") positiveCorrelation path(MESH:Tauopathies)
pmid:28420982 bp(GO:"neuron death") association path(MESH:Tauopathies)
pmid:28745240 path(HBP:Excitotoxicity) increases bp(GO:"neuron death")
pmid:28745240 a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates bp(GO:"calcium ion import")
pmid:28745240 a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates act(p(HGNC:CAMK2A))
pmid:21214928 a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064)
pmid:21214928 a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065)
pmid:21214928 a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta")
pmid:22122372 a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00064)
pmid:22122372 a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00065)
pmid:22122372 a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases a(HBP:HBP00063)
pmid:25514383 a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:24653673 a(MESH:"Receptors, N-Methyl-D-Aspartate") association path(MESH:"Alzheimer Disease")
pmid:26751493 a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain")
pmid:27796283 a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1))
pmid:27796283 a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(Ph))
pmid:22833681 act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, AT8")
pmid:22833681 act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, PHF1")
pmid:22833681 act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, AT180")
pmid:22833681 act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases a(HBP:"Tau epitope, AT100")
pmid:28745240 bp(GO:"calcium ion import") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 bp(GO:"calcium ion import") increases act(p(HGNC:CAMK2A))
pmid:28745240 bp(GO:"calcium ion import") increases act(p(FPLX:PKC))
pmid:28745240 bp(GO:"calcium ion import") increases act(complex(GO:"phosphatidylinositol 3-kinase complex"))
pmid:28745240 bp(GO:"calcium ion import") increases act(p(FPLX:AKT))
pmid:26813123 bp(GO:"calcium ion import") regulates act(p(HGNC:CHAT))
pmid:28745240 act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(p(HGNC:CAMK2A)) increases act(complex(GO:"IkappaB kinase complex"))
pmid:28745240 act(p(HGNC:CAMK2A)) increases p(MESH:"I-kappa B Kinase", pmod(Ph))
pmid:22122372 p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 654))
pmid:22122372 p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 668))
pmid:22122372 p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Ser, 665))
pmid:26631930 p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:28745240 act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex"))
pmid:25652642 act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(p(FPLX:PKC)) increases act(complex(GO:"IkappaB kinase complex"))
pmid:28745240 act(p(FPLX:PKC)) increases p(MESH:"I-kappa B Kinase", pmod(Ph))
pmid:18650430 p(FPLX:PKC) increases sec(p(HGNC:APP))
pmid:24590577 act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface"))
pmid:26813123 p(FPLX:PKC) increases p(HGNC:SLC18A3, pmod(Ph))
pmid:26813123 p(FPLX:PKC) increases p(FPLX:CHRN, pmod(Ph))
pmid:24590577 act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10))
pmid:24590577 act(p(FPLX:PKC)) increases p(HGNC:BACE1)
pmid:24590577 act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B))
pmid:17493042 p(FPLX:PKC) increases p(HGNC:MAPT, pmod(Ph, Ser, 214))
pmid:28745240 act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"IkappaB kinase complex"))
pmid:28745240 act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases p(MESH:"I-kappa B Kinase", pmod(Ph))
pmid:28745240 act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(p(FPLX:AKT)) increases act(complex(GO:"IkappaB kinase complex"))
pmid:28745240 act(p(FPLX:AKT)) increases p(MESH:"I-kappa B Kinase", pmod(Ph))
pmid:27288790 act(p(FPLX:AKT)) increases p(HGNC:RELA)
pmid:19293145 act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process")
pmid:23454242 p(FPLX:AKT) regulates bp(GO:"apoptotic process")
pmid:19293145 p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway")
pmid:25514383 act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration)
DOI:10.4172/2168-975X.1000126 p(FPLX:AKT) directlyIncreases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:25331948 p(FPLX:AKT) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:29121589 p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:23454242 p(FPLX:AKT) regulates bp(GO:"cell growth")
pmid:23454242 p(FPLX:AKT) regulates bp(GO:"cell population proliferation")
pmid:29121589 p(FPLX:AKT) positiveCorrelation p(HGNC:NFE2L2)
pmid:28745240 act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(MESH:"I-kappa B Kinase", pmod(Ph)) increases act(complex(GO:"IkappaB kinase complex"))
pmid:24511233 bp(GO:behavior) association path(MESH:Schizophrenia)
pmid:24511233 bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic")
pmid:28420982 bp(GO:behavior) association p(HGNC:MAPT)
pmid:17009926 path(MESH:Anxiety) association p(FPLX:CHRN)
pmid:11230871 path(MESH:Anxiety) association p(FPLX:CHRN)
pmid:21482353 path(MESH:Anxiety) association bp(GO:"synaptic transmission, cholinergic")
pmid:28901280 path(MESH:Anxiety) association p(MESH:"Receptors, Nicotinic")
pmid:28775333 path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a)
pmid:28745240 act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1))
pmid:21214928 p(HGNC:PRKACA) decreases a(CHEBI:"amyloid-beta")
pmid:8282104 p(HGNC:PRKACA) association a(GO:microtubule)
pmid:8282104 p(HGNC:PRKACA) association a(HBP:HBP00006)
pmid:28745240 act(p(HGNC:CREB1)) increases bp(GO:"long-term memory")
pmid:28745240 bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex"))
pmid:21214928 bp(GO:"calcium ion homeostasis") association p(HGNC:APP)
pmid:19293145 bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:29758300 bp(GO:"calcium ion homeostasis") association p(HGNC:PSEN1)
pmid:28745240 bp(MESH:"Oxidative Stress") association a(CHEBI:"amyloid-beta")
pmid:28745240 bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process")
pmid:25652642 bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process")
pmid:27623715 bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process")
pmid:22020111 bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms")
pmid:22020111 bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26195256 bp(MESH:"Oxidative Stress") increases path(MESH:Aging)
pmid:21131359 bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus))
pmid:27623715 bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK))
pmid:27623715 bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)")
pmid:27623715 bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B)
pmid:27623715 bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic")
pmid:27623715 bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation")
pmid:23722080 bp(MESH:"Oxidative Stress") decreases a(GO:mitochondrion)
pmid:24355211 bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B)
pmid:8226987 bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:7667312 bp(MESH:"Oxidative Stress") increases a(HBP:"paired helical filaments")
pmid:28745240 bp(GO:"apoptotic process") negativeCorrelation p(HGNC:RELA)
pmid:27288790 bp(GO:"apoptotic process") association p(FPLX:NFkappaB)
pmid:19293145 bp(GO:"apoptotic process") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:24653673 bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:GSK3B))
pmid:24653673 bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:CDK5))
pmid:24653673 bp(GO:"apoptotic process") positiveCorrelation act(p(FPLX:ERK))
pmid:24027553 bp(GO:"apoptotic process") association p(HGNC:MAPT, frag("?", "17kD"))
pmid:24027553 bp(GO:"apoptotic process") increases act(p(HGNC:CASP6))
pmid:26304819 bp(GO:"apoptotic process") association r(HGNC:GAPDH)
pmid:23948915 bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:23948915 bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:23948915 bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:28745240 bp(GO:"JNK cascade") increases bp(GO:"apoptotic process")
pmid:28745240 bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 bp(GO:"Fas signaling pathway") increases bp(GO:"apoptotic process")
pmid:28745240 bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:BCL2L1) increases sec(a(PUBCHEM:16057918))
pmid:28745240 p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process")
pmid:30444369 p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process")
pmid:25652642 act(p(HGNC:BCL2L1)) decreases act(a(CHEBI:"amyloid-beta"))
pmid:28745240 p(HGNC:BCL2) decreases bp(GO:"apoptotic process")
pmid:30444369 p(HGNC:BCL2) decreases bp(GO:"apoptotic process")
pmid:23528736 p(HGNC:BCL2) decreases bp(GO:autophagy)
pmid:28745240 p(HGNC:BCL2A1) decreases bp(GO:"apoptotic process")
pmid:28745240 a(CHEBI:etoposide) increases bp(GO:"apoptotic process")
pmid:29196815 a(MESH:"Amyloid beta-Peptides") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22122372 a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease")
pmid:18650430 a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion")
pmid:22122372 a(MESH:"Amyloid beta-Peptides") association a(HBP:HBP00018)
pmid:11230871 a(MESH:"Amyloid beta-Peptides") negativeCorrelation p(FPLX:CHRN)
pmid:14556719 a(MESH:"Amyloid beta-Peptides") association path(MESH:"Plaque, Amyloid")
pmid:28745240 p(HGNC:SOD2) decreases bp(MESH:"Oxidative Stress")
pmid:28745240 p(HGNC:SOD2) decreases bp(GO:"apoptotic process")
pmid:25652642 act(p(HGNC:SOD2)) decreases act(a(CHEBI:"amyloid-beta"))
pmid:24563850 p(HGNC:SOD2) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen)))
pmid:28745240 a(CHEBI:peroxynitrite) increases p(MESH:Proteins, pmod(HBP:nitration))
pmid:16566606 a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration))
pmid:21210655 a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:formylation, Lys))
pmid:16816118 a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(Ph))
pmid:16816118 a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(HBP:nitration))
pmid:16816118 a(CHEBI:peroxynitrite) increases act(p(RGD:Gsk3b))
pmid:16816118 a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk14))
pmid:16816118 a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk11))
pmid:16816118 a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk13))
pmid:16816118 a(CHEBI:peroxynitrite) causesNoChange act(p(RGD:Mapk12))
pmid:16816118 a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:ERK))
pmid:16816118 a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:JNK))
pmid:16816118 a(CHEBI:peroxynitrite) increases bp(GO:"neurofibrillary tangle assembly")
pmid:16566606 a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
pmid:16566606 a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:16566606 a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197))
pmid:16566606 a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
pmid:27314526 a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change")
pmid:27314526 a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process")
pmid:28745240 composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection)
pmid:28745240 composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia)
pmid:19293145 bp(MESH:Neuroprotection) association p(HGNC:FYN)
pmid:19293145 bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling")
pmid:19293145 bp(MESH:Neuroprotection) association a(MESH:Calcineurin)
pmid:19293145 bp(MESH:Neuroprotection) association p(HGNC:JAK2)
pmid:19721446 bp(MESH:Neuroprotection) association p(HGNC:CHRNA7)
pmid:19721446 bp(MESH:Neuroprotection) association a(CHEBI:nicotine)
pmid:28745240 composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection)
pmid:28745240 composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia)
pmid:24653673 bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:GSK3B))
pmid:24653673 bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:CDK5))
pmid:24653673 bp(GO:neurogenesis) negativeCorrelation act(p(FPLX:ERK))
pmid:26631930 bp(GO:neurogenesis) association p(HGNC:MAPT)
pmid:28745240 p(HGNC:FGF2) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:EGF) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:VEGFA) increases act(complex(GO:"NF-kappaB complex"))
pmid:26304819 p(HGNC:VEGFA) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:28745240 path(MESH:"Cerebral Infarction") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 path(MESH:"Cerebral Infarction") increases bp(GO:neurogenesis)
pmid:28745240 path(MESH:"Brain Injuries, Traumatic") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 path(MESH:"Brain Injuries, Traumatic") increases bp(GO:neurogenesis)
pmid:30126037 path(MESH:"Brain Injuries, Traumatic") association p(HGNC:MAPT)
pmid:29626319 path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT)
pmid:26195256 path(MESH:"Brain Injuries, Traumatic") association p(HBP:"tau aggregates")
pmid:29626319 path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4)
pmid:29626319 path(MESH:"Brain Injuries, Traumatic") decreases act(p(HGNC:AQP4))
pmid:29626319 path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4)
pmid:29626319 path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system")
pmid:29626319 path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system")
pmid:24561250 path(MESH:"Brain Injuries, Traumatic") increases bp(GO:"cell death")
pmid:28745240 a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 a(CHEBI:"reactive oxygen species") increases bp(GO:neurogenesis)
pmid:29179999 a(CHEBI:"reactive oxygen species") increases act(p(FPLX:PKC))
pmid:29179999 a(CHEBI:"reactive oxygen species") increases act(p(FPLX:ERK))
pmid:29179999 a(CHEBI:"reactive oxygen species") increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:27288790 a(CHEBI:"reactive oxygen species") increases act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:"reactive oxygen species") regulates act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:"reactive oxygen species") increases act(p(FPLX:"IKK_complex"))
pmid:27288790 a(CHEBI:"reactive oxygen species") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 a(CHEBI:"reactive oxygen species") association bp(MESH:"Membrane Fluidity")
pmid:27288790 a(CHEBI:"reactive oxygen species") association bp(GO:"ion transport")
pmid:27288790 a(CHEBI:"reactive oxygen species") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:27288790 a(CHEBI:"reactive oxygen species") decreases bp(GO:autophagy)
pmid:24563850 a(CHEBI:"reactive oxygen species") regulates bp(GO:autophagy)
pmid:27288790 a(CHEBI:"reactive oxygen species") increases p(HGNC:NFKBIA, pmod(Ph))
pmid:24563850 a(CHEBI:"reactive oxygen species") increases bp(GO:"negative regulation of inflammatory response")
pmid:24563850 a(CHEBI:"reactive oxygen species") regulates bp(GO:"response to hypoxia")
pmid:24563850 a(CHEBI:"reactive oxygen species") regulates bp(GO:"leukocyte activation")
pmid:24563850 a(CHEBI:"reactive oxygen species") regulates bp(GO:"cell differentiation")
pmid:24563850 a(CHEBI:"reactive oxygen species") regulates bp(GO:"integrin activation")
pmid:23702978 a(CHEBI:"reactive oxygen species") increases act(p(HGNC:TRPM2))
pmid:23702978 a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly")
pmid:28745240 path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 path(MESH:Hypoxia) increases bp(GO:neurogenesis)
pmid:28745240 a(CHEBI:"sphingosine 1-phosphate") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 a(CHEBI:"sphingosine 1-phosphate") increases bp(GO:neurogenesis)
pmid:28745240 a(CHEBI:"nitric oxide") decreases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 a(CHEBI:"nitric oxide") decreases bp(GO:neurogenesis)
pmid:29559585 a(CHEBI:"nitric oxide") increases p(MGI:Gapdh, pmod(NO))
pmid:27601475 a(CHEBI:"nitric oxide") positiveCorrelation a(HBP:"8-nitro-cGMP")
pmid:23702978 a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(NO))
pmid:27314526 a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite)
pmid:27314526 a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3))
pmid:27314526 a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(Ph))
pmid:27314526 a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade")
pmid:28745240 path(HP:"Ischemic stroke") increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 path(HP:Seizures) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 a(MESH:"Cerebral Cortex") negativeCorrelation act(complex(GO:"NF-kappaB complex"))
pmid:24511233 a(MESH:"Cerebral Cortex") association bp(GO:cognition)
pmid:24511233 a(MESH:"Cerebral Cortex") association bp(GO:learning)
pmid:24511233 a(MESH:"Cerebral Cortex") association bp(GO:learning)
pmid:24511233 a(MESH:"Cerebral Cortex") association bp(GO:memory)
pmid:24511233 a(MESH:"Cerebral Cortex") association bp(GO:memory)
pmid:24590577 a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1)
pmid:26195256 a(MESH:"Cerebral Cortex") association path(MESH:"Alzheimer Disease")
pmid:28745240 p(HGNC:IL6) increases bp(GO:"astrocyte development")
pmid:28745240 p(HGNC:IL6) increases p(HGNC:STAT3)
pmid:28745240 p(HGNC:IL6) increases a(MESH:"Transcription Factor AP-1")
pmid:28745240 p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:IL6) association path(MESH:"Alzheimer Disease")
pmid:25652642 p(HGNC:IL6) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28745240 p(HGNC:IL6) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28745240 p(HGNC:IL6) increases bp(GO:"neuron death")
pmid:28745240 a(MESH:"Transcription Factor AP-1") increases bp(GO:"astrocyte development")
pmid:28745240 p(HGNC:LIF) increases bp(GO:"astrocyte development")
pmid:28745240 p(HGNC:LIF) increases p(HGNC:STAT3)
pmid:28745240 p(HGNC:LIF) increases a(MESH:"Transcription Factor AP-1")
pmid:28745240 p(HGNC:LIF) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:CNTF) increases bp(GO:"astrocyte development")
pmid:28745240 p(HGNC:CNTF) increases p(HGNC:STAT3)
pmid:28745240 p(HGNC:CNTF) increases a(MESH:"Transcription Factor AP-1")
pmid:28745240 p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:CNTF) increases bp(MESH:"Neuronal Outgrowth")
pmid:28745240 p(HGNC:CNTF) increases act(p(HGNC:LCK))
pmid:28745240 bp(MESH:"Neuronal Outgrowth") negativeCorrelation p(HGNC:RELA, pmod(Ph, Ser, 536))
pmid:27288790 bp(MESH:"Neuronal Outgrowth") association p(FPLX:NFkappaB)
pmid:21214928 bp(MESH:"Neuronal Outgrowth") association p(HGNC:APP)
pmid:23383175 act(a(GO:axon)) decreases path(MESH:Paralysis)
pmid:23383175 act(a(GO:axon)) decreases path(HP:"Limb muscle weakness")
pmid:28745240 p(HGNC:BDNF) increases bp(MESH:"Neuronal Outgrowth")
pmid:28745240 p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:BDNF) increases act(p(HGNC:SRC))
pmid:22040696 p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development")
pmid:22040696 p(HGNC:BDNF) regulates bp(GO:"central nervous system development")
pmid:22040696 p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity")
pmid:22040696 p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission")
pmid:22040696 p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic")
pmid:22040696 p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure")
pmid:22040696 p(HGNC:BDNF) association p(HGNC:CHRNA7)
pmid:22040696 p(HGNC:BDNF) increases p(HGNC:CHRNA7)
pmid:22040696 p(HGNC:BDNF) increases surf(p(HGNC:CHRNA7))
pmid:28632203 p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:28745240 act(p(HGNC:SRC)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42))
pmid:19293145 p(HGNC:SRC) increases bp(MESH:Neuroprotection)
pmid:24653673 p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307))
pmid:24653673 p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307))
pmid:24653673 p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307))
pmid:24653673 p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307))
pmid:29191965 p(HGNC:SRC) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))
pmid:26751493 p(HGNC:SRC) association p(HBP:"projection domain")
pmid:18467332 p(HGNC:SRC) isA complex(p(HGNC:MAPT), p(HGNC:SRC))
pmid:26751493 p(HGNC:SRC) association a(HBP:"projection domain")
pmid:28745240 p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 act(p(HGNC:LCK)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42))
pmid:30640040 p(HGNC:LCK) association a(PUBCHEM:4878)
pmid:29191965 p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))
pmid:26751493 p(HGNC:LCK) association p(HBP:"projection domain")
pmid:26631930 p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:26751493 p(HGNC:LCK) association a(HBP:"projection domain")
pmid:28745240 p(HGNC:RELA, pmod(Ph, Ser, 536)) negativeCorrelation bp(MESH:"Neuronal Outgrowth")
pmid:28745240 bp(GO:"axon guidance") increases bp(GO:neurogenesis)
pmid:28745240 bp(GO:"axon guidance") increases a(GO:axon)
pmid:28745240 p(HGNC:ITGB1) increases bp(GO:"axon guidance")
pmid:28745240 p(HGNC:ITGB1) increases a(GO:axon)
pmid:21214928 p(HGNC:ITGB1) association p(HGNC:APP)
pmid:28745240 p(HGNC:NCAM1) increases a(GO:axon)
pmid:28745240 p(HGNC:SLITRK1) increases a(GO:axon)
pmid:28745240 p(HGNC:GFRA1) increases a(GO:axon)
pmid:28745240 p(HGNC:TIAM1) increases a(GO:axon)
pmid:22020111 act(a(MESH:"Dendritic Cells")) increases bp(GO:"T cell activation")
pmid:28745240 p(HGNC:HES1) increases a(GO:"dendritic branch")
pmid:28745240 p(HGNC:HES1) increases a(MESH:"Dendritic Cells")
pmid:28745240 p(HGNC:HES5) increases a(GO:"dendritic branch")
pmid:28745240 p(HGNC:HES5) increases a(MESH:"Dendritic Cells")
pmid:28745240 p(HGNC:MAP1B) increases a(MESH:"Dendritic Cells")
pmid:28745240 p(HGNC:MAP2) increases a(MESH:"Dendritic Cells")
pmid:28745240 complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:IL1B) increases bp(GO:"neuron death")
pmid:27288790 p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24561250 p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27314526 p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:27288790 p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:27288790 p(HGNC:IL1B) increases p(FPLX:"IKK_complex", pmod(Ph))
pmid:27288790 p(HGNC:IL1B) increases p(HGNC:RELA, pmod(Ph))
pmid:27288790 p(HGNC:IL1B) decreases p(FPLX:IKB)
pmid:27288790 p(HGNC:IL1B) increases a(MESH:Cytokines)
pmid:27288790 p(HGNC:IL1B) increases a(MESH:Chemokines)
pmid:23702978 act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation")
pmid:24561250 p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex")
pmid:24561250 p(HGNC:IL1B) increases bp(GO:"inflammatory response")
pmid:27314526 p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia)
pmid:27314526 p(HGNC:IL1B) increases bp(GO:"microglial cell activation")
pmid:27314526 p(HGNC:IL1B) increases bp(GO:"astrocyte activation")
pmid:27314526 sec(p(HGNC:IL1B)) increases p(HGNC:APP)
pmid:27314526 sec(p(HGNC:IL1B)) increases a(CHEBI:"amyloid-beta")
pmid:28745240 bp(GO:"p38MAPK cascade") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:25514383 bp(GO:"p38MAPK cascade") increases a(HBP:"Tau aggregates")
pmid:27314526 bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle")
pmid:28784767 p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) increases a(HBP:"Tau Protein Secondary Structure, Turn")
pmid:21882945 p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26118667 complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5))
pmid:28745240 act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:30444369 p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(HGNC:CDK5) association path(MESH:"Alzheimer Disease")
pmid:8282104 p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30444369 p(HGNC:CDK5) increases p(HGNC:PRDX2, pmod(Ph, Thr, 89))
pmid:22122372 p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 654))
pmid:22122372 p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 668))
pmid:22122372 p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Ser, 665))
pmid:24653673 act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton")
pmid:24653673 act(p(HGNC:CDK5)) negativeCorrelation a(GO:"neurofilament cytoskeleton")
pmid:24653673 act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:APP, pmod(Ph))
pmid:24653673 act(p(HGNC:CDK5)) negativeCorrelation bp(HBP:"APP processing")
pmid:24653673 act(p(HGNC:CDK5)) negativeCorrelation bp(GO:neurogenesis)
pmid:24653673 act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity")
pmid:24653673 act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"apoptotic process")
pmid:12428809 p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph))
pmid:29758300 p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph))
pmid:8282104 p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:21882945 act(p(HGNC:CDK5)) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:29191965 p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:27314526 p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph))
pmid:8282104 p(HGNC:CDK5) directlyIncreases p(HBP:HBP00053, pmod(Ph))
pmid:8282104 p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:17078951 act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:8282104 p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:8282104 p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235))
pmid:8282104 p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:8282104 p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:8282104 p(HGNC:CDK5) association a(GO:microtubule)
pmid:8282104 p(HGNC:CDK5) association a(HBP:HBP00006)
pmid:8282104 p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph))))
pmid:21882945 p(HGNC:CDK5) increases act(p(HGNC:MARK2))
pmid:21367866 act(p(HGNC:CDK5)) positiveCorrelation p(HGNC:CDC37)
pmid:27796283 p(HGNC:CDK5) increases p(HGNC:CAMKV, pmod(Ph, Thr, 345))
pmid:17078951 act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:17078951 act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:17078951 act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17078951 act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:17078951 act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202)))
pmid:17078951 act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212)))
pmid:17078951 act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217)))
pmid:17078951 act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404)))
pmid:17078951 act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396)))
pmid:8702879 act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551))
pmid:8702879 act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 553))
pmid:26118667 p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1))
pmid:25001178 act(p(HGNC:CDK5), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:25001178 act(p(HGNC:CDK5), ma(kin)) positiveCorrelation act(p(HGNC:MAPK1), ma(kin))
pmid:21548880 p(HGNC:CDK5R1) increases act(p(HGNC:CDK5))
pmid:26118667 p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1))
pmid:26118667 p(HGNC:CDK5R1) negativeCorrelation p(HBP:"CDK5R1 p25")
pmid:19126755 path(HBP:neurotoxicity) association a(CHEBI:nicotine)
pmid:19293145 path(HBP:neurotoxicity) association a(HBP:"amyloid-beta oligomers")
pmid:19293145 path(HBP:neurotoxicity) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:22908190 path(HBP:neurotoxicity) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42")
pmid:24027553 path(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau aggregates")
pmid:25652642 bp(HBP:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex"))
pmid:24653673 bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:GSK3B))
pmid:24653673 bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:CDK5))
pmid:24653673 bp(HBP:"APP processing") negativeCorrelation act(p(FPLX:ERK))
pmid:24027553 bp(HBP:"APP processing") association p(HGNC:HTRA1)
pmid:24027553 bp(HBP:"APP processing") association path(MESH:"Alzheimer Disease")
pmid:28745240 complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) increases p(HGNC:BACE1)
pmid:28745240 complex(p(HGNC:NFKB2), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA))
pmid:28745240 complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) increases p(HGNC:BACE1)
pmid:28745240 complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) decreases p(HGNC:BACE1)
pmid:28745240 complex(p(HGNC:NFKB2), p(HGNC:REL)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:REL))
pmid:28745240 complex(GO:"gamma-secretase complex") regulates p(HBP:C99)
pmid:29758300 complex(GO:"gamma-secretase complex") increases p(HGNC:APP, frag("?"))
pmid:14556719 complex(GO:"gamma-secretase complex") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")))
pmid:14556719 act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN1, var("?"))
pmid:14556719 act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?"))
pmid:21214928 p(HGNC:PSEN1) regulates p(HGNC:APP)
pmid:19293145 p(HGNC:PSEN1) causesNoChange path(HBP:Neurodegeneration)
pmid:19293145 p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:PSEN1) association bp(GO:"calcium ion homeostasis")
pmid:29758300 p(HGNC:PSEN1) association bp(GO:"regulation of lysosomal lumen pH")
pmid:22908190 p(HGNC:PSEN1) increases bp(GO:"pH reduction")
pmid:22908190 p(HGNC:PSEN1) increases act(a(MESH:Cathepsins))
pmid:22908190 p(HGNC:PSEN1) increases p(HGNC:ATP6V0A1, pmod(NGlyco))
pmid:24027553 p(HGNC:PSEN1) association path(MESH:"Alzheimer disease, familial, type 3")
pmid:24027553 p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification")
pmid:28745240 act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) increases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:SIRT1) decreases act(complex(GO:"NF-kappaB complex"))
pmid:28745240 p(HGNC:SIRT1) decreases path(HBP:neurotoxicity)
pmid:22020111 p(HGNC:SIRT1) decreases p(HGNC:NFE2L2, pmod(Ac))
pmid:30116051 p(HGNC:SIRT1) increases bp(GO:macroautophagy)
pmid:30116051 act(p(HGNC:SIRT1)) decreases act(p(FPLX:mTORC1))
pmid:30116051 act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO1))
pmid:30116051 act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO3))
pmid:30116051 act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG5))
pmid:30116051 act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG7))
pmid:30116051 act(p(HGNC:SIRT1)) increases act(p(HGNC:MAP1LC3A))
pmid:26631930 p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(Ac, Lys))
pmid:20869593 act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac))
pmid:20869593 act(p(HGNC:SIRT1)) negativeCorrelation p(HBP:"Tau epitope, AT8")
pmid:29540553 act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174))
pmid:29540553 act(p(HGNC:SIRT1)) negativeCorrelation a(HBP:"Pathological Tau Spreading")
pmid:29540553 act(p(HGNC:SIRT1)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29540553 p(HGNC:SIRT1) positiveCorrelation bp(GO:learning)
pmid:29540553 p(HGNC:SIRT1) positiveCorrelation bp(GO:memory)
pmid:29226865 act(p(HGNC:SIRT1)) directlyDecreases p(HGNC:SRSF2, pmod(Ac, Lys, 52))
pmid:28745240 a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex"))
pmid:19293145 a(MESH:Calcineurin) association act(a(CHEBI:nicotine))
pmid:19293145 a(MESH:Calcineurin) association bp(MESH:Neuroprotection)
pmid:28745240 p(HGNC:CXCL8) increases bp(GO:"neuron death")
pmid:27288790 p(FPLX:ERK) increases act(p(FPLX:NFkappaB))
pmid:19293145 p(FPLX:ERK) association a(CHEBI:nicotine)
pmid:24653673 act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton")
pmid:24653673 act(p(FPLX:ERK)) negativeCorrelation a(GO:"neurofilament cytoskeleton")
pmid:24653673 act(p(FPLX:ERK)) negativeCorrelation p(HGNC:APP, pmod(Ph))
pmid:24653673 act(p(FPLX:ERK)) negativeCorrelation bp(HBP:"APP processing")
pmid:24653673 act(p(FPLX:ERK)) negativeCorrelation bp(GO:neurogenesis)
pmid:24653673 act(p(FPLX:ERK)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity")
pmid:24653673 act(p(FPLX:ERK)) positiveCorrelation bp(GO:"apoptotic process")
pmid:12428809 p(FPLX:ERK) increases p(HGNC:MAPT, pmod(Ph))
pmid:8282104 p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:8282104 p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:8282104 p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:8282104 p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235))
pmid:8282104 p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:8282104 p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:8282104 p(FPLX:ERK) association a(GO:microtubule)
pmid:8282104 p(FPLX:ERK) association a(HBP:HBP00006)
pmid:8282104 p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph))))
pmid:8282104 p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27594586 p(FPLX:ERK) regulates p(HGNC:MMP9)
pmid:24686445 act(p(FPLX:ERK)) positiveCorrelation act(p(HGNC:KAT2B))
pmid:29179999 path(HP:Neurodegeneration) association act(p(FPLX:NFkappaB))
pmid:27491084 path(HP:Neurodegeneration) association p(HGNC:ATXN3, var("?"))
pmid:27491084 path(HP:Neurodegeneration) association p(HGNC:AR, var("?"))
pmid:27491084 path(HP:Neurodegeneration) association p(HGNC:SNCA, var("?"))
pmid:24563850 act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:radical)
pmid:24563850 act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive oxygen species")
pmid:24563850 act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive nitrogen species")
pmid:27288790 p(HGNC:PTGS2) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 p(HGNC:PTGS2) association a(HBP:"amyloid-beta aggregates")
pmid:27288790 p(HGNC:PTGS2) increases path(MESH:Inflammation)
pmid:19126755 act(p(HGNC:PTGS2)) increases a(CHEBI:"prostaglandin H2")
pmid:19126755 p(HGNC:PTGS2, loc(MESH:Neurons)) regulates path(MESH:"Neuronal Plasticity")
pmid:19126755 p(HGNC:PTGS2, loc(MESH:Neurons)) regulates bp(GO:"cell death")
pmid:19126755 p(HGNC:PTGS2) association p(HGNC:CHRNA4)
pmid:27314526 sec(a(MESH:Interleukins)) association path(MESH:Dementia)
pmid:27314526 sec(a(MESH:Interleukins)) association bp(HBP:neuroinflammation)
pmid:29179999 a(CHEBI:curcumin) decreases bp(GO:"inflammatory response")
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:PTGS2)
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:LOX)
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:NOS2)
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:TNF)
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:IL1A)
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:IL2)
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:IL6)
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:CXCL8)
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:IL12B)
pmid:29179999 a(CHEBI:curcumin) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:curcumin) decreases p(HGNC:NFKBIA, pmod(Ph))
pmid:29179999 a(CHEBI:curcumin) decreases deg(p(HGNC:NFKBIA))
pmid:29179999 a(CHEBI:curcumin) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:28803412 a(CHEBI:curcumin) decreases a(HBP:HBP00092)
pmid:28803412 a(CHEBI:curcumin) decreases a(HBP:HBP00016)
pmid:30116051 a(CHEBI:curcumin) decreases a(HBP:HBP00016)
pmid:28803412 a(CHEBI:curcumin) decreases a(HBP:HBP00018)
pmid:30116051 a(CHEBI:curcumin) increases bp(GO:macroautophagy)
pmid:30116051 a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1))
pmid:30116051 a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr")))
pmid:30116051 a(CHEBI:curcumin) decreases a(HBP:HBP00022)
pmid:30116051 a(CHEBI:curcumin) decreases a(HBP:HBP00009)
pmid:27288790 p(HGNC:NOS2) increases path(MESH:Inflammation)
pmid:23702978 act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide")
pmid:27314526 act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide")
pmid:27288790 p(HGNC:NFKBIA, pmod(Ph)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:29179999 a(CHEBI:resveratrol) decreases p(HGNC:TNF)
pmid:29179999 a(CHEBI:resveratrol) decreases p(HGNC:PTGS2)
pmid:29179999 a(CHEBI:resveratrol) decreases p(HGNC:PTGS2)
pmid:29179999 a(CHEBI:resveratrol) decreases a(MESH:Interleukins)
pmid:29179999 a(CHEBI:resveratrol) decreases p(FPLX:"IKK_complex", pmod(Ph))
pmid:29179999 a(CHEBI:resveratrol) decreases p(HGNC:NFKBIA, pmod(Ph))
pmid:29179999 a(CHEBI:resveratrol) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:resveratrol) decreases p(HGNC:STAT1, pmod(Ph))
pmid:29179999 a(CHEBI:resveratrol) decreases p(HGNC:STAT3, pmod(Ph))
pmid:29179999 a(CHEBI:resveratrol) decreases a(CHEBI:"nitric oxide")
pmid:29179999 a(CHEBI:resveratrol) decreases p(HGNC:NOS2)
pmid:29179999 a(CHEBI:resveratrol) decreases a(CHEBI:"prostaglandin E2")
pmid:22020111 a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1))
pmid:22020111 a(CHEBI:resveratrol) decreases act(p(HGNC:NFE2L2))
pmid:30116051 a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2))
pmid:30116051 a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta")
pmid:30116051 a(CHEBI:resveratrol) decreases p(HGNC:HTT)
pmid:30116051 a(CHEBI:resveratrol) increases act(p(FPLX:AMPK))
pmid:30116051 a(CHEBI:resveratrol) decreases act(p(HGNC:APP, frag("23_35")))
pmid:30116051 a(CHEBI:resveratrol) increases r(FPLX:ATG4)
pmid:30116051 a(CHEBI:resveratrol) increases bp(GO:"autophagosome assembly")
pmid:30116051 a(CHEBI:resveratrol) decreases p(HGNC:AGER)
pmid:30116051 a(CHEBI:resveratrol) decreases p(HGNC:MMP9)
pmid:30116051 a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:29062069 a(CHEBI:resveratrol) directlyIncreases act(p(HGNC:PPP2CA))
pmid:29062069 a(CHEBI:resveratrol) directlyDecreases p(HGNC:MID1)
pmid:27288790 act(p(FPLX:"IKK_complex")) increases p(FPLX:IKB, pmod(Ph))
pmid:23702978 act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11))
pmid:23178521 p(HGNC:STAT3, pmod(Ph)) association a(CHEBI:nicotine)
pmid:29179999 a(CHEBI:pterostilbene) regulates p(HGNC:PPARA)
pmid:29179999 a(CHEBI:pterostilbene) regulates p(FPLX:NFkappaB)
pmid:29179999 a(CHEBI:pterostilbene) regulates p(FPLX:JNK, pmod(Ph))
pmid:21718217 p(HGNC:PPARA) regulates bp(GO:"lipid oxidation")
pmid:21718217 p(HGNC:PPARA) regulates bp(MESH:"Lipid Peroxidation")
pmid:18494933 p(FPLX:JNK, pmod(Ph)) positiveCorrelation act(p(FPLX:JNK))
pmid:18494933 act(p(FPLX:JNK)) positiveCorrelation p(FPLX:JNK, pmod(Ph))
pmid:18494933 p(FPLX:JNK) positiveCorrelation act(p(HGNC:AGER))
pmid:18494933 p(FPLX:JNK) increases p(HGNC:DKK1)
pmid:18494933 act(p(FPLX:JNK)) increases p(HGNC:DKK1)
pmid:27068745 act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:"1.6.3.1")
pmid:27068745 act(p(FPLX:JNK)) association p(HGNC:CASP3)
pmid:29179999 a(PUBCHEM:44584733) decreases p(HGNC:PTGS2)
pmid:29179999 a(PUBCHEM:44584733) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB))
pmid:29179999 a(PUBCHEM:44584733) decreases bp(GO:"inflammatory response")
pmid:29179999 a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") decreases bp(GO:"NIK/NF-kappaB signaling")
pmid:29179999 a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:NFKBIA, pmod(Ph))
pmid:29179999 a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:MAPK14, pmod(Ph))
pmid:29179999 a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(FPLX:ERK, pmod(Ph))
pmid:27288790 p(HGNC:MAPK14) increases act(p(FPLX:NFkappaB))
pmid:27288790 act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph))
pmid:27288790 act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph))
pmid:27288790 act(p(HGNC:MAPK14)) increases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:30640040 act(p(HGNC:MAPK14)) increases a(HBP:"Tau aggregates")
pmid:30640040 p(HGNC:MAPK14) association a(PUBCHEM:11570805)
pmid:30640040 p(HGNC:MAPK14) association a(PUBCHEM:156422)
pmid:30640040 p(HGNC:MAPK14) association a(PUBCHEM:10341154)
pmid:11943212 p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:27594586 p(FPLX:ERK, pmod(Ph)) positiveCorrelation act(p(HGNC:MMP9))
pmid:27594586 p(FPLX:ERK, pmod(Ph)) positiveCorrelation sec(p(HGNC:MMP9))
pmid:24686445 p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK))
pmid:29179999 a(CHEBI:Salidroside) increases bp(GO:cognition)
pmid:29179999 a(CHEBI:Salidroside) regulates p(HGNC:TXN)
pmid:29179999 a(CHEBI:Salidroside) regulates p(HGNC:TXNIP)
pmid:29179999 a(CHEBI:Salidroside) regulates p(HGNC:RELA)
pmid:29179999 a(CHEBI:Salidroside) regulates p(HGNC:NFKBIA)
pmid:29179999 a(CHEBI:Salidroside) regulates p(HGNC:CHUK)
pmid:29179999 a(CHEBI:Salidroside) regulates p(HGNC:IKBKB)
pmid:29179999 a(PUBCHEM:155160) increases bp(GO:memory)
pmid:29179999 a(PUBCHEM:155160) decreases a(HBP:"amyloid-beta aggregates")
pmid:29179999 a(PUBCHEM:155160) decreases path(MESH:"Oxidative Stress")
pmid:29179999 a(PUBCHEM:155160) decreases path(MESH:Inflammation)
pmid:29179999 a(PUBCHEM:155160) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:29179999 a(PUBCHEM:155160) decreases act(p(FPLX:"Gamma_secretase"))
pmid:29179999 a(PUBCHEM:155160) decreases act(p(HGNC:BACE1))
pmid:29179999 a(PUBCHEM:155160) decreases act(p(FPLX:NFkappaB))
pmid:27288790 a(HBP:"amyloid-beta aggregates") increases act(p(FPLX:"IKK_complex"))
pmid:27288790 a(HBP:"amyloid-beta aggregates") association p(HGNC:PTGS2)
pmid:30444369 a(HBP:"amyloid-beta aggregates") increases path(HBP:"mitochondrial dysfunction")
pmid:30444369 a(HBP:"amyloid-beta aggregates") decreases act(p(FPLX:COX))
pmid:30444369 a(HBP:"amyloid-beta aggregates") association p(HGNC:CSNK1A1)
pmid:19293145 a(HBP:"amyloid-beta aggregates") association path(MESH:"Alzheimer Disease")
pmid:24590577 a(HBP:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease")
pmid:25514383 a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22817713 a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24511233 a(HBP:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid")
pmid:24590577 a(HBP:"amyloid-beta aggregates") increases path(MESH:"Plaque, Amyloid")
pmid:17009926 a(HBP:"amyloid-beta aggregates") association p(HGNC:CHRNA7)
pmid:27491084 a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB1)
pmid:27491084 a(HBP:"amyloid-beta aggregates") association p(HGNC:CRYAB)
pmid:27491084 a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB6)
pmid:27491084 a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB8)
pmid:28877763 a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK))
pmid:28877763 a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK))
pmid:28877763 a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK))
pmid:29179999 a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"neuron death")
pmid:27288790 a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(Ph, Ser, 32))
pmid:27288790 a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(Ph, Ser, 36))
pmid:27288790 a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:NFkappaB, pmod(Ph, Ser, 536))
pmid:27288790 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:BACE1)
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:BACE1)
pmid:27288790 a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:"BACE1-AS")
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:APP)
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex"))
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex"))
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") increases complex(p(HGNC:NFKB1), p(HGNC:RELA))
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") regulates bp(GO:"cell death")
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation act(a(MESH:Microglia))
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"positive regulation of advanced glycation end-product receptor activity")
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"peroxisome proliferator activated receptor signaling pathway")
pmid:25652642 a(CHEBI:"amyloid-beta polypeptide 42") increases p(MESH:"I-kappa B Proteins", pmod(Ph))
pmid:29196815 a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease")
pmid:26195256 a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease")
pmid:19126755 a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 a(CHEBI:"amyloid-beta polypeptide 42") increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials")
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials")
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN))
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN))
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:25514383 a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"long-term synaptic potentiation")
pmid:19721446 a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity)
pmid:19721446 a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity)
pmid:22908190 a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation path(HBP:neurotoxicity)
pmid:22908190 a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity)
pmid:19721446 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine))
pmid:19721446 a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection)
pmid:14556719 a(CHEBI:"amyloid-beta polypeptide 42") increases a(HBP:"amyloid-beta fibrils")
pmid:22908190 tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation bp(GO:endocytosis)
pmid:22908190 tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation g(HBP:"APOE e4")
pmid:22908190 tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol")
pmid:22908190 a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:26195256 a(CHEBI:"amyloid-beta polypeptide 42") isA a(CHEBI:"amyloid-beta")
pmid:30116051 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK))
pmid:30116051 a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"autophagosome assembly")
pmid:30116051 a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:30116051 a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy")
pmid:30116051 a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy")
pmid:30116051 a(CHEBI:"amyloid-beta polypeptide 42") decreases a(GO:microtubule)
pmid:30116051 a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:IDE)
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1)
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:AK1)
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1)
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNC:AK1))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:Tauopathies)
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(HGNC:AK3)
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:AK1)
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 171))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(ECCODE:"2.7.11.31")
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(ECCODE:"2.7.11.31"))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(ECCODE:"2.7.11.31"))
pmid:22419736 a(CHEBI:"amyloid-beta polypeptide 42") decreases p(MESH:"Acetyl-CoA Carboxylase", pmod(Ph))
pmid:29626319 a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:TREM2)
pmid:30444369 p(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")))
pmid:29179999 a(CHEBI:lycopene) increases path(MESH:"Spatial Learning")
pmid:29179999 a(CHEBI:lycopene) increases bp(GO:memory)
pmid:29179999 a(CHEBI:lycopene) decreases bp(GO:"NIK/NF-kappaB signaling")
pmid:29179999 a(CHEBI:genistein) decreases p(HGNC:TLR4)
pmid:29179999 a(CHEBI:genistein) decreases p(FPLX:NFkappaB)
pmid:29179999 a(CHEBI:genistein) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:genistein) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB))
pmid:19293145 a(CHEBI:genistein) decreases act(a(CHEBI:"amyloid-beta"))
pmid:19293145 a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)"))
pmid:19293145 a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph))
pmid:17009926 a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph))
pmid:17009926 a(CHEBI:genistein) causesNoChange surf(p(FPLX:CHRN))
pmid:17009926 a(CHEBI:genistein) regulates p(FPLX:CHRN)
pmid:27314526 p(HGNC:TLR4) increases bp(GO:"cytokine secretion")
pmid:29179999 a(PUBCHEM:45270574) decreases act(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:29179999 a(CHEBI:"gallic acid") decreases act(p(FPLX:MYST))
pmid:29179999 a(CHEBI:"gallic acid") decreases p(HGNC:RELA, pmod(Ac))
pmid:29179999 a(CHEBI:"gallic acid") decreases path(MESH:Inflammation)
pmid:29179999 a(CHEBI:"gallic acid") decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:"gallic acid") decreases act(a(CHEBI:"amyloid-beta"))
pmid:29179999 a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE))
pmid:19126755 a(CHEBI:galanthamine) decreases p(HGNC:ACHE)
pmid:11230871 a(CHEBI:galanthamine) increases act(p(HGNC:ACHE))
pmid:29179999 a(CHEBI:galanthamine) increases a(CHEBI:acetylcholine)
pmid:29179999 a(CHEBI:galanthamine) increases sec(a(CHEBI:acetylcholine))
pmid:29179999 a(CHEBI:galanthamine) increases act(p(HGNC:HMOX1))
pmid:29179999 a(CHEBI:galanthamine) increases act(p(FPLX:NFkappaB))
pmid:30444369 a(CHEBI:galanthamine) increases bp(GO:cognition)
pmid:26813123 a(CHEBI:galanthamine) increases bp(GO:cognition)
pmid:30444369 a(CHEBI:galanthamine) decreases act(p(FPLX:Cholinesterase))
pmid:19126755 a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:galanthamine) decreases path(HBP:Neurodegeneration)
pmid:19126755 a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic")
pmid:19293145 a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor")
pmid:19293145 a(CHEBI:galanthamine) decreases path(MESH:"Alzheimer Disease")
pmid:19293145 act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection)
pmid:19293145 a(CHEBI:galanthamine) increases p(HGNC:BCL2)
pmid:24511233 a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")
pmid:17009926 a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")
pmid:17009926 a(CHEBI:galanthamine) increases act(p(FPLX:CHRN))
pmid:26813123 a(CHEBI:galanthamine) decreases path(MESH:Death)
pmid:25881725 a(CHEBI:galanthamine) decreases act(p(MGI:App, frag("25_35")))
pmid:25881725 a(CHEBI:galanthamine) increases bp(GO:learning)
pmid:25881725 a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory")
pmid:25881725 a(CHEBI:galanthamine) causesNoChange r(MGI:Chrna7)
pmid:25881725 a(CHEBI:galanthamine) increases p(MGI:Chrna7)
pmid:25881725 a(CHEBI:galanthamine) increases p(MGI:Chrna7)
pmid:19721446 a(CHEBI:galanthamine) regulates p(HGNC:CHRNA7)
pmid:19721446 a(CHEBI:galanthamine) decreases path(MESH:Schizophrenia)
pmid:19126755 p(HGNC:ACHE) decreases act(a(CHEBI:nicotine))
pmid:19293145 p(HGNC:ACHE) decreases a(CHEBI:acetylcholine)
pmid:17009926 act(p(HGNC:ACHE), ma(pep)) directlyIncreases deg(a(CHEBI:acetylcholine))
pmid:26813123 p(HGNC:ACHE) decreases act(a(CHEBI:acetylcholine))
pmid:21482353 p(HGNC:ACHE) increases deg(a(CHEBI:acetylcholine))
pmid:23038257 p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine))
pmid:17009926 act(p(HGNC:ACHE), ma(pep)) directlyIncreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline)))
pmid:26813123 p(HGNC:ACHE) increases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline)))
pmid:26813123 p(HGNC:ACHE) association path(MESH:"Alzheimer Disease")
pmid:11230871 act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26813123 p(HGNC:ACHE) increases a(CHEBI:"amyloid-beta")
pmid:25514383 act(p(HGNC:ACHE)) increases bp(GO:"acetylcholine catabolic process")
pmid:21482353 act(p(HGNC:ACHE)) decreases bp(GO:"synaptic transmission, cholinergic")
pmid:18986241 p(HGNC:ACHE) association path(MESH:D058225)
pmid:18986241 p(HGNC:ACHE) increases bp(GO:"GO:1990000")
pmid:19126755 a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic"))
pmid:24590577 a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic"))
pmid:19126755 a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:24590577 a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:acetylcholine) decreases path(MESH:"Heart Rate")
pmid:19126755 a(CHEBI:acetylcholine) association bp(GO:signaling)
pmid:24511233 a(CHEBI:acetylcholine) regulates act(a(MESH:Neurons))
pmid:24511233 act(a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRM1))
pmid:17009926 deg(a(CHEBI:acetylcholine)) decreases act(a(CHEBI:acetylcholine))
pmid:17009926 a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7))
pmid:17009926 a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate")
pmid:26813123 a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter)
pmid:26813123 a(CHEBI:acetylcholine) positiveCorrelation bp(GO:memory)
pmid:26813123 a(CHEBI:acetylcholine) regulates bp(GO:memory)
pmid:26813123 a(CHEBI:acetylcholine) association bp(GO:memory)
pmid:26813123 a(CHEBI:acetylcholine) regulates a(MESH:"Hypothalamo-Hypophyseal System")
pmid:26813123 a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic"))
pmid:26813123 a(CHEBI:acetylcholine) increases bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 a(CHEBI:acetylcholine) increases bp(GO:neurogenesis)
pmid:26813123 a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM))
pmid:21482353 a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM))
pmid:26813123 a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN))
pmid:21482353 a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN))
pmid:21787755 a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN))
pmid:26813123 deg(a(CHEBI:acetylcholine)) increases a(CHEBI:choline)
pmid:26813123 a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission")
pmid:26813123 a(CHEBI:acetylcholine) regulates bp(GO:"synaptic transmission, glutamatergic")
pmid:26813123 a(CHEBI:acetylcholine) association bp(GO:learning)
pmid:26813123 a(CHEBI:acetylcholine) association bp(GO:cognition)
pmid:11230871 a(CHEBI:acetylcholine) negativeCorrelation bp(GO:cognition)
pmid:16273023 a(CHEBI:acetylcholine) increases complex(a(CHEBI:acetylcholine), p(MESH:D011950))
pmid:25514383 tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) regulates bp(GO:"long-term memory")
pmid:25514383 a(CHEBI:acetylcholine) increases act(a(HBP:"beta-2-containing nAChR"))
pmid:25514383 act(a(CHEBI:acetylcholine)) increases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:21482353 a(CHEBI:acetylcholine) increases act(a(HBP:"alpha-7-containing nAChR"))
pmid:19721446 a(CHEBI:acetylcholine) association bp(GO:"regulation of cation channel activity")
pmid:29179999 complex(a(CHEBI:galanthamine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN))
pmid:17009926 p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion")
pmid:17009926 act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion")
pmid:17009926 p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion")
pmid:17009926 p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation")
pmid:17009926 p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation")
pmid:17009926 p(FPLX:CHRN) regulates bp(GO:"neuron remodeling")
pmid:17009926 p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity")
pmid:17009926 act(p(FPLX:CHRN)) increases bp(GO:"regulation of synaptic plasticity")
pmid:17009926 p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity")
pmid:17009926 p(FPLX:CHRN) association path(MESH:Attention)
pmid:17009926 p(FPLX:CHRN) association bp(GO:learning)
pmid:17009926 p(FPLX:CHRN) association bp(GO:memory)
pmid:11230871 p(FPLX:CHRN) association bp(GO:memory)
pmid:17009926 p(FPLX:CHRN) association bp(GO:"developmental process")
pmid:17009926 p(FPLX:CHRN) association path(MESH:Schizophrenia)
pmid:17009926 p(FPLX:CHRN) association path(MESH:Schizophrenia)
pmid:21482353 act(p(FPLX:CHRN)) association path(MESH:Schizophrenia)
pmid:11230871 p(FPLX:CHRN) association path(MESH:Schizophrenia)
pmid:17009926 p(FPLX:CHRN) association path(MESH:Epilepsy)
pmid:17009926 p(FPLX:CHRN) association path(MESH:Epilepsy)
pmid:11230871 p(FPLX:CHRN) association path(MESH:Epilepsy)
pmid:17009926 p(FPLX:CHRN) association path(MESH:"Autistic Disorder")
pmid:17009926 act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder")
pmid:17009926 p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder")
pmid:17009926 p(FPLX:CHRN) association path(MESH:"Alzheimer Disease")
pmid:17009926 act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:17009926 p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:17009926 p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:11230871 p(FPLX:CHRN) association path(MESH:"Alzheimer Disease")
pmid:11230871 p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:17009926 p(FPLX:CHRN) association path(MESH:"Behavior, Addictive")
pmid:26472524 act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive")
pmid:17009926 p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:17009926 p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:17009926 p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:17009926 p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:17009926 act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization")
pmid:17009926 act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization")
pmid:17009926 act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization")
pmid:26472524 act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization")
pmid:17009926 act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:25514383 act(p(FPLX:CHRN)) increases a(CHEBI:"calcium(2+)")
pmid:17009926 act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)"))
pmid:17009926 p(FPLX:CHRN) increases sec(a(CHEBI:"glutamate(2-)"))
pmid:26472524 act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)"))
pmid:17009926 p(FPLX:CHRN) increases sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:17009926 p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex"))
pmid:17009926 act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression")
pmid:17009926 act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate")
pmid:17009926 p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate")
pmid:17009926 p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate")
pmid:17009926 p(FPLX:CHRN) association bp(GO:"regulation of action potential firing pattern")
pmid:17009926 act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Lewy Body Disease")
pmid:17009926 p(FPLX:CHRN) negativeCorrelation path(MESH:"Lewy Body Disease")
pmid:17009926 act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome")
pmid:17009926 p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome")
pmid:17009926 act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Parkinson Disease")
pmid:17009926 p(FPLX:CHRN) negativeCorrelation path(MESH:"Parkinson Disease")
pmid:11230871 p(FPLX:CHRN) association path(MESH:"Parkinson Disease")
pmid:17009926 p(FPLX:CHRN) association bp(GO:"response to pain")
pmid:17009926 p(FPLX:CHRN) association path(MESH:Anxiety)
pmid:11230871 p(FPLX:CHRN) association path(MESH:Anxiety)
pmid:17009926 p(FPLX:CHRN) association path(MESH:Depression)
pmid:11230871 p(FPLX:CHRN) association path(MESH:Depression)
pmid:17009926 act(p(FPLX:CHRN)) increases path(MESH:Arousal)
pmid:28445721 p(FPLX:CHRN) association path(MESH:Arousal)
pmid:17009926 act(p(FPLX:CHRN)) increases bp(GO:"circadian sleep/wake cycle, REM sleep")
pmid:26472524 p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:26472524 p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:26813123 p(FPLX:CHRN) increases bp(GO:cognition)
pmid:25514383 p(FPLX:CHRN) regulates bp(GO:cognition)
pmid:28445721 p(FPLX:CHRN) association bp(GO:cognition)
pmid:28445721 p(FPLX:CHRN) increases bp(GO:cognition)
pmid:28445721 p(FPLX:CHRN) association bp(GO:cognition)
pmid:11230871 p(FPLX:CHRN) association bp(GO:cognition)
pmid:26813123 p(FPLX:CHRN) decreases bp(HBP:Neurodegeneration)
pmid:25514383 p(FPLX:CHRN) isA a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors")
pmid:25514383 p(FPLX:CHRN) regulates bp(GO:"potassium ion transport")
pmid:25514383 p(FPLX:CHRN) regulates bp(GO:"sodium ion transport")
pmid:25514383 p(FPLX:CHRN) regulates bp(GO:"calcium ion transport")
pmid:25514383 act(p(FPLX:CHRN)) increases bp(MESH:"Synaptic Potentials")
pmid:25514383 p(FPLX:CHRN) regulates path(MESH:"Cognition Disorders")
pmid:28445721 p(FPLX:CHRN) association path(MESH:Motivation)
pmid:28445721 act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons"))
pmid:28445721 p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity")
pmid:28445721 p(FPLX:CHRN) increases bp(GO:"dopamine secretion")
pmid:28445721 p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder")
pmid:21482353 act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder")
pmid:21482353 p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:11230871 act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:21482353 act(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1))
pmid:21482353 surf(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1))
pmid:21482353 p(FPLX:CHRN) regulates p(HGNC:LYNX1)
pmid:21482353 act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain))
pmid:21482353 act(p(FPLX:CHRN)) negativeCorrelation a(MESH:Neurons)
pmid:21482353 p(FPLX:CHRN) regulates bp(GO:"GABAergic neuron differentiation")
pmid:21482353 p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron"))
pmid:21482353 p(FPLX:CHRN) increases act(p(FPLX:NOS))
pmid:11230871 p(FPLX:CHRN) association a(MESH:"Neurotransmitter Agents")
pmid:11230871 p(FPLX:CHRN) association path(MESH:"Tourette Syndrome")
pmid:11230871 p(FPLX:CHRN) negativeCorrelation path(MESH:"Cognitive Dysfunction")
pmid:11230871 p(FPLX:CHRN) negativeCorrelation p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu"))
pmid:11230871 p(FPLX:CHRN) negativeCorrelation a(MESH:"Amyloid beta-Peptides")
pmid:11230871 p(FPLX:CHRN) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:11230871 p(FPLX:CHRN) negativeCorrelation bp(GO:"response to oxidative stress")
pmid:21787755 p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure")
pmid:21787755 p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance")
pmid:22020111 p(HGNC:HMOX1) increases act(p(HGNC:NFE2L2))
pmid:22020111 p(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29179999 a(PUBCHEM:14193399) decreases a(CHEBI:"nitric oxide")
pmid:29179999 a(PUBCHEM:14193399) decreases p(HGNC:TNF)
pmid:29179999 a(PUBCHEM:14193399) decreases p(HGNC:IL1A)
pmid:29179999 a(PUBCHEM:14193399) decreases p(HGNC:PTGS2)
pmid:29179999 a(PUBCHEM:14193399) decreases p(HGNC:NOS2)
pmid:29179999 a(PUBCHEM:14193399) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(PUBCHEM:14193399) decreases act(p(HGNC:MAPK14))
pmid:29179999 a(PUBCHEM:14193399) decreases a(CHEBI:"reactive oxygen species")
pmid:29179999 a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(PUBCHEM:73078) decreases a(MESH:Cytokines)
pmid:29179999 a(PUBCHEM:73078) decreases deg(p(HGNC:NFKBIA))
pmid:29179999 a(PUBCHEM:73078) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:29179999 a(PUBCHEM:73078) decreases act(p(HGNC:CHUK))
pmid:29179999 a(PUBCHEM:73078) decreases act(p(HGNC:IKBKB))
pmid:29179999 a(PUBCHEM:73078) increases path(MESH:"Spatial Learning")
pmid:29179999 a(PUBCHEM:73078) increases bp(GO:memory)
pmid:29179999 a(PUBCHEM:73078) decreases p(HGNC:IL1B)
pmid:29179999 a(PUBCHEM:73078) decreases p(HGNC:TNF)
pmid:27288790 a(MESH:Cytokines) increases act(p(FPLX:"IKK_complex"))
pmid:27288790 a(MESH:Cytokines) increases m(MIRBASE:"hsa-mir-155")
pmid:29179999 a(CHEBI:berberine) decreases path(MESH:Inflammation)
pmid:29179999 a(CHEBI:berberine) decreases p(HGNC:RELA, pmod(Ph))
pmid:29179999 a(CHEBI:berberine) decreases p(HGNC:RELA)
pmid:29179999 a(CHEBI:berberine) decreases p(HGNC:NFKBIA, pmod(Ph))
pmid:29179999 a(CHEBI:berberine) decreases act(p(HGNC:MAPK14))
pmid:29179999 a(CHEBI:berberine) decreases act(p(FPLX:ERK))
pmid:29179999 a(CHEBI:berberine) decreases act(p(FPLX:AKT))
pmid:29179999 a(CHEBI:oridonin) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:oridonin) increases bp(GO:cognition)
pmid:29179999 a(CHEBI:oridonin) decreases path(MESH:Inflammation)
pmid:29179999 a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB))
pmid:22807490 a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB))
pmid:26010758 a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB))
pmid:26010758 a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB))
pmid:26010758 a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta")
pmid:21958873 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta")
pmid:21958873 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta")
pmid:26010758 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:21958873 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:21958873 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:21958873 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:29179999 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:21958873 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:21958873 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:21958873 a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:22807490 a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response")
pmid:23178521 a(CHEBI:Anatabine) regulates bp(GO:"inflammatory response")
pmid:26010758 a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response")
pmid:26010758 a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response")
pmid:26010758 a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response")
pmid:22807490 a(CHEBI:Anatabine) decreases path(MESH:"Thyroiditis, Autoimmune")
pmid:22807490 a(CHEBI:Anatabine) decreases a(MESH:Thyroglobulin)
pmid:22807490 a(CHEBI:Anatabine) decreases p(HGNC:IL1R2)
pmid:22807490 a(CHEBI:Anatabine) decreases p(HGNC:NOS2)
pmid:22807490 a(CHEBI:Anatabine) decreases p(HGNC:PTGS2)
pmid:22807490 a(CHEBI:Anatabine) decreases bp(GO:"macrophage activation")
pmid:21958873 a(CHEBI:Anatabine) causesNoChange sec(p(HGNC:LDHA))
pmid:21958873 a(CHEBI:Anatabine) decreases sec(p(HBP:"sAPP-beta"))
pmid:21958873 a(CHEBI:Anatabine) causesNoChange sec(p(HBP:"sAPP-alpha"))
pmid:21958873 a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex"))
pmid:21958873 a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex"))
pmid:21958873 a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex"))
pmid:21958873 a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex"))
pmid:21958873 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph))
pmid:21958873 a(CHEBI:Anatabine) decreases r(HGNC:BACE1)
pmid:26010758 a(CHEBI:Anatabine) decreases r(HGNC:BACE1)
pmid:21958873 a(CHEBI:Anatabine) decreases p(HGNC:BACE1)
pmid:21958873 a(CHEBI:Anatabine) decreases p(HGNC:CRP)
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:26010758 a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph))
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph))
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph))
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph))
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph))
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph))
pmid:23178521 a(CHEBI:Anatabine) decreases p(MGI:Tnf)
pmid:23383175 a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf)
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Tnf)
pmid:23178521 a(CHEBI:Anatabine) decreases p(MGI:Il6)
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Il6)
pmid:23383175 a(CHEBI:Anatabine) decreases a(MESH:Cytokines)
pmid:23383175 a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis)
pmid:23383175 a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis)
pmid:23383175 a(CHEBI:Anatabine) decreases path(MESH:Paralysis)
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases path(MESH:Paralysis)
pmid:23383175 a(CHEBI:Anatabine) decreases path(HP:"Limb muscle weakness")
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Il1b)
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Il1b)
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Il17a)
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Il17a)
pmid:23383175 a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng)
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Ifng)
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph))
pmid:23383175 a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph))
pmid:23383175 a(CHEBI:Anatabine) causesNoChange bp(HBP:Astrogliosis)
pmid:23383175 a(CHEBI:Anatabine) decreases bp(HBP:Astrogliosis)
pmid:23383175 a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis)
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis)
pmid:23383175 a(CHEBI:Anatabine) decreases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord"))
pmid:23383175 a(CHEBI:Anatabine) decreases a(MESH:Microglia)
pmid:23383175 a(CHEBI:Anatabine) decreases tloc(a(MESH:Microglia), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord"))
pmid:23383175 a(CHEBI:Anatabine) decreases tloc(a(MESH:Macrophages), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord"))
pmid:23383175 a(CHEBI:Anatabine) positiveCorrelation a(GO:"myelin sheath")
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) increases bp(GO:"motor behavior")
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) increases bp(GO:"motor behavior")
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases path(MESH:Anxiety)
pmid:26010758 a(CHEBI:Anatabine) increases path(MESH:Anxiety)
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) increases path(MESH:"Spatial Learning")
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) causesNoChange p(HGNC:MAPT)
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231))
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases a(GO:"neurofibrillary tangle")
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases a(HBP:"Tau oligomers")
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) decreases a(HBP:"Tau oligomers")
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
DOI:10.4172/2168-975X.1000126 a(CHEBI:Anatabine) increases p(FPLX:AKT, pmod(Ph, Ser, 473))
pmid:26010758 a(CHEBI:Anatabine) decreases path(MESH:Gliosis)
pmid:26010758 a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph))
pmid:26010758 a(CHEBI:Anatabine) increases act(p(HGNC:CHRNA7))
pmid:26010758 a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3))
pmid:26010758 a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3))
pmid:26010758 a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3))
pmid:26010758 a(CHEBI:Anatabine) decreases bp(GO:locomotion)
pmid:26010758 a(CHEBI:Anatabine) increases path(MESH:"Interpersonal Relations")
pmid:26010758 a(CHEBI:Anatabine) decreases p(HGNC:AIF1)
pmid:26010758 a(CHEBI:Anatabine) decreases bp(GO:"microglial cell activation")
pmid:26010758 a(CHEBI:Anatabine) decreases p(HGNC:PTPRC)
pmid:26010758 a(CHEBI:Anatabine) decreases p(FPLX:NFkappaB, pmod(Ph, Ser, 536))
pmid:26010758 a(CHEBI:Anatabine) decreases r(HGNC:PTGS2)
pmid:26010758 a(CHEBI:Anatabine) decreases r(HGNC:NOS2)
pmid:29179999 a(CHEBI:"vitamin D") decreases p(FPLX:NFkappaB, pmod(Ph))
pmid:29179999 a(CHEBI:"vitamin D") decreases a(CHEBI:"reactive oxygen species")
pmid:29179999 a(CHEBI:"vitamin D") decreases path(MESH:Inflammation)
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"reactive oxygen species")
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases a(MESH:Cytokines)
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"nitric oxide")
pmid:29179999 a(CHEBI:"alpha-tocopherol") increases bp(GO:memory)
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases path(MESH:"Oxidative Stress")
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases p(HGNC:NOS2)
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases p(HGNC:IL6)
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases p(HGNC:IL1B)
pmid:29179999 a(CHEBI:"alpha-tocopherol") decreases bp(GO:"microglial cell activation")
pmid:21718217 bp(GO:"microglial cell activation") association a(HBP:HBP00089)
pmid:21718217 bp(GO:"microglial cell activation") positiveCorrelation a(HBP:HBP00089)
pmid:26010758 bp(GO:"microglial cell activation") positiveCorrelation p(HGNC:AIF1)
pmid:28877763 bp(GO:"microglial cell activation") positiveCorrelation act(p(HGNC:SYK))
pmid:27314526 bp(GO:"microglial cell activation") increases sec(p(HGNC:IL1B))
pmid:27314526 bp(GO:"microglial cell activation") increases sec(p(HGNC:IL6))
pmid:27314526 bp(GO:"microglial cell activation") increases sec(p(HGNC:IL18))
pmid:27314526 bp(GO:"microglial cell activation") increases sec(p(HGNC:NOS2))
pmid:29179999 a(PUBCHEM:444795) decreases path(MESH:Inflammation)
pmid:29179999 a(PUBCHEM:444795) decreases p(HGNC:IL6)
pmid:29179999 a(PUBCHEM:444795) decreases p(HGNC:IL12B)
pmid:29179999 a(PUBCHEM:444795) decreases p(HGNC:TNF)
pmid:29179999 a(PUBCHEM:444795) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(PUBCHEM:444795) decreases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:29179999 a(PUBCHEM:444795) decreases p(HGNC:BACE1)
pmid:29179999 a(PUBCHEM:3086007) decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(PUBCHEM:441921) decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(PUBCHEM:9918693) decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(PUBCHEM:441923) decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(PUBCHEM:441923) decreases r(HGNC:TLR3)
pmid:29179999 a(PUBCHEM:441923) decreases p(HGNC:TLR3)
pmid:29179999 a(PUBCHEM:441923) decreases r(HGNC:TLR4)
pmid:29179999 a(PUBCHEM:441923) decreases p(HGNC:TLR4)
pmid:29179999 a(PUBCHEM:441923) decreases p(FPLX:NFkappaB)
pmid:29179999 a(PUBCHEM:441923) decreases r(HGNC:TRAF6)
pmid:29179999 a(PUBCHEM:441923) decreases p(HGNC:TRAF6)
pmid:29179999 a(PUBCHEM:441923) decreases p(HGNC:TNF)
pmid:29179999 a(PUBCHEM:441923) decreases p(HGNC:IFNB1)
pmid:29179999 a(PUBCHEM:24721561) decreases bp(GO:"neuron death")
pmid:29179999 a(PUBCHEM:24721561) increases bp(GO:learning)
pmid:29179999 a(PUBCHEM:24721561) increases bp(GO:memory)
pmid:29179999 a(PUBCHEM:24721561) decreases act(p(FPLX:NFkappaB))
pmid:26631930 p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(UbK63))
pmid:29179999 a(PUBCHEM:164676) decreases act(p(HGNC:NOS2))
pmid:29179999 a(PUBCHEM:164676) decreases act(p(HGNC:MMP2))
pmid:29179999 a(PUBCHEM:164676) decreases act(p(HGNC:RELA))
pmid:29179999 a(PUBCHEM:164676) decreases path(MESH:"Alzheimer Disease")
pmid:29179999 a(PUBCHEM:164676) decreases bp(GO:"apoptotic process")
pmid:29179999 a(PUBCHEM:164676) decreases path(MESH:Inflammation)
pmid:29179999 a(PUBCHEM:164676) decreases bp(GO:"neuron death")
pmid:29179999 a(PUBCHEM:164676) decreases p(HGNC:GFAP)
pmid:29179999 a(PUBCHEM:164676) decreases p(FPLX:NFkappaB)
pmid:29179999 a(PUBCHEM:164676) increases p(HGNC:RBFOX3)
pmid:29179999 a(PUBCHEM:164676) increases a(MESH:"Nissl Bodies")
pmid:29179999 a(PUBCHEM:164676) increases p(FPLX:IKB)
pmid:27594586 act(p(HGNC:MMP2)) increases bp(GO:"neuron death")
pmid:27594586 p(HGNC:MMP2) increases bp(GO:"neuron death")
pmid:29626319 act(p(HGNC:MMP2)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:25652642 p(HGNC:GFAP) positiveCorrelation m(HGNC:MIR125B1)
pmid:27288790 deg(p(FPLX:IKB)) increases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:"(+)-artemisinin") decreases path(MESH:Inflammation)
pmid:29179999 a(CHEBI:"(+)-artemisinin") decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:"(+)-artemisinin") decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(CHEBI:"(+)-artemisinin") decreases bp(GO:"NLRP3 inflammasome complex assembly")
pmid:28019679 a(CHEBI:"(+)-artemisinin") decreases p(MGI:Nfkbia)
pmid:28019679 a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex")
pmid:29179999 a(PUBCHEM:440312) decreases a(CHEBI:"nitric oxide")
pmid:29179999 a(PUBCHEM:440312) decreases p(HGNC:TNF)
pmid:29179999 a(PUBCHEM:440312) decreases a(CHEBI:"prostaglandin E2")
pmid:29179999 a(PUBCHEM:440312) decreases p(HGNC:NOS2)
pmid:29179999 a(PUBCHEM:440312) decreases p(HGNC:PTGS2)
pmid:29179999 a(PUBCHEM:440312) decreases act(p(HGNC:LOX))
pmid:29179999 a(PUBCHEM:440312) decreases a(CHEBI:"reactive oxygen species")
pmid:29179999 a(PUBCHEM:440312) decreases act(p(FPLX:ERK))
pmid:29179999 a(PUBCHEM:440312) decreases act(p(HGNC:MAPK14))
pmid:29179999 a(PUBCHEM:440312) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:Geniposide) decreases act(p(FPLX:ERK))
pmid:29179999 a(CHEBI:Geniposide) decreases act(p(FPLX:IKB))
pmid:29179999 a(CHEBI:Geniposide) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:Geniposide) decreases p(HGNC:TNF)
pmid:29179999 a(CHEBI:Geniposide) decreases p(HGNC:IL1B)
pmid:29179999 a(CHEBI:Geniposide) decreases a(CHEBI:"amyloid-beta")
pmid:29179999 a(PUBCHEM:102336202) increases path(MESH:"Spatial Memory")
pmid:29179999 a(PUBCHEM:102336202) decreases path(MESH:"Oxidative Stress")
pmid:29179999 a(PUBCHEM:102336202) decreases p(HGNC:NOS2)
pmid:29179999 a(PUBCHEM:102336202) decreases a(CHEBI:nitrotyrosine)
pmid:29179999 a(PUBCHEM:102336202) increases r(HGNC:IL4)
pmid:29179999 a(PUBCHEM:102336202) decreases a(MESH:Cytokines)
pmid:29179999 a(PUBCHEM:102336202) decreases a(CHEBI:"nitric oxide")
pmid:29179999 a(PUBCHEM:102336202) decreases p(HGNC:IL1B)
pmid:29179999 a(PUBCHEM:102336202) decreases p(HGNC:TNF)
pmid:29179999 a(PUBCHEM:102336202) decreases act(p(FPLX:ERK))
pmid:29179999 a(PUBCHEM:102336202) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:"N(5)-ethyl-L-glutamine") increases bp(GO:memory)
pmid:29179999 a(CHEBI:"N(5)-ethyl-L-glutamine") decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:29179999 a(CHEBI:"N(5)-ethyl-L-glutamine") decreases bp(GO:"neuron death")
pmid:29179999 a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:ERK))
pmid:29179999 a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(HGNC:MAPK14))
pmid:29179999 a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(CHEBI:"1,8-cineole") decreases a(CHEBI:"reactive oxygen species")
pmid:29179999 a(CHEBI:"1,8-cineole") decreases a(CHEBI:"nitric oxide")
pmid:29179999 a(CHEBI:"1,8-cineole") decreases p(HGNC:TNF)
pmid:29179999 a(CHEBI:"1,8-cineole") decreases p(HGNC:IL1B)
pmid:29179999 a(CHEBI:"1,8-cineole") decreases p(HGNC:IL6)
pmid:29179999 a(CHEBI:"1,8-cineole") decreases p(HGNC:NOS2)
pmid:29179999 a(CHEBI:"1,8-cineole") decreases p(HGNC:PTGS2)
pmid:29179999 a(CHEBI:"1,8-cineole") decreases p(FPLX:NFkappaB)
pmid:29179999 a(PUBCHEM:442534) increases bp(GO:memory)
pmid:29179999 a(PUBCHEM:442534) decreases a(HBP:"amyloid-beta aggregates")
pmid:29179999 a(PUBCHEM:442534) decreases path(MESH:"Alzheimer Disease")
pmid:29179999 a(PUBCHEM:442534) decreases act(p(FPLX:GSK3))
pmid:29179999 a(PUBCHEM:442534) decreases act(p(FPLX:NFkappaB))
pmid:29179999 a(PUBCHEM:442534) decreases bp(GO:"NLRP3 inflammasome complex assembly")
pmid:29179999 a(PUBCHEM:442534) decreases p(HGNC:TNF)
pmid:29179999 a(PUBCHEM:442534) decreases p(HGNC:IL1B)
pmid:8282104 p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:8282104 p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:8282104 p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:8282104 p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235))
pmid:8282104 p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:8282104 p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:8282104 p(FPLX:GSK3) association a(GO:microtubule)
pmid:8282104 p(FPLX:GSK3) association a(HBP:HBP00006)
pmid:8282104 p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph))))
pmid:8282104 p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 bp(GO:"negative regulation of neuron apoptotic process") association p(FPLX:NFkappaB)
pmid:12428809 bp(GO:"negative regulation of neuron apoptotic process") association sec(p(HGNC:APP))
pmid:27288790 bp(GO:"neuron differentiation") association p(FPLX:NFkappaB)
pmid:24590577 bp(GO:"neuron differentiation") association p(HGNC:CHRM1)
pmid:28884684 bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(kin))
pmid:27288790 bp(GO:"regulation of synaptic plasticity") association p(FPLX:NFkappaB)
pmid:27288790 bp(GO:"regulation of synaptic plasticity") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:30444369 bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2)
pmid:17009926 bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN)
pmid:17009926 bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN)
pmid:24590577 bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1)
pmid:30106381 bp(GO:"regulation of synaptic plasticity") association p(HGNC:DLG4)
pmid:22908190 bp(GO:"regulation of synaptic plasticity") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:22908190 bp(GO:"regulation of synaptic plasticity") association bp(GO:endocytosis)
pmid:22908190 bp(GO:"regulation of synaptic plasticity") association bp(GO:autophagy)
pmid:26631930 bp(GO:"regulation of synaptic plasticity") association p(HGNC:MAPT)
pmid:27288790 p(FPLX:IKB, pmod(Ph)) increases deg(p(FPLX:IKB))
pmid:27288790 p(FPLX:IKB, pmod(Ph)) increases act(p(FPLX:NFkappaB))
pmid:27288790 p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) increases act(p(HGNC:RELA))
pmid:27288790 bp(MESH:"Membrane Fluidity") association a(CHEBI:"reactive oxygen species")
pmid:27288790 bp(GO:"ion transport") association a(CHEBI:"reactive oxygen species")
pmid:17009926 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA7)
pmid:17009926 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA4)
pmid:11230871 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(FPLX:CHRN)
pmid:26837465 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HGNC:ESR1)
pmid:19277525 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(GO:"neurofibrillary tangle")
pmid:22908190 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(GO:"neurofibrillary tangle")
pmid:22299660 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization")
pmid:22299660 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation act(p(FPLX:PPP2))
pmid:29758300 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(MESH:"Alzheimer Disease")
pmid:30145931 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:17403556 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25374103 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24401760 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:25374103 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:29758300 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates")
pmid:21882945 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates")
pmid:25374103 tloc(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) increases a(HBP:"Tau aggregates")
pmid:28877763 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates")
pmid:29758300 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases bp(GO:"microtubule depolymerization")
pmid:30145931 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:Tauopathies)
pmid:22611162 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport")
pmid:22611162 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"synaptic signaling")
pmid:22611162 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"maintenance of synapse structure")
pmid:25374103 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment"))
pmid:28877763 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association act(p(HGNC:SYK))
pmid:26458742 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:HBP00006)
pmid:26458742 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment"))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines"))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(GO:"filamentous actin")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(HBP:Neurodegeneration)
pmid:26631930 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases act(a(GO:synapse))
pmid:23487739 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases a(GO:microtubule)
pmid:19732809 p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation"))
pmid:30106381 bp(GO:autophagy) association p(HGNC:ADNP)
pmid:30106381 bp(GO:autophagy) association p(HGNC:ADNP)
pmid:30106381 bp(GO:autophagy) association a(PUBCHEM:9832404)
pmid:30106381 bp(GO:autophagy) association p(HGNC:MTOR)
pmid:29758300 bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR)
pmid:22020111 bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8))
pmid:29758300 bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 bp(GO:autophagy) association path(MESH:"Alzheimer Disease")
pmid:22908190 bp(GO:autophagy) association path(MESH:"Alzheimer Disease")
pmid:29758300 bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process")
pmid:22908190 bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process")
pmid:29758300 bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolding)))
pmid:18930136 bp(GO:autophagy) regulates deg(p(MESH:Proteins, pmod(HBP:misfolding)))
pmid:29758300 bp(GO:autophagy) increases deg(a(HBP:"protein aggregates"))
pmid:22908190 bp(GO:autophagy) increases deg(a(HBP:"protein aggregates"))
pmid:22908190 bp(GO:autophagy) increases deg(a(HBP:"protein aggregates"))
pmid:22908190 bp(GO:autophagy) increases deg(a(HBP:"protein aggregates"))
pmid:29758300 bp(GO:autophagy) association p(HGNC:MAPT, pmod(Ph))
pmid:29758300 bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:29626319 bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:29758300 bp(GO:autophagy) association a(HBP:"Tau aggregates")
pmid:29758300 bp(GO:autophagy) increases deg(p(HGNC:SNCA))
pmid:18930136 bp(GO:autophagy) increases deg(p(HGNC:SNCA))
pmid:29758300 bp(GO:autophagy) decreases a(CHEBI:lipid)
pmid:29758300 bp(GO:autophagy) increases deg(a(CHEBI:lipid))
pmid:29758300 bp(GO:autophagy) negativeCorrelation a(CHEBI:lipid)
pmid:29758300 bp(GO:autophagy) increases deg(a(CHEBI:carbohydrate))
pmid:29758300 bp(GO:autophagy) increases deg(p(HGNC:MAPT))
pmid:30145931 bp(GO:autophagy) decreases p(HGNC:MAPT)
pmid:24027553 bp(GO:autophagy) association deg(p(HGNC:MAPT))
pmid:23528736 bp(GO:autophagy) increases deg(p(HGNC:MAPT))
pmid:25374103 bp(GO:autophagy) increases deg(p(HGNC:MAPT))
pmid:29626319 bp(GO:autophagy) increases deg(p(HGNC:MAPT))
pmid:29626319 bp(GO:autophagy) increases deg(p(HGNC:MAPT))
pmid:22908190 bp(GO:autophagy) increases deg(a(GO:organelle))
pmid:22908190 bp(GO:autophagy) increases deg(a(GO:organelle))
pmid:22908190 bp(GO:autophagy) increases deg(a(GO:organelle))
pmid:18930136 bp(GO:autophagy) increases tloc(a(GO:organelle), fromLoc(GO:cytoplasm), toLoc(GO:lysosome))
pmid:18930136 bp(GO:autophagy) increases deg(a(GO:organelle))
pmid:18930136 bp(GO:autophagy) increases deg(a(GO:organelle))
pmid:22908190 bp(GO:autophagy) negativeCorrelation bp(GO:"proteasomal protein catabolic process")
pmid:22908190 bp(GO:autophagy) increases deg(p(HBP:"protein aggregates", pmod(Ub)))
pmid:22908190 bp(GO:autophagy) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides")))
pmid:22908190 bp(GO:autophagy) increases deg(a(CHEBI:"amyloid-beta"))
pmid:22908190 bp(GO:autophagy) decreases path(MESH:Tauopathies)
pmid:22908190 bp(GO:autophagy) decreases path(HBP:neurotoxicity)
pmid:22908190 bp(GO:autophagy) increases path(HBP:neurotoxicity)
pmid:30145931 bp(GO:autophagy) decreases path(HBP:neurotoxicity)
pmid:22908190 bp(GO:autophagy) association bp(GO:"regulation of synaptic plasticity")
pmid:23746257 bp(GO:autophagy) increases bp(GO:"protein catabolic process")
pmid:23746257 bp(GO:autophagy) decreases a(MESH:"Protein Aggregates")
pmid:18930136 bp(GO:autophagy) increases bp(GO:"cellular protein catabolic process")
pmid:18930136 bp(GO:autophagy) regulates bp(GO:"amino acid homeostasis")
pmid:18930136 bp(GO:autophagy) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome))
pmid:18930136 bp(GO:autophagy) increases deg(a(MESH:Proteins))
pmid:18930136 bp(GO:autophagy) regulates bp(GO:"metabolic process")
pmid:18930136 bp(GO:autophagy) association bp(GO:"antigen processing and presentation")
pmid:18930136 bp(GO:autophagy) decreases bp(MESH:Microbiota)
pmid:18930136 bp(GO:autophagy) regulates bp(GO:"cell death")
pmid:18930136 bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases")
pmid:18930136 bp(GO:autophagy) negativeCorrelation path(MESH:"Neurodegenerative Diseases")
pmid:18930136 bp(GO:autophagy) increases deg(p(HGNC:SNCA, var("?")))
pmid:18930136 bp(GO:autophagy) increases a(HBP:"alpha-synuclein aggregates")
pmid:18930136 bp(GO:autophagy) increases a(HBP:"alpha-synuclein oligomers")
pmid:18930136 bp(GO:autophagy) regulates bp(GO:"neuron cellular homeostasis")
pmid:18930136 bp(GO:autophagy) decreases path(HBP:Neurodegeneration)
pmid:18930136 bp(GO:autophagy) decreases path(HBP:Neurodegeneration)
pmid:18930136 bp(GO:autophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked")
pmid:18930136 bp(GO:autophagy) increases deg(p(HGNC:APP))
pmid:26195256 bp(GO:autophagy) decreases p(HGNC:APP)
pmid:18930136 bp(GO:autophagy) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:18930136 bp(GO:autophagy) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:28803412 bp(GO:autophagy) increases a(HBP:HBP00093)
pmid:30145931 bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262)))
pmid:30145931 bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 356)))
pmid:30116051 bp(GO:autophagy) negativeCorrelation g(HGNC:PSEN1, var("?"))
pmid:30116051 bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?")))
pmid:24027553 bp(GO:autophagy) association p(HGNC:NPEPPS)
pmid:23702978 bp(GO:autophagy) regulates bp(GO:"apoptotic process")
pmid:23702978 bp(GO:autophagy) regulates complex(GO:"inflammasome complex")
pmid:23702978 bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex"))
pmid:23702978 bp(GO:autophagy) decreases sec(p(HGNC:IL1B))
pmid:27288790 a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:ERK))
pmid:27288790 a(CHEBI:"hydrogen peroxide") increases p(HGNC:MAPT, pmod(Ph))
pmid:14556719 a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein")
pmid:23531502 act(a(CHEBI:"hydrogen peroxide")) positiveCorrelation bp(GO:"neurofibrillary tangle assembly")
pmid:23722080 a(CHEBI:"hydrogen peroxide") increases bp(MESH:"Oxidative Stress")
pmid:23722080 a(CHEBI:"hydrogen peroxide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide"))
pmid:27288790 p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24561250 p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27314526 p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27314526 p(HGNC:IL18) association path(MESH:"Alzheimer Disease")
pmid:27288790 p(HGNC:IL18) increases act(p(FPLX:NFkappaB))
pmid:24561250 p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex")
pmid:24561250 p(HGNC:IL18) increases bp(GO:"inflammatory response")
pmid:27314526 p(HGNC:IL18) positiveCorrelation path(MESH:Dementia)
pmid:27314526 p(HGNC:IL18) increases bp(GO:"microglial cell activation")
pmid:27314526 p(HGNC:IL18) increases bp(GO:"astrocyte activation")
pmid:27314526 p(HGNC:IL18) increases a(CHEBI:"amyloid-beta")
pmid:27314526 p(HGNC:IL18) increases p(HGNC:GSK3B)
pmid:27314526 p(HGNC:IL18) increases p(HGNC:CDK5)
pmid:27288790 p(HGNC:CXCL10) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 p(HGNC:TGFB1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26304819 p(HGNC:TGFB1) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:21718217 p(HGNC:TGFB1) decreases a(MESH:Macrophages)
pmid:27288790 bp(GO:"protein kinase B signaling") increases act(p(FPLX:NFkappaB))
pmid:14556719 bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1)
pmid:14963027 bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1)
pmid:27068745 bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C)
pmid:27288790 bp(GO:"MAPK cascade") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 bp(GO:"MAPK cascade") increases p(FPLX:IKB, pmod(Ph))
pmid:21214928 bp(GO:"MAPK cascade") association a(CHEBI:"amyloid-beta")
pmid:19293145 bp(GO:"MAPK cascade") increases a(CHEBI:"amyloid-beta")
pmid:19126755 bp(GO:"MAPK cascade") increases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 bp(GO:"MAPK cascade") increases act(p(HGNC:BAD))
pmid:19293145 bp(GO:"MAPK cascade") increases act(p(HGNC:MYC))
pmid:19293145 bp(GO:"MAPK cascade") increases act(p(HGNC:MYC))
pmid:19293145 bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB))
pmid:19293145 bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1))
pmid:24590577 bp(GO:"MAPK cascade") increases p(HGNC:BACE1)
pmid:27288790 bp(GO:"ERK1 and ERK2 cascade") increases act(p(FPLX:NFkappaB))
pmid:21214928 bp(GO:"ERK1 and ERK2 cascade") association a(CHEBI:"amyloid-beta")
pmid:19126755 bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine))
pmid:19293145 bp(GO:"ERK1 and ERK2 cascade") increases bp(GO:"apoptotic process")
pmid:24590577 bp(GO:"ERK1 and ERK2 cascade") regulates act(p(HGNC:ADAM10))
pmid:24590577 bp(GO:"ERK1 and ERK2 cascade") regulates bp(HBP:"APP processing")
pmid:27594586 bp(GO:"ERK1 and ERK2 cascade") regulates p(HGNC:MMP9)
pmid:27288790 a(CHEBI:"SB-239063") decreases act(p(HGNC:MAPK14))
pmid:27288790 a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") decreases p(FPLX:JNK)
pmid:27288790 a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") increases act(p(HGNC:MAPK14))
pmid:27288790 a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:27288790 a(CHEBI:"advanced glycation end-product") decreases bp(GO:memory)
pmid:27288790 a(CHEBI:"advanced glycation end-product") increases bp(GO:"cellular protein catabolic process")
pmid:27288790 a(CHEBI:"advanced glycation end-product") decreases bp(GO:"long-term synaptic potentiation")
pmid:25681682 a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER))
pmid:24183963 a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER))
pmid:24183963 a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(Ph))
pmid:26095350 a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 214))
pmid:26095350 a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:22798221 a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Gsk3b), ma(kin))
pmid:22798221 a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Mapk14), ma(kin))
pmid:8063802 a(CHEBI:"advanced glycation end-product") decreases act(p(HGNC:MAPT))
pmid:8063802 a(CHEBI:"advanced glycation end-product") increases bp(GO:"neurofibrillary tangle assembly")
pmid:18930136 bp(GO:"cellular protein catabolic process") regulates bp(GO:"cellular homeostasis")
pmid:18930136 bp(GO:"cellular protein catabolic process") negativeCorrelation path(MESH:Neoplasms)
pmid:18930136 bp(GO:"cellular protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration)
pmid:25036637 bp(GO:"cellular protein catabolic process") association p(HGNC:DCP1A)
pmid:25036637 bp(GO:"cellular protein catabolic process") association p(HGNC:EDC3)
pmid:25036637 bp(GO:"cellular protein catabolic process") association p(HGNC:DDX6)
pmid:27671637 bp(GO:"cellular protein catabolic process") negativeCorrelation composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt))
pmid:27288790 a(CHEBI:pentosidine) isA a(CHEBI:"advanced glycation end-product")
pmid:27288790 a(CHEBI:pentosidine) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 a(HBP:GLAP) isA a(CHEBI:"advanced glycation end-product")
pmid:27288790 a(HBP:GLAP) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases p(HGNC:BACE1)
pmid:27288790 complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB))
pmid:27288790 act(p(HGNC:AGER)) increases bp(GO:"MAPK cascade")
pmid:26195256 p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:18494933 act(p(HGNC:AGER)) positiveCorrelation p(FPLX:JNK)
pmid:25681682 p(HGNC:AGER) negativeCorrelation bp(GO:aging)
pmid:25681682 p(HGNC:AGER) negativeCorrelation bp(MESH:"Body Mass Index")
pmid:24183963 act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(kin))
pmid:18494933 act(p(HGNC:AGER)) increases p(HGNC:MAPK8, pmod(Ph))
pmid:27288790 complex(a(HBP:GLAP), p(HGNC:AGER)) increases p(HGNC:BACE1)
pmid:27288790 complex(a(HBP:GLAP), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB))
pmid:27288790 p(HGNC:GSK3B) increases p(HGNC:BACE1)
pmid:30444369 act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph))
pmid:12428809 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph))
pmid:29758300 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph))
pmid:21882945 act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:29191965 p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:29311797 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))
pmid:12551948 act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph))
pmid:24183963 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))
pmid:18494933 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))
pmid:29121589 act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:10998059 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))
pmid:27314526 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph))
pmid:22122372 p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 654))
pmid:22122372 p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 668))
pmid:22122372 p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Ser, 665))
DOI:10.4172/2168-975X.1000126 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:25331948 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:14612456 p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:19459590 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:29844403 act(p(HGNC:GSK3B)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
DOI:10.4172/2168-975X.1000126 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:25331948 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:14612456 p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:19459590 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
DOI:10.4172/2168-975X.1000126 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
DOI:10.4172/2168-975X.1000126 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:25331948 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:14612456 p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:21734277 act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:24653673 p(HGNC:GSK3B) association path(MESH:"Alzheimer Disease")
pmid:24653673 act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton")
pmid:24653673 act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"neurofilament cytoskeleton")
pmid:24653673 act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:APP, pmod(Ph))
pmid:24653673 act(p(HGNC:GSK3B)) negativeCorrelation bp(HBP:"APP processing")
pmid:24653673 act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:neurogenesis)
pmid:24653673 act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity")
pmid:24653673 act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"apoptotic process")
pmid:24653673 act(p(HGNC:GSK3B)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 act(p(HGNC:GSK3B)) increases p(FPLX:PPP2, pmod(Ph, Tyr, 307))
pmid:24653673 act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:24653673 act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CB, pmod(Me, Leu, 309))
pmid:24653673 act(p(HGNC:GSK3B)) decreases act(p(HGNC:LCMT1))
pmid:24653673 act(p(HGNC:GSK3B)) increases act(p(HGNC:PPME1))
pmid:24653673 act(p(HGNC:GSK3B)) increases p(HGNC:SET)
pmid:12428809 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:18494933 act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:12428809 p(HGNC:GSK3B) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT))
pmid:12428809 p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
pmid:12428809 p(HGNC:GSK3B) increases a(MESH:Axons)
pmid:12428809 p(HGNC:GSK3B) association bp(GO:"axonal transport")
pmid:21882945 p(HGNC:GSK3B) increases act(p(HGNC:MARK2))
pmid:30640040 p(HGNC:GSK3B) association a(PUBCHEM:71295844)
pmid:29191965 p(HGNC:GSK3B) association path(MESH:Tauopathies)
pmid:11812770 p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, frag("1_244"))
pmid:11812770 p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT))
pmid:14612456 p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:21734277 act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:18494933 act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"Wnt signaling pathway")
pmid:12551948 p(HGNC:GSK3B) association p(HGNC:YWHAZ)
pmid:12551948 p(HGNC:GSK3B) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ))
pmid:29121589 p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(Ph))
pmid:29121589 p(HGNC:GSK3B) decreases p(HGNC:NFE2L2)
pmid:24355211 p(HGNC:GSK3B) decreases p(HGNC:NFE2L2)
pmid:29121589 act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:DPYSL2, pmod(Ph))
pmid:7514173 act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:CREB, pmod(Ph))
pmid:7514173 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MBP, pmod(Ph))
pmid:7514173 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSN3, pmod(Ph))
pmid:7514173 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:PPP1R2, pmod(Ph))
pmid:7514173 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSNK2B, pmod(Ph))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:19459590 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:21734277 act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 217))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:17078951 act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 212))
pmid:9089387 act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:PDH, pmod(Ph))
pmid:9089387 p(HGNC:GSK3B) isA p(ECCODE:"2.7.11.26")
pmid:26501932 p(HGNC:GSK3B) partOf a(HBP:"GVD bodies")
pmid:25331948 act(p(HGNC:GSK3B), ma(kin)) increases a(HBP:"Tau epitope, PHF1")
pmid:25331948 act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation act(p(HGNC:SYK))
pmid:28176663 act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I")
pmid:28176663 act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II")
pmid:28176663 act(p(HGNC:GSK3B), ma(kin)) negativeCorrelation a(HBP:"Braak_Stage V")
pmid:19459590 act(p(HGNC:GSK3B), ma(kin)) increases p(HBP:"Tau epitope, AT8")
pmid:24355211 p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress")
pmid:24355211 p(HGNC:GSK3B) negativeCorrelation bp(GO:learning)
pmid:24355211 p(HGNC:GSK3B) negativeCorrelation bp(GO:memory)
pmid:24355211 act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231))
pmid:24355211 act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235))
pmid:25546293 act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 33))
pmid:25546293 act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 37))
pmid:25546293 act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Thr, 41))
pmid:27288790 p(HGNC:GSK3A) causesNoChange p(HGNC:BACE1)
pmid:30640040 p(HGNC:GSK3A) association a(PUBCHEM:71295844)
pmid:22817713 p(HGNC:GSK3A) decreases bp(GO:"anterograde axonal protein transport")
pmid:27288790 composite(p(HGNC:GSK3B), p(HGNC:RELA)) increases r(HGNC:BACE1)
pmid:27288790 p(HGNC:UCHL1) decreases p(HGNC:BACE1)
pmid:27288790 act(p(HGNC:UCHL1)) decreases p(HGNC:BACE1)
pmid:14556719 p(HGNC:UCHL1) decreases bp(GO:"protein ubiquitination")
pmid:14556719 p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(Ub))
pmid:14556719 p(HGNC:UCHL1) decreases path(MESH:"Deglutition Disorders")
pmid:14556719 p(HGNC:UCHL1) positiveCorrelation a(MESH:"Solitary Nucleus")
pmid:14556719 p(HGNC:UCHL1) positiveCorrelation a(MESH:"Area Postrema")
pmid:22908190 p(HGNC:UCHL1) association path(MESH:"Parkinson Disease")
pmid:22908190 p(HGNC:UCHL1) association path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:UCHL1) increases act(a(GO:synapse))
pmid:22908190 p(HGNC:UCHL1) increases bp(GO:memory)
pmid:27288790 a(MESH:Lipopolysaccharides) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:27288790 a(MESH:Lipopolysaccharides) increases p(HGNC:TNF)
pmid:27288790 a(MESH:Lipopolysaccharides) increases sec(p(HGNC:TNF))
pmid:27288790 a(MESH:Lipopolysaccharides) increases p(HGNC:IL1B)
pmid:27288790 a(MESH:Lipopolysaccharides) increases sec(p(HGNC:IL1B))
pmid:27288790 m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:ALOX15)
pmid:27288790 m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:VDR)
pmid:25001178 m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5R1))
pmid:25001178 m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5), ma(kin))
pmid:25001178 m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK3), ma(kin))
pmid:25001178 m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK1), ma(kin))
pmid:25001178 m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:PPP1CA))
pmid:25001178 m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:DUSP6))
pmid:25001178 m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:BCL2L2))
pmid:27288790 m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:ALOX15)
pmid:27288790 m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:VDR)
pmid:27288790 m(MIRBASE:"hsa-mir-146a") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 m(MIRBASE:"hsa-mir-146a") association r(HGNC:IRAK1)
pmid:27288790 m(MIRBASE:"hsa-mir-146a") association bp(GO:"immune response")
pmid:27288790 m(MIRBASE:"hsa-mir-146a") increases path(HP:Neurodegeneration)
pmid:27288790 m(MIRBASE:"hsa-mir-155") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27288790 m(MIRBASE:"hsa-mir-155") positiveCorrelation path(MESH:"Multiple Sclerosis")
pmid:27288790 r(HGNC:IRAK1) association m(MIRBASE:"hsa-mir-146a")
pmid:27288790 path(MESH:"Multiple Sclerosis") positiveCorrelation m(MIRBASE:"hsa-mir-155")
pmid:27288790 r(HGNC:"BACE1-AS") regulates r(HGNC:BACE1)
pmid:27288790 r(HGNC:"BACE1-AS") decreases deg(r(HGNC:BACE1))
pmid:27288790 r(HGNC:"BACE1-AS") regulates p(HGNC:BACE1)
pmid:27288790 r(HGNC:"BACE1-AS") increases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:27288790 a(CHEBI:"(+)-Tetrandrine") decreases act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:"(+)-Tetrandrine") decreases p(HGNC:NOS2)
pmid:27288790 a(CHEBI:"(+)-Tetrandrine") decreases p(HGNC:PTGS2)
pmid:27288790 a(MESH:Morphine) decreases act(p(FPLX:NFkappaB))
pmid:27288790 a(MESH:Morphine) increases p(FPLX:IKB)
pmid:27288790 a(PUBCHEM:439378) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:27288790 a(PUBCHEM:439378) decreases p(FPLX:ERK)
pmid:27288790 a(PUBCHEM:439378) decreases p(HGNC:MAPK14)
pmid:27288790 a(PUBCHEM:439378) decreases p(FPLX:NFkappaB)
pmid:27288790 a(PUBCHEM:3968) decreases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42))
pmid:27288790 a(PUBCHEM:3968) decreases act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:melatonin) decreases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42))
pmid:27288790 a(CHEBI:melatonin) decreases act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:naproxen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal")
pmid:27288790 a(CHEBI:naproxen) decreases r(HGNC:BACE1)
pmid:27288790 a(CHEBI:naproxen) decreases a(CHEBI:"amyloid-beta")
pmid:27288790 a(CHEBI:hydroxytyrosol) decreases act(p(FPLX:NFkappaB))
pmid:27288790 a(CHEBI:nicorandil) decreases bp(GO:"apoptotic process")
pmid:27288790 a(CHEBI:nicorandil) decreases path(MESH:"Oxidative Stress")
pmid:27288790 a(CHEBI:nicorandil) decreases p(HBP:APP695)
pmid:27288790 a(CHEBI:nicorandil) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:27288790 a(PUBCHEM:6440944) decreases act(p(FPLX:ERK))
pmid:27288790 a(PUBCHEM:6440944) decreases p(HGNC:NFKBIA, pmod(Ph))
pmid:27288790 a(PUBCHEM:6440944) decreases p(FPLX:NFkappaB, pmod(Ph))
pmid:27288790 a(PUBCHEM:6440944) decreases act(p(FPLX:NFkappaB))
pmid:27288790 a(PUBCHEM:6440944) decreases p(HGNC:MAPT, pmod(Ph))
pmid:27288790 a(PUBCHEM:6440944) decreases p(HGNC:APP)
pmid:27288790 a(PUBCHEM:6440944) decreases a(CHEBI:"amyloid-beta")
pmid:27288790 a(PUBCHEM:6440944) decreases sec(a(CHEBI:"amyloid-beta"))
pmid:25652642 complex(a(GO:"NF-kappaB complex"), p(HGNC:NFKB1), p(HGNC:RELA)) increases act(complex(GO:"NF-kappaB p50/p65 complex"))
pmid:25652642 bp(GO:"membrane depolarization") increases act(complex(GO:"NF-kappaB complex"))
pmid:17009926 bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex"))
pmid:26813123 bp(GO:"membrane depolarization") regulates act(p(HGNC:CHAT))
pmid:26813123 bp(GO:"membrane depolarization") increases tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft"))
pmid:26813123 bp(GO:"membrane depolarization") increases complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7))
pmid:25652642 bp(GO:"synaptic transmission, glutamatergic") increases act(complex(GO:"NF-kappaB complex"))
pmid:24511233 bp(GO:"synaptic transmission, glutamatergic") association path(MESH:Schizophrenia)
pmid:26813123 bp(GO:"synaptic transmission, glutamatergic") association bp(GO:cognition)
pmid:26813123 bp(GO:"synaptic transmission, glutamatergic") association bp(HBP:Neurodegeneration)
pmid:30106381 bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation p(HGNC:ADNP)
pmid:30106381 bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation a(PUBCHEM:9832404)
pmid:25652642 bp(GO:"calmodulin dependent kinase signaling pathway") increases act(complex(GO:"NF-kappaB complex"))
pmid:25652642 bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex"))
pmid:19126755 bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:22040696 bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death")
pmid:22040696 bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN)
pmid:25652642 a(MESH:"I-kappa B Proteins") decreases act(complex(GO:"NF-kappaB complex"))
pmid:25652642 a(GO:"neurofibrillary tangle") positiveCorrelation act(complex(GO:"NF-kappaB complex"))
pmid:29196815 a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28420982 a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22817713 a(GO:"neurofibrillary tangle") association path(MESH:"Alzheimer Disease")
pmid:24653673 a(GO:"neurofibrillary tangle") association p(FPLX:PPP2, pmod(Me, Tyr, 307))
pmid:29758300 a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?"))
pmid:22908190 a(GO:"neurofibrillary tangle") association a(HBP:"paired helical filaments")
pmid:22908190 a(GO:"neurofibrillary tangle") association a(MESH:Ubiquitin)
pmid:22908190 a(GO:"neurofibrillary tangle") negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:22908190 a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:UCHL1, pmod(GO:"protein oxidation"))
pmid:22908190 a(GO:"neurofibrillary tangle") association bp(GO:"protein K63-linked ubiquitination")
pmid:22908190 a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:18930136 a(GO:"neurofibrillary tangle") association p(HGNC:SQSTM1)
pmid:27671637 a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:30126037 a(GO:"neurofibrillary tangle") decreases bp(GO:cognition)
pmid:30126037 a(GO:"neurofibrillary tangle") increases bp(GO:"cell death")
pmid:30126037 a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death")
pmid:30126037 a(GO:"neurofibrillary tangle") positiveCorrelation p(MGI:Cdkn2a)
pmid:30126037 a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a))
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a)
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a)
pmid:30126037 a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence")
pmid:30126037 a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival")
pmid:30126037 a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response")
pmid:30126037 a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle")
pmid:30126037 a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process")
pmid:30126037 a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis)
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1)
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG)
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(HGNC:TNF)
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4)
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B)
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1)
pmid:30126037 a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng))
pmid:30126037 a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf))
pmid:30126037 a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b))
pmid:30126037 a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1))
pmid:30126037 a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1))
pmid:30126037 a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2))
pmid:30126037 a(GO:"neurofibrillary tangle") association p(HGNC:CDKN2A)
pmid:30126037 a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDKN2A)
pmid:30126037 a(GO:"neurofibrillary tangle") increases p(HGNC:CDKN2A)
pmid:30126037 a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport")
pmid:30126037 a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Right Ventricular")
pmid:30126037 a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Left Ventricular")
pmid:30126037 a(GO:"neurofibrillary tangle") association path(HP:"Brain atrophy")
pmid:26751493 a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP)
pmid:26751493 a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25)
pmid:26751493 a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin)
pmid:23531502 a(GO:"neurofibrillary tangle") positiveCorrelation act(a(CHEBI:acrolein))
pmid:12578227 a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1)
pmid:12578227 a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2)
pmid:9099822 a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNC:TGM2))
pmid:11089576 a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13"))
pmid:11738469 a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13"))
pmid:8985134 a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13"))
pmid:18239272 a(GO:"neurofibrillary tangle") association p(HBP:"Tau epitope, AT8")
pmid:26751493 a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain")
pmid:26118667 a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"CDK5R1 p25")
pmid:22002427 a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:22002427 a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205))
pmid:25652642 path(MESH:"Plaque, Amyloid") positiveCorrelation act(complex(GO:"NF-kappaB complex"))
pmid:25652642 path(MESH:"Plaque, Amyloid") association complex(GO:"NF-kappaB complex")
pmid:25652642 path(MESH:"Plaque, Amyloid") association a(MESH:"HLA-DR Antigens")
pmid:29196815 path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19126755 path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease")
pmid:19293145 path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease")
pmid:24590577 path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease")
pmid:25514383 path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22817713 path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 path(MESH:"Plaque, Amyloid") association p(HGNC:CHRNA7)
pmid:19293145 path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4)
pmid:19293145 path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7)
pmid:24511233 path(MESH:"Plaque, Amyloid") association a(HBP:"amyloid-beta aggregates")
pmid:24511233 path(MESH:"Plaque, Amyloid") increases bp(HBP:neuroinflammation)
pmid:24511233 path(MESH:"Plaque, Amyloid") increases bp(GO:"cell death")
pmid:24590577 path(MESH:"Plaque, Amyloid") association bp(GO:"synaptic transmission, cholinergic")
pmid:25514383 path(MESH:"Plaque, Amyloid") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7))
pmid:29758300 path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Parkinson Disease")
pmid:14556719 path(MESH:"Plaque, Amyloid") association a(MESH:"Amyloid beta-Peptides")
pmid:24027553 path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAP1LC3A)
pmid:28420982 path(MESH:"Plaque, Amyloid") association a(MESH:Exosomes)
pmid:23531502 path(MESH:"Plaque, Amyloid") positiveCorrelation act(a(CHEBI:acrolein))
pmid:18562203 path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
pmid:26400044 path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph)))
pmid:18239272 path(MESH:"Plaque, Amyloid") association p(HBP:"Tau epitope, AT8")
pmid:28877763 path(MESH:"Plaque, Amyloid") positiveCorrelation p(MGI:Syk, pmod(Ph))
pmid:28877763 path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(Ph))
pmid:24401760 path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:ITPKB)
pmid:24401760 path(MESH:"Plaque, Amyloid") partOf a(HBP:"dystrophic neurite")
pmid:25652642 act(p(HGNC:APOE)) association complex(GO:"NF-kappaB complex")
pmid:19293145 p(HGNC:APOE) association bp(GO:"lipid metabolic process")
pmid:19293145 p(HGNC:APOE) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:21718217 p(HGNC:APOE) increases a(CHEBI:"high-density lipoprotein")
pmid:21718217 p(HGNC:APOE) increases deg(a(CHEBI:"amyloid-beta"))
pmid:21718217 act(p(HGNC:APOE)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:26195256 p(HGNC:APOE) regulates a(CHEBI:"amyloid-beta")
pmid:26195256 p(HGNC:APOE) decreases act(a(CHEBI:"amyloid-beta"))
pmid:26195256 p(HGNC:APOE) regulates a(CHEBI:"amyloid-beta")
pmid:30106381 p(HGNC:APOE) association a(PUBCHEM:9832404)
pmid:30106381 p(HGNC:APOE) increases path(MESH:"Alzheimer Disease")
pmid:25652642 composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:TNF))
pmid:25652642 composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:NGF))
pmid:25652642 composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:BDNF))
pmid:25652642 a(MESH:"amyloid beta-protein (25-35)") increases act(complex(GO:"NF-kappaB complex"))
pmid:19126755 act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade")
pmid:19126755 act(p(HGNC:NGF)) increases complex(p(HGNC:JUN), p(HGNC:SP1))
pmid:19126755 p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:18986241 p(HGNC:NGF) isA a(MESH:D009414)
pmid:18986241 act(p(HGNC:NGF)) increases bp(GO:"GO:0000165")
pmid:18986241 p(HGNC:NGF) causesNoChange path(MESH:D003929)
pmid:18986241 p(HGNC:NGF) causesNoChange path(MESH:D016263)
pmid:18986241 p(HGNC:NGF) causesNoChange path(MESH:D000544)
pmid:18986241 p(HGNC:NGF) association bp(GO:"GO:0060384")
pmid:18986241 p(HGNC:NGF) association bp(GO:"GO:0007269")
pmid:18986241 p(HGNC:NGF) association bp(GO:"GO:0048485")
pmid:18986241 p(HGNC:NGF) association path(MESH:D002100)
pmid:18986241 p(HGNC:NGF) association path(MESH:D006930)
pmid:18986241 p(HGNC:NGF) decreases path(MESH:D060825)
pmid:24686445 p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph))
pmid:24686445 p(HGNC:NGF) increases act(p(HGNC:KAT2B))
pmid:25652642 p(HGNC:GRM5) increases complex(a(GO:"NF-kappaB complex"), p(HGNC:REL))
pmid:25652642 p(HGNC:GRM5) increases act(p(HGNC:SOD2))
pmid:25652642 p(HGNC:GRM5) increases act(p(HGNC:BCL2L1))
pmid:24653673 p(HGNC:GRM5) association path(MESH:"Alzheimer Disease")
pmid:25652642 complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) decreases act(a(CHEBI:"amyloid-beta"))
pmid:14556719 bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37)
pmid:23746257 bp(GO:"cell death") negativeCorrelation bp(HBP:Proteostasis)
pmid:18930136 bp(GO:"cell death") negativeCorrelation a(GO:aggresome)
pmid:24561250 bp(GO:"cell death") increases sec(a(CHEBI:ATP))
pmid:25652642 complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT))
pmid:26813123 act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention)
pmid:26813123 a(MESH:"Cholinergic Neurons") increases path(MESH:Attention)
pmid:26813123 a(MESH:"Cholinergic Neurons") positiveCorrelation bp(GO:memory)
pmid:26813123 a(MESH:"Cholinergic Neurons") increases bp(GO:memory)
pmid:26813123 a(MESH:"Cholinergic Neurons") increases bp(GO:"circadian sleep/wake cycle, REM sleep")
pmid:26813123 a(MESH:"Cholinergic Neurons") increases a(CHEBI:acetylcholine)
pmid:26813123 a(MESH:"Cholinergic Neurons") increases a(CHEBI:choline)
pmid:26813123 a(MESH:"Cholinergic Neurons") increases tloc(p(HGNC:ACHE), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft"))
pmid:26813123 a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic")
pmid:26813123 a(MESH:"Cholinergic Neurons") decreases path(MESH:Apathy)
pmid:26813123 a(MESH:"Cholinergic Neurons") decreases path(MESH:Depression)
pmid:26813123 a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26813123 a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Parkinson Disease")
pmid:26813123 a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome")
pmid:26813123 a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:26813123 a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:26813123 a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Olivopontocerebellar Atrophies")
pmid:26813123 a(MESH:"Cholinergic Neurons") association act(p(HGNC:CHRM1))
pmid:28901280 a(MESH:"Cholinergic Neurons") increases a(MESH:Acetylcholine)
pmid:19293145 tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) increases bp(GO:"apoptotic process")
pmid:25652642 bp(GO:"positive regulation of advanced glycation end-product receptor activity") increases act(a(MESH:Microglia))
pmid:25652642 bp(GO:"peroxisome proliferator activated receptor signaling pathway") increases act(a(MESH:Microglia))
pmid:25652642 p(MESH:"I-kappa B Proteins", pmod(Ph)) increases act(a(MESH:Microglia))
pmid:25652642 a(MESH:"HLA-DR Antigens") association path(MESH:"Plaque, Amyloid")
pmid:25652642 a(MESH:"HLA-DR Antigens") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 m(HGNC:"MIR9-1") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 m(HGNC:MIR34A) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 m(HGNC:MIR125B1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 m(HGNC:MIR125B1) positiveCorrelation p(HGNC:GFAP)
pmid:25652642 m(HGNC:MIR125B1) positiveCorrelation p(HGNC:VIM)
pmid:25652642 m(HGNC:MIR125B1) positiveCorrelation p(HGNC:CDKN2A)
pmid:25652642 m(HGNC:MIR146A) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 m(HGNC:MIR155) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 m(HGNC:MIR339) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25652642 p(HGNC:VIM) positiveCorrelation m(HGNC:MIR125B1)
pmid:25652642 p(HGNC:CDKN2A) positiveCorrelation m(HGNC:MIR125B1)
pmid:30126037 p(HGNC:CDKN2A) association a(GO:"neurofibrillary tangle")
pmid:30126037 p(HGNC:CDKN2A) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:30126037 p(HGNC:CDKN2A) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:30126037 p(HGNC:CDKN2A) association bp(HP:Neurodegeneration)
pmid:30126037 p(HGNC:CDKN2A) association path(MESH:"Cognitive Dysfunction")
pmid:30444369 a(CHEBI:tacrine) increases bp(GO:cognition)
pmid:30444369 a(CHEBI:tacrine) decreases act(p(FPLX:Cholinesterase))
pmid:19293145 a(CHEBI:tacrine) increases p(HGNC:BCL2)
pmid:19293145 act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE)
pmid:24511233 a(CHEBI:tacrine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")
pmid:11230871 a(CHEBI:tacrine) increases act(p(HGNC:ACHE))
pmid:11230871 a(CHEBI:tacrine) increases act(p(HGNC:ACHE))
pmid:11230871 a(CHEBI:tacrine) increases p(FPLX:CHRN)
pmid:30444369 a(CHEBI:donepezil) increases bp(GO:cognition)
pmid:26813123 a(CHEBI:donepezil) increases bp(GO:cognition)
pmid:30444369 a(CHEBI:donepezil) decreases act(p(FPLX:Cholinesterase))
pmid:19126755 a(CHEBI:donepezil) decreases p(HGNC:ACHE)
pmid:11230871 a(CHEBI:donepezil) increases act(p(HGNC:ACHE))
pmid:19293145 a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor")
pmid:19293145 a(CHEBI:donepezil) decreases path(MESH:"Alzheimer Disease")
pmid:19293145 a(CHEBI:donepezil) decreases path(HBP:neurotoxicity)
pmid:19293145 a(CHEBI:donepezil) decreases path(HBP:neurotoxicity)
pmid:19293145 a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 a(CHEBI:donepezil) increases p(HGNC:CHRNA4)
pmid:19293145 a(CHEBI:donepezil) increases p(HGNC:CHRNA7)
pmid:19293145 a(CHEBI:donepezil) increases bp(MESH:Neuroprotection)
pmid:19293145 a(CHEBI:donepezil) increases p(HGNC:BCL2)
pmid:24511233 a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")
pmid:18986241 a(CHEBI:donepezil) increases act(a(MESH:D005625))
pmid:29626319 a(CHEBI:donepezil) increases p(HGNC:ABCB1)
pmid:29626319 a(CHEBI:donepezil) increases p(HGNC:LRP1)
pmid:29626319 a(CHEBI:donepezil) decreases a(CHEBI:"amyloid-beta")
pmid:30444369 a(CHEBI:rivastigmine) increases bp(GO:cognition)
pmid:30444369 a(CHEBI:rivastigmine) decreases act(p(FPLX:Cholinesterase))
pmid:19126755 a(CHEBI:rivastigmine) decreases p(HGNC:ACHE)
pmid:11230871 a(CHEBI:rivastigmine) increases act(p(HGNC:ACHE))
pmid:19293145 a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor")
pmid:19293145 a(CHEBI:rivastigmine) decreases path(MESH:"Alzheimer Disease")
pmid:26813123 a(CHEBI:rivastigmine) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 a(CHEBI:rivastigmine) decreases path(HBP:neurotoxicity)
pmid:19293145 a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:24511233 a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")
pmid:29626319 a(CHEBI:rivastigmine) increases p(HGNC:ABCB1)
pmid:29626319 a(CHEBI:rivastigmine) increases p(HGNC:LRP1)
pmid:29626319 a(CHEBI:rivastigmine) decreases a(CHEBI:"amyloid-beta")
pmid:30444369 a(CHEBI:memantine) increases bp(GO:cognition)
pmid:30444369 a(CHEBI:memantine) decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
pmid:19293145 a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist")
pmid:19293145 a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease")
pmid:23722080 a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease")
pmid:26813123 a(CHEBI:memantine) decreases a(HBP:Excitotoxicity)
pmid:16273023 a(CHEBI:memantine) decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
pmid:16273023 a(CHEBI:memantine) causesNoChange bp(MESH:D009435)
pmid:23722080 a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 262))
pmid:23722080 a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 404))
pmid:23722080 a(CHEBI:memantine) increases bp(GO:"cellular metabolic process")
pmid:19126755 act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide)
pmid:24511233 p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity")
pmid:24511233 p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association bp(GO:cognition)
pmid:16273023 act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774)
pmid:30444369 g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:29196815 g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:26195256 g(HGNC:APP, var("?")) association path(MESH:"Alzheimer Disease")
pmid:30444369 g(HGNC:APP, var("?")) increases p(HGNC:MAPT)
pmid:30116051 g(HGNC:APP, var("?")) decreases act(a(GO:endosome))
pmid:30116051 g(HGNC:APP, var("?")) decreases act(a(GO:lysosome))
pmid:30116051 g(HGNC:APP, var("?")) increases a(HBP:HBP00081)
pmid:30444369 g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease")
pmid:29758300 g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease")
pmid:22908190 g(HBP:"APOE e4") association path(MESH:"Alzheimer Disease")
pmid:30444369 g(HBP:"APOE e4") decreases deg(p(HGNC:APP))
pmid:29758300 g(HBP:"APOE e4") increases bp(GO:"cholesterol metabolic process")
pmid:29758300 g(HBP:"APOE e4") regulates deg(a(CHEBI:"amyloid-beta"))
pmid:22908190 g(HBP:"APOE e4") increases act(a(CHEBI:"amyloid-beta"))
pmid:22908190 g(HBP:"APOE e4") regulates bp(GO:"cholesterol transport")
pmid:22908190 g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
pmid:22908190 g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
pmid:22908190 g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
pmid:22908190 g(HBP:"APOE e4") positiveCorrelation bp(GO:endocytosis)
pmid:22908190 g(HBP:"APOE e4") increases a(GO:endosome)
pmid:22908190 g(HBP:"APOE e4") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome))
pmid:22908190 g(HBP:"APOE e4") increases path(HBP:Neurodegeneration)
pmid:22908190 g(HBP:"APOE e4") increases bp(GO:"apoptotic process")
pmid:30444369 g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:29196815 g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:30116051 g(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26195256 g(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease")
pmid:30116051 g(HGNC:PSEN1, var("?")) negativeCorrelation act(complex(GO:"lysosomal proton-transporting V-type ATPase complex"))
pmid:30116051 g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:autophagy)
pmid:30116051 g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy)
pmid:30444369 g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:29196815 g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:26195256 g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease")
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A))
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A))
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4")
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4")
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4")
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol")
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol")
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation p(HGNC:APP)
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:cholesterol)
pmid:22908190 p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation bp(GO:endocytosis)
pmid:29758300 path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease")
pmid:29758300 path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease")
pmid:29758300 path(HBP:"mitochondrial dysfunction") decreases a(CHEBI:ATP)
pmid:29758300 path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species")
pmid:29758300 path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"amyloid-beta")
pmid:29758300 path(HBP:"mitochondrial dysfunction") increases p(HGNC:MAPT)
pmid:29758300 path(HBP:"mitochondrial dysfunction") increases bp(GO:mitophagy)
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10))
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases path(MESH:"Alzheimer Disease")
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"response to oxidative stress")
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species")
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species")
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic DNA fragmentation")
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"neuron death")
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:learning)
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(FPLX:COX))
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:"regulation of mitochondrial membrane potential")
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases a(CHEBI:ATP)
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases act(p(HGNC:CASP3))
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic process")
pmid:30444369 complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10))
pmid:30444369 p(HGNC:HSD17B10) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30444369 act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:440326)), products(a(PUBCHEM:193425)))
pmid:30444369 act(p(HGNC:HSD17B10)) increases rxn(reactants(a(CHEBI:"NAD(+)"), a(PUBCHEM:9543037)), products(a(CHEBI:"3-oxo-fatty acyl-CoA(4-)"), a(CHEBI:NADH), a(PUBCHEM:1038)))
pmid:30444369 act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:15818)), products(a(PUBCHEM:10635)))
pmid:30444369 act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:5757)), products(a(PUBCHEM:5870)))
pmid:30444369 act(p(HGNC:HSD17B10)) association p(FPLX:GABR)
pmid:30116051 a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1))
pmid:30116051 a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1))
pmid:30444369 a(PUBCHEM:5757) decreases a(HBP:"amyloid-beta aggregates")
pmid:30444369 a(PUBCHEM:5757) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:30444369 a(PUBCHEM:5757) decreases act(p(HGNC:GSK3B))
pmid:30444369 a(PUBCHEM:5757) increases p(HGNC:GSK3B, pmod(Ph))
pmid:30444369 a(PUBCHEM:5757) increases p(HGNC:BCL2)
pmid:30444369 a(PUBCHEM:5757) increases p(HGNC:BCL2L1)
pmid:30444369 a(PUBCHEM:5757) decreases p(HGNC:BCL2L11)
pmid:30444369 a(PUBCHEM:5757) increases p(HGNC:SOD2)
pmid:30444369 a(PUBCHEM:5757) increases p(FPLX:GPX)
pmid:30444369 p(FPLX:GABR) association act(p(HGNC:HSD17B10))
pmid:30444369 a(CHEBI:"methylene blue") decreases complex(p(HGNC:APP), p(HGNC:HSD17B10))
pmid:30444369 a(CHEBI:"methylene blue") decreases path(HBP:"mitochondrial dysfunction")
pmid:30444369 a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10)
pmid:30444369 a(CHEBI:"methylene blue") decreases a(HBP:"amyloid-beta aggregates")
pmid:29758300 a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(HBP:misfolding))
pmid:29758300 a(CHEBI:"methylene blue") increases bp(GO:macroautophagy)
pmid:29758300 a(CHEBI:"methylene blue") increases p(HGNC:BECN1)
pmid:30116051 a(CHEBI:"methylene blue") increases p(HGNC:BECN1)
pmid:29758300 a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B)
pmid:29758300 a(CHEBI:"methylene blue") decreases p(HGNC:MAPT)
pmid:30116051 a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT))
pmid:23528736 a(CHEBI:"methylene blue") decreases p(HGNC:MAPT)
pmid:29758300 a(CHEBI:"methylene blue") decreases p(HGNC:SQSTM1)
pmid:30116051 a(CHEBI:"methylene blue") decreases a(HBP:HBP00009)
pmid:30116051 a(CHEBI:"methylene blue") increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:"methylene blue") increases bp(GO:autophagy)
pmid:23528736 a(CHEBI:"methylene blue") increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:"methylene blue") increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK))
pmid:30116051 a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A)
pmid:30116051 a(CHEBI:"methylene blue") increases p(HGNC:DCTN4)
pmid:24027553 a(CHEBI:"methylene blue") increases bp(MESH:Autophagy)
pmid:22611162 a(CHEBI:"methylene blue") increases bp(GO:locomotion)
pmid:29191965 a(CHEBI:"methylene blue") positiveCorrelation bp(GO:locomotion)
pmid:22611162 a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates")
pmid:23528736 a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates")
pmid:29191965 a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates")
pmid:23528736 a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ph))
pmid:21882945 a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family"))
pmid:26751493 a(CHEBI:"methylene blue") decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1))
pmid:26751493 a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3))
pmid:23666762 a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(kin))
pmid:23666762 a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4))
pmid:28287136 a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ac))
pmid:25437566 a(CHEBI:ATP) association act(p(FPLX:HSP90))
pmid:23746257 a(CHEBI:ATP) regulates act(p(FPLX:HSP90))
pmid:25437566 a(CHEBI:ATP) association act(p(FPLX:HSPA))
pmid:23746257 a(CHEBI:ATP) regulates act(p(FPLX:HSPA))
pmid:25437566 a(CHEBI:ATP) association act(p(HGNC:HSPD1))
pmid:23746257 a(CHEBI:ATP) regulates act(p(HGNCGENEFAMILY:Chaperonins))
pmid:23746257 a(CHEBI:ATP) causesNoChange act(p(FPLX:HSPB))
pmid:23746257 a(CHEBI:ATP) regulates complex(p(HGNC:HSPD1), p(HGNC:HSPE1))
pmid:24457024 a(CHEBI:ATP) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin))
pmid:24457024 a(CHEBI:ATP) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome"))
pmid:27671637 a(CHEBI:ATP) positiveCorrelation a(GO:mitochondrion)
pmid:24561250 a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex"))
pmid:24561250 a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex"))
pmid:24561250 a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:29758300 p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?"))
pmid:30116051 act(p(HGNC:CASP3)) increases p(HGNC:BECN1, frag("?"))
pmid:24027553 act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*"))
pmid:24027553 act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT))
pmid:29238289 act(p(HGNC:CASP3)) increases p(HGNC:MAPT)
pmid:24027553 act(p(HGNC:CASP3)) increases p(HBP:"Tau C3")
pmid:24027553 act(p(HGNC:CASP3)) increases p(HBP:"Tau C3")
pmid:25374103 act(p(HGNC:CASP3)) positiveCorrelation p(HBP:"Tau C3")
pmid:24027553 act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25374103 act(p(HGNC:CASP3)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)")
pmid:26631930 p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?"))
pmid:26631930 p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421"))
pmid:27068745 p(HGNC:CASP3) association act(p(FPLX:JNK))
pmid:27068745 p(HGNC:CASP3) association act(p(HGNC:MAP3K5))
pmid:27068745 p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process")
pmid:27314526 act(p(HGNC:CASP3)) increases bp(GO:"neuron death")
pmid:30444369 p(HGNC:BCL2L11) increases bp(GO:"apoptotic process")
pmid:23528736 p(HGNC:BCL2L11) decreases bp(GO:autophagy)
pmid:30444369 act(p(HGNC:PRDX2)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:30444369 p(HGNC:PRDX2) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30444369 p(HGNC:PRDX2, pmod(Ph, Thr, 89)) decreases act(p(HGNC:PRDX2))
pmid:30444369 p(HGNC:SH3GL2) increases bp(GO:"synaptic vesicle endocytosis")
pmid:30444369 p(HGNC:SH3GL2) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30444369 p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1))
pmid:30444369 p(HGNC:SH3GL2) association bp(GO:"neuron projection development")
pmid:30444369 p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity")
pmid:30444369 p(HGNC:SH3GL2) association bp(GO:"neuron death")
pmid:30444369 bp(GO:"neuron projection development") association p(HGNC:SH3GL2)
pmid:20133804 bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4)
pmid:30444369 a(HBP:AG18051) decreases act(p(HGNC:HSD17B10))
pmid:30444369 a(HBP:AG18051) decreases act(a(HBP:"amyloid-beta aggregates"))
pmid:30444369 a(HBP:"RM-532-46") decreases act(p(HGNC:HSD17B10))
pmid:30444369 a(PUBCHEM:33334) decreases complex(p(HGNC:APP), p(HGNC:HSD17B10))
pmid:30444369 a(PUBCHEM:33334) decreases act(p(HGNC:CSNK1A1))
pmid:30444369 p(HGNC:CSNK1A1) increases p(HGNC:MAPT, pmod(Ph))
pmid:30444369 p(HGNC:CSNK1A1) regulates act(p(FPLX:"Gamma_secretase"))
pmid:30444369 p(HGNC:CSNK1A1) association a(HBP:"amyloid-beta aggregates")
pmid:25974414 act(p(HGNC:CSNK1A1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17))
pmid:25673844 p(HGNC:CSNK1A1) isA p(FPLX:CSNK1)
pmid:25546293 p(HGNC:CSNK1A1) increases p(HGNC:CTNNB1, pmod(Ph, Ser, 35))
pmid:30444369 a(PUBCHEM:208907) decreases act(p(HGNC:MAOA))
pmid:30444369 a(PUBCHEM:208907) causesNoChange act(p(HGNC:CSNK1A1))
pmid:22040696 path(MESH:"Neurodegenerative Diseases") association p(HGNC:CHRNA7)
pmid:29758300 path(MESH:"Neurodegenerative Diseases") positiveCorrelation a(HBP:"protein aggregates")
pmid:29758300 path(MESH:"Neurodegenerative Diseases") association bp(GO:"neuron death")
pmid:22908190 path(MESH:"Neurodegenerative Diseases") association bp(GO:"regulation of endosome size")
pmid:25784053 path(MESH:"Neurodegenerative Diseases") association path(MESH:"Protein Aggregation, Pathological")
pmid:18930136 path(MESH:"Neurodegenerative Diseases") positiveCorrelation p(MESH:Proteins, pmod(HBP:misfolding))
pmid:18930136 path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy)
pmid:18930136 path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:autophagy)
pmid:29024336 path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies")
pmid:29024336 path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies")
pmid:24027553 path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains)
pmid:23528736 path(MESH:"Neurodegenerative Diseases") association p(HGNC:STUB1)
pmid:23528736 path(MESH:"Neurodegenerative Diseases") association p(HGNC:PRKN)
pmid:23528736 path(MESH:"Neurodegenerative Diseases") association p(HGNC:RNF182)
pmid:23528736 path(MESH:"Neurodegenerative Diseases") association p(HGNC:UCHL1, var("?"))
pmid:23528736 path(MESH:"Neurodegenerative Diseases") association p(HGNC:ATXN3, var("?"))
pmid:29191965 path(MESH:"Neurodegenerative Diseases") association bp(GO:"aggresome assembly")
pmid:29311797 path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging)
pmid:29196815 path(MESH:Smoking) increases path(MESH:"Alzheimer Disease")
pmid:21482353 path(MESH:Smoking) decreases path(MESH:"Parkinson Disease")
pmid:22807490 path(MESH:Smoking) association path(MESH:"Hashimoto Disease")
pmid:22807490 path(MESH:Smoking) association path(MESH:"Colitis, Ulcerative")
pmid:22807490 path(MESH:Smoking) negativeCorrelation p(HGNC:TPO)
pmid:28391535 path(MESH:Smoking) increases a(MESH:"Blood Glucose")
pmid:29196815 path(MESH:Obesity) increases path(MESH:"Alzheimer Disease")
pmid:29196815 path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease")
pmid:26195256 path(MESH:"Diabetes Mellitus") association path(MESH:"Alzheimer Disease")
pmid:29626319 path(MESH:"Diabetes Mellitus") negativeCorrelation p(HGNC:IDE)
pmid:29626319 path(MESH:"Diabetes Mellitus") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:29196815 g(HBP:HBP00030) increases path(MESH:"Alzheimer Disease")
pmid:26837465 complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1)
pmid:26837465 complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1)
pmid:24368848 complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons))
pmid:23407988 complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree")
pmid:10391244 complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39")))
pmid:10391244 complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1)
pmid:12714745 complex(GO:"neurofibrillary tangle") positiveCorrelation g(DBSNP:rs104893877)
pmid:29196815 a(HBP:HBP00074) increases bp(GO:"neuron death")
pmid:29196815 a(HBP:HBP00074) increases bp(GO:"neuron death")
pmid:29196815 a(HBP:HBP00074) positiveCorrelation bp(GO:"neuron death")
pmid:21718217 a(HBP:HBP00074) increases bp(GO:"neuron death")
pmid:29196815 a(HBP:HBP00074) decreases a(MESH:Synapses)
pmid:29196815 a(HBP:HBP00074) decreases a(MESH:Synapses)
pmid:29196815 a(HBP:HBP00074) decreases a(MESH:Synapses)
pmid:29196815 a(HBP:HBP00074) decreases bp(GO:memory)
pmid:29196815 a(HBP:HBP00074) decreases bp(GO:memory)
pmid:29196815 a(HBP:HBP00074) decreases bp(GO:memory)
pmid:29196815 a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29196815 a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29196815 a(HBP:HBP00074) decreases bp(GO:"neuronal signal transduction")
pmid:29196815 a(HBP:HBP00074) increases path(MESH:Dementia)
pmid:29196815 a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation")
pmid:29196815 a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation")
pmid:29196815 a(HBP:HBP00074) decreases bp(GO:"signal release from synapse")
pmid:29196815 a(HBP:HBP00074) increases bp(GO:"long term synaptic depression")
pmid:29196815 a(HBP:HBP00074) increases p(HGNC:APP, pmod(Ph))
pmid:29196815 a(HBP:HBP00074) increases path(MESH:"Neuroaxonal Dystrophies")
pmid:29196815 a(HBP:HBP00074) increases bp(GO:"microglial cell activation")
pmid:29196815 a(HBP:HBP00074) increases bp(GO:"astrocyte activation")
pmid:29196815 a(HBP:HBP00074) positiveCorrelation bp(GO:"astrocyte activation")
pmid:29196815 a(HBP:HBP00074) positiveCorrelation a(CHEBI:"amyloid fibril")
pmid:29196815 a(HBP:HBP00074) increases act(p(HGNC:GRIN1))
pmid:29196815 a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA1), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29196815 a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29196815 a(HBP:HBP00074) increases act(p(HGNC:NGFR))
pmid:29196815 a(HBP:HBP00074) decreases p(HGNC:INSR)
pmid:29196815 a(HBP:HBP00074) negativeCorrelation a(HBP:HBP00352)
pmid:29196815 a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:29196815 a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:21718217 a(HBP:HBP00074) decreases bp(GO:"synaptic signaling")
pmid:19293145 a(MESH:Synapses) increases bp(GO:cognition)
pmid:29196815 a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory)
pmid:29196815 a(CHEBI:"amyloid fibril") positiveCorrelation a(HBP:HBP00074)
pmid:19126755 path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 path(MESH:Dementia) association path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:Dementia) association path(MESH:"Alzheimer Disease")
pmid:25514383 path(MESH:Dementia) association path(MESH:"Alzheimer Disease")
pmid:26813123 path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic")
pmid:25514383 path(MESH:Dementia) association bp(GO:aging)
pmid:29758300 path(MESH:Dementia) association path(MESH:Tauopathies)
pmid:22908190 path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body")
pmid:22908190 path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body")
pmid:22908190 path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(Ub))
pmid:26631930 path(MESH:Dementia) negativeCorrelation p(HGNC:MAPT)
pmid:27314526 path(MESH:Dementia) association sec(a(MESH:Interleukins))
pmid:27314526 path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B)
pmid:27314526 path(MESH:Dementia) positiveCorrelation p(HGNC:IL18)
pmid:24653673 p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:GSK3B))
pmid:24653673 p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:CDK5))
pmid:24653673 p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(FPLX:ERK))
pmid:24653673 p(HGNC:APP, pmod(Ph)) positiveCorrelation a(CHEBI:homocysteine)
pmid:24653673 p(HGNC:APP, pmod(Ph)) negativeCorrelation p(FPLX:PPP2, pmod(Me))
pmid:29196815 bp(GO:"astrocyte activation") positiveCorrelation a(HBP:HBP00074)
pmid:27671637 bp(GO:"astrocyte activation") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27314526 bp(GO:"astrocyte activation") increases sec(p(HGNC:IL1B))
pmid:27314526 bp(GO:"astrocyte activation") increases sec(p(HGNC:IL6))
pmid:27314526 bp(GO:"astrocyte activation") increases sec(p(HGNC:IL18))
pmid:27314526 bp(GO:"astrocyte activation") increases sec(p(HGNC:NOS2))
pmid:29196815 act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part"))
pmid:29196815 act(p(HGNC:GRIN1)) increases path(HBP:HBP00068)
pmid:29196815 act(p(HGNC:GRIN1)) increases path(HBP:HBP00037)
pmid:29196815 act(p(HGNC:GRIN1)) decreases a(MESH:Synapses)
pmid:24760868 p(HGNC:GRIA1, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:24760868 p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:29196815 a(HBP:HBP00075) decreases p(MGI:Adrb2)
pmid:29196815 a(HBP:HBP00075) increases bp(GO:"microglial cell activation")
pmid:29196815 a(HBP:HBP00075) decreases bp(GO:"long-term synaptic potentiation")
pmid:29196815 complex(a(HBP:HBP00074), p(HGNC:PRNP)) decreases bp(GO:"regulation of synaptic plasticity")
pmid:29196815 p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril")
pmid:14556719 p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP))
pmid:14556719 tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP))
pmid:28420982 p(HGNC:PRNP) association a(HBP:"Tau oligomers")
pmid:29196815 a(HBP:HBP00023) increases a(CHEBI:"calcium(2+)")
pmid:29196815 a(HBP:HBP00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP))
pmid:29196815 a(HBP:HBP00023) decreases bp(GO:"signal release from synapse")
pmid:29196815 p(HGNC:NGFR) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29196815 p(HGNC:NGFR) positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:18986241 p(HGNC:NGFR) association bp(GO:"GO:1901214")
pmid:18986241 p(HGNC:NGFR) increases act(p(HGNC:BACE1))
pmid:18986241 p(HGNC:NGFR) increases a(CHEBI:"amyloid-beta")
pmid:18986241 act(p(HGNC:NGFR)) association bp(GO:"GO:0006665")
pmid:18986241 act(p(HGNC:NGFR)) increases bp(GO:"GO:0007254")
pmid:18986241 act(p(HGNC:NGFR)) increases bp(GO:"GO:0038061")
pmid:18986241 act(p(HGNC:NGFR)) increases bp(GO:"GO:0043491")
pmid:18986241 act(p(HGNC:NGFR)) increases bp(GO:"GO:0000165")
pmid:22142809 p(HGNC:NGFR) association p(HBP:RAC1b)
pmid:29196815 a(HBP:HBP00352) negativeCorrelation a(HBP:HBP00074)
pmid:29196815 path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074)
pmid:29196815 path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074)
pmid:29196815 path(MESH:"Cognitive Dysfunction") positiveCorrelation p(HGNC:NGFR)
pmid:19293145 path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:"amyloid-beta oligomers")
pmid:19293145 path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease")
pmid:26813123 path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:"Cognitive Dysfunction") association path(MESH:Schizophrenia)
pmid:26813123 path(MESH:"Cognitive Dysfunction") negativeCorrelation a(GO:synapse)
pmid:26813123 path(MESH:"Cognitive Dysfunction") association act(p(HGNC:CHRM1))
pmid:27522251 path(MESH:"Cognitive Dysfunction") increases path(MESH:"Plaque, Amyloid")
pmid:21482353 path(MESH:"Cognitive Dysfunction") association p(HGNC:LYNX1)
pmid:11230871 path(MESH:"Cognitive Dysfunction") negativeCorrelation p(FPLX:CHRN)
pmid:24027553 path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:Tauopathies)
pmid:30108137 path(MESH:"Cognitive Dysfunction") positiveCorrelation r(HGNC:TFEB)
pmid:30126037 path(MESH:"Cognitive Dysfunction") association p(HGNC:CDKN2A)
pmid:30126037 path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation")
pmid:19765634 path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8052688)
pmid:19765634 path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8063)
pmid:29196815 a(HBP:HBP00076) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29196815 a(HBP:HBP00076) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:18650430 p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:14556719 p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:18650430 p(HGNC:APP, var("?")) increases path(MESH:"Cerebral Amyloid Angiopathy, Familial")
pmid:14556719 p(HGNC:APP, var("?")) increases a(HBP:"amyloid-beta aggregates")
pmid:22908190 p(HGNC:APP, var("?")) increases bp(GO:endocytosis)
pmid:22908190 p(HGNC:APP, var("?")) negativeCorrelation act(a(MESH:Neurites))
pmid:28420982 path(MESH:"Cerebral Amyloid Angiopathy, Familial") association a(MESH:"Heparan Sulfate Proteoglycans")
pmid:18650430 act(p(HGNC:ADAM17), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16"))))
pmid:21214928 p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))
pmid:22122372 p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))
pmid:22122372 p(HGNC:ADAM17) increases a(HBP:HBP00067)
pmid:18650430 act(p(HGNC:ADAM9), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16"))))
pmid:22122372 p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))
pmid:22122372 p(HGNC:ADAM9) increases a(HBP:HBP00067)
pmid:18650430 act(p(HGNC:ADAM10), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16"))))
pmid:21214928 p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16"))))
pmid:21214928 p(HGNC:ADAM10) increases p(HBP:HBP00067)
pmid:21214928 p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta")
pmid:21214928 p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta")
pmid:22122372 p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta")
pmid:21214928 p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))
pmid:21214928 p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))
pmid:22122372 p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))
pmid:22122372 p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067)))
pmid:21214928 p(HGNC:ADAM10) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:21214928 act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22122372 p(HGNC:ADAM10) increases sec(p(HGNC:APP))
pmid:24590577 p(HGNC:ADAM10) increases deg(p(HGNC:APP))
pmid:22122372 p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067), a(HBP:HBP00072)))
pmid:22122372 p(HGNC:ADAM10) increases a(HBP:HBP00067)
pmid:22122372 p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid")
pmid:24590577 p(HGNC:ADAM10) increases a(HBP:"sAPP-alpha")
pmid:18650430 act(p(HGNC:BACE2), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16"))))
pmid:21214928 p(HGNC:BACE2) association rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:21214928 p(HGNC:BACE2) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:18650430 complex(FPLX:"Gamma_secretase") increases a(MESH:"Amyloid beta-Peptides")
pmid:18650430 complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071)
pmid:22122372 complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071)
pmid:21214928 complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:22122372 complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:21214928 complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00024)), products(a(CHEBI:"amyloid-beta"), a(HBP:HBP00072)))
pmid:21214928 complex(FPLX:"Gamma_secretase") increases p(HBP:HBP00024, frag("?"))
pmid:21214928 complex(FPLX:"Gamma_secretase") increases p(HGNC:NOTCH1, frag("?"))
pmid:21214928 complex(FPLX:"Gamma_secretase") increases p(FPLX:Cadherin, frag("?"))
pmid:21214928 complex(FPLX:"Gamma_secretase") increases p(HGNC:TYR, frag("?"))
pmid:21214928 complex(FPLX:"Gamma_secretase") increases p(HGNC:ERBB4, frag("?"))
pmid:21214928 complex(FPLX:"Gamma_secretase") increases p(HGNC:CD44, frag("?"))
pmid:22122372 complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00072)), products(a(HBP:HBP00071), a(HBP:HBP00080)))
pmid:22122372 complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00081)), products(a(HBP:HBP00071), a(MESH:"Amyloid beta-Peptides")))
pmid:22122372 complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38"))
pmid:22122372 complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_43"))
pmid:22122372 complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711"))
pmid:24590577 complex(FPLX:"Gamma_secretase") increases deg(a(HBP:C99))
pmid:24590577 complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta")
pmid:29626319 complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta")
pmid:24590577 complex(FPLX:"Gamma_secretase") increases a(HBP:AICD)
pmid:21718217 p(HGNC:APH1A) decreases p(HGNC:APP)
pmid:21718217 p(HGNC:APH1A) increases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:18650430 p(HGNC:APBA1) decreases a(CHEBI:"amyloid-beta")
pmid:18650430 p(HGNC:APBA1) decreases a(HBP:HBP00018)
pmid:18650430 p(HGNC:APBA1) regulates bp(HBP:HBP00073)
pmid:21214928 bp(HBP:HBP00073) association p(HGNC:RAB6A)
pmid:22122372 bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 654))
pmid:22122372 bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 668))
pmid:22122372 bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Ser, 665))
pmid:30116051 bp(HBP:HBP00073) association p(HGNC:LRRK2, var("?"))
pmid:18650430 p(HGNC:APBA2) decreases a(CHEBI:"amyloid-beta")
pmid:18650430 p(HGNC:APBA2) decreases a(HBP:HBP00018)
pmid:18650430 p(HGNC:APBA2) regulates bp(HBP:HBP00073)
pmid:18650430 p(HGNC:APBB1) decreases a(CHEBI:"amyloid-beta")
pmid:18650430 p(HGNC:APBB1) decreases a(HBP:HBP00018)
pmid:18650430 p(HGNC:APBB1) regulates bp(HBP:HBP00073)
pmid:18650430 p(HGNC:APBB1) increases a(HBP:HBP00071)
pmid:21214928 act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:APP)
pmid:21214928 act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:GSK3B)
pmid:21214928 act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:CD82)
pmid:21214928 act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:MME)
pmid:21214928 act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:BACE1)
pmid:21214928 act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:EGFR)
pmid:21214928 act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:LRP1)
pmid:21214928 a(HBP:HBP00071) increases bp(GO:"apoptotic process")
pmid:18650430 p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta")
pmid:21214928 p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta")
pmid:29758300 p(HGNC:SORL1) negativeCorrelation a(CHEBI:"amyloid-beta")
pmid:29758300 p(HGNC:SORL1) association path(MESH:"Alzheimer Disease")
pmid:21214928 bp(GO:"synapse assembly") association p(HGNC:APP)
pmid:30106381 bp(GO:"synapse assembly") association p(HGNC:ADNP)
pmid:30106381 bp(GO:"synapse assembly") association a(PUBCHEM:9832404)
pmid:18650430 composite(p(HGNC:APP), p(HGNC:CNTN2)) decreases bp(GO:neurogenesis)
pmid:26813123 p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons"))
pmid:26813123 p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons"))
pmid:26813123 p(HGNC:SLC5A7) increases a(CHEBI:choline)
pmid:26813123 p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons"))
pmid:26813123 p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine)
pmid:17293005 p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-beta"))
pmid:17293005 p(HGNC:BACE1, frag("67_78")) decreases a(HBP:"sAPP-beta")
pmid:17293005 p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-alpha"))
pmid:17293005 p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular))
pmid:17293005 p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha")
pmid:17293005 p(HGNC:BACE1, frag("67_78")) causesNoChange a(CHEBI:"amyloid-beta")
pmid:17293005 p(HGNC:BACE1, frag("67_78")) causesNoChange p(HGNC:ACTB)
pmid:17293005 p(HGNC:BACE1, frag("67_78")) causesNoChange act(p(HGNC:BACE1))
pmid:17293005 p(HGNC:BACE1, frag("67_78")) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:17293005 p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-beta"))
pmid:17293005 p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-alpha"))
pmid:17293005 p(HGNC:BACE1, frag("69_75")) causesNoChange a(CHEBI:"amyloid-beta")
pmid:17293005 p(HGNC:BACE1, frag("69_75")) causesNoChange p(HGNC:ACTB)
pmid:17293005 p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-beta"))
pmid:17293005 p(HGNC:BACE1, frag("228_236")) decreases a(HBP:"sAPP-beta")
pmid:17293005 p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-alpha"))
pmid:17293005 p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular))
pmid:17293005 p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha")
pmid:17293005 p(HGNC:BACE1, frag("228_236")) causesNoChange a(CHEBI:"amyloid-beta")
pmid:17293005 p(HGNC:BACE1, frag("228_236")) causesNoChange p(HGNC:ACTB)
pmid:17293005 p(HGNC:BACE1, frag("228_236")) causesNoChange act(p(HGNC:BACE1))
pmid:17293005 p(HGNC:BACE1, frag("228_236")) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:17293005 p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-beta"))
pmid:17293005 p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-alpha"))
pmid:17293005 p(HGNC:BACE1, frag("230_235")) causesNoChange a(CHEBI:"amyloid-beta")
pmid:17293005 p(HGNC:BACE1, frag("230_235")) causesNoChange p(HGNC:ACTB)
pmid:21214928 rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) association p(HGNC:BACE2)
pmid:21214928 a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:26813123 a(MESH:"Amyloid Precursor Protein Secretases") decreases a(MESH:"Amyloid beta-Peptides")
pmid:14556719 a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides")))
pmid:21214928 a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:21214928 a(MESH:Caspases) increases path(MESH:"Alzheimer Disease")
pmid:21214928 a(MESH:Caspases) increases rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070)))
pmid:21214928 a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069)))
pmid:21214928 a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00070)))
pmid:22122372 a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069), a(HBP:HBP00070)))
pmid:29215007 a(MESH:Caspases) increases p(HGNC:MAPT, var("?"))
pmid:21214928 bp(HBP:HBP00077) increases p(HBP:HBP00063)
pmid:21214928 bp(HBP:HBP00077) increases p(HBP:HBP00064)
pmid:21214928 bp(HBP:HBP00077) increases p(HBP:HBP00065)
pmid:22122372 bp(HBP:HBP00077) increases a(HBP:HBP00063)
pmid:22122372 bp(HBP:HBP00077) increases a(HBP:HBP00064)
pmid:21214928 p(HBP:HBP00064) association p(UNIPROT:A0A293M1A7)
pmid:21214928 p(HBP:HBP00064) increases path(MESH:"Plaque, Amyloid")
pmid:21214928 p(HBP:HBP00065) association p(UNIPROT:A0A293M1A7)
pmid:21214928 p(HBP:HBP00065) increases path(MESH:"Plaque, Amyloid")
pmid:21214928 p(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21214928 p(UNIPROT:A0A293M1A7) association p(HBP:HBP00064)
pmid:21214928 p(UNIPROT:A0A293M1A7) association p(HBP:HBP00065)
pmid:21214928 r(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21214928 bp(GO:"signal transduction") association p(HGNC:APP)
pmid:17403556 bp(GO:"signal transduction") increases complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT))
pmid:29311797 bp(GO:"signal transduction") association p(HGNC:HSP90AB1)
pmid:21214928 bp(GO:"protein transport") association p(HGNC:APP)
pmid:23746257 bp(GO:"protein transport") association p(FPLX:HSP90)
pmid:22122372 complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073)
pmid:22122372 complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073)
pmid:22122372 complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073)
pmid:27068745 p(HGNC:NTN1) decreases p(HGNC:UNC5C, var("p.Thr835Met"))
pmid:21214928 bp(GO:"anterograde axonal protein transport") association p(HGNC:APP)
pmid:21734277 bp(GO:"anterograde axonal protein transport") association p(HBP:"6D tau", frag("2_18"))
pmid:21214928 complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:BACE1))
pmid:21214928 complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:PSEN1))
pmid:19491104 p(HGNC:KIF5B) isA complex(GO:"kinesin complex")
pmid:19491104 p(HGNC:KIF5B) association complex(GO:microtubule)
pmid:26813123 complex(p(HGNC:APP), p(HGNC:SLC5A7)) increases tloc(p(HGNC:APP), fromLoc(GO:"cell surface"), toLoc(GO:intracellular))
pmid:21214928 a(HBP:HBP00067) decreases bp(HBP:HBP00061)
pmid:22122372 a(HBP:HBP00067) decreases bp(HBP:HBP00061)
pmid:22122372 sec(a(HBP:HBP00067)) decreases bp(HBP:HBP00061)
pmid:21214928 a(HBP:HBP00067) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:21214928 a(HBP:HBP00067) association bp(GO:"regulation of neuronal synaptic plasticity")
pmid:21214928 a(HBP:HBP00067) regulates bp(GO:"central nervous system formation")
pmid:21214928 a(HBP:HBP00067) decreases bp(HBP:HBP00068)
pmid:21214928 a(HBP:HBP00067) decreases bp(HBP:HBP00068)
pmid:21214928 a(HBP:HBP00067) regulates bp(GO:"stem cell proliferation")
pmid:21214928 a(HBP:HBP00067) decreases act(p(HGNC:CDK5))
pmid:21214928 a(HBP:HBP00067) association complex(p(HGNC:APBA1), p(HGNC:APP))
pmid:21214928 sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA1), p(HGNC:APP))
pmid:21214928 a(HBP:HBP00067) association complex(p(HGNC:APBA2), p(HGNC:APP))
pmid:21214928 sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA2), p(HGNC:APP))
pmid:21214928 a(HBP:HBP00067) association complex(p(HGNC:APBA3), p(HGNC:APP))
pmid:21214928 sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA3), p(HGNC:APP))
pmid:21214928 sec(a(HBP:HBP00067)) association a(CHEBI:"phorbol ester")
pmid:22122372 a(HBP:HBP00067) increases bp(GO:"cell adhesion")
pmid:22122372 a(HBP:HBP00067) increases bp(MESH:"Neuronal Outgrowth")
pmid:22122372 a(HBP:HBP00067) increases bp(GO:"synapse assembly")
pmid:22122372 a(HBP:HBP00067) increases bp(GO:learning)
pmid:22122372 a(HBP:HBP00067) increases bp(GO:memory)
pmid:21214928 composite(a(CHEBI:"phorbol ester"), p(HGNC:ADAM9), p(HGNC:APP)) increases a(HBP:HBP00067)
pmid:21214928 a(CHEBI:"phorbol ester") association sec(a(HBP:HBP00067))
pmid:21214928 a(CHEBI:"phorbol ester") association a(CHEBI:"amyloid-beta")
pmid:21214928 a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA))
pmid:21214928 bp(GO:"regulation of neuronal synaptic plasticity") association a(HBP:HBP00067)
pmid:12428809 bp(GO:"regulation of neuronal synaptic plasticity") association sec(p(HGNC:APP))
pmid:21214928 complex(p(HGNC:BACE1), p(HGNC:RTN4)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:21214928 complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
pmid:19126755 bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Alzheimer Disease")
pmid:19293145 bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta")
pmid:19293145 bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta")
pmid:24511233 bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition)
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition)
pmid:21482353 bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition)
pmid:24511233 bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior)
pmid:24511233 bp(GO:"synaptic transmission, cholinergic") association path(MESH:Schizophrenia)
pmid:17009926 bp(GO:"synaptic transmission, cholinergic") increases act(a(CHEBI:acetylcholine))
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") regulates act(a(MESH:Neurons))
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention)
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention)
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention)
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning)
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") positiveCorrelation bp(GO:learning)
pmid:21482353 bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning)
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory)
pmid:21482353 bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory)
pmid:22040696 bp(GO:"synaptic transmission, cholinergic") increases bp(GO:memory)
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress")
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, wakefulness")
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, sleep")
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing")
pmid:21482353 bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing")
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") regulates bp(GO:"circadian sleep/wake cycle")
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association bp(HBP:Neurodegeneration)
pmid:26813123 bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia)
pmid:24590577 bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Plaque, Amyloid")
pmid:24590577 bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Neurofibrillary Tangles")
pmid:21482353 bp(GO:"synaptic transmission, cholinergic") association path(MESH:Anxiety)
pmid:21482353 bp(GO:"synaptic transmission, cholinergic") association path(MESH:Depression)
pmid:21482353 bp(GO:"synaptic transmission, cholinergic") association p(HGNC:LYNX1)
pmid:11230871 bp(GO:"synaptic transmission, cholinergic") association a(PUBCHEM:5662)
pmid:21214928 p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038)
pmid:21214928 p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038)
pmid:22122372 p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038)
pmid:21214928 p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease")
pmid:21214928 p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022)
pmid:22122372 p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022)
pmid:21214928 p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid")
pmid:22122372 p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid")
pmid:22122372 p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid")
pmid:27094130 sec(p(HGNC:APP, frag("672_713"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin))
pmid:29540553 p(HGNC:APP, frag("672_713")) negativeCorrelation p(MGI:Sirt3)
pmid:29559585 p(HGNC:APP, frag("672_713")) increases p(MGI:Mapt, pmod(Ac))
pmid:29559585 p(HGNC:APP, frag("672_713")) increases a(CHEBI:"nitric oxide")
pmid:22122372 p(HGNC:APP, frag("672_711")) decreases bp(HBP:HBP00061)
pmid:27094130 sec(p(HGNC:APP, frag("672_711"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin))
pmid:24401760 p(HGNC:APP, frag("672_711")) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:21214928 path(MESH:"Down Syndrome") increases a(HBP:HBP00018)
pmid:17009926 path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN))
pmid:17009926 path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN)
pmid:26813123 path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons")
pmid:22299660 path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:PPP2)
pmid:22908190 path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size")
pmid:21214928 p(HGNC:CTSB) increases a(CHEBI:"amyloid-beta")
pmid:22122372 p(HGNC:CTSB) increases deg(a(CHEBI:"amyloid-beta"))
pmid:22908190 p(HGNC:CTSB) positiveCorrelation act(a(GO:synapse))
pmid:21214928 complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"synapse pruning")
pmid:21214928 complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"neuron death")
pmid:21214928 a(HBP:HBP00042) increases p(HGNC:TTR)
pmid:21214928 a(HBP:HBP00042) increases p(HGNC:KL)
pmid:22122372 a(HBP:HBP00042) increases bp(HBP:HBP00061)
pmid:21214928 bp(GO:"synapse pruning") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21))
pmid:21214928 a(HBP:HBP00024) increases bp(HBP:HBP00027)
pmid:22122372 act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 654))
pmid:22122372 act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 668))
pmid:22122372 act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Ser, 665))
pmid:22122372 p(HBP:HBP00071) increases bp(GO:"cell death")
pmid:22122372 p(HBP:HBP00071) increases p(HGNC:TP53)
pmid:22122372 p(HBP:HBP00071) increases act(p(HGNC:TP53))
pmid:22122372 p(HBP:HBP00071) regulates bp(GO:"calcium ion homeostasis")
pmid:22122372 a(HBP:HBP00069) increases bp(HBP:HBP00061)
pmid:22122372 a(HBP:HBP00069) increases act(p(HGNC:CASP3))
pmid:22122372 a(HBP:HBP00069) increases p(HGNC:APP, frag("672_713"))
pmid:22122372 a(HBP:HBP00070) increases bp(HBP:HBP00061)
pmid:21214928 complex(p(HGNC:APP), p(HGNC:NCSTN), p(HGNC:NOTCH1)) increases complex(complex(FPLX:"Gamma_secretase"), p(HGNC:APP))
pmid:21214928 p(HGNC:BSG) decreases a(CHEBI:"amyloid-beta")
pmid:21214928 p(HGNC:BSG) causesNoChange a(CHEBI:"amyloid-beta")
pmid:21214928 p(HGNC:TMED10) regulates a(CHEBI:"amyloid-beta")
pmid:21214928 complex(a(HBP:HBP00024), complex(FPLX:"Gamma_secretase"), p(HGNC:GSAP)) increases a(CHEBI:"amyloid-beta")
pmid:21718217 p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 act(p(HGNC:MME)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:28250274 p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta"))
pmid:30116051 p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:29626319 p(HGNC:MME) increases bp(GO:behavior)
pmid:28250274 p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A)
pmid:24653673 p(HGNC:EGFR) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307))
pmid:24653673 p(HGNC:EGFR) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307))
pmid:30640040 p(HGNC:EGFR) association a(PUBCHEM:24756910)
pmid:26195256 p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"))
pmid:26195256 p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Nephritis, Interstitial"), toLoc(MESH:Brain))
pmid:26195256 p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood))
pmid:29626319 p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta"))
pmid:21214928 complex(a(HBP:HBP00069), p(HGNC:APP)) increases bp(HBP:HBP00061)
pmid:22122372 bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(Ph))
pmid:22122372 bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease")
pmid:28420982 bp(GO:"neurofibrillary tangle assembly") association a(MESH:"Heparan Sulfate Proteoglycans")
pmid:19363271 bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(FPLX:HSP90)
pmid:23531502 bp(GO:"neurofibrillary tangle assembly") positiveCorrelation act(a(CHEBI:"hydrogen peroxide"))
pmid:26655600 bp(GO:"neurofibrillary tangle assembly") negativeCorrelation p(HBP:"3R tau")
pmid:17050703 bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:16816118 bp(GO:"neurofibrillary tangle assembly") negativeCorrelation act(p(HBP:"20 S Proteasome"))
pmid:22122372 a(HBP:HBP00038) increases path(MESH:"Plaque, Amyloid")
pmid:21718217 a(HBP:HBP00038) increases p(HGNC:CCL2)
pmid:21718217 a(HBP:HBP00038) increases bp(GO:"microglial cell activation")
pmid:21718217 act(a(HBP:HBP00038)) increases bp(GO:phagocytosis)
pmid:28019679 a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:24561250 a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:21718217 a(HBP:HBP00022) decreases bp(GO:"synaptic signaling")
pmid:21718217 a(HBP:HBP00022) increases bp(GO:"neuron death")
pmid:21214928 complex(a(CHEBI:"amyloid-beta"), p(HGNC:DNM1)) decreases bp(HBP:HBP00061)
pmid:19721446 p(HGNC:DNM1) association p(HGNC:CHRNB2)
pmid:29590627 act(p(HGNC:DNM1)) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:21214928 a(MESH:"Potassium Channels") association a(CHEBI:"amyloid-beta")
pmid:21214928 complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport")
pmid:21214928 complex(p(HGNC:APBA1), p(HGNC:APP)) association a(HBP:HBP00067)
pmid:21214928 complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(HBP:HBP00067))
pmid:21214928 complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:"amyloid-beta")
pmid:21214928 complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta"))
pmid:21214928 complex(p(HGNC:APBA2), p(HGNC:APP)) regulates bp(GO:"protein transport")
pmid:21214928 complex(p(HGNC:APBA2), p(HGNC:APP)) association a(HBP:HBP00067)
pmid:21214928 complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(HBP:HBP00067))
pmid:21214928 complex(p(HGNC:APBA2), p(HGNC:APP)) association a(CHEBI:"amyloid-beta")
pmid:21214928 complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta"))
pmid:21214928 complex(p(HGNC:APBA3), p(HGNC:APP)) regulates bp(GO:"protein transport")
pmid:21214928 complex(p(HGNC:APBA3), p(HGNC:APP)) association a(HBP:HBP00067)
pmid:21214928 complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(HBP:HBP00067))
pmid:21214928 complex(p(HGNC:APBA3), p(HGNC:APP)) association a(CHEBI:"amyloid-beta")
pmid:21214928 complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta"))
pmid:21214928 p(HGNC:RAB6A) association bp(HBP:HBP00073)
pmid:21214928 bp(GO:"clathrin-dependent endocytosis") increases deg(p(HGNC:APP))
pmid:26751493 bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT)
pmid:26751493 bp(GO:"clathrin-dependent endocytosis") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons))
pmid:27260836 bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits"))
pmid:21214928 complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP)
pmid:21214928 complex(p(HGNC:APP), p(HGNC:LRP1)) decreases p(HGNC:APP)
pmid:21214928 complex(p(HGNC:APP), p(HGNC:LRP1)) increases a(CHEBI:"amyloid-beta")
pmid:21214928 complex(p(HGNC:APP), p(HGNC:LRP1B)) decreases a(CHEBI:"amyloid-beta")
pmid:21214928 complex(p(HGNC:APP), p(HGNC:LRP1B)) increases sec(a(HBP:HBP00067))
pmid:21214928 a(CHEBI:estrogen) decreases a(CHEBI:"amyloid-beta")
pmid:19293145 a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta"))
pmid:11230871 a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta"))
pmid:21214928 a(CHEBI:estrogen) increases sec(a(HBP:HBP00067))
pmid:19293145 a(CHEBI:estrogen) decreases act(p(HBP:"APOE e4"))
pmid:11230871 a(CHEBI:estrogen) decreases path(MESH:"Alzheimer Disease")
pmid:21214928 act(p(HGNC:PRKCA)) increases sec(a(HBP:HBP00067))
pmid:21214928 p(HGNC:PRKCA) increases sec(a(HBP:HBP00067))
pmid:21214928 p(HGNC:PRKCA) decreases a(CHEBI:"amyloid-beta")
pmid:21214928 p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(Ph, Ser, 655))
pmid:22122372 p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 654))
pmid:22122372 p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 668))
pmid:22122372 p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Ser, 665))
pmid:21214928 p(HGNC:RAB11A) decreases a(CHEBI:"amyloid-beta")
pmid:21214928 a(CHEBI:testosterone) decreases path(MESH:"Plaque, Amyloid")
pmid:21214928 a(CHEBI:testosterone) decreases r(HGNC:BACE1)
pmid:21214928 a(CHEBI:testosterone) decreases p(HGNC:BACE1)
pmid:21214928 a(CHEBI:testosterone) decreases act(p(HGNC:BACE1))
pmid:21214928 a(CHEBI:testosterone) decreases p(HGNC:PSEN1)
pmid:22122372 a(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22122372 a(HBP:HBP00078) association p(HGNC:APP)
pmid:22122372 a(HBP:HBP00078) increases complex(p(HGNC:APP), p(HGNC:APP))
pmid:22122372 a(HBP:HBP00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1))
pmid:22122372 a(HBP:HBP00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2))
pmid:22122372 a(HBP:HBP00079) association p(HGNC:APP)
pmid:22122372 a(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22122372 composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) decreases path(MESH:"Perinatal Death")
pmid:29221819 p(MGI:App) negativeCorrelation p(MGI:Dyrk1a)
pmid:22122372 p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713"))
pmid:29758300 p(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:PSEN1, var("?")) decreases act(a(MESH:"Vacuolar Proton-Translocating ATPases"))
pmid:14556719 p(HGNC:PSEN1, var("?")) association act(complex(GO:"gamma-secretase complex"))
pmid:14556719 p(HGNC:PSEN1, var("?")) increases a(CHEBI:"amyloid-beta")
pmid:22908190 p(HGNC:PSEN1, var("?")) decreases bp(GO:"lysosomal protein catabolic process")
pmid:22908190 p(HGNC:PSEN1, var("?")) decreases act(a(HBP:Neurites))
pmid:22908190 p(HGNC:PSEN1, var("?")) decreases bp(GO:"pH reduction")
pmid:22908190 p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Neurites))
pmid:22122372 p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713"))
pmid:14556719 p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex"))
pmid:14556719 p(HGNC:PSEN2, var("?")) increases a(CHEBI:"amyloid-beta")
pmid:22122372 a(MESH:"Receptors, Cell Surface") association p(HGNC:APP)
pmid:22122372 complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073)
pmid:22122372 complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073)
pmid:22122372 complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP1), p(HGNC:APP))
pmid:22122372 complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP2), p(HGNC:APP))
pmid:22122372 complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APP), p(HGNC:APP))
pmid:22122372 complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death")
pmid:22122372 complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning")
pmid:12428809 p(HGNC:KLC1) increases bp(GO:"anterograde axonal transport")
pmid:19491104 act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex"))
pmid:19491104 p(HGNC:KLC1) isA complex(GO:"kinesin complex")
pmid:19491104 p(HGNC:KLC1) association p(HGNC:MAPK8IP1)
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:APBA1)) decreases a(CHEBI:"amyloid-beta")
pmid:22122372 p(HBP:HBP00071, pmod(Ph, Thr, 654)) association bp(HBP:HBP00073)
pmid:22122372 p(HBP:HBP00071, pmod(Ph, Thr, 654)) association act(p(HBP:HBP00071))
pmid:22122372 p(HBP:HBP00071, pmod(Ph, Thr, 668)) association bp(HBP:HBP00073)
pmid:22122372 p(HBP:HBP00071, pmod(Ph, Thr, 668)) association act(p(HBP:HBP00071))
pmid:22122372 p(HBP:HBP00071, pmod(Ph, Ser, 665)) association bp(HBP:HBP00073)
pmid:22122372 p(HBP:HBP00071, pmod(Ph, Ser, 665)) association act(p(HBP:HBP00071))
pmid:22122372 a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 654))
pmid:22122372 a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 668))
pmid:22122372 a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Ser, 665))
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:CD82)
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:MME)
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:TP53)
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:GSK3B)
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:EGFR)
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:LRP1)
pmid:22122372 act(p(HGNC:TP53)) increases bp(GO:"apoptotic process")
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:TFCP2)) increases p(HGNC:GSK3B)
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) regulates p(HGNC:APP, pmod(Ph, Thr, 668))
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) association a(HBP:HBP00073)
pmid:19491104 act(p(HGNC:MAPK8IP1)) positiveCorrelation act(complex(GO:"kinesin complex"))
pmid:19491104 p(HGNC:MAPK8IP1) isA complex(GO:"kinesin complex")
pmid:19491104 p(HGNC:MAPK8IP1) association p(HGNC:KLC1)
pmid:27094130 p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_711")))
pmid:27094130 p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_713")))
pmid:22122372 a(HBP:HBP00073) association complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1))
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"protein neddylation")
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:NAE1)) decreases p(HGNC:CTNNB1)
pmid:22122372 complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"apoptotic process")
pmid:18494933 deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1)
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC)
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion")
pmid:24511233 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates act(a(CHEBI:acetylcholine))
pmid:19721446 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") increases act(a(CHEBI:acetylcholine))
pmid:24511233 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") isA p(MESH:"Receptors, G-Protein-Coupled")
pmid:24511233 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates bp(GO:cognition)
pmid:24590577 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:"Alzheimer Disease")
pmid:24590577 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:memory)
pmid:24590577 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention)
pmid:24590577 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Nociception)
pmid:24590577 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:"circadian sleep/wake cycle")
pmid:24590577 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Cardiovascular System")
pmid:24590577 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:Kidney)
pmid:24590577 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Gastrointestinal Tract")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Electric Fish")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases bp(GO:"response to nicotine")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:19721446 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Alzheimer Disease")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:Schizophrenia)
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta polypeptide 42")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:anandamide)
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:anandamide)
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"cation transport")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(MESH:Sodium, loc(GO:intracellular))
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"membrane depolarization")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"positive regulation of voltage-gated calcium channel activity")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular))
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"inflammatory response")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"keratinocyte migration")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"ERK1 and ERK2 cascade")
pmid:19126755 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"receptor signaling pathway via JAK-STAT")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Rats, Inbred Strains")
pmid:19126755 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:Aging)
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta")
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta")
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates sec(a(CHEBI:"amyloid-beta"))
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:"amyloid-beta"))
pmid:19293145 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta")
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases path(HBP:neurotoxicity)
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(HBP:neurotoxicity)
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:nicotine)
pmid:19293145 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:"N-methyl-4-phenylpyridinium"))
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Neuroprotection)
pmid:19293145 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K))
pmid:19293145 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2)
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis")
pmid:19293145 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE)
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association p(HGNC:APOE)
pmid:19293145 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(HBP:"sAPP-beta"))
pmid:19293145 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"apoptotic process")
pmid:19293145 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24511233 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:acetylcholine))
pmid:19721446 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:acetylcholine))
pmid:19721446 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Peripheral Nervous System")
pmid:19721446 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Central Nervous System")
pmid:19721446 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:dopamine))
pmid:19721446 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:serotonin))
pmid:19721446 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"glutamate(2-)"))
pmid:19721446 act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:cholesterol)
pmid:19721446 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating")
pmid:19126755 a(TAXONOMY:41956) increases a(CHEBI:Muscarine)
pmid:19126755 a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic"))
pmid:19126755 a(TAXONOMY:33113) increases a(CHEBI:atropine)
pmid:19126755 a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic"))
pmid:19126755 a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic"))
pmid:19126755 a(CHEBI:atropine) decreases bp(GO:"cell adhesion")
pmid:26813123 a(CHEBI:atropine) decreases act(p(FPLX:CHRM))
pmid:26751493 p(FPLX:PLC) association p(HBP:"projection domain")
pmid:26751493 p(FPLX:PLC) association a(HBP:"projection domain")
pmid:29626319 a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT))
pmid:29758300 a(CHEBI:"calcium ion") increases act(a(MESH:"Vacuolar Proton-Translocating ATPases"))
pmid:19126755 a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:nicotine) decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum")))
pmid:19126755 a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(CHEBI:nicotine) regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(CHEBI:nicotine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19293145 a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19721446 a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19721446 act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:nicotine) causesNoChange a(MESH:Manduca)
pmid:19126755 a(CHEBI:nicotine) association path(HBP:neurotoxicity)
pmid:19293145 a(CHEBI:nicotine) decreases path(HBP:neurotoxicity)
pmid:19126755 a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 a(CHEBI:nicotine) decreases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR")
pmid:18174175 a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR")
pmid:19126755 a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-4 nAChR")
pmid:19126755 a(CHEBI:nicotine) decreases complex(p(HGNC:CHRNA6), p(HGNC:CHRNB3))
pmid:19126755 a(CHEBI:nicotine) increases act(p(FPLX:PI3K))
pmid:19293145 a(CHEBI:nicotine) increases act(p(FPLX:PI3K))
pmid:19126755 a(CHEBI:nicotine) increases act(p(FPLX:PKA))
pmid:19126755 a(CHEBI:nicotine) increases act(p(FPLX:PKC))
pmid:19126755 a(CHEBI:nicotine) increases act(p(FPLX:"CAMK2_complex"))
pmid:19126755 act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB))
pmid:19126755 act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2))
pmid:19126755 act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1))
pmid:19126755 act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3))
pmid:19293145 act(a(CHEBI:nicotine)) association act(p(HGNC:STAT3))
pmid:19126755 act(a(CHEBI:nicotine)) association a(MESH:Skin)
pmid:19126755 act(a(CHEBI:nicotine)) regulates bp(GO:"inflammatory response")
pmid:23178521 a(CHEBI:nicotine) regulates bp(GO:"inflammatory response")
pmid:19126755 a(CHEBI:nicotine) decreases path(MESH:"Colitis, Ulcerative")
pmid:19126755 a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases")
pmid:19126755 a(CHEBI:nicotine) decreases sec(p(HGNC:TNF))
pmid:19293145 a(CHEBI:nicotine) regulates act(p(HGNC:TNF))
pmid:19126755 act(a(CHEBI:nicotine)) association path(MESH:"Genetic Variation")
pmid:19126755 a(CHEBI:nicotine) causesNoChange path(MESH:"Alzheimer Disease")
pmid:19126755 a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4)
pmid:19126755 a(CHEBI:nicotine) decreases act(a(CHEBI:"NS-398"))
pmid:19126755 a(CHEBI:nicotine) decreases bp(GO:"neuron death")
pmid:19126755 a(CHEBI:nicotine) decreases bp(GO:"neuron death")
pmid:19126755 a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine))
pmid:17009926 a(CHEBI:nicotine) decreases sec(a(CHEBI:dopamine))
pmid:21482353 a(CHEBI:nicotine) decreases a(CHEBI:dopamine)
pmid:21482353 a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Presynaptic Terminals"), toLoc(GO:"extracellular region"))
pmid:19721446 a(CHEBI:nicotine) regulates sec(a(CHEBI:dopamine))
pmid:28391535 a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine))
pmid:28391535 a(CHEBI:nicotine) increases act(a(CHEBI:dopamine))
pmid:19126755 a(CHEBI:nicotine) increases path(MESH:"Behavior, Addictive")
pmid:19126755 a(CHEBI:nicotine) increases path(MESH:Craving)
pmid:19126755 a(CHEBI:nicotine) increases path(MESH:Anxiety)
pmid:19126755 a(CHEBI:nicotine) association act(p(HGNC:CHRNA7))
pmid:19293145 act(a(CHEBI:nicotine)) increases p(HGNC:CHRNA7)
pmid:17009926 a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7))
pmid:26472524 a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:nicotine) association a(HBP:"beta-2-containing nAChR")
pmid:19293145 a(CHEBI:nicotine) increases bp(MESH:Neuroprotection)
pmid:19293145 act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection)
pmid:19293145 act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection)
pmid:19293145 act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection)
pmid:19293145 a(CHEBI:nicotine) increases bp(MESH:Neuroprotection)
pmid:19721446 a(CHEBI:nicotine) association bp(MESH:Neuroprotection)
pmid:19293145 a(CHEBI:nicotine) increases a(CHEBI:acetylcholine)
pmid:19293145 a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin))
pmid:19293145 act(a(CHEBI:nicotine)) decreases act(a(CHEBI:methamphetamine))
pmid:19293145 a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process")
pmid:19293145 act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(Ph))
pmid:19293145 act(a(CHEBI:nicotine)) increases p(HGNC:BCL2)
pmid:19293145 act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1)
pmid:19293145 a(CHEBI:nicotine) increases p(HGNC:BAX, pmod(Ph))
pmid:19293145 a(CHEBI:nicotine) decreases bp(GO:"apoptotic process")
pmid:19293145 a(CHEBI:nicotine) decreases bp(GO:"apoptotic process")
pmid:25514383 a(CHEBI:nicotine) decreases bp(GO:"apoptotic process")
pmid:19293145 a(CHEBI:nicotine) decreases tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion))
pmid:19293145 a(CHEBI:nicotine) increases act(p(HGNC:BAD))
pmid:19293145 a(CHEBI:nicotine) increases complex(p(FPLX:"PI3K_p85"), p(HGNC:CHRNA7), p(HGNC:FYN))
pmid:19293145 act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:nicotine) association p(HGNC:STAT3, pmod(Ph))
pmid:19293145 act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(Ph))
pmid:19293145 act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(Ph))
pmid:19293145 act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(Ph))
pmid:19293145 a(CHEBI:nicotine) increases act(g(HGNC:NIN))
pmid:19293145 a(CHEBI:nicotine) increases act(g(HGNC:PTGS2))
pmid:19293145 a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E1(1-)")
pmid:19293145 a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade")
pmid:19293145 a(CHEBI:nicotine) increases bp(GO:"MAPK cascade")
pmid:19293145 act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3))
pmid:19293145 a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid"))
pmid:19293145 a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides)
pmid:19293145 a(CHEBI:nicotine) association bp(GO:"calcium-mediated signaling")
pmid:19293145 a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")
pmid:19293145 a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Ryanodine receptors")
pmid:19293145 a(CHEBI:nicotine) association p(FPLX:ERK)
pmid:19293145 act(a(CHEBI:nicotine)) association a(MESH:Calcineurin)
pmid:19293145 a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)")
pmid:19293145 a(CHEBI:nicotine) increases sec(a(HBP:"sAPP-beta"))
pmid:19293145 a(CHEBI:nicotine) decreases a(HBP:"sAPP-gamma")
pmid:17009926 a(CHEBI:nicotine) increases act(p(FPLX:CHRN))
pmid:17009926 a(CHEBI:nicotine) increases act(p(FPLX:CHRN))
pmid:28445721 a(CHEBI:nicotine) regulates p(FPLX:CHRN)
pmid:21482353 a(CHEBI:nicotine) increases act(p(FPLX:CHRN))
pmid:21482353 a(CHEBI:nicotine) increases p(FPLX:CHRN)
pmid:21482353 a(CHEBI:nicotine) increases p(FPLX:CHRN)
pmid:21482353 a(CHEBI:nicotine) causesNoChange p(FPLX:CHRN)
pmid:21787755 a(CHEBI:nicotine) increases act(p(FPLX:CHRN))
pmid:17009926 a(CHEBI:nicotine) increases bp(GO:memory)
pmid:25514383 a(CHEBI:nicotine) increases bp(GO:memory)
pmid:11230871 a(CHEBI:nicotine) increases bp(GO:memory)
pmid:11230871 a(CHEBI:nicotine) increases bp(GO:memory)
pmid:17009926 a(CHEBI:nicotine) increases bp(GO:"circadian sleep/wake cycle, wakefulness")
pmid:26813123 a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic"))
pmid:21958873 a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic"))
pmid:28391535 a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic"))
pmid:25514383 a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25514383 a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25514383 a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:25514383 a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:25514383 a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta")
pmid:21958873 a(CHEBI:nicotine) causesNoChange a(CHEBI:"amyloid-beta")
pmid:25514383 a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:25514383 a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:21482353 a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:21482353 a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 a(CHEBI:nicotine) increases path(MESH:"Memory, Episodic")
pmid:25514383 a(CHEBI:nicotine) increases path(MESH:"Spatial Memory")
pmid:25514383 a(CHEBI:nicotine) decreases a(HBP:"amyloid-beta oligomers")
pmid:25514383 a(CHEBI:nicotine) increases a(HBP:"Tau aggregates")
pmid:25514383 a(CHEBI:nicotine) increases a(HBP:"Tau aggregates")
pmid:25514383 a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade")
pmid:25514383 a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid")
pmid:19721446 a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid")
pmid:25514383 a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation")
pmid:21482353 a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation")
pmid:28445721 a(CHEBI:nicotine) increases surf(p(HBP:HBP00174))
pmid:28445721 a(CHEBI:nicotine) increases a(HBP:HBP00174)
pmid:21482353 a(CHEBI:nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2))
pmid:21482353 a(CHEBI:nicotine) increases act(p(MGI:Lynx1))
pmid:21482353 a(CHEBI:nicotine) increases bp(GO:cognition)
pmid:19721446 a(CHEBI:nicotine) increases bp(GO:cognition)
pmid:21482353 a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:21482353 a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:21482353 a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:21482353 a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:21482353 a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:18174175 a(CHEBI:nicotine) increases a(HBP:"alpha-4 beta-2 nAChR")
pmid:21482353 a(CHEBI:nicotine) causesNoChange a(HBP:"alpha-4-containing nAChR")
pmid:21482353 a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR"))
pmid:21482353 a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR"))
pmid:21482353 a(CHEBI:nicotine) increases tloc(a(HBP:"alpha-4-containing nAChR"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"extracellular region"))
pmid:21482353 a(CHEBI:nicotine) decreases act(a(MESH:"Dopaminergic Neurons"))
pmid:21482353 a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons"))
pmid:21482353 a(CHEBI:nicotine) decreases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy")
pmid:11230871 a(CHEBI:nicotine) increases bp(GO:learning)
pmid:11230871 a(CHEBI:nicotine) increases path(MESH:Attention)
pmid:19721446 a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating")
pmid:19721446 act(a(CHEBI:nicotine)) association p(HGNC:CHRNB4)
pmid:19721446 act(a(CHEBI:nicotine)) association p(HGNC:CHRNA2)
pmid:19721446 act(a(CHEBI:nicotine)) association p(HGNC:CHRNA5)
pmid:19721446 act(a(CHEBI:nicotine)) decreases path(MESH:Nociception)
pmid:22040696 a(CHEBI:nicotine) increases act(a(MESH:"SNARE Proteins"))
pmid:18174175 a(CHEBI:nicotine) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")
pmid:21958873 a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-beta"))
pmid:21958873 a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-alpha"))
pmid:21958873 a(CHEBI:nicotine) causesNoChange act(complex(GO:"NF-kappaB complex"))
pmid:23178521 a(CHEBI:nicotine) decreases act(p(FPLX:NFkappaB))
pmid:28391535 a(CHEBI:nicotine) increases act(a(MESH:"Adrenal Glands"))
pmid:28391535 a(CHEBI:nicotine) increases sec(a(CHEBI:adrenaline))
pmid:28391535 a(CHEBI:nicotine) decreases sec(a(CHEBI:"insulin (human)"))
pmid:28391535 a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2"))
pmid:28391535 a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2"))
pmid:28391535 a(CHEBI:nicotine) negativeCorrelation path(MESH:"Motor Activity")
pmid:28391535 a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"Receptors, Nicotinic"))
pmid:28391535 a(CHEBI:nicotine) causesNoChange act(a(CHEBI:Mecamylamine))
pmid:28391535 act(a(CHEBI:nicotine)) negativeCorrelation a(CHEBI:Hexamethonium)
pmid:19126755 a(MESH:"Electric Fish") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(HBP:"alpha-Bungarotoxin") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(HBP:"alpha-Bungarotoxin") increases complex(a(HBP:"alpha-Bungarotoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(HBP:"alpha-Bungarotoxin") decreases a(CHEBI:dopamine, loc(GO:"extracellular region"))
pmid:21482353 a(HBP:"alpha-Bungarotoxin") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:19126755 bp(GO:signaling) association a(CHEBI:acetylcholine)
pmid:19126755 act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine)))
pmid:26813123 p(HGNC:CHAT) increases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine)))
pmid:19293145 p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE)
pmid:26813123 act(p(HGNC:CHAT)) negativeCorrelation path(MESH:"Huntington Disease")
pmid:26813123 act(p(HGNC:CHAT)) decreases path(MESH:Dementia)
pmid:16273023 act(p(HGNC:CHAT), ma(cat)) increases a(CHEBI:acetylcholine)
pmid:24590577 p(HGNC:CHAT) decreases a(CHEBI:acetylcholine)
pmid:25514383 act(p(HGNC:CHAT)) increases a(CHEBI:acetylcholine)
pmid:18986241 act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine)
pmid:19721446 p(HGNC:CHAT) increases a(CHEBI:acetylcholine)
pmid:18986241 act(p(HGNC:CHAT)) decreases bp(HBP:Neurodegeneration)
pmid:28002468 a(CHEBI:"acetyl-CoA") increases a(HBP:"cystein-dependent auto-acetylation")
pmid:17009926 a(CHEBI:choline) increases act(p(FPLX:CHRN))
pmid:26813123 a(CHEBI:choline) increases a(CHEBI:acetylcholine)
pmid:26088141 act(a(CHEBI:choline)) increases a(CHEBI:"calcium(2+)")
pmid:26088141 act(a(CHEBI:choline)) association act(a(MESH:"Calcium Channels"))
pmid:26088141 a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains")
pmid:26088141 a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains")
pmid:26088141 a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7))
pmid:26088141 a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ))
pmid:26088141 a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta"))
pmid:21482353 a(CHEBI:choline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:21482353 a(CHEBI:choline) increases act(a(HBP:"alpha-7-containing nAChR"))
pmid:19721446 a(CHEBI:choline) increases bp(MESH:Neuroprotection)
pmid:19721446 a(CHEBI:choline) decreases act(a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid"))
pmid:26813123 p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic")
pmid:26813123 p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic")
pmid:26813123 p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic")
pmid:26813123 p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic")
pmid:26813123 p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic")
pmid:19721446 p(HGNC:CHRNA2) association act(a(CHEBI:nicotine))
pmid:26813123 p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic")
pmid:11230871 p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:11230871 p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19721446 p(HGNC:CHRNA3) association path(MESH:Craving)
pmid:19721446 p(HGNC:CHRNA3) association path(MESH:Recurrence)
pmid:19126755 p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:11230871 p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19126755 p(HGNC:CHRNA4) association p(HGNC:PTGS2)
pmid:19293145 p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:17009926 p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:19293145 act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)"))
pmid:19293145 act(p(HGNC:CHRNA4)) increases act(a(CHEBI:nicotine))
pmid:19721446 p(HGNC:CHRNA4) increases act(a(CHEBI:nicotine))
pmid:19293145 p(HGNC:CHRNA4) association bp(GO:"lipid metabolic process")
pmid:23038257 p(HGNC:CHRNA4) association p(MESH:"Cytoskeletal Proteins")
pmid:23038257 p(HGNC:CHRNA4) association bp(GO:"intracellular receptor signaling pathway")
pmid:17009926 p(HGNC:CHRNA4) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:26813123 p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic")
pmid:11230871 p(HGNC:CHRNA4) decreases complex(a(CHEBI:cytisine), p(FPLX:CHRN))
pmid:19126755 p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases")
pmid:26813123 p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic")
pmid:19721446 p(HGNC:CHRNA5) association act(a(CHEBI:nicotine))
pmid:26813123 p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic")
pmid:21787755 p(HGNC:CHRNA6) association path(MESH:Reward)
pmid:21787755 p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions")
pmid:21787755 p(HGNC:CHRNA6) association sec(a(CHEBI:dopamine))
pmid:19126755 p(HGNC:CHRNA7) association a(MESH:Neurons)
pmid:19126755 p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7))
pmid:19126755 p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2))
pmid:19126755 p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3))
pmid:19126755 act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation")
pmid:19126755 act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic")
pmid:19126755 act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular))
pmid:19126755 act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular))
pmid:19293145 act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)")
pmid:22040696 p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm))
pmid:19126755 act(p(HGNC:CHRNA7)) increases bp(GO:"neuronal action potential")
pmid:19126755 act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic")
pmid:19126755 act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) increases a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons"))
pmid:19126755 p(HGNC:CHRNA7, loc(MESH:"Mossy Fibers, Hippocampal")) regulates a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells"))
pmid:19293145 act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)"))
pmid:17009926 act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"glutamate(2-)"))
pmid:19126755 p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition)
pmid:19126755 act(p(HGNC:CHRNA7)) association bp(GO:cognition)
pmid:19721446 p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition)
pmid:19721446 act(p(HGNC:CHRNA7)) increases bp(GO:cognition)
pmid:19126755 p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease")
pmid:11230871 p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22040696 p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29191965 p(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19126755 act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:19126755 act(p(HGNC:CHRNA7)) regulates a(CHEBI:dopamine, loc(GO:"extracellular region"))
pmid:19126755 act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region"))
pmid:19126755 act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating")
pmid:19126755 act(p(HGNC:CHRNA7)) increases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:19293145 p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:19293145 p(HGNC:CHRNA7) decreases act(a(CHEBI:"amyloid-beta"))
pmid:19293145 p(HGNC:CHRNA7) increases a(CHEBI:"amyloid-beta")
pmid:19293145 p(HGNC:CHRNA7) association a(CHEBI:"amyloid-beta")
pmid:17009926 p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:29191965 p(HGNC:CHRNA7) regulates act(a(CHEBI:"amyloid-beta"))
pmid:19126755 act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide)
pmid:19126755 p(HGNC:CHRNA7) regulates bp(GO:"cell cycle")
pmid:19126755 act(p(HGNC:CHRNA7)) association a(CHEBI:nicotine)
pmid:19126755 p(HGNC:CHRNA7) regulates a(CHEBI:nicotine)
pmid:19293145 p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine))
pmid:19293145 p(HGNC:CHRNA7) increases a(CHEBI:nicotine)
pmid:19126755 p(HGNC:CHRNA7) regulates path(MESH:"Substance Withdrawal Syndrome")
pmid:19293145 p(HGNC:CHRNA7) association path(MESH:"Plaque, Amyloid")
pmid:19293145 p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine))
pmid:19293145 act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol))
pmid:19293145 act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death")
pmid:19293145 act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose)
pmid:19293145 act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen)
pmid:19293145 act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)"))
pmid:19293145 act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:"N-methyl-4-phenylpyridinium"))
pmid:19293145 act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS))
pmid:19293145 act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2))
pmid:19293145 p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade")
pmid:19293145 p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade")
pmid:19293145 act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport")
pmid:19293145 act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling")
pmid:19293145 p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors"))
pmid:17009926 p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion")
pmid:22040696 p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion")
pmid:17009926 p(HGNC:CHRNA7) increases act(complex(GO:"voltage-gated calcium channel complex"))
pmid:17009926 act(p(HGNC:CHRNA7)) increases bp(GO:"synaptic transmission, glutamatergic")
pmid:17009926 p(HGNC:CHRNA7) association a(HBP:"amyloid-beta aggregates")
pmid:17009926 p(HGNC:CHRNA7) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:26813123 p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic")
pmid:26088141 p(HGNC:CHRNA7) increases bp(HBP:"nAChR assembly")
pmid:26088141 p(HGNC:CHRNA7) increases p(HGNC:CHRNA7)
pmid:26088141 p(HGNC:CHRNA7) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ))
pmid:26088141 p(HGNC:CHRNA7) increases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7))
pmid:18986241 p(HGNC:CHRNA7) increases complex(p(HGNC:APP), p(HGNC:CHRNA7))
pmid:18986241 p(HGNC:CHRNA7) increases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))
pmid:19721446 p(HGNC:CHRNA7) association a(MESH:Hippocampus)
pmid:19721446 p(HGNC:CHRNA7) association bp(GO:memory)
pmid:19721446 act(p(HGNC:CHRNA7)) decreases bp(GO:memory)
pmid:19721446 p(HGNC:CHRNA7) association bp(GO:learning)
pmid:19721446 p(HGNC:CHRNA7) association bp(MESH:Neuroprotection)
pmid:19721446 act(p(HGNC:CHRNA7)) decreases bp(MESH:Neuroprotection)
pmid:19721446 p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating")
pmid:19721446 p(HGNC:CHRNA7) association a(CHEBI:clozapine)
pmid:22040696 p(HGNC:CHRNA7) regulates bp(GO:"chemical synaptic transmission")
pmid:22040696 p(HGNC:CHRNA7) regulates bp(GO:"neuron-neuron synaptic transmission")
pmid:22040696 p(HGNC:CHRNA7) association path(MESH:"Neurodegenerative Diseases")
pmid:22040696 p(HGNC:CHRNA7) association p(HGNC:BDNF)
pmid:22040696 tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(tscript))
pmid:22040696 p(HGNC:CHRNA7) negativeCorrelation path(MESH:Schizophrenia)
pmid:22040696 p(HGNC:CHRNA7) decreases path(MESH:"Renal Insufficiency")
pmid:22040696 p(HGNC:CHRNA7) decreases bp(GO:"cytokine production")
pmid:22040696 p(HGNC:CHRNA7) decreases bp(GO:"apoptotic process")
pmid:28901280 p(HGNC:CHRNA7) regulates bp(MESH:"Cell Survival")
pmid:28901280 p(HGNC:CHRNA7) regulates path(MESH:Inflammation)
pmid:28901280 p(HGNC:CHRNA7) association path(MESH:Neoplasms)
pmid:28901280 p(HGNC:CHRNA7) increases bp(GO:"intracellular receptor signaling pathway")
pmid:28901280 p(HGNC:CHRNA7) increases bp(GO:"JAK-STAT cascade")
pmid:29191965 p(HGNC:CHRNA7) regulates bp(GO:"musculoskeletal movement")
pmid:29191965 p(HGNC:CHRNA7) regulates act(a(GO:synapse))
pmid:29191965 p(HGNC:CHRNA7) association path(MESH:Tauopathies)
pmid:26813123 p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic")
pmid:28901280 p(HGNC:CHRNA9) increases path(MESH:Neoplasms)
pmid:26813123 p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic")
pmid:17009926 act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane")
pmid:26813123 p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic")
pmid:19721446 p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins)
pmid:19721446 p(HGNC:CHRNB2) association p(HGNC:DNM1)
pmid:19721446 p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits")
pmid:19721446 p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine))
pmid:26813123 p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic")
pmid:19126755 p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance")
pmid:26813123 p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic")
pmid:19721446 p(HGNC:CHRNB4) association act(a(CHEBI:nicotine))
pmid:19721446 p(HGNC:CHRNB4) association path(MESH:Craving)
pmid:19721446 p(HGNC:CHRNB4) association path(MESH:Recurrence)
pmid:19126755 p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:Aging)
pmid:19126755 p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19126755 p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19126755 p(HBP:"alpha-4 beta-2 nAChR") increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 act(p(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"synaptic transmission, GABAergic")
pmid:19126755 act(p(HBP:"alpha-4 beta-2 nAChR")) decreases act(complex(GO:"voltage-gated calcium channel complex"))
pmid:19126755 act(p(HBP:"alpha-4 beta-2 nAChR", loc(MESH:"GABAergic Neurons"))) increases act(a(MESH:"Dopaminergic Neurons"))
pmid:19126755 p(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition)
pmid:26472524 act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane")
pmid:19126755 p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease")
pmid:19126755 p(HBP:"alpha-7-containing nAChR") increases bp(GO:"calcium ion transport into cytosol")
pmid:26472524 p(HBP:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7))
pmid:19126755 a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier")
pmid:19126755 bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca)
pmid:19126755 a(MESH:Neurons) increases deg(a(CHEBI:nicotine))
pmid:19126755 a(MESH:Neurons) decreases r(HGNC:CHRNA3)
pmid:19126755 a(MESH:Neurons) increases r(HGNC:CHRNA4)
pmid:19126755 a(MESH:Neurons) association p(HGNC:CHRNA7)
pmid:19126755 a(MESH:Neurons) regulates a(CHEBI:"kynurenic acid")
pmid:21482353 a(MESH:Neurons) negativeCorrelation act(p(FPLX:CHRN))
pmid:21482353 a(MESH:Neurons) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:28901280 a(MESH:Neurons) association p(MESH:"Receptors, Nicotinic")
pmid:27671637 act(a(MESH:Neurons)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:29238289 act(a(MESH:Neurons)) increases p(HGNC:MAPT)
pmid:29238289 act(a(MESH:Neurons)) increases p(HGNC:MAPT)
pmid:29238289 a(MESH:Neurons) causesNoChange p(HGNC:MAPT)
pmid:27796283 act(a(MESH:Neurons)) increases p(HGNC:CAMKV)
pmid:27087442 act(a(MESH:Neurons)) positiveCorrelation p(MGI:Cdk5r1)
pmid:27087442 act(a(MESH:Neurons)) positiveCorrelation act(p(HBP:RAC1b))
pmid:27087442 act(a(MESH:Neurons)) negativeCorrelation p(MGI:Cdk5)
pmid:19126755 complex(a(MESH:"alpha-cobratoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) decreases act(p(HBP:"alpha-3 beta-4 nAChR"))
pmid:21787755 a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR"))
pmid:21787755 a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR"))
pmid:19126755 act(p(HBP:"alpha-3 beta-4 nAChR")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular))
pmid:19126755 complex(a(HBP:"kappa-Bungarotoxin"), p(HGNC:CHRNB4)) decreases act(p(HGNC:CHRNB4))
pmid:19126755 a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels"))
pmid:19126755 a(MESH:Conotoxins) decreases act(a(MESH:"Voltage-Gated Sodium Channels"))
pmid:19721446 a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))
pmid:19721446 a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)))
pmid:19721446 a(MESH:Conotoxins) decreases path(MESH:Pain)
pmid:19126755 p(HGNCGENEFAMILY:"Potassium voltage-gated channels") association a(CHEBI:anandamide)
pmid:19126755 a(TAXONOMY:1163) increases a(CHEBI:"Anatoxin a")
pmid:19126755 complex(a(CHEBI:"Anatoxin a"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(TAXONOMY:92736) increases a(CHEBI:epibatidine)
pmid:19293145 a(CHEBI:epibatidine) causesNoChange bp(GO:memory)
pmid:19293145 a(CHEBI:epibatidine) causesNoChange bp(GO:cognition)
pmid:19293145 a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid")
pmid:19293145 a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles")
pmid:28132910 a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384))
pmid:19126755 complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 complex(a(CHEBI:epibatidine), p(HBP:"alpha-4 beta-2 nAChR")) increases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7, loc(MESH:Muscles)))
pmid:19293145 a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7))
pmid:19293145 a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7))
pmid:19293145 a(MESH:methyllycaconitine) increases bp(MESH:Neuroprotection)
pmid:19293145 a(MESH:methyllycaconitine) decreases path(HBP:neurotoxicity)
pmid:25881725 a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide"))
pmid:25881725 a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide"))
pmid:25881725 a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide"))
pmid:25881725 a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine))
pmid:25881725 a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine))
pmid:25881725 a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine))
pmid:25881725 a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7))
pmid:25881725 a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7))
pmid:25881725 a(MESH:methyllycaconitine) decreases p(MGI:Chrna7)
pmid:25881725 a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory")
pmid:25881725 a(MESH:methyllycaconitine) causesNoChange r(MGI:Chrna7)
pmid:19721446 a(MESH:methyllycaconitine) decreases act(a(DRUGBANK:Facinicline))
pmid:19126755 complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA6)) decreases act(p(HGNC:CHRNA6, loc(MESH:Muscles)))
pmid:19126755 complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA3)) decreases act(p(HGNC:CHRNA3, loc(MESH:Muscles)))
pmid:19126755 r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family")
pmid:19126755 r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family")
pmid:21787755 r(HGNC:CHRNB4) association r(HGNC:CHRNA4)
pmid:21787755 r(HGNC:CHRNA4) association r(HGNC:CHRNB4)
pmid:21787755 r(HGNC:CHRNA6) association path(MESH:Reward)
pmid:21787755 r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions")
pmid:21787755 r(HGNC:CHRNA6) association sec(a(CHEBI:dopamine))
pmid:19126755 a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain))
pmid:19126755 path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain))
pmid:24561250 path(MESH:"Trauma, Nervous System") increases path(MESH:"Alzheimer Disease")
pmid:24561250 path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex")
pmid:19126755 a(MESH:Adult) decreases r(HGNC:CHRNA3)
pmid:19126755 a(MESH:Adult) increases r(HGNC:CHRNA4)
pmid:19126755 r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(HBP:"nAChR assembly")
pmid:19126755 act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(tscript)) increases r(HGNC:CHRNB4)
pmid:18494933 p(HGNC:JUN) partOf p(FPLX:AP1)
pmid:19126755 act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4)
pmid:19126755 p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3)
pmid:19126755 p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4)
pmid:19126755 complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) association p(HGNC:CHRNA7)
pmid:19126755 complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7)
pmid:25514383 complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases a(HBP:"alpha-7 beta-2 nAChR")
pmid:25514383 complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases surf(a(HBP:"alpha-7 beta-2 nAChR"))
pmid:19126755 complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) association p(HGNC:CHRNA7)
pmid:19126755 a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
pmid:19126755 a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction"))
pmid:19126755 a(MESH:Muscles) increases r(HGNC:CHRNA1)
pmid:19126755 a(MESH:Muscles) increases r(HGNC:CHRNB1)
pmid:19126755 a(MESH:Muscles) increases r(HGNC:CHRND)
pmid:19126755 a(MESH:Muscles) increases r(HGNC:CHRNG)
pmid:19126755 complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles)
pmid:19126755 complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface"))
pmid:23038257 complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine)
pmid:26813123 complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN)
pmid:19126755 act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation")
pmid:26813123 p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic")
pmid:19126755 complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) association a(MESH:Muscles)
pmid:19126755 complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) decreases deg(complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)))
pmid:19126755 bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE)
pmid:19126755 bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex"))
pmid:17009926 bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate")
pmid:26472524 bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate")
pmid:17009926 bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation")
pmid:19126755 r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
pmid:19126755 r(HGNC:CHRNE) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))
pmid:19126755 composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG))
pmid:19126755 complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
pmid:19126755 complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
pmid:19126755 composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG)), p(HGNC:CHRNB1)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
pmid:19126755 a(MESH:Oocytes) association composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2))
pmid:19126755 composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association a(MESH:Oocytes)
pmid:19126755 a(MESH:Hippocampus) increases p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 a(MESH:Hippocampus) increases p(HGNC:CHRNA7)
pmid:19721446 a(MESH:Hippocampus) association p(HGNC:CHRNA7)
pmid:24511233 a(MESH:Hippocampus) association bp(GO:cognition)
pmid:24511233 a(MESH:Hippocampus) association bp(GO:learning)
pmid:24511233 a(MESH:Hippocampus) association bp(GO:learning)
pmid:24511233 a(MESH:Hippocampus) association bp(GO:memory)
pmid:24511233 a(MESH:Hippocampus) association bp(GO:memory)
pmid:19721446 a(MESH:Hippocampus) association bp(GO:memory)
pmid:24511233 a(MESH:Hippocampus) association p(HGNC:CHRM4)
pmid:24590577 a(MESH:Hippocampus) association p(HGNC:CHRM1)
pmid:24590577 a(MESH:Hippocampus) association p(HGNC:CHRM2)
pmid:24590577 a(MESH:Hippocampus) association p(HGNC:CHRM3)
pmid:26390242 a(MESH:Hippocampus) positiveCorrelation a(CHEBI:salsalate)
pmid:19126755 a(MESH:Ganglia) increases p(HBP:"alpha-3 beta-2 nAChR")
pmid:19126755 a(MESH:Ganglia) increases p(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7))
pmid:19126755 g(HGNC:CHRNA7) increases p(HGNC:CHRNA7)
pmid:19126755 g(HGNC:CHRNA7) association path(MESH:"Sensory Gating")
pmid:19126755 a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(MESH:"Cell Line") regulates complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
pmid:19126755 composite(g(HGNC:CHRNA4), g(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
pmid:25514383 complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) increases a(HBP:"alpha-4 beta-2 nAChR")
pmid:19721446 complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons")
pmid:19126755 p(HGNC:CHRNA7, frag("23_46")) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7))
pmid:19126755 a(MESH:"Endoplasmic Reticulum") regulates bp(HBP:"nAChR assembly")
pmid:19126755 a(MESH:"Endoplasmic Reticulum") regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(MESH:"Endoplasmic Reticulum") increases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum")))
pmid:19126755 bp(HBP:"nAChR assembly") increases p(HBP:"alpha-3 beta-4 nAChR", loc(GO:"cell surface"))
pmid:19126755 bp(HBP:"nAChR assembly") increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface"))
pmid:19126755 a(CHEBI:"proteasome inhibitor") decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum")))
pmid:29626319 a(CHEBI:"proteasome inhibitor") increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:"proteasome inhibitor") decreases p(HGNC:MAPT)
pmid:29626319 a(CHEBI:"proteasome inhibitor") increases p(HGNC:BAG3)
pmid:21787755 a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:19126755 composite(a(CHEBI:nicotine), g(HGNC:CHRNA4), g(HGNC:CHRNA6), g(HGNC:CHRNB2), g(HGNC:CHRNB3)) increases composite(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3))
pmid:19126755 act(a(HBP:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons))
pmid:19293145 a(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease")
pmid:25514383 a(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation bp(GO:"calcium ion transport")
pmid:25514383 act(a(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis")
pmid:25514383 act(a(HBP:"alpha-4 beta-2 nAChR")) increases path(HBP:"mitochondrial dysfunction")
pmid:25514383 act(a(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress")
pmid:21482353 a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition)
pmid:21482353 a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"Dopaminergic Neurons")
pmid:21482353 a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons")
pmid:19126755 sec(a(CHEBI:"gamma-aminobutyric acid")) increases bp(GO:"hyperpolarization of postsynaptic membrane")
pmid:21482353 a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1))
pmid:21482353 a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2))
pmid:21482353 a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:19126755 bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral"))
pmid:19126755 bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway"))
pmid:26813123 bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:26813123 bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons"))
pmid:26813123 bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine)
pmid:26813123 bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine)
pmid:26813123 bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7))
pmid:28901280 bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic")
pmid:19126755 act(p(FPLX:CREB), ma(tscript)) regulates bp(GO:"gene expression")
pmid:19126755 act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity")
pmid:19126755 act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder")
pmid:27550730 act(p(FPLX:CREB)) negativeCorrelation act(p(HGNC:PDE5A))
pmid:19126755 act(complex(GO:"voltage-gated calcium channel complex")) increases bp(GO:"calcineurin-mediated signaling")
pmid:19126755 act(complex(GO:"voltage-gated calcium channel complex")) decreases act(p(FPLX:CREB), ma(tscript))
pmid:19126755 complex(GO:"voltage-gated calcium channel complex") association a(CHEBI:anandamide)
pmid:14556719 bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease")
pmid:19126755 p(HBP:"alpha-4-containing nAChR") increases sec(a(CHEBI:dopamine))
pmid:19126755 p(HBP:"alpha-6-containing nAChR") increases sec(a(CHEBI:dopamine))
pmid:19126755 bp(GO:"neuronal action potential") increases sec(a(CHEBI:dopamine))
pmid:28445721 bp(GO:"neuronal action potential") regulates p(FPLX:CHRN)
pmid:19126755 a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease")
pmid:21787755 sec(a(CHEBI:dopamine)) association r(HGNC:CHRNA6)
pmid:21787755 sec(a(CHEBI:dopamine)) association p(HGNC:CHRNA6)
pmid:28391535 a(CHEBI:dopamine) regulates path(MESH:Pleasure)
pmid:28391535 a(CHEBI:dopamine) regulates path(MESH:Motivation)
pmid:27075649 a(CHEBI:dopamine) increases a(HBP:HBP00093)
pmid:27075649 a(CHEBI:dopamine) increases a(HBP:HBP00093)
pmid:19126755 a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic")
pmid:19293145 act(a(CHEBI:"glutamate(2-)")) increases bp(HBP:Excitotoxicity)
pmid:17009926 sec(a(CHEBI:"glutamate(2-)")) increases bp(GO:"long-term synaptic potentiation")
pmid:16273023 a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047")
pmid:16273023 a(CHEBI:"glutamate(2-)") directlyIncreases act(p(MESH:D017470))
pmid:21482353 a(MESH:"Dopaminergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR")
pmid:19721446 a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3))
pmid:19721446 a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3))
pmid:19721446 a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2))
pmid:19721446 a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
pmid:19721446 a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2))
pmid:28901280 a(MESH:"Dopaminergic Neurons") regulates a(MESH:Nicotine)
pmid:14556719 a(MESH:"Dopaminergic Neurons") negativeCorrelation p(HGNC:PRKN)
pmid:19126755 a(MESH:Neuroglia) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(MESH:Keratinocytes) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:28901280 a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))
pmid:28901280 a(MESH:Keratinocytes) increases p(HGNC:CHRNA9)
pmid:19126755 a(MESH:"Endothelial Cells") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:28901280 a(MESH:"Endothelial Cells") increases a(MESH:Acetylcholine)
pmid:28901280 a(MESH:"Endothelial Cells") increases a(MESH:"Choline O-Acetyltransferase")
pmid:24027553 a(MESH:"Endothelial Cells") increases sec(a(CHEBI:Thrombin))
pmid:19126755 a(MESH:"Cholinesterase Inhibitors") causesNoChange act(p(HGNC:CHRNA7))
pmid:19293145 act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"amyloid-beta"))
pmid:19293145 act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)"))
pmid:26813123 a(MESH:"Cholinesterase Inhibitors") increases a(CHEBI:acetylcholine)
pmid:26813123 a(MESH:"Cholinesterase Inhibitors") increases bp(GO:cognition)
pmid:19126755 a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(MESH:"Neuromuscular Junction")))
pmid:19126755 a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:18986241 a(CHEBI:physostigmine) decreases path(MESH:D000544)
pmid:19126755 a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:galanthamine))
pmid:19126755 a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:physostigmine))
pmid:17009926 a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:acetylcholine))
pmid:17009926 a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:dopamine))
pmid:17009926 a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:noradrenaline))
pmid:17009926 a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:serotonin))
pmid:17009926 a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"glutamate(2-)"))
pmid:17009926 a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:17009926 a(CHEBI:"nicotinic antagonist") decreases bp(GO:memory)
pmid:19126755 a(HBP:"FK1 antibody") decreases act(a(CHEBI:galanthamine))
pmid:19126755 a(HBP:"FK1 antibody") decreases act(a(CHEBI:physostigmine))
pmid:19126755 a(HBP:"FK1 antibody") decreases a(CHEBI:codeine)
pmid:19126755 a(CHEBI:codeine) causesNoChange a(MESH:Cholinesterases)
pmid:19126755 a(CHEBI:codeine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 path(MESH:Schizophrenia) negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 path(MESH:Schizophrenia) association path(MESH:"Sensory Gating")
pmid:19126755 path(MESH:Schizophrenia) association path(MESH:"Sensory Gating")
pmid:24511233 path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders")
pmid:24511233 path(MESH:Schizophrenia) association path(MESH:"Cognitive Dysfunction")
pmid:24511233 path(MESH:Schizophrenia) association path(MESH:Hallucinations)
pmid:19721446 path(MESH:Schizophrenia) association path(MESH:Hallucinations)
pmid:24511233 path(MESH:Schizophrenia) association path(MESH:Delusions)
pmid:19721446 path(MESH:Schizophrenia) association path(MESH:Delusions)
pmid:24511233 path(MESH:Schizophrenia) association bp(GO:cognition)
pmid:19721446 path(MESH:Schizophrenia) association bp(GO:cognition)
pmid:24511233 path(MESH:Schizophrenia) association bp(GO:behavior)
pmid:24511233 path(MESH:Schizophrenia) decreases bp(GO:"synaptic transmission, cholinergic")
pmid:24511233 path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, cholinergic")
pmid:24511233 path(MESH:Schizophrenia) association path(MESH:"Memory, Short-Term")
pmid:24511233 path(MESH:Schizophrenia) association path(MESH:Attention)
pmid:24511233 path(MESH:Schizophrenia) association path(MESH:"Executive Function")
pmid:24511233 path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, glutamatergic")
pmid:24511233 path(MESH:Schizophrenia) association bp(GO:"gamma-aminobutyric acid signaling pathway")
pmid:17009926 path(MESH:Schizophrenia) association p(FPLX:CHRN)
pmid:17009926 path(MESH:Schizophrenia) association p(FPLX:CHRN)
pmid:21482353 path(MESH:Schizophrenia) association act(p(FPLX:CHRN))
pmid:11230871 path(MESH:Schizophrenia) association p(FPLX:CHRN)
pmid:21482353 path(MESH:Schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?"))
pmid:21482353 path(MESH:Schizophrenia) association bp(GO:"GABAergic neuron differentiation")
pmid:21482353 path(MESH:Schizophrenia) increases act(a(MESH:Hippocampus))
pmid:21482353 path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?"))
pmid:21482353 path(MESH:Schizophrenia) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:21482353 path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder")
pmid:21482353 path(MESH:Schizophrenia) association p(HGNC:PEMT, var("?"))
pmid:11230871 path(MESH:Schizophrenia) negativeCorrelation a(HBP:"alpha-7-containing nAChR")
pmid:11230871 path(MESH:Schizophrenia) causesNoChange a(HBP:"alpha-4-containing nAChR")
pmid:19721446 path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating")
pmid:19721446 path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7)
pmid:22040696 path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CHRNA7)
pmid:22040696 path(MESH:Schizophrenia) positiveCorrelation r(HGNC:RIC3)
pmid:19126755 path(MESH:"Sensory Gating") association g(HGNC:CHRNA7)
pmid:19126755 path(MESH:"Sensory Gating") association path(MESH:Schizophrenia)
pmid:19126755 path(MESH:"Sensory Gating") association path(MESH:Schizophrenia)
pmid:19126755 path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7))
pmid:19126755 path(HBP:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2)
pmid:30106381 path(HBP:Neurodegeneration) association p(HGNC:WFS1)
pmid:29758300 path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:18930136 path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:18930136 path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"cellular protein catabolic process")
pmid:24027553 path(HBP:Neurodegeneration) association p(MGI:Mapt, var("p.P301L"))
pmid:17403556 path(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:26631930 path(HBP:Neurodegeneration) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines"))
pmid:19126755 a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:"kynurenic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
pmid:19126755 a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:"kynurenic acid") decreases act(p(MGI:Chrna7, loc(MESH:Interneurons)))
pmid:19126755 a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity")
pmid:19126755 a(CHEBI:"kynurenic acid") regulates bp(GO:"synaptic transmission, cholinergic")
pmid:19126755 a(CHEBI:"kynurenic acid") regulates path(MESH:"Cell Survival")
pmid:19126755 a(CHEBI:"kynurenic acid") decreases a(CHEBI:dopamine, loc(GO:"extracellular region"))
pmid:19126755 a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid")
pmid:23383175 a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia)
pmid:23383175 a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath")
pmid:28803412 a(MESH:Astrocytes) increases deg(a(HBP:HBP00093))
pmid:30108137 a(MESH:Astrocytes) increases p(MGI:Tfeb)
pmid:30108137 act(a(MESH:Astrocytes)) increases a(HBP:"Tau fibrils")
pmid:26195256 act(a(MESH:Astrocytes)) decreases p(HGNC:APP)
pmid:26195256 a(MESH:Astrocytes) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid"))
pmid:18562203 act(a(MESH:Astrocytes)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
pmid:27314526 a(MESH:Astrocytes) increases p(HGNC:NLRP3)
pmid:27314526 a(MESH:Astrocytes) increases p(HGNC:TLR4)
pmid:27314526 a(MESH:Astrocytes) increases sec(p(HGNC:IL1B))
pmid:19126755 a(CHEBI:"L-kynurenine") increases a(CHEBI:"kynurenic acid")
pmid:19126755 a(MESH:Probenecid) decreases a(CHEBI:"kynurenic acid")
pmid:19126755 bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid")
pmid:19126755 act(p(HGNC:AADAT), ma(cat)) increases a(CHEBI:"kynurenic acid")
pmid:19126755 a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid")
pmid:19126755 a(CHEBI:kynurenine) increases a(CHEBI:"3-hydroxykynurenine")
pmid:19126755 a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid")
pmid:19165623 a(CHEBI:"quinolinic acid") increases a(CHEBI:"nicotinic acid")
pmid:19623258 a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP2CA)
pmid:19623258 a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP1CA)
pmid:19623258 a(CHEBI:"quinolinic acid") directlyIncreases act(complex(GO:"NMDA selective glutamate receptor complex"))
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:BRCA1)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:MYC)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:WNT1)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:WISP1)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:CDK5)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:IL1A)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:CEBPB)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:CSF2)
pmid:19623258 a(CHEBI:"quinolinic acid") increases r(HGNC:LEP)
pmid:19126755 act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons"))
pmid:19126755 p(MGI:Chrna7) negativeCorrelation path(MESH:Aging)
pmid:19293145 p(MGI:Chrna7) increases bp(MESH:"Neuronal Outgrowth")
pmid:25514383 p(MGI:Chrna7) decreases path(MESH:"Spatial Memory")
pmid:25881725 act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory")
pmid:25514383 p(MGI:Chrna7) decreases p(MGI:Syp)
pmid:25514383 p(MGI:Chrna7) decreases p(MGI:Map2)
pmid:25514383 p(MGI:Chrna7) increases p(MGI:Map2)
pmid:25514383 p(MGI:Chrna7) increases a(CHEBI:"amyloid-beta")
pmid:25514383 p(MGI:Chrna7) decreases a(CHEBI:"amyloid-beta")
pmid:25514383 p(MGI:Chrna7) increases bp(GO:cognition)
pmid:25514383 p(MGI:Chrna7) decreases path(MESH:"Cognition Disorders")
pmid:25514383 p(MGI:Chrna7) increases path(MESH:"Plaque, Amyloid")
pmid:27522251 p(MGI:Chrna7) decreases path(MESH:"Memory Disorders")
pmid:27522251 p(MGI:Chrna7) decreases path(MESH:"Memory Disorders")
pmid:27522251 p(MGI:Chrna7) decreases path(MESH:"Cognitive Dysfunction")
pmid:27522251 p(MGI:Chrna7) association bp(GO:aging)
pmid:27522251 p(MGI:Chrna7) increases a(HBP:HBP00022)
pmid:25881725 act(p(MGI:Chrna7)) increases bp(GO:learning)
pmid:25881725 p(MGI:Chrna7) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:28901280 p(MGI:Chrna7) association act(a(MESH:Epithelium))
pmid:21482353 a(MESH:"GABAergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR")
pmid:19126755 bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB))
pmid:19126755 bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1))
pmid:24760868 bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse))
pmid:28420982 bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell))
pmid:28420982 bp(MESH:"Neuronal Plasticity") association a(HBP:"Tau aggregates")
pmid:19126755 a(MESH:"Mossy Fibers, Hippocampal") increases a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells"))
pmid:19126755 a(MESH:"7-chlorothiokynurenic acid") causesNoChange a(CHEBI:dopamine, loc(GO:"extracellular region"))
pmid:19126755 a(CHEBI:anandamide) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19126755 a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(CHEBI:anandamide) association p(HGNC:CNR1)
pmid:19126755 a(CHEBI:anandamide) association p(HGNC:CNR2)
pmid:19126755 a(CHEBI:anandamide) association complex(GO:"voltage-gated calcium channel complex")
pmid:19126755 a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Potassium voltage-gated channels")
pmid:19126755 a(CHEBI:anandamide) association a(MESH:"Receptors, Serotonin")
pmid:19126755 a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits")
pmid:19126755 a(CHEBI:anandamide) decreases act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:anandamide) decreases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic")
pmid:19126755 p(HBP:"gamma-secretase") increases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:19293145 complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) decreases act(a(MESH:Bungarotoxins))
pmid:17009926 complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease")
pmid:25514383 complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Plaque, Amyloid")
pmid:19126755 p(HGNC:CNR1) association a(CHEBI:anandamide)
pmid:19126755 p(HGNC:CNR2) association a(CHEBI:anandamide)
pmid:19126755 a(MESH:"Receptors, Serotonin") association a(CHEBI:anandamide)
pmid:19126755 p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") association a(CHEBI:anandamide)
pmid:19126755 a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7))
pmid:19126755 a(CHEBI:bupropion) decreases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 a(CHEBI:bupropion) decreases act(p(HBP:"alpha-3 beta-4 nAChR"))
pmid:19126755 a(CHEBI:bupropion) association path(MESH:"Smoking Cessation")
pmid:28391535 a(CHEBI:bupropion) increases act(a(MESH:"Central Nervous System"))
pmid:28391535 a(CHEBI:bupropion) decreases path(MESH:Depression)
pmid:28391535 a(CHEBI:bupropion) decreases act(a(CHEBI:nicotine))
pmid:19126755 a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7))
pmid:19126755 a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19126755 a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-3 beta-4 nAChR"))
pmid:19126755 path(MESH:"Smoking Cessation") association a(CHEBI:bupropion)
pmid:28391535 path(MESH:"Smoking Cessation") increases path(MESH:"Irritable Mood")
pmid:28391535 path(MESH:"Smoking Cessation") increases path(MESH:Anger)
pmid:28391535 path(MESH:"Smoking Cessation") increases path(MESH:"Stress, Psychological")
pmid:28391535 path(MESH:"Smoking Cessation") increases path(MESH:Anxiety)
pmid:28391535 path(MESH:"Smoking Cessation") increases path(MESH:"Sleep Wake Disorders")
pmid:28391535 path(MESH:"Smoking Cessation") increases path(MESH:Depression)
pmid:28391535 path(MESH:"Smoking Cessation") increases path(MESH:Craving)
pmid:28391535 path(MESH:"Smoking Cessation") decreases bp(GO:cognition)
pmid:28391535 path(MESH:"Smoking Cessation") decreases path(MESH:Attention)
pmid:28391535 path(MESH:"Smoking Cessation") increases path(MESH:Appetite)
pmid:19293145 p(FPLX:PI3K) increases act(a(CHEBI:nicotine))
pmid:19293145 act(p(FPLX:PI3K)) increases act(a(MESH:"Cholinesterase Inhibitors"))
pmid:19293145 act(p(FPLX:PI3K)) increases act(p(HGNC:BAD))
pmid:19293145 p(FPLX:PI3K) increases act(a(MESH:Synapses))
pmid:19293145 act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process")
pmid:19293145 p(FPLX:PI3K) regulates act(a(CHEBI:estrogen))
pmid:22040696 act(p(FPLX:PI3K)) decreases bp(GO:"neuron death")
pmid:30116051 act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane")
pmid:26813123 p(FPLX:PKA) increases p(FPLX:CHRN, pmod(Ph))
pmid:24653673 p(FPLX:PKA) increases p(HGNC:PPP2R5A, pmod(Ph, Ser))
pmid:24653673 p(FPLX:PKA) increases p(HGNC:PPP2R5D, pmod(Ph, Ser))
pmid:12428809 p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph))
pmid:29191965 p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:22908190 act(p(FPLX:PKA)) increases p(HGNC:UCHL1)
pmid:30116051 act(p(FPLX:PKA), ma(kin)) increases p(HGNC:PSMC5, pmod(Ph, Ser, 120))
pmid:25331948 p(FPLX:PKA) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:25331948 p(FPLX:PKA) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:25331948 act(p(FPLX:PKA)) increases p(HGNC:CREB1, pmod(Ph))
pmid:26631930 p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:23001711 act(p(FPLX:PKA), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:17493042 p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 214))
pmid:17078951 p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:17078951 p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:17078951 p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:17078951 p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:17078951 p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 217))
pmid:17078951 p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17078951 p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:17078951 p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:17078951 p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:17078951 p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 212))
pmid:17078951 p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202)))
pmid:17078951 p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212)))
pmid:17078951 p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217)))
pmid:17078951 p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404)))
pmid:17078951 p(FPLX:PKA) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396)))
pmid:26692334 act(p(FPLX:PKA)) positiveCorrelation a(CHEBI:rolipram)
pmid:26692334 act(p(FPLX:PKA)) positiveCorrelation act(complex(GO:"proteasome complex"))
pmid:19721446 act(p(FPLX:"CAMK2_complex")) increases act(a(CHEBI:nicotine))
pmid:23001711 p(FPLX:"CAMK2_complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:19126755 act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity")
pmid:19126755 act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder")
pmid:19293145 act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process")
pmid:28784767 act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:28784767 act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:25001178 act(p(HGNC:MAPK1), ma(kin)) negativeCorrelation act(p(HGNC:DUSP6))
pmid:25001178 act(p(HGNC:MAPK1), ma(kin)) positiveCorrelation act(p(HGNC:CDK5), ma(kin))
pmid:19126755 path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1))
pmid:19126755 path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB))
pmid:19126755 path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing")
pmid:19126755 path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing")
pmid:19126755 path(MESH:"Tobacco Use Disorder") association path(MESH:Infection)
pmid:19126755 path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging")
pmid:19126755 path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging")
pmid:19126755 path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms)
pmid:19126755 path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative")
pmid:19126755 path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease")
pmid:19126755 path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance")
pmid:19126755 path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease")
pmid:28445721 path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN)
pmid:21482353 path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN))
pmid:21482353 path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?"))
pmid:21482353 path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?"))
pmid:21482353 path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia)
pmid:21482353 path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?"))
pmid:21482353 path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?"))
pmid:21482353 path(MESH:"Tobacco Use Disorder") increases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:21787755 path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs)
pmid:21787755 path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-4 beta-4 nAChR")
pmid:21787755 path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR")
pmid:28901280 path(MESH:"Tobacco Use Disorder") association g(DNSNP:rs1051730)
pmid:19126755 bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine))
pmid:19126755 a(MESH:Skin) association act(a(CHEBI:nicotine))
pmid:29626319 a(MESH:Skin) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(MESH:Skin) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:29626319 a(MESH:Skin) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42")
pmid:19126755 path(MESH:Infection) association path(MESH:"Tobacco Use Disorder")
pmid:19126755 path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder")
pmid:19126755 path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder")
pmid:28901280 path(MESH:Neoplasms) association p(HGNC:CHRNA7)
pmid:22020111 path(MESH:Neoplasms) negativeCorrelation p(HGNC:AIFM2)
pmid:22020111 path(MESH:Neoplasms) negativeCorrelation p(HGNC:GPX3)
pmid:23454242 path(MESH:Neoplasms) association p(FPLX:PPP2)
pmid:23454242 path(MESH:Neoplasms) negativeCorrelation act(p(FPLX:PPP2))
pmid:22299660 path(MESH:Neoplasms) association p(FPLX:PPP2)
pmid:25784053 path(MESH:Neoplasms) association act(p(HGNC:HSF1))
pmid:18930136 path(MESH:Neoplasms) negativeCorrelation bp(GO:"cellular protein catabolic process")
pmid:24563850 path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins")
pmid:24563850 path(MESH:Neoplasms) association bp(GO:"protein oxidation")
pmid:29311797 path(MESH:Neoplasms) association p(HGNC:STUB1)
pmid:22807490 path(MESH:"Colitis, Ulcerative") association path(MESH:Smoking)
pmid:23746257 bp(GO:"cell cycle") association p(FPLX:HSP90)
pmid:30126037 bp(GO:"cell cycle") association bp(GO:"cellular senescence")
pmid:19126755 path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder")
pmid:19126755 path(MESH:"Insulin Resistance") increases path(MESH:"Diabetes Mellitus, Type 1")
pmid:21718217 path(MESH:"Insulin Resistance") association p(HGNC:PPARGC1A)
pmid:19126755 path(MESH:"Genetic Variation") association act(a(CHEBI:nicotine))
pmid:19126755 a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 a(MESH:"Rats, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19126755 path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:"Neurofibrillary Tangles") biomarkerFor path(MESH:"Alzheimer Disease")
pmid:24590577 path(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease")
pmid:24027553 path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24590577 path(MESH:"Neurofibrillary Tangles") association bp(GO:"synaptic transmission, cholinergic")
pmid:24027553 path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ph))
pmid:24027553 path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ac))
pmid:24027553 path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(HBP:nitration))
pmid:24027553 path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("1_?"))
pmid:24027553 path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*"))
pmid:24027553 path(MESH:"Neurofibrillary Tangles") association a(CHEBI:Thrombin)
pmid:24027553 path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:CAPN2)
pmid:24027553 path(MESH:"Neurofibrillary Tangles") positiveCorrelation act(p(HGNCGENEFAMILY:Caspases))
pmid:24027553 path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases))
pmid:24027553 path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:MAPT, pmod(Ub))
pmid:19126755 path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19126755 p(MGI:Chrnb2) negativeCorrelation path(HBP:Neurodegeneration)
pmid:25514383 p(MGI:Chrnb2) regulates bp(MESH:Homeostasis)
pmid:25514383 p(MGI:Chrnb2) increases a(MESH:"Cerebral Cortex")
pmid:25514383 p(MGI:Chrnb2) increases path(MESH:Attention)
pmid:25514383 p(MGI:Chrnb2) increases bp(GO:cognition)
pmid:27522251 p(MGI:Chrnb2) decreases path(MESH:"Memory Disorders")
pmid:27522251 p(MGI:Chrnb2) increases a(CHEBI:"amyloid-beta")
pmid:19126755 p(MGI:Chrna4) negativeCorrelation path(MESH:Aging)
pmid:19126755 a(HBP:"amyloid-beta oligomers") regulates act(p(HGNC:CHRNA7))
pmid:19293145 a(HBP:"amyloid-beta oligomers") isA a(CHEBI:"amyloid-beta")
pmid:19293145 a(HBP:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:19293145 a(HBP:"amyloid-beta oligomers") association path(HBP:neurotoxicity)
pmid:19293145 a(HBP:"amyloid-beta oligomers") directlyIncreases path(HBP:neurotoxicity)
pmid:19293145 a(HBP:"amyloid-beta oligomers") increases act(p(FPLX:JNK))
pmid:19293145 a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:ERK))
pmid:26813123 a(HBP:"amyloid-beta oligomers") association act(a(GO:"cholinergic synapse"))
pmid:30145931 a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:Dendrites))
pmid:24760868 a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:"Post-Synaptic Density"))
pmid:24760868 a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse))
pmid:24760868 a(HBP:"amyloid-beta oligomers") increases tloc(p(HGNC:MAPT))
pmid:23528736 a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT)
pmid:30145931 a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:30145931 a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:30145931 a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:30145931 a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:24760868 a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:17403556 a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:17403556 a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:24760868 a(HBP:"amyloid-beta oligomers") increases p(HGNC:DLG4)
pmid:24760868 a(HBP:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse))
pmid:24760868 a(HBP:"amyloid-beta oligomers") increases p(HGNC:GRIA1)
pmid:24760868 a(HBP:"amyloid-beta oligomers") increases p(HGNC:FYN)
pmid:24760868 a(HBP:"amyloid-beta oligomers") decreases bp(GO:"actin filament polymerization")
pmid:24760868 a(HBP:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse))
pmid:24760868 a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:24760868 a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:24760868 a(HBP:"amyloid-beta oligomers") decreases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT))
pmid:24760868 a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:24760868 a(HBP:"amyloid-beta oligomers") regulates p(HGNC:MAPT, pmod(Ph))
pmid:22419736 a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph))
pmid:24760868 a(HBP:"amyloid-beta oligomers") causesNoChange p(HGNC:MAPT, var("p.S404A"), loc(MESH:"Dendritic Spines"))
pmid:23528736 a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:Proteasome))
pmid:22156579 act(a(HBP:"amyloid-beta oligomers")) positiveCorrelation p(INTERPRO:"Kinase associated domain 1 (KA1)")
pmid:19126755 act(p(HGNC:PTGS1)) increases a(CHEBI:"prostaglandin H2")
pmid:19126755 a(CHEBI:"NS-398") decreases p(HGNC:CHRNA4)
pmid:19126755 path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease")
pmid:19126755 path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease")
pmid:19126755 path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease")
pmid:17009926 path(MESH:"Behavior, Addictive") association p(FPLX:CHRN)
pmid:19721446 path(MESH:Craving) association p(HGNC:CHRNA3)
pmid:19721446 path(MESH:Craving) association p(HGNC:CHRNB4)
pmid:19126755 a(HBP:"beta-2-containing nAChR") association a(CHEBI:nicotine)
pmid:19126755 a(HBP:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine))
pmid:19126755 path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4)
pmid:19126755 path(MESH:"Drug Tolerance") association a(HBP:"alpha-4-containing nAChR")
pmid:19126755 a(HBP:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance")
pmid:11230871 a(HBP:"alpha-4-containing nAChR") negativeCorrelation bp(GO:aging)
pmid:11230871 a(HBP:"alpha-4-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 path(MESH:Death) association path(MESH:"Alzheimer Disease")
pmid:19293145 a(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT)
pmid:14556719 a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT)
pmid:14556719 a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT)
pmid:27574109 a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT)
pmid:22299660 a(MESH:"Neurofibrillary Tangles") association p(FPLX:PPP2C, pmod(Ph))
pmid:14556719 a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
pmid:14556719 a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
pmid:14556719 a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:27574109 a(MESH:"Neurofibrillary Tangles") association a(HBP:"Tau oligomers")
pmid:27574109 a(MESH:"Neurofibrillary Tangles") association a(HBP:"phosphatase-activating domain")
pmid:23528736 a(MESH:"Neurofibrillary Tangles") association p(HBP:"UBB+1")
pmid:19293145 a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease")
pmid:16273023 a(CHEBI:"NMDA receptor antagonist") association bp(GO:"GO:0035249")
pmid:16273023 a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474))
pmid:21882945 a(CHEBI:"NMDA receptor antagonist") positiveCorrelation bp(GO:cognition)
pmid:19293145 composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:19293145 a(HBP:"amyloid-beta fibrils") isA a(CHEBI:"amyloid-beta")
pmid:17403556 a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph))
pmid:17403556 a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:17403556 a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:17403556 a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:19293145 a(HBP:"Abeta*56") decreases path(MESH:"Maze Learning")
pmid:19293145 p(HGNC:BCHE) decreases a(CHEBI:acetylcholine)
pmid:18986241 act(p(HGNC:BCHE), ma(cat)) directlyIncreases deg(a(CHEBI:acetylcholine))
pmid:18986241 p(HGNC:BCHE) association a(MESH:D016874)
pmid:18986241 p(HGNC:BCHE) association path(MESH:D058225)
pmid:18986241 p(HGNC:BCHE) association path(MESH:D003071)
pmid:19293145 g(HGNC:CHAT) association path(MESH:"Alzheimer Disease")
pmid:19293145 g(HGNC:ACHE) association path(MESH:"Alzheimer Disease")
pmid:19293145 a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine))
pmid:19293145 a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine))
pmid:19293145 a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:19293145 a(CHEBI:"dihydro-beta-erythroidine") decreases bp(MESH:Neuroprotection)
pmid:17009926 a(CHEBI:"dihydro-beta-erythroidine") decreases act(p(HGNC:CHRNB2))
pmid:17009926 a(CHEBI:"dihydro-beta-erythroidine") decreases bp(GO:memory)
pmid:19293145 a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine))
pmid:28391535 a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine))
pmid:17009926 a(CHEBI:Mecamylamine) isA a(CHEBI:"nicotinic antagonist")
pmid:17009926 a(CHEBI:Mecamylamine) decreases path(MESH:Attention)
pmid:26813123 a(CHEBI:Mecamylamine) decreases act(a(MESH:"Hypothalamo-Hypophyseal System"))
pmid:11230871 a(CHEBI:Mecamylamine) decreases bp(GO:cognition)
pmid:19721446 a(CHEBI:Mecamylamine) decreases bp(GO:cognition)
pmid:28391535 a(CHEBI:Mecamylamine) decreases path(MESH:Hypertension)
pmid:28391535 a(CHEBI:Mecamylamine) increases path(MESH:Tremor)
pmid:28391535 a(CHEBI:Mecamylamine) increases path(MESH:Confusion)
pmid:28391535 a(CHEBI:Mecamylamine) increases path(MESH:Seizures)
pmid:28391535 a(CHEBI:Mecamylamine) increases path(MESH:"Bipolar Disorder")
pmid:28391535 a(CHEBI:Mecamylamine) increases path(MESH:Depression)
pmid:28391535 a(CHEBI:Mecamylamine) decreases path(MESH:Smoking)
pmid:28391535 a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic"))
pmid:28391535 a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic"))
pmid:23038257 bp(GO:"intracellular receptor signaling pathway") association p(HGNC:CHRNA4)
pmid:19293145 a(MESH:Bungarotoxins) decreases act(a(CHEBI:"amyloid-beta"))
pmid:19293145 a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))
pmid:19293145 act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:23038257 a(MESH:Bungarotoxins) decreases bp(GO:"neuromuscular synaptic transmission")
pmid:23038257 a(MESH:Bungarotoxins) decreases act(a(MESH:"Electric Organ"))
pmid:23038257 a(MESH:Bungarotoxins) decreases act(a(CHEBI:decamethonium))
pmid:25514383 a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28445721 a(MESH:Bungarotoxins) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:19293145 composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) regulates act(a(CHEBI:nicotine))
pmid:19293145 act(a(CHEBI:ethanol)) increases path(HBP:neurotoxicity)
pmid:19293145 a(MESH:Serum) decreases bp(GO:"cell death")
pmid:24027553 bp(HBP:Excitotoxicity) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular))
pmid:24183963 a(CHEBI:glucose) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:24183963 a(CHEBI:glucose) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:16630055 a(CHEBI:glucose) negativeCorrelation path(MESH:Fasting)
pmid:19293145 a(CHEBI:thapsigargin) increases bp(GO:"cell death")
pmid:19293145 a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport")
pmid:29024336 a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress")
pmid:19293145 act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity)
pmid:19293145 act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity)
pmid:19293145 a(CHEBI:"N-methyl-4-phenylpyridinium") increases path(HBP:neurotoxicity)
pmid:19293145 act(a(CHEBI:methamphetamine)) increases bp(HBP:Neurodegeneration)
pmid:26813123 bp(HBP:Neurodegeneration) negativeCorrelation bp(GO:memory)
pmid:26813123 bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, glutamatergic")
pmid:26813123 bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, cholinergic")
pmid:18986241 bp(HBP:Neurodegeneration) association path(MESH:D060825)
pmid:19293145 act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7))
pmid:19293145 act(p(HGNC:FAS)) increases bp(GO:"programmed cell death")
pmid:23702978 act(p(HGNC:FAS)) increases act(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:FAS)) increases act(p(HGNC:CASP8))
pmid:19293145 bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine)
pmid:19293145 p(FPLX:SRC) increases act(a(CHEBI:nicotine))
pmid:17009926 act(p(FPLX:SRC), ma(kin)) increases p(HGNC:CHRNA7, pmod(Ph))
pmid:22040696 act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr))
pmid:22040696 act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr))
pmid:25514383 p(FPLX:AKT, pmod(Ph)) decreases bp(GO:"apoptotic process")
pmid:19293145 a(MESH:"Nicotinic Antagonists") decreases bp(MESH:Neuroprotection)
pmid:19293145 p(HGNC:FYN) association p(HGNC:MAPT, pmod(Ph))
pmid:18680553 p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph))
pmid:19293145 p(HGNC:FYN) increases bp(GO:cognition)
pmid:19293145 p(HGNC:FYN) increases act(p(FPLX:PI3K))
pmid:19293145 p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(Ph))
pmid:19293145 p(HGNC:FYN) decreases bp(GO:"apoptotic process")
pmid:19293145 p(HGNC:FYN) association bp(MESH:Neuroprotection)
pmid:19293145 p(HGNC:FYN) increases bp(MESH:Neuroprotection)
pmid:19293145 p(HGNC:FYN) association act(a(CHEBI:"amyloid-beta"))
pmid:19293145 p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:PTK2))
pmid:19293145 p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph))
pmid:19293145 p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph))
pmid:24760868 p(HGNC:FYN, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:30640040 p(HGNC:FYN) association a(PUBCHEM:4878)
pmid:29191965 p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))
pmid:26751493 p(HGNC:FYN) association p(HBP:"projection domain")
pmid:26631930 p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:17493042 p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:26631930 p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(Ph))
pmid:18680553 p(HGNC:FYN) association p(HGNC:MAPT)
pmid:18680553 p(HGNC:FYN) association p(HGNC:MAPT, frag("223_226"))
pmid:18680553 p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:MAPT))
pmid:26751493 p(HGNC:FYN) association a(HBP:"projection domain")
pmid:19293145 complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT))
pmid:19293145 p(MGI:Fyn) decreases bp(MESH:Neuroprotection)
pmid:18096814 p(MGI:Fyn) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid")
pmid:18096814 p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft"))
pmid:25125464 p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine")
pmid:25125464 act(p(MGI:Fyn)) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472))
pmid:25125464 act(p(MGI:Fyn)) increases p(HBP:"Tau epitope, AT8")
pmid:19293145 p(HGNC:JAK2) increases bp(MESH:Neuroprotection)
pmid:19293145 p(HGNC:JAK2) association bp(MESH:Neuroprotection)
pmid:19293145 p(HGNC:JAK2) increases act(a(CHEBI:nicotine))
pmid:19293145 act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine))
pmid:19293145 p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 p(HGNC:JAK2) association act(p(HGNC:STAT3))
pmid:19293145 p(HGNC:JAK2) increases act(p(HGNC:FYN))
pmid:19293145 complex(p(HGNC:FYN), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 complex(p(HGNC:FYN), p(HGNC:MAPT)) regulates path(HBP:Excitotoxicity)
pmid:18680553 complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation bp(GO:myelination)
pmid:19293145 p(HGNC:MAPT, pmod(Ph, Tyr)) association p(HGNC:PTK2, pmod(Ph))
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Tyr)) increases a(HBP:"Tau aggregates")
pmid:19293145 p(HGNC:PTK2, pmod(Ph)) association p(HGNC:MAPT, pmod(Ph, Tyr))
pmid:19293145 p(HGNC:PTK2, pmod(Ph)) decreases act(p(HGNC:PTK2))
pmid:19293145 p(HGNC:CHRNA7, pmod(Ph)) decreases act(a(CHEBI:acetylcholine))
pmid:23038257 p(HGNC:CHRNA7, pmod(Ph)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization))
pmid:17009926 p(HGNC:CHRNA7, pmod(Ph)) decreases act(p(HGNC:CHRNA7))
pmid:19293145 a(CHEBI:estradiol) decreases act(a(CHEBI:"amyloid-beta"))
pmid:19293145 a(CHEBI:estradiol) decreases path(HBP:neurotoxicity)
pmid:19293145 act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine))
pmid:19293145 act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)"))
pmid:19293145 composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS))
pmid:19293145 act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease")
pmid:19293145 g(HGNC:NIN) association g(HGNC:GSK3B)
pmid:19293145 g(HGNC:GSK3B) association g(HGNC:NIN)
pmid:19293145 act(p(HGNC:MYC)) increases bp(GO:"apoptotic process")
pmid:19293145 complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade")
pmid:19293145 complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK))
pmid:19293145 complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade")
pmid:19293145 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK1, pmod(Ph))
pmid:19293145 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK3, pmod(Ph))
pmid:19293145 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK14, pmod(Ph))
pmid:19293145 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK8, pmod(Ph))
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:cognition)
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:"Memory, Episodic")
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection)
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival")
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating")
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating")
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases act(p(HGNC:CHRNA7))
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:memory)
pmid:19721446 a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention)
pmid:18494933 p(HGNC:MAPK8, pmod(Ph)) increases act(p(HGNC:MAPK8))
pmid:23528736 p(HGNC:MAPK8) increases bp(GO:autophagy)
pmid:23528736 p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(Ph))
pmid:23528736 p(HGNC:MAPK8) increases p(HGNC:BCL2L11, pmod(Ph))
pmid:18494933 act(p(HGNC:MAPK8)) increases p(HGNC:JUN)
pmid:11943212 p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:19293145 a(MESH:"A-582941") increases p(HGNC:MAPK3, pmod(Ph))
pmid:19293145 a(MESH:"A-582941") increases p(HGNC:MAPK1, pmod(Ph))
pmid:19293145 a(CHEBI:"SL-327") decreases act(a(MESH:"A-582941"))
pmid:19293145 act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide")
pmid:19293145 composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade")
pmid:19293145 composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)")
pmid:19293145 composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1))
pmid:19293145 composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(Ph))
pmid:19293145 composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases sec(a(CHEBI:dopamine))
pmid:19293145 composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine))
pmid:19293145 act(p(FPLX:RAS)) increases p(HGNC:STAT3)
pmid:18986241 p(FPLX:RAS) association bp(GO:"GO:0014065")
pmid:18986241 p(FPLX:RAS) association bp(GO:"GO:0043491")
pmid:19293145 composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(Ph))
pmid:19293145 act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(HBP:neurotoxicity)
pmid:19293145 bp(GO:"calcium-mediated signaling") association act(a(CHEBI:"amyloid-beta"))
pmid:19293145 bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection)
pmid:19293145 bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7))
pmid:19293145 bp(GO:"calcium-mediated signaling") association a(CHEBI:nicotine)
pmid:19293145 bp(GO:"calcium-mediated signaling") association composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:23746257 bp(GO:"calcium-mediated signaling") association p(FPLX:HSP90)
pmid:25514383 bp(GO:"calcium ion transport") negativeCorrelation a(HBP:"alpha-4 beta-2 nAChR")
pmid:25514383 bp(GO:"calcium ion transport") positiveCorrelation a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:21482353 bp(GO:"calcium ion transport") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:19293145 a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7))
pmid:19721446 a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") association path(MESH:"Attention Deficit Disorder with Hyperactivity")
pmid:19293145 a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole"))
pmid:19293145 p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") association a(CHEBI:nicotine)
pmid:19293145 act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)")
pmid:19293145 p(HGNCGENEFAMILY:"Ryanodine receptors") association a(CHEBI:nicotine)
pmid:19293145 act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis")
pmid:19293145 composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) increases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits", pmod(Ph))
pmid:19293145 bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease")
pmid:19293145 composite(a(CHEBI:"amyloid-beta"), complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2))) increases bp(GO:"cellular calcium ion homeostasis")
pmid:19293145 composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:"calcium-mediated signaling")
pmid:19293145 composite(p(HGNC:MAPK14), p(HGNC:MAPK8)) decreases bp(GO:"long-term synaptic potentiation")
pmid:19293145 g(HGNC:APOE) increases p(HGNC:APOE)
pmid:19293145 g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT)
pmid:19293145 g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine))
pmid:19293145 g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
pmid:19293145 bp(GO:"lipid metabolic process") association p(HGNC:APOE)
pmid:19293145 bp(GO:"lipid metabolic process") association p(HGNC:CHRNA4)
pmid:19293145 p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7))
pmid:19293145 act(a(CHEBI:carbachol)) decreases a(CHEBI:phosphatidylinositol)
pmid:24590577 a(CHEBI:carbachol) increases act(p(HGNC:CHRM1))
pmid:26751493 a(CHEBI:phosphatidylinositol) association p(HBP:"projection domain")
pmid:26751493 a(CHEBI:phosphatidylinositol) association a(HBP:"projection domain")
pmid:19293145 p(HBP:"APOE e4") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis))
pmid:26195256 p(HBP:"APOE e4") association path(MESH:"Alzheimer Disease")
pmid:26195256 p(HBP:"APOE e4") regulates a(MESH:"Blood-Brain Barrier")
pmid:26195256 p(HBP:"APOE e4") decreases bp(HBP:"perivascular drainage pathways")
pmid:27087442 p(HBP:"APOE e4") increases p(MGI:Cdk5)
pmid:27087442 p(HBP:"APOE e4") increases p(HBP:"CDK5R1 p25")
pmid:27087442 p(HBP:"APOE e4") increases p(MGI:Cdk5r1)
pmid:27087442 p(HBP:"APOE e4") increases p(MGI:Capn1)
pmid:27087442 p(HBP:"APOE e4") increases p(MGI:Capn2)
pmid:27087442 p(HBP:"APOE e4") causesNoChange p(MGI:Gsk3b)
pmid:28720530 p(HBP:"APOE e4") directlyDecreases p(HGNC:PPP2R5E)
pmid:28720530 p(HBP:"APOE e4") negativeCorrelation complex(GO:"protein phosphatase type 2A complex")
pmid:19293145 a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen))
pmid:30145931 a(CHEBI:wortmannin) decreases bp(GO:autophagy)
pmid:30145931 a(CHEBI:wortmannin) increases p(HGNC:MAPT)
pmid:30145931 a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:30145931 a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:30145931 a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:30145931 a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:30145931 a(CHEBI:wortmannin) decreases a(MESH:"Dendritic Spines")
pmid:19293145 composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases sec(a(CHEBI:"amyloid-beta"))
pmid:19293145 composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP)
pmid:22040696 complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7))
pmid:19293145 complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases path(HBP:neurotoxicity)
pmid:19293145 complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7))
pmid:18986241 complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases r(HGNC:CHRNA7)
pmid:18986241 complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases bp(GO:"GO:0007271")
pmid:22040696 complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"neuron death")
pmid:19293145 composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory)
pmid:19293145 composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph))
pmid:19293145 composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph))
pmid:19293145 complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process")
pmid:19293145 bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT)
pmid:24653673 bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307))
pmid:24653673 bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307))
pmid:29191965 bp(GO:"insulin receptor signaling pathway") positiveCorrelation composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")))
pmid:19293145 bp(GO:"choline transport") association a(CHEBI:"amyloid-beta")
pmid:19293145 complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))
pmid:19293145 complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))
pmid:19293145 complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7))
pmid:25514383 a(CHEBI:methyllycaconitine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 a(CHEBI:methyllycaconitine) decreases bp(HP:Neurodegeneration)
pmid:19293145 p(HGNC:APP, frag("25_35")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19293145 p(HGNC:APP, frag("25_35")) increases act(p(HGNC:CHRNA7))
pmid:19721446 complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons")
pmid:21482353 p(HGNC:CHRNA7, var("?")) positiveCorrelation path(MESH:Schizophrenia)
pmid:18986241 r(HGNC:CHRNA7) negativeCorrelation path(MESH:D003071)
pmid:18986241 r(HGNC:CHRNA7) regulates act(a(MESH:D059329))
pmid:18986241 r(HGNC:CHRNA7) increases path(MESH:D009410)
pmid:11230871 r(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19293145 composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) increases r(MGI:Chrna7)
pmid:19293145 composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) causesNoChange r(MGI:Chrna4)
pmid:23038257 a(CHEBI:"4-(trimethylammonium)benzenediazonium") decreases act(a(MESH:"Electric Organ"))
pmid:23038257 a(MESH:Curare) decreases act(a(CHEBI:"4-(trimethylammonium)benzenediazonium"))
pmid:23038257 a(CHEBI:"4-(N-Maleimido)phenyltrimethylammonium iodide") increases act(a(MESH:"Affinity Labels"))
pmid:23038257 a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic"))
pmid:26813123 a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System"))
pmid:26813123 act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission")
pmid:26813123 a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26813123 act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse))
pmid:26813123 act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(Ph))
pmid:19721446 a(MESH:"Receptors, Nicotinic") regulates sec(a(CHEBI:serotonin))
pmid:23038257 a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic"))
pmid:23038257 a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
pmid:23038257 a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D)
pmid:28901280 p(MESH:"Receptors, Nicotinic") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors")
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:Learning)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:Memory)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:Arousal)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:Reward)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association bp(MESH:Analgesia)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation")
pmid:28901280 p(MESH:"Receptors, Nicotinic") association bp(HBP:"cell population proliferation")
pmid:28901280 p(MESH:"Receptors, Nicotinic") association bp(GO:"cell differentiation")
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:"Cognition Disorders")
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:Anxiety)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:Depression)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:"Alzheimer Disease")
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:"Parkinson Disease")
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:Pain)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association path(MESH:Epilepsy)
pmid:28901280 p(MESH:"Receptors, Nicotinic") association a(MESH:Neurons)
pmid:28901280 p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) association a(HBP:neurotransmitters)
pmid:28901280 p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) association a(HBP:neurotransmitters)
pmid:23038257 p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine)
pmid:23038257 a(CHEBI:"zinc(2+)") increases act(p(MESH:"Receptors, Nicotinic"))
pmid:19721446 a(CHEBI:"zinc(2+)") decreases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:2833519 a(CHEBI:"zinc(2+)") increases act(p(HGNC:S100B))
pmid:23038257 a(MESH:Galantamine) regulates act(p(MESH:"Receptors, Nicotinic"))
pmid:23038257 a(MESH:Ivermectin) increases act(p(HGNC:CHRNA7))
pmid:23038257 p(HGNC:SCNN1D, var("?")) regulates act(a(MESH:Ivermectin))
pmid:23038257 a(MESH:Anesthetics) decreases p(MESH:"Receptors, Nicotinic")
pmid:23038257 a(MESH:Anesthetics) increases p(MESH:"Receptors, GABA")
pmid:19721446 a(MESH:Anesthetics) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:23038257 p(MESH:Agrin) increases p(HGNC:RAPSN, pmod(Ph, Tyr))
pmid:23038257 p(HGNC:RAPSN, pmod(Ph, Tyr)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization))
pmid:22040696 p(HGNC:RAPSN) increases bp(GO:"skeletal muscle acetylcholine-gated channel clustering")
pmid:23038257 p(MESH:"Receptors, Nicotinic", pmod(Ph)) increases act(p(MESH:Agrin))
pmid:23038257 p(MESH:"Cytoskeletal Proteins") association p(HGNC:CHRNA4)
pmid:24511233 path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease")
pmid:24511233 path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia)
pmid:24590577 path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4)
pmid:22040696 path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(chap))
pmid:24511233 path(MESH:Hallucinations) association path(MESH:Schizophrenia)
pmid:24511233 path(MESH:Hallucinations) biomarkerFor path(MESH:Schizophrenia)
pmid:19721446 path(MESH:Hallucinations) association path(MESH:Schizophrenia)
pmid:24511233 path(MESH:Delusions) association path(MESH:Schizophrenia)
pmid:24511233 path(MESH:Delusions) biomarkerFor path(MESH:Schizophrenia)
pmid:19721446 path(MESH:Delusions) association path(MESH:Schizophrenia)
pmid:24511233 p(HGNC:CHRM1) association bp(GO:cognition)
pmid:24511233 act(p(HGNC:CHRM1)) increases bp(GO:cognition)
pmid:24590577 act(p(HGNC:CHRM1)) increases bp(GO:cognition)
pmid:24511233 p(HGNC:CHRM1) decreases act(a(CHEBI:amphetamine))
pmid:24511233 p(HGNC:CHRM1) decreases bp(GO:"dopamine secretion, neurotransmission")
pmid:24511233 p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
pmid:24511233 act(p(HGNC:CHRM1)) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
pmid:24511233 p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation")
pmid:24511233 act(p(HGNC:CHRM1)) increases a(CHEBI:acetylcholine)
pmid:24511233 act(p(HGNC:CHRM1)) increases deg(a(HBP:"sAPP-alpha"))
pmid:24590577 act(p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha")
pmid:26813123 act(p(HGNC:CHRM1)) association a(MESH:"Cholinergic Neurons")
pmid:26813123 act(p(HGNC:CHRM1)) association path(MESH:"Cognitive Dysfunction")
pmid:26813123 act(p(HGNC:CHRM1)) association act(p(HGNC:MAPT))
pmid:26813123 act(p(HGNC:CHRM1)) association act(a(CHEBI:"amyloid-beta"))
pmid:24590577 act(p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta")
pmid:26813123 act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:26813123 act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC))
pmid:24590577 act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC))
pmid:24590577 act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC))
pmid:24590577 act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC))
pmid:26813123 act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B))
pmid:24590577 act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B))
pmid:24590577 p(HGNC:CHRM1) association a(MESH:Hippocampus)
pmid:24590577 p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex")
pmid:24590577 p(HGNC:CHRM1) association a(MESH:"Corpus Striatum")
pmid:24590577 p(HGNC:CHRM1) association a(MESH:Thalamus)
pmid:24590577 p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity")
pmid:24590577 p(HGNC:CHRM1) association bp(GO:learning)
pmid:24590577 p(HGNC:CHRM1) association bp(GO:memory)
pmid:24590577 p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction")
pmid:24590577 p(HGNC:CHRM1) association bp(GO:"neuron differentiation")
pmid:24590577 p(HGNC:CHRM1) regulates bp(GO:"synaptic transmission, glutamatergic")
pmid:24590577 act(p(HGNC:CHRM1)) increases bp(GO:"ERK1 and ERK2 cascade")
pmid:24590577 act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade")
pmid:24590577 act(p(HGNC:CHRM1)) increases p(HGNC:BACE1)
pmid:24590577 p(HGNC:CHRM1) regulates p(HGNC:BACE1)
pmid:24590577 act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade")
pmid:24590577 act(p(HGNC:CHRM1)) increases bp(HBP:neurotoxicity)
pmid:24590577 act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway")
pmid:24590577 act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24590577 act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage")
pmid:24590577 act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress")
pmid:24590577 act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases))
pmid:24590577 act(p(HGNC:CHRM1)) decreases bp(GO:"cell death")
pmid:18986241 p(HGNC:CHRM1) association path(MESH:D060825)
pmid:18986241 p(HGNC:CHRM1) association path(MESH:D024801)
pmid:18986241 p(HGNC:CHRM1) association path(MESH:D000686)
pmid:26813123 p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26813123 act(p(HGNC:CHRM2)) increases a(CHEBI:"amyloid-beta")
pmid:24590577 p(HGNC:CHRM2) association a(MESH:Hippocampus)
pmid:24590577 p(HGNC:CHRM2) association a(MESH:Neocortex)
pmid:24590577 p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine))
pmid:24590577 p(HGNC:CHRM3) association a(MESH:Hypothalamus)
pmid:24590577 p(HGNC:CHRM3) association a(MESH:Hippocampus)
pmid:24511233 p(HGNC:CHRM4) association path(MESH:"Avoidance Learning")
pmid:24511233 p(HGNC:CHRM4) association a(MESH:Hippocampus)
pmid:24511233 p(HGNC:CHRM4) association a(MESH:"Corpus Striatum")
pmid:24590577 p(HGNC:CHRM4) association a(MESH:"Corpus Striatum")
pmid:24511233 p(HGNC:CHRM4) association a(MESH:Neocortex)
pmid:24511233 p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic")
pmid:24511233 act(p(HGNC:CHRM4)) decreases bp(GO:"synaptic transmission, glutamatergic")
pmid:24590577 p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders")
pmid:24590577 p(HGNC:CHRM4) association path(MESH:"Parkinson Disease")
pmid:24590577 p(HGNC:CHRM4) decreases act(p(HGNC:DRD1))
pmid:24590577 p(HGNC:CHRM5) association a(MESH:"Pars Compacta")
pmid:24590577 p(HGNC:CHRM5) increases bp(GO:"response to drug")
pmid:24590577 p(HGNC:CHRM5) increases act(a(CHEBI:morphine))
pmid:24590577 p(HGNC:CHRM5) increases act(a(CHEBI:cocaine))
pmid:24511233 complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport")
pmid:24511233 complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate")
pmid:26088141 p(HGNC:GNAQ) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ))
pmid:24511233 complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport")
pmid:24511233 complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate")
pmid:24511233 complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport")
pmid:24511233 complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate")
pmid:24511233 complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP")
pmid:26088141 p(HGNC:GNAI1) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI1))
pmid:24511233 complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP")
pmid:17009926 path(MESH:Depression) association p(FPLX:CHRN)
pmid:11230871 path(MESH:Depression) association p(FPLX:CHRN)
pmid:26813123 path(MESH:Depression) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21482353 path(MESH:Depression) association bp(GO:"synaptic transmission, cholinergic")
pmid:19721446 path(MESH:Depression) increases a(CHEBI:choline)
pmid:28901280 path(MESH:Depression) association p(MESH:"Receptors, Nicotinic")
pmid:27314526 bp(HBP:neuroinflammation) association sec(a(MESH:Interleukins))
pmid:24511233 a(MESH:"Muscarinic Antagonists") decreases bp(GO:cognition)
pmid:24511233 a(MESH:"Muscarinic Antagonists") increases path(MESH:"Cognitive Dysfunction")
pmid:24511233 a(MESH:"Muscarinic Antagonists") association path(MESH:"Mental Processes")
pmid:24511233 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic")
pmid:24511233 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:cognition)
pmid:24511233 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases path(MESH:"Mental Processes")
pmid:24511233 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Cardiovascular System")
pmid:24511233 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Gastrointestinal Tract")
pmid:17009926 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease")
pmid:17009926 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases act(p(HGNC:ACHE))
pmid:17009926 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline)))
pmid:17009926 a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases act(p(FPLX:CHRN))
pmid:24511233 path(MESH:"Mental Processes") association a(MESH:"Muscarinic Antagonists")
pmid:24511233 a(MESH:"Cardiovascular System") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")
pmid:24590577 a(MESH:"Cardiovascular System") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:24511233 a(MESH:"Gastrointestinal Tract") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")
pmid:24511233 a(MESH:"Gastrointestinal Tract") association a(CHEBI:xanomeline)
pmid:24590577 a(MESH:"Gastrointestinal Tract") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:29626319 a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:29626319 a(MESH:"Gastrointestinal Tract") causesNoChange a(CHEBI:"amyloid-beta polypeptide 42")
pmid:24511233 path(MESH:Anhedonia) biomarkerFor path(MESH:Schizophrenia)
pmid:24511233 path(MESH:"Social Isolation") biomarkerFor path(MESH:Schizophrenia)
pmid:24511233 path(MESH:"Memory, Short-Term") association path(MESH:Schizophrenia)
pmid:24511233 path(MESH:Attention) association path(MESH:Schizophrenia)
pmid:17009926 path(MESH:Attention) association p(FPLX:CHRN)
pmid:26813123 path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic")
pmid:24590577 path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:25514383 path(MESH:Attention) association a(HP:"cholinergic neuron")
pmid:24511233 path(MESH:"Executive Function") association path(MESH:Schizophrenia)
pmid:24511233 a(CHEBI:"antipsychotic agent") regulates p(HGNC:DRD2)
pmid:24511233 a(CHEBI:"antipsychotic agent") causesNoChange bp(GO:cognition)
pmid:24511233 bp(GO:"gamma-aminobutyric acid signaling pathway") association path(MESH:Schizophrenia)
pmid:24511233 a(CHEBI:xanomeline) increases bp(GO:cognition)
pmid:26813123 a(CHEBI:xanomeline) increases bp(GO:cognition)
pmid:24590577 a(CHEBI:xanomeline) increases bp(GO:cognition)
pmid:24511233 a(CHEBI:xanomeline) decreases path(MESH:Hallucinations)
pmid:26813123 a(CHEBI:xanomeline) decreases path(MESH:Hallucinations)
pmid:24511233 a(CHEBI:xanomeline) decreases path(MESH:Delusions)
pmid:24511233 a(CHEBI:xanomeline) decreases path(MESH:Schizophrenia)
pmid:24511233 a(CHEBI:xanomeline) increases bp(GO:learning)
pmid:24511233 a(CHEBI:xanomeline) increases path(MESH:"Memory, Short-Term")
pmid:24511233 a(CHEBI:xanomeline) association a(MESH:"Gastrointestinal Tract")
pmid:26813123 a(CHEBI:xanomeline) increases bp(GO:memory)
pmid:24590577 a(CHEBI:xanomeline) increases bp(GO:memory)
pmid:26813123 a(CHEBI:xanomeline) decreases path(MESH:"Mood Disorders")
pmid:26813123 a(CHEBI:xanomeline) decreases path(MESH:"Psychomotor Agitation")
pmid:24590577 a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders")
pmid:24590577 a(CHEBI:xanomeline) increases act(p(HGNC:CHRM1))
pmid:24590577 a(CHEBI:xanomeline) increases act(p(HGNC:CHRM4))
pmid:24511233 act(a(CHEBI:amphetamine)) increases bp(GO:locomotion)
pmid:24511233 p(MGI:Chrm1) decreases act(a(CHEBI:"amyloid-beta"))
pmid:24590577 p(MGI:Chrm1) increases bp(GO:cognition)
pmid:24590577 p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation")
pmid:24590577 act(p(MGI:Chrm1)) decreases bp(HBP:"APP processing")
pmid:24590577 act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid")
pmid:18986241 act(p(MGI:Chrm1)) increases act(p(MGI:Adam17))
pmid:24511233 a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases act(p(HGNC:CHRM1))
pmid:24590577 a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases bp(GO:cognition)
pmid:24590577 a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") association a(MESH:"Antipsychotic Agents")
pmid:24511233 a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1))
pmid:24590577 a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1))
pmid:24590577 a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(a(MESH:"Pyramidal Cells"))
pmid:24511233 a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1))
pmid:24590577 a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1))
pmid:24511233 a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases act(a(CHEBI:scopolamine))
pmid:24511233 a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta")
pmid:24590577 a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta")
pmid:24590577 a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases bp(GO:"NMDA selective glutamate receptor signaling pathway")
pmid:24511233 act(a(CHEBI:scopolamine)) decreases bp(GO:"behavioral fear response")
pmid:24511233 a(MESH:VU0357017) increases complex(a(MESH:VU0357017), p(HGNC:CHRM1))
pmid:24511233 a(MESH:VU0357017) decreases act(a(CHEBI:scopolamine))
pmid:24511233 a(MESH:VU0357017) increases bp(GO:"behavioral fear response")
pmid:24590577 a(MESH:VU0357017) increases act(p(HGNC:CHRM1))
pmid:24590577 a(MESH:VU0357017) decreases path(MESH:"Cognitive Dysfunction")
pmid:24590577 a(MESH:VU0357017) increases bp(GO:learning)
pmid:24511233 complex(a(MESH:VU0357017), p(HGNC:CHRM1)) increases act(p(HGNC:CHRM1))
pmid:24511233 complex(a(MESH:"GSK 1034702"), p(HGNC:CHRM1)) increases bp(GO:cognition)
pmid:24511233 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases act(p(HGNC:CHRM1))
pmid:24511233 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential")
pmid:24511233 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine))
pmid:24511233 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response")
pmid:24511233 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning)
pmid:24590577 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning)
pmid:24511233 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:memory)
pmid:24590577 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1))
pmid:24590577 a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(HBP:"APP processing")
pmid:24511233 a(MESH:"Prefrontal Cortex") association bp(GO:cognition)
pmid:24511233 a(MESH:"Prefrontal Cortex") association bp(GO:learning)
pmid:24511233 a(MESH:"Prefrontal Cortex") association bp(GO:memory)
pmid:26195256 a(MESH:"Prefrontal Cortex") association path(MESH:"Alzheimer Disease")
pmid:24511233 a(MESH:"VU 0405652") increases act(p(HGNC:CHRM1))
pmid:24511233 a(HBP:VU0456940) increases act(p(HGNC:CHRM1))
pmid:24511233 a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases act(a(CHEBI:apomorphine))
pmid:24511233 a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases path(MESH:"Avoidance Learning")
pmid:24511233 act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition")
pmid:24511233 act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition")
pmid:24511233 path(MESH:"Avoidance Learning") association p(HGNC:CHRM4)
pmid:24511233 a(MESH:"Corpus Striatum") association p(HGNC:CHRM4)
pmid:24590577 a(MESH:"Corpus Striatum") association p(HGNC:CHRM4)
pmid:24590577 a(MESH:"Corpus Striatum") association p(HGNC:CHRM1)
pmid:24762290 a(MESH:"Corpus Striatum") association complex(HBP:"alpha-4 beta-2 nAChR")
pmid:24511233 a(MESH:Neocortex) association p(HGNC:CHRM4)
pmid:24590577 a(MESH:Neocortex) association p(HGNC:CHRM2)
pmid:24511233 a(HBP:VU10010) increases act(a(CHEBI:acetylcholine))
pmid:24511233 a(HBP:VU10010) increases act(p(HGNC:CHRM4))
pmid:24511233 a(HBP:VU0152099) decreases act(a(CHEBI:amphetamine))
pmid:29191965 bp(GO:locomotion) positiveCorrelation a(CHEBI:"methylene blue")
pmid:29191965 bp(GO:locomotion) positiveCorrelation a(PUBCHEM:6475963)
pmid:29191965 bp(GO:locomotion) positiveCorrelation a(HBP:"Phenylthiazolyl-hydrazide")
pmid:24511233 a(MESH:"3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide") decreases act(a(CHEBI:amphetamine))
pmid:28445721 bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN)
pmid:21787755 bp(GO:"neurotransmitter secretion") association a(HBP:"alpha-7-containing nAChR")
pmid:17009926 bp(GO:"developmental process") association p(FPLX:CHRN)
pmid:17009926 path(MESH:Epilepsy) association p(FPLX:CHRN)
pmid:17009926 path(MESH:Epilepsy) association p(FPLX:CHRN)
pmid:11230871 path(MESH:Epilepsy) association p(FPLX:CHRN)
pmid:21482353 path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNA4, var("?"))
pmid:21482353 path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNB2, var("?"))
pmid:21787755 path(MESH:Epilepsy) association a(HBP:AβOs)
pmid:28901280 path(MESH:Epilepsy) association p(MESH:"Receptors, Nicotinic")
pmid:17009926 path(MESH:"Autistic Disorder") association p(FPLX:CHRN)
pmid:17009926 path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN))
pmid:17009926 path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN)
pmid:30106381 path(MESH:"Autistic Disorder") association p(HGNC:ADNP)
pmid:30106381 path(MESH:"Autistic Disorder") association a(PUBCHEM:9832404)
pmid:26472524 tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization")
pmid:17009926 p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:17009926 p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:17009926 p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:17009926 p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:17009926 composite(a(CHEBI:acetylcholine), a(CHEBI:ivermectin)) increases act(p(FPLX:CHRN))
pmid:17009926 a(CHEBI:ivermectin) regulates act(p(HGNC:CHRNA7))
pmid:17009926 composite(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), a(CHEBI:ivermectin)) increases act(p(HGNC:CHRNA7))
pmid:17009926 composite(a(CHEBI:"5-hydroxyindole"), a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRNA7))
pmid:17009926 a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") regulates act(p(HGNC:CHRNA7))
pmid:28132910 a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(GO:membrane), a(PUBCHEM:16068384))
pmid:28132910 a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384))
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:acetylcholine))
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:dopamine))
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:noradrenaline))
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:serotonin))
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"glutamate(2-)"))
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory)
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory)
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:learning)
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention)
pmid:17009926 a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:cognition)
pmid:19323834 a(CHEBI:noradrenaline) increases p(HGNC:SUMO1)
pmid:17009926 a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex"))
pmid:17009926 bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN)
pmid:17009926 act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization")
pmid:17009926 bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN)
pmid:17009926 bp(GO:"action potential") increases sec(a(CHEBI:dopamine))
pmid:17009926 path(MESH:"Lewy Body Disease") negativeCorrelation act(p(FPLX:CHRN))
pmid:17009926 path(MESH:"Lewy Body Disease") negativeCorrelation p(FPLX:CHRN)
pmid:27075649 path(MESH:"Lewy Body Disease") positiveCorrelation a(HBP:HBP00016)
pmid:17009926 bp(GO:"response to pain") association p(FPLX:CHRN)
pmid:17009926 a(PUBCHEM:5311278) decreases act(p(HGNC:CHRNA7))
pmid:17009926 a(PUBCHEM:5311278) decreases bp(GO:memory)
pmid:25514383 a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:26813123 p(FPLX:CHRM) isA a(MESH:"Receptors, G-Protein-Coupled")
pmid:26813123 p(FPLX:CHRM) regulates a(MESH:"Ion Channels")
pmid:26813123 p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels"))
pmid:26813123 p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels"))
pmid:26813123 act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels"))
pmid:26813123 p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels"))
pmid:26813123 act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic")
pmid:25514383 p(FPLX:CHRM) regulates bp(GO:cognition)
pmid:17009926 p(HGNC:CHRNA4, var("p.Ser248Thr")) increases path(MESH:Epilepsy)
pmid:17009926 g(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy")
pmid:17009926 path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNA4, var("?"))
pmid:17009926 path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNB2, var("?"))
pmid:17009926 g(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy")
pmid:28445721 path(MESH:Arousal) association p(FPLX:CHRN)
pmid:28901280 path(MESH:Arousal) association p(MESH:"Receptors, Nicotinic")
pmid:23702978 a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly")
pmid:23702978 a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:23702978 a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:23702978 a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD))
pmid:23702978 a(CHEBI:"potassium(1+)") decreases sec(p(HGNC:IL1B))
pmid:24561250 a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex"))
pmid:26472524 act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation")
pmid:26751493 p(MESH:"Receptors, N-Methyl-D-Aspartate") association a(HBP:"projection domain")
pmid:16820021 a(HBP:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol")
pmid:16820021 a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1))
pmid:16820021 a(MESH:antalarmin) increases p(RGD:Drd2)
pmid:16820021 a(MESH:antalarmin) decreases p(RGD:Drd2)
pmid:16820021 a(MESH:antalarmin) increases p(RGD:Drd3)
pmid:16820021 a(MESH:antalarmin) decreases p(RGD:Drd3)
pmid:16820021 a(MESH:antalarmin) decreases path(HBP:"isolation rearing")
pmid:16820021 a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing")
pmid:16820021 a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing")
pmid:16820021 a(MESH:antalarmin) causesNoChange r(RGD:Bdnf)
pmid:16820021 a(MESH:antalarmin) decreases r(RGD:Ntrk2)
pmid:16820021 a(MESH:antalarmin) increases r(RGD:Ntrk2)
pmid:29807032 a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response")
pmid:29807032 a(MESH:antalarmin) increases act(p(NCBIGENE:140621))
pmid:29807032 a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures")
pmid:23211705 a(MESH:antalarmin) increases a(MESH:"Embryonic Structures")
pmid:23211705 a(MESH:antalarmin) increases a(MESH:Morula)
pmid:23211705 a(MESH:antalarmin) increases a(MESH:Blastocyst)
pmid:23211705 a(MESH:antalarmin) decreases act(p(MGI:Crh))
pmid:23211705 a(MESH:antalarmin) decreases act(p(MGI:Crh))
pmid:23211705 a(MESH:antalarmin) decreases act(p(MGI:Crh))
pmid:23211705 a(MESH:antalarmin) decreases act(p(MGI:Crh))
pmid:23211705 a(MESH:antalarmin) regulates p(MGI:Crh)
pmid:16820021 path(HBP:"isolation rearing") increases p(RGD:Drd2)
pmid:16820021 path(HBP:"isolation rearing") increases p(RGD:Drd2)
pmid:16820021 path(HBP:"isolation rearing") increases p(RGD:Drd3)
pmid:16820021 path(HBP:"isolation rearing") increases p(RGD:Drd3)
pmid:16820021 path(HBP:"isolation rearing") decreases r(RGD:Bdnf)
pmid:16820021 path(HBP:"isolation rearing") increases r(RGD:Bdnf)
pmid:16820021 path(HBP:"isolation rearing") decreases r(RGD:Ntrk2)
pmid:16820021 path(HBP:"isolation rearing") increases r(RGD:Ntrk2)
pmid:11230871 a(CHEBI:neurotransmitter) association bp(GO:cognition)
pmid:14556719 sec(a(CHEBI:neurotransmitter)) association p(HGNC:SYT11, pmod(Ub))
pmid:26813123 bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain"))
pmid:24563850 bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins")
pmid:24563850 bp(GO:"response to stress") increases p(HGNC:HSF1, pmod(Ph))
pmid:24563850 bp(GO:"response to stress") increases p(HGNC:HSF1, loc(MESH:"Cell Nucleus"))
pmid:24563850 bp(GO:"response to stress") increases act(p(HGNC:HSF1), ma(tscript))
pmid:26813123 bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") association bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 bp(GO:"regulation of circadian sleep/wake cycle, sleep") association bp(GO:"synaptic transmission, cholinergic")
pmid:26813123 bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic")
pmid:21482353 bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic")
pmid:24590577 bp(GO:"circadian sleep/wake cycle") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:26813123 p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles"))
pmid:26813123 p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles"))
pmid:26813123 p(HGNC:SLC18A3) increases tloc(a(CHEBI:proton), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:cytosol))
pmid:26813123 p(HGNC:CHAT, pmod(Ph)) regulates act(p(HGNC:CHAT))
pmid:26813123 a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases act(p(HGNC:SLC18A3))
pmid:26813123 a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles"))
pmid:26813123 p(MGI:Slc18a3) decreases path(MESH:"Neuromuscular Diseases")
pmid:26813123 p(MGI:Slc18a3) increases bp(GO:cognition)
pmid:26813123 a(CHEBI:"organophosphorus compound") decreases act(p(HGNC:ACHE))
pmid:26813123 a(CHEBI:antidote) increases act(p(HGNC:ACHE))
pmid:26813123 a(CHEBI:doxylamine) increases act(p(HGNC:ACHE))
pmid:26813123 a(CHEBI:succinylcholine) decreases act(p(HGNC:ACHE))
pmid:26813123 p(MGI:Slc5a7) decreases path(MESH:Death)
pmid:26813123 complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation")
pmid:26813123 a(MESH:"Basal Nucleus of Meynert") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26813123 p(FPLX:CHRN, pmod(Ph)) regulates act(p(FPLX:CHRN))
pmid:26813123 a(MESH:"Protein-Tyrosine Kinases") increases p(FPLX:CHRN, pmod(Ph))
pmid:26813123 complex(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN))
pmid:26813123 complex(a(CHEBI:cystine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN))
pmid:22020111 a(CHEBI:cystine) increases a(CHEBI:glutathione)
pmid:26813123 complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN))
pmid:11230871 complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition)
pmid:26813123 a(CHEBI:tubocurarine) decreases act(p(FPLX:CHRN))
pmid:29626319 a(MESH:"Receptors, G-Protein-Coupled") increases deg(a(CHEBI:"amyloid-beta"))
pmid:26813123 complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC))
pmid:26813123 complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol")
pmid:26813123 complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels"))
pmid:26813123 complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate")
pmid:26813123 complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26813123 complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition)
pmid:26813123 complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC))
pmid:26813123 complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol")
pmid:26813123 complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels"))
pmid:26813123 complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate")
pmid:26813123 complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC))
pmid:26813123 complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol")
pmid:26813123 complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels"))
pmid:26813123 complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate")
pmid:26813123 complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY)
pmid:26813123 complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP")
pmid:26813123 complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels"))
pmid:26813123 complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY)
pmid:26813123 complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP")
pmid:26813123 complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels"))
pmid:26088141 act(a(MESH:"Calcium Channels")) association act(a(CHEBI:choline))
pmid:26088141 act(a(MESH:"Calcium Channels")) association a(CHEBI:"calcium(2+)")
pmid:26813123 complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM))
pmid:26813123 a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM))
pmid:26813123 a(MESH:"Receptors, Cholinergic") increases bp(GO:memory)
pmid:25514383 a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention)
pmid:26813123 path(MESH:Apathy) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26813123 p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:24590577 p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine))
pmid:24590577 p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm")
pmid:24590577 p(MGI:Chrm4) decreases act(p(MGI:Drd1))
pmid:26813123 path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(MESH:"Cholinergic Neurons")
pmid:22020111 path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(HBP:"protein aggregates")
pmid:12428809 path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(MESH:"Intermediate Filaments")
pmid:29758300 path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding))
pmid:29758300 path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:macroautophagy)
pmid:14556719 path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem")
pmid:14556719 path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:"spinal cord development")
pmid:14556719 path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts")
pmid:14556719 path(MESH:"Amyotrophic Lateral Sclerosis") increases path(MESH:Paralysis)
pmid:14556719 path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:"neuron death")
pmid:14556719 path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?"))
pmid:14556719 path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A)
pmid:14556719 path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:UBL5)
pmid:22908190 path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub))
pmid:22908190 path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub))
pmid:25784053 path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:autophagy)
pmid:25784053 path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6)
pmid:30116051 path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1)
pmid:30116051 path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHMP2B)
pmid:30116051 path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1)
pmid:30116051 path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN)
pmid:26813123 path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation a(MESH:"Cholinergic Neurons")
pmid:29758300 path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT)
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT)
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") increases a(HBP:HBP00045)
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle")
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration)
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis)
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders")
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders")
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies)
pmid:29311797 path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies)
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction")
pmid:30126037 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:CDKN2A)
pmid:29191965 path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, var("p.Ala152Thr"))
pmid:26631930 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr"))
pmid:28420982 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers")
pmid:26631930 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers")
pmid:26751493 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau")
pmid:26631930 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau")
pmid:26631930 path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation g(HGNC:MIR132)
pmid:26631930 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:SRSF2)
pmid:26631930 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:12578227 path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1)
pmid:12578227 path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1)
pmid:12578227 path(MESH:"Supranuclear Palsy, Progressive") increases r(HBP:"TGM2 Isoform 3 (349 aa)")
pmid:12578227 path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2)
pmid:11089576 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:"2.3.2.13"))
pmid:22057784 path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197))
pmid:17050703 path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:29281045 path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1)
pmid:29281045 path(MESH:"Supranuclear Palsy, Progressive") increases p(ECCODE:"3.1.1.89")
pmid:26813123 path(MESH:"Olivopontocerebellar Atrophies") negativeCorrelation a(MESH:"Cholinergic Neurons")
pmid:26813123 act(a(GO:"cholinergic synapse")) association a(HBP:"amyloid-beta oligomers")
pmid:26813123 complex(a(MESH:"Amyloid beta-Peptides"), p(HGNC:ACHE)) increases a(HBP:"amyloid-beta fibrils")
pmid:26813123 p(MGI:App, var("?")) decreases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:26813123 p(MGI:App, var("?")) decreases p(FPLX:CHRM)
pmid:26813123 p(MGI:App, var("?")) decreases p(FPLX:CHRN)
pmid:26813123 a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1))
pmid:26813123 a(PUBCHEM:10013505) increases bp(GO:cognition)
pmid:26813123 a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:26813123 a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?"))
pmid:26813123 a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases")
pmid:24653673 p(HGNC:MAPT, var("?")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT))
pmid:30116051 p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex"))
pmid:30116051 p(HGNC:MAPT, var("?")) decreases bp(GO:"chaperone-mediated autophagy")
pmid:29215007 p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29988016 p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates")
pmid:21882945 p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates")
pmid:21882945 p(HGNC:MAPT, var("?")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("?")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines"))
pmid:26631930 p(HGNC:MAPT, var("?")) decreases act(a(GO:synapse))
pmid:26813123 a(PUBCHEM:9867750) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:26813123 a(PUBCHEM:9867750) increases act(p(HGNC:CHRM1))
pmid:26813123 a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic"))
pmid:26813123 a(PUBCHEM:9867750) increases bp(GO:cognition)
pmid:26813123 a(PUBCHEM:1476756) increases bp(GO:"excitatory postsynaptic potential")
pmid:26813123 a(PUBCHEM:1476756) increases bp(GO:memory)
pmid:24027553 a(HBP:Excitotoxicity) association act(p(HGNCGENEFAMILY:Calpains))
pmid:25899010 a(HBP:Excitotoxicity) positiveCorrelation p(HGNC:DAPK1)
pmid:26813123 a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons")
pmid:26813123 a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons")
pmid:26813123 a(MESH:"Nerve Growth Factor") increases bp(GO:memory)
pmid:11230871 a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN))
pmid:16273023 path(MESH:D000544) association path(MESH:D016874)
pmid:18986241 path(MESH:D000544) increases path(MESH:D016874)
pmid:16273023 path(MESH:D000544) association path(MESH:D058225)
pmid:16273023 path(MESH:D000544) association bp(GO:"GO:0070997")
pmid:16273023 path(MESH:D000544) decreases bp(MESH:D009435)
pmid:16273023 path(MESH:D000544) decreases bp(GO:"GO:0007271")
pmid:16273023 path(MESH:D000544) decreases bp(GO:"GO:0035249")
pmid:16273023 path(MESH:D000544) decreases act(p(HGNC:CHAT), ma(cat))
pmid:18986241 path(MESH:D000544) decreases p(HGNC:CHAT)
pmid:16273023 path(MESH:D000544) decreases bp(GO:"GO:0015871")
pmid:16273023 path(MESH:D000544) decreases bp(GO:"GO:0008292")
pmid:16273023 path(MESH:D000544) causesNoChange p(MESH:D011950)
pmid:16273023 path(MESH:D000544) decreases bp(GO:"GO:0051935")
pmid:16273023 path(MESH:D000544) decreases bp(GO:"GO:0014047")
pmid:16273023 path(MESH:D000544) decreases bp(GO:"GO:0014047")
pmid:16273023 path(MESH:D000544) decreases bp(MESH:D017774)
pmid:16273023 path(MESH:D000544) decreases bp(MESH:D017774)
pmid:16273023 path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
pmid:18986241 path(MESH:D000544) association path(MESH:D019636)
pmid:18986241 path(MESH:D000544) association path(MESH:D008568)
pmid:18986241 path(MESH:D000544) association path(MESH:D003071)
pmid:18986241 path(MESH:D000544) association path(MESH:D001526)
pmid:18986241 path(MESH:D000544) association path(HBP:aMCI)
pmid:18986241 path(MESH:D000544) decreases a(MESH:D059329)
pmid:18986241 path(MESH:D000544) association a(MESH:D059329)
pmid:18986241 path(MESH:D000544) decreases a(MESH:D059329)
pmid:18986241 path(MESH:D000544) association a(MESH:D016874)
pmid:18986241 path(MESH:D000544) decreases p(HGNC:ACHE)
pmid:18986241 path(MESH:D000544) causesNoChange act(p(HGNC:ACHE))
pmid:18986241 path(MESH:D000544) decreases act(p(HGNC:ACHE))
pmid:18986241 path(MESH:D000544) decreases act(p(HGNC:ACHE))
pmid:18986241 path(MESH:D000544) increases act(p(HGNC:BCHE))
pmid:18986241 path(MESH:D000544) causesNoChange p(HGNC:SLC18A3)
pmid:18986241 path(MESH:D000544) increases path(MESH:D001284)
pmid:18986241 path(MESH:D000544) decreases p(HGNC:NTRK1)
pmid:18986241 path(MESH:D000544) increases p(HGNC:NGF)
pmid:18986241 path(MESH:D000544) association p(HGNC:SORT1)
pmid:18986241 path(MESH:D000544) decreases bp(GO:"GO:0032455")
pmid:18986241 path(MESH:D000544) increases act(p(HGNC:MMP9))
pmid:18986241 path(MESH:D000544) decreases g(HGNC:NTRK1)
pmid:18986241 path(MESH:D000544) decreases g(HGNC:NTRK2)
pmid:18986241 path(MESH:D000544) decreases g(HGNC:NTRK3)
pmid:18986241 path(MESH:D000544) increases g(HGNC:NGFR)
pmid:18986241 path(MESH:D000544) causesNoChange r(HGNC:CHAT)
pmid:18986241 path(MESH:D000544) increases r(HGNC:CHRNA7)
pmid:18986241 path(MESH:D000544) increases r(HGNC:CHRNA7)
pmid:18986241 path(MESH:D000544) causesNoChange r(HGNC:CHRM1)
pmid:18986241 path(MESH:D000544) decreases r(HGNC:SYP)
pmid:18986241 path(MESH:D000544) causesNoChange r(HGNC:VAMP1)
pmid:18986241 path(MESH:D000544) causesNoChange r(HGNC:SNAP29)
pmid:18986241 path(MESH:D000544) causesNoChange r(HGNC:APP)
pmid:18986241 path(MESH:D000544) causesNoChange r(HGNC:NOTCH1)
pmid:18986241 path(MESH:D000544) increases r(HGNC:CTSD)
pmid:18986241 path(MESH:D000544) decreases r(HGNC:PPP1CA)
pmid:18986241 path(MESH:D000544) decreases r(HGNC:PPP1CC)
pmid:18986241 path(MESH:D000544) causesNoChange r(HGNC:MAPT)
pmid:18986241 path(MESH:D000544) decreases a(HBP:"3R tau")
pmid:16273023 path(MESH:D016874) association path(MESH:D000544)
pmid:18986241 path(MESH:D016874) association bp(HBP:hyperphosphorylation)
pmid:16273023 path(MESH:D058225) association path(MESH:D000544)
pmid:18986241 path(MESH:D058225) association p(HGNC:BCHE)
pmid:18986241 path(MESH:D058225) association p(HGNC:ACHE)
pmid:16273023 bp(GO:"GO:0070997") association path(MESH:D000544)
pmid:16273023 bp(GO:"GO:0070997") association act(p(MESH:D017470))
pmid:16273023 bp(GO:"GO:0007271") association path(MESH:D003071)
pmid:16273023 bp(GO:"GO:0007271") association path(MESH:D003071)
pmid:16273023 bp(GO:"GO:0007271") association a(MESH:D002800)
pmid:16273023 bp(GO:"GO:0035249") association path(MESH:D003071)
pmid:16273023 bp(GO:"GO:0035249") association path(MESH:D003071)
pmid:16273023 bp(GO:"GO:0035249") increases bp(GO:"GO:0051935")
pmid:16273023 bp(GO:"GO:0035249") association a(CHEBI:"NMDA receptor antagonist")
pmid:16273023 path(MESH:D003071) association bp(GO:"GO:0035249")
pmid:16273023 path(MESH:D003071) association bp(GO:"GO:0035249")
pmid:16273023 path(MESH:D003071) association bp(GO:"GO:0007271")
pmid:16273023 path(MESH:D003071) association bp(GO:"GO:0007271")
pmid:18986241 path(MESH:D003071) association path(MESH:D000544)
pmid:18986241 path(MESH:D003071) association p(HGNC:BCHE)
pmid:18986241 path(MESH:D003071) association g(HGNC:NTRK1)
pmid:18986241 path(MESH:D003071) association g(HGNC:NTRK2)
pmid:18986241 path(MESH:D003071) association g(HGNC:NTRK3)
pmid:18986241 path(MESH:D003071) negativeCorrelation r(HGNC:CHRNA7)
pmid:18986241 path(MESH:D003071) association act(p(HGNC:GAL))
pmid:16273023 bp(GO:"GO:0008292") association path(MESH:D003704)
pmid:16273023 path(MESH:D003704) association bp(GO:"GO:0008292")
pmid:18986241 path(MESH:D003704) association path(HBP:aMCI)
pmid:18986241 path(MESH:D003704) association a(MESH:D059329)
pmid:18986241 path(MESH:D003704) decreases p(HGNC:ACHE)
pmid:16273023 path(MESH:D013850) association a(MESH:D006624)
pmid:16273023 path(MESH:D013850) association a(MESH:D019579)
pmid:16273023 path(MESH:D013850) association a(CHEBI:"glutamate(1-)")
pmid:16273023 a(MESH:D006624) association path(MESH:D013850)
pmid:16273023 a(MESH:D006624) association path(MESH:D008568)
pmid:16273023 a(MESH:D019579) association path(MESH:D013850)
pmid:16273023 a(MESH:D019579) association path(MESH:D008568)
pmid:16273023 path(MESH:D008568) association a(MESH:D006624)
pmid:16273023 path(MESH:D008568) association a(MESH:D019579)
pmid:16273023 path(MESH:D008568) association a(CHEBI:"glutamate(1-)")
pmid:16273023 path(MESH:D008568) association bp(MESH:D017774)
pmid:18986241 path(MESH:D008568) association path(MESH:D000544)
pmid:18986241 path(MESH:D008568) association a(MESH:D059329)
pmid:16273023 act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)")
pmid:16273023 bp(GO:"GO:0014047") increases bp(GO:"GO:0035249")
pmid:16273023 bp(GO:"GO:0014047") increases bp(MESH:D017774)
pmid:16273023 bp(GO:"GO:0051935") increases a(CHEBI:glutamine)
pmid:16273023 a(CHEBI:glutamine) increases bp(GO:"GO:0006868")
pmid:16273023 act(p(MESH:D017470)) association bp(GO:"GO:0070997")
pmid:16273023 bp(MESH:D017774) association path(MESH:D008568)
pmid:16273023 bp(MESH:D017774) association path(MESH:D007858)
pmid:16273023 path(MESH:D007858) association bp(MESH:D017774)
pmid:16273023 a(MESH:D017966) association composite(p(MESH:D011950), p(MESH:D017470))
pmid:16273023 composite(p(MESH:D011950), p(MESH:D017470)) association a(MESH:D017966)
pmid:16273023 a(MESH:D002800) increases bp(GO:"GO:0014047")
pmid:16273023 a(MESH:D002800) increases bp(GO:"GO:0014047")
pmid:16273023 a(MESH:D002800) increases a(CHEBI:acetylcholine)
pmid:16273023 a(MESH:D002800) association bp(GO:"GO:0007271")
pmid:18986241 a(MESH:D002800) decreases path(MESH:D000544)
pmid:18986241 a(MESH:D002800) decreases a(CHEBI:"amyloid-beta")
pmid:18986241 a(MESH:D002800) increases bp(MESH:D000066829)
pmid:18986241 a(MESH:D002800) association bp(GO:"GO:0050435")
pmid:18986241 a(MESH:D002800) association path(MESH:D007319)
pmid:18986241 a(MESH:D002800) association path(MESH:D003967)
pmid:18986241 a(MESH:D002800) association path(MESH:D009325)
pmid:18986241 a(MESH:D002800) association path(MESH:D005221)
pmid:18986241 a(MESH:D002800) association path(MESH:D000855)
pmid:16273023 complex(a(CHEBI:acetylcholine), p(MESH:D011950)) increases a(CHEBI:acetylcholine)
pmid:16273023 a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
pmid:24590577 a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles")
pmid:24027553 a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles")
pmid:28083634 a(HBP:"Tau aggregates") negativeCorrelation p(HGNC:OTUB1)
pmid:29758300 a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:23528736 a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:29758300 a(HBP:"Tau aggregates") association bp(GO:autophagy)
pmid:29758300 a(HBP:"Tau aggregates") association complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT))
pmid:22908190 a(HBP:"Tau aggregates") increases p(HBP:"Tau aggregates", pmod(Ub))
pmid:22908190 a(HBP:"Tau aggregates") decreases act(complex(GO:"proteasome complex"))
pmid:24027553 a(HBP:"Tau aggregates") positiveCorrelation path(HBP:neurotoxicity)
pmid:24027553 a(HBP:"Tau aggregates") decreases act(p(HGNCGENEFAMILY:Proteasome))
pmid:24027553 a(HBP:"Tau aggregates") positiveCorrelation a(MESH:Autophagosomes)
pmid:27574109 a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal transport")
pmid:29590627 a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body"))
pmid:29590627 a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body"))
pmid:29590627 a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body"))
pmid:26751493 a(HBP:"Tau aggregates") positiveCorrelation tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons))
pmid:26751493 tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(HBP:"Tau aggregates")
pmid:29590627 a(HBP:"Tau aggregates") association a(GO:"early endosome")
pmid:29590627 a(HBP:"Tau aggregates") association a(GO:"late endosome")
pmid:29590627 a(HBP:"Tau aggregates") association a(GO:lysosome)
pmid:22611162 a(HBP:"Tau aggregates") increases path(HBP:proteotoxicity)
pmid:22611162 a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport")
pmid:26631930 a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport")
pmid:22611162 a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling")
pmid:22611162 a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling")
pmid:22611162 a(HBP:"Tau aggregates") decreases bp(GO:"maintenance of synapse structure")
pmid:22611162 a(HBP:"Tau aggregates") decreases p(UNIPROT:O02495)
pmid:22611162 a(HBP:"Tau aggregates") decreases bp(GO:"intracellular distribution of mitochondria")
pmid:22611162 a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport of mitochondrion")
pmid:28528849 a(HBP:"Tau aggregates") causesNoChange bp(GO:"cell death")
pmid:28528849 a(HBP:"Tau aggregates") causesNoChange a(GO:membrane)
pmid:29988016 a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27373205 a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22817713 a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21882945 a(HBP:"Tau aggregates") increases path(MESH:Tauopathies)
pmid:29311797 a(HBP:"Tau aggregates") increases path(MESH:Tauopathies)
pmid:30640040 a(HBP:"Tau aggregates") increases bp(GO:"cell killing")
pmid:29191965 a(HBP:"Tau aggregates") decreases act(a(GO:synapse))
pmid:29191965 a(HBP:"Tau aggregates") decreases a(GO:presynapse)
pmid:29191965 a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:25374103 a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle")
pmid:28420982 a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle")
pmid:28877763 a(HBP:"Tau aggregates") association p(HGNC:SYK)
pmid:28877763 a(HBP:"Tau aggregates") association p(HGNC:SYK)
pmid:28877763 a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:SYK)
pmid:28877763 a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:28420982 a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport")
pmid:22817713 a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport")
pmid:22817713 a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport")
pmid:22817713 a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport")
pmid:28420982 a(HBP:"Tau aggregates") association bp(MESH:"Neuronal Plasticity")
pmid:28420982 a(HBP:"Tau aggregates") association sec(p(HGNC:MAPT))
pmid:28420982 a(HBP:"Tau aggregates") association a(CHEBI:dextran)
pmid:29311797 a(HBP:"Tau aggregates") association p(HGNC:HDAC6)
pmid:29311797 a(HBP:"Tau aggregates") association bp(GO:"glucocorticoid receptor signaling pathway")
pmid:26631930 a(HBP:"Tau aggregates") negativeCorrelation complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 a(HBP:"Tau aggregates") positiveCorrelation bp(GO:aging)
pmid:26631930 a(HBP:"Tau aggregates") decreases bp(GO:"microtubule polymerization")
pmid:26631930 a(HBP:"Tau aggregates") decreases act(a(MESH:Neurons))
pmid:26631930 a(HBP:"Tau aggregates") increases path(HBP:Neurodegeneration)
pmid:22817713 a(HBP:"Tau aggregates") increases act(p(HGNC:PPP1CA))
pmid:22817713 a(HBP:"Tau aggregates") increases act(p(HGNC:GSK3A))
pmid:22817713 a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:22817713 a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:25125464 a(HBP:"Tau aggregates") positiveCorrelation p(MGI:Crhr1)
pmid:12428809 bp(GO:"axonal transport") association p(HGNC:MAPT)
pmid:12428809 bp(GO:"axonal transport") association p(HGNC:APP)
pmid:12428809 bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:12428809 bp(GO:"axonal transport") association a(CHEBI:"amyloid-beta")
pmid:12428809 bp(GO:"axonal transport") association p(HGNC:GSK3B)
pmid:26631930 bp(GO:"axonal transport") decreases path(HBP:Neurodegeneration)
pmid:21734277 bp(GO:"axonal transport") negativeCorrelation act(p(HGNC:PPP1CA))
pmid:24590577 complex(a(CHEBI:acetylcholine), p(FPLX:"G_protein"), p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) increases bp(GO:"synaptic transmission, cholinergic")
pmid:24590577 complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC))
pmid:24590577 complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport")
pmid:24590577 complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC))
pmid:24590577 complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport")
pmid:24590577 complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC))
pmid:24590577 complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport")
pmid:24590577 complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases")
pmid:24590577 complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP")
pmid:24590577 complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases")
pmid:24590577 complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP")
pmid:24590577 path(MESH:Nociception) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:24590577 a(MESH:Kidney) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
pmid:29626319 a(MESH:Kidney) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:29626319 a(MESH:Kidney) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42")
pmid:24590577 a(MESH:Thalamus) association p(HGNC:CHRM1)
pmid:24762290 a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR")
pmid:24762290 a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR")
pmid:24590577 p(MGI:Chrm2) decreases path(MESH:"Nociceptive Pain")
pmid:24590577 a(MESH:Hypothalamus) association p(HGNC:CHRM3)
pmid:24590577 p(MGI:Chrm3) regulates bp(GO:"response to food")
pmid:24590577 p(MGI:Chrm3) increases bp(GO:"pituitary gland development")
pmid:24590577 p(MGI:Chrm3) increases p(MGI:Prl)
pmid:24590577 p(MGI:Chrm3) increases p(MGI:Gh)
pmid:24590577 p(MGI:Chrm3) increases bp(GO:"multicellular organism growth")
pmid:24590577 a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease")
pmid:24590577 a(MESH:"Pars Compacta") association p(HGNC:CHRM5)
pmid:22020111 a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11))
pmid:24590577 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1)
pmid:24590577 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta")
pmid:24590577 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph))
pmid:24590577 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph))
pmid:24590577 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Plaque, Amyloid")
pmid:24590577 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:memory)
pmid:24590577 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:learning)
pmid:24590577 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:24401760 p(MGI:Bace1) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:24590577 complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1))
pmid:29686391 bp(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau oligomers")
pmid:24590577 bp(GO:"Wnt signaling pathway") decreases bp(HBP:neurotoxicity)
pmid:23454242 bp(GO:"Wnt signaling pathway") association p(FPLX:PPP2)
pmid:18494933 bp(GO:"Wnt signaling pathway") negativeCorrelation act(p(HGNC:GSK3B))
pmid:24590577 a(MESH:cevimeline) increases act(p(HGNC:CHRM1))
pmid:24027553 act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNCGENEFAMILY:Caspases)) positiveCorrelation path(MESH:"Neurofibrillary Tangles")
pmid:24027553 act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles")
pmid:24027553 act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:Inflammation)
pmid:24027553 act(p(HGNCGENEFAMILY:Caspases)) increases a(HBP:"Tau aggregates")
pmid:24590577 a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases act(p(MGI:Chrm1))
pmid:24590577 a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases bp(GO:memory)
pmid:24590577 a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases path(MESH:"Executive Function")
pmid:24590577 complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha")
pmid:24590577 complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta")
pmid:24590577 complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction")
pmid:24590577 a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:24590577 a(CHEBI:cevimeline) decreases path(MESH:"Sjogren's Syndrome")
pmid:24590577 a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta")
pmid:24590577 a(CHEBI:cevimeline) causesNoChange a(HBP:"sAPP-alpha")
pmid:24590577 a(CHEBI:cevimeline) increases path(MESH:Confusion)
pmid:24590577 a(CHEBI:cevimeline) increases path(MESH:Diarrhea)
pmid:24590577 a(CHEBI:cevimeline) increases path(MESH:Asthenia)
pmid:24590577 a(CHEBI:cevimeline) increases path(MESH:"Gastrointestinal Diseases")
pmid:24590577 a(MESH:"talsaclidine fumarate") increases a(HBP:"sAPP-alpha")
pmid:24590577 a(MESH:"talsaclidine fumarate") decreases a(CHEBI:"amyloid-beta")
pmid:24590577 a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating)
pmid:24590577 a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation)
pmid:24590577 a(MESH:"WAY 132983") increases bp(GO:cognition)
pmid:24590577 a(MESH:"WAY 132983") increases path(MESH:Salivation)
pmid:24590577 a(MESH:"WAY 132983") increases path(MESH:Hypothermia)
pmid:24590577 a(HBP:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1))
pmid:24590577 a(HBP:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1))
pmid:24590577 a(MESH:"Antipsychotic Agents") association a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one")
pmid:24590577 a(HBP:VU0184670) increases act(p(HGNC:CHRM1))
pmid:24590577 a(HBP:VU0184670) increases bp(GO:"NMDA selective glutamate receptor signaling pathway")
pmid:26088141 p(HGNC:GNAS) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAS))
pmid:26088141 p(HGNC:GNAI2) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI2))
pmid:26088141 p(HGNCGENEFAMILY:"G protein subunits beta") increases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7))
pmid:26088141 composite(p(HBP:"alpha-Bungarotoxin"), p(HGNC:CHRNA7), p(MESH:"Heterotrimeric GTP-Binding Proteins")) increases complex(a(HBP:"alpha-Bungarotoxin"), p(MESH:"Heterotrimeric GTP-Binding Proteins"))
pmid:21958873 p(HBP:"alpha-Bungarotoxin") causesNoChange a(CHEBI:"amyloid-beta")
pmid:21958873 p(HBP:"alpha-Bungarotoxin") decreases act(a(MESH:"Receptors, Nicotinic"))
pmid:26088141 p(HBP:"GPBC, alpha-7 nAChR") orthologous p(HBP:"GPBC, Glycine Receptor 1")
pmid:26088141 p(HBP:"GPBC, Glycine Receptor 1") orthologous p(HBP:"GPBC, alpha-7 nAChR")
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases bp(HBP:"nAChR assembly")
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases p(HGNC:CHRNA7)
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:choline))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases a(CHEBI:"calcium(2+)")
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:"calcium(2+)", loc(GO:intracellular)))
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(GO:"calcium-mediated signaling")
pmid:26088141 p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains")
pmid:26088141 g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))
pmid:26088141 composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)")
pmid:26088141 composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)")
pmid:26088141 composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)")
pmid:26088141 composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)")
pmid:26088141 a(MESH:"GP Antagonist-2A peptide") causesNoChange a(CHEBI:"calcium(2+)")
pmid:26088141 a(MESH:"GP Antagonist-2A peptide") causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")))
pmid:26088141 a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains")
pmid:26088141 a(MESH:Barium) causesNoChange bp(GO:"calcium-mediated signaling")
pmid:26088141 a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")))
pmid:26088141 a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7))
pmid:26088141 a(CHEBI:nifedipine) decreases act(a(CHEBI:choline))
pmid:26088141 a(CHEBI:nifedipine) decreases a(CHEBI:"calcium(2+)")
pmid:26088141 a(CHEBI:nifedipine) increases bp(GO:"calcium-mediated signaling")
pmid:26088141 a(CHEBI:nifedipine) causesNoChange bp(GO:"calcium-mediated signaling")
pmid:26088141 a(CHEBI:nifedipine) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")))
pmid:26088141 bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline)
pmid:26088141 a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7))
pmid:26088141 a(MESH:"xestospongin C") decreases bp(GO:"calcium-mediated signaling")
pmid:26088141 a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")))
pmid:25514383 a(MESH:"White Matter") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26195256 a(MESH:"White Matter") association path(MESH:"Alzheimer Disease")
pmid:24762290 a(MESH:"White Matter") positiveCorrelation complex(HBP:"alpha-4 beta-2 nAChR")
pmid:25514383 a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:25514383 a(HP:"cholinergic neuron") association bp(GO:cognition)
pmid:25514383 a(HP:"cholinergic neuron") increases bp(GO:cognition)
pmid:25514383 a(HP:"cholinergic neuron") association path(MESH:Attention)
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") positiveCorrelation bp(GO:"calcium ion transport")
pmid:28445721 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport")
pmid:21482353 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"calcium ion transport")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space"))
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"second-messenger-mediated signaling")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"neuron cellular homeostasis")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"gene expression")
pmid:25514383 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:25514383 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"intracellular signal transduction")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases p(FPLX:AKT, pmod(Ph))
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"ERK1 and ERK2 cascade")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(HP:Neurodegeneration)
pmid:25514383 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(HP:Neurodegeneration)
pmid:25514383 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival")
pmid:25514383 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse)
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:"pregnenolone sulfate"))
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:cognition)
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"synaptic transmission, glutamatergic")
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin))
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory)
pmid:25514383 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process")
pmid:28445721 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association bp(MESH:"Physiological Phenomena")
pmid:28445721 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Disease)
pmid:21482353 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases act(p(MGI:Lynx1))
pmid:21482353 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons")
pmid:21482353 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"sensory processing")
pmid:21482353 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"sensory processing")
pmid:21482353 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron")
pmid:21482353 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron")
pmid:21482353 a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia)
pmid:28132910 act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) negativeCorrelation a(HBP:"B-973")
pmid:30664622 a(GO:"glutamatergic synapse") association act(a(PUBCHEM:9832404))
pmid:30664622 a(GO:"glutamatergic synapse") association act(p(HGNC:ADNP))
pmid:25514383 a(HBP:"alpha-7 beta-2 nAChR") negativeCorrelation act(a(CHEBI:"amyloid-beta"))
pmid:25514383 complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases bp(HP:Neurodegeneration)
pmid:25514383 complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases a(HBP:"amyloid-beta aggregates")
pmid:25514383 p(HGNC:APP, frag("12_28")) increases complex(p(HGNC:APP, frag("12_28")), p(HGNC:CHRNA7))
pmid:25514383 complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction")
pmid:25514383 complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) decreases bp(MESH:"Cell Survival")
pmid:25514383 complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) association bp(GO:"neuron cellular homeostasis")
pmid:27522251 complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases path(MESH:"Memory Disorders")
pmid:25514383 a(PUBCHEM:637026) increases act(a(HBP:"beta-2-containing nAChR"))
pmid:25514383 a(HBP:"amyloid-beta 40 oligomers") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) increases act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:28420982 bp(GO:"intracellular signal transduction") association p(HGNC:MAPT)
pmid:25514383 a(HBP:"amyloid-beta 42 oligomers") increases bp(GO:"long-term synaptic potentiation")
pmid:28901280 bp(MESH:"Cell Survival") association a(MESH:Acetylcholine)
pmid:30126037 bp(MESH:"Cell Survival") association bp(GO:"cellular senescence")
pmid:24563850 bp(HP:Neurodegeneration) association bp(GO:"protein oxidation")
pmid:30126037 bp(HP:Neurodegeneration) association p(HGNC:CDKN2A)
pmid:28420982 bp(HP:Neurodegeneration) decreases sec(p(HGNC:MAPT))
pmid:25514383 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory")
pmid:28901280 path(MESH:"Cognition Disorders") association p(MESH:"Receptors, Nicotinic")
pmid:25514383 a(CHEBI:"(-)-cotinine") increases path(MESH:Attention)
pmid:25514383 a(CHEBI:"(-)-cotinine") increases bp(GO:memory)
pmid:25514383 a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid")
pmid:25514383 a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT))
pmid:25514383 a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:25514383 a(HBP:"S 24795") decreases a(CHEBI:"amyloid-beta")
pmid:25514383 a(HBP:"S 24795") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:25514383 a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory")
pmid:17640819 a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory")
pmid:25514383 a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:"neuron cellular homeostasis")
pmid:17640819 a(HBP:"4-OH-GTS-21") increases path(MESH:"Avoidance Learning")
pmid:17640819 a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:locomotion)
pmid:17640819 a(HBP:"4-OH-GTS-21") increases a(GO:perikaryon)
pmid:17640819 a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"Cholinergic Neurons")
pmid:17640819 a(HBP:"4-OH-GTS-21") decreases a(MESH:"Cholinergic Neurons")
pmid:17640819 a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"GABAergic Neurons")
pmid:17640819 a(HBP:"4-OH-GTS-21") causesNoChange a(CHEBI:"amyloid-beta")
pmid:25514383 a(PUBCHEM:9928899) increases bp(GO:"long-term synaptic potentiation")
pmid:25514383 a(CHEBI:"pregnenolone sulfate") increases bp(GO:cognition)
pmid:25514383 a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity")
pmid:25514383 a(CHEBI:"pregnenolone sulfate") increases bp(GO:"synaptic transmission, glutamatergic")
pmid:25514383 a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory")
pmid:25514383 a(CHEBI:"pregnenolone sulfate") decreases bp(GO:"apoptotic process")
pmid:25514383 a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis")
pmid:25514383 a(CHEBI:simvastatin) increases bp(GO:cognition)
pmid:25514383 a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process")
pmid:29626319 a(CHEBI:simvastatin) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(CHEBI:simvastatin) increases bp(GO:"ERK1 and ERK2 cascade")
pmid:29626319 a(CHEBI:simvastatin) increases sec(p(HGNC:MME))
pmid:21718217 bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3)
pmid:25514383 composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory)
pmid:25881725 p(MGI:App, frag("25_35")) decreases bp(GO:learning)
pmid:25881725 p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory")
pmid:25881725 p(MGI:App, frag("25_35")) increases a(HBP:"amyloid-beta oligomers", loc(GO:"extracellular region"))
pmid:25881725 p(MGI:App, frag("25_35")) causesNoChange r(MGI:Chrna7)
pmid:25514383 complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction")
pmid:25514383 complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25514383 a(HBP:"PTI-125") decreases complex(p(HGNC:CHRNA7), p(HGNC:FLNA))
pmid:25514383 a(HBP:"PTI-125") decreases complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN))
pmid:25514383 a(HBP:"PTI-125") increases act(a(CHEBI:"amyloid-beta"))
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders")
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders")
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders")
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion)
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety)
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation")
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia))
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response")
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022)
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022)
pmid:27522251 p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022)
pmid:27522251 composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders")
pmid:27522251 composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders")
pmid:27522251 composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(HBP:HBP00022)
pmid:27522251 complex(a(CHEBI:"amyloid-beta"), p(MGI:Chrnb2)) increases path(MESH:"Memory Disorders")
pmid:27522251 composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders")
pmid:27522251 composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders")
pmid:27522251 composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Cognitive Dysfunction")
pmid:27522251 composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases a(HBP:HBP00022)
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus)
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus)
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Pons)
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Mesencephalon)
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Corpus Striatum")
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"White Matter")
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Parkinson Disease")
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Parietal Lobe")
pmid:24762290 complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:Memory)
pmid:24762290 a(MESH:Pons) association complex(HBP:"alpha-4 beta-2 nAChR")
pmid:24762290 a(MESH:Mesencephalon) association complex(HBP:"alpha-4 beta-2 nAChR")
pmid:24762290 a(MESH:"Parietal Lobe") association complex(HBP:"alpha-4 beta-2 nAChR")
pmid:21718217 a(HBP:HBP00089) association bp(GO:"microglial cell activation")
pmid:21718217 a(HBP:HBP00089) positiveCorrelation bp(GO:"microglial cell activation")
pmid:21718217 a(HBP:HBP00089) increases sec(p(HGNC:IFNG))
pmid:21718217 a(HBP:HBP00089) increases sec(p(HGNC:TNF))
pmid:21718217 a(HBP:HBP00089) increases sec(p(HGNC:IL1B))
pmid:21718217 a(HBP:HBP00089) increases sec(p(HGNC:IL6))
pmid:21718217 a(HBP:HBP00089) increases sec(p(HGNC:CCL2))
pmid:22807490 p(HGNC:IFNG) increases p(HGNC:NOS2)
pmid:23702978 p(HGNC:IFNG) increases act(p(HGNC:NOS2))
pmid:22807490 p(HGNC:IFNG) increases p(HGNC:PTGS2)
pmid:23702978 p(HGNC:IFNG) increases p(HGNC:AIM2)
pmid:23702978 p(HGNC:IFNG) decreases act(p(HGNC:NLRP3))
pmid:23702978 p(HGNC:IFNG) increases p(HGNC:CARD17)
pmid:21718217 act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease")
pmid:21718217 act(p(HGNC:PPARG)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:21718217 act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport")
pmid:21718217 act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response")
pmid:21718217 p(HGNC:PPARG) association bp(MESH:"Energy Metabolism")
pmid:21718217 p(HGNC:PPARG) increases bp(GO:"fat cell differentiation")
pmid:21718217 p(HGNC:PPARG) association bp(GO:"response to insulin")
pmid:21718217 p(HGNC:PPARG) association bp(GO:"lipid storage")
pmid:21718217 p(HGNC:PPARG) increases p(HGNC:APOE)
pmid:21718217 p(HGNC:PPARG) increases p(HGNC:ABCA1)
pmid:21718217 p(HGNC:PPARG) increases p(HGNC:NR1H3)
pmid:21718217 act(p(HGNC:PPARG)) increases p(HGNC:ARG1)
pmid:21718217 act(p(HGNC:PPARG)) increases p(HGNC:IL4)
pmid:21718217 act(p(HGNC:NR1H3)) increases path(MESH:"Alzheimer Disease")
pmid:21718217 act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:21718217 act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:21718217 act(p(HGNC:NR1H3)) increases bp(GO:"reverse cholesterol transport")
pmid:21718217 act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation involved in immune response")
pmid:21718217 p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis")
pmid:21718217 p(HGNC:NR1H3) association bp(GO:"negative regulation of inflammatory response")
pmid:21718217 p(HGNC:NR1H3) increases p(HGNC:APOE)
pmid:21718217 act(p(HGNC:NR1H3)) increases act(p(HGNC:APOE))
pmid:21718217 p(HGNC:NR1H3) increases p(HGNC:ABCA1)
pmid:21718217 act(p(HGNC:NR1H3)) increases bp(GO:memory)
pmid:21718217 act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation")
pmid:21718217 p(FPLX:PPAR) association bp(MESH:"Energy Metabolism")
pmid:21718217 p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism")
pmid:21718217 p(FPLX:PPAR) association bp(GO:"fat cell differentiation")
pmid:21718217 p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation")
pmid:21718217 p(FPLX:PPAR) association bp(GO:"response to insulin")
pmid:21718217 p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin")
pmid:21718217 p(FPLX:PPAR) association bp(GO:"response to tumor cell")
pmid:21718217 p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell")
pmid:21718217 p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process")
pmid:21718217 act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation")
pmid:21718217 act(p(FPLX:RXR)) increases p(HGNC:APOE)
pmid:21718217 act(p(FPLX:RXR)) increases p(HGNC:ABCA1)
pmid:21718217 bp(MESH:"Energy Metabolism") association p(FPLX:PPAR)
pmid:21718217 bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR)
pmid:21718217 bp(MESH:"Energy Metabolism") association p(HGNC:PPARG)
pmid:21718217 bp(MESH:"Energy Metabolism") association p(HGNC:PPARGC1A)
pmid:25784053 bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1)
pmid:21718217 bp(GO:"fat cell differentiation") association p(FPLX:PPAR)
pmid:21718217 bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR)
pmid:21718217 bp(GO:"response to insulin") association p(FPLX:PPAR)
pmid:21718217 bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR)
pmid:21718217 bp(GO:"response to insulin") association p(HGNC:PPARG)
pmid:21718217 bp(GO:"response to tumor cell") association p(FPLX:PPAR)
pmid:21718217 bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR)
pmid:21718217 bp(GO:"lipid storage") association p(HGNC:PPARG)
pmid:21718217 p(HGNC:PPARD) association bp(GO:"fatty acid oxidation")
pmid:21718217 act(p(HGNC:PPARD)) increases bp(GO:"reverse cholesterol transport")
pmid:21718217 act(p(HGNC:PPARD)) increases bp(GO:"negative regulation of inflammatory response")
pmid:21718217 act(p(HGNC:PPARD)) increases p(HGNC:ARG1)
pmid:21718217 act(p(HGNC:PPARD)) increases p(HGNC:IL4)
pmid:21718217 bp(GO:"fatty acid oxidation") association p(HGNC:PPARD)
pmid:21718217 a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3))
pmid:21718217 a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3))
pmid:21718217 bp(GO:"negative regulation of inflammatory response") association p(HGNC:NR1H3)
pmid:21718217 a(HBP:HBP00030) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30116051 a(HBP:HBP00030) increases path(MESH:"Alzheimer Disease")
pmid:21718217 a(HBP:HBP00030) increases a(HBP:HBP00018)
pmid:30116051 a(HBP:HBP00030) increases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:30116051 a(HBP:HBP00030) increases p(HGNC:LGMN)
pmid:21718217 p(HGNC:ABCA1) increases p(HGNC:APOE)
pmid:21718217 p(HGNC:ABCA1) decreases a(HBP:HBP00018)
pmid:21718217 p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta"))
pmid:30116051 p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta"))
pmid:26195256 p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:29626319 p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta"))
pmid:28019679 p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta")
pmid:30116051 p(HGNC:IDE) increases deg(p(HGNC:IAPP))
pmid:30116051 p(HGNC:IDE) decreases a(HBP:HBP00016)
pmid:30116051 p(HGNC:IDE) decreases a(HBP:HBP00018)
pmid:30116051 p(HGNC:IDE) decreases a(HBP:HBP00092)
pmid:29626319 p(HGNC:IDE) negativeCorrelation bp(GO:aging)
pmid:29626319 p(HGNC:IDE) negativeCorrelation path(MESH:"Diabetes Mellitus")
pmid:28019679 p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex")
pmid:21718217 a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3))
pmid:21718217 a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3))
pmid:21718217 a(CHEBI:"GW 3965") increases p(HGNC:APOE)
pmid:21718217 a(CHEBI:"GW 3965") increases p(HGNC:ABCA1)
pmid:21718217 a(CHEBI:"GW 3965") decreases a(HBP:HBP00018)
pmid:21718217 a(CHEBI:"GW 3965") increases bp(GO:memory)
pmid:21718217 a(CHEBI:"GW 3965") decreases path(MESH:Inflammation)
pmid:21718217 a(CHEBI:"GW 3965") increases act(a(HBP:HBP00038))
pmid:21718217 a(CHEBI:"GW 3965") increases bp(GO:phagocytosis)
pmid:21718217 p(MGI:Abca1) decreases a(CHEBI:"amyloid-beta")
pmid:21718217 p(MGI:Abca1) decreases a(HBP:HBP00038)
pmid:21718217 a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG))
pmid:21718217 a(CHEBI:pioglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2")
pmid:21718217 a(CHEBI:pioglitazone) decreases a(HBP:HBP00018)
pmid:21718217 a(CHEBI:pioglitazone) decreases a(HBP:HBP00018)
pmid:21718217 a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:21718217 a(CHEBI:pioglitazone) increases bp(GO:behavior)
pmid:21718217 a(CHEBI:pioglitazone) increases p(MGI:Abca1)
pmid:21718217 a(CHEBI:pioglitazone) increases p(MGI:Apoe)
pmid:21718217 a(CHEBI:pioglitazone) increases bp(GO:memory)
pmid:21718217 a(CHEBI:pioglitazone) increases bp(GO:cognition)
pmid:29626319 a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta")
pmid:21718217 a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG))
pmid:21718217 a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG))
pmid:29626319 a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG))
pmid:21718217 a(CHEBI:rosiglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2")
pmid:21718217 a(CHEBI:rosiglitazone) increases bp(GO:behavior)
pmid:21718217 a(CHEBI:rosiglitazone) causesNoChange a(HBP:HBP00018)
pmid:21718217 a(CHEBI:rosiglitazone) decreases a(HBP:HBP00018)
pmid:21718217 a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:21718217 a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(CHEBI:rosiglitazone) increases deg(a(CHEBI:"amyloid-beta"))
pmid:21718217 a(CHEBI:rosiglitazone) increases bp(GO:"learning or memory")
pmid:21718217 a(CHEBI:rosiglitazone) increases p(MGI:Ctnnb1)
pmid:21718217 a(CHEBI:rosiglitazone) decreases p(MGI:Gsk3b)
pmid:21718217 a(CHEBI:rosiglitazone) increases p(MGI:Abca1)
pmid:21718217 a(CHEBI:rosiglitazone) increases bp(GO:memory)
pmid:21718217 a(CHEBI:rosiglitazone) increases bp(GO:cognition)
pmid:29626319 a(CHEBI:rosiglitazone) increases act(a(MESH:Microglia))
pmid:19732809 path(MESH:"Diabetes Mellitus, Type 2") negativeCorrelation a(HBP:"O-GlcNAcylation")
pmid:22798221 act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404))
pmid:22798221 act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198))
pmid:22798221 act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199))
pmid:22798221 act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202))
pmid:22798221 act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231))
pmid:22798221 act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:22798221 act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205))
pmid:21718217 a(CHEBI:"GW 501516") increases act(p(HGNC:PPARD))
pmid:21718217 a(CHEBI:"GW 501516") increases p(HGNC:ABCA1)
pmid:21718217 a(CHEBI:"GW 501516") increases p(HGNC:APOA1)
pmid:21718217 a(CHEBI:"GW 501516") decreases a(HBP:HBP00018)
pmid:21718217 a(CHEBI:"GW 501516") increases p(HGNC:MME)
pmid:21718217 a(CHEBI:"GW 501516") increases p(HGNC:IDE)
pmid:21718217 a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RXR))
pmid:21718217 a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RAR))
pmid:21718217 a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:HBP00018)
pmid:21718217 a(CHEBI:"all-trans-retinoic acid") decreases p(HGNC:MAPT, pmod(Ph))
pmid:21718217 a(CHEBI:"all-trans-retinoic acid") increases bp(GO:memory)
pmid:26400044 a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid")
pmid:26400044 a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:"APP processing")
pmid:26400044 a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(kin))
pmid:26400044 a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(kin))
pmid:26400044 a(CHEBI:"all-trans-retinoic acid") decreases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph)))
pmid:21718217 a(CHEBI:bexarotene) increases act(p(FPLX:RXR))
pmid:21718217 a(CHEBI:bexarotene) increases p(HGNC:APOE)
pmid:21718217 a(CHEBI:bexarotene) increases p(HGNC:ABCA1)
pmid:21718217 a(CHEBI:bexarotene) decreases a(HBP:HBP00018)
pmid:21718217 a(CHEBI:bexarotene) increases bp(GO:behavior)
pmid:21718217 a(CHEBI:Honokiol) increases act(p(FPLX:RXR))
pmid:21718217 a(CHEBI:Honokiol) increases act(complex(p(FPLX:RXR), p(HGNC:NR1H3)))
pmid:21718217 a(CHEBI:Honokiol) increases p(HGNC:APOE)
pmid:21718217 a(CHEBI:Honokiol) increases p(HGNC:ABCA1)
pmid:21718217 r(HGNC:ARG1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:11230871 bp(MESH:"Lipid Peroxidation") decreases p(FPLX:CHRN)
pmid:21718217 p(HGNC:PPARGC1A) association bp(MESH:"Energy Metabolism")
pmid:21718217 p(HGNC:PPARGC1A) association path(MESH:"Insulin Resistance")
pmid:21718217 p(HGNC:PPARGC1A) increases bp(GO:"fat cell differentiation")
pmid:21718217 a(CHEBI:cholesterol) increases act(p(HGNC:NR1H3))
pmid:19721446 a(CHEBI:cholesterol) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:29758300 a(CHEBI:cholesterol) increases a(MESH:"Amyloid beta-Peptides")
pmid:29758300 a(CHEBI:cholesterol) regulates act(complex(GO:"gamma-secretase complex"))
pmid:22908190 a(CHEBI:cholesterol) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
pmid:22908190 a(CHEBI:cholesterol) positiveCorrelation bp(GO:endocytosis)
pmid:22908190 a(CHEBI:cholesterol) increases a(GO:endosome)
pmid:21718217 p(HBP:HBP00030) association path(MESH:"Alzheimer Disease")
pmid:21718217 p(HGNC:IL10) decreases a(MESH:Macrophages)
pmid:21718217 a(MESH:Glucocorticoids) decreases a(MESH:Macrophages)
pmid:28445721 path(MESH:Motivation) association p(FPLX:CHRN)
pmid:28445721 bp(MESH:"Physiological Phenomena") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:28445721 path(MESH:Disease) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:28445721 p(HGNC:RIC3) increases act(p(FPLX:CHRN))
pmid:28445721 p(HGNC:RIC3) increases act(p(FPLX:CHRN))
pmid:28445721 p(HGNC:RIC3) increases act(p(FPLX:CHRN))
pmid:22040696 act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN)
pmid:22040696 p(HGNC:RIC3) increases act(p(FPLX:CHRN))
pmid:22040696 act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN)
pmid:28445721 p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2"))
pmid:28445721 p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28445721 p(HGNC:RIC3) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:22040696 p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic")
pmid:22040696 p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4)))
pmid:22040696 p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))
pmid:22040696 p(HGNC:RIC3) increases p(HGNC:CHRNA9)
pmid:22040696 p(HGNC:RIC3) increases p(HGNC:CHRNA7)
pmid:22040696 act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Bipolar Disorder")
pmid:22040696 act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Psychotic Disorders")
pmid:28445721 p(HGNC:TMEM35A) regulates act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) regulates surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) regulates a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28445721 p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR))
pmid:28445721 p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Serotonin"))
pmid:28445721 p(HGNC:TMEM35A) causesNoChange act(p(HGNC:TRPV1))
pmid:28445721 p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Glutamate"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases act(a(HBP:HBP00174))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(HBP:HBP00174))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases a(HBP:HBP00174)
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta2"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta2"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta2")
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta4"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta4"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta4")
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2"))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174))
pmid:28445721 act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4"))
pmid:28445721 p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor"))
pmid:28445721 p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor"))
pmid:28445721 p(HGNC:TMEM35A) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")
pmid:28445721 act(p(MGI:Tmem35a), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:28445721 p(MGI:Tmem35a) association p(MGI:Canx)
pmid:28445721 p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), p(FPLX:CHRN))
pmid:28445721 p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00180))
pmid:28445721 p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174))
pmid:28445721 p(MGI:Tmem35a) increases a(HBP:HBP00180)
pmid:28445721 p(MGI:Tmem35a) increases complex(a(GO:membrane), a(MESH:Bungarotoxins))
pmid:28445721 p(MGI:Tmem35a) increases p(FPLX:CHRN)
pmid:28445721 p(MGI:Tmem35a) regulates p(FPLX:CHRN)
pmid:28445721 p(MGI:Tmem35a) increases a(MESH:"nicotinic receptor alpha3beta4")
pmid:28445721 p(MGI:Tmem35a) decreases bp(GO:locomotion)
pmid:28445721 p(MGI:Tmem35a) decreases bp(GO:locomotion)
pmid:28445721 p(MGI:Tmem35a) association bp(GO:"temperature homeostasis")
pmid:28445721 p(MGI:Tmem35a) increases bp(GO:learning)
pmid:28445721 p(MGI:Tmem35a) increases bp(GO:memory)
pmid:28445721 p(MGI:Tmem35a) increases path(MESH:"Spatial Learning")
pmid:28445721 p(MGI:Tmem35a) increases path(MESH:"Spatial Memory")
pmid:11230871 complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging)
pmid:11230871 complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging)
pmid:28445721 p(MGI:Canx) association p(MGI:Tmem35a)
pmid:18174175 complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) increases act(a(MESH:"alpha6beta2 nicotinic acetylcholine receptor"))
pmid:21787755 a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:28445721 a(MESH:"alpha-conotoxin MII") decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor"))
pmid:21787755 a(MESH:"alpha-conotoxin MII") decreases act(a(HBP:"alpha-3 beta-2 nAChR"))
pmid:28445721 bp(GO:"temperature homeostasis") association p(MGI:Tmem35a)
pmid:21482353 a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:27671637 a(MESH:"Presynaptic Terminals") causesNoChange p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:21482353 p(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:Epilepsy)
pmid:21482353 p(HGNC:CHRNA4, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy")
pmid:21482353 p(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:Epilepsy)
pmid:21482353 p(HGNC:CHRNB2, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy")
pmid:21482353 p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder")
pmid:21482353 p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder")
pmid:21482353 p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:Alcoholism)
pmid:21482353 p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders")
pmid:21482353 p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders")
pmid:21482353 p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms")
pmid:21482353 p(HGNC:CHRNA5, var("?")) positiveCorrelation bp(GO:cognition)
pmid:21482353 complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases p(FPLX:CHRN)
pmid:21482353 complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases act(p(FPLX:CHRN))
pmid:21482353 complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases p(FPLX:CHRN)
pmid:21482353 complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN))
pmid:21482353 complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases p(FPLX:CHRN)
pmid:21482353 complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases act(p(FPLX:CHRN))
pmid:21482353 complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases p(FPLX:CHRN)
pmid:21482353 complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases act(p(FPLX:CHRN))
pmid:19721446 p(HGNC:VSNL1) association p(HGNC:CHRNA4, frag("331_600"))
pmid:21482353 complex(p(FPLX:CHRN), p(HGNC:LYNX1)) regulates act(p(FPLX:CHRN))
pmid:21482353 complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association act(p(FPLX:CHRN))
pmid:21482353 complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association surf(p(FPLX:CHRN))
pmid:21482353 p(HGNC:LYNX1) regulates act(p(FPLX:CHRN))
pmid:21482353 p(HGNC:LYNX1) decreases act(p(FPLX:CHRN))
pmid:21482353 p(HGNC:LYNX1) decreases act(p(FPLX:CHRN))
pmid:21482353 p(HGNC:LYNX1) regulates act(p(FPLX:CHRN))
pmid:21482353 p(HGNC:LYNX1) decreases bp(GO:"synaptic transmission, cholinergic")
pmid:21482353 p(HGNC:LYNX1) association bp(GO:"synaptic transmission, cholinergic")
pmid:21482353 p(HGNC:LYNX1) association path(MESH:"Cognitive Dysfunction")
pmid:21482353 p(HGNC:LYNX1) positiveCorrelation bp(GO:"neuron maturation")
pmid:21482353 p(HGNC:LYNX1) negativeCorrelation bp(GO:"synapse maturation")
pmid:21482353 p(HGNC:LYNX1) regulates bp(GO:"generation of neurons")
pmid:28901280 p(HGNC:LYNX1) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))
pmid:28901280 p(HGNC:LYNX1) decreases act(p(HGNC:CHRNA7))
pmid:21482353 composite(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) decreases act(p(FPLX:CHRN))
pmid:21482353 complex(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-4 beta-2 nAChR"))
pmid:21482353 complex(p(HGNC:CHRNA3), p(HGNC:LYNX1)) regulates act(p(HGNC:CHRNA3))
pmid:21482353 complex(a(HBP:"alpha-7-containing nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-7-containing nAChR"))
pmid:21482353 a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5)
pmid:21482353 a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5)
pmid:21482353 a(HBP:"alpha-7-containing nAChR") association bp(GO:"macrophage activation")
pmid:21482353 a(HBP:"alpha-7-containing nAChR") association bp(GO:"response to cytokine")
pmid:11230871 a(HBP:"alpha-7-containing nAChR") negativeCorrelation bp(GO:aging)
pmid:11230871 a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:11230871 a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:Schizophrenia)
pmid:11230871 a(HBP:"alpha-7-containing nAChR") regulates act(a(CHEBI:"amyloid-beta"))
pmid:21787755 a(HBP:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:21787755 a(HBP:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission")
pmid:21787755 a(HBP:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion")
pmid:21787755 a(HBP:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure")
pmid:21787755 a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance")
pmid:21787755 a(HBP:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation")
pmid:21787755 a(HBP:"alpha-7-containing nAChR") association path(MESH:Seizures)
pmid:21787755 a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron death")
pmid:21482353 p(MGI:Lynx1) decreases a(CHEBI:"calcium(2+)")
pmid:21482353 p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission")
pmid:21482353 p(MGI:Lynx1) decreases bp(GO:learning)
pmid:21482353 p(MGI:Lynx1) decreases bp(GO:memory)
pmid:21482353 p(MGI:Lynx1) decreases bp(MESH:"Dominance, Ocular")
pmid:21482353 p(MGI:Lynx1) decreases bp(GO:"synaptic transmission, cholinergic")
pmid:21482353 p(MGI:Lynx1) increases a(MESH:Neurons)
pmid:21482353 act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN))
pmid:22299660 a(MESH:Brain) association p(HGNC:PPP2R2A)
pmid:24027553 a(MESH:Brain) association act(p(HGNC:NPEPPS))
pmid:21482353 p(MGI:Slc12a2) increases act(p(MGI:Lynx1))
pmid:21482353 p(FPLX:ADCY, var("?")) decreases act(p(MGI:Lynx1))
pmid:21482353 p(HGNC:PSCA) decreases bp(GO:"programmed cell death")
pmid:21482353 bp(GO:"neuron maturation") positiveCorrelation p(HGNC:LYNX1)
pmid:21482353 bp(GO:"synapse maturation") negativeCorrelation p(HGNC:LYNX1)
pmid:21482353 bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:21482353 bp(GO:"GABAergic neuron differentiation") association path(MESH:Schizophrenia)
pmid:21482353 bp(GO:"GABAergic neuron differentiation") association path(MESH:Amblyopia)
pmid:21482353 path(MESH:Amblyopia) association bp(GO:"GABAergic neuron differentiation")
pmid:21482353 a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing")
pmid:21482353 act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS))
pmid:21482353 a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:21482353 act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?"))
pmid:24563850 act(p(FPLX:NOS)) increases a(CHEBI:radical)
pmid:24563850 act(p(FPLX:NOS)) increases a(CHEBI:"reactive oxygen species")
pmid:24563850 act(p(FPLX:NOS)) increases a(CHEBI:"reactive nitrogen species")
pmid:21482353 a(MESH:"Brain Stem") regulates act(a(MESH:Hippocampus))
pmid:21482353 g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia)
pmid:21482353 g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron"))
pmid:21482353 g(HGNC:NRG1) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
pmid:21482353 a(HBP:"GTS-21") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:21482353 a(HBP:"GTS-21") increases path(MESH:Attention)
pmid:21482353 a(HBP:"GTS-21") increases bp(GO:"sensory processing")
pmid:21482353 a(HBP:"GTS-21") decreases path(MESH:Anhedonia)
pmid:21482353 a(HBP:"GTS-21") decreases path(MESH:Aphasia)
pmid:21482353 p(HGNC:SLC12A5) decreases a(CHEBI:chloride)
pmid:21482353 p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid"))
pmid:21482353 p(HGNC:PEMT) increases a(CHEBI:phosphatidylcholine)
pmid:21482353 a(CHEBI:phosphatidylcholine) increases a(CHEBI:choline)
pmid:21482353 p(HGNC:PEMT, var("?")) association path(MESH:"Choline Deficiency")
pmid:21482353 p(HGNC:PEMT, var("?")) association path(MESH:Schizophrenia)
pmid:21482353 path(MESH:"Choline Deficiency") association p(HGNC:PEMT, var("?"))
pmid:21482353 bp(GO:"macrophage activation") association a(HBP:"alpha-7-containing nAChR")
pmid:21482353 bp(GO:"response to cytokine") association a(HBP:"alpha-7-containing nAChR")
pmid:21482353 bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine)
pmid:23746257 bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins")
pmid:25784053 bp(MESH:"Stress, Physiological") regulates bp(HBP:Proteostasis)
pmid:21482353 path(MESH:Fear) increases a(CHEBI:dopamine)
pmid:21482353 path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA5, var("?"))
pmid:21482353 path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA3, var("?"))
pmid:21482353 path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNB4, var("?"))
pmid:21482353 path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?"))
pmid:21482353 path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?"))
pmid:21482353 path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?"))
pmid:21482353 path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?"))
pmid:21482353 path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?"))
pmid:21482353 path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?"))
pmid:21482353 path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?"))
pmid:21482353 path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?"))
pmid:21482353 path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?"))
pmid:19721446 path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5)
pmid:19721446 path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3)
pmid:19721446 path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4)
pmid:28901280 path(MESH:"Lung Neoplasms") association g(DNSNP:rs1051730)
pmid:28901280 path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9)
pmid:28901280 path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5)
pmid:28901280 path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10)
pmid:21482353 p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder")
pmid:21482353 p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:Alcoholism)
pmid:21482353 p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders")
pmid:21482353 p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders")
pmid:21482353 p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms")
pmid:21482353 p(HGNC:CHRNA3, var("?")) positiveCorrelation bp(GO:cognition)
pmid:21482353 p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder")
pmid:21482353 p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:Alcoholism)
pmid:21482353 p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders")
pmid:21482353 p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders")
pmid:21482353 p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms")
pmid:21482353 p(HGNC:CHRNB4, var("?")) positiveCorrelation bp(GO:cognition)
pmid:21482353 path(MESH:"Tobacco Use") decreases path(MESH:"Parkinson Disease")
pmid:18986241 path(MESH:D019636) association path(MESH:D000544)
pmid:18986241 path(MESH:D001526) association path(MESH:D000544)
pmid:18986241 path(HBP:aMCI) association path(MESH:D008569)
pmid:18986241 path(HBP:aMCI) association path(MESH:D003704)
pmid:18986241 path(HBP:aMCI) association path(MESH:D000544)
pmid:18986241 path(MESH:D008569) association path(HBP:aMCI)
pmid:18986241 path(HBP:mdMCI) association path(MESH:D060825)
pmid:18986241 path(MESH:D060825) association path(HBP:mdMCI)
pmid:18986241 path(MESH:D060825) association path(MESH:D062706)
pmid:18986241 path(MESH:D060825) association bp(HBP:Neurodegeneration)
pmid:18986241 path(MESH:D060825) causesNoChange act(p(HGNC:CHAT))
pmid:18986241 path(MESH:D060825) increases act(p(HGNC:CHAT))
pmid:18986241 path(MESH:D060825) increases act(p(HGNC:CHAT))
pmid:18986241 path(MESH:D060825) decreases a(MESH:D013569)
pmid:18986241 path(MESH:D060825) increases act(p(HGNC:MMP9))
pmid:18986241 path(MESH:D060825) causesNoChange r(HGNC:CHAT)
pmid:18986241 path(MESH:D060825) association p(HGNC:CHRM1)
pmid:18986241 path(MESH:D060825) decreases a(HBP:"3R tau")
pmid:18986241 path(MESH:D062706) association path(MESH:D060825)
pmid:18986241 a(MESH:D059329) directlyIncreases bp(GO:"GO:0060384")
pmid:18986241 a(MESH:D059329) association path(MESH:D008568)
pmid:18986241 a(MESH:D059329) association path(MESH:D001288)
pmid:18986241 a(MESH:D059329) association a(MESH:D016874)
pmid:18986241 a(MESH:D059329) association path(MESH:D000544)
pmid:18986241 a(MESH:D059329) association a(MESH:D009479)
pmid:18986241 a(MESH:D059329) association a(MESH:D059330)
pmid:18986241 a(MESH:D059329) association p(RGD:Gal)
pmid:18986241 a(MESH:D059329) association path(MESH:D008570)
pmid:18986241 a(MESH:D059329) association path(MESH:D003704)
pmid:18986241 bp(GO:"GO:0060384") association p(HGNC:NGF)
pmid:18986241 path(MESH:D001288) association a(MESH:D059329)
pmid:18986241 a(MESH:D016874) association a(MESH:D059329)
pmid:18986241 a(MESH:D016874) association path(MESH:D000544)
pmid:18986241 a(MESH:D016874) association p(HGNC:BCHE)
pmid:18986241 a(MESH:D009479) association a(MESH:D059329)
pmid:18986241 a(MESH:D059330) association a(MESH:D059329)
pmid:18986241 p(RGD:Gal) association a(MESH:D059329)
pmid:18986241 path(MESH:D008570) association a(MESH:D059329)
pmid:18986241 a(MESH:D005625) positiveCorrelation path(MESH:D011597)
pmid:18986241 path(MESH:D011597) positiveCorrelation a(MESH:D005625)
pmid:18986241 p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE)
pmid:18986241 complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0038180")
pmid:18986241 complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175")
pmid:18986241 p(HGNC:NTRK1) negativeCorrelation path(MESH:D003072)
pmid:18986241 p(HGNC:NTRK1) biomarkerFor path(MESH:D000544)
pmid:18986241 p(HGNC:NTRK1) decreases act(p(HGNC:BACE1))
pmid:18986241 bp(GO:"GO:0038180") increases bp(GO:"GO:1990089")
pmid:18986241 complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1))
pmid:18986241 bp(GO:"GO:1901214") association p(HGNC:NGFR)
pmid:18986241 path(MESH:D003072) negativeCorrelation p(HGNC:NTRK1)
pmid:18986241 path(MESH:D003072) positiveCorrelation act(p(HGNC:MMP9))
pmid:18986241 bp(MESH:D000375) increases p(HGNC:NGFR)
pmid:18986241 p(HGNC:SORT1) association path(MESH:D000544)
pmid:18986241 act(p(HGNC:MMP9)) positiveCorrelation path(MESH:D003072)
pmid:27594586 p(HGNC:MMP9) increases p(HGNC:HTT, frag("?"))
pmid:27594586 act(p(HGNC:MMP9)) association path(MESH:"Neurodevelopmental Disorders")
pmid:27594586 act(p(HGNC:MMP9)) increases bp(GO:"neuron death")
pmid:27594586 p(HGNC:MMP9) increases bp(GO:"neuron death")
pmid:27594586 act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph))
pmid:27594586 sec(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph))
pmid:29626319 act(p(HGNC:MMP9)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:MMP9) increases deg(a(CHEBI:"amyloid-beta"))
pmid:18986241 g(HGNC:NTRK1) association path(MESH:D003071)
pmid:18986241 g(HGNC:NTRK2) association path(MESH:D003071)
pmid:18986241 g(HGNC:NTRK3) association path(MESH:D003071)
pmid:18986241 bp(GO:"GO:0000165") association bp(GO:"GO:0006915")
pmid:18986241 bp(GO:"GO:0000165") association bp(GO:"GO:0030182")
pmid:18986241 bp(GO:"GO:0000165") increases act(p(FPLX:RAS))
pmid:18986241 bp(GO:"GO:0000165") increases act(p(FPLX:RAF))
pmid:18986241 bp(GO:"GO:0000165") increases act(p(FPLX:MEK))
pmid:18986241 bp(GO:"GO:0000165") increases act(p(FPLX:P90RSK))
pmid:18986241 bp(GO:"GO:0000165") increases act(p(HGNC:MAPKAPK2))
pmid:18986241 bp(GO:"GO:0006915") association bp(GO:"GO:0000165")
pmid:18986241 bp(GO:"GO:0030182") association bp(GO:"GO:0000165")
pmid:18986241 act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(Ph))
pmid:18986241 act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(Ph))
pmid:18986241 bp(GO:"GO:0014065") regulates bp(MESH:D002470)
pmid:18986241 bp(GO:"GO:0014065") association p(FPLX:RAS)
pmid:18986241 bp(GO:"GO:0014065") association p(HGNC:IRS1)
pmid:18986241 bp(GO:"GO:0014065") association p(HGNC:GAB1)
pmid:18986241 bp(GO:"GO:0043491") regulates bp(MESH:D002470)
pmid:18986241 bp(GO:"GO:0043491") association p(FPLX:RAS)
pmid:18986241 bp(GO:"GO:0043491") association p(HGNC:IRS1)
pmid:18986241 bp(GO:"GO:0043491") association p(HGNC:GAB1)
pmid:18986241 p(HGNC:IRS1) association bp(GO:"GO:0014065")
pmid:18986241 p(HGNC:IRS1) association bp(GO:"GO:0043491")
pmid:18986241 p(HGNC:GAB1) association bp(GO:"GO:0014065")
pmid:18986241 p(HGNC:GAB1) association bp(GO:"GO:0043491")
pmid:18986241 act(p(HGNC:PLCG1)) association bp(MESH:D018384)
pmid:18467332 p(HGNC:PLCG1) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1))
pmid:18986241 bp(MESH:D018384) association act(p(HGNC:PLCG1))
pmid:18986241 bp(MESH:D018384) association path(MESH:D000375)
pmid:18986241 bp(MESH:D018384) association path(MESH:D009410)
pmid:18986241 path(MESH:D000375) association bp(MESH:D018384)
pmid:18986241 path(MESH:D009410) association bp(MESH:D018384)
pmid:18986241 bp(GO:"GO:0006665") association act(p(HGNC:NGFR))
pmid:18986241 p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0043491")
pmid:18986241 p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0000165")
pmid:18986241 path(MESH:D024801) association p(HGNC:CHRM1)
pmid:18986241 path(MESH:D000686) association p(HGNC:CHRM1)
pmid:26751493 r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle")
pmid:18986241 bp(HBP:hyperphosphorylation) association path(MESH:D016874)
pmid:17493042 p(HBP:"Tau isoform B (381 aa)") partOf a(MESH:Brain)
pmid:23407988 p(HBP:"Tau isoform B (381 aa)") isA p(HBP:"3R tau")
pmid:17493042 p(HBP:"Tau isoform C (410 aa)") partOf a(MESH:Brain)
pmid:23407988 p(HBP:"Tau isoform C (410 aa)") isA p(HBP:"3R tau")
pmid:17493042 p(HBP:"Tau isoform D (383 aa)") partOf a(MESH:Brain)
pmid:23407988 p(HBP:"Tau isoform D (383 aa)") isA p(HBP:"4R tau")
pmid:17493042 p(HBP:"Tau isoform E (412 aa)") partOf a(MESH:Brain)
pmid:23407988 p(HBP:"Tau isoform E (412 aa)") isA p(HBP:"4R tau")
pmid:29191965 p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"anterograde axonal transport of mitochondrion")
pmid:29191965 p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"retrograde axonal transport of mitochondrion")
pmid:25374103 p(HBP:"Tau isoform F (441 aa)") causesNoChange bp(GO:"cell death")
pmid:25374103 p(HBP:"Tau isoform F (441 aa)") positiveCorrelation act(p(HGNC:CASP3))
pmid:25374103 p(HBP:"Tau isoform F (441 aa)") negativeCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 p(HBP:"Tau isoform F (441 aa)") negativeCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:17493042 p(HBP:"Tau isoform F (441 aa)") partOf a(MESH:Brain)
pmid:23407988 p(HBP:"Tau isoform F (441 aa)") isA p(HBP:"4R tau")
pmid:30145931 r(HGNC:MAPT, loc(MESH:Dendrites)) increases p(HGNC:MAPT, loc(MESH:Dendrites))
pmid:27574109 a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
pmid:27574109 a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
pmid:27574109 a(HBP:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization")
pmid:27574109 a(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27574109 a(HBP:"3R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:18986241 act(p(HGNC:GAL)) association path(MESH:D003071)
pmid:18986241 act(p(HGNC:GAL)) association bp(MESH:D009473)
pmid:18986241 act(p(HGNC:GAL)) increases bp(GO:"GO:0060384")
pmid:18986241 act(p(HGNC:GAL)) regulates act(a(MESH:D059329))
pmid:18986241 act(p(HGNC:GAL)) decreases a(CHEBI:"amyloid-beta")
pmid:18986241 act(p(HGNC:GAL)) increases r(HGNC:CHAT)
pmid:18986241 act(p(HGNC:GAL)) causesNoChange a(HBP:"Tau MN423")
pmid:18986241 act(p(HGNC:GAL)) increases r(HGNC:PPP1CA)
pmid:18986241 act(p(HGNC:GAL)) increases r(HGNC:PPP1CC)
pmid:18986241 bp(MESH:D009473) association act(p(HGNC:GAL))
pmid:18986241 a(HBP:"Tau C3") biomarkerFor path(MESH:D059329)
pmid:18986241 p(RGD:Ngf) increases r(RGD:Gal)
pmid:18986241 p(RGD:Ngf) decreases path(MESH:D060825)
pmid:18986241 bp(GO:"GO:0050435") association a(MESH:D002800)
pmid:18986241 path(MESH:D007319) association a(MESH:D002800)
pmid:18986241 path(MESH:D003967) association a(MESH:D002800)
pmid:18986241 path(MESH:D009325) association a(MESH:D002800)
pmid:18986241 path(MESH:D005221) association a(MESH:D002800)
pmid:18986241 path(MESH:D000855) association a(MESH:D002800)
pmid:18986241 bp(GO:"GO:0007269") association p(HGNC:NGF)
pmid:18986241 bp(GO:"GO:0048485") association p(HGNC:NGF)
pmid:18986241 path(MESH:D002100) association p(HGNC:NGF)
pmid:18986241 path(MESH:D006930) association p(HGNC:NGF)
pmid:18986241 g(HGNC:NGF) directlyIncreases p(HGNC:NGF)
pmid:11230871 a(MESH:"Neurotransmitter Agents") association p(FPLX:CHRN)
pmid:11230871 path(MESH:"Tourette Syndrome") association p(FPLX:CHRN)
pmid:11230871 a(PUBCHEM:5662) association bp(GO:"synaptic transmission, cholinergic")
pmid:11230871 a(PUBCHEM:132228) increases p(FPLX:CHRN)
pmid:11230871 a(CHEBI:Ondansetron) decreases p(FPLX:CHRN)
pmid:11230871 a(PUBCHEM:119380) increases path(MESH:"Verbal Learning")
pmid:11230871 a(PUBCHEM:119380) increases bp(GO:memory)
pmid:28132910 a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28132910 a(HBP:"B-973") negativeCorrelation act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28132910 a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28132910 a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28132910 a(HBP:"B-973") increases act(a(CHEBI:acetylcholine))
pmid:28132910 a(HBP:"B-973") increases complex(a(GO:membrane), a(PUBCHEM:16068384))
pmid:28132910 a(HBP:"B-973") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384))
pmid:28132910 a(HBP:"B-973") increases complex(a(PUBCHEM:16068384), p(MGI:Chrna7))
pmid:28132910 a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28391535 a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28391535 a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:28391535 a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine))
pmid:28391535 a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine))
pmid:17640819 composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")), p(MGI:Psen1, var("p.Met146Leu"))) increases a(CHEBI:"amyloid-beta")
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35")))
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35")))
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning)
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning)
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory")
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory")
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") causesNoChange r(MGI:Chrna7)
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7)
pmid:25881725 a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7)
pmid:19721446 a(MESH:"Peripheral Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19721446 a(MESH:"Central Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
pmid:19721446 bp(GO:"regulation of cation channel activity") association a(CHEBI:acetylcholine)
pmid:19721446 p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"))
pmid:19721446 p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458))
pmid:19721446 act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255"))
pmid:19721446 act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280"))
pmid:19721446 act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490"))
pmid:19721446 p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"))
pmid:19721446 p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458))
pmid:19721446 p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea"))
pmid:19721446 p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458))
pmid:19721446 act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255"))
pmid:19721446 act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280"))
pmid:19721446 act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490"))
pmid:19721446 p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:YWHAH)
pmid:19721446 p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:VSNL1)
pmid:19721446 p(HGNC:YWHAH) association p(HGNC:CHRNA4, frag("331_600"))
pmid:19721446 p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2)
pmid:19721446 p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2)
pmid:19721446 a(MESH:"AR-R 17779") increases bp(GO:learning)
pmid:19721446 a(MESH:"AR-R 17779") increases bp(GO:memory)
pmid:19721446 a(MESH:"AR-R 17779") decreases act(a(CHEBI:scopolamine))
pmid:19721446 a(DRUGBANK:Facinicline) increases bp(GO:cognition)
pmid:19721446 a(DRUGBANK:Facinicline) increases bp(GO:memory)
pmid:19721446 a(DRUGBANK:Facinicline) increases path(MESH:"Memory, Episodic")
pmid:19721446 a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid") increases path(HBP:neurotoxicity)
pmid:19721446 a(MESH:"Entorhinal Cortex") association bp(GO:memory)
pmid:19721446 path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole")
pmid:19721446 path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:pozanicline)
pmid:19721446 a(MESH:pozanicline) association path(MESH:"Attention Deficit Disorder with Hyperactivity")
pmid:19721446 bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia)
pmid:19721446 bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7)
pmid:19721446 a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating")
pmid:19721446 a(CHEBI:clozapine) association p(HGNC:CHRNA7)
pmid:19721446 a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7))
pmid:19721446 a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating")
pmid:19721446 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine))
pmid:19721446 a(MESH:"Dihydro-beta-Erythroidine") decreases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:28901280 a(MESH:"Dihydro-beta-Erythroidine") decreases p(MESH:"Receptors, Nicotinic")
pmid:28901280 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:Nicotine))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2"))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic"))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic"))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), p(HGNC:CHRNB2))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha3beta2"))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha4beta2"))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha3beta4"))
pmid:28391535 a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:19721446 a(CHEBI:varenicline) increases path(MESH:"Smoking Cessation")
pmid:19721446 a(CHEBI:varenicline) increases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19721446 a(CHEBI:varenicline) increases act(p(HGNC:CHRNA7))
pmid:28391535 a(CHEBI:varenicline) increases act(a(MESH:"nicotinic receptor alpha4beta2"))
pmid:28391535 a(CHEBI:varenicline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))
pmid:19721446 complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons")
pmid:19721446 complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons")
pmid:19721446 complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons")
pmid:19721446 g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms")
pmid:19721446 g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms")
pmid:19721446 g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms")
pmid:19721446 path(MESH:Recurrence) association p(HGNC:CHRNA3)
pmid:19721446 path(MESH:Recurrence) association p(HGNC:CHRNB4)
pmid:19721446 a(CHEBI:fluoxetine) decreases a(CHEBI:monoamine)
pmid:19721446 a(CHEBI:fluoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19721446 a(CHEBI:sertraline) decreases a(CHEBI:monoamine)
pmid:19721446 a(CHEBI:sertraline) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19721446 a(CHEBI:paroxetine) decreases a(CHEBI:monoamine)
pmid:19721446 a(CHEBI:paroxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19721446 a(CHEBI:nefazodone) decreases a(CHEBI:monoamine)
pmid:19721446 a(CHEBI:nefazodone) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19721446 a(CHEBI:nisoxetine) decreases a(CHEBI:monoamine)
pmid:19721446 a(CHEBI:nisoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19721446 a(CHEBI:nomifensine) decreases a(CHEBI:monoamine)
pmid:19721446 a(CHEBI:nomifensine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19721446 a(CHEBI:vanoxerine) decreases a(CHEBI:monoamine)
pmid:19721446 a(CHEBI:vanoxerine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
pmid:19721446 a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19721446 a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Vomiting)
pmid:19721446 a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Nausea)
pmid:19721446 a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4)))
pmid:19721446 a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(HBP:"alpha-4 beta-2 nAChR"))
pmid:19721446 complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins)
pmid:19721446 complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes))
pmid:28901280 complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic")
pmid:28901280 path(MESH:Pain) association p(MESH:"Receptors, Nicotinic")
pmid:22040696 p(FPLX:Cyclophilin) increases p(HGNC:CHRNA7)
pmid:22040696 p(FPLX:"p14_3_3") increases p(FPLX:CHRN)
pmid:22040696 p(HGNC:HSPA5) increases p(FPLX:CHRN)
pmid:22040696 p(HGNC:CANX) increases p(FPLX:CHRN)
pmid:22040696 complex(GO:"proteasome complex") regulates p(FPLX:CHRN)
pmid:22040696 complex(GO:"proteasome complex") increases bp(GO:"modulation of chemical synaptic transmission")
pmid:22040696 complex(GO:"proteasome complex") regulates p(HGNC:RIC3)
pmid:29758300 complex(GO:"proteasome complex") association p(HGNC:MAPT, pmod(Ph))
pmid:29758300 complex(GO:"proteasome complex") increases deg(p(HGNC:SNCA))
pmid:14556719 complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K48-linked ubiquitination")))
pmid:14556719 complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K63-linked ubiquitination")))
pmid:14556719 complex(GO:"proteasome complex") increases deg(complex(p(HGNC:OAZ1), p(HGNC:ODC1)))
pmid:14556719 complex(GO:"proteasome complex") increases a(CHEBI:peptide)
pmid:14556719 complex(GO:"proteasome complex") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:14556719 complex(GO:"proteasome complex") increases deg(a(CHEBI:"amyloid-beta"))
pmid:22908190 act(complex(GO:"proteasome complex")) negativeCorrelation a(CHEBI:"amyloid-beta")
pmid:14556719 act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging)
pmid:22908190 act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging)
pmid:22908190 act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging)
pmid:14556719 act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:SOD1, var("?"))
pmid:14556719 act(complex(GO:"proteasome complex")) decreases bp(GO:autophagy)
pmid:18930136 act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:autophagy)
pmid:14556719 act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?"))
pmid:22908190 complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(Ub)))
pmid:22908190 complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(UbK48)))
pmid:22908190 act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"paired helical filaments")
pmid:22908190 act(complex(GO:"proteasome complex")) negativeCorrelation a(GO:"neurofibrillary tangle")
pmid:22908190 act(complex(GO:"proteasome complex")) negativeCorrelation complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:22908190 complex(GO:"proteasome complex") increases deg(p(FPLX:PKA, pmod(Ub)))
pmid:22908190 complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT))
pmid:22908190 complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT))
pmid:22908190 act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT)
pmid:30116051 complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT))
pmid:26751493 act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT)
pmid:17954934 act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT))
pmid:24457024 complex(GO:"proteasome complex") regulates complex(a(MESH:Proteins), a(MESH:Ubiquitin))
pmid:18930136 act(complex(GO:"proteasome complex")) decreases path(HBP:Neurodegeneration)
pmid:18930136 act(complex(GO:"proteasome complex")) decreases p(HGNC:SQSTM1)
pmid:17954934 act(complex(GO:"proteasome complex")) isA complex(GO:"proteasome complex")
pmid:17954934 act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1)
pmid:19732809 act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"O-GlcNAcylation")
pmid:19732809 act(complex(GO:"proteasome complex")) positiveCorrelation g(HGNC:OGT)
pmid:26041011 act(complex(GO:"proteasome complex")) decreases a(HBP:"Tau aggregates")
pmid:26692334 act(complex(GO:"proteasome complex")) positiveCorrelation act(p(FPLX:PKA))
pmid:22040696 composite(p(HGNC:HTR3A), p(HGNC:RIC3)) decreases surf(p(HGNC:HTR3A))
pmid:22040696 p(UNIPROT:P34371) increases act(p(FPLX:CHRN))
pmid:22040696 p(FPLX:CHRN, pmod(Ph, Tyr)) decreases act(p(FPLX:CHRN))
pmid:22040696 complex(p(FPLX:CHRN), p(FPLX:SRC)) increases bp(GO:"catecholamine secretion")
pmid:22040696 complex(p(FPLX:CHRN), p(HGNC:FYN)) increases bp(GO:"catecholamine secretion")
pmid:22040696 complex(p(HGNC:CHRNA7), p(HGNC:FYN)) increases act(p(FPLX:PI3K))
pmid:22040696 complex(p(HGNC:CHRNA7), p(HGNC:JAK2)) increases act(p(FPLX:PI3K))
pmid:22040696 p(HGNC:CHRNA7, pmod(Ph, Tyr)) decreases act(p(HGNC:CHRNA7))
pmid:21787755 bp(GO:"maintenance of synapse structure") association a(HBP:"alpha-7-containing nAChR")
pmid:22040696 act(a(MESH:"SNARE Proteins")) increases tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome))
pmid:22040696 act(a(MESH:"SNARE Proteins")) causesNoChange surf(p(HGNC:CHRNA7))
pmid:22040696 p(HGNC:CHRNA7, var("p.Leu335Ala")) decreases surf(p(HGNC:CHRNA7))
pmid:22040696 p(HGNC:CHRNA7, var("p.Leu336Ala")) decreases surf(p(HGNC:CHRNA7))
pmid:22040696 p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases surf(p(HGNC:CHRNA7))
pmid:22040696 r(HGNC:RIC3) positiveCorrelation path(MESH:Schizophrenia)
pmid:22040696 r(HGNC:RIC3) positiveCorrelation path(MESH:"Bipolar Disorder")
pmid:22040696 path(MESH:"Bipolar Disorder") positiveCorrelation r(HGNC:RIC3)
pmid:22040696 path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(chap))
pmid:22040696 bp(GO:"response to ischemia") increases path(MESH:"Renal Insufficiency")
pmid:18174175 complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) increases act(a(HBP:"alpha-3 beta-2 nAChR"))
pmid:26837465 p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle")
pmid:26837465 p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle")
pmid:26837465 p(HGNC:ESR1) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:21787755 bp(GO:"neuron projection maintenance") association a(HBP:"alpha-7-containing nAChR")
pmid:21787755 a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder")
pmid:21787755 a(HBP:AβOs) association path(MESH:"Alzheimer Disease")
pmid:21787755 a(HBP:AβOs) association path(MESH:Epilepsy)
pmid:22908190 a(HBP:AβOs) decreases act(a(GO:synapse))
pmid:22908190 a(HBP:AβOs) decreases bp(GO:"long-term synaptic potentiation")
pmid:22908190 a(HBP:AβOs) decreases bp(GO:learning)
pmid:22908190 a(HBP:AβOs) decreases bp(GO:memory)
pmid:22908190 a(HBP:AβOs) increases bp(GO:"long-term synaptic depression")
pmid:22908190 a(HBP:AβOs) decreases bp(GO:"L-glutamate import")
pmid:22908190 a(HBP:AβOs) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:22908190 a(HBP:AβOs) increases deg(a(MESH:Neurites))
pmid:22908190 a(HBP:AβOs) decreases act(complex(GO:"proteasome complex"))
pmid:28528849 a(HBP:AβOs) decreases a(MESH:"Dendritic Spines")
pmid:21787755 a(HBP:"alpha-4 beta-4 nAChR") association path(MESH:"Tobacco Use Disorder")
pmid:21787755 path(MESH:Seizures) association a(HBP:"alpha-7-containing nAChR")
pmid:21787755 a(HBP:"alpha-6-containing nAChR") association path(MESH:Pleasure)
pmid:21787755 a(HBP:"alpha-6-containing nAChR") association path(MESH:Reward)
pmid:21787755 a(HBP:"alpha-6-containing nAChR") association path(MESH:Affect)
pmid:21787755 a(HBP:"alpha-6-containing nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid"))
pmid:21787755 a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder")
pmid:21787755 a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion")
pmid:21787755 path(MESH:Pleasure) association a(HBP:"alpha-6-containing nAChR")
pmid:21787755 path(MESH:Reward) association a(HBP:"alpha-6-containing nAChR")
pmid:21787755 path(MESH:Reward) association r(HGNC:CHRNA6)
pmid:21787755 path(MESH:Reward) association p(HGNC:CHRNA6)
pmid:28901280 path(MESH:Reward) association p(MESH:"Receptors, Nicotinic")
pmid:21787755 path(MESH:Affect) association a(HBP:"alpha-6-containing nAChR")
pmid:21787755 a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR"))
pmid:21787755 a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR"))
pmid:21787755 a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-3 beta-2 nAChR"))
pmid:21787755 a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-6-containing nAChR"))
pmid:21787755 bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6)
pmid:21787755 bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6)
pmid:28901280 complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases act(a(MESH:"Peripheral Nervous System"))
pmid:28901280 complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(MESH:Sodium), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28901280 complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28901280 complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region"))
pmid:28901280 a(MESH:Acetylcholine) association bp(GO:"cell-cell signaling")
pmid:28901280 a(MESH:Acetylcholine) association bp(HBP:"cell population proliferation")
pmid:28901280 a(MESH:Acetylcholine) association bp(GO:"cell adhesion")
pmid:28901280 a(MESH:Acetylcholine) association bp(MESH:"Cell Movement")
pmid:28901280 a(MESH:Acetylcholine) association bp(GO:"secretion by cell")
pmid:28901280 a(MESH:Acetylcholine) association bp(MESH:"Cell Survival")
pmid:28901280 a(MESH:Acetylcholine) association bp(MESH:Apoptosis)
pmid:28901280 a(MESH:Acetylcholine) association bp(MESH:"Autocrine Communication")
pmid:28901280 a(MESH:Acetylcholine) association bp(MESH:"Paracrine Communication")
pmid:28901280 a(MESH:Acetylcholine) association bp(HBP:"juxtacrine signaling")
pmid:28901280 a(MESH:Acetylcholine) decreases path(MESH:Inflammation)
pmid:28901280 a(MESH:Acetylcholine) increases path(MESH:Neoplasms)
pmid:28901280 a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)))
pmid:28901280 a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9))
pmid:28901280 complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic"), loc(MESH:Brain)) decreases path(MESH:Anxiety)
pmid:28901280 a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))
pmid:28901280 a(MESH:Nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
pmid:28901280 a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))
pmid:28901280 a(MESH:Nicotine) decreases a(MESH:Neurons)
pmid:28901280 a(MESH:Nicotine) decreases p(MESH:"Receptors, Nicotinic")
pmid:28901280 a(MESH:Nicotine) increases bp(GO:"nodal receptor complex assembly")
pmid:28901280 a(MESH:Nicotine) increases act(p(MESH:"Proteasome Endopeptidase Complex"))
pmid:28901280 a(MESH:Nicotine) increases a(MESH:Glutamates)
pmid:28901280 a(MESH:Nicotine) increases a(MESH:Glutamates)
pmid:28901280 a(MESH:Nicotine) increases p(MESH:"Receptors, GABA")
pmid:28901280 a(MESH:Nicotine) decreases p(MESH:"Receptors, GABA")
pmid:28901280 a(MESH:Nicotine) increases bp(GO:"action potential initiation")
pmid:28901280 a(MESH:Nicotine) increases a(MESH:Dopamine)
pmid:28901280 a(MESH:Nicotine) increases a(MESH:Dopamine)
pmid:28901280 a(MESH:Nicotine) increases act(p(HGNC:CHRNA7))
pmid:28901280 a(MESH:Nicotine) decreases act(p(HGNC:CHRNA7))
pmid:28901280 a(MESH:Nicotine) increases p(MESH:"Receptors, N-Methyl-D-Aspartate")
pmid:28901280 a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation")
pmid:28901280 act(a(MESH:Nicotine)) association g(DNSNP:rs16969968)
pmid:28901280 a(MESH:Nicotine) increases path(MESH:Neoplasms)
pmid:28901280 a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)))
pmid:28901280 a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9))
pmid:28901280 complex(a(MESH:"Receptors, Muscarinic"), a(MESH:Acetylcholine)) increases act(a(MESH:"Central Nervous System"))
pmid:28901280 bp(GO:"cell-cell signaling") association a(MESH:Acetylcholine)
pmid:28901280 bp(HBP:"cell population proliferation") association a(MESH:Acetylcholine)
pmid:28901280 bp(HBP:"cell population proliferation") association p(MESH:"Receptors, Nicotinic")
pmid:28901280 bp(MESH:"Cell Movement") association a(MESH:Acetylcholine)
pmid:28901280 bp(GO:"secretion by cell") association a(MESH:Acetylcholine)
pmid:28901280 bp(MESH:Apoptosis) association a(MESH:Acetylcholine)
pmid:28901280 bp(MESH:"Autocrine Communication") association a(MESH:Acetylcholine)
pmid:28901280 bp(MESH:"Paracrine Communication") association a(MESH:Acetylcholine)
pmid:28901280 bp(HBP:"juxtacrine signaling") association a(MESH:Acetylcholine)
pmid:28901280 a(MESH:Erythrocytes) increases a(MESH:Acetylcholine)
pmid:28901280 a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase")
pmid:29626319 a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta"))
pmid:28901280 a(MESH:"Epithelial Cells") increases a(MESH:Acetylcholine)
pmid:28901280 a(MESH:"Epithelial Cells") increases a(MESH:"Choline O-Acetyltransferase")
pmid:28901280 path(MESH:Learning) association p(MESH:"Receptors, Nicotinic")
pmid:28901280 bp(MESH:Analgesia) association p(MESH:"Receptors, Nicotinic")
pmid:28901280 p(HGNC:CHRFAM7A, loc(MESH:Oocytes)) decreases act(p(HGNC:CHRNA7, loc(MESH:Oocytes)))
pmid:28901280 bp(GO:"cell differentiation") association p(MESH:"Receptors, Nicotinic")
pmid:28901280 a(HBP:cytisine) decreases p(MESH:"Receptors, Nicotinic")
pmid:28901280 a(HBP:cytisine) decreases act(a(MESH:Nicotine))
pmid:28901280 a(MESH:Carbachol) decreases p(MESH:"Receptors, Nicotinic")
pmid:28901280 a(MESH:Carbachol) decreases act(a(MESH:Nicotine))
pmid:28901280 a(MESH:Varenicline) decreases p(MESH:"Receptors, Nicotinic")
pmid:28901280 a(MESH:Varenicline) decreases act(a(MESH:Nicotine))
pmid:28901280 a(MESH:Mecamylamine) decreases p(MESH:"Receptors, Nicotinic")
pmid:28901280 a(MESH:Mecamylamine) decreases act(a(MESH:Nicotine))
pmid:28901280 a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons"))
pmid:28901280 a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons"))
pmid:28901280 a(MESH:Glutamates) increases bp(MESH:"Long-Term Potentiation")
pmid:28901280 a(MESH:Glutamates) increases bp(GO:"action potential initiation")
pmid:27796283 bp(MESH:"Long-Term Potentiation") association p(HGNC:CAMKV)
pmid:27041503 bp(MESH:"Long-Term Potentiation") negativeCorrelation bp(GO:"actin filament polymerization")
pmid:27041503 bp(MESH:"Long-Term Potentiation") negativeCorrelation p(HGNC:WWC1)
pmid:27041503 bp(MESH:"Long-Term Potentiation") positiveCorrelation bp(GO:memory)
pmid:28901280 bp(HBP:"habenulo-interpeduncular pathway") increases p(MESH:"Receptors, Nicotinic")
pmid:28901280 bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA3, loc(MESH:"Central Nervous System"))
pmid:28901280 bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNB4, loc(MESH:"Central Nervous System"))
pmid:28901280 bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA5, loc(MESH:"Central Nervous System"))
pmid:28901280 g(DNSNP:rs16969968) association act(a(MESH:Nicotine))
pmid:28901280 p(MGI:Chrna5) regulates act(a(MESH:Nicotine))
pmid:28901280 p(MGI:Chrna5) increases a(MESH:Nicotine)
pmid:28901280 p(MGI:Chrnb4) decreases act(a(MESH:Nicotine))
pmid:28901280 p(MGI:Chrna2) increases a(MESH:Nicotine)
pmid:28901280 a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation")
pmid:28901280 a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement")
pmid:28901280 a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis)
pmid:28901280 p(HBP:"LY6 family") regulates p(MESH:"Receptors, Nicotinic")
pmid:28901280 g(DNSNP:rs1051730) association path(MESH:"Lung Neoplasms")
pmid:28901280 g(DNSNP:rs1051730) association path(MESH:"Tobacco Use Disorder")
pmid:28901280 bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular))
pmid:28901280 a(MESH:Epithelium) regulates a(MESH:Acetylcholine)
pmid:28901280 act(a(MESH:Epithelium)) association p(MGI:Chrna7)
pmid:28901280 a(MESH:Choline) increases act(p(HGNC:CHRNA9))
pmid:28901280 a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))
pmid:28901280 a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9)
pmid:28901280 a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))
pmid:28901280 a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9)
pmid:28901280 path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9)
pmid:28901280 path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5)
pmid:28901280 path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4))
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1))
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:FPR3)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TUBB1)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates act(p(HGNC:LIPA))
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:HIST1H3B)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates p(HGNC:HIST1H3B)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:ABCF3)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:BMP4)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:CDH17)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KDM5D)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KLF1)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:PER1)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AKT1)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AIF1)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Vestibular Diseases")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation bp(MESH:"Body Height")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation path(MESH:"Weight Gain")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Motor Activity")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Motor Activity")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(MESH:"Hand Strength")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange bp(MESH:"Hand Strength")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Recognition (Psychology)")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Autistic Disorder")
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:Smell)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:Smell)
pmid:30106381 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior")
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior")
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior")
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:memory)
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Motor Skills Disorders")
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Brain Injuries")
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(MESH:"Nerve Fibers, Myelinated")
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange p(HGNC:SLC17A7)
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7)
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7)
pmid:30664622 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:SLC17A7)
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:ADNP)
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking")
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Alcohol Drinking")
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking")
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking")
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:saccharin), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular))
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:quinine), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular))
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TFAP2B)
pmid:30008470 p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:TFAP2B)
pmid:30106381 p(HGNC:ADNP) association bp(GO:autophagy)
pmid:30106381 p(HGNC:ADNP) association bp(GO:autophagy)
pmid:30106381 p(HGNC:ADNP) association bp(GO:"cell adhesion")
pmid:30106381 p(HGNC:ADNP) association bp(GO:"immune response")
pmid:30106381 p(HGNC:ADNP) association path(MESH:"Autistic Disorder")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Autistic Disorder")
pmid:30106381 p(HGNC:ADNP) association act(a(GO:synapse))
pmid:30106381 p(HGNC:ADNP) association bp(GO:"nervous system development")
pmid:30106381 p(HGNC:ADNP) association bp(GO:"synapse assembly")
pmid:30106381 p(HGNC:ADNP) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic")
pmid:30106381 p(HGNC:ADNP) regulates bp(GO:"synapse organization")
pmid:30106381 p(HGNC:ADNP) regulates bp(GO:"cell communication")
pmid:30106381 p(HGNC:ADNP) association bp(GO:"AMPA glutamate receptor clustering")
pmid:30106381 p(HGNC:ADNP) association bp(GO:learning)
pmid:30106381 p(HGNC:ADNP) association bp(GO:memory)
pmid:30664622 p(HGNC:ADNP) increases bp(GO:memory)
pmid:30106381 p(HGNC:ADNP) association bp(GO:"social behavior")
pmid:30664622 p(HGNC:ADNP) increases bp(GO:"social behavior")
pmid:30106381 p(HGNC:ADNP) regulates bp(GO:"ion transport")
pmid:30106381 p(HGNC:ADNP) association bp(GO:"vocalization behavior")
pmid:30106381 p(HGNC:ADNP) regulates p(HGNC:APOE)
pmid:30106381 p(HGNC:ADNP) association g(HGNC:"IQCJ-SCHIP1")
pmid:30106381 p(HGNC:ADNP) association p(HGNC:NLGN2)
pmid:30106381 p(HGNC:ADNP) regulates p(HGNC:PAX6)
pmid:30106381 p(HGNC:ADNP) association p(HGNC:WFS1)
pmid:30106381 p(HGNC:ADNP) association path(MESH:Inflammation)
pmid:30106381 p(HGNC:ADNP) association path(MESH:Intelligence)
pmid:30106381 p(HGNC:ADNP) regulates p(HGNC:MTOR)
pmid:30664622 p(HGNC:ADNP) decreases path(MESH:"Motor Skills Disorders")
pmid:30664622 p(HGNC:ADNP) increases a(MESH:"Nerve Fibers, Myelinated")
pmid:30664622 act(p(HGNC:ADNP)) association a(GO:"glutamatergic synapse")
pmid:30664622 p(HGNC:ADNP) increases a(GO:"dendritic spine")
pmid:30664622 act(p(HGNC:ADNP)) association p(HGNC:DLG4)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Intellectual Disability")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Developmental Disabilities")
pmid:29724491 p(HGNC:ADNP) increases bp(GO:"motor behavior")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Muscle Hypotonia")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Muscle Hypertonia")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Language Development Disorders")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:Seizures)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:Epilepsy)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Autism Spectrum Disorder")
pmid:29724491 p(HGNC:ADNP) increases bp(GO:"sensory processing")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Compulsive Behavior")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Mood Disorders")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:Anxiety)
pmid:29724491 p(HGNC:ADNP) increases path(MESH:Morale)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Self-Injurious Behavior")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:Aggression)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Attention Deficit Disorder with Hyperactivity")
pmid:29724491 p(HGNC:ADNP) increases bp(GO:sleep)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:"Malformations of Cortical Development")
pmid:29724491 p(HGNC:ADNP) increases path(MESH:"Vision, Ocular")
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:Hyperopia)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:Strabismus)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:Myopia)
pmid:29724491 p(HGNC:ADNP) decreases path(MESH:Astigmatism)
pmid:27671637 a(GO:"dendritic spine") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27807169 a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2)
pmid:22156579 a(GO:"dendritic spine") negativeCorrelation p(HGNC:MARK4)
pmid:30106381 a(PUBCHEM:9832404) increases a(GO:"dendritic spine")
pmid:30106381 a(PUBCHEM:9832404) increases a(GO:"dendritic spine")
pmid:30106381 a(PUBCHEM:9832404) increases a(GO:"dendritic spine")
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:DLG4)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:DLG4)
pmid:30106381 a(PUBCHEM:9832404) causesNoChange p(HGNC:DLG4)
pmid:30106381 a(PUBCHEM:9832404) increases p(HGNC:DLG4)
pmid:30664622 act(a(PUBCHEM:9832404)) association p(HGNC:DLG4)
pmid:30106381 a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft")
pmid:30106381 a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft")
pmid:30106381 a(PUBCHEM:9832404) increases a(GO:"excitatory synapse")
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:autophagy)
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:"cell adhesion")
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:"immune response")
pmid:30106381 a(PUBCHEM:9832404) association path(MESH:"Autistic Disorder")
pmid:30106381 a(PUBCHEM:9832404) decreases path(MESH:"Autistic Disorder")
pmid:30106381 a(PUBCHEM:9832404) association act(a(GO:synapse))
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:"nervous system development")
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:"synapse assembly")
pmid:30106381 a(PUBCHEM:9832404) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic")
pmid:30106381 a(PUBCHEM:9832404) regulates bp(GO:"synapse organization")
pmid:30106381 a(PUBCHEM:9832404) regulates bp(GO:"cell communication")
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:"AMPA glutamate receptor clustering")
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:learning)
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:memory)
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:"social behavior")
pmid:30106381 a(PUBCHEM:9832404) increases bp(GO:"social behavior")
pmid:30664622 a(PUBCHEM:9832404) increases bp(GO:"social behavior")
pmid:30664622 a(PUBCHEM:9832404) increases bp(GO:"social behavior")
pmid:30106381 a(PUBCHEM:9832404) regulates bp(GO:"ion transport")
pmid:30106381 a(PUBCHEM:9832404) association bp(GO:"vocalization behavior")
pmid:30106381 a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1))
pmid:30106381 a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4))
pmid:30106381 a(PUBCHEM:9832404) increases p(HGNC:FPR3)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:TUBB1)
pmid:30106381 a(PUBCHEM:9832404) association p(HGNC:APOE)
pmid:30106381 a(PUBCHEM:9832404) association g(HGNC:"IQCJ-SCHIP1")
pmid:30106381 a(PUBCHEM:9832404) association p(HGNC:NLGN2)
pmid:30106381 a(PUBCHEM:9832404) association p(HGNC:PAX6)
pmid:30106381 a(PUBCHEM:9832404) regulates p(HGNC:WFS1)
pmid:30106381 a(PUBCHEM:9832404) increases p(HGNC:HIST1H3B)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:ABCF3)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:BMP4)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:CDH17)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:KDM5D)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:KLF1)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:PER1)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:AKT1)
pmid:30106381 a(PUBCHEM:9832404) decreases p(HGNC:AIF1)
pmid:30106381 a(PUBCHEM:9832404) regulates p(HGNC:MTOR)
pmid:30106381 a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance")
pmid:30106381 a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance")
pmid:30106381 a(PUBCHEM:9832404) decreases path(MESH:"Vestibular Diseases")
pmid:30106381 a(PUBCHEM:9832404) increases path(MESH:"Motor Activity")
pmid:30106381 a(PUBCHEM:9832404) increases bp(MESH:"Hand Strength")
pmid:30106381 a(PUBCHEM:9832404) increases path(MESH:"Recognition (Psychology)")
pmid:30106381 a(PUBCHEM:9832404) increases path(MESH:Smell)
pmid:30664622 a(PUBCHEM:9832404) causesNoChange bp(GO:behavior)
pmid:30664622 a(PUBCHEM:9832404) decreases path(MESH:"Motor Skills Disorders")
pmid:30664622 a(PUBCHEM:9832404) decreases path(HBP:Excitotoxicity)
pmid:30664622 act(a(PUBCHEM:9832404)) association a(GO:"glutamatergic synapse")
pmid:30664622 a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7)
pmid:30664622 a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7)
pmid:30664622 a(PUBCHEM:9832404) increases p(HGNC:SLC17A7)
pmid:30664622 a(PUBCHEM:9832404) increases r(HGNC:SLC17A7)
pmid:30664622 a(PUBCHEM:9832404) decreases r(HGNC:SLC17A7)
pmid:30008470 a(PUBCHEM:9832404) increases complex(a(GO:microtubule), p(HGNC:ADNP))
pmid:30008470 a(PUBCHEM:9832404) increases act(p(HGNC:ADNP))
pmid:30106381 p(HGNC:DLG4) regulates act(p(HGNC:ADNP))
pmid:30664622 p(HGNC:DLG4) association act(p(HGNC:ADNP))
pmid:30106381 p(HGNC:DLG4) regulates act(a(PUBCHEM:9832404))
pmid:30664622 p(HGNC:DLG4) association act(a(PUBCHEM:9832404))
pmid:30106381 p(HGNC:DLG4) association bp(GO:"regulation of synaptic plasticity")
pmid:24760868 p(HGNC:DLG4, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:26751493 p(HGNC:DLG4) association p(HBP:"projection domain")
pmid:26751493 p(HGNC:DLG4) association a(HBP:"projection domain")
pmid:30106381 composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases a(GO:"dendritic spine")
pmid:30664622 composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell)
pmid:30664622 composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell)
pmid:30008470 composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Alcohol Drinking")
pmid:30106381 bp(GO:"nervous system development") association p(HGNC:ADNP)
pmid:30106381 bp(GO:"nervous system development") association a(PUBCHEM:9832404)
pmid:30106381 bp(GO:"AMPA glutamate receptor clustering") association p(HGNC:ADNP)
pmid:30106381 bp(GO:"AMPA glutamate receptor clustering") association a(PUBCHEM:9832404)
pmid:30106381 bp(GO:"social behavior") association p(HGNC:ADNP)
pmid:30106381 bp(GO:"social behavior") association a(PUBCHEM:9832404)
pmid:30106381 bp(GO:"vocalization behavior") association p(HGNC:ADNP)
pmid:30106381 bp(GO:"vocalization behavior") association a(PUBCHEM:9832404)
pmid:21882945 p(HGNC:AKT1) association complex(p(FPLX:HSP90), p(HGNC:STUB1))
pmid:21882945 p(HGNC:AKT1) negativeCorrelation deg(p(HGNC:MAPT))
pmid:21367866 act(p(HGNC:AKT1), ma(kin)) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37))
pmid:30106381 p(HGNC:AKT1, var("?")) increases path(MESH:"Proteus Syndrome")
pmid:30106381 g(HGNC:"IQCJ-SCHIP1") increases bp(GO:"calcium-mediated signaling")
pmid:30106381 g(HGNC:"IQCJ-SCHIP1") increases bp(GO:"action potential")
pmid:30106381 g(HGNC:"IQCJ-SCHIP1") increases bp(MESH:"Neuronal Outgrowth")
pmid:30106381 g(HGNC:"IQCJ-SCHIP1") association p(HGNC:ADNP)
pmid:30106381 g(HGNC:"IQCJ-SCHIP1") association a(PUBCHEM:9832404)
pmid:30106381 p(HGNC:LIPA) increases bp(GO:"lipid metabolic process")
pmid:22142809 p(HGNC:LIPA) negativeCorrelation p(HBP:RAC1b)
pmid:30106381 p(HGNC:NLGN2) association a(PUBCHEM:9832404)
pmid:30106381 p(HGNC:NLGN2) association p(HGNC:ADNP)
pmid:30106381 p(HGNC:PAX6) association a(PUBCHEM:9832404)
pmid:30106381 p(HGNC:WFS1) association path(HBP:Neurodegeneration)
pmid:30106381 p(HGNC:WFS1) regulates bp(GO:"cellular calcium ion homeostasis")
pmid:30106381 p(HGNC:WFS1) association p(HGNC:ADNP)
pmid:30106381 path(MESH:Intelligence) association p(HGNC:ADNP)
pmid:26010758 p(HGNC:AIF1) positiveCorrelation bp(GO:"microglial cell activation")
pmid:30106381 p(HGNC:MTOR) association bp(GO:translation)
pmid:30106381 p(HGNC:MTOR) association bp(GO:autophagy)
pmid:29758300 p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy)
pmid:22908190 p(HGNC:MTOR) regulates bp(GO:autophagy)
pmid:30106381 p(HGNC:MTOR) association a(GO:"actin cytoskeleton")
pmid:29758300 p(HGNC:MTOR) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:30106381 bp(GO:translation) association p(HGNC:MTOR)
pmid:30106381 a(GO:"actin cytoskeleton") association p(HGNC:MTOR)
pmid:30106381 bp(MESH:"Body Height") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))
pmid:30106381 path(MESH:"Weight Gain") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))
pmid:28391535 path(MESH:"Motor Activity") negativeCorrelation a(CHEBI:nicotine)
pmid:30664622 path(MESH:Smell) regulates bp(GO:"social behavior")
pmid:30664622 a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain))
pmid:30664622 a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cell Body"))
pmid:30664622 a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain))
pmid:30664622 a(CHEBI:chlorobutanol) causesNoChange a(MESH:"Blood-Brain Barrier")
pmid:30664622 a(CHEBI:chlorobutanol) increases bp(GO:"social behavior")
pmid:30664622 a(CHEBI:chlorobutanol) causesNoChange path(MESH:Smell)
pmid:30664622 a(CHEBI:chlorobutanol) decreases path(MESH:Smell)
pmid:30664622 a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain))
pmid:30664622 a(CHEBI:"Evans blue") increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(GO:"cell periphery"))
pmid:30664622 a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain))
pmid:26195256 a(MESH:"Blood-Brain Barrier") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))
pmid:26195256 act(a(MESH:"Blood-Brain Barrier")) association p(HGNC:PPIA)
pmid:30664622 composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:memory)
pmid:30664622 composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:"social behavior")
pmid:30664622 composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases a(MESH:"Nerve Fibers, Myelinated")
pmid:30664622 composite(a(PUBCHEM:59557), a(PUBCHEM:9832404)) decreases bp(GO:"social behavior")
pmid:30664622 composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell)
pmid:30664622 composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell)
pmid:30664622 p(HGNC:SLC17A7) regulates bp(GO:"glutamate homeostasis")
pmid:30664622 p(HGNC:SLC17A7) increases bp(GO:"L-glutamate import")
pmid:29724491 p(HGNC:ADNP, frag("1_719")) decreases bp(GO:"walking behavior")
pmid:28167836 path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Arg205del")
pmid:28167836 path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Glu239del")
pmid:30008470 path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP)
pmid:30008470 path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP)
pmid:30008470 path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP)
pmid:30008470 path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP)
pmid:30008470 path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP)
pmid:30008470 path(MESH:"Alcohol Drinking") decreases p(HGNC:ADNP)
pmid:30008470 path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP)
pmid:30008470 path(MESH:"Alcohol Drinking") negativeCorrelation g(HGNC:ADNP)
pmid:30008470 path(MESH:"Alcohol Drinking") decreases p(HGNC:TFAP2B)
pmid:30008470 g(HGNC:ADNP) negativeCorrelation path(MESH:"Alcohol Drinking")
pmid:14556719 a(GO:microtubule) association p(HGNC:MAPT)
pmid:26631930 a(GO:microtubule) negativeCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines"))
pmid:18930136 a(GO:microtubule) increases bp(GO:"autophagosome-lysosome fusion")
pmid:8282104 a(GO:microtubule) association p(HGNC:CDK5)
pmid:8282104 a(GO:microtubule) association p(HGNC:PRKACA)
pmid:8282104 a(GO:microtubule) association p(FPLX:ERK)
pmid:8282104 a(GO:microtubule) association p(FPLX:GSK3)
pmid:23487739 a(GO:microtubule) negativeCorrelation act(p(HGNC:HDAC6))
pmid:22807490 path(MESH:"Hashimoto Disease") association path(MESH:Smoking)
pmid:22807490 p(HGNC:TPO) negativeCorrelation path(MESH:Smoking)
pmid:22807490 path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL1R2)
pmid:22807490 a(CHEBI:lipopolysaccharide) increases bp(GO:"macrophage activation")
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph))
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Il6)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Il6)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Il6)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf)
pmid:23178521 a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(Ph))
pmid:21958873 a(PUBCHEM:71311633) causesNoChange a(CHEBI:"amyloid-beta")
pmid:21958873 a(PUBCHEM:71311633) increases act(a(MESH:"Receptors, Nicotinic"))
pmid:21958873 a(PUBCHEM:56972222) causesNoChange a(CHEBI:"amyloid-beta")
pmid:21958873 a(PUBCHEM:56972222) increases act(a(MESH:"Receptors, Nicotinic"))
pmid:21958873 a(PUBCHEM:11957537) causesNoChange a(CHEBI:"amyloid-beta")
pmid:21958873 a(PUBCHEM:11957537) decreases act(a(MESH:"Receptors, Nicotinic"))
pmid:23178521 a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph))
pmid:23178521 a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3))
pmid:23178521 a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(Ph))
pmid:23178521 composite(a(CHEBI:Anatabine), a(MESH:Blood)) decreases p(HGNC:IL1B)
pmid:23178521 composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) decreases p(HGNC:IL1B)
pmid:23383175 p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis)
pmid:23383175 p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis)
pmid:23383175 p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis)
pmid:23178521 composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b)
pmid:23178521 composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b)
pmid:23178521 composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf)
pmid:23178521 composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf)
pmid:23178521 composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf)
pmid:23178521 composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6)
pmid:23178521 composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6)
pmid:23383175 p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis)
pmid:23383175 p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis)
pmid:23383175 p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis)
pmid:23383175 p(MGI:Stat3, pmod(Ph)) association path(MESH:"Neurologic Manifestations")
pmid:23383175 p(MGI:Stat3, pmod(Ph)) positiveCorrelation p(MGI:Rela, pmod(Ph))
pmid:23383175 p(MGI:Stat3) regulates bp(GO:"cytokine production")
pmid:23383175 path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine)
pmid:23383175 path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b)
pmid:23383175 path(MESH:Encephalomyelitis) increases p(MGI:Il1b)
pmid:23383175 path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng)
pmid:23383175 path(MESH:Encephalomyelitis) increases p(MGI:Ifng)
pmid:23383175 path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf)
pmid:23383175 path(MESH:Encephalomyelitis) increases p(MGI:Tnf)
pmid:23383175 path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6)
pmid:23383175 path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a)
pmid:23383175 path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph))
pmid:23383175 path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph))
pmid:23383175 path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph))
pmid:23383175 path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph))
pmid:23383175 path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph))
pmid:23383175 path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph))
pmid:23383175 path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph))
pmid:23383175 path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph))
pmid:23383175 path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis)
pmid:23383175 path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis)
pmid:23383175 path(MESH:Encephalomyelitis) increases bp(HBP:Microgliosis)
pmid:23383175 path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord"))
pmid:23383175 path(MESH:Encephalomyelitis) increases a(MESH:Microglia)
pmid:23383175 path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath")
pmid:23383175 p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis)
pmid:23383175 p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis)
pmid:23383175 p(MGI:Rela, pmod(Ph)) positiveCorrelation p(MGI:Stat3, pmod(Ph))
pmid:23383175 p(MGI:Rela) regulates bp(GO:"cytokine production")
pmid:23383175 path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(Ph))
pmid:23383175 bp(HBP:Astrogliosis) negativeCorrelation a(GO:"myelin sheath")
pmid:23383175 bp(HBP:Microgliosis) negativeCorrelation a(GO:"myelin sheath")
pmid:23383175 a(GO:"myelin sheath") positiveCorrelation a(CHEBI:Anatabine)
pmid:23383175 a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes)
pmid:23383175 a(GO:"myelin sheath") negativeCorrelation a(MESH:Microglia)
pmid:23383175 a(GO:"myelin sheath") negativeCorrelation bp(HBP:Astrogliosis)
pmid:23383175 a(GO:"myelin sheath") negativeCorrelation bp(HBP:Microgliosis)
pmid:12428809 p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) association path(MESH:"Alzheimer Disease")
pmid:21882945 p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29191965 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:30145931 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(HBP:"amyloid-beta oligomers")
pmid:28784767 p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8")
pmid:18239272 p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8")
pmid:22817713 p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau aggregates")
pmid:22817713 p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau oligomers")
pmid:22486774 p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(HBP:"Tau oligomers")
pmid:14612456 p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(HGNC:MAPT, pmod(Ph))
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(RGD:Mapt, pmod(Ph))
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 202)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT))
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:FKBP5)
pmid:21367866 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:CDC37)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(FPLX:PKA)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202)))
pmid:25331948 p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo a(HBP:"Tau epitope, CP13")
pmid:26118667 p(HGNC:MAPT, pmod(Ph, Ser, 202)) negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:19459590 p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo p(HBP:"Tau epitope, CP13")
pmid:22833681 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation"))
pmid:24406748 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser"))
pmid:23294633 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:22002427 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*"))
pmid:22002427 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:22253473 p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(GO:"neurofibrillary tangle")
pmid:16464864 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(CHEBI:"okadaic acid")
pmid:16464864 p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340))
pmid:24653673 p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT))
pmid:24653673 p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:17403556 p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22253473 p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")))
pmid:24653673 p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")))
pmid:10391244 p(HGNC:MAPT, pmod(Ph, Thr, 231)) association p(HGNC:PIN1, frag("5_39"))
pmid:10391244 p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation act(p(HGNC:MAPT))
pmid:21367866 p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(HGNC:CDC37)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(FPLX:PKA)
pmid:23948915 p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation bp(GO:"apoptotic process")
pmid:26118667 p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:22833681 p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo a(HBP:"Tau epitope, AT180")
pmid:19623258 p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo p(HBP:"Tau epitope, AT180")
pmid:22926167 p(HGNC:MAPT, pmod(Ph, Thr, 231)) increases a(HBP:"Tau aggregates")
pmid:27574109 a(HBP:"Tau oligomers") association a(HBP:pretangles)
pmid:27574109 a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage I")
pmid:27574109 a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage II")
pmid:27574109 a(HBP:"Tau oligomers") association a(MESH:"Neurofibrillary Tangles")
pmid:27574109 a(HBP:"Tau oligomers") association a(HBP:"Corticobasal Degeneration")
pmid:27574109 a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration")
pmid:27574109 a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration")
pmid:27574109 a(HBP:"Tau oligomers") association a(GO:"Pick body")
pmid:27574109 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies)
pmid:29686391 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies)
pmid:28420982 a(HBP:"Tau oligomers") increases path(MESH:Tauopathies)
pmid:28420982 a(HBP:"Tau oligomers") increases path(MESH:Tauopathies)
pmid:27574109 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27574109 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25887395 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28420982 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27574109 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:27574109 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:28528849 a(HBP:"Tau oligomers") decreases bp(GO:"long-term synaptic potentiation")
pmid:28528849 a(HBP:"Tau oligomers") decreases bp(GO:memory)
pmid:28420982 a(HBP:"Tau oligomers") decreases bp(GO:memory)
pmid:29191965 a(HBP:"Tau oligomers") decreases a(MESH:Neurons)
pmid:29686391 a(HBP:"Tau oligomers") positiveCorrelation bp(HBP:neurotoxicity)
pmid:22817713 a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity)
pmid:22817713 a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity)
pmid:29686391 a(HBP:"Tau oligomers") positiveCorrelation tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau oligomers")
pmid:28420982 a(HBP:"Tau oligomers") increases path(MESH:Disease)
pmid:28420982 a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration)
pmid:28420982 a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration)
pmid:22817713 a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration)
pmid:28420982 a(HBP:"Tau oligomers") increases path(MESH:"Brain Injuries, Traumatic")
pmid:28420982 a(HBP:"Tau oligomers") decreases a(GO:synapse)
pmid:22486774 a(HBP:"Tau oligomers") partOf a(GO:synapse)
pmid:28420982 a(HBP:"Tau oligomers") increases a(HBP:"granular tau oligomers")
pmid:28420982 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:26631930 a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:28420982 a(HBP:"Tau oligomers") decreases bp(GO:cognition)
pmid:28420982 a(HBP:"Tau oligomers") decreases bp(GO:"mitochondrion organization")
pmid:28420982 a(HBP:"Tau oligomers") decreases bp(GO:"maintenance of synapse structure")
pmid:28420982 a(HBP:"Tau oligomers") increases tloc(p(HGNC:MAPT), fromLoc(GO:"neuron part"), toLoc(GO:"neuron part"))
pmid:28420982 a(HBP:"Tau oligomers") increases a(HBP:"Tau annular protofibrils")
pmid:28420982 a(HBP:"Tau oligomers") decreases bp(MESH:"Cell Survival")
pmid:28420982 a(HBP:"Tau oligomers") association p(HGNC:PRNP)
pmid:28420982 a(HBP:"Tau oligomers") decreases act(a(GO:microtubule))
pmid:28420982 a(HBP:"Tau oligomers") decreases a(MESH:"Electron Transport Complex I")
pmid:28420982 a(HBP:"Tau oligomers") decreases act(a(MESH:"Electron Transport Complex I"))
pmid:28420982 a(HBP:"Tau oligomers") decreases bp(GO:"ATP synthesis coupled proton transport")
pmid:28420982 a(HBP:"Tau oligomers") increases act(p(HGNC:CASP9))
pmid:28420982 a(HBP:"Tau oligomers") increases sec(p(HGNC:CYCS))
pmid:26631930 a(HBP:"Tau oligomers") increases path(HBP:Neurodegeneration)
pmid:26631930 a(HBP:"Tau oligomers") decreases a(MESH:"Dendritic Spines")
pmid:22817713 a(HBP:"Tau oligomers") increases a(HBP:"Tau aggregates")
pmid:22817713 a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:22817713 a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:22817713 a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:26671985 act(a(HBP:"Tau oligomers")) increases a(HBP:neurotoxicity)
pmid:26671985 act(a(HBP:"Tau oligomers")) decreases act(complex(GO:axon))
pmid:26671985 act(a(HBP:"Tau oligomers")) positiveCorrelation p(HBP:"phosphatase-activating domain")
pmid:27716675 a(HBP:"Tau oligomers") positiveCorrelation a(HBP:neuroinflammation)
pmid:27716675 a(HBP:"Tau oligomers") increases a(HBP:"Pathological Tau Spreading")
pmid:22299660 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28420982 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26458742 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28420982 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:14612456 p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(HGNC:MAPT, pmod(Ph))
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(RGD:Mapt, pmod(Ph))
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 396)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT))
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:FKBP5)
pmid:21367866 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:CDC37)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(FPLX:PKA)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Ser, 396)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396)))
pmid:22156579 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(HBP:"Tau epitope, PHF1")
pmid:23948915 p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation bp(GO:"apoptotic process")
pmid:28176663 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose")
pmid:22833681 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation"))
pmid:29844403 p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation act(p(HGNC:GSK3B))
pmid:22299660 p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26458742 p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24760868 p(HGNC:MAPT, pmod(Ph, Ser, 404)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines"))
pmid:14612456 p(HGNC:MAPT, pmod(Ph, Ser, 404)) isA p(HGNC:MAPT, pmod(Ph))
pmid:21367866 p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation p(HGNC:CDC37)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Ser, 404)) negativeCorrelation p(FPLX:PKA)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404)))
pmid:11943212 p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf p(HBP:"Tau epitope, AD2")
pmid:22156579 p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation a(HBP:"Tau epitope, PHF1")
DOI:10.4172/2168-975X.1000126 p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B))
pmid:25331948 p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B))
pmid:24183963 p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin))
pmid:29121589 p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin))
pmid:29844403 p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B))
pmid:21734277 p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B))
pmid:25331948 p(HGNC:GSK3B, pmod(Ph, Ser, 9)) negativeCorrelation act(p(HGNC:SYK))
DOI:10.4172/2168-975X.1000126 p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT))
pmid:23454242 p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT))
pmid:29121589 p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT))
pmid:29121589 p(FPLX:AKT, pmod(Ph, Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate")
pmid:28391535 sec(a(CHEBI:adrenaline)) increases sec(a(CHEBI:glucose))
pmid:28391535 sec(a(CHEBI:adrenaline)) increases path(MESH:"Blood Pressure")
pmid:28391535 sec(a(CHEBI:adrenaline)) increases bp(GO:"cellular respiration")
pmid:28391535 sec(a(CHEBI:adrenaline)) increases bp(MESH:"Heart Rate")
pmid:22908190 a(CHEBI:"insulin (human)") regulates p(HGNC:MTOR)
pmid:28391535 a(CHEBI:"(S)-nicotine") increases path(MESH:Death)
pmid:28391535 a(CHEBI:"(R)-nicotine") increases path(MESH:Death)
pmid:28391535 a(MESH:Liver) increases bp(GO:"nicotine metabolic process")
pmid:29626319 a(MESH:Liver) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(MESH:Liver) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(MESH:Liver) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(MESH:Liver) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:29626319 a(MESH:Liver) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42")
pmid:28391535 bp(GO:"nicotine metabolic process") increases a(CHEBI:"(-)-cotinine")
pmid:28391535 bp(GO:"nicotine metabolic process") increases a(CHEBI:nornicotine)
pmid:28391535 a(MESH:Lung) increases bp(GO:"nicotine metabolic process")
pmid:26195256 path(MESH:Hypertension) association path(MESH:"Alzheimer Disease")
pmid:28391535 a(CHEBI:Hexamethonium) negativeCorrelation act(a(CHEBI:nicotine))
pmid:28391535 a(CHEBI:"(-)-lobeline") increases complex(a(CHEBI:"(-)-lobeline"), a(MESH:"nicotinic receptor alpha4beta2"))
pmid:28391535 a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:nicotine))
pmid:28391535 a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:methamphetamine))
pmid:19165623 complex(a(CHEBI:"1-methylpyrrolinium"), a(CHEBI:"nicotinic acid")) increases a(CHEBI:nicotine)
pmid:19165623 a(CHEBI:arginine) increases a(CHEBI:"1-methylpyrrolinium")
pmid:19165623 a(CHEBI:ornithine) increases a(CHEBI:"1-methylpyrrolinium")
pmid:19165623 a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine)
pmid:19165623 a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine)
pmid:19165623 a(UNIPROT:Q9SEH4) increases rxn(reactants(a(CHEBI:arginine), a(CHEBI:ornithine)), products(a(CHEBI:"1-methylpyrrolinium")))
pmid:19165623 a(UNIPROT:Q9SEH4) decreases a(CHEBI:Anatabine)
pmid:19165623 p(HGNC:QPRT) increases rxn(reactants(a(CHEBI:"quinolinic acid")), products(a(CHEBI:"nicotinic acid")))
pmid:19165623 p(HGNC:QPRT) regulates rxn(reactants(a(CHEBI:"nicotinic acid")), products(a(CHEBI:Anatabine)))
pmid:19165623 p(HGNC:QPRT) increases a(CHEBI:Anatabine)
pmid:19165623 p(HGNC:QPRT) increases a(CHEBI:nicotine)
pmid:22020111 a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2))
pmid:22020111 act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases")
pmid:22020111 act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting")
pmid:24563850 p(HGNC:NFE2L2) increases bp(HBP:Proteostasis)
pmid:29121589 p(HGNC:NFE2L2) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2))
pmid:29121589 p(HGNC:NFE2L2) positiveCorrelation p(FPLX:AKT)
pmid:24355211 p(HGNC:NFE2L2) increases p(ECCODE:"2.5.1.18")
pmid:22020111 a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:NFE2L2)
pmid:22020111 a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:SIRT1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:SLC7A11)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:AKR1B10)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:PTGR1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:HMOX1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:HMOX1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:HMOX1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:AIFM2)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:OSGIN1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:GPX3)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:SQSTM1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:HSPB8)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:TNFSF9)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CTNNB1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:DHFR)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:DHFR)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:EDN1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:ITGB3)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:MKI67)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:MMP11)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:MMP14)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:MMP2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PDE7A)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PDE7B)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PLAU)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PTGS1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PTGS1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:SCARB1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TUBB3)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TUBB3)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TUBB3)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:NR3C1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:NR3C1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:PPARA)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:PPARA)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:EGR1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:PTGS2)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:PTGS2)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:SOAT1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:ACLY)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:ACLY)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:ANTXR1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:C20orf27)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CCNA2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CHAF1A)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:EFCAB11)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:FEN1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:GINS2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:MCM10)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:MCM4)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:RNASEH2A)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:SLIT2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:SPC25)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TFRC)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TK1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TMEM97)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TRIP13)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TUBB)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TUBB)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TYMS)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TYMS)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:UBA1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:UNG)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:UNG)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:VRK1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:ABCD3)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:GLRX2)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:GLRX2)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:MICB)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:NQO1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:NQO1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:NQO1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:AGRN)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:ANP32A)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:BAX)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:BCHE)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:BGN)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:BRCA1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CADPS2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CAPN1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CCNB1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CDK1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CDK2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CDKN2A)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:CXCR4)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:EIF4EBP1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:FOLH1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:HOMER1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:HRH1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:IGF2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:IGFBP2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:LDLR)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:MAOA)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:NEFH)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:NPDC1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:NRGN)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PREP)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PROS1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:SELENBP1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TAGLN)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:TGFB1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:VKORC1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:CANX)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:GCNT2)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:IDE)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:MMP1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:SLC6A6)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:SYVN1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:TSHZ1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:TXN)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:ATAD2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:BECN1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:DHCR24)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:FGF2)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:HTRA1)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PRKCE)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:PRKDC)
pmid:22020111 a(PUBCHEM:135316034) decreases p(HGNC:SCD)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:ATP1A1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:CTSD)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:GLRX)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:GLRX)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:IL6R)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:NPTX1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:PHF1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:PRKCD)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:RANBP9)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:SOD1)
pmid:22020111 a(PUBCHEM:135316034) increases p(HGNC:SOD1)
pmid:22020111 a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2))
pmid:22020111 a(PUBCHEM:400769) increases bp(GO:"glomerular filtration")
pmid:22020111 a(PUBCHEM:400769) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting")
pmid:22020111 a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2))
pmid:22020111 a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2))
pmid:22020111 a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2))
pmid:22020111 a(CHEBI:"dimethyl fumarate") causesNoChange act(p(HGNC:NFE2L2))
pmid:22020111 a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2))
pmid:29121589 a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:ERK))
pmid:29121589 a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:p38))
pmid:29121589 a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(Ph, Ser, 473))
pmid:29121589 a(CHEBI:"dimethyl fumarate") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:29121589 a(CHEBI:"dimethyl fumarate") decreases p(HGNC:MAPT, pmod(Ph))
pmid:29121589 a(CHEBI:"dimethyl fumarate") negativeCorrelation p(HGNC:DPYSL2, pmod(Ph))
pmid:29121589 a(CHEBI:"dimethyl fumarate") decreases a(HBP:Astrogliosis)
pmid:29121589 a(CHEBI:"dimethyl fumarate") decreases a(HBP:Microgliosis)
pmid:29121589 a(CHEBI:"dimethyl fumarate") decreases r(MGI:Il1b)
pmid:29121589 a(CHEBI:"dimethyl fumarate") decreases r(MGI:Nos2)
pmid:29121589 a(CHEBI:"dimethyl fumarate") decreases bp(GO:"inflammatory response")
pmid:22020111 p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis")
pmid:22020111 p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:22020111 p(HGNC:AKR1B10) increases bp(GO:detoxification)
pmid:22020111 p(HGNC:AKR1B10) decreases a(PUBCHEM:5283344)
pmid:22020111 p(HGNC:PTGR1) decreases act(a(MESH:Prostaglandins))
pmid:22020111 p(HGNC:PTGR1) decreases act(a(MESH:Eicosanoids))
pmid:22020111 p(HGNC:AIFM2) negativeCorrelation path(MESH:Neoplasms)
pmid:22020111 p(HGNC:GPX3) negativeCorrelation path(MESH:Neoplasms)
pmid:22020111 p(HGNC:SQSTM1) increases bp(GO:autophagy)
pmid:22908190 p(HGNC:SQSTM1) increases bp(GO:autophagy)
pmid:18930136 p(HGNC:SQSTM1) regulates bp(GO:autophagy)
pmid:18930136 p(HGNC:SQSTM1) increases bp(GO:autophagy)
pmid:18930136 p(HGNC:SQSTM1) increases bp(GO:autophagy)
pmid:22020111 p(HGNC:SQSTM1) decreases bp(GO:"stress-induced premature senescence")
pmid:29758300 p(HGNC:SQSTM1) increases deg(p(HGNC:MAPT))
pmid:29758300 p(HGNC:SQSTM1) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:29758300 p(HGNC:SQSTM1) increases p(HGNC:SYP)
pmid:29758300 p(HGNC:SQSTM1) regulates bp(GO:"short-term memory")
pmid:22908190 p(HGNC:SQSTM1) association bp(GO:"proteasomal protein catabolic process")
pmid:18930136 p(HGNC:SQSTM1) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:18930136 p(HGNC:SQSTM1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:18930136 p(HGNC:SQSTM1) regulates a(GO:aggresome)
pmid:18930136 p(HGNC:SQSTM1) association a(GO:"Lewy body")
pmid:18930136 p(HGNC:SQSTM1) association a(GO:"neurofibrillary tangle")
pmid:18930136 p(HGNC:SQSTM1) association p(HGNC:SOD1, var("?"))
pmid:18930136 p(HGNC:SQSTM1) increases deg(p(MESH:Proteins, pmod(Ub)))
pmid:18930136 p(HGNC:SQSTM1) increases bp(GO:"ubiquitin-dependent protein catabolic process")
pmid:30116051 p(HGNC:SQSTM1) association path(MESH:"Frontotemporal Dementia")
pmid:30116051 p(HGNC:SQSTM1) association path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:22020111 p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8))
pmid:27491084 p(HGNC:HSPB8) association a(HBP:"amyloid-beta aggregates")
pmid:24563850 p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy")
pmid:24563850 p(HGNC:HSPB8) association p(HGNC:EIF2A)
pmid:22020111 complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy)
pmid:22020111 complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(HBP:"protein aggregates"))
pmid:23746257 p(HGNC:BAG3) increases bp(GO:macroautophagy)
pmid:25036637 p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8))
pmid:25036637 p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB1))
pmid:25036637 p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:HSPB1))
pmid:25036637 p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSF1))
pmid:25036637 p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:DCP1B))
pmid:29626319 p(HGNC:BAG3) increases deg(p(HGNC:MAPT))
pmid:22020111 a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22020111 a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease")
pmid:22020111 a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:29758300 a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Neurodegenerative Diseases")
pmid:14556719 a(HBP:"protein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:22020111 p(HGNC:TNFSF9) increases act(a(MESH:"Dendritic Cells"))
pmid:22020111 p(HGNC:TNFSF9) increases bp(GO:"T cell activation")
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:CTNNB1)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:DHFR)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:EDN1)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:ITGB3)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:MKI67)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:MMP11)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:MMP14)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:MMP2)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:PDE7A)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:PDE7B)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:PLAU)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:PTGS1)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:SCARB1)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:TUBB3)
pmid:22020111 path(MESH:Atherosclerosis) decreases p(HGNC:NR3C1)
pmid:22020111 path(MESH:Atherosclerosis) decreases p(HGNC:PPARA)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:EGR1)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:PTGS2)
pmid:22020111 path(MESH:Atherosclerosis) increases p(HGNC:SOAT1)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:ACLY)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:ANTXR1)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:C20orf27)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:CCNA2)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:CHAF1A)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:DHFR)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:EFCAB11)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:FEN1)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:GINS2)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM10)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM4)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:RNASEH2A)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:SLIT2)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:SPC25)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:TFRC)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:TK1)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:TMEM97)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:TRIP13)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB3)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:TYMS)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:UBA1)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:UNG)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:VRK1)
pmid:22020111 path(MESH:"Colorectal Neoplasms") decreases p(HGNC:ABCD3)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:GLRX2)
pmid:22020111 path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:GLRX2)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:MICB)
pmid:22020111 path(MESH:"Colorectal Neoplasms") increases p(HGNC:NQO1)
pmid:22020111 path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:NQO1)
pmid:22020111 path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress")
pmid:25036637 p(HGNC:MCM4) increases bp(GO:"DNA replication initiation")
pmid:25036637 p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site")
pmid:14556719 act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:18930136 p(HGNC:UBA1) increases bp(GO:autophagy)
pmid:18930136 p(HGNC:UBA1) increases bp(GO:"protein ubiquitination")
pmid:29626319 p(HGNC:UBA1) increases deg(a(MESH:Proteins))
pmid:25673844 p(HGNC:VRK1) isA p(HBP:"CK1 superfamily")
pmid:22020111 p(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms")
pmid:22020111 p(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms")
pmid:22020111 p(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(HGNC:ANP32A) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:ANP32A) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CA))
pmid:24653673 p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CB))
pmid:24653673 p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(HGNC:ANP32A) decreases act(p(FPLX:PPP2))
pmid:30116051 p(HGNC:CAPN1) decreases bp(GO:autophagy)
pmid:30116051 p(HGNC:CAPN1) decreases deg(p(HGNC:HTT, var("?")))
pmid:12428809 p(HGNC:CDK1) increases p(HGNC:MAPT, pmod(Ph))
pmid:10391244 act(p(HGNC:CDK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:10391244 p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle")
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235))
pmid:22072628 act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:8282104 p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:22072628 p(HGNC:CDK2) increases a(HBP:"Tau epitope, AT180")
pmid:22072628 act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 212))
pmid:22072628 act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 217))
pmid:29758300 p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:BECN1) decreases a(MESH:"Amyloid beta-Peptides")
pmid:29758300 p(HGNC:BECN1) association bp(GO:macroautophagy)
pmid:29758300 p(HGNC:BECN1) association bp(GO:endocytosis)
pmid:29758300 p(HGNC:BECN1) increases bp(GO:phagocytosis)
pmid:30116051 act(p(HGNC:BECN1)) increases bp(GO:"autophagosome assembly")
pmid:27260836 p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM)
pmid:24027553 act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT))
pmid:29626319 p(HGNC:HTRA1) increases deg(p(HGNC:MAPT))
pmid:24027553 p(HGNC:HTRA1) association bp(HBP:"APP processing")
pmid:24027553 act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins))
pmid:24027553 act(p(HGNC:HTRA1)) association act(a(MESH:Microtubules))
pmid:24027553 act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau fibrils"))
pmid:24027553 act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau aggregates"))
pmid:22020111 p(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23702978 act(p(HGNC:PRKCD), ma(kin)) increases p(HGNC:NLRC4, pmod(Ph, Ser))
pmid:22020111 p(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:14556719 p(HGNC:SOD1) decreases bp(GO:"response to oxidative stress")
pmid:24563850 p(HGNC:SOD1) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen)))
pmid:22020111 path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2))
pmid:22020111 path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation a(PUBCHEM:400769)
pmid:22020111 path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation act(p(HGNC:NFE2L2))
pmid:23454242 bp(GO:phosphorylation) regulates bp(GO:"cell division")
pmid:23454242 bp(GO:phosphorylation) regulates bp(GO:"cell growth")
pmid:23454242 bp(GO:phosphorylation) regulates bp(GO:"cell development")
pmid:23454242 bp(GO:phosphorylation) increases bp(GO:"negative regulation of apoptotic process")
pmid:23454242 bp(GO:phosphorylation) regulates bp(GO:"cell population proliferation")
pmid:23454242 bp(GO:phosphorylation) regulates bp(GO:"apoptotic process")
pmid:21882945 bp(GO:phosphorylation) regulates a(HBP:"Hsp27 oligomers")
pmid:25784053 bp(GO:"cell division") association p(FPLX:"CCT_complex")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"glycolytic process")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"lipid metabolic process")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"catecholamine biosynthetic process")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"cell cycle")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"DNA replication")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"transcription, DNA-templated")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:translation)
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"signal transduction")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"cell population proliferation")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"cell population proliferation")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"cytoskeleton organization")
pmid:23454242 p(FPLX:PPP2) increases bp(GO:"cytoskeleton organization")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"cell motility")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"apoptotic process")
pmid:23454242 p(FPLX:PPP2) regulates bp(GO:"apoptotic process")
pmid:23454242 p(FPLX:PPP2) association path(MESH:"Cell Transformation, Neoplastic")
pmid:23454242 p(FPLX:PPP2) association path(MESH:Neoplasms)
pmid:23454242 p(FPLX:PPP2) decreases path(MESH:Neoplasms)
pmid:23454242 act(p(FPLX:PPP2)) negativeCorrelation path(MESH:Neoplasms)
pmid:22299660 p(FPLX:PPP2) association path(MESH:Neoplasms)
pmid:23454242 p(FPLX:PPP2) decreases p(HGNC:VIM, pmod(Ph))
pmid:23454242 act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:22299660 act(p(FPLX:PPP2)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:23454242 act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(Me))
pmid:23454242 act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(Ph))
pmid:23454242 p(FPLX:PPP2) decreases p(FPLX:AKT, pmod(Ph, Thr, 308))
pmid:23454242 p(FPLX:PPP2) association bp(GO:"Wnt signaling pathway")
pmid:23454242 p(FPLX:PPP2) decreases p(HGNC:CTNNB1, pmod(Ph))
pmid:23454242 p(FPLX:PPP2) increases deg(p(HGNC:CTNNB1))
pmid:23454242 p(FPLX:PPP2) decreases p(HGNC:BAD, pmod(Ph))
pmid:23454242 p(FPLX:PPP2) decreases p(HGNC:BCL2, pmod(Ph))
pmid:12428809 p(FPLX:PPP2) decreases p(HGNC:MAPT, pmod(Ph))
pmid:22299660 p(FPLX:PPP2) association a(MESH:Cytosol)
pmid:22299660 p(FPLX:PPP2) association a(MESH:"Cell Nucleus")
pmid:22299660 p(FPLX:PPP2) association a(MESH:Mitochondria)
pmid:22299660 p(FPLX:PPP2) association a(MESH:Cytoskeleton)
pmid:22299660 p(FPLX:PPP2) association a(MESH:"Cell Membrane")
pmid:22299660 p(FPLX:PPP2) association path(MESH:"Frontotemporal Dementia")
pmid:22299660 act(p(FPLX:PPP2)) negativeCorrelation a(HBP:"paired helical filaments")
pmid:22299660 act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:22299660 act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 242))
pmid:22299660 act(p(FPLX:PPP2)) decreases act(p(HGNC:CDK5))
pmid:22299660 act(p(FPLX:PPP2)) decreases act(p(HGNC:TPK1))
pmid:22299660 act(p(FPLX:PPP2)) decreases act(p(HGNC:GSK3B))
pmid:22299660 act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(FPLX:PPP2) negativeCorrelation path(MESH:"Down Syndrome")
pmid:23943618 act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT))
pmid:27068745 act(p(FPLX:PPP2), ma(kin)) positiveCorrelation p(HGNC:UNC5B)
pmid:27068745 act(p(FPLX:PPP2), ma(kin)) increases act(p(HGNC:DAPK1))
pmid:23454242 bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2A)
pmid:23454242 bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2B)
pmid:23454242 bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2C)
pmid:29311797 bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1)
pmid:23454242 path(MESH:"Cell Transformation, Neoplastic") association p(FPLX:PPP2)
pmid:22299660 p(FPLX:PPP2C) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:23454242 p(HGNC:PPP2CA) association a(MESH:"Cell Membrane")
pmid:19277525 p(HGNC:PPP2CA) increases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat"))
pmid:19277525 p(HGNC:PPP2CA) increases complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 p(HGNC:PPP2CA) association act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 act(p(HGNC:PPP2CA)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 deg(p(HGNC:PPP2CA)) positiveCorrelation p(HGNC:IGBP1, frag("?"))
pmid:24653673 p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(Ph))
pmid:29191965 p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:29062069 act(p(HGNC:PPP2CA)) negativeCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:29626319 p(HGNC:PPP2CA) increases bp(GO:autophagy)
pmid:10464280 p(HGNC:PPP2CA) association complex(GO:microtubule)
pmid:10464280 p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA))
pmid:29228318 act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:19401603 act(p(HGNC:PPP2CA)) positiveCorrelation act(p(HGNC:PIN1))
pmid:19401603 act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:19401603 act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212))
pmid:23454242 p(HGNC:PPP2CB) association a(MESH:Cytosol)
pmid:23454242 p(HGNC:PPP2CB) association a(MESH:"Cell Nucleus")
pmid:24653673 p(HGNC:PPP2CB) association act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 deg(p(HGNC:PPP2CB)) positiveCorrelation p(HGNC:IGBP1, frag("?"))
pmid:24653673 p(HGNC:PPP2CB) decreases p(HGNC:MAPT, pmod(Ph))
pmid:23454242 a(MESH:"Cell Membrane") association p(HGNC:PPP2CA)
pmid:22299660 a(MESH:"Cell Membrane") association p(FPLX:PPP2)
pmid:21339331 a(MESH:"Cell Membrane") association p(HGNC:ANXA2)
pmid:21339331 a(MESH:"Cell Membrane") isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT))
pmid:23454242 a(MESH:Cytosol) association p(HGNC:PPP2CB)
pmid:23454242 a(MESH:Cytosol) association p(HGNC:PPP2R2A)
pmid:23454242 a(MESH:Cytosol) association p(HGNC:PPP2R2B)
pmid:23454242 a(MESH:Cytosol) association p(HGNC:PPP2R5A)
pmid:23454242 a(MESH:Cytosol) association p(HGNC:PPP2R5B)
pmid:23454242 a(MESH:Cytosol) association p(HGNC:PPP2R5E)
pmid:23454242 a(MESH:Cytosol) association p(HGNC:PPP2R5D)
pmid:22299660 a(MESH:Cytosol) association p(FPLX:PPP2)
pmid:23454242 a(MESH:"Cell Nucleus") association p(HGNC:PPP2CB)
pmid:23454242 a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5C)
pmid:23454242 a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5D)
pmid:22299660 a(MESH:"Cell Nucleus") association p(FPLX:PPP2)
pmid:19277525 p(HGNC:PPP2R1A) association p(INTERPRO:"HEAT repeat")
pmid:19277525 act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A))
pmid:19277525 act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:19277525 act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B))
pmid:19277525 act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A))
pmid:19277525 act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN3))
pmid:19277525 act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN))
pmid:19277525 act(p(HGNC:PPP2R1A)) increases act(p(HGNC:PPP2CA))
pmid:23454242 p(HGNC:PPP2R2A) association a(MESH:Cytosol)
pmid:23454242 p(HGNC:PPP2R2A) increases bp(GO:cytokinesis)
pmid:23454242 p(HGNC:PPP2R2A) association bp(GO:"cytoskeleton organization")
pmid:22299660 p(HGNC:PPP2R2A) association a(MESH:Brain)
pmid:22299660 p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:23454242 p(HGNC:PPP2R2B) association a(MESH:Cytosol)
pmid:23454242 p(HGNC:PPP2R2B) increases bp(GO:cytokinesis)
pmid:23454242 p(HGNC:PPP2R2B) association bp(GO:"cytoskeleton organization")
pmid:23454242 p(HGNC:PPP2R2C) association a(MESH:Cytoskeleton)
pmid:23454242 p(HGNC:PPP2R2C) increases bp(GO:cytokinesis)
pmid:23454242 p(HGNC:PPP2R2C) association bp(GO:"cytoskeleton organization")
pmid:19277525 p(HGNC:PPP2R3A) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A))
pmid:19277525 p(HGNC:PPP2R3A) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A))
pmid:19277525 p(HGNC:PPP2R3A) association p(INTERPRO:"EF-hand domain")
pmid:19277525 p(HGNC:PPP2R3B) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B))
pmid:19277525 p(HGNC:PPP2R3B) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B))
pmid:19277525 p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:19277525 p(HGNC:PTPA) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))
pmid:19277525 p(HGNC:PTPA) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:PTPA) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(HGNC:PTPA) decreases p(FPLX:PPP2, pmod(Ph, Tyr, 307))
pmid:23454242 p(HGNC:PPP2R5A) association a(MESH:Cytosol)
pmid:23454242 p(HGNC:PPP2R5B) association a(MESH:Cytosol)
pmid:21882945 p(HGNC:PPP2R5B) decreases p(HGNC:MAPT, pmod(Ph))
pmid:23454242 p(HGNC:PPP2R5C) association a(MESH:"Cell Nucleus")
pmid:23454242 p(HGNC:PPP2R5D) association a(MESH:Cytosol)
pmid:23454242 p(HGNC:PPP2R5D) association a(MESH:"Cell Nucleus")
pmid:24653673 p(HGNC:PPP2R5D) decreases p(HGNC:MAPT, pmod(Ph))
pmid:23454242 p(HGNC:PPP2R5E) association a(MESH:Cytosol)
pmid:28720530 p(HGNC:PPP2R5E) partOf complex(GO:"protein phosphatase type 2A complex")
pmid:23454242 a(MESH:Cytoskeleton) association p(HGNC:PPP2R2C)
pmid:22299660 a(MESH:Cytoskeleton) association p(FPLX:PPP2)
pmid:23454242 composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNC:PPP2R3A))
pmid:24027553 composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome))
pmid:23454242 complex(p(FPLX:PPP2), p(HGNC:SGO1)) decreases p(FPLX:Cohesin, pmod(Ph))
pmid:23454242 p(FPLX:Cohesin, pmod(Ph)) increases bp(GO:"spindle disassembly")
pmid:23454242 p(HGNC:SET) decreases act(p(FPLX:PPP2))
pmid:22299660 p(HGNC:SET) decreases act(p(FPLX:PPP2))
pmid:24653673 p(HGNC:SET) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:SET) increases complex(p(HGNC:PPP2CA), p(HGNC:SET))
pmid:24653673 p(HGNC:SET) increases complex(p(HGNC:PPP2CB), p(HGNC:SET))
pmid:24653673 p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23454242 a(CHEBI:"okadaic acid") increases path(MESH:Neoplasms)
pmid:23454242 a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2C))
pmid:19277525 a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:19277525 a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA))
pmid:19277525 a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPME1))
pmid:24653673 a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA))
pmid:24653673 a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB))
pmid:24653673 a(CHEBI:"okadaic acid") decreases bp(GO:cognition)
pmid:24653673 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 a(CHEBI:"okadaic acid") increases bp(HBP:amyloidogenesis)
pmid:24653673 a(CHEBI:"okadaic acid") decreases a(GO:synapse)
pmid:24653673 a(CHEBI:"okadaic acid") increases path(HBP:Neurodegeneration)
pmid:22299660 a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2))
pmid:22299660 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 189))
pmid:22299660 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:22299660 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:16464864 a(CHEBI:"okadaic acid") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:22299660 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:22299660 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:22299660 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:22299660 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22299660 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:22299660 a(CHEBI:"okadaic acid") decreases bp(GO:learning)
pmid:22299660 a(CHEBI:"okadaic acid") decreases bp(GO:memory)
pmid:16464864 a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Sumo, Lys, 340))
pmid:23454242 a(PUBCHEM:5311365) decreases act(p(FPLX:PPP2))
pmid:24653673 a(PUBCHEM:5311365) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA))
pmid:24653673 a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB))
pmid:23454242 a(CHEBI:microcystin) decreases act(p(FPLX:PPP2))
pmid:23454242 a(CHEBI:cantharidin) decreases act(p(FPLX:PPP2))
pmid:23454242 a(PUBCHEM:4162) decreases act(p(FPLX:PPP2))
pmid:23454242 a(PUBCHEM:6913994) decreases act(p(FPLX:PPP2))
pmid:24653673 a(PUBCHEM:6913994) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA))
pmid:24653673 a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB))
pmid:23454242 a(CHEBI:Tautomycin) decreases act(p(FPLX:PPP2))
pmid:23454242 a(PUBCHEM:71361092) increases path(MESH:Neoplasms)
pmid:23454242 a(PUBCHEM:71361092) decreases act(p(FPLX:PPP2))
pmid:23454242 p(HGNC:CIP2A) decreases act(p(FPLX:PPP2C))
pmid:23454242 a(CHEBI:bortezomib) decreases p(HGNC:CIP2A)
pmid:23454242 a(CHEBI:bortezomib) increases act(p(FPLX:PPP2C))
pmid:23454242 p(FPLX:PPP2, pmod(Me)) association act(p(FPLX:PPP2))
pmid:19277525 p(FPLX:PPP2, pmod(Me)) regulates bp(GO:"cell cycle")
pmid:24653673 p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(FPLX:PPP2, pmod(Me)) association bp(GO:"one-carbon metabolic process")
pmid:24653673 p(FPLX:PPP2, pmod(Me)) negativeCorrelation a(CHEBI:homocysteine)
pmid:24653673 p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:24653673 p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:APP, pmod(Ph))
pmid:24653673 p(FPLX:PPP2, pmod(Me)) regulates bp(HBP:"APP processing")
pmid:24653673 p(FPLX:PPP2, pmod(Me)) regulates bp(MESH:"Neuronal Outgrowth")
pmid:24653673 p(FPLX:PPP2, pmod(Me)) regulates p(HGNC:MAPT)
pmid:23454242 p(FPLX:PPP2, pmod(Ph)) association act(p(FPLX:PPP2))
pmid:23454242 p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(p(FPLX:PPP2))
pmid:24653673 p(FPLX:PPP2, pmod(Ph, Tyr, 307)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:23454242 p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me, Leu, 309))
pmid:19277525 p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:19277525 p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:23943618 p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:29281045 p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:19277525 act(p(HGNC:LCMT1)) negativeCorrelation act(p(HGNC:PPME1))
pmid:19277525 p(HGNC:LCMT1) causesNoChange act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309))
pmid:24653673 p(HGNC:LCMT1) regulates complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Membrane Microdomains"))
pmid:24653673 p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me))
pmid:23454242 p(FPLX:PPP2, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2))
pmid:23454242 p(FPLX:AKT, pmod(Ph, Thr, 308)) increases act(p(FPLX:AKT))
pmid:23454242 p(HGNC:CTNNB1, pmod(Ph)) increases bp(GO:"Wnt signaling pathway")
pmid:23454242 p(HGNC:BAD, pmod(Ph)) decreases bp(GO:"apoptotic process")
pmid:23454242 p(HGNC:BCL2, pmod(Ph)) decreases bp(GO:"apoptotic process")
pmid:19277525 complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell cycle")
pmid:19277525 complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell population proliferation")
pmid:19277525 complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell death")
pmid:19277525 complex(GO:"protein phosphatase type 2A complex") regulates act(a(GO:cytoskeleton))
pmid:19277525 complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell motility")
pmid:19277525 complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"signal transduction")
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CA)
pmid:19277525 complex(GO:"protein phosphatase type 2A complex") increases bp(GO:"protein dephosphorylation")
pmid:19277525 complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:19277525 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A))
pmid:24653673 complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GSK3B))
pmid:24653673 complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:CDK5))
pmid:24653673 complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Receptors, N-Methyl-D-Aspartate"))
pmid:24653673 complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GRM5))
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:PPME1)
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 complex(GO:"protein phosphatase type 2A complex") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CB)
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:ANP32A)
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET)
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET)
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET, frag("?"))
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(FPLX:PPP2, pmod(Ph, Tyr, 307))
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) decreases bp(GO:"neuron death")
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:GSK3B))
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:CDK5))
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:ERK))
pmid:24653673 act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:JNK))
pmid:10464280 act(complex(GO:"protein phosphatase type 2A complex")) association p(HBP:"microtubule-binding region")
pmid:10464280 act(complex(GO:"protein phosphatase type 2A complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT)))
pmid:28720530 complex(GO:"protein phosphatase type 2A complex") negativeCorrelation p(HBP:"APOE e4")
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") association p(INTERPRO:"WD40 repeat")
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases bp(GO:"protein dephosphorylation")
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:24653673 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(a(GO:"protein phosphatase type 2A complex"), a(GO:microtubule))
pmid:24653673 p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19277525 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) association p(FPLX:PPP2, pmod(Me))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates a(GO:microtubule)
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates bp(MESH:"Neuronal Outgrowth")
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") association p(INTERPRO:"HEAT repeat")
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") regulates complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:19277525 p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:24653673 p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus))
pmid:24653673 p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:centrosome))
pmid:19277525 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:19277525 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:19277525 p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3))
pmid:19277525 p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3))
pmid:19277525 p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN))
pmid:19277525 p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(HGNC:PPP2CA))
pmid:24653673 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:23943618 p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me)) decreases complex(p(HGNC:IGBP1), p(HGNC:PPP2CA))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:29228318 p(HGNC:PPP2CA, pmod(Me)) increases act(p(HGNC:PPP2CA))
pmid:24653673 complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:19277525 p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:19277525 p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:19277525 p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:24653673 act(p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:19277525 act(p(HGNC:PPME1)) negativeCorrelation act(p(HGNC:LCMT1))
pmid:19277525 p(HGNC:PPME1) increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))
pmid:19277525 p(HGNC:PPME1) directlyIncreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))
pmid:19277525 p(HGNC:PPME1) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPME1) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CA))
pmid:24653673 p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CB))
pmid:22299660 p(HGNC:PPME1) decreases p(FPLX:PPP2C, pmod(Me))
pmid:19277525 p(INTERPRO:"HEAT repeat") association p(HGNC:PPP2R1A)
pmid:19277525 p(INTERPRO:"HEAT repeat") association p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")
pmid:19277525 p(UNIPROT:P03081) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(UNIPROT:P03081))
pmid:19277525 p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat"))
pmid:19277525 p(INTERPRO:"HEAT repeat", var("p.Val545Ala")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat"))
pmid:19277525 a(CHEBI:"microcystin-LR") decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:19277525 a(CHEBI:"microcystin-LR") decreases act(p(HGNC:PPME1))
pmid:29228318 a(CHEBI:"microcystin-LR") decreases p(HGNC:PPP2CA, pmod(Me))
pmid:19277525 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases bp(GO:"cell cycle")
pmid:19277525 p(INTERPRO:"WD40 repeat") association p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")
pmid:19277525 p(INTERPRO:"EF-hand domain") association p(HGNC:PPP2R3A)
pmid:19277525 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:19277525 complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56"))
pmid:19277525 complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:19277525 complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(GO:"protein phosphatase type 2A complex")
pmid:19277525 complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1))
pmid:19277525 complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1))
pmid:19277525 complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1))
pmid:19277525 complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA))
pmid:19277525 complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA))
pmid:19277525 complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:19277525 complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:19277525 composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 a(CHEBI:"S-adenosyl-L-methionine") increases act(p(HGNC:LCMT1))
pmid:24653673 a(CHEBI:"S-adenosyl-L-homocysteine") decreases act(p(HGNC:LCMT1))
pmid:24653673 complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) association p(FPLX:PPP2, pmod(Me))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:Tauopathies)
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates a(GO:microtubule)
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates bp(MESH:"Neuronal Outgrowth")
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CA, pmod(Ub)) increases deg(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2CA, pmod(HBP:nitration, Tyr)) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2R5A, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2R5D, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A))
pmid:24653673 p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A))
pmid:24653673 p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 a(CHEBI:"metal cation") increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 a(CHEBI:ceramide) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:29758300 a(CHEBI:ceramide) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 a(CHEBI:polyamine) increases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:21882945 a(CHEBI:polyamine) decreases act(p(INTERPRO:"Heat shock protein 70 family"))
pmid:24653673 complex(p(HGNC:LCMT1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 complex(p(HGNC:LCMT1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 complex(p(HGNC:IGBP1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 complex(p(HGNC:PPP2CA), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 complex(p(HGNC:PPP2CB), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 g(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 g(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 r(HGNC:PPP2R2C) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 r(HGNC:PPP2R5E) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
pmid:29758300 path(MESH:Tauopathies) association p(HGNC:MAPT)
pmid:29758300 path(MESH:Tauopathies) association path(MESH:Dementia)
pmid:29758300 path(MESH:Tauopathies) positiveCorrelation p(HGNC:BIN1)
pmid:30145931 path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:29024336 path(MESH:Tauopathies) increases path(MESH:"Proteostasis Deficiencies")
pmid:24027553 path(MESH:Tauopathies) positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:27574109 path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers")
pmid:29686391 path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers")
pmid:27574109 path(MESH:Tauopathies) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:21734277 path(MESH:Tauopathies) association p(HBP:"AT8 tau", pmod(Ph))
pmid:30108137 path(MESH:Tauopathies) increases p(MGI:Tfeb)
pmid:30108137 path(MESH:Tauopathies) increases p(MGI:Tfeb)
pmid:30108137 path(MESH:Tauopathies) increases p(MGI:Lamp1)
pmid:30108137 path(MESH:Tauopathies) increases p(MGI:Ctsd)
pmid:21882945 path(MESH:Tauopathies) positiveCorrelation bp(GO:"neuron death")
pmid:28420982 path(MESH:Tauopathies) association bp(GO:"neuron death")
pmid:21882945 path(MESH:Tauopathies) negativeCorrelation bp(GO:cognition)
pmid:30126037 path(MESH:Tauopathies) association bp(GO:"cellular senescence")
pmid:30126037 path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive")
pmid:22419736 path(MESH:Tauopathies) association a(CHEBI:"amyloid-beta polypeptide 42")
pmid:29191965 path(MESH:Tauopathies) association p(HGNC:WNT2)
pmid:29191965 path(MESH:Tauopathies) association p(HGNC:TTBK2)
pmid:29191965 path(MESH:Tauopathies) association p(HGNC:GSK3B)
pmid:29191965 path(MESH:Tauopathies) association p(HGNC:TAOK1)
pmid:29191965 path(MESH:Tauopathies) association p(HGNC:CTSE)
pmid:29191965 path(MESH:Tauopathies) association p(HGNC:CHRNA7)
pmid:25374103 path(MESH:Tauopathies) positiveCorrelation p(FPLX:Caspase)
pmid:28420982 path(MESH:Tauopathies) association a(HBP:"Tau annular protofibrils")
pmid:26631930 path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
pmid:26631930 path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:26631930 path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
pmid:26631930 path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?"))
pmid:24653673 p(FPLX:PPP2, pmod(Me, Tyr, 307)) association a(GO:"neurofibrillary tangle")
pmid:24653673 p(FPLX:PPP2, pmod(Me, Tyr, 307)) association p(HGNC:MAPT, pmod(Ph))
pmid:24653673 p(HGNC:SET, frag("?")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24653673 p(HGNC:SET, frag("?")) increases path(MESH:"Alzheimer Disease")
pmid:24653673 p(HGNC:SET, frag("?")) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex"))
pmid:24653673 p(FPLX:CAPN) increases p(HGNC:IGBP1, frag("?"))
pmid:22908190 p(FPLX:CAPN) increases deg(p(HGNC:MAPT))
pmid:29626319 p(FPLX:CAPN) increases deg(p(HGNC:MAPT))
pmid:29626319 p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?"))
pmid:24653673 p(HGNC:IGBP1, frag("?")) regulates complex(GO:"protein phosphatase type 2A complex")
pmid:24653673 p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CA))
pmid:24653673 p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CB))
pmid:24653673 p(HGNC:PPP2CA, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 p(HGNC:PPP2CB, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B))
pmid:24653673 a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5))
pmid:24653673 a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK))
pmid:24653673 a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B))
pmid:24653673 a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:CDK5))
pmid:24653673 a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(FPLX:ERK))
pmid:24653673 bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:GSK3B))
pmid:24653673 bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:CDK5))
pmid:24653673 bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(FPLX:ERK))
pmid:25374103 complex(a(GO:microtubule), p(HGNC:MAPT)) decreases p(HGNC:MAPT, pmod(HBP:misfolded))
pmid:26631930 complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"microtubule bundle formation")
pmid:26631930 complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"actin cytoskeleton reorganization")
pmid:26631930 complex(a(GO:microtubule), p(HGNC:MAPT)) negativeCorrelation a(HBP:"Tau aggregates")
pmid:26631930 complex(a(GO:microtubule), p(HGNC:MAPT)) decreases a(HBP:"Tau aggregates")
pmid:24653673 bp(GO:"one-carbon metabolic process") association p(FPLX:PPP2, pmod(Me))
pmid:24653673 bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 bp(GO:"one-carbon metabolic process") decreases bp(HBP:amyloidogenesis)
pmid:24653673 bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(Ph, Thr, 668))
pmid:24653673 bp(GO:"one-carbon metabolic process") decreases bp(GO:cognition)
pmid:24653673 bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:"amyloid-beta"))
pmid:24653673 a(CHEBI:folates) decreases p(FPLX:PPP2, pmod(Me))
pmid:24653673 a(CHEBI:folates) increases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 a(CHEBI:folates) increases p(HGNC:APP, pmod(Ph))
pmid:24653673 path(MESH:"Vitamin B Deficiency") decreases p(FPLX:PPP2, pmod(Me))
pmid:24653673 path(MESH:"Vitamin B Deficiency") increases p(HGNC:MAPT, pmod(Ph))
pmid:24653673 path(MESH:"Vitamin B Deficiency") increases p(HGNC:APP, pmod(Ph))
pmid:24653673 a(CHEBI:homocysteine) negativeCorrelation p(FPLX:PPP2, pmod(Me))
pmid:24653673 a(CHEBI:homocysteine) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:24653673 a(CHEBI:homocysteine) positiveCorrelation p(HGNC:APP, pmod(Ph))
pmid:28632203 a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:26323690 bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(Ph))
pmid:12428809 p(HGNC:MAPK9) increases p(HGNC:MAPT, pmod(Ph))
pmid:12428809 p(HGNC:MARK1) increases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:21311567 act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22952452 act(p(HGNC:MARK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:21311567 act(p(HGNC:MARK1)) decreases bp(GO:"microtubule polymerization")
pmid:22952452 p(HGNC:MARK1) negativeCorrelation p(HGNC:TRAK1)
pmid:22952452 p(HGNC:MARK1) negativeCorrelation p(HGNC:RHOT1)
pmid:12428809 p(HGNC:CAMK2B) increases p(HGNC:MAPT, pmod(Ph))
pmid:27796283 p(HGNC:CAMK2B) increases p(HBP:"Kalirin 7", pmod(Ph, Thr, 95))
pmid:12428809 p(FPLX:CK2) increases p(HGNC:MAPT, pmod(Ph))
pmid:12428809 p(FPLX:PPP1) decreases p(HGNC:MAPT, pmod(Ph))
pmid:12428809 p(FPLX:PPP3) decreases p(HGNC:MAPT, pmod(Ph))
pmid:12428809 p(HBP:"4R tau") increases path(MESH:"Wallerian Degeneration")
pmid:12428809 p(HBP:"4R tau") increases path(MESH:"Muscular Atrophy")
pmid:12428809 p(HBP:"4R tau") increases path(HP:Neurodegeneration)
pmid:12428809 p(HBP:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:12428809 p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration")
pmid:26631930 p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration")
pmid:26751493 p(HBP:"4R tau") positiveCorrelation path(HBP:"Argyrophilic Grain Disease")
pmid:26751493 p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:26631930 p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:26631930 p(HBP:"4R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"4R tau"))
pmid:23407988 p(HBP:"4R tau") isA p(HGNC:MAPT)
pmid:23407988 p(HBP:"4R tau") partOf a(HBP:pretangles)
pmid:23407988 p(HBP:"4R tau") partOf complex(GO:"neurofibrillary tangle")
pmid:23407988 p(HBP:"4R tau") positiveCorrelation a(HBP:"CA4 field of hippocampus")
pmid:23407988 p(HBP:"4R tau") positiveCorrelation a(HBP:"CA3 field of hippocampus")
pmid:23407988 p(HBP:"4R tau") positiveCorrelation a(HBP:"CA2 field of hippocampus")
pmid:23407988 p(HBP:"4R tau") positiveCorrelation a(HBP:"CA1 field of hippocampus")
pmid:23407988 p(HBP:"4R tau") positiveCorrelation a(HBP:"Brodmann (1909) area 36")
pmid:23407988 p(HBP:"4R tau") partOf complex(GO:"neuronal cell body")
pmid:23407988 p(HBP:"4R tau") partOf complex(GO:dendrite)
pmid:23407988 p(HBP:"4R tau") partOf a(MESH:Neuropil)
pmid:28775333 p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a)
pmid:21427723 p(HBP:"4R tau") partOf path(HBP:"4R tauopathy")
pmid:27574109 p(HBP:"4R tau") positiveCorrelation p(HBP:"phosphatase-activating domain")
pmid:12428809 a(MESH:"Intermediate Filaments") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:12428809 a(MESH:"Intermediate Filaments") negativeCorrelation a(MESH:Axons)
pmid:12428809 a(MESH:Axons) negativeCorrelation a(MESH:"Intermediate Filaments")
pmid:27671637 a(MESH:Axons) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:12428809 p(HBP:"3R tau") increases a(HBP:"straight filaments")
pmid:26751493 p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases")
pmid:26631930 p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases")
pmid:26631930 p(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HBP:"3R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"3R tau"))
pmid:23407988 p(HBP:"3R tau") isA p(HGNC:MAPT)
pmid:23407988 p(HBP:"3R tau") partOf complex(GO:"neurofibrillary tangle")
pmid:23407988 p(HBP:"3R tau") partOf a(HBP:"ghost tangles")
pmid:23407988 p(HBP:"3R tau") partOf a(HBP:"Brodmann (1909) area 36")
pmid:23407988 p(HBP:"3R tau") partOf a(HBP:"CA1 field of hippocampus")
pmid:23407988 p(HBP:"3R tau") partOf a(HBP:"CA2 field of hippocampus")
pmid:23407988 p(HBP:"3R tau") partOf a(HBP:"CA3 field of hippocampus")
pmid:23407988 p(HBP:"3R tau") partOf a(HBP:"CA4 field of hippocampus")
pmid:23407988 p(HBP:"3R tau") partOf complex(GO:dendrite)
pmid:23407988 p(HBP:"3R tau") partOf a(MESH:Neuropil)
pmid:23407988 p(HBP:"3R tau") partOf complex(GO:"neuronal cell body")
pmid:26655600 p(HBP:"3R tau") negativeCorrelation bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"3R tau") positiveCorrelation complex(GO:"Pick body")
pmid:28775333 p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a)
pmid:28775333 p(HBP:"3R tau") negativeCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate")
pmid:12428809 a(HBP:"straight filaments") association path(MESH:"Alzheimer Disease")
pmid:12428809 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HBP:"4R tau")
pmid:22299660 path(MESH:"Frontotemporal Dementia") association p(FPLX:PPP2)
pmid:29758300 path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT)
pmid:28420982 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT)
pmid:29758300 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding))
pmid:30116051 path(MESH:"Frontotemporal Dementia") association p(HGNC:SQSTM1)
pmid:30116051 path(MESH:"Frontotemporal Dementia") association p(HGNC:C9orf72)
pmid:30116051 path(MESH:"Frontotemporal Dementia") increases act(p(HGNC:ABL1))
pmid:29024336 path(MESH:"Frontotemporal Dementia") increases path(MESH:"Proteostasis Deficiencies")
pmid:24027553 path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("p.P301L"))
pmid:24027553 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:NPEPPS)
pmid:30108137 path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB)
pmid:30108137 path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1)
pmid:30108137 path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB)
pmid:30108137 path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD)
pmid:28420982 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:28420982 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:26751493 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:26751493 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met"))
pmid:26751493 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val"))
pmid:26751493 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp"))
pmid:26751493 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val"))
pmid:26631930 path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:8391280 path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424)
pmid:24027553 act(a(MESH:Microtubules)) association act(p(HGNC:HTRA1))
pmid:29238289 act(a(MESH:Microtubules)) association p(HGNC:MAPT)
pmid:25374103 bp(GO:"anterograde axonal transport") negativeCorrelation p(HGNC:MAPT)
pmid:25374103 bp(GO:"anterograde axonal transport") decreases a(GO:microtubule)
pmid:25374103 bp(GO:"anterograde axonal transport") positiveCorrelation composite(p(HGNC:MAPT), p(HGNC:MARK2))
pmid:12428809 p(HGNC:APPL) increases bp(GO:"anterograde axonal transport")
pmid:20133804 bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule)
pmid:19459590 bp(GO:"microtubule polymerization") positiveCorrelation act(p(HGNC:MAPT))
pmid:22299660 a(MESH:Mitochondria) association p(FPLX:PPP2)
pmid:30126037 act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration")
pmid:22299660 a(HBP:"paired helical filaments") negativeCorrelation act(p(FPLX:PPP2))
pmid:14556719 a(HBP:"paired helical filaments") decreases act(complex(GO:"proteasome complex"))
pmid:22908190 a(HBP:"paired helical filaments") negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:22908190 a(HBP:"paired helical filaments") association a(GO:"neurofibrillary tangle")
pmid:22908190 a(HBP:"paired helical filaments") association a(HBP:"dystrophic neurite")
pmid:22908190 a(HBP:"paired helical filaments") association p(HGNC:MAPT)
pmid:22908190 a(HBP:"paired helical filaments") association p(HGNC:MAPT)
pmid:22908190 a(HBP:"paired helical filaments") association a(MESH:Ubiquitin)
pmid:22908190 a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254))
pmid:22908190 a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257))
pmid:22908190 a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311))
pmid:22908190 a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317))
pmid:22908190 a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48))
pmid:22908190 a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48))
pmid:22908190 a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6))
pmid:22908190 a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11))
pmid:26631930 a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:26631930 a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 394))
pmid:16566606 a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
pmid:16566606 a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:16566606 a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197))
pmid:16566606 a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
pmid:7667312 a(HBP:"paired helical filaments") positiveCorrelation a(HBP:"Thioflavin S")
pmid:7667312 a(HBP:"paired helical filaments") partOf complex(GO:"neurofibrillary tangle")
pmid:8391280 a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 254))
pmid:8391280 a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 257))
pmid:8391280 a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 311))
pmid:22299660 p(HGNC:MAPT, pmod(Ph, Ser, 189)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26458742 p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 199)) isA p(RGD:Mapt, pmod(Ph))
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 199)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT))
pmid:20071522 p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:FKBP5)
pmid:21367866 p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:CDC37)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(FPLX:PKA)
pmid:25331948 p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8")
pmid:19459590 p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8")
pmid:22299660 p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29191965 p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases p(HGNC:MAPT, frag("?"))
pmid:22817713 p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau oligomers")
pmid:26671985 p(HGNC:MAPT, pmod(Ph, Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy")
pmid:26671985 p(HGNC:MAPT, pmod(Ph, Ser, 422)) increases path(MESH:"Cognitive Dysfunction")
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(FPLX:PKA)
pmid:18239272 p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(GO:"neurofibrillary tangle")
pmid:18239272 p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(MESH:"Neuropil Threads")
pmid:18239272 p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf path(MESH:"Plaque, Amyloid")
pmid:18239272 p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:pretangles)
pmid:11943212 p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau epitope, AP422")
pmid:26118667 p(HGNC:MAPT, pmod(Ph, Ser, 422)) negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:23294633 p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:27373205 p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"phosphatase-activating domain")
pmid:27373205 p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau dimers")
pmid:27373205 p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases bp(GO:"anterograde axonal transport")
pmid:22299660 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:MAPT, pmod(Ph, Ser, 262)) increases bp(GO:autophagy)
pmid:30145931 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"amyloid-beta oligomers")
pmid:30145931 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(CHEBI:wortmannin)
pmid:30145931 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(CHEBI:epoxomicin)
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly")
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly")
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_284")))
pmid:25374103 p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1))
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:17493042 p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
pmid:17493042 p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:21367866 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:CDC37)
pmid:11943212 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MARK4, pmod(Ph))
pmid:11943212 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"granulovacuolar degeneration")
pmid:22692785 p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(GO:"neurofibrillary tangle")
pmid:22156579 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin))
pmid:22156579 p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(HBP:"Tau epitope, 12E8")
pmid:23948915 p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation bp(GO:"apoptotic process")
pmid:26118667 p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:22833681 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation"))
pmid:22952452 p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:Neurodegeneration)
pmid:22299660 p(FPLX:PPP2C, pmod(Me)) increases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C))
pmid:22299660 p(HGNC:ICMT) increases p(FPLX:PPP2C, pmod(Me))
pmid:22299660 p(HGNC:ICMT) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) increases act(p(FPLX:PPP2))
pmid:22299660 p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(FPLX:PPP2C, pmod(Me, Leu, 309)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22299660 p(FPLX:PPP2C, pmod(Me, Leu, 309)) decreases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C))
pmid:22299660 p(FPLX:PPP2C, pmod(Ph)) association a(MESH:"Neurofibrillary Tangles")
pmid:28083634 p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ub))
pmid:28083634 p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1))
pmid:28083634 p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1))
pmid:28083634 p(HGNC:OTUB1) increases a(HBP:"Tau aggregates")
pmid:28083634 p(HGNC:OTUB1) increases a(HBP:"Tau aggregates")
pmid:28083634 p(HGNC:OTUB1) increases a(HBP:"Tau aggregates")
pmid:28083634 p(HGNC:OTUB1) increases a(HBP:"Tau aggregates")
pmid:28083634 p(HGNC:OTUB1) negativeCorrelation a(HBP:"Tau aggregates")
pmid:28083634 p(HGNC:OTUB1) regulates p(HGNC:MAPT)
pmid:28083634 p(HGNC:OTUB1) increases p(HGNC:MAPT)
pmid:28083634 p(HGNC:OTUB1) decreases deg(p(HGNC:MAPT))
pmid:28083634 p(HGNC:OTUB1) regulates deg(p(HGNC:MAPT))
pmid:28083634 p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(HGNC:OTUB1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(HGNC:OTUB1) increases a(HBP:"Tau oligomers")
pmid:28083634 p(HGNC:OTUB1) increases a(HBP:"Tau oligomers")
pmid:28083634 p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(UbK48))
pmid:28083634 p(HGNC:OTUB1) causesNoChange p(HGNC:MAPT, pmod(UbK63))
pmid:22908190 p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24027553 p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Neurofibrillary Tangles")
pmid:14612456 p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:UBE2D2)
pmid:14612456 p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:8391280 p(HGNC:MAPT, pmod(Ub)) increases deg(p(HGNC:MAPT))
pmid:25378699 p(HGNC:MAPT, pmod(Ub)) positiveCorrelation deg(p(HGNC:MAPT))
pmid:24905733 p(HGNC:MAPT, pmod(Ub)) negativeCorrelation act(p(HGNC:MAPT))
pmid:28083634 complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases p(HGNC:MAPT, pmod(Ph))
pmid:28083634 complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases a(HBP:"Tau aggregates")
pmid:28083634 p(HGNC:USP5) decreases p(HGNC:MAPT, pmod(Ub))
pmid:28083634 p(HGNC:USP5) increases complex(p(HGNC:MAPT), p(HGNC:USP5))
pmid:28083634 p(HGNC:USP5) causesNoChange a(HBP:"Tau aggregates")
pmid:28083634 p(HGNC:USP9X) decreases p(HGNC:MAPT, pmod(Ub))
pmid:28083634 p(HGNC:USP9X) increases complex(p(HGNC:MAPT), p(HGNC:USP9X))
pmid:28083634 p(HGNC:USP9X) causesNoChange a(HBP:"Tau aggregates")
pmid:28083634 p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(UbK48))
pmid:28083634 p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange deg(p(HGNC:MAPT))
pmid:28083634 p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(HGNC:OTUB1, frag("?")) decreases p(HGNC:MAPT, pmod(UbK48))
pmid:28083634 p(HGNC:OTUB1, frag("?")) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(MGI:Otub1) increases p(MGI:Mapt)
pmid:28083634 p(MGI:Otub1) increases a(HBP:"Tau oligomers")
pmid:28083634 p(MGI:Otub1) increases a(HBP:"Tau oligomers")
pmid:28083634 p(MGI:Otub1) increases a(HBP:"Tau oligomers")
pmid:29024336 p(MGI:Mapt) decreases bp(GO:"late endosomal microautophagy")
pmid:29202785 p(MGI:Mapt) increases bp(GO:"neuron migration")
pmid:29202785 p(MGI:Mapt) increases bp(GO:"neuron differentiation")
pmid:29202785 p(MGI:Mapt) increases bp(GO:"neuron maturation")
pmid:30126037 p(MGI:Mapt) increases a(GO:"neurofibrillary tangle")
pmid:30126037 p(MGI:Mapt) increases bp(HP:Neurodegeneration)
pmid:30126037 p(MGI:Mapt) increases p(MGI:Cdkn2a)
pmid:30126037 p(MGI:Mapt) increases bp(GO:"cellular senescence")
pmid:30126037 p(MGI:Mapt) increases path(HP:"Brain atrophy")
pmid:28408124 tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"Tau aggregates")
pmid:18096814 p(MGI:Mapt) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid")
pmid:26400044 p(MGI:Mapt) increases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph)))
pmid:25995053 p(MGI:Mapt) association p(MGI:Dapk1)
pmid:25995053 p(MGI:Mapt) partOf complex(p(MGI:Dapk1), p(MGI:Mapt))
pmid:29221819 p(MGI:Mapt) negativeCorrelation p(MGI:Dyrk1a)
pmid:28877763 p(MGI:Mapt) positiveCorrelation p(MGI:Syk)
pmid:28083634 p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:28083634 p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange a(HBP:"Tau oligomers")
pmid:28083634 p(MGI:Otub1, frag("?")) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:25437566 act(p(FPLX:HSP90)) association a(CHEBI:ATP)
pmid:25437566 p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25437566 p(FPLX:HSP90) increases bp(GO:"protein folding")
pmid:23746257 act(p(FPLX:HSP90)) increases bp(GO:"protein folding")
pmid:25784053 p(FPLX:HSP90) regulates bp(GO:"protein folding")
pmid:29311797 act(p(FPLX:HSP90)) increases bp(GO:"protein folding")
pmid:27491084 p(FPLX:HSP90) association bp(HBP:Proteostasis)
pmid:29311797 p(FPLX:HSP90) association bp(HBP:Proteostasis)
pmid:23746257 act(p(FPLX:HSP90)) association bp(GO:"'de novo' protein folding")
pmid:23746257 act(p(FPLX:HSP90)) association bp(GO:"protein refolding")
pmid:23746257 p(FPLX:HSP90) association bp(GO:"cell cycle")
pmid:23746257 p(FPLX:HSP90) association bp(GO:"steroid hormone mediated signaling pathway")
pmid:23746257 p(FPLX:HSP90) association bp(GO:"calcium-mediated signaling")
pmid:23746257 p(FPLX:HSP90) association bp(GO:"protein transport")
pmid:23746257 p(FPLX:HSP90) association bp(GO:"protein secretion")
pmid:23746257 p(FPLX:HSP90) association bp(GO:"immune response")
pmid:23746257 p(FPLX:HSP90) association bp(MESH:"Heat-Shock Response")
pmid:25784053 p(FPLX:HSP90) isA a(MESH:"Molecular Chaperones")
pmid:25784053 p(FPLX:HSP90) regulates bp(MESH:Proteolysis)
pmid:29311797 act(p(FPLX:HSP90)) increases bp(MESH:Proteolysis)
pmid:25784053 act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1))
pmid:24563850 p(FPLX:HSP90) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:29311797 act(p(FPLX:HSP90)) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:29311797 p(FPLX:HSP90) regulates path(MESH:"Protein Aggregation, Pathological")
pmid:21882945 act(p(FPLX:HSP90)) association a(CHEBI:celastrol)
pmid:21882945 p(FPLX:HSP90) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins")
pmid:21882945 p(FPLX:HSP90) increases bp(GO:"proteasomal protein catabolic process")
pmid:21882945 p(FPLX:HSP90) increases bp(GO:autophagy)
pmid:21882945 p(FPLX:HSP90) increases act(p(HGNC:STUB1))
pmid:21882945 p(FPLX:HSP90) increases bp(GO:"protein catabolic process")
pmid:21882945 p(FPLX:HSP90) increases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:21882945 p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(Ph))
pmid:21882945 p(FPLX:HSP90) regulates p(HGNC:MAPT, pmod(Ph))
pmid:19363271 p(FPLX:HSP90) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:21882945 p(FPLX:HSP90) regulates act(p(HGNC:GSK3B))
pmid:21882945 p(FPLX:HSP90) regulates p(HGNC:MAPT, var("?"))
pmid:29311797 p(FPLX:HSP90) increases p(HGNC:MAPT, var("?"))
pmid:25374103 p(FPLX:HSP90) regulates deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:29311797 p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:25374103 p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(HBP:misfolded)))
pmid:29311797 act(p(FPLX:HSP90)) increases bp(GO:"protein modification process")
pmid:29311797 p(FPLX:HSP90) regulates a(HBP:"Tau aggregates")
pmid:29311797 p(FPLX:HSP90) increases act(p(FPLX:Proteasome))
pmid:29311797 p(FPLX:HSP90) association bp(GO:"chaperone-mediated autophagy")
pmid:29311797 act(p(FPLX:HSP90), ma(GO:"ATPase activity")) increases path(MESH:Tauopathies)
pmid:19363271 p(FPLX:HSP90) association p(HBP:"VQIVYK motif")
pmid:19363271 p(FPLX:HSP90) increases complex(p(FPLX:HSP90), p(HGNC:MAPT))
pmid:19363271 p(FPLX:HSP90) positiveCorrelation bp(GO:"neurofibrillary tangle assembly")
pmid:20133804 p(FPLX:HSP90) association p(HGNC:FKBP4, frag("270_386"))
pmid:21367866 act(p(FPLX:HSP90)) positiveCorrelation p(HGNC:CDC37)
pmid:21367866 act(p(FPLX:HSP90)) negativeCorrelation deg(p(HGNC:MAPT))
pmid:25437566 act(p(FPLX:HSPA)) association a(CHEBI:ATP)
pmid:27491084 p(FPLX:HSPA) association bp(HBP:Proteostasis)
pmid:27491084 p(FPLX:HSPA) decreases p(HBP:"huntingtin aggregates")
pmid:27491084 p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:24563850 p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:27491084 p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding")
pmid:23746257 act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding")
pmid:23746257 act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding")
pmid:24563850 p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding")
pmid:27491084 p(FPLX:HSPA) decreases bp(HBP:misfolding)
pmid:24563850 p(FPLX:HSPA) decreases bp(HBP:misfolding)
pmid:27491084 p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates")
pmid:27491084 p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates")
pmid:27491084 p(FPLX:HSPA) decreases path(HBP:proteotoxicity)
pmid:27491084 p(FPLX:HSPA) decreases path(HBP:proteotoxicity)
pmid:27491084 p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates")
pmid:23746257 p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates")
pmid:14556719 p(FPLX:HSPA) increases complex(p(HGNC:ATXN3, frag("?")), p(HGNC:PRKN))
pmid:14556719 p(FPLX:HSPA) increases a(HBP:"protein aggregates")
pmid:14556719 p(FPLX:HSPA) increases bp(GO:"cell death")
pmid:23746257 act(p(FPLX:HSPA)) association bp(GO:"protein refolding")
pmid:23746257 act(p(FPLX:HSPA)) association bp(GO:"protein refolding")
pmid:23746257 act(p(FPLX:HSPA)) association bp(GO:"intracellular protein transmembrane transport")
pmid:23746257 act(p(FPLX:HSPA)) association bp(GO:"protein catabolic process")
pmid:23746257 p(FPLX:HSPA) decreases a(HBP:"huntingtin aggregates")
pmid:25784053 p(FPLX:HSPA) isA a(MESH:"Molecular Chaperones")
pmid:25784053 p(FPLX:HSPA) regulates bp(GO:"protein folding")
pmid:24563850 p(FPLX:HSPA) increases bp(GO:"protein folding")
pmid:25784053 p(FPLX:HSPA) regulates bp(MESH:Proteolysis)
pmid:25784053 p(FPLX:HSPA) positiveCorrelation path(MESH:"Huntington Disease")
pmid:29626319 p(FPLX:HSPA) increases deg(a(CHEBI:"amyloid-beta"))
pmid:25437566 act(p(HGNC:HSPD1)) association a(CHEBI:ATP)
pmid:27491084 p(HGNC:HSPD1) association bp(HBP:Proteostasis)
pmid:25784053 p(HGNC:HSPD1) increases bp(HBP:Proteostasis)
pmid:23746257 p(HGNC:HSPD1) decreases a(MESH:"Protein Aggregates")
pmid:25784053 p(HGNC:HSPD1) isA a(MESH:"Molecular Chaperones")
pmid:25784053 p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism")
pmid:27491084 p(HGNC:TPR) association bp(HBP:Proteostasis)
pmid:27491084 p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") association bp(HBP:Proteostasis)
pmid:27491084 p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") increases act(p(FPLX:HSPA), ma(GO:"ATPase activity"))
pmid:23746257 p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") regulates act(p(FPLX:HSPA))
pmid:23746257 p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"huntingtin aggregates")
pmid:23746257 p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"alpha-synuclein aggregates")
pmid:25784053 p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") isA a(MESH:"Molecular Chaperones")
pmid:27491084 p(FPLX:HSPB) association bp(HBP:Proteostasis)
pmid:27491084 p(FPLX:HSPB) association bp(HBP:misfolding)
pmid:23746257 act(p(FPLX:HSPB)) decreases a(MESH:"Protein Aggregates")
pmid:25784053 p(FPLX:HSPB) isA a(MESH:"Molecular Chaperones")
pmid:25437566 p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25437566 p(HGNC:HSPA8) increases bp(GO:"protein folding")
pmid:25437566 p(HGNC:HSPA8) increases a(HBP:"huntingtin aggregates")
pmid:29758300 p(HGNC:HSPA8) increases deg(p(HGNC:MAPT))
pmid:21882945 act(p(HGNC:HSPA8)) increases deg(p(HGNC:MAPT))
pmid:18930136 p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8))
pmid:18930136 p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8))
pmid:24706768 p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis")
pmid:24706768 p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis")
pmid:24706768 p(HGNC:HSPA8) increases bp(GO:"clathrin coat disassembly")
pmid:21882945 p(HGNC:HSPA8) regulates complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:18500754 p(HGNC:HSPA8) association p(HBP:"microtubule-binding region")
pmid:18500754 act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule))
pmid:25437566 p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25437566 p(FPLX:"CCT_complex") increases a(HBP:"huntingtin aggregates")
pmid:23746257 p(FPLX:"CCT_complex") decreases a(HBP:"huntingtin aggregates")
pmid:25784053 p(FPLX:"CCT_complex") association a(MESH:"Cellular Structures")
pmid:25784053 p(FPLX:"CCT_complex") association bp(GO:"cell division")
pmid:25784053 p(FPLX:"CCT_complex") association bp(GO:"intracellular transport")
pmid:25784053 p(FPLX:"CCT_complex") decreases act(p(HGNC:HSF1))
pmid:25437566 p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25437566 p(HGNC:DNAJA1) increases bp(GO:"protein folding")
pmid:25437566 p(HGNC:DNAJA1) increases a(HBP:"huntingtin aggregates")
pmid:25437566 p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:23746257 p(HGNC:STIP1) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity"))
pmid:25036637 p(HGNC:STIP1) increases complex(p(HGNC:STIP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:29311797 p(HGNC:STIP1) decreases p(HGNC:MAPT)
pmid:29311797 p(HGNC:STIP1) association bp(GO:"chaperone-mediated autophagy")
pmid:25784053 bp(GO:"protein folding") association bp(HBP:Proteostasis)
pmid:29311797 bp(GO:"protein folding") association a(MESH:"Molecular Chaperones")
pmid:25437566 p(HGNC:TTC1) increases bp(GO:"protein folding")
pmid:24706768 a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis")
pmid:24706768 a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis")
pmid:25437566 p(HGNC:CCT5) causesNoChange a(HBP:"huntingtin aggregates")
pmid:25437566 p(HGNC:DNAJA4) increases a(HBP:"huntingtin aggregates")
pmid:25437566 p(HGNC:HSPA14) increases a(HBP:"huntingtin aggregates")
pmid:25437566 p(HGNC:CDC23) increases a(HBP:"huntingtin aggregates")
pmid:25437566 p(HGNC:CDC27) increases a(HBP:"huntingtin aggregates")
pmid:25036637 p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1))
pmid:29311797 p(HGNC:HSP90AB1) association bp(GO:"embryo development")
pmid:29311797 p(HGNC:HSP90AB1) association bp(GO:"cell maturation")
pmid:29311797 p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization")
pmid:29311797 p(HGNC:HSP90AB1) association bp(GO:"signal transduction")
pmid:29311797 p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway")
pmid:27491084 a(MESH:"Molecular Chaperones") decreases path(HBP:proteotoxicity)
pmid:23746257 a(MESH:"Molecular Chaperones") decreases a(MESH:"Protein Aggregates")
pmid:25784053 a(MESH:"Molecular Chaperones") decreases path(MESH:"Protein Aggregation, Pathological")
pmid:21882945 a(MESH:"Molecular Chaperones") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins")
pmid:29311797 a(MESH:"Molecular Chaperones") association bp(GO:"protein folding")
pmid:29311797 a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis)
pmid:27491084 bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
pmid:27491084 bp(HBP:Proteostasis) association p(HGNC:HSPD1)
pmid:27491084 bp(HBP:Proteostasis) association p(FPLX:HSPA)
pmid:27491084 bp(HBP:Proteostasis) association p(HGNC:TPR)
pmid:27491084 bp(HBP:Proteostasis) association p(FPLX:HSPB)
pmid:27491084 bp(HBP:Proteostasis) association p(FPLX:HSP90)
pmid:29311797 bp(HBP:Proteostasis) association p(FPLX:HSP90)
pmid:27491084 bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"AAA ATPases")
pmid:23746257 bp(HBP:Proteostasis) association bp(GO:"inflammatory response")
pmid:23746257 bp(HBP:Proteostasis) association bp(GO:"response to oxidative stress")
pmid:23746257 bp(HBP:Proteostasis) association bp(GO:"behavioral response to starvation")
pmid:23746257 bp(HBP:Proteostasis) negativeCorrelation bp(GO:"cell death")
pmid:25784053 bp(HBP:Proteostasis) association bp(MESH:"Protein Biosynthesis")
pmid:25784053 bp(HBP:Proteostasis) association bp(GO:"protein folding")
pmid:25784053 bp(HBP:Proteostasis) association path(MESH:"Protein Aggregation, Pathological")
pmid:25784053 bp(HBP:Proteostasis) association bp(MESH:Proteolysis)
pmid:25784053 bp(HBP:Proteostasis) decreases bp(MESH:Aging)
pmid:21882945 bp(HBP:Proteostasis) regulates p(HGNC:MAPT)
pmid:21882945 bp(HBP:Proteostasis) regulates a(MESH:Proteins)
pmid:27491084 p(HGNCGENEFAMILY:"AAA ATPases") association bp(HBP:Proteostasis)
pmid:27491084 p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration)
pmid:27491084 p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration)
pmid:27491084 p(HGNC:ATXN3, var("?")) association path(HP:Neurodegeneration)
pmid:23528736 p(HGNC:ATXN3, var("?")) association path(MESH:"Neurodegenerative Diseases")
pmid:14556719 p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A))
pmid:27491084 p(HGNC:AR, var("?")) association path(HP:Neurodegeneration)
pmid:30640040 p(HGNC:AR) association a(PUBCHEM:5833)
pmid:27491084 p(HGNC:SNCA, var("?")) association path(HP:Neurodegeneration)
pmid:29758300 p(HGNC:SNCA, var("?")) association bp(GO:"chaperone-mediated autophagy")
pmid:14556719 p(HGNC:SNCA, var("?")) association path(MESH:"Parkinsonian Disorders")
pmid:14556719 p(HGNC:SNCA, var("?")) increases bp(GO:"apoptotic process")
pmid:18930136 p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease")
pmid:18930136 p(HGNC:SNCA, var("?")) decreases tloc(p(HGNC:SNCA, var("?")), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen"))
pmid:30116051 p(HGNC:SNCA, var("?")) decreases bp(GO:"autophagosome assembly")
pmid:30116051 p(HGNC:SNCA, var("?")) decreases a(GO:"lysosomal membrane")
pmid:29758300 p(HGNC:SNCA) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:SNCA) increases path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:SNCA) increases path(MESH:"Parkinson Disease")
pmid:28803412 p(HGNC:SNCA) association path(MESH:"Parkinson Disease")
pmid:29758300 p(HGNC:SNCA) association bp(GO:"chaperone-mediated autophagy")
pmid:14556719 p(HGNC:SNCA) association p(HGNC:SNCAIP)
pmid:22908190 p(HGNC:SNCA) positiveCorrelation p(HGNC:SNCA, pmod(Ub))
pmid:14556719 p(HGNC:SNCA) regulates bp(GO:"dopamine secretion, neurotransmission")
pmid:14556719 p(HGNC:SNCA) regulates bp(GO:"dopamine secretion")
pmid:14556719 p(HGNC:SNCA) positiveCorrelation bp(HBP:"Alpha-synuclein Oligomerization")
pmid:14556719 p(HGNC:SNCA) increases bp(GO:"apoptotic process")
pmid:14556719 act(p(HGNC:SNCA)) increases p(HGNC:SNCAIP, pmod(Ub))
pmid:14556719 act(p(HGNC:SNCA)) increases p(HGNC:TH, pmod(Ub))
pmid:14556719 act(p(HGNC:SNCA)) regulates bp(GO:"homeostatic process")
pmid:14556719 p(HGNC:SNCA) association a(MESH:"Inclusion Bodies")
pmid:22908190 p(HGNC:SNCA) increases complex(a(GO:"Lewy body"), p(HGNC:SNCA))
pmid:25784053 p(HGNC:SNCA) decreases bp(GO:autophagy)
pmid:25784053 p(HGNC:SNCA) decreases p(HGNC:RAB1A)
pmid:25784053 path(MESH:"Protein Aggregation, Pathological") association bp(HBP:Proteostasis)
pmid:25784053 path(MESH:"Protein Aggregation, Pathological") association path(MESH:"Neurodegenerative Diseases")
pmid:25784053 path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1A)
pmid:25784053 path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1B)
pmid:25784053 path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:DNAJB1)
pmid:24706768 path(MESH:"Protein Aggregation, Pathological") decreases act(p(HGNC:HSPA8))
pmid:24706768 path(MESH:"Protein Aggregation, Pathological") decreases bp(GO:"clathrin-dependent endocytosis")
pmid:27574109 path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau")
pmid:27574109 path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau")
pmid:27574109 path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau")
pmid:27574109 path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau")
pmid:27574109 path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"Tau isoform F (441 aa)")
pmid:27491084 p(HGNC:STUB1) decreases path(HP:Neurodegeneration)
pmid:22908190 p(HGNC:STUB1) increases complex(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1))
pmid:25036637 p(HGNC:STUB1) increases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"))
pmid:25036637 p(HGNC:STUB1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:STUB1))
pmid:25374103 p(HGNC:STUB1) increases complex(p(FPLX:HSP90), p(HGNC:STUB1))
pmid:25036637 p(HGNC:STUB1) regulates bp(GO:"cellular protein catabolic process")
pmid:24027553 p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(Ub))
pmid:23528736 p(HGNC:STUB1) association path(MESH:"Neurodegenerative Diseases")
pmid:21882945 act(p(HGNC:STUB1)) increases bp(GO:"protein catabolic process")
pmid:21882945 act(p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination")
pmid:25374103 p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:25374103 p(HGNC:STUB1) regulates act(p(HGNC:CASP3))
pmid:25374103 p(HGNC:STUB1) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1))
pmid:25374103 p(HGNC:STUB1) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1))
pmid:25374103 p(HGNC:STUB1) increases deg(p(HBP:"Tau C3"))
pmid:25374103 p(HGNC:STUB1) negativeCorrelation p(HBP:"Tau C3")
pmid:25374103 p(HGNC:STUB1) increases deg(p(HBP:"Tau C3"))
pmid:25374103 p(HGNC:STUB1) causesNoChange bp(GO:"cell death")
pmid:25374103 p(HGNC:STUB1) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1))
pmid:25374103 p(HGNC:STUB1) increases complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(Ub)), p(HGNC:STUB1))
pmid:25374103 p(HGNC:STUB1) increases deg(p(HBP:"4R tau", var("p.Lys280del")))
pmid:25374103 p(HGNC:STUB1) negativeCorrelation act(p(FPLX:Caspase))
pmid:25374103 p(HGNC:STUB1) increases deg(p(FPLX:Caspase))
pmid:25374103 p(HGNC:STUB1) increases complex(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1))
pmid:29311797 p(HGNC:STUB1) association path(MESH:"Huntington Disease")
pmid:29311797 p(HGNC:STUB1) association path(MESH:"Parkinson Disease")
pmid:29311797 p(HGNC:STUB1) association path(MESH:"Alzheimer Disease")
pmid:29311797 p(HGNC:STUB1) association path(MESH:"Cystic Fibrosis")
pmid:29311797 p(HGNC:STUB1) association path(MESH:Neoplasms)
pmid:29311797 p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:29311797 p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:misfolding)))
pmid:26631930 p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK48))
pmid:14612456 p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2))
pmid:17954934 p(HGNC:STUB1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1))
pmid:25031639 act(p(HGNC:STUB1)) negativeCorrelation a(HBP:"Tau epitope, 12E8")
pmid:25031639 act(p(HGNC:STUB1)) increases deg(p(HGNC:MAPT))
pmid:27325702 p(HGNC:STUB1) association p(HBP:"APP, ACR")
pmid:27325702 p(HGNC:STUB1) isA complex(GO:"ubiquitin ligase complex")
pmid:27491084 p(UNIPROT:P15705) decreases path(HBP:proteotoxicity)
pmid:27491084 p(UNIPROT:P32589) regulates act(p(FPLX:HSPA))
pmid:27491084 p(UNIPROT:P32589) decreases path(HBP:proteotoxicity)
pmid:27491084 p(UNIPROT:P32589) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:27491084 p(HGNC:HSPB7) decreases path(HBP:proteotoxicity)
pmid:27491084 p(HGNC:HSPB7) decreases a(MESH:"Protein Aggregates")
pmid:27491084 p(UNIPROT:Q9XXG5) decreases path(HBP:proteotoxicity)
pmid:27491084 p(UNIPROT:Q9XXG5) decreases a(MESH:"Protein Aggregates")
pmid:27491084 p(UNIPROT:P12612) decreases path(HBP:proteotoxicity)
pmid:27491084 p(UNIPROT:P12612) decreases a(MESH:"Protein Aggregates")
pmid:27491084 p(UNIPROT:P02829) decreases path(HBP:proteotoxicity)
pmid:27491084 p(UNIPROT:P02829) decreases a(MESH:"Protein Aggregates")
pmid:23746257 bp(GO:"'de novo' protein folding") association act(p(HGNCGENEFAMILY:Chaperonins))
pmid:23746257 bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA))
pmid:23746257 bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA))
pmid:23746257 bp(GO:"'de novo' protein folding") association act(p(FPLX:HSP90))
pmid:27491084 bp(HBP:misfolding) association p(FPLX:HSPB)
pmid:24563850 bp(HBP:misfolding) increases path(MESH:"Protein Aggregation, Pathological")
pmid:29758300 a(HBP:"alpha-synuclein aggregates") association path(MESH:"Alzheimer Disease")
pmid:29758300 a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:14556719 a(HBP:"alpha-synuclein aggregates") association a(MESH:"Lewy Bodies")
pmid:14556719 a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Parkinsonian Disorders")
pmid:14556719 a(HBP:"alpha-synuclein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:27491084 p(HGNC:HSPB1) association a(HBP:"amyloid-beta aggregates")
pmid:21882945 p(HGNC:HSPB1) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins")
pmid:21882945 p(HGNC:HSPB1) increases bp(GO:"proteasomal protein catabolic process")
pmid:21882945 p(HGNC:HSPB1) increases bp(GO:autophagy)
pmid:21882945 p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:21882945 p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))
pmid:14963027 p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))
pmid:21882945 p(HGNC:HSPB1) increases p(HGNC:MAPT)
pmid:21882945 p(HGNC:HSPB1) decreases p(HGNC:MAPT)
pmid:14963027 p(HGNC:HSPB1) causesNoChange p(HGNC:MAPT)
pmid:21882945 p(HGNC:HSPB1) directlyIncreases complex(a(MESH:"Neurofibrillary Tangles"), p(HGNC:HSPB1))
pmid:21882945 p(HGNC:HSPB1) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:14963027 p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(Ph))
pmid:14963027 p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(Ph)))
pmid:14963027 p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process")
pmid:27491084 p(HGNC:CRYAB) association a(HBP:"amyloid-beta aggregates")
pmid:27491084 p(HGNC:HSPB6) association a(HBP:"amyloid-beta aggregates")
pmid:27491084 p(HGNC:HSF1) increases bp(HBP:Proteostasis)
pmid:21882945 p(HGNC:HSF1) increases bp(HBP:Proteostasis)
pmid:23746257 p(HGNC:HSF1) regulates bp(GO:"cellular response to stress")
pmid:23746257 p(HGNC:HSF1) increases a(MESH:"Molecular Chaperones")
pmid:25784053 act(p(HGNC:HSF1), ma(tscript)) increases a(MESH:"Molecular Chaperones")
pmid:23746257 p(HGNC:HSF1) decreases a(MESH:"Protein Aggregates")
pmid:25784053 act(p(HGNC:HSF1)) increases tloc(p(HGNC:HSF1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
pmid:25784053 act(p(HGNC:HSF1)) association path(MESH:Neoplasms)
pmid:24563850 p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins")
pmid:21882945 p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins")
pmid:30116051 act(p(HGNC:HSF1), ma(tscript)) increases act(p(FPLX:HSPA))
pmid:27491084 a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1A))
pmid:27491084 a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1B))
pmid:25784053 p(HGNC:HSPA1A) negativeCorrelation path(MESH:"Protein Aggregation, Pathological")
pmid:22817713 p(HGNC:HSPA1A) decreases a(HBP:"Tau aggregates")
pmid:22817713 p(HGNC:HSPA1A) increases deg(a(HBP:"Tau aggregates"))
pmid:25784053 p(HGNC:HSPA1B) negativeCorrelation path(MESH:"Protein Aggregation, Pathological")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:25784053 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates"))
pmid:29758300 bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates"))
pmid:29758300 bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation a(CHEBI:"amyloid-beta")
pmid:29758300 bp(GO:macroautophagy) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29758300 bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta")
pmid:29758300 bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta"))
pmid:29758300 bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta"))
pmid:29758300 bp(GO:macroautophagy) association p(HGNC:BECN1)
pmid:29758300 bp(GO:macroautophagy) increases path(MESH:"Plaque, Amyloid")
pmid:29758300 bp(GO:macroautophagy) increases deg(a(HBP:"Tau aggregates"))
pmid:29758300 bp(GO:macroautophagy) increases deg(a(CHEBI:triglyceride))
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Parkinson Disease")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Niemann-Pick Disease, Type C")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked")
pmid:29758300 bp(GO:macroautophagy) negativeCorrelation path(MESH:"Spastic Paraplegia, Hereditary")
pmid:22908190 bp(GO:macroautophagy) increases a(GO:autophagosome)
pmid:22908190 bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, frag("?")))
pmid:18930136 bp(GO:macroautophagy) increases bp(GO:"autophagosome-lysosome fusion")
pmid:18930136 bp(GO:macroautophagy) increases deg(p(HGNC:SNCA))
pmid:30116051 bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(HBP:HBP00007)))
pmid:29024336 bp(GO:macroautophagy) increases deg(p(MGI:Mapt))
pmid:29024336 bp(GO:macroautophagy) decreases deg(p(MGI:Mapt))
pmid:29024336 bp(GO:macroautophagy) increases deg(p(MGI:Mapt, var("p.Ala152Thr")))
pmid:29024336 bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu")))
pmid:29024336 bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu")))
pmid:29024336 bp(GO:macroautophagy) increases deg(a(MESH:Proteins))
pmid:26751493 bp(GO:macroautophagy) decreases p(HGNC:MAPT)
pmid:22908190 a(GO:autophagosome) association a(HBP:"dystrophic neurite")
pmid:22908190 a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:18930136 a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:18930136 a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 a(GO:autophagosome) increases a(GO:organelle)
pmid:22908190 a(GO:autophagosome) association p(HGNC:APP)
pmid:18930136 a(GO:autophagosome) increases bp(GO:autophagy)
pmid:18930136 a(GO:autophagosome) increases bp(GO:"autophagosome-lysosome fusion")
pmid:18930136 a(GO:autophagosome) increases complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome))
pmid:18930136 a(GO:autophagosome) association complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B))
pmid:18930136 a(GO:autophagosome) positiveCorrelation path(MESH:"Parkinson Disease")
pmid:18930136 a(GO:autophagosome) positiveCorrelation path(MESH:"Creutzfeldt-Jakob Syndrome")
pmid:18930136 a(GO:autophagosome) negativeCorrelation p(HGNC:CTSD)
pmid:18930136 a(GO:autophagosome) positiveCorrelation p(HGNC:DCTN1, var("?"))
pmid:22908190 a(HBP:"dystrophic neurite") association a(HBP:"paired helical filaments")
pmid:22908190 a(HBP:"dystrophic neurite") association a(MESH:Ubiquitin)
pmid:22908190 a(HBP:"dystrophic neurite") association a(GO:autophagosome)
pmid:22908190 a(HBP:"dystrophic neurite") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 a(GO:autolysosome) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:18930136 a(GO:autolysosome) positiveCorrelation path(MESH:"Huntington Disease")
pmid:18930136 a(GO:autolysosome) decreases path(HBP:Neurodegeneration)
pmid:29758300 bp(GO:"lysosomal protein catabolic process") decreases a(GO:autolysosome)
pmid:29758300 bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy)
pmid:22908190 bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy)
pmid:22908190 bp(GO:"lysosomal protein catabolic process") negativeCorrelation act(p(HGNC:RAB5A))
pmid:22908190 bp(GO:"lysosomal protein catabolic process") increases bp(GO:"axonal transport")
pmid:22908190 bp(GO:"lysosomal protein catabolic process") negativeCorrelation bp(GO:endocytosis)
pmid:22908190 bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration)
pmid:22908190 bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration)
pmid:22908190 bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:MAP1LC3B)
pmid:22908190 bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:SQSTM1)
pmid:22908190 bp(GO:"lysosomal protein catabolic process") decreases p(MESH:Proteins, pmod(Ub))
pmid:22908190 bp(GO:"lysosomal protein catabolic process") increases deg(a(MESH:"Amyloid beta-Peptides"))
pmid:22908190 bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta"))
pmid:22908190 bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta"))
pmid:22908190 bp(GO:"lysosomal protein catabolic process") decreases a(CHEBI:"amyloid-beta")
pmid:22908190 bp(GO:"lysosomal protein catabolic process") increases bp(GO:learning)
pmid:22908190 bp(GO:"lysosomal protein catabolic process") increases bp(GO:memory)
pmid:29758300 p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle")
pmid:30116051 p(HGNC:BECN1, frag("?")) decreases act(p(HGNC:BECN1))
pmid:29758300 bp(GO:"regulation of lysosomal lumen pH") association p(HGNC:PSEN1)
pmid:22908190 a(GO:lysosome) increases deg(p(MESH:Proteins, pmod(Ub)))
pmid:22908190 a(GO:lysosome) increases deg(p(HGNC:MAPT))
pmid:22908190 a(GO:lysosome) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 act(a(GO:lysosome)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 a(GO:lysosome) increases a(GO:organelle)
pmid:18930136 a(GO:lysosome) negativeCorrelation p(HGNC:CTSD)
pmid:18930136 act(a(GO:lysosome)) decreases path(HBP:Neurodegeneration)
pmid:18930136 act(a(GO:lysosome)) increases a(GO:autophagosome)
pmid:18930136 act(a(GO:lysosome)) increases a(GO:lysosome)
pmid:18930136 act(a(GO:lysosome)) negativeCorrelation path(MESH:"Neuronal Ceroid-Lipofuscinoses")
pmid:29024336 a(GO:lysosome) increases deg(a(HBP:HBP00053))
pmid:29590627 a(GO:lysosome) association p(HGNC:MAPT, var("p.Pro301Ser"))
pmid:29590627 a(GO:lysosome) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 a(GO:lysosome) association a(HBP:"Tau aggregates")
pmid:29590627 a(GO:lysosome) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:24561250 a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:29758300 p(MESH:Proteins, pmod(HBP:misfolding)) decreases bp(GO:"neuron cellular homeostasis")
pmid:29758300 p(MESH:Proteins, pmod(HBP:misfolding)) decreases a(MESH:Neurons)
pmid:14556719 p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(GO:"response to unfolded protein")
pmid:24457024 p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(HBP:"protein aggregation")
pmid:18930136 p(MESH:Proteins, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Neurodegenerative Diseases")
pmid:18930136 p(MESH:Proteins, pmod(HBP:misfolding)) increases p(HGNC:SQSTM1)
pmid:29758300 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration)
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration)
pmid:29758300 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases path(MESH:Tauopathies)
pmid:29758300 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates")
pmid:23528736 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates")
pmid:29758300 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA))
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA))
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA))
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Parkinson Disease")
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7))
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases")
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases")
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:aging)
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP))
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?")))
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?")))
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?")))
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases a(HBP:"protein aggregates")
pmid:14556719 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?")))
pmid:22908190 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(Ub)))
pmid:22908190 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:"regulation of synaptic plasticity")
pmid:30116051 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"regulation of synaptic plasticity")
pmid:22908190 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:learning)
pmid:22908190 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:memory)
pmid:30116051 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:memory)
pmid:22908190 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:ARC))
pmid:22908190 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"long-term memory")
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates bp(GO:"amino acid homeostasis")
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process")
pmid:29626319 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process")
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases rxn(reactants(a(MESH:Proteins)), products(a(CHEBI:oligopeptide)))
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"ubiquitin recycling")
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:autophagy)
pmid:18930136 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm))
pmid:30116051 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT))
pmid:23528736 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association deg(p(HGNC:MAPT))
pmid:25374103 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT))
pmid:30116051 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"dendrite development")
pmid:29626319 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins))
pmid:29626319 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HBP:"Tau oligomers", pmod(HBP:hyperphosphorylation))
pmid:29758300 bp(GO:proteolysis) decreases bp(GO:"neuron death")
pmid:14556719 bp(GO:proteolysis) association p(HGNC:UBA3)
pmid:29626319 bp(GO:proteolysis) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29758300 bp(GO:"chaperone-mediated autophagy") decreases a(HBP:"protein aggregates")
pmid:29758300 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT))
pmid:22908190 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT))
pmid:30116051 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT))
pmid:30116051 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT))
pmid:29758300 bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA)
pmid:29758300 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA))
pmid:18930136 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA))
pmid:18930136 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA))
pmid:18930136 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA))
pmid:30116051 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA))
pmid:30116051 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA))
pmid:29758300 bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA, var("?"))
pmid:22908190 bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen"))
pmid:18930136 bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen"))
pmid:24563850 bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Protein Aggregation, Pathological")
pmid:30116051 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP))
pmid:30116051 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:APP))
pmid:30116051 bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:30116051 bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT))
pmid:30116051 bp(GO:"chaperone-mediated autophagy") increases act(p(HGNC:MEF2D))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr")))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr")))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr")))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu")))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu")))
pmid:29024336 bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies")
pmid:25374103 bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded)))
pmid:29311797 bp(GO:"chaperone-mediated autophagy") association p(FPLX:HSP90)
pmid:29311797 bp(GO:"chaperone-mediated autophagy") association p(HGNC:STIP1)
pmid:29758300 p(MESH:"Amyloid beta-Peptides", pmod(HBP:misfolding)) increases path(MESH:"Alzheimer Disease")
pmid:29758300 act(complex(GO:"TOR complex")) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:29626319 complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy")
pmid:29758300 bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 bp(GO:endocytosis) association p(HGNC:BECN1)
pmid:22908190 bp(GO:endocytosis) increases tloc(a(GO:"intrinsic component of plasma membrane"), fromLoc(GO:"plasma membrane"), toLoc(GO:lysosome))
pmid:22908190 bp(GO:endocytosis) increases act(a(MESH:Neurons))
pmid:22908190 bp(GO:endocytosis) association bp(GO:"regulation of synaptic plasticity")
pmid:22908190 bp(GO:endocytosis) increases bp(GO:memory)
pmid:22908190 bp(GO:endocytosis) increases bp(GO:learning)
pmid:22908190 bp(GO:endocytosis) increases bp(MESH:"Synaptic Transmission")
pmid:22908190 bp(GO:endocytosis) positiveCorrelation p(HGNC:APP)
pmid:22908190 bp(GO:endocytosis) positiveCorrelation g(HBP:"APOE e4")
pmid:22908190 bp(GO:endocytosis) positiveCorrelation a(CHEBI:cholesterol)
pmid:22908190 bp(GO:endocytosis) positiveCorrelation a(MESH:Proteins)
pmid:22908190 bp(GO:endocytosis) positiveCorrelation a(CHEBI:lipid)
pmid:22908190 bp(GO:endocytosis) negativeCorrelation bp(GO:"lysosomal protein catabolic process")
pmid:22908190 bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:22908190 bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:22908190 bp(GO:endocytosis) positiveCorrelation act(a(GO:synapse))
pmid:22908190 bp(GO:endocytosis) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
pmid:22908190 bp(GO:endocytosis) positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome))
pmid:18930136 bp(GO:endocytosis) increases a(GO:lysosome)
pmid:29590627 bp(GO:endocytosis) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:28420982 bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:endosome), toLoc(GO:lysosome))
pmid:29686391 bp(GO:endocytosis) positiveCorrelation bp(GO:"mitotic G1 phase")
pmid:29758300 p(HGNC:ATG7) increases bp(GO:macroautophagy)
pmid:18930136 p(HGNC:ATG7) decreases path(HBP:Neurodegeneration)
pmid:29758300 path(MESH:"Niemann-Pick Diseases") association p(HGNC:MAPT)
pmid:22908190 path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"UBB+1")
pmid:26751493 path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau")
pmid:26631930 path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau")
pmid:26751493 path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val"))
pmid:26631930 path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:29758300 p(FPLX:MAPK) increases p(HGNC:MAPT, pmod(Ph))
pmid:29191965 p(FPLX:MAPK) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:8702879 act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 62))
pmid:8702879 act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 67))
pmid:8702879 act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551))
pmid:29758300 composite(p(HGNC:HSPA8), p(HGNC:LAMP2)) increases tloc(p(HGNC:MAPT), fromLoc(GO:cytosol), toLoc(GO:lysosome))
pmid:18930136 p(HGNC:LAMP2) increases tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome))
pmid:30116051 p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy")
pmid:30116051 p(HGNC:LAMP2) increases deg(p(HGNC:SNCA))
pmid:29758300 p(HGNC:NBR1) association p(HGNC:MAPT)
pmid:29758300 p(HGNC:SNCA, pmod(HBP:misfolding)) increases a(HBP:"alpha-synuclein oligomers")
pmid:29758300 a(HBP:"alpha-synuclein oligomers") increases path(HBP:neuroinflammation)
pmid:29758300 a(HBP:"alpha-synuclein oligomers") increases bp(GO:"cell death")
pmid:29758300 complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala53Thr"))) decreases bp(GO:"lysosomal protein catabolic process")
pmid:14556719 p(HGNC:SNCA, var("p.Ala53Thr")) association path(MESH:"Parkinson Disease")
pmid:28803412 p(HGNC:SNCA, var("p.Ala53Thr")) increases path(MESH:"Parkinson Disease")
pmid:14556719 p(HGNC:SNCA, var("p.Ala53Thr")) increases a(HBP:"alpha-synuclein fibrils")
pmid:29758300 complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala30Pro"))) decreases bp(GO:"lysosomal protein catabolic process")
pmid:14556719 p(HGNC:SNCA, var("p.Ala30Pro")) association path(MESH:"Parkinson Disease")
pmid:28803412 p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Parkinson Disease")
pmid:14556719 p(HGNC:SNCA, var("p.Ala30Pro")) increases a(HBP:"alpha-synuclein fibrils")
pmid:28803412 p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Lewy Body Disease")
pmid:29758300 p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:29758300 p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:29334120 act(p(HGNC:TARDBP)) increases p(HBP:"4R tau")
pmid:29758300 a(CHEBI:lipid) regulates bp(GO:"energy homeostasis")
pmid:29758300 a(CHEBI:lipid) regulates bp(GO:"intracellular signal transduction")
pmid:29758300 a(CHEBI:lipid) regulates bp(GO:macroautophagy)
pmid:29758300 a(CHEBI:lipid) regulates bp(GO:"amyloid-beta metabolic process")
pmid:29758300 a(CHEBI:lipid) negativeCorrelation bp(GO:autophagy)
pmid:22908190 a(CHEBI:lipid) positiveCorrelation act(p(HGNC:RAB5A))
pmid:22908190 a(CHEBI:lipid) positiveCorrelation bp(GO:endocytosis)
pmid:29758300 path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid")))
pmid:29758300 path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus))
pmid:29758300 path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein"))
pmid:18930136 path(MESH:Starvation) increases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm))
pmid:29238289 path(MESH:Starvation) increases p(HGNC:MAPT)
pmid:24561250 a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex"))
pmid:29758300 rxn(reactants(a(MESH:Sphingomyelins)), products(a(CHEBI:ceramide))) increases a(CHEBI:"amyloid-beta")
pmid:29758300 a(CHEBI:sphingolipid) regulates act(complex(GO:"gamma-secretase complex"))
pmid:29758300 complex(a(CHEBI:lipid), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates")
pmid:29758300 complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) association a(HBP:"Tau aggregates")
pmid:29758300 p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph))
pmid:23528736 p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph))
pmid:30116051 p(FPLX:AMPK) increases bp(GO:macroautophagy)
pmid:30116051 p(FPLX:AMPK) decreases bp(GO:mitophagy)
pmid:30116051 p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 317))
pmid:30116051 p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 777))
pmid:30116051 p(FPLX:AMPK) increases p(FPLX:mTORC1, pmod(Ph))
pmid:30116051 p(FPLX:AMPK) increases a(CHEBI:"NAD(+)")
pmid:30116051 act(p(FPLX:AMPK)) increases bp(GO:autophagy)
pmid:30116051 act(p(FPLX:AMPK)) increases bp(GO:autophagy)
pmid:23528736 p(FPLX:AMPK) increases bp(GO:autophagy)
pmid:30116051 act(p(FPLX:AMPK)) increases act(p(HGNC:SIRT1))
pmid:23528736 p(FPLX:AMPK) decreases act(p(FPLX:mTORC1))
pmid:30116051 p(HGNC:ULK1) increases bp(GO:macroautophagy)
pmid:30116051 act(p(HGNC:ULK1)) increases bp(GO:"autophagosome assembly")
pmid:30116051 act(p(HGNC:ULK1)) increases p(HGNC:AMBRA1, pmod(Ph))
pmid:30116051 act(p(HGNC:ULK1)) increases p(HGNC:BECN1, pmod(Ph))
pmid:23528736 p(HGNC:ULK1) increases bp(GO:autophagy)
pmid:29758300 composite(p(FPLX:AMPK), p(HGNC:TSC2)) decreases act(p(HGNC:MTOR))
pmid:29758300 p(HGNC:PRKAA1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:29758300 p(HGNC:TFEB) regulates a(GO:lysosome)
pmid:29626319 p(HGNC:TFEB) increases act(a(GO:lysosome))
pmid:29626319 p(HGNC:TFEB) increases act(a(GO:lysosome))
pmid:29758300 p(HGNC:TFEB) regulates bp(GO:autophagy)
pmid:29758300 p(HGNC:TFEB) increases bp(GO:autophagy)
pmid:29626319 p(HGNC:TFEB) increases bp(GO:autophagy)
pmid:29758300 p(HGNC:TFEB) association path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:TFEB) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:29626319 p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(Ph)))
pmid:29758300 p(HGNC:TFEB) increases act(p(HGNC:PTEN))
pmid:28803412 p(HGNC:TFEB) decreases a(HBP:HBP00093)
pmid:30116051 p(HGNC:TFEB) increases bp(GO:macroautophagy)
pmid:30116051 tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy)
pmid:30116051 p(HGNC:TFEB) decreases a(HBP:HBP00018)
pmid:30108137 p(HGNC:TFEB) decreases act(a(MESH:Lysosomes))
pmid:29626319 p(HGNC:TFEB) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 p(HGNC:TFEB) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:TFEB) regulates deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid")
pmid:29626319 p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles"))
pmid:29758300 p(HGNC:TFEB, pmod(Ph)) decreases act(p(HGNC:TFEB))
pmid:29758300 complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases bp(GO:macroautophagy)
pmid:29758300 complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases a(GO:lysosome)
pmid:29758300 bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus))
pmid:29758300 bp(GO:"cellular response to stress") increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein"))
pmid:18930136 bp(GO:"cellular response to stress") increases p(HGNC:SQSTM1)
pmid:21882945 bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins")
pmid:21882945 bp(GO:"cellular response to stress") increases a(HBP:"Hsp27 oligomers")
pmid:29758300 p(HGNC:PTEN) increases bp(GO:macroautophagy)
pmid:29758300 composite(p(HGNC:PTEN), p(HGNC:TFEB)) increases bp(GO:macroautophagy)
pmid:29758300 p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:PICALM) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:29758300 p(HGNC:PICALM) increases a(CHEBI:"amyloid-beta")
pmid:29758300 p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Endothelial Cells"), toLoc(MESH:Blood))
pmid:29626319 p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Blood-Brain Barrier"), toLoc(MESH:Blood))
pmid:29626319 p(HGNC:PICALM) decreases a(CHEBI:"amyloid-beta")
pmid:29758300 p(HGNC:PICALM) increases path(MESH:"Plaque, Amyloid")
pmid:29758300 p(HGNC:PICALM) increases bp(GO:"clathrin-dependent endocytosis")
pmid:29758300 p(HGNC:PICALM) increases tloc(complex(GO:"gamma-secretase complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular))
pmid:29758300 p(HGNC:PICALM) regulates bp(GO:macroautophagy)
pmid:29758300 p(HGNC:PICALM) increases tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular))
pmid:26195256 p(HGNC:PICALM) association path(MESH:"Alzheimer Disease")
pmid:29626319 p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:27260836 p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:27260836 p(HGNC:PICALM) increases complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits"))
pmid:27260836 p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle")
pmid:27260836 p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle")
pmid:27260836 p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph))
pmid:27260836 p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph))
pmid:27260836 p(HGNC:PICALM) partOf a(HBP:"granulovacuolar degeneration")
pmid:27260836 p(HGNC:PICALM) partOf complex(GO:"Pick body")
pmid:27260836 p(HGNC:PICALM) partOf complex(GO:"Cajal body")
pmid:27260836 p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B)
pmid:27260836 p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1)
pmid:29758300 tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) increases deg(a(HBP:"Tau aggregates"))
pmid:29758300 p(HGNC:BIN1) increases bp(GO:endocytosis)
pmid:29758300 p(HGNC:BIN1) increases bp(GO:"amyloid precursor protein metabolic process")
pmid:29758300 p(HGNC:BIN1) increases bp(GO:autophagy)
pmid:29758300 p(HGNC:BIN1) decreases a(CHEBI:"amyloid-beta")
pmid:29758300 p(HGNC:BIN1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:BIN1) positiveCorrelation path(MESH:Tauopathies)
pmid:29758300 p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT)
pmid:29758300 p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:29758300 p(HGNC:TREM2) increases bp(GO:macroautophagy)
pmid:29758300 p(HGNC:TREM2) increases bp(GO:"metabolic process")
pmid:29758300 p(HGNC:TREM2) increases bp(GO:"metabolic process")
pmid:29758300 p(HGNC:TREM2) increases act(complex(GO:"TOR complex"))
pmid:26195256 p(HGNC:TREM2) association path(MESH:"Alzheimer Disease")
pmid:29626319 p(HGNC:TREM2) association bp(GO:phagocytosis)
pmid:29626319 act(p(HGNC:TREM2)) increases bp(GO:phagocytosis)
pmid:29626319 act(p(HGNC:TREM2)) increases deg(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:29758300 p(HGNC:TREM2, var("?")) increases path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:VPS35) regulates act(p(HGNC:TREM2))
pmid:29758300 p(HGNC:VPS35) directlyIncreases complex(p(HGNC:SORL1), p(HGNC:VPS35))
pmid:29758300 p(HGNC:VPS35, var("?")) decreases bp(GO:macroautophagy)
pmid:29758300 p(HGNC:VPS35, var("?")) decreases act(a(GO:mitochondrion))
pmid:29758300 p(HGNC:VPS35, var("?")) association path(MESH:"Alzheimer Disease")
pmid:29758300 p(HGNC:VPS35, var("?")) association path(MESH:"Parkinson Disease")
pmid:29758300 a(GO:mitochondrion) regulates bp(GO:"energy homeostasis")
pmid:27671637 a(GO:mitochondrion) positiveCorrelation a(CHEBI:ATP)
pmid:25987199 act(a(GO:mitochondrion)) positiveCorrelation act(p(MGI:Ppargc1a))
pmid:22952452 act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:TRAK1)
pmid:22952452 act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:RHOT1)
pmid:18930136 bp(GO:mitophagy) isA bp(GO:macroautophagy)
pmid:30116051 bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?"))
pmid:29758300 p(HGNC:PSEN1, var("p.Met146Leu")) decreases bp(GO:autophagy)
pmid:29758300 p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:autophagy)
pmid:29758300 p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:mitophagy)
pmid:29758300 p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(a(GO:lysosome))
pmid:29758300 p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:29758300 p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:29758300 p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:macroautophagy)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse")
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:MAPT)
pmid:26631930 p(HGNC:MAPT, var("p.Ala152Thr")) decreases act(p(HGNC:MAPT))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:DLGAP4)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(MESH:"Membrane Potentials")
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation")
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP2))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:"neuron death")
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph))
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:HBP00045)
pmid:27594586 p(HGNC:MAPT, var("p.Ala152Thr")) decreases a(HBP:HBP00044)
pmid:29024336 p(HGNC:MAPT, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt))
pmid:29191965 p(HGNC:MAPT, var("p.Ala152Thr")) association path(MESH:"Supranuclear Palsy, Progressive")
pmid:26631930 p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:26631930 p(HGNC:MAPT, var("p.Ala152Thr")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"microtubule polymerization")
pmid:26631930 p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:"Tau oligomers")
pmid:29758300 composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"cell death")
pmid:27594586 composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"neuron death")
pmid:29758300 path(MESH:"Niemann-Pick Disease, Type C") negativeCorrelation bp(GO:macroautophagy)
pmid:29758300 path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:macroautophagy)
pmid:14556719 path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
pmid:14556719 path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
pmid:18930136 path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:autophagy)
pmid:29758300 path(MESH:"Spastic Paraplegia, Hereditary") negativeCorrelation bp(GO:macroautophagy)
pmid:29758300 a(CHEBI:Temsirolimus) increases bp(GO:macroautophagy)
pmid:30116051 a(CHEBI:Temsirolimus) decreases a(HBP:HBP00006)
pmid:30116051 a(CHEBI:Temsirolimus) decreases a(HBP:HBP00017)
pmid:30116051 a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior")
pmid:30116051 a(CHEBI:Temsirolimus) decreases a(HBP:HBP00016)
pmid:30116051 a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration)
pmid:30116051 a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?"))
pmid:29626319 a(CHEBI:Temsirolimus) increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:Temsirolimus) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(Ph))
pmid:29758300 a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy)
pmid:18930136 a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy)
pmid:30145931 a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy)
pmid:23528736 a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy)
pmid:18930136 a(CHEBI:"alpha,alpha-trehalose") decreases path(HBP:Neurodegeneration)
pmid:30145931 a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT)
pmid:30145931 a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT, loc(MESH:Dendrites))
pmid:29626319 a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT)
pmid:30145931 a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates")
pmid:23528736 a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates")
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") decreases act(p(HGNC:SLC2A9))
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") increases act(p(FPLX:AMPK))
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") decreases bp(HP:Neurodegeneration)
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00006)
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00016)
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00017)
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00018)
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:"motor behavior")
pmid:30116051 a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:cognition)
pmid:23528736 a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process")
pmid:29626319 a(CHEBI:"alpha,alpha-trehalose") decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(CHEBI:"alpha,alpha-trehalose") increases p(HGNC:BAG3)
pmid:29311797 p(HGNC:MAPT, pmod(HBP:misfolding)) increases bp(GO:"cell death in response to oxidative stress")
pmid:18930136 p(HGNC:MAP1LC3B) increases complex(a(GO:autophagosome), p(HGNC:MAP1LC3B))
pmid:18930136 p(HGNC:MAP1LC3B) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B))
pmid:27260836 p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM)
pmid:29758300 a(CHEBI:paclitaxel) increases a(GO:microtubule)
pmid:30116051 a(CHEBI:paclitaxel) increases a(GO:microtubule)
pmid:29758300 a(CHEBI:paclitaxel) increases tloc(a(GO:autophagosome), fromLoc(GO:"extracellular space"), toLoc(MESH:Neurons))
pmid:22941973 a(CHEBI:paclitaxel) negativeCorrelation act(p(INTERPRO:"14-3-3 domain"))
pmid:22941973 a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(Ph, Ser, 262))
pmid:29758300 a(CHEBI:epothilone) decreases path(MESH:Tauopathies)
pmid:29758300 a(CHEBI:epothilone) increases bp(GO:cognition)
pmid:14556719 composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin))
pmid:22908190 composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin))
pmid:14556719 act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA1))
pmid:22908190 a(MESH:Ubiquitin) association a(HBP:"paired helical filaments")
pmid:22908190 a(MESH:Ubiquitin) association a(GO:"neurofibrillary tangle")
pmid:22908190 a(MESH:Ubiquitin) association a(HBP:"dystrophic neurite")
pmid:22908190 a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration")
pmid:22908190 a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration")
pmid:22908190 a(MESH:Ubiquitin) association a(MESH:"Neuropil Threads")
pmid:22908190 a(MESH:Ubiquitin) association a(GO:"Lewy body")
pmid:22908190 a(MESH:Ubiquitin) association a(GO:"Lewy body")
pmid:22908190 a(MESH:Ubiquitin) association a(GO:"Pick body")
pmid:22908190 act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2))
pmid:22908190 a(MESH:Ubiquitin) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body"))
pmid:24457024 a(MESH:Ubiquitin) regulates bp(GO:signaling)
pmid:24457024 a(MESH:Ubiquitin) regulates bp(GO:endocytosis)
pmid:24457024 a(MESH:Ubiquitin) regulates bp(GO:macroautophagy)
pmid:24457024 a(MESH:Ubiquitin) regulates bp(GO:"DNA repair")
pmid:24457024 act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis")
pmid:24457024 complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2))
pmid:24457024 complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2))
pmid:14556719 p(HGNC:UBA2) decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA1))
pmid:14556719 p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3))
pmid:14556719 p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(INTERPRO:"HECT domain"))
pmid:14556719 act(p(HGNC:UBA2)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:14556719 p(HGNC:UBA2) increases p(HGNC:HTT, pmod(Ub))
pmid:24457024 p(HGNC:UBA2) increases bp(GO:"protein ubiquitination")
pmid:24457024 complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) increases act(p(HGNC:UBA2))
pmid:14556719 p(HGNC:UBA3) increases bp(GO:"protein ubiquitination")
pmid:14556719 p(HGNC:UBA3) increases bp(GO:"protein ubiquitination")
pmid:24457024 p(HGNC:UBA3) increases bp(GO:"protein ubiquitination")
pmid:24457024 p(HGNC:UBA3) increases bp(GO:"protein ubiquitination")
pmid:24457024 p(HGNC:UBA3) increases bp(GO:"protein ubiquitination")
pmid:14556719 p(HGNC:UBA3) association bp(GO:proteolysis)
pmid:22908190 p(HGNC:UBA3) increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3))
pmid:24457024 p(HGNC:UBA3) increases act(p(HGNC:UBA2))
pmid:24457024 p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2))
pmid:24457024 p(HGNC:UBA3) regulates bp(GO:"protein polyubiquitination")
pmid:24457024 p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3))
pmid:14556719 p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2))
pmid:14556719 p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3))
pmid:24457024 p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3))
pmid:24457024 complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) increases act(p(HGNC:UBA2))
pmid:22908190 a(MESH:Proteins) positiveCorrelation act(p(HGNC:RAB5A))
pmid:22908190 a(MESH:Proteins) positiveCorrelation bp(GO:endocytosis)
pmid:24457024 tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) increases act(p(HGNC:PSMD14))
pmid:18930136 tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) increases deg(a(MESH:Proteins))
pmid:14556719 bp(GO:"protein ubiquitination") increases bp(GO:"lysosomal protein catabolic process")
pmid:14556719 bp(GO:"protein ubiquitination") increases bp(GO:"protein catabolic process in the vacuole")
pmid:14556719 bp(GO:"protein ubiquitination") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:18930136 bp(GO:"protein ubiquitination") regulates bp(GO:autophagy)
pmid:14556719 bp(GO:"protein K48-linked ubiquitination") increases act(complex(GO:"proteasome complex"))
pmid:14556719 bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex"))
pmid:22908190 bp(GO:"protein K63-linked ubiquitination") association a(GO:"neurofibrillary tangle")
pmid:18930136 bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:SQSTM1))
pmid:18930136 bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:HDAC6))
pmid:18930136 bp(GO:"protein K63-linked ubiquitination") increases bp(GO:autophagy)
pmid:14556719 p(HGNC:MOCS3) increases bp(GO:"protein polyubiquitination")
pmid:22908190 p(HBP:"20 S Proteasome") increases deg(p(HGNC:MAPT))
pmid:22908190 p(HBP:"20 S Proteasome") increases complex(a(HBP:"Tau aggregates"), p(HBP:"20 S Proteasome"))
pmid:16816118 act(p(HBP:"20 S Proteasome")) negativeCorrelation p(RGD:Mapt, pmod(HBP:nitration))
pmid:16816118 act(p(HBP:"20 S Proteasome")) negativeCorrelation bp(GO:"neurofibrillary tangle assembly")
pmid:14556719 complex(GO:"proteasome regulatory particle") increases bp(GO:"protein unfolding")
pmid:14556719 p(HGNC:PSMD4) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMD4))
pmid:14556719 p(HGNC:PSMD4) association p(HGNC:PRKN)
pmid:24457024 p(HGNC:PSMD4) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub)))
pmid:25036637 p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1), p(HGNC:PSMD4))
pmid:25036637 p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD4), p(HGNC:USP14))
pmid:25036637 p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD4))
pmid:25036637 p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:PSMD4))
pmid:25036637 p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PRPS2), p(HGNC:PSMD4))
pmid:25036637 p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMA5), p(HGNC:PSMD4))
pmid:14556719 p(HGNC:PSMC3) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMC3))
pmid:14556719 deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(MESH:Ubiquitin)
pmid:14556719 deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(CHEBI:peptide)
pmid:14556719 complex(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases bp(GO:"protein stabilization")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell cycle")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell division")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell differentiation")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cellular response to stress")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Receptors, Cell Surface")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Ion Channels")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Secretory Pathway")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"DNA repair")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"gene silencing")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"long-term memory")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"circadian rhythm")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"immune response")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"inflammatory response")
pmid:14556719 bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"organelle organization")
pmid:25036637 bp(GO:"gene silencing") association p(HGNC:DCP1A)
pmid:25036637 bp(GO:"gene silencing") association p(HGNC:EDC3)
pmid:25036637 bp(GO:"gene silencing") association p(HGNC:DDX6)
pmid:14556719 bp(GO:"protein catabolic process") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:23746257 bp(GO:"protein catabolic process") association act(p(FPLX:HSPA))
pmid:14556719 path(MESH:Cachexia) increases bp(GO:"protein catabolic process")
pmid:14556719 path(MESH:Sepsis) increases bp(GO:"protein catabolic process")
pmid:14556719 path(MESH:Acidosis) increases bp(GO:"protein catabolic process")
pmid:14556719 a(MESH:Denervation) increases bp(GO:"protein catabolic process")
pmid:14556719 p(HGNC:NEDD8) increases complex(a(GO:"SCF ubiquitin ligase complex"), p(HGNC:UBA2))
pmid:14556719 p(HGNC:SUMO1) increases p(HGNC:NFKBIA, pmod(Sumo))
pmid:27716675 p(HGNC:SUMO1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23229893 p(HGNC:SUMO1) partOf a(GO:lysosome)
pmid:19323834 p(HGNC:SUMO1) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1))
pmid:18675254 p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 587))
pmid:18675254 p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 595))
pmid:16464864 p(HGNC:SUMO1) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340))
pmid:16464864 p(HGNC:SUMO1) increases p(HGNC:SNCA, pmod(Sumo))
pmid:14556719 p(HGNC:NFKBIA, pmod(Sumo)) decreases bp(GO:"protein ubiquitination")
pmid:14556719 p(UNIPROT:P32628) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex"))
pmid:22908190 p(MESH:Proteins, pmod(Ub)) increases deg(p(MESH:Proteins, pmod(Ub)))
pmid:22908190 p(MESH:Proteins, pmod(Ub)) increases complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub)))
pmid:14556719 p(UNIPROT:P48510) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex"))
pmid:14556719 complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles")
pmid:14556719 complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body")
pmid:14556719 complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease")
pmid:14556719 complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias")
pmid:14556719 complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked")
pmid:14556719 complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies")
pmid:14556719 a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders")
pmid:14556719 a(MESH:"Inclusion Bodies") association p(HGNC:SNCA)
pmid:14556719 a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP)
pmid:14556719 complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles")
pmid:14556719 complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body")
pmid:14556719 complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease")
pmid:14556719 complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias")
pmid:14556719 complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked")
pmid:14556719 complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies")
pmid:14556719 a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
pmid:14556719 a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
pmid:14556719 path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
pmid:14556719 path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
pmid:14556719 a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin))
pmid:14556719 a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies"))
pmid:14556719 a(MESH:"Lewy Bodies") association a(GO:"dopaminergic synapse")
pmid:14556719 a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders")
pmid:14556719 a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders")
pmid:14556719 a(MESH:"Lewy Bodies") association a(HBP:"alpha-synuclein aggregates")
pmid:14556719 a(MESH:"Lewy Bodies") association path(MESH:"Parkinson Disease")
pmid:14556719 a(GO:"dopaminergic synapse") association a(MESH:"Lewy Bodies")
pmid:14556719 p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease")
pmid:14556719 p(HGNC:PRKN) association p(HGNC:PSMD4)
pmid:14556719 p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission")
pmid:14556719 p(HGNC:PRKN) negativeCorrelation a(MESH:"Dopaminergic Neurons")
pmid:14556719 p(HGNC:PRKN) increases p(HGNC:SEPT5, pmod(Ub))
pmid:14556719 p(HGNC:PRKN) association p(HGNC:GPR37)
pmid:14556719 p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein")
pmid:14556719 p(HGNC:PRKN) decreases act(p(HGNC:SNCA))
pmid:14556719 p(HGNC:PRKN) regulates p(HGNC:SNCA)
pmid:14556719 p(HGNC:PRKN) association p(HGNC:SNCA, pmod(OGlyco))
pmid:14556719 p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub))
pmid:14556719 p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub))
pmid:14556719 p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(Ub)), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies"))
pmid:14556719 p(HGNC:PRKN) increases act(complex(GO:"proteasome complex"))
pmid:14556719 p(HGNC:PRKN) decreases act(p(HGNC:CASP12))
pmid:14556719 p(HGNC:PRKN) association p(HGNC:CCNE1)
pmid:14556719 p(HGNC:PRKN) decreases p(HGNC:CCNE1)
pmid:14556719 p(HGNC:PRKN) decreases bp(GO:"neuron apoptotic process")
pmid:14556719 p(HGNC:PRKN) decreases bp(GO:"cell death")
pmid:14556719 p(HGNC:PRKN) increases p(HGNC:SYT11, pmod(Ub))
pmid:14556719 p(HGNC:PRKN) association a(GO:"actin filament")
pmid:14556719 p(HGNC:PRKN) regulates act(a(MESH:Actins))
pmid:14556719 p(HGNC:PRKN) association p(HGNC:SNCA, pmod(Glyco))
pmid:22908190 p(HGNC:PRKN) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:PRKN) increases bp(GO:mitophagy)
pmid:22908190 p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process")
pmid:23528736 p(HGNC:PRKN) association path(MESH:"Neurodegenerative Diseases")
pmid:14556719 p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinsonian Disorders")
pmid:14556719 p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN))
pmid:14556719 p(HGNC:PRKN, var("?")) increases p(HGNC:PRKN)
pmid:14556719 p(HGNC:PRKN, var("?")) decreases act(p(HGNC:SEPT5))
pmid:14556719 p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA))
pmid:28803412 p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases")
pmid:30116051 p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease")
pmid:30116051 p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy)
pmid:30116051 p(HGNC:PRKN, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:14556719 path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies")
pmid:14556719 path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies")
pmid:14556719 path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37)
pmid:14556719 path(MESH:"Parkinsonian Disorders") association p(HGNC:SNCA, var("?"))
pmid:14556719 path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies")
pmid:14556719 path(MESH:"Parkinsonian Disorders") association p(HGNC:PRKN, var("p.Lys161Asn"))
pmid:14556719 path(MESH:"Parkinsonian Disorders") positiveCorrelation a(HBP:"alpha-synuclein aggregates")
pmid:14556719 path(MESH:"Parkinsonian Disorders") increases path(HBP:Neurodegeneration)
pmid:14556719 path(MESH:"Parkinsonian Disorders") association g(HGNC:PARK7, var("?"))
pmid:14556719 path(MESH:"Parkinsonian Disorders") association p(HGNC:PARK7, var("p.Leu166Pro"))
pmid:30126037 path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive")
pmid:14556719 p(HGNC:PRKN, var("p.Arg42")) decreases complex(a(GO:"proteasome complex"), p(HGNC:PRKN))
pmid:14556719 p(HGNC:PRKN, var("p.Arg42")) increases path(MESH:"Parkinsonian Disorders")
pmid:14556719 complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) decreases path(MESH:"Parkinsonian Disorders")
pmid:14556719 complex(GO:"SCF ubiquitin ligase complex") increases p(HGNC:CCNE1, pmod(Ub))
pmid:29121589 p(HGNC:CUL1) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph)))
pmid:14556719 p(INTERPRO:"IBR domain", var("?")) decreases act(p(HGNC:PRKN))
pmid:14556719 complex(p(HGNC:PRKN), p(HGNC:STUB1)) increases act(p(HGNC:PRKN))
pmid:14556719 p(HGNC:SEPT5) decreases sec(a(CHEBI:"growth hormone"))
pmid:14556719 p(HGNC:SEPT5) regulates sec(a(CHEBI:neurotransmitter))
pmid:14556719 p(HGNC:SEPT5) regulates act(a(GO:"synaptic vesicle"))
pmid:14556719 complex(p(HGNC:SEPT5), p(HGNC:STX1A)) decreases bp(GO:exocytosis)
pmid:29191965 a(GO:"synaptic vesicle") association complex(p(HGNC:KLC3), p(HGNC:MAPT))
pmid:14556719 p(HGNC:GPR37) association p(HGNC:PRKN)
pmid:14556719 p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(HBP:misfolding))
pmid:14556719 p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death")
pmid:14556719 p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders")
pmid:14556719 bp(GO:"response to unfolded protein") increases bp(GO:"cell death")
pmid:14556719 bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress")
pmid:14556719 bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones")
pmid:14556719 bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration")
pmid:23746257 bp(GO:"response to unfolded protein") regulates bp(HBP:Proteostasis)
pmid:24563850 bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:HSPA5))
pmid:24563850 bp(GO:"response to endoplasmic reticulum stress") decreases bp(HBP:misfolding)
pmid:24563850 bp(GO:"response to endoplasmic reticulum stress") decreases bp(GO:"cell death")
pmid:24563850 bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"cell death")
pmid:24563850 bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"apoptotic process")
pmid:23702978 bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:14556719 p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein")
pmid:14556719 composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37))
pmid:14556719 a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein")
pmid:14556719 bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein")
pmid:14556719 bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein")
pmid:14556719 bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein")
pmid:23746257 bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins")
pmid:23746257 bp(MESH:"Heat-Shock Response") association p(FPLX:HSP90)
pmid:23746257 bp(MESH:"Heat-Shock Response") regulates bp(HBP:Proteostasis)
pmid:29807032 bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621))
pmid:29807032 bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621))
pmid:29807032 bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507)
pmid:29807032 bp(MESH:"Heat-Shock Response") causesNoChange p(NCBIGENE:492507)
pmid:29807032 bp(MESH:"Heat-Shock Response") increases p(MESH:"corticotropin releasing factor-binding protein")
pmid:29807032 bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures")
pmid:29807032 bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures")
pmid:29807032 bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures")
pmid:14556719 p(HGNC:SNCA, pmod(OGlyco)) association p(HGNC:PRKN)
pmid:14556719 p(HGNC:SNCAIP) association p(HGNC:SNCA)
pmid:14556719 composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies")
pmid:14556719 p(HGNC:ATXN3, frag("?")) decreases act(complex(GO:"proteasome complex"))
pmid:14556719 p(HGNC:ATXN3, frag("?")) increases act(p(HGNC:CASP12))
pmid:14556719 p(HGNC:CCNE1) association p(HGNC:PRKN)
pmid:14556719 p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process")
pmid:14556719 composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1)
pmid:14556719 p(HGNC:AIMP2) increases bp(GO:"cell death")
pmid:14556719 p(HGNC:PRKN, var("p.Lys161Asn")) association path(MESH:"Parkinsonian Disorders")
pmid:14556719 p(HGNC:PRKN, var("p.Lys161Asn")) increases p(HGNC:AIMP2, pmod(Ub))
pmid:14556719 p(HGNC:SYT11, pmod(Ub)) association bp(GO:"synaptic vesicle transport")
pmid:14556719 p(HGNC:SYT11, pmod(Ub)) association sec(a(CHEBI:neurotransmitter))
pmid:14556719 bp(GO:"synaptic vesicle transport") association p(HGNC:SYT11, pmod(Ub))
pmid:14556719 a(GO:"actin filament") association p(HGNC:PRKN)
pmid:14556719 p(HGNC:UBE3A) increases complex(a(HBP:"protein aggregates"), a(MESH:Neurons))
pmid:14556719 act(p(HGNC:UBE3A)) decreases bp(GO:"cell death")
pmid:22908190 p(HGNC:UBE3A) increases deg(p(HGNC:ARC))
pmid:14556719 p(HGNC:UCHL1, var("?")) association path(MESH:"Parkinson Disease")
pmid:14556719 p(HGNC:UCHL1, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:23528736 p(HGNC:UCHL1, var("?")) association path(MESH:"Neurodegenerative Diseases")
pmid:23528736 p(HGNC:UCHL1, var("?")) association path(MESH:"Alzheimer Disease")
pmid:14556719 p(HGNC:UCHL1, var("p.Ile93Met")) association path(MESH:"Parkinson Disease")
pmid:14556719 complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination")
pmid:22908190 p(HGNC:SNCA, pmod(Ub)) positiveCorrelation p(HGNC:SNCA)
pmid:22908190 p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:"Parkinson Disease")
pmid:22908190 p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:Dementia)
pmid:14556719 p(HGNC:UCHL3) decreases path(MESH:"Deglutition Disorders")
pmid:14556719 p(HGNC:UCHL3) positiveCorrelation a(MESH:"Solitary Nucleus")
pmid:14556719 p(HGNC:UCHL3) positiveCorrelation a(MESH:"Area Postrema")
pmid:14556719 a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL1)
pmid:14556719 a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL3)
pmid:14556719 a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL1)
pmid:14556719 a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL3)
pmid:14556719 bp(HBP:"Alpha-synuclein Oligomerization") positiveCorrelation p(HGNC:SNCA)
pmid:14556719 bp(HBP:"Alpha-synuclein Oligomerization") increases a(HBP:"alpha-synuclein fibrils")
pmid:14556719 a(HBP:"alpha-synuclein fibrils") increases a(HBP:"alpha-synuclein aggregates")
pmid:14556719 p(HGNC:SNCA, pmod(Glyco)) association p(HGNC:PRKN)
pmid:14556719 complex(a(HBP:"alpha-synuclein aggregates"), p(HGNC:PSMC4)) decreases act(complex(GO:"proteasome complex"))
pmid:14556719 complex(p(HGNC:PSMC4), p(HGNC:SNCA)) decreases act(complex(GO:"proteasome complex"))
pmid:29191965 p(HGNC:TH) regulates a(CHEBI:dopamine)
pmid:29191965 p(HGNC:TH) regulates a(CHEBI:serotonin)
pmid:29191965 p(HGNC:TH) regulates act(p(HGNC:DDC))
pmid:14556719 g(HGNC:PARK7, var("?")) association path(MESH:"Parkinsonian Disorders")
pmid:14556719 p(HGNC:PARK7, pmod(Sumo)) regulates act(p(HGNC:PARK7))
pmid:14556719 complex(p(HGNC:PARK7), p(HGNC:PIAS2)) increases p(HGNC:PARK7, pmod(Sumo))
pmid:14556719 p(HGNC:PARK7, var("p.Leu166Pro")) association path(MESH:"Parkinsonian Disorders")
pmid:14556719 p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7))
pmid:14556719 p(HGNC:CFTR, var("p.Phe508del")) increases deg(p(HGNC:CFTR))
pmid:14556719 p(HGNC:CFTR, var("p.Phe508del")) increases path(MESH:"Cystic Fibrosis")
pmid:29311797 path(MESH:"Cystic Fibrosis") association p(HGNC:STUB1)
pmid:29311797 path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1)
pmid:14556719 bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR))
pmid:14556719 bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(HBP:misfolding)))
pmid:24457024 bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding)))
pmid:14556719 p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(HBP:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol))
pmid:14556719 g(HGNC:MAPT, var("?")) increases path(MESH:"Pick Disease of the Brain")
pmid:27574109 path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"3R tau")
pmid:27574109 path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"4R tau")
pmid:27574109 path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT)
pmid:27574109 path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT)
pmid:27574109 path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers")
pmid:27574109 path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers")
pmid:27574109 path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT))
pmid:29311797 path(MESH:"Pick Disease of the Brain") isA path(MESH:Tauopathies)
pmid:26195256 path(MESH:"Pick Disease of the Brain") association path(MESH:"Alzheimer Disease")
pmid:27260836 path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body")
pmid:22057784 path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
pmid:22057784 path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:22057784 path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(NO, Tyr, 29))
pmid:14556719 composite(a(CHEBI:"amyloid-beta"), p(HGNC:MAPT, var("?"))) increases path(MESH:"Alzheimer Disease")
pmid:14556719 a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex"))
pmid:14556719 a(CHEBI:lactacystin) increases bp(GO:"cell death")
pmid:22908190 a(CHEBI:lactacystin) decreases bp(GO:"long-term memory")
pmid:30145931 a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome))
pmid:23528736 a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome))
pmid:24027553 a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT))
pmid:24027553 a(CHEBI:lactacystin) increases p(HGNC:MAPT)
pmid:23528736 a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT))
pmid:24027553 a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.P301L"))
pmid:24027553 a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome))
pmid:14556719 a(MESH:Prions) increases path(MESH:"Prion Diseases")
pmid:14556719 a(MESH:Prions) increases path(MESH:"Encephalopathy, Bovine Spongiform")
pmid:14556719 path(MESH:"Prion Diseases") increases path(MESH:"Motor Disorders")
pmid:14556719 path(MESH:"Prion Diseases") increases path(MESH:Dementia)
pmid:14556719 path(MESH:"Prion Diseases") increases path(MESH:Death)
pmid:14556719 path(MESH:"Prion Diseases") increases bp(GO:"neuron death")
pmid:14556719 path(MESH:"Prion Diseases") increases path(MESH:Gliosis)
pmid:14556719 path(MESH:"Prion Diseases") increases a(HBP:"amyloid-beta aggregates")
pmid:14556719 path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:14556719 path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:14556719 complex(p(HGNC:HSPA5), p(HGNC:PRNP)) increases bp(GO:"protein folding")
pmid:14556719 p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:14556719 p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress")
pmid:14556719 p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress")
pmid:14556719 p(HGNC:SOD1, var("?")) increases bp(GO:"cell death")
pmid:14556719 p(HGNC:SOD1, var("?")) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:14556719 p(HGNC:SOD1, var("?")) increases act(complex(GO:"proteasome complex"))
pmid:18930136 p(HGNC:SOD1, var("?")) association p(HGNC:SQSTM1)
pmid:14556719 p(HGNC:SOD1, pmod(HBP:misfolding)) increases a(HBP:"protein aggregates")
pmid:14556719 p(HGNC:RNF19A) decreases bp(GO:"cell death")
pmid:14556719 p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:14556719 p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?")))
pmid:14556719 p(HGNC:UBL5) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:14556719 composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) increases bp(GO:"cell death")
pmid:14556719 p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease")
pmid:14556719 p(HGNC:HTT, var("?")) increases a(HBP:"huntingtin aggregates")
pmid:14556719 p(HGNC:HTT, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:14556719 p(HGNC:HTT, var("?")) decreases act(p(HBP:"20 S Proteasome"))
pmid:14556719 p(HGNC:HTT, var("?")) decreases deg(p(HGNC:TP53))
pmid:14556719 p(HGNC:HTT, var("?")) decreases bp(MESH:"Membrane Potential, Mitochondrial")
pmid:14556719 p(HGNC:HTT, var("?")) increases sec(a(CHEBI:"cytochrome c"))
pmid:14556719 p(HGNC:HTT, var("?")) increases act(p(FPLX:Caspase))
pmid:14556719 p(HGNC:HTT, var("?")) increases bp(GO:"apoptotic process")
pmid:25784053 p(HGNC:HTT, var("?")) increases p(FPLX:HSPA)
pmid:30116051 p(HGNC:HTT, var("?")) decreases bp(GO:autophagy)
pmid:30116051 p(HGNC:HTT, var("?")) decreases bp(GO:"cargo loading into vesicle")
pmid:30116051 p(HGNC:HTT, var("?")) decreases bp(GO:"autophagosome assembly")
pmid:14556719 p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2))
pmid:14556719 p(HGNC:HTT) decreases act(complex(GO:"proteasome complex"))
pmid:14556719 p(HGNC:HTT) increases bp(GO:"cell cycle arrest")
pmid:14556719 p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies")
pmid:26631930 p(HGNC:CREBBP) increases p(HGNC:MAPT, pmod(Ac, Lys))
pmid:14556719 p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies")
pmid:14556719 p(HGNC:CDC34, var("?")) increases bp(GO:"cell death")
pmid:24457024 p(HGNC:CDC34) increases complex(a(MESH:Ubiquitin), p(HGNC:CDC34))
pmid:14556719 p(HGNC:RAD23A) increases tloc(p(HGNC:ATXN3, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex"))
pmid:14556719 composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases a(HBP:"protein aggregates")
pmid:14556719 composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases bp(GO:"cell death")
pmid:14556719 composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases a(HBP:"protein aggregates")
pmid:14556719 composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases bp(GO:"cell death")
pmid:14556719 a(CHEBI:"Congo Red") decreases a(HBP:"huntingtin aggregates")
pmid:14556719 a(CHEBI:"Congo Red") increases act(complex(GO:"proteasome complex"))
pmid:22908190 p(FPLX:Caspase) increases deg(p(HGNC:MAPT))
pmid:29626319 p(FPLX:Caspase) increases deg(p(HGNC:MAPT))
pmid:25374103 p(FPLX:Caspase) positiveCorrelation path(MESH:Tauopathies)
pmid:25374103 act(p(FPLX:Caspase)) negativeCorrelation p(HGNC:STUB1)
pmid:26631930 p(FPLX:Caspase) increases p(HGNC:MAPT, frag("26_230"))
pmid:22908190 bp(GO:"proteasomal protein catabolic process") negativeCorrelation bp(GO:autophagy)
pmid:22908190 bp(GO:"proteasomal protein catabolic process") decreases a(MESH:Proteins)
pmid:22908190 bp(GO:"proteasomal protein catabolic process") association p(HGNC:SQSTM1)
pmid:24027553 bp(GO:"proteasomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT))
pmid:29626319 bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT))
pmid:26631930 bp(GO:"proteasomal protein catabolic process") decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)))
pmid:26631930 bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(Ub)))
pmid:26631930 bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(UbK63)))
pmid:22908190 composite(a(MESH:Ubiquitin), p(HGNC:SQSTM1)) increases act(p(HGNC:VCP))
pmid:22908190 act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway")
pmid:22908190 act(p(HGNC:VCP)) regulates a(GO:autophagosome)
pmid:24457024 p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process")
pmid:24457024 p(HGNC:VCP) increases bp(GO:"protein ubiquitination")
pmid:22908190 path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin)
pmid:22908190 path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin)
pmid:22908190 a(MESH:"Neuropil Threads") association a(MESH:Ubiquitin)
pmid:22817713 a(MESH:"Neuropil Threads") association path(MESH:"Alzheimer Disease")
pmid:18239272 a(MESH:"Neuropil Threads") association p(HBP:"Tau epitope, AT8")
pmid:22908190 bp(GO:"histone H2B ubiquitination") association bp(MESH:"Transcription, Genetic")
pmid:22908190 bp(MESH:"Transcription, Genetic") association bp(GO:"histone H2B ubiquitination")
pmid:22908190 p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) association a(HBP:"paired helical filaments")
pmid:22908190 p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) association a(HBP:"paired helical filaments")
pmid:22908190 p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) association a(HBP:"paired helical filaments")
pmid:22908190 p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) association a(HBP:"paired helical filaments")
pmid:22908190 p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments")
pmid:22908190 p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments")
pmid:22908190 p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) association a(HBP:"paired helical filaments")
pmid:22908190 p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) association a(HBP:"paired helical filaments")
pmid:26751493 p(HBP:"Tau aggregates") association a(CHEBI:heparin)
pmid:26751493 p(HBP:"Tau aggregates") increases complex(a(CHEBI:heparin), p(HBP:"Tau aggregates"))
pmid:26751493 p(HBP:"Tau aggregates") partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates"))
pmid:26751493 p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 274))
pmid:19517062 p(HBP:"Tau aggregates") increases bp(GO:"apoptotic process")
pmid:19517062 p(HBP:"Tau aggregates") increases bp(GO:"necrotic cell death")
pmid:28760828 p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324))
pmid:28500862 p(HBP:"Tau aggregates") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:22908190 a(GO:"Lewy body") association a(MESH:Ubiquitin)
pmid:22908190 a(GO:"Lewy body") association a(MESH:Ubiquitin)
pmid:22908190 a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia)
pmid:22908190 a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia)
pmid:22908190 a(GO:"Lewy body") association p(HGNC:MAPT)
pmid:18930136 a(GO:"Lewy body") association p(HGNC:SQSTM1)
pmid:22908190 a(GO:"Pick body") association p(HGNC:MAPT)
pmid:27574109 a(GO:"Pick body") association p(HGNC:MAPT)
pmid:22908190 a(GO:"Pick body") association a(MESH:Ubiquitin)
pmid:27574109 a(GO:"Pick body") association a(HBP:"Tau oligomers")
pmid:27574109 a(GO:"Pick body") association a(HBP:"phosphatase-activating domain")
pmid:22908190 p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:22908190 p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:22908190 p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Frontotemporal Lobar Degeneration")
pmid:22908190 path(MESH:"Frontotemporal Lobar Degeneration") positiveCorrelation p(HGNC:TARDBP, pmod(Ub))
pmid:26631930 path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:FUS)
pmid:22908190 complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases p(MESH:Proteins, pmod(Ub))
pmid:24457024 complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination")
pmid:22908190 p(HGNC:UBE4A) increases bp(GO:"protein polyubiquitination")
pmid:22908190 complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) increases tloc(a(MESH:Proteins), fromLoc(GO:"proteasome regulatory particle"), toLoc(HBP:"20 S Proteasome"))
pmid:22908190 complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:22908190 complex(a(GO:"proteasome regulatory particle"), a(HBP:"paired helical filaments")) decreases act(complex(GO:"proteasome complex"))
pmid:22908190 p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation)) increases p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation), pmod(Ub))
pmid:22908190 p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23528736 p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 p(HBP:"UBB+1") positiveCorrelation path(MESH:"Niemann-Pick Diseases")
pmid:22908190 p(HBP:"UBB+1") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:22908190 p(HBP:"UBB+1") decreases bp(GO:memory)
pmid:23528736 p(HBP:"UBB+1") association a(MESH:"Neurofibrillary Tangles")
pmid:23528736 p(HBP:"UBB+1") decreases bp(GO:"protein deubiquitination")
pmid:23528736 p(HBP:"UBB+1") decreases act(p(FPLX:Proteasome))
pmid:23528736 p(HBP:"UBB+1") increases bp(HP:Neurodegeneration)
pmid:23528736 p(HBP:"UBB+1") increases bp(MESH:"Stress, Physiological")
pmid:23528736 p(HBP:"UBB+1") increases act(p(HGNC:TP53))
pmid:22908190 p(HBP:"UBB+1", pmod(UbPoly)) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:22908190 p(HBP:"UBB+1", pmod(UbPoly)) decreases deg(p(HBP:"UBB+1", pmod(UbPoly)))
pmid:22908190 p(HGNC:UCHL1, pmod(GO:"protein oxidation")) negativeCorrelation a(GO:"neurofibrillary tangle")
pmid:22908190 p(HGNC:UBQLN1) association path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:UBQLN1) increases complex(a(GO:"proteasome complex"), p(HGNC:UBQLN1))
pmid:22908190 p(HGNC:UBQLN1) increases complex(p(HGNC:UBQLN1), p(MESH:Proteins, pmod(Ub)))
pmid:22908190 p(HGNC:UBQLN1) regulates deg(p(HGNC:PSEN1))
pmid:22908190 p(HGNC:UBQLN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 deg(p(FPLX:PKA, pmod(Ub))) increases act(p(FPLX:PKA))
pmid:22908190 p(HGNC:ARC) regulates bp(GO:"synapse maturation")
pmid:22908190 act(a(MESH:Neurites)) negativeCorrelation p(HGNC:APP, var("?"))
pmid:22908190 complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:22908190 complex(GO:"clathrin complex") increases bp(GO:"plasma membrane invagination")
pmid:22908190 a(GO:caveola) increases bp(GO:"plasma membrane invagination")
pmid:22908190 bp(GO:"bulk synaptic vesicle endocytosis") increases bp(GO:"plasma membrane invagination")
pmid:29590627 bp(GO:"bulk synaptic vesicle endocytosis") negativeCorrelation a(CHEBI:"cytochalasin D")
pmid:29590627 bp(GO:"bulk synaptic vesicle endocytosis") positiveCorrelation bp(GO:"actin filament polymerization")
pmid:22908190 p(HGNC:RAB7A) increases a(GO:endosome)
pmid:22908190 p(HGNC:RAB7A) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:RAB7A) increases complex(a(GO:"early endosome"), a(GO:"late endosome"))
pmid:22908190 p(HGNC:RAB7A) association bp(GO:"regulation of endosome size")
pmid:18930136 p(HGNC:RAB7A) increases bp(GO:"autophagosome-lysosome fusion")
pmid:29238289 p(HGNC:RAB7A) association p(HGNC:MAPT)
pmid:22908190 act(a(GO:endosome)) increases bp(GO:"nerve growth factor signaling pathway")
pmid:22908190 act(a(GO:endosome)) decreases path(HBP:Neurodegeneration)
pmid:22908190 complex(GO:"ESCRT complex") regulates tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body"))
pmid:22908190 p(HGNC:M6PR) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body"))
pmid:22908190 a(MESH:Cathepsins) regulates deg(a(CHEBI:"amyloid-beta"))
pmid:22908190 sec(a(MESH:Cathepsins)) increases bp(GO:"apoptotic process")
pmid:22908190 p(HGNC:IGF2R) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body"))
pmid:22908190 bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome))
pmid:22908190 bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:"multivesicular body"))
pmid:18930136 bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome))
pmid:29626319 bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process")
pmid:29626319 bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 bp(GO:"lysosomal microautophagy") decreases a(HBP:"Tau aggregates")
pmid:29626319 bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?"))
pmid:22908190 complex(a(GO:"late endosome"), a(GO:autophagosome), a(GO:lysosome)) increases deg(a(MESH:Proteins))
pmid:29024336 a(GO:"late endosome") increases deg(p(MGI:Mapt))
pmid:29024336 a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu")))
pmid:29024336 a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr")))
pmid:29590627 a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser"))
pmid:29590627 a(GO:"late endosome") association a(HBP:"Tau aggregates")
pmid:22908190 complex(a(GO:"early endosome"), a(GO:autophagosome)) increases a(GO:amphisome)
pmid:29590627 a(GO:"early endosome") association p(HGNC:MAPT, var("p.Pro301Ser"))
pmid:29590627 a(GO:"early endosome") association a(HBP:"Tau aggregates")
pmid:18930136 a(GO:amphisome) increases complex(a(GO:amphisome), a(GO:lysosome))
pmid:22908190 bp(GO:"response to nutrient") regulates p(HGNC:MTOR)
pmid:22908190 bp(GO:"regulation of endosome size") association path(MESH:"Neurodegenerative Diseases")
pmid:22908190 bp(GO:"regulation of endosome size") association a(HBP:"Braak_Stage II")
pmid:22908190 bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome")
pmid:22908190 bp(GO:"regulation of endosome size") association p(HGNC:RAB7A)
pmid:22908190 bp(GO:"regulation of endosome size") association p(HGNC:RAB5A)
pmid:22908190 bp(GO:"regulation of endosome size") association p(HGNC:RAB4A)
pmid:22908190 a(HBP:"Braak_Stage II") association bp(GO:"regulation of endosome size")
pmid:27574109 a(HBP:"Braak_Stage II") association a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Braak_Stage II") association a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Braak_Stage II") association p(HGNC:MAPT)
pmid:28176663 a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin))
pmid:22908190 p(HGNC:RAB5A) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:RAB5A) increases complex(a(GO:"early endosome"), a(GO:"late endosome"))
pmid:22908190 p(HGNC:RAB5A) association bp(GO:"regulation of endosome size")
pmid:22908190 act(p(HGNC:RAB5A)) positiveCorrelation a(MESH:Proteins)
pmid:22908190 act(p(HGNC:RAB5A)) positiveCorrelation a(CHEBI:lipid)
pmid:22908190 act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"lysosomal protein catabolic process")
pmid:22908190 act(p(HGNC:RAB5A)) positiveCorrelation bp(GO:"neuron death")
pmid:22908190 act(p(HGNC:RAB5A)) increases bp(GO:endocytosis)
pmid:22908190 act(p(HGNC:RAB5A)) increases bp(GO:endocytosis)
pmid:22908190 act(p(HGNC:RAB5A)) decreases bp(GO:endocytosis)
pmid:22908190 act(p(HGNC:RAB5A)) increases a(CHEBI:"amyloid-beta")
pmid:22908190 act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic potentiation")
pmid:22908190 act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression")
pmid:30116051 act(p(HGNC:RAB5A)) decreases bp(HP:Neurodegeneration)
pmid:27607061 act(p(HGNC:RAB5A)) negativeCorrelation surf(p(HGNC:GRIK2))
pmid:27607061 act(p(HGNC:RAB5A)) partOf bp(GO:"clathrin-dependent endocytosis")
pmid:22908190 p(HGNC:RAB4A) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22908190 p(HGNC:RAB4A) increases complex(a(GO:"early endosome"), a(GO:"late endosome"))
pmid:22908190 p(HGNC:RAB4A) association bp(GO:"regulation of endosome size")
pmid:22908190 p(HGNC:ATP6V0A1, pmod(NGlyco)) increases bp(GO:"pH reduction")
pmid:22908190 complex(a(GO:endosome), p(HGNC:APP, var("?")), p(HGNC:NAE1)) increases act(p(HGNC:RAB5A))
pmid:22908190 a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
pmid:22908190 a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
pmid:22908190 a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome))
pmid:22908190 bp(GO:"response to acidic pH") increases a(HBP:"amyloid-beta oligomers")
pmid:30116051 p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy")
pmid:26631930 p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, frag("?")) increases path(HBP:Neurodegeneration)
pmid:29626319 p(HGNC:MAPT, frag("?")) increases bp(HBP:neurotoxicity)
pmid:22908190 p(HGNC:RIN1) increases act(p(HGNC:RAB5A))
pmid:22908190 p(HGNC:RIN1) decreases bp(GO:"long-term synaptic potentiation")
pmid:22908190 p(HGNC:RIN1) decreases bp(GO:"fear response")
pmid:22908190 p(HGNC:RIN1) decreases bp(GO:memory)
pmid:22908190 p(HGNC:RIN1) decreases a(MESH:"Receptors, AMPA")
pmid:22908190 sec(a(MESH:Hydrolases)) increases path(MESH:Necrosis)
pmid:22908190 p(HGNC:CST3) decreases act(a(GO:synapse))
pmid:24563850 a(MESH:"Heat-Shock Proteins") regulates bp(GO:"response to oxidative stress")
pmid:21882945 a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process")
pmid:21882945 a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy)
pmid:23746257 act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"'de novo' protein folding")
pmid:23746257 act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"protein refolding")
pmid:23746257 bp(GO:"protein refolding") association act(p(HGNCGENEFAMILY:Chaperonins))
pmid:23746257 bp(GO:"protein refolding") association act(p(FPLX:HSPA))
pmid:23746257 bp(GO:"protein refolding") association act(p(FPLX:HSPA))
pmid:23746257 bp(GO:"protein refolding") association act(p(FPLX:HSP90))
pmid:23746257 complex(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) increases bp(GO:"'de novo' protein folding")
pmid:23746257 bp(GO:"steroid hormone mediated signaling pathway") association p(FPLX:HSP90)
pmid:23746257 bp(GO:"protein secretion") association p(FPLX:HSP90)
pmid:23746257 bp(GO:"intracellular protein transmembrane transport") association act(p(FPLX:HSPA))
pmid:23746257 p(FPLX:RAPGEF) regulates act(p(FPLX:HSPA))
pmid:23746257 composite(p(FPLX:HSPA), p(HGNC:HSPH1), p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")) decreases a(MESH:"Protein Aggregates")
pmid:21882945 p(HGNC:HSPH1) decreases p(HGNC:MAPT, pmod(Ph))
pmid:23746257 complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) increases bp(GO:"protein refolding")
pmid:23746257 complex(a(CHEBI:ATP), p(HGNC:HSPD1)) increases complex(p(HGNC:HSPD1), p(HGNC:HSPE1))
pmid:23746257 complex(a(CHEBI:ATP), p(FPLX:HSP90)) regulates act(p(FPLX:HSP90))
pmid:23746257 bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90))
pmid:25784053 bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90))
pmid:29311797 bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90))
pmid:25784053 bp(GO:"ATP metabolic process") increases act(p(FPLX:HSPA))
pmid:23746257 p(HGNC:CDC37) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity"))
pmid:21882945 p(HGNC:CDC37) regulates act(p(FPLX:HSP90))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation act(p(FPLX:HSP90))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AHSA1), p(HGNC:CDC37))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:CDC37))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK11A))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK1))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKG))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK4))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:FER))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CHUK))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:RAF1))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:CDC37))
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37))
pmid:25036637 p(HGNC:CDC37) association p(HGNC:FKBP5)
pmid:25036637 p(HGNC:CDC37) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:CDC37))
pmid:21882945 p(HGNC:CDC37) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90))
pmid:29311797 p(HGNC:CDC37) increases p(HGNC:MAPT)
pmid:21367866 p(HGNC:CDC37) decreases deg(p(HGNC:MAPT))
pmid:21367866 p(HGNC:CDC37) isA complex(p(FPLX:HSP90), p(HGNC:CDC37))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:21367866 p(HGNC:CDC37) positiveCorrelation act(p(HGNC:CDK5))
pmid:21367866 p(HGNC:CDC37) causesNoChange p(HGNC:GSK3B)
pmid:21367866 p(HGNC:CDC37) causesNoChange p(HGNC:MARK2)
pmid:23746257 p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity"))
pmid:21882945 p(HGNC:AHSA1) regulates act(p(FPLX:HSP90))
pmid:29311797 p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity"))
pmid:21882945 p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP)))
pmid:21882945 p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1))
pmid:29311797 p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29311797 p(HGNC:AHSA1) increases a(HBP:"Tau oligomers")
pmid:29311797 p(HGNC:AHSA1) increases bp(GO:"neuron apoptotic process")
pmid:29311797 p(HGNC:AHSA1) increases a(HBP:"Tau aggregates")
pmid:29311797 p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis")
pmid:23746257 bp(GO:"behavioral response to starvation") association bp(HBP:Proteostasis)
pmid:23746257 p(FPLX:Proteasome) increases bp(GO:"protein catabolic process")
pmid:23746257 p(FPLX:Proteasome) increases bp(GO:"protein unfolding")
pmid:25784053 p(FPLX:Proteasome) increases bp(MESH:Proteolysis)
pmid:25784053 p(FPLX:Proteasome) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:25784053 act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:30145931 act(p(FPLX:Proteasome)) decreases path(HBP:neurotoxicity)
pmid:30145931 act(p(FPLX:Proteasome)) decreases p(HGNC:MAPT)
pmid:30145931 act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262)))
pmid:30145931 act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 356)))
pmid:23746257 composite(p(FPLX:HSP90), p(FPLX:HSPA), p(HGNC:BAG1), p(HGNC:BAG3), p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination")
pmid:23746257 p(HGNC:BAG1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:25036637 p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1))
pmid:25036637 p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5))
pmid:25036637 p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4))
pmid:25036637 p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2))
pmid:21882945 p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21882945 p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT))
pmid:21882945 p(HGNC:BAG1) decreases deg(p(HGNC:MAPT))
pmid:17954934 p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT)
pmid:17954934 p(HGNC:BAG1) decreases deg(p(HGNC:MAPT))
pmid:17954934 p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1))
pmid:17954934 p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:17954934 p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:23746257 a(CHEBI:Guanabenz) decreases act(p(FPLX:ADRA2))
pmid:23746257 a(CHEBI:Guanabenz) decreases act(p(FPLX:EIF2B))
pmid:23746257 a(CHEBI:Guanabenz) increases p(FPLX:EIF2B, pmod(Ph))
pmid:23746257 p(FPLX:EIF2B, pmod(Ph)) decreases act(p(FPLX:EIF2B))
pmid:23746257 a(CHEBI:geldanamycin) increases act(p(HGNC:HSF1))
pmid:25784053 a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90))
pmid:30116051 a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90))
pmid:21882945 a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90))
pmid:21882945 a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90))
pmid:30116051 a(CHEBI:geldanamycin) decreases p(HGNC:MAPT, pmod(HBP:HBP00007))
pmid:30116051 a(CHEBI:geldanamycin) decreases a(HBP:HBP00016)
pmid:24027553 a(CHEBI:geldanamycin) increases act(p(HGNCGENEFAMILY:Proteasome))
pmid:21882945 a(CHEBI:geldanamycin) decreases complex(p(FPLX:HSP90), p(HGNC:PTGES3))
pmid:23746257 composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(MESH:"Protein Aggregates")
pmid:23746257 composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(HBP:"huntingtin aggregates")
pmid:24457024 complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin))
pmid:24457024 complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin))
pmid:24457024 p(HGNC:UBE2K) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2K))
pmid:24457024 p(HGNC:UBE2S) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2S))
pmid:24457024 path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2))
pmid:24457024 p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2))
pmid:24457024 complex(a(MESH:Ubiquitin), p(MESH:Proteins, pmod(HBP:misfolding))) increases deg(p(MESH:Proteins, pmod(HBP:misfolding)))
pmid:24457024 p(HGNC:BAG6) increases complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding)))
pmid:24457024 complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) association bp(GO:"ERAD pathway")
pmid:24457024 complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding)))
pmid:24457024 complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination")
pmid:24457024 complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(HBP:"protein aggregation")
pmid:24457024 complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding)))
pmid:24457024 complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(HBP:"protein aggregation")
pmid:24457024 complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases bp(GO:"protein ubiquitination")
pmid:24457024 a(MESH:"Deubiquitinating Enzymes") decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin))
pmid:24457024 complex(a(GO:"proteasome complex"), p(HGNC:UCHL5)) increases bp(GO:"protein catabolic process")
pmid:24457024 complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process")
pmid:24457024 complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process")
pmid:25784053 p(HGNC:USP14) decreases deg(p(HGNC:MAPT))
pmid:25784053 p(HGNC:USP14) decreases deg(p(HGNC:TARDBP))
pmid:25784053 p(HGNC:USP14) decreases act(p(FPLX:Proteasome))
pmid:26041011 act(p(HGNC:USP14)) decreases act(complex(GO:"proteasome complex"))
pmid:24457024 act(p(HGNC:USP6)) decreases path(MESH:Aneuploidy)
pmid:24457024 p(HGNC:ADRM1) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub)))
pmid:25036637 p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMA5))
pmid:25036637 p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1))
pmid:25036637 p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD1))
pmid:25036637 p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD4))
pmid:24457024 p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin))
pmid:24457024 p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin))
pmid:24457024 act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome"))
pmid:24457024 complex(a(GO:"proteasome complex"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome"))
pmid:25784053 bp(MESH:"Protein Biosynthesis") association bp(HBP:Proteostasis)
pmid:25784053 bp(MESH:Proteolysis) association bp(HBP:Proteostasis)
pmid:29311797 bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones")
pmid:25784053 bp(MESH:"Growth and Development") regulates bp(HBP:Proteostasis)
pmid:25784053 complex(p(FPLX:HSPA), p(HGNC:DNAJB1), p(HGNC:HSPH1)) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:25784053 p(HGNC:DNAJB1) negativeCorrelation path(MESH:"Protein Aggregation, Pathological")
pmid:25036637 p(HGNC:DNAJB1) increases complex(p(HGNC:DNAJB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25784053 a(MESH:"Cellular Structures") association p(FPLX:"CCT_complex")
pmid:25784053 bp(GO:"intracellular transport") association p(FPLX:"CCT_complex")
pmid:25784053 a(MESH:Lysosomes) increases bp(MESH:Proteolysis)
pmid:25784053 a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:24027553 a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29238289 act(a(MESH:Lysosomes)) decreases p(HGNC:MAPT)
pmid:25784053 bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1))
pmid:25784053 bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(kin))
pmid:25784053 p(HGNC:HSF1, pmod(Ac)) decreases act(p(HGNC:HSF1))
pmid:25784053 complex(a(MESH:"Molecular Chaperones"), p(HGNC:HSF1)) decreases act(p(HGNC:HSF1))
pmid:25784053 act(p(HGNC:ERN1), ma(kin)) increases p(HGNC:ERN1, pmod(Ph))
pmid:25784053 act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1)
pmid:25784053 p(HGNC:ERN1, pmod(Ph)) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity"))
pmid:25784053 act(p(HGNC:XBP1), ma(tscript)) increases bp(GO:"response to misfolded protein")
pmid:25784053 bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus"))
pmid:25784053 bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:EIF2AK3), ma(kin))
pmid:25784053 p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:25784053 p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease")
pmid:25784053 p(HGNC:PRSS1) decreases p(HGNC:ATF6)
pmid:25784053 p(HGNC:PRSS1) increases p(HBP:"N-terminal fragment of ATF6")
pmid:25784053 p(HGNC:PRSS2) decreases p(HGNC:ATF6)
pmid:25784053 p(HGNC:PRSS2) increases p(HBP:"N-terminal fragment of ATF6")
pmid:25784053 tloc(p(HBP:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript))
pmid:25784053 act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) increases bp(GO:"response to misfolded protein")
pmid:25784053 act(p(HGNC:EIF2AK3), ma(kin)) increases p(HGNC:EIF2S1, pmod(Ph))
pmid:25784053 p(HGNC:EIF2S1, pmod(Ph)) increases act(p(HGNC:EIF2S1), ma(tscript))
pmid:23702978 p(HGNC:EIF2S1, pmod(Ph)) decreases bp(GO:translation)
pmid:25784053 act(p(HGNC:EIF2S1), ma(tscript)) increases p(HGNC:ATF4)
pmid:25784053 p(HGNC:ATF4) increases p(HGNC:DDIT3)
pmid:25784053 p(HGNC:DDIT3) increases bp(GO:"apoptotic process")
pmid:23702978 p(HGNC:DDIT3) regulates a(CHEBI:"calcium(2+)")
pmid:23702978 p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:25784053 p(HGNC:ATXN1, var("?")) causesNoChange p(FPLX:HSPA)
pmid:25784053 p(MGI:Atg5) decreases bp(HP:Neurodegeneration)
pmid:25784053 p(MGI:Atg7) decreases bp(HP:Neurodegeneration)
pmid:24027553 p(MGI:Atg7) decreases path(HBP:Neurodegeneration)
pmid:24027553 p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph))
pmid:24027553 p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))
pmid:24027553 p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:24027553 p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Thr, 231))
pmid:25784053 p(HGNC:RAB1A) increases bp(GO:"autophagosome assembly")
pmid:29238289 p(HGNC:RAB1A) association p(HGNC:MAPT)
pmid:25784053 p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:"N-retinylidene-N-retinylethanolamine")
pmid:25784053 p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A)
pmid:25784053 p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1)
pmid:25784053 p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy)
pmid:24027553 p(HGNC:MAP1LC3A) positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:25784053 a(CHEBI:chloroquine) decreases bp(GO:autophagy)
pmid:25784053 a(CHEBI:chloroquine) increases a(CHEBI:"N-retinylidene-N-retinylethanolamine")
pmid:25784053 a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A)
pmid:25784053 a(CHEBI:chloroquine) increases p(HGNC:SQSTM1)
pmid:24027553 a(CHEBI:chloroquine) increases p(HGNC:MAPT)
pmid:24027553 a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT))
pmid:25784053 a(CHEBI:radicicol) decreases act(p(FPLX:HSP90))
pmid:21882945 a(CHEBI:radicicol) directlyDecreases act(p(FPLX:HSP90))
pmid:21882945 a(CHEBI:radicicol) directlyIncreases complex(a(CHEBI:radicicol), p(INTERPRO:"Heat shock protein Hsp90, N-terminal"))
pmid:25784053 a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90))
pmid:30116051 a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90))
pmid:21882945 a(CHEBI:tanespimycin) directlyDecreases act(p(FPLX:HSP90))
pmid:21882945 a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90))
pmid:29311797 a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity"))
pmid:21367866 a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90))
pmid:30116051 a(CHEBI:tanespimycin) decreases a(CHEBI:"amyloid-beta")
pmid:30116051 a(CHEBI:tanespimycin) increases bp(GO:memory)
pmid:30116051 a(CHEBI:tanespimycin) decreases p(HGNC:MAPT)
pmid:30116051 a(CHEBI:tanespimycin) decreases a(HBP:HBP00016)
pmid:21882945 a(CHEBI:tanespimycin) directlyIncreases complex(a(CHEBI:tanespimycin), p(INTERPRO:"Heat shock protein Hsp90, N-terminal"))
pmid:21882945 a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
pmid:21882945 a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
pmid:29311797 a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph))
pmid:25784053 a(PUBCHEM:377503130) increases act(p(HGNC:HSF1))
pmid:25784053 a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex"))
pmid:30116051 p(FPLX:mTORC1) increases bp(GO:macroautophagy)
pmid:30116051 p(FPLX:mTORC1) decreases bp(GO:macroautophagy)
pmid:30116051 p(FPLX:mTORC1) decreases bp(GO:mitophagy)
pmid:30116051 p(FPLX:mTORC1) increases p(HGNC:ULK1, pmod(Ph, Ser, 757))
pmid:30116051 p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus"))
pmid:30116051 act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB))
pmid:30116051 act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2))
pmid:30116051 p(FPLX:mTORC1) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:30116051 p(FPLX:mTORC1) decreases bp(GO:"proteasome assembly")
pmid:23528736 p(FPLX:mTORC1) decreases bp(GO:autophagy)
pmid:23528736 act(p(FPLX:mTORC1), ma(kin)) increases p(HGNC:ULK1, pmod(Ph))
pmid:23528736 act(p(FPLX:mTORC1)) increases p(HGNC:MAPT)
pmid:30108137 p(FPLX:mTORC1) increases p(MGI:Tfeb, pmod(Ph))
pmid:25784053 a(PUBCHEM:10521421) decreases act(p(FPLX:AKT))
pmid:25784053 a(PUBCHEM:10521421) increases bp(GO:autophagy)
pmid:25784053 a(CHEBI:fluphenazine) increases bp(GO:autophagy)
pmid:25784053 a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP)
pmid:25784053 a(CHEBI:methotrimeprazine) increases bp(GO:autophagy)
pmid:25784053 a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP)
pmid:25784053 a(PUBCHEM:799645) increases bp(GO:autophagy)
pmid:25784053 a(PUBCHEM:799645) decreases p(HGNC:SNCA, var("p.Ala53Thr"))
pmid:25784053 a(PUBCHEM:799645) decreases a(HBP:"huntingtin aggregates")
pmid:25784053 a(PUBCHEM:877863) increases bp(GO:autophagy)
pmid:25784053 a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr"))
pmid:25784053 a(PUBCHEM:877863) decreases a(HBP:"huntingtin aggregates")
pmid:25784053 a(PUBCHEM:1560402) increases bp(GO:autophagy)
pmid:25784053 a(PUBCHEM:1560402) decreases p(HGNC:SNCA, var("p.Ala53Thr"))
pmid:25784053 a(PUBCHEM:1560402) decreases a(HBP:"huntingtin aggregates")
pmid:25784053 composite(a(CHEBI:sirolimus), a(PUBCHEM:799645)) decreases p(HGNC:SNCA, var("p.Ala53Thr"))
pmid:25784053 composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) decreases p(HGNC:SNCA, var("p.Ala53Thr"))
pmid:25784053 composite(a(CHEBI:sirolimus), a(PUBCHEM:1560402)) decreases p(HGNC:SNCA, var("p.Ala53Thr"))
pmid:25784053 a(PUBCHEM:675434) decreases p(HGNC:MAPT)
pmid:23528736 a(PUBCHEM:675434) increases deg(p(HGNC:MAPT))
pmid:25784053 a(PUBCHEM:675434) decreases p(HGNC:TARDBP)
pmid:25784053 a(PUBCHEM:675434) decreases p(HGNC:ATXN3)
pmid:25784053 a(PUBCHEM:675434) decreases act(p(HGNC:USP14))
pmid:23528736 a(PUBCHEM:675434) decreases act(p(HGNC:USP14))
pmid:25784053 a(PUBCHEM:675434) causesNoChange p(FPLX:Proteasome)
pmid:23528736 a(PUBCHEM:675434) increases act(p(FPLX:Proteasome))
pmid:18930136 deg(a(CHEBI:oligopeptide)) increases a(CHEBI:"amino acid")
pmid:18930136 bp(GO:"antigen processing and presentation") association bp(GO:autophagy)
pmid:18930136 bp(GO:"autophagosome-lysosome fusion") increases bp(GO:"protein catabolic process")
pmid:18930136 bp(GO:"autophagosome-lysosome fusion") increases bp(GO:autophagy)
pmid:18930136 bp(GO:"autophagy of nucleus") isA bp(GO:macroautophagy)
pmid:18930136 bp(GO:pexophagy) isA bp(GO:macroautophagy)
pmid:18930136 bp(GO:reticulophagy) isA bp(GO:macroautophagy)
pmid:18930136 bp(GO:xenophagy) isA bp(GO:macroautophagy)
pmid:18930136 bp(GO:ribophagy) isA bp(GO:macroautophagy)
pmid:18930136 bp(GO:aggrephagy) isA bp(GO:macroautophagy)
pmid:18930136 a(GO:phagophore) increases a(GO:autophagosome)
pmid:18930136 composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases complex(p(HGNC:ATG12), p(HGNC:ATG5))
pmid:18930136 composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases a(GO:phagophore)
pmid:18930136 complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5))
pmid:18930136 complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases p(HGNC:GABARAPL2, pmod(GO:"protein lipidation"))
pmid:18930136 p(HGNC:ATG5) decreases path(HBP:Neurodegeneration)
pmid:18930136 complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) increases a(GO:phagophore)
pmid:18930136 p(HGNC:GABARAPL2) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2))
pmid:18930136 p(HGNC:ATG4A) increases p(HGNC:GABARAPL2, frag("?"))
pmid:18930136 p(HGNC:ATG4A) increases complex(p(HGNC:ATG4A), p(HGNC:ATG7))
pmid:18930136 composite(p(HGNC:ATG12), p(HGNC:ATG3), p(HGNC:ATG5)) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2, frag("?")))
pmid:18930136 complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) increases a(GO:amphisome)
pmid:18930136 complex(a(GO:amphisome), a(GO:lysosome)) increases a(GO:autolysosome)
pmid:18930136 p(HGNC:GABARAP) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAP))
pmid:18930136 complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) increases complex(a(CHEBI:phosphatidylethanolamine), a(GO:phagophore), p(HGNC:MAP1LC3B))
pmid:18930136 complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) association a(GO:autophagosome)
pmid:18930136 path(MESH:"Creutzfeldt-Jakob Syndrome") positiveCorrelation a(GO:autophagosome)
pmid:18930136 path(MESH:"Neuronal Ceroid-Lipofuscinoses") negativeCorrelation act(a(GO:lysosome))
pmid:18930136 p(HGNC:CLN3, var("?")) increases path(MESH:"Neuronal Ceroid-Lipofuscinoses")
pmid:18930136 p(HGNC:ATP13A2, var("?")) increases bp(GO:"proteasomal protein catabolic process")
pmid:18930136 p(HGNC:ATP13A2, var("?")) increases path(HBP:Neurodegeneration)
pmid:18930136 p(HGNC:RAB7A, var("?")) decreases bp(GO:"autophagosome-lysosome fusion")
pmid:18930136 a(MESH:Dyneins) increases bp(GO:"autophagosome-lysosome fusion")
pmid:26631930 act(a(MESH:Dyneins)) association p(HGNC:MAPT)
pmid:18930136 p(HGNC:DCTN1, var("?")) positiveCorrelation a(GO:autophagosome)
pmid:8391280 p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection")
pmid:8391280 p(HGNC:DCTN1) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT))
pmid:8391280 p(HGNC:DCTN1) isA p(INTERPRO:"Dynein associated protein")
pmid:18930136 a(CHEBI:"lithium(1+)") increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:"lithium(1+)") increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:"lithium(1+)") increases bp(GO:autophagy)
pmid:18930136 a(CHEBI:"lithium(1+)") decreases path(HBP:Neurodegeneration)
pmid:30116051 a(CHEBI:"lithium(1+)") decreases act(p(HGNC:IMPA1))
pmid:30116051 a(CHEBI:"lithium(1+)") decreases a(PUBCHEM:55310)
pmid:30116051 a(CHEBI:"lithium(1+)") decreases p(HGNC:SNCA)
pmid:30116051 a(CHEBI:"lithium(1+)") decreases p(HGNC:SOD1)
pmid:30116051 a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT)
pmid:30116051 a(CHEBI:"lithium(1+)") decreases p(HGNC:MAPT)
pmid:30116051 a(CHEBI:"lithium(1+)") increases bp(GO:"motor behavior")
pmid:18930136 bp(GO:"protein monoubiquitination") increases bp(GO:endocytosis)
pmid:18930136 a(GO:aggresome) negativeCorrelation bp(GO:"cell death")
pmid:18930136 composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases bp(GO:"apoptotic process")
pmid:18930136 composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases p(MESH:Proteins, pmod(Ub))
pmid:18930136 p(HGNC:HDAC6) regulates bp(GO:autophagy)
pmid:18930136 p(HGNC:HDAC6) increases bp(GO:autophagy)
pmid:18930136 p(HGNC:HDAC6) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:18930136 p(HGNC:HDAC6) regulates a(GO:aggresome)
pmid:18930136 p(HGNC:HDAC6) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytoplasm), toLoc(GO:lysosome))
pmid:18930136 p(HGNC:HDAC6) increases bp(GO:"Hsp90 deacetylation")
pmid:18930136 p(HGNC:HDAC6) regulates complex(GO:"chaperone complex")
pmid:18930136 p(HGNC:HDAC6) increases bp(GO:"ubiquitin-dependent protein catabolic process")
pmid:28803412 p(HGNC:HDAC6) decreases a(HBP:HBP00093)
pmid:30640040 p(HGNC:HDAC6) association a(PUBCHEM:53340666)
pmid:29311797 p(HGNC:HDAC6) increases act(p(HGNC:AIP))
pmid:29311797 p(HGNC:HDAC6) association a(HBP:"Tau aggregates")
pmid:26751493 p(HGNC:HDAC6) association p(HBP:"microtubule-binding region")
pmid:26631930 p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(Ac, Lys))
pmid:26751493 p(HGNC:HDAC6) association a(HBP:"microtubule-binding region")
pmid:25031639 act(p(HGNC:HDAC6)) positiveCorrelation a(HBP:"Tau epitope, 12E8")
pmid:24844691 act(p(HGNC:HDAC6)) negativeCorrelation p(FPLX:Tubulin, pmod(Ac))
pmid:25546293 act(p(HGNC:HDAC6)) negativeCorrelation p(HGNC:CTNNB1, pmod(Ac, Lys, 49))
pmid:23487739 act(p(HGNC:HDAC6)) negativeCorrelation a(GO:microtubule)
pmid:23487739 act(p(HGNC:HDAC6)) decreases p(INTERPRO:"Tubulin/FtsZ, GTPase domain", pmod(Ac))
pmid:28760828 p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT)
pmid:28760828 p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324))
pmid:29844403 act(p(HGNC:HDAC6)) positiveCorrelation act(p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:18930136 p(HGNC:WDFY3) regulates bp(GO:autophagy)
pmid:18930136 p(HGNC:WDFY3) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:18930136 p(HGNC:WDFY3) regulates a(GO:aggresome)
pmid:18930136 tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) increases bp(GO:"protein ubiquitination")
pmid:18930136 p(HGNC:WDFY3) increases bp(GO:"ubiquitin-dependent protein catabolic process")
pmid:18930136 bp(GO:"Hsp90 deacetylation") increases act(p(HGNC:HSF1))
pmid:24563850 a(CHEBI:radical) association bp(GO:"detection of redox state")
pmid:24563850 a(CHEBI:radical) regulates bp(GO:"intracellular receptor signaling pathway")
pmid:24563850 a(CHEBI:radical) regulates bp(MESH:Metabolism)
pmid:24563850 a(CHEBI:radical) decreases a(MESH:Antioxidants)
pmid:24563850 a(CHEBI:radical) association bp(MESH:"Host-Pathogen Interactions")
pmid:24563850 a(CHEBI:radical) increases bp(HBP:"non-enzymatic protein modification")
pmid:24563850 a(CHEBI:radical) increases bp(HBP:misfolding)
pmid:24563850 a(CHEBI:radical) increases bp(GO:"protein oxidation")
pmid:24563850 a(CHEBI:radical) increases bp(MESH:"Protein Carbonylation")
pmid:24563850 act(p(HGNC:XDH)) increases a(CHEBI:radical)
pmid:24563850 act(p(HGNC:XDH)) increases a(CHEBI:"reactive oxygen species")
pmid:24563850 act(p(HGNC:XDH)) increases a(CHEBI:"reactive nitrogen species")
pmid:24563850 act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:radical)
pmid:24563850 act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive oxygen species")
pmid:24563850 act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive nitrogen species")
pmid:24563850 act(a(MESH:Peroxisomes)) increases a(CHEBI:radical)
pmid:24563850 act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive oxygen species")
pmid:24563850 act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive nitrogen species")
pmid:24563850 bp(GO:"response to radiation") increases a(CHEBI:radical)
pmid:24563850 a(MESH:"Air Pollution") increases a(CHEBI:radical)
pmid:24563850 bp(GO:"detection of redox state") association a(CHEBI:radical)
pmid:24563850 bp(MESH:"Host-Pathogen Interactions") association a(CHEBI:radical)
pmid:24563850 bp(HBP:"non-enzymatic protein modification") positiveCorrelation bp(GO:aging)
pmid:24563850 bp(HBP:"non-enzymatic protein modification") increases bp(HBP:misfolding)
pmid:24563850 p(HGNCGENEFAMILY:"Small heat shock proteins") decreases path(MESH:"Protein Aggregation, Pathological")
pmid:24563850 bp(GO:"post-translational protein modification") regulates p(HGNCGENEFAMILY:"Small heat shock proteins")
pmid:24563850 p(HGNC:EIF2A) association p(HGNC:HSPB8)
pmid:24563850 bp(GO:"cellular response to heat") increases p(HGNC:HSPA1A, loc(MESH:"Extracellular Space"))
pmid:24563850 p(HGNC:CAT) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:dioxygen), a(CHEBI:water)))
pmid:29626319 tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CHEBI:"amyloid-beta")
pmid:24563850 p(HGNC:GPX1) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:water)))
pmid:24563850 act(p(HGNC:KEAP1)) increases deg(p(HGNC:NFE2L2))
pmid:29121589 p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2))
pmid:29121589 p(HGNC:KEAP1) isA p(ECCODE:"2.3.2.27")
pmid:24563850 complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:NQO1)
pmid:24563850 complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:HMOX1)
pmid:24563850 complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:GCLC)
pmid:24563850 complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(FPLX:GST)
pmid:24563850 bp(GO:"protein oxidation") association bp(GO:aging)
pmid:24563850 bp(GO:"protein oxidation") association path(MESH:"Cardiovascular Diseases")
pmid:24563850 bp(GO:"protein oxidation") association bp(HP:Neurodegeneration)
pmid:24563850 bp(GO:"protein oxidation") association path(MESH:Neoplasms)
pmid:29024336 bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body"))
pmid:24563850 path(MESH:"Cardiovascular Diseases") association bp(GO:"protein oxidation")
pmid:26195256 path(MESH:"Cardiovascular Diseases") association path(MESH:"Alzheimer Disease")
pmid:24563850 bp(MESH:"Protein Carbonylation") increases a(MESH:"Protein Aggregates")
pmid:24563850 p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(GO:"protein oxidation")
pmid:24563850 p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(HBP:misfolding)
pmid:24563850 p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases a(MESH:"Protein Aggregates")
pmid:24563850 act(p(FPLX:PRDX)) decreases a(MESH:"Protein Aggregates")
pmid:25036637 p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:BAG2), p(HGNC:HSPA8), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"))
pmid:25036637 p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:HSF1), p(HGNC:TP53), p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins")
pmid:21882945 p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"proteasomal protein catabolic process")
pmid:21882945 p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:autophagy)
pmid:21882945 p(INTERPRO:"Heat shock protein 70 family") increases act(p(HGNC:STUB1))
pmid:21882945 p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein catabolic process")
pmid:21882945 p(INTERPRO:"Heat shock protein 70 family") increases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:21882945 act(p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT))
pmid:21882945 act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT)
pmid:18500754 p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule)
pmid:25036637 p(INTERPRO:"Heat shock protein Hsp90 family") association p(INTERPRO:"NudC family")
pmid:29844403 act(p(INTERPRO:"Heat shock protein Hsp90 family")) positiveCorrelation act(p(HGNC:HDAC6))
pmid:25036637 p(HGNC:DNAJC7) increases complex(p(HGNC:DNAJC7), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:DNAJB6) increases complex(p(HGNC:DNAJB6), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:HSPBP1) increases complex(p(HGNC:HSPBP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:EDRF1) increases complex(p(HGNC:EDRF1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:RNF41) increases complex(p(HGNC:RNF41), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(HGNC:STIP1))
pmid:25036637 p(INTERPRO:"Cdc37, N-terminal domain") increases act(p(HGNC:CDC37))
pmid:25036637 complex(p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) regulates complex(p(HGNC:ARAF), p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain"))
pmid:25036637 p(INTERPRO:"Tetratricopeptide repeat") increases complex(a(MESH:"Tacrolimus Binding Proteins"), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK11A), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK1), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKG))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK4), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FER), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CHUK), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:RAF1))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) association p(HGNC:CDC37)
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO1), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO2), p(HGNC:FKBP5))
pmid:25036637 p(HGNC:FKBP5) association p(HGNC:EGLN1)
pmid:25036637 p(HGNC:FKBP5) association p(HGNC:PDCD2)
pmid:25036637 p(HGNC:FKBP5) association p(HGNC:ANKMY2)
pmid:25036637 p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCM4))
pmid:25036637 p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP))
pmid:25036637 p(HGNC:FKBP5) regulates bp(GO:"cellular response to DNA damage stimulus")
pmid:21882945 p(HGNC:FKBP5) regulates complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:21882945 p(HGNC:FKBP5) increases complex(p(FPLX:HSP90), p(HGNC:MAPT))
pmid:20071522 p(HGNC:FKBP5) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:MAPT))
pmid:21882945 p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:MAPT))
pmid:20071522 p(HGNC:FKBP5) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT))
pmid:21882945 p(HGNC:FKBP5) positiveCorrelation bp(GO:aging)
pmid:21882945 p(HGNC:FKBP5) increases p(HGNC:MAPT)
pmid:20071522 p(HGNC:FKBP5) increases p(HGNC:MAPT)
pmid:21882945 p(HGNC:FKBP5) increases p(HGNC:MAPT, pmod(Ph))
pmid:29311797 p(HGNC:FKBP5) isA a(MESH:Immunophilins)
pmid:20071522 p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:20071522 p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:20071522 p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:20071522 p(HGNC:FKBP5) negativeCorrelation complex(p(HGNC:AHSA1), p(HGNC:MAPT))
pmid:20071522 p(HGNC:FKBP5) decreases complex(p(HGNC:MAPT), p(HGNC:PTGES3))
pmid:20071522 p(HGNC:FKBP5) increases bp(GO:"microtubule polymerization")
pmid:29686391 p(HGNC:CDK4) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:26631930 p(HGNC:ABL2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394))
pmid:25036637 p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO1), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO2), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:AGO1) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis")
pmid:25036637 p(HGNC:AGO2) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis")
pmid:25036637 bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO1)
pmid:25036637 bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO2)
pmid:25036637 p(HGNC:EGLN1) association p(HGNC:FKBP5)
pmid:25036637 p(HGNC:EGLN1) association p(INTERPRO:"Zinc finger, MYND-type")
pmid:25036637 p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:EGLN1)
pmid:25036637 p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:EGLN1), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:PDCD2)
pmid:25036637 p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:PDCD2), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:ANKMY2)
pmid:25036637 p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:ANKMY2), p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 p(HGNC:PDCD2) association p(HGNC:FKBP5)
pmid:25036637 p(HGNC:PDCD2) association p(INTERPRO:"Zinc finger, MYND-type")
pmid:25036637 p(HGNC:ANKMY2) association p(HGNC:FKBP5)
pmid:25036637 p(HGNC:ANKMY2) association p(INTERPRO:"Zinc finger, MYND-type")
pmid:25036637 p(HGNC:MCMBP) increases bp(GO:"DNA replication initiation")
pmid:25036637 p(HGNC:MCMBP) increases bp(GO:"replication fork progression beyond termination site")
pmid:25036637 p(HGNC:MCMBP) increases complex(p(HGNC:MCM2), p(HGNC:MCMBP))
pmid:25036637 p(HGNC:MCMBP) increases complex(p(HGNC:MCM3), p(HGNC:MCMBP))
pmid:25036637 p(HGNC:MCMBP) increases complex(p(HGNC:MCM4), p(HGNC:MCMBP))
pmid:25036637 p(HGNC:MCMBP) increases complex(p(HGNC:MCM5), p(HGNC:MCMBP))
pmid:25036637 p(HGNC:MCMBP) increases complex(p(HGNC:MCM6), p(HGNC:MCMBP))
pmid:25036637 p(HGNC:MCMBP) increases complex(p(HGNC:MCM7), p(HGNC:MCMBP))
pmid:25036637 p(HGNC:MCMBP) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP))
pmid:23702978 bp(GO:"cellular response to DNA damage stimulus") increases complex(GO:ripoptosome)
pmid:25036637 p(HGNC:FKBP8) increases complex(p(HGNC:FKBP8), p(HGNC:PDCL))
pmid:25036637 p(HGNC:FKBP8) association bp(GO:"G protein-coupled receptor signaling pathway")
pmid:29311797 p(HGNC:FKBP8) isA a(MESH:Immunophilins)
pmid:25036637 p(HGNC:PDCL) association p(INTERPRO:"G-protein, gamma subunit")
pmid:25036637 p(HGNC:PDCL) isA a(MESH:"Molecular Chaperones")
pmid:25036637 bp(GO:"G protein-coupled receptor signaling pathway") association p(HGNC:FKBP8)
pmid:25036637 p(INTERPRO:"G-protein, gamma subunit") association p(HGNC:PDCL)
pmid:25036637 p(HGNC:FKBP6) increases complex(p(HGNC:FKBP6), p(HGNC:OSBP))
pmid:29311797 p(HGNC:FKBP6) isA a(MESH:Immunophilins)
pmid:25036637 a(HBP:"OSW-1") decreases complex(p(HGNC:FKBP6), p(HGNC:OSBP))
pmid:25036637 p(INTERPRO:"BAG domain") regulates act(p(INTERPRO:"Heat shock protein 70 family"))
pmid:25036637 p(HGNC:LTN1) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins")
pmid:25036637 bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:LTN1)
pmid:21882945 bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(MESH:"Molecular Chaperones")
pmid:25036637 p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD1L1))
pmid:25036637 p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD2L1))
pmid:25036637 p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DCP1A))
pmid:25036637 p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:EDC3))
pmid:25036637 p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DDX6))
pmid:25036637 p(HGNC:BAG4) negativeCorrelation complex(GO:"P-body")
pmid:25036637 p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:HSPB1))
pmid:25036637 p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:DCP1B))
pmid:25036637 p(HGNC:DCP1A) association bp(GO:"cellular protein catabolic process")
pmid:25036637 p(HGNC:DCP1A) association bp(GO:"gene silencing")
pmid:25036637 p(HGNC:EDC3) association bp(GO:"cellular protein catabolic process")
pmid:25036637 p(HGNC:EDC3) association bp(GO:"gene silencing")
pmid:25036637 p(HGNC:DDX6) association bp(GO:"cellular protein catabolic process")
pmid:25036637 p(HGNC:DDX6) association bp(GO:"gene silencing")
pmid:25036637 complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4)
pmid:25036637 complex(GO:"P-body") association p(HGNC:BAG4, var("p.Asp424Ala"))
pmid:25036637 complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4, var("p.Asp424Ala"))
pmid:25036637 p(HGNC:BAG4, var("p.Asp424Ala")) decreases complex(p(HGNC:BAG4, var("p.Asp424Ala")), p(INTERPRO:"Heat shock protein 70 family"))
pmid:25036637 p(HGNC:BAG4, var("p.Asp424Ala")) association complex(GO:"P-body")
pmid:25036637 p(HGNC:BAG4, var("p.Asp424Ala")) negativeCorrelation complex(GO:"P-body")
pmid:25036637 a(PUBCHEM:23624255) decreases act(p(INTERPRO:"Heat shock protein Hsp90 family"))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1))
pmid:25036637 a(PUBCHEM:23624255) increases complex(p(HGNC:BAG3), p(HGNC:HSPA8))
pmid:25036637 a(PUBCHEM:23624255) increases complex(p(HGNC:BAG1), p(HGNC:HSPA8))
pmid:25036637 a(PUBCHEM:23624255) increases complex(p(HGNC:BAG4), p(HGNC:HSPA8))
pmid:25036637 a(PUBCHEM:23624255) increases complex(p(HGNC:BAG5), p(HGNC:HSPA8))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:HSPA8), p(HGNC:SUGT1))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSPA8))
pmid:25036637 a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSPA8))
pmid:25036637 a(PUBCHEM:23624255) increases complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6))
pmid:25036637 a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSP90AB1))
pmid:25036637 a(PUBCHEM:23624255) increases complex(p(HGNC:HSPA8), p(HGNC:SIRT6))
pmid:25036637 a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSPA8))
pmid:25036637 p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:RPAP3))
pmid:25036637 p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:RPAP3))
pmid:25036637 p(HGNC:RPAP3) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:RPAP3))
pmid:25036637 p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily"))
pmid:25036637 p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat"))
pmid:29311797 p(HGNC:FKBP4) isA a(MESH:Immunophilins)
pmid:29311797 p(HGNC:FKBP4) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:FKBP4) increases a(HBP:"Tau aggregates")
pmid:26903089 act(p(HGNC:FKBP4)) association p(HBP:"VQIVYK motif")
pmid:21882945 p(HGNC:BAG2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 p(HGNC:BAG2) association deg(p(HGNC:MAPT, pmod(Ph)))
pmid:21882945 p(HGNC:BAG2) decreases act(p(HGNC:STUB1))
pmid:21882945 p(HGNC:BAG2) decreases bp(GO:"protein ubiquitination")
pmid:21882945 p(HGNC:BAG2) decreases complex(p(HGNC:STUB1), p(HGNC:UBA2))
pmid:25036637 p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMC2))
pmid:25036637 p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD2))
pmid:25036637 p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5))
pmid:25036637 p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5))
pmid:25036637 p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5))
pmid:25036637 p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN2))
pmid:25036637 p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA6), p(INTERPRO:"BAG domain superfamily"))
pmid:25036637 p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA8), p(INTERPRO:"BAG domain superfamily"))
pmid:25036637 p(HGNC:UNC45A) directlyIncreases complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A))
pmid:25036637 p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2))
pmid:25036637 p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:PSMD2))
pmid:25036637 p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:PSMD2))
pmid:25036637 p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG5), p(HGNC:PSMD2))
pmid:25036637 p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:STUB1))
pmid:25036637 p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT))
pmid:21882945 complex(p(FPLX:HSP90), p(HGNC:STUB1)) association p(HGNC:AKT1)
pmid:25374103 complex(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded)))
pmid:25036637 p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:VBP1))
pmid:25036637 p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:VBP1))
pmid:25036637 p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:VBP1))
pmid:25036637 p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:UXT))
pmid:25036637 p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:UXT))
pmid:25036637 p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:UXT))
pmid:25036637 p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2), p(HGNC:PFDN5))
pmid:25036637 p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2))
pmid:25036637 p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN5))
pmid:25036637 p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:POLR3A))
pmid:25036637 p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:POLR3A), p(HGNC:RPAP3))
pmid:25036637 p(HGNC:POLR3A) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:POLR3A))
pmid:25036637 p(HGNC:URI1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:URI1))
pmid:25036637 p(HGNC:URI1) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:URI1))
pmid:25036637 p(HGNC:URI1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:URI1))
pmid:25036637 p(INTERPRO:"Leucine-rich repeat domain superfamily") directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily"))
pmid:25036637 a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C))
pmid:25036637 a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PTGES3))
pmid:21882945 p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(Ph))
pmid:29311797 act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:21882945 p(HGNC:PTGES3) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90))
pmid:29311797 p(HGNC:PTGES3) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity"))
pmid:29311797 p(HGNC:PTGES3) decreases path(MESH:"Protein Aggregation, Pathological")
pmid:29311797 p(HGNC:PTGES3) increases p(HGNC:MAPT)
pmid:29311797 p(HGNC:PTGES3) increases p(HGNC:MAPT, pmod(Ph))
pmid:29311797 p(HGNC:PTGES3) decreases bp(GO:"cell death in response to oxidative stress")
pmid:25036637 p(INTERPRO:"NudC family") association p(INTERPRO:"Heat shock protein Hsp90 family")
pmid:25036637 p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain superfamily"))
pmid:25036637 p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain"))
pmid:25036637 p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain"))
pmid:25036637 p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL13), p(HGNC:NUDCD3))
pmid:25036637 p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL1), p(HGNC:NUDCD3))
pmid:25036637 p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:ENC1), p(HGNC:NUDCD3))
pmid:25036637 p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller"))
pmid:25036637 p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller"))
pmid:25036637 p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:FBXO24), p(HGNC:NUDCD2))
pmid:25036637 p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(HGNC:SNX31))
pmid:25036637 p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1"))
pmid:25036637 p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1"))
pmid:25036637 p(HGNC:CFAP100) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37))
pmid:25036637 p(HGNC:NUDCD1) directlyIncreases complex(p(HGNC:NUDCD1), p(INTERPRO:"DEAD/DEAH box helicase domain"))
pmid:25036637 p(HGNC:NUDCD1) directlyIncreases complex(a(GO:"COPI-coated vesicle"), p(HGNC:NUDCD1))
pmid:25036637 a(GO:"COPI-coated vesicle") regulates bp(GO:"retrograde transport, vesicle recycling within Golgi")
pmid:24706768 a(HBP:"polyQ aggregates") decreases act(p(HGNC:DNAJB1))
pmid:24706768 a(HBP:"polyQ aggregates") decreases bp(GO:endocytosis)
pmid:24706768 a(HBP:"Q82 aggregates") decreases bp(GO:"clathrin-dependent endocytosis")
pmid:24706768 p(HGNC:SOD1, var("p.Ala4Val")) decreases bp(GO:"clathrin-dependent endocytosis")
pmid:24706768 complex(a(HBP:"protein aggregates"), p(HGNC:HSPA8)) decreases bp(GO:"clathrin-dependent endocytosis")
pmid:28803412 p(HGNC:SNCA, var("p.Glu46Lys")) increases path(MESH:"Parkinson Disease")
pmid:28803412 p(HGNC:SNCA, var("p.His50Gln")) increases path(MESH:"Parkinson Disease")
pmid:28803412 p(HGNC:SNCA, var("p.Gly51Asp")) increases path(MESH:"Parkinson Disease")
pmid:28803412 p(HGNC:SNCA, var("p.Ala53Glu")) increases path(MESH:"Parkinson Disease")
pmid:28803412 a(HBP:HBP00016) increases path(MESH:"Parkinson Disease")
pmid:27075649 a(HBP:HBP00016) positiveCorrelation path(MESH:"Parkinson Disease")
pmid:27075649 a(HBP:HBP00016) positiveCorrelation path(MESH:"Multiple System Atrophy")
pmid:27075649 a(HBP:HBP00016) positiveCorrelation path(MESH:"Lewy Body Disease")
pmid:30116051 a(HBP:HBP00016) decreases complex(GO:"proteasome complex")
pmid:28803412 a(HBP:HBP00093) increases path(MESH:"Parkinson Disease")
pmid:28803412 a(HBP:HBP00093) biomarkerFor path(MESH:"Parkinson Disease")
pmid:28803412 a(HBP:HBP00093) positiveCorrelation path(MESH:"Parkinson Disease")
pmid:28803412 a(HBP:HBP00093) increases a(HBP:HBP00092)
pmid:27075649 a(HBP:HBP00093) negativeCorrelation a(HBP:HBP00092)
pmid:28803412 a(HBP:HBP00093) increases bp(GO:"apoptotic process")
pmid:28803412 a(HBP:HBP00093) increases bp(GO:"apoptotic process")
pmid:27075649 a(HBP:HBP00093) increases bp(GO:"apoptotic process")
pmid:28803412 a(HBP:HBP00093) decreases a(MESH:Mitochondria)
pmid:28803412 a(HBP:HBP00093) increases bp(HBP:HBP00037)
pmid:28803412 a(HBP:HBP00093) increases bp(MESH:"Endoplasmic Reticulum Stress")
pmid:28803412 a(HBP:HBP00093) decreases act(complex(GO:"proteasome complex"))
pmid:28803412 a(HBP:HBP00093) increases bp(GO:"microglial cell activation")
pmid:28803412 a(HBP:HBP00093) increases bp(GO:"inflammatory response")
pmid:28803412 a(HBP:HBP00093) increases act(p(HGNC:TLR2))
pmid:28803412 a(HBP:HBP00093) increases a(CHEBI:"reactive oxygen species")
pmid:28803412 a(HBP:HBP00093) decreases a(MESH:"Cell Membrane")
pmid:28803412 a(HBP:HBP00093) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part"))
pmid:27075649 a(HBP:HBP00093) increases a(CHEBI:"calcium(2+)")
pmid:28803412 a(HBP:HBP00093) decreases bp(GO:"synaptic vesicle transport")
pmid:28803412 a(HBP:HBP00093) decreases bp(GO:"axonal transport")
pmid:28803412 a(HBP:HBP00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin))
pmid:28803412 a(HBP:HBP00093) decreases a(MESH:"Golgi Apparatus")
pmid:28803412 a(HBP:HBP00092) causesNoChange bp(GO:"apoptotic process")
pmid:27075649 a(HBP:HBP00092) increases bp(GO:"apoptotic process")
pmid:28803412 a(HBP:HBP00092) increases bp(GO:"inflammatory response")
pmid:28803412 a(HBP:HBP00092) increases bp(GO:"microglial cell activation")
pmid:27075649 a(HBP:HBP00092) increases a(CHEBI:"calcium(2+)")
pmid:27075649 a(HBP:HBP00092) negativeCorrelation a(HBP:HBP00093)
pmid:27075649 a(HBP:HBP00092) increases a(HBP:HBP00016)
pmid:28803412 p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Neurodegenerative Diseases")
pmid:24113872 p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease")
pmid:24113872 act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 149))
pmid:24113872 act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 153))
pmid:24113872 act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205))
pmid:24113872 act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8")
pmid:24113872 act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau aggregates")
pmid:28803412 a(CHEBI:salubrinal) decreases bp(MESH:"Endoplasmic Reticulum Stress")
pmid:28803412 a(CHEBI:salubrinal) decreases a(HBP:HBP00093)
pmid:28803412 complex(a(HBP:HBP00093), p(HGNC:VAMP1)) decreases bp(GO:"SNARE complex assembly")
pmid:26631930 act(a(MESH:Kinesin)) association p(HGNC:MAPT)
pmid:28803412 p(HGNC:USP19) increases sec(p(HGNC:SNCA))
pmid:28803412 a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016)
pmid:28803412 a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018)
pmid:28803412 a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00017)
pmid:29626319 a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(Ph))
pmid:29626319 a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:CALCOCO2)
pmid:29626319 a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:SQSTM1)
pmid:28775333 a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a)
pmid:28775333 a(CHEBI:"(-)-epigallocatechin 3-gallate") negativeCorrelation p(HBP:"3R tau")
pmid:28775333 a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety)
pmid:28775333 a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory)
pmid:28803412 a(HBP:HBP00094) decreases a(HBP:HBP00016)
pmid:28803412 a(HBP:HBP00094) decreases bp(GO:"apoptotic process")
pmid:27075649 path(MESH:"Multiple System Atrophy") positiveCorrelation a(HBP:HBP00016)
pmid:27075649 a(HBP:HBP00095) increases bp(GO:"neuron death")
pmid:27075649 a(HBP:HBP00095) decreases bp(GO:"ion homeostasis")
pmid:27075649 a(HBP:HBP00095) increases a(HBP:HBP00016)
pmid:27075649 a(CHEBI:glutaraldehyde) increases a(HBP:HBP00093)
pmid:29807032 act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response")
pmid:29807032 p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621))
pmid:29807032 path(MESH:"Stress Disorders, Traumatic") increases p(MESH:"corticotropin releasing factor-binding protein")
pmid:23211705 p(MGI:Crh) decreases a(MESH:Estradiol)
pmid:23211705 p(MGI:Crh) regulates p(HGNC:CGB3)
pmid:23211705 p(MGI:Crh) decreases p(HGNC:CGB3)
pmid:23211705 p(MGI:Crh) causesNoChange a(MESH:Progesterone)
pmid:23211705 p(MGI:Crh) decreases a(MESH:Progesterone)
pmid:23211705 p(MGI:Crh) decreases a(MESH:Progesterone)
pmid:25125464 p(MGI:Crh) increases p(HBP:"Tau epitope, AT8")
pmid:25125464 p(MGI:Crh) increases a(HBP:"Tau epitope, PHF1")
pmid:25125464 p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 262))
pmid:25125464 p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 422))
pmid:8940412 act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response")
pmid:8940412 act(p(RGD:Crh)) regulates sec(p(RGD:Pomc))
pmid:8940412 act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1))
pmid:8940412 a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh))
pmid:8940412 a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1))
pmid:8940412 a(CHEBI:antalarmin) negativeCorrelation bp(GO:"inflammatory response")
pmid:8940412 a(CHEBI:antalarmin) decreases sec(p(RGD:Pomc))
pmid:30145931 a(CHEBI:"bafilomycin A1") decreases bp(GO:autophagy)
pmid:30145931 a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome))
pmid:23528736 a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome))
pmid:30145931 a(CHEBI:epoxomicin) increases bp(GO:"protein ubiquitination")
pmid:30145931 a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:30145931 a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:30145931 a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:30145931 a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:30145931 a(CHEBI:epoxomicin) decreases a(MESH:"Dendritic Spines")
pmid:24027553 a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3))
pmid:24027553 a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT))
pmid:24027553 a(CHEBI:epoxomicin) increases p(HGNC:MAPT)
pmid:23528736 a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT))
pmid:30145931 p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(HBP:"amyloid-beta oligomers")
pmid:30145931 p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:wortmannin)
pmid:30145931 p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:epoxomicin)
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"actin filament bundle assembly")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:17493042 p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
pmid:17493042 p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:21367866 p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:CDC37)
pmid:22156579 p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin))
pmid:22156579 p(HGNC:MAPT, pmod(Ph, Ser, 356)) partOf a(HBP:"Tau epitope, 12E8")
pmid:22833681 p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation"))
pmid:30145931 p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation a(HBP:"amyloid-beta oligomers")
pmid:28784767 p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8")
pmid:18239272 p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8")
pmid:24760868 p(HGNC:MAPT, pmod(Ph, Thr, 205)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines"))
pmid:29191965 p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22817713 p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau aggregates")
pmid:22817713 p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau oligomers")
pmid:22486774 p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(HBP:"Tau oligomers")
pmid:14612456 p(HGNC:MAPT, pmod(Ph, Thr, 205)) isA p(HGNC:MAPT, pmod(Ph))
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(FPLX:PKA)
pmid:26118667 p(HGNC:MAPT, pmod(Ph, Thr, 205)) negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:22833681 p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation"))
pmid:24406748 p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser"))
pmid:23294633 p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:22253473 p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(GO:"neurofibrillary tangle")
pmid:30145931 a(CHEBI:rolipram) increases act(p(FPLX:Proteasome))
pmid:30145931 a(CHEBI:rolipram) decreases p(HGNC:MAPT, loc(MESH:Dendrites))
pmid:29626319 a(CHEBI:rolipram) increases deg(p(HGNC:MAPT))
pmid:29626319 a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP")
pmid:26692334 a(CHEBI:rolipram) directlyDecreases act(p(FPLX:PDE4))
pmid:26692334 a(CHEBI:rolipram) positiveCorrelation act(p(FPLX:PKA))
pmid:26692334 a(CHEBI:rolipram) increases act(complex(GO:"proteasome complex"))
pmid:26692334 a(CHEBI:rolipram) decreases a(HBP:"Tau aggregates")
pmid:30145931 a(CHEBI:cycloheximide) decreases bp(GO:translation)
pmid:30145931 a(CHEBI:cycloheximide) decreases p(HGNC:MAPT, loc(MESH:Dendrites))
pmid:23702978 a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway")
pmid:30145931 a(CHEBI:"(-)-anisomycin") decreases bp(GO:translation)
pmid:30145931 a(CHEBI:"(-)-anisomycin") decreases p(HGNC:MAPT, loc(MESH:Dendrites))
pmid:22072628 p(HGNC:MAPT, pmod(Ph, Ser, 235)) partOf p(HBP:"proline-rich region 2", pmod(Ph))
pmid:26996941 p(HGNC:MAPT, pmod(Ph, Ser, 235)) association act(p(HGNC:PIN1))
pmid:8282104 a(HBP:HBP00172) directlyIncreases p(HBP:HBP00053, pmod(Ph))
pmid:8282104 complex(a(HBP:HBP00172), p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph))
pmid:8282104 a(HBP:HBP00006) association p(HGNC:CDK5)
pmid:8282104 a(HBP:HBP00006) association p(HGNC:PRKACA)
pmid:8282104 a(HBP:HBP00006) association p(FPLX:ERK)
pmid:8282104 a(HBP:HBP00006) association p(FPLX:GSK3)
pmid:30116051 a(HBP:HBP00006) decreases act(complex(GO:"proteasome complex"))
pmid:30116051 a(HBP:HBP00006) decreases bp(GO:"chaperone-mediated autophagy")
pmid:26458742 a(HBP:HBP00006) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons))
pmid:26458742 a(HBP:HBP00006) causesNoChange bp(GO:"cell death")
pmid:27594586 g(DBSNP:rs63751011) increases p(HGNC:MAP2)
pmid:27594586 g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse")
pmid:27594586 g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7)
pmid:27594586 g(DBSNP:rs63751011) causesNoChange p(HGNC:MAPT)
pmid:27594586 g(DBSNP:rs63751011) causesNoChange p(HGNC:DLGAP4)
pmid:27594586 g(DBSNP:rs63751011) causesNoChange bp(MESH:"Membrane Potentials")
pmid:27594586 g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation")
pmid:27594586 g(DBSNP:rs63751011) increases act(p(HGNC:MMP9))
pmid:27594586 g(DBSNP:rs63751011) increases sec(p(HGNC:MMP9))
pmid:27594586 g(DBSNP:rs63751011) increases r(HGNC:MMP9)
pmid:27594586 g(DBSNP:rs63751011) increases r(HGNC:MMP9)
pmid:27594586 g(DBSNP:rs63751011) increases r(HGNC:MMP2)
pmid:27594586 g(DBSNP:rs63751011) increases r(HGNC:MMP2)
pmid:27594586 g(DBSNP:rs63751011) increases bp(GO:"neuron death")
pmid:27594586 g(DBSNP:rs63751011) increases a(HBP:HBP00045)
pmid:27594586 g(DBSNP:rs63751011) decreases a(HBP:HBP00044)
pmid:27594586 path(MESH:"Neurodevelopmental Disorders") association act(p(HGNC:MMP9))
pmid:27594586 a(CHEBI:staurosporine) increases bp(GO:"apoptotic process")
pmid:8726973 a(CHEBI:staurosporine) decreases act(p(HGNC:CDK5))
pmid:23666762 a(CHEBI:staurosporine) decreases act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin))
pmid:23001711 a(CHEBI:staurosporine) decreases act(p(HGNC:MARK2), ma(kin))
pmid:23001711 a(CHEBI:staurosporine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:27594586 a(CHEBI:rotenone) increases bp(HBP:HBP00037)
pmid:27594586 composite(a(CHEBI:rotenone), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death")
pmid:27594586 composite(a(CHEBI:staurosporine), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death")
pmid:27594586 a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(Ph))
pmid:27594586 a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases sec(p(HGNC:MMP9))
pmid:27594586 a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9))
pmid:27594586 a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2))
pmid:27594586 a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2)
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9))
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9))
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9))
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9))
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases r(HGNC:MMP9)
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph))
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade")
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2))
pmid:27594586 p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2))
pmid:27594586 p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange sec(p(HGNC:MMP9))
pmid:27594586 p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9))
pmid:27594586 p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(Ph))
pmid:30116051 p(HGNC:ULK1, pmod(Ph, Ser, 317)) increases act(p(HGNC:ULK1))
pmid:30116051 p(HGNC:ULK1, pmod(Ph, Ser, 777)) increases act(p(HGNC:ULK1))
pmid:30116051 p(FPLX:mTORC1, pmod(Ph)) decreases act(p(FPLX:mTORC1))
pmid:30116051 p(HGNC:ULK1, pmod(Ph, Ser, 757)) decreases act(p(HGNC:ULK1))
pmid:30116051 p(HGNC:FOXO1) increases bp(GO:macroautophagy)
pmid:30116051 p(HGNC:FOXO3) increases bp(GO:macroautophagy)
pmid:30116051 p(HGNC:ZKSCAN3) decreases bp(GO:macroautophagy)
pmid:30116051 p(HGNC:AMBRA1, pmod(Ph)) increases act(p(HGNC:AMBRA1))
pmid:30116051 act(p(HGNC:AMBRA1)) increases bp(GO:"autophagosome assembly")
pmid:30116051 p(HGNC:BECN1, pmod(Ph)) increases act(p(HGNC:BECN1))
pmid:30116051 p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?"))
pmid:30116051 act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) negativeCorrelation g(HGNC:PSEN1, var("?"))
pmid:30116051 p(HGNC:MAPT, pmod(HBP:HBP00007)) decreases deg(p(HGNC:MAPT))
pmid:30116051 p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease")
pmid:30116051 p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy)
pmid:30116051 p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease")
pmid:30116051 p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy)
pmid:30116051 p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1))
pmid:30116051 p(HGNC:LRRK2, var("?")) association bp(HBP:HBP00073)
pmid:30116051 p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
pmid:30116051 p(HGNC:GBA, var("?")) increases path(MESH:"Gaucher Disease")
pmid:30116051 p(HGNC:GBA, var("?")) decreases bp(GO:autophagy)
pmid:30116051 p(HGNC:GBA, var("?")) increases a(HBP:HBP00016)
pmid:30116051 p(HGNC:GBA, var("?")) increases path(MESH:"Parkinson Disease")
pmid:30116051 p(HGNC:C9orf72) association path(MESH:"Frontotemporal Dementia")
pmid:30116051 p(HGNC:CHMP2B) association path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:30116051 p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:30116051 p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis")
pmid:30116051 p(HGNC:OPTN, var("?")) decreases bp(GO:"cargo loading into vesicle")
pmid:30116051 p(HGNC:TBK1, var("?")) decreases bp(GO:"cargo loading into vesicle")
pmid:30116051 p(HGNC:C9orf72, var("?")) decreases bp(GO:autophagy)
pmid:30116051 a(CHEBI:clonidine) increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:clonidine) increases deg(p(HGNC:HTT))
pmid:30116051 a(CHEBI:Rilmenidine) increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT))
pmid:30116051 p(HGNC:CAPN2) decreases bp(GO:autophagy)
pmid:30116051 p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?")))
pmid:24027553 p(HGNC:CAPN2) positiveCorrelation path(MESH:"Neurofibrillary Tangles")
pmid:30116051 p(HGNC:CAST) decreases act(p(HGNC:CAPN1))
pmid:30116051 p(HGNC:CAST) decreases act(p(HGNC:CAPN2))
pmid:30116051 p(HGNC:CAST) increases bp(GO:autophagy)
pmid:30116051 p(HGNC:CAST) increases deg(p(HGNC:HTT, var("?")))
pmid:30116051 p(HGNC:CAST) increases deg(p(HGNC:MAPT))
pmid:30116051 p(HGNC:CAST) increases deg(p(HGNC:SNCA))
pmid:30116051 p(HGNC:CAST) increases deg(p(HGNC:SOD1))
pmid:30116051 a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN1))
pmid:30116051 a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2))
pmid:30116051 a(CHEBI:Calpeptin) increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:Calpeptin) increases deg(p(HGNC:HTT, var("?")))
pmid:30116051 a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK))
pmid:30116051 a(PUBCHEM:54708532) increases act(p(FPLX:AMPK))
pmid:30116051 a(PUBCHEM:54708532) increases deg(p(HGNC:HTT, var("?")))
pmid:30116051 a(CHEBI:"selenium(2+)") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:30116051 a(CHEBI:selenomethionine) increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:selenomethionine) increases act(p(FPLX:AMPK))
pmid:30116051 a(CHEBI:selenomethionine) increases bp(GO:"autophagosome assembly")
pmid:30116051 a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy")
pmid:30116051 p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5))
pmid:30116051 composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(Ph, Thr, 172))
pmid:30116051 a(CHEBI:metformin) increases act(p(FPLX:AMPK))
pmid:30116051 a(CHEBI:metformin) increases bp(GO:autophagy)
pmid:30116051 a(CHEBI:metformin) decreases a(CHEBI:"amyloid-beta")
pmid:30116051 a(CHEBI:metformin) decreases p(HGNC:MAPT, pmod(HBP:HBP00007))
pmid:30116051 a(CHEBI:metformin) decreases bp(GO:"neuron death")
pmid:23528736 p(HGNC:DCTN4) decreases a(HBP:"Tau aggregates")
pmid:30116051 a(CHEBI:calcitriol) increases act(p(FPLX:AMPK))
pmid:30116051 a(CHEBI:calcitriol) increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:calcitriol) increases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(MESH:Brain), toLoc(MESH:Blood))
pmid:29626319 a(CHEBI:calcitriol) decreases p(HGNC:AGER)
pmid:29626319 a(CHEBI:calcitriol) increases p(HGNC:LRP1)
pmid:30116051 complex(a(CHEBI:sirolimus), p(HGNC:FKBP1A)) decreases act(p(FPLX:mTORC1))
pmid:26631930 p(HGNC:FUS) decreases p(HBP:"4R tau")
pmid:26631930 p(HGNC:FUS) decreases p(HBP:"Tau isoform F (441 aa)")
pmid:26631930 p(HGNC:FUS) decreases p(HBP:"Tau isoform C (410 aa)")
pmid:26631930 p(HGNC:FUS) association path(MESH:"Frontotemporal Lobar Degeneration")
pmid:30116051 a(CHEBI:fisetin) increases bp(GO:macroautophagy)
pmid:30116051 a(CHEBI:fisetin) increases act(p(FPLX:mTORC1))
pmid:30116051 a(CHEBI:fisetin) decreases a(HBP:HBP00018)
pmid:30116051 p(HGNC:ABL1) decreases bp(GO:macroautophagy)
pmid:29191965 p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))
pmid:26631930 p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394))
pmid:17493042 p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 394))
pmid:23687953 act(p(HGNC:ABL1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 363))
pmid:30116051 a(CHEBI:nilotinib) decreases act(p(HGNC:ABL1))
pmid:30116051 a(CHEBI:nilotinib) increases bp(GO:macroautophagy)
pmid:30116051 a(CHEBI:nilotinib) decreases bp(HP:Neurodegeneration)
pmid:30116051 a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:30116051 a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:30116051 a(CHEBI:cilostazol) increases bp(GO:macroautophagy)
pmid:30116051 a(CHEBI:cilostazol) increases p(HGNC:BECN1)
pmid:30116051 a(CHEBI:cilostazol) increases p(HGNC:ATG5)
pmid:30116051 a(CHEBI:cilostazol) increases p(HGNC:MAP1LC3A)
pmid:30116051 a(CHEBI:cilostazol) decreases p(FPLX:mTORC1)
pmid:30116051 a(CHEBI:cilostazol) increases p(HGNC:CTSB)
pmid:30116051 a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1))
pmid:30116051 a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(Ph, Tyr, 172))
pmid:30116051 a(CHEBI:cilostazol) increases bp(GO:cognition)
pmid:30116051 a(CHEBI:cilostazol) decreases p(HGNC:MAPT, pmod(HBP:HBP00007))
pmid:30116051 a(CHEBI:spermidine) decreases p(HGNC:ATG7, pmod(Ac))
pmid:30116051 a(CHEBI:spermidine) decreases p(FPLX:"Histone_H3", pmod(Ac))
pmid:30116051 a(CHEBI:spermidine) increases act(p(HGNC:BECN1))
pmid:30116051 a(CHEBI:spermidine) decreases act(p(HGNC:CASP3))
pmid:30116051 a(CHEBI:Isorhynchophylline) increases p(HGNC:BECN1)
pmid:30116051 a(CHEBI:Isorhynchophylline) decreases a(HBP:HBP00016)
pmid:30116051 complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy)
pmid:30116051 a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14))
pmid:30116051 a(PUBCHEM:16240819) increases bp(GO:macroautophagy)
pmid:30116051 a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration)
pmid:30116051 p(HGNC:MTMR14) decreases act(p(FPLX:PI3K))
pmid:30116051 a(CHEBI:"epothilone A") increases a(GO:microtubule)
pmid:30116051 a(CHEBI:"epothilone D") increases a(GO:microtubule)
pmid:30116051 a(CHEBI:"epothilone D") increases bp(GO:cognition)
pmid:30116051 a(PUBCHEM:129688311) increases bp(GO:"lysosomal lumen acidification")
pmid:30116051 a(PUBCHEM:129688311) decreases a(HBP:HBP00016)
pmid:30116051 a(PUBCHEM:129688311) decreases a(CHEBI:"amyloid-beta")
pmid:30116051 a(CHEBI:"poly(lactic acid) polymer") increases bp(GO:"lysosomal lumen acidification")
pmid:30116051 a(CHEBI:"poly(D,L-lactic acid-co-glycolic acid)") increases bp(GO:"lysosomal lumen acidification")
pmid:30116051 a(PUBCHEM:2880983) increases act(p(HGNC:MCOLN1))
pmid:30116051 act(p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:Lysosomes), toLoc(MESH:Cytoplasm))
pmid:30116051 act(p(HGNC:MCOLN1)) increases bp(GO:"lysosomal lumen acidification")
pmid:30116051 act(p(HGNC:MCOLN1)) decreases a(CHEBI:"amyloid-beta")
pmid:30116051 a(CHEBI:chlorohydroquinone) decreases bp(GO:macroautophagy)
pmid:30116051 a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") increases bp(GO:macroautophagy)
pmid:30116051 a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:30116051 a(CHEBI:ambroxol) increases p(HGNC:GBA)
pmid:30116051 a(CHEBI:ambroxol) increases bp(GO:macroautophagy)
pmid:30116051 a(CHEBI:ambroxol) increases deg(p(HGNC:SNCA))
pmid:30116051 a(CHEBI:ambroxol) decreases p(HGNC:SNCA)
pmid:30116051 a(CHEBI:ambroxol) decreases bp(GO:"response to endoplasmic reticulum stress")
pmid:30116051 a(PUBCHEM:9568077) increases act(p(HGNC:HSF1), ma(tscript))
pmid:30116051 a(PUBCHEM:46216556) decreases act(p(FPLX:HSP90))
pmid:30116051 a(PUBCHEM:46216556) decreases a(HBP:HBP00017)
pmid:30116051 a(PUBCHEM:3086599) increases act(complex(GO:"proteasome complex"))
pmid:30116051 a(PUBCHEM:3086599) increases act(p(FPLX:PKA), ma(kin))
pmid:30116051 complex(p(HGNC:BIRC2), p(HGNC:SOD1)) increases deg(p(HGNC:SOD1))
pmid:23702978 p(HGNC:BIRC2) decreases complex(GO:ripoptosome)
pmid:30116051 p(HGNC:SESN2) increases act(p(FPLX:AMPK))
pmid:30116051 p(HGNC:SESN2) increases bp(GO:macroautophagy)
pmid:30116051 p(HGNC:SESN2) increases bp(GO:macroautophagy)
pmid:30116051 p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:30116051 p(HGNC:PLG) increases deg(p(HGNC:SNCA))
pmid:30116051 p(HGNC:KLK6) increases deg(p(HGNC:SNCA))
pmid:30116051 a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:IDE)
pmid:30116051 a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:IDE))
pmid:30116051 a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:IDE))
pmid:30116051 a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:MME)
pmid:30116051 a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:MME))
pmid:30116051 a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:MME))
pmid:30116051 a(CHEBI:somatostatin) increases p(HGNC:IDE)
pmid:30116051 a(CHEBI:somatostatin) increases sec(p(HGNC:IDE))
pmid:30116051 a(CHEBI:somatostatin) increases act(p(HGNC:IDE))
pmid:29626319 a(CHEBI:somatostatin) increases p(HGNC:IDE)
pmid:30116051 a(CHEBI:somatostatin) increases p(HGNC:MME)
pmid:30116051 a(CHEBI:somatostatin) increases sec(p(HGNC:MME))
pmid:30116051 a(CHEBI:somatostatin) increases act(p(HGNC:MME))
pmid:29626319 a(CHEBI:somatostatin) increases deg(a(CHEBI:"amyloid-beta"))
pmid:30116051 p(HGNC:GRN) increases act(p(HGNC:MME))
pmid:30116051 p(HGNC:GRN) decreases a(HBP:HBP00018)
pmid:30116051 a(CHEBI:rifampicin) increases deg(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:30116051 a(CHEBI:rifampicin) increases act(p(HGNC:LRP1))
pmid:30116051 a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V"))
pmid:30116051 act(p(HGNC:AQP4)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:AQP4) association deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta")
pmid:26195256 act(p(HGNC:AQP4)) decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))
pmid:29626319 p(HGNC:AQP4) increases a(HP:"glymphatic system")
pmid:29626319 p(HGNC:AQP4) increases a(HP:"glymphatic system")
pmid:23484434 a(CHEBI:6872) decreases a(HBP:HBP00006)
pmid:23484434 a(CHEBI:8028) causesNoChange a(HBP:HBP00006)
pmid:23484434 a(CHEBI:44932) causesNoChange a(HBP:HBP00006)
pmid:23484434 a(CHEBI:3647) causesNoChange a(HBP:HBP00006)
pmid:23484434 a(CHEBI:87637) decreases a(HBP:HBP00006)
pmid:23484434 a(CHEBI:22580) decreases a(HBP:HBP00006)
pmid:23484434 a(CHEBI:1457) decreases a(HBP:HBP00018)
pmid:23484434 a(CHEBI:10642) decreases a(HBP:HBP00018)
pmid:23484434 a(CHEBI:4806) decreases a(HBP:HBP00018)
pmid:23484434 a(CHEBI:4806) decreases a(HBP:HBP00006)
pmid:23484434 a(CHEBI:74460) decreases a(HBP:HBP00018)
pmid:23484434 a(HBP:HBP00021) decreases a(HBP:HBP00018)
pmid:23484434 a(HBP:HBP00019) decreases a(HBP:HBP00018)
pmid:23484434 a(CHEBI:90) causesNoChange a(HBP:HBP00006)
pmid:23484434 a(CHEBI:18152) decreases a(HBP:HBP00006)
pmid:23484434 a(CHEBI:3441) decreases a(HBP:HBP00018)
pmid:23484434 a(CHEBI:3441) decreases a(HBP:HBP00006)
pmid:23484434 a(CHEBI:6710) decreases a(HBP:HBP00006)
pmid:23484434 a(CHEBI:6710) decreases a(HBP:HBP00018)
pmid:23484434 a(CHEBI:112284) decreases a(HBP:HBP00006)
pmid:23484434 a(HBP:HBP00020) decreases a(HBP:HBP00006)
pmid:29024336 path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu")))
pmid:29024336 bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt))
pmid:29024336 bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt))
pmid:29024336 bp(GO:"late endosomal microautophagy") increases deg(a(HBP:HBP00053))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Mapt)
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00006)
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00100)
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy")
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu")))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins))
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy")
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autophagosome)
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autolysosome)
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy)
pmid:29024336 p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn2a)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling")
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Rela)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Glb1)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases path(MESH:Tauopathies)
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:"neurofibrillary tangle")
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence")
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation")
pmid:30126037 p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation")
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases p(MGI:Mapt)
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt))
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases a(HBP:HBP00009)
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy")
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy")
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr")))
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins))
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins))
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins))
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:"chaperone-mediated autophagy")
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autophagosome)
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autolysosome)
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy)
pmid:29024336 p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy)
pmid:29024336 complex(a(GO:lysosome), p(MGI:Mapt, var("p.Pro301Leu"))) increases tloc(p(MGI:Mapt, var("p.Pro301Leu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress")
pmid:28019679 a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:28019679 a(CHEBI:paraquat) increases p(HGNC:CASP1)
pmid:28019679 a(CHEBI:paraquat) increases p(HGNC:IL1B)
pmid:29024336 composite(a(CHEBI:thapsigargin), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy")
pmid:29024336 composite(a(CHEBI:paraquat), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy")
pmid:29024336 composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy")
pmid:29024336 composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy")
pmid:29024336 composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy")
pmid:29024336 composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy")
pmid:29024336 composite(a(CHEBI:"ammonium chloride"), a(CHEBI:leupeptin)) decreases bp(GO:"late endosomal microautophagy")
pmid:23528736 a(CHEBI:leupeptin) decreases act(p(FPLX:Proteasome))
pmid:23528736 a(CHEBI:leupeptin) decreases deg(p(HGNC:MAPT))
pmid:29024336 a(HBP:HBP00057) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 a(HBP:HBP00057) increases bp(GO:"chaperone-mediated autophagy")
pmid:29024336 a(HBP:HBP00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 a(HBP:HBP00055) decreases deg(p(MGI:Mapt))
pmid:29024336 a(HBP:HBP00055) decreases bp(GO:"late endosomal microautophagy")
pmid:29024336 a(HBP:HBP00054) decreases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 p(HBP:HBP00053, var("p.Lys280del")) increases a(HBP:HBP00006)
pmid:29024336 p(HBP:HBP00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT))
pmid:29024336 p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 p(HBP:HBP00053, var("p.Lys280delinsProPro")) increases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases a(HBP:HBP00006)
pmid:29024336 p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases tloc(p(HBP:HBP00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)))
pmid:29024336 p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)))
pmid:29024336 p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)))
pmid:29024336 p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29024336 p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")))
pmid:29024336 p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) increases tloc(p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
pmid:29215007 a(HBP:HBP00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:HBP00169)
pmid:29215007 composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin")
pmid:24760868 complex(GO:"filamentous actin") association p(HGNC:MAPT)
pmid:24760868 complex(GO:"filamentous actin") increases p(HGNC:MAPT)
pmid:24760868 complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse))
pmid:17187063 complex(GO:"filamentous actin") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1))
pmid:29215007 a(HBP:HBP00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1))
pmid:29215007 complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169)
pmid:29215007 complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169)
pmid:29215007 a(MESH:Endopeptidases) increases p(HGNC:MAPT, var("?"))
pmid:29215007 p(HGNC:MAPT, frag("244_372")) increases bp(GO:"actin filament bundle assembly")
pmid:29215007 p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly")
pmid:29215007 p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly")
pmid:29215007 p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290")))
pmid:29215007 p(HGNC:MAPT, frag("260_268")) increases bp(MESH:"Protein Structure, Secondary")
pmid:29215007 p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Structure, Secondary")
pmid:29215007 p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Conformation, alpha-Helical")
pmid:29215007 p(HGNC:MAPT, frag("261_268")) increases bp(MESH:"Protein Conformation, alpha-Helical")
pmid:22072628 bp(MESH:"Protein Conformation, alpha-Helical") positiveCorrelation p(HBP:"proline-rich region 2", pmod(Ph))
pmid:22072628 bp(MESH:"Protein Conformation, alpha-Helical") association p(HGNC:MAPT, frag("235_324"))
pmid:29215007 p(HGNC:MAPT, frag("277_280")) increases a(HBP:HBP00170)
pmid:29215007 p(HGNC:MAPT, frag("261_265")) increases a(HBP:HBP00170)
pmid:29215007 complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical")
pmid:29215007 complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_280"))) increases a(HBP:HBP00170)
pmid:29215007 complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_265"))) increases a(HBP:HBP00170)
pmid:29215007 complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_283"))) increases bp(MESH:"Protein Conformation, alpha-Helical")
pmid:29215007 p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290")))
pmid:29215007 p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly")
pmid:29215007 complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical")
pmid:29215007 p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly")
pmid:29215007 p(HGNC:MAPT, frag("315_318")) increases a(HBP:HBP00170)
pmid:29215007 complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical")
pmid:29215007 p(HGNC:MAPT, frag("254_268")) decreases bp(GO:"actin filament bundle assembly")
pmid:29215007 act(p(HGNC:MARK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:29215007 p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:21311567 act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:24251416 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:23001711 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:29215007 act(p(HGNC:MARK2), ma(kin)) increases p(HBP:HBP00098, pmod(Ph))
pmid:29215007 p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 293))
pmid:24251416 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 293))
pmid:29215007 p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 305))
pmid:24251416 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 305))
pmid:29215007 p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 324))
pmid:24251416 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 324))
pmid:29215007 p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:24251416 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:29215007 p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 416))
pmid:24251416 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 416))
pmid:21882945 act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:21882945 act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph))
pmid:21311567 act(p(HGNC:MARK2)) decreases bp(GO:"microtubule polymerization")
pmid:24251416 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 352))
pmid:24251416 act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 413))
pmid:25031639 p(HGNC:MARK2) increases a(HBP:"Tau epitope, 12E8")
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"actin filament bundle assembly")
pmid:17493042 p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
pmid:17493042 p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:24251416 p(HGNC:MAPT, pmod(Ph, Ser, 293)) partOf p(HBP:"tubulin-binding repeat 2")
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases bp(GO:"actin filament bundle assembly")
pmid:24251416 p(HGNC:MAPT, pmod(Ph, Ser, 305)) partOf p(HBP:"tubulin-binding repeat 2")
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"actin filament bundle assembly")
pmid:17493042 p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
pmid:17493042 p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:28760828 p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HBP:"Tau aggregates")
pmid:28760828 p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HGNC:HDAC6)
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:29215007 p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases bp(GO:"actin filament bundle assembly")
pmid:24027553 p(HGNC:MAPT, pmod(Ac)) association path(MESH:"Neurofibrillary Tangles")
pmid:29540553 p(HGNC:MAPT, pmod(Ac)) negativeCorrelation p(MGI:Sirt3)
pmid:27041503 p(HGNC:MAPT, pmod(Ac)) decreases p(HGNC:WWC1)
pmid:20869593 p(HGNC:MAPT, pmod(Ac)) negativeCorrelation act(p(HGNC:SIRT1))
pmid:20869593 p(HGNC:MAPT, pmod(Ac)) positiveCorrelation p(HBP:"Tau epitope, AT8")
pmid:24027553 p(HGNC:MAPT, pmod(HBP:nitration)) association path(MESH:"Neurofibrillary Tangles")
pmid:24027553 p(HGNC:MAPT, frag("1_?")) association path(MESH:"Neurofibrillary Tangles")
pmid:24027553 p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles")
pmid:24027553 act(p(HGNCGENEFAMILY:Aminopeptidases)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT))
pmid:24027553 a(CHEBI:Thrombin) increases bp(GO:coagulation)
pmid:24027553 a(CHEBI:Thrombin) increases bp(HBP:"neurite retraction")
pmid:24027553 a(CHEBI:Thrombin) increases bp(GO:"apoptotic process")
pmid:24027553 a(CHEBI:Thrombin) increases bp(GO:"apoptotic process")
pmid:24027553 a(CHEBI:Thrombin) increases a(HBP:"Tau aggregates")
pmid:24027553 a(CHEBI:Thrombin) association path(MESH:"Neurofibrillary Tangles")
pmid:24027553 act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?"))
pmid:24027553 act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685"))
pmid:24027553 act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685")))
pmid:24027553 act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases))
pmid:24027553 act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT))
pmid:24027553 p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases")
pmid:24027553 act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "35kD"))
pmid:24027553 act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD"))
pmid:24027553 act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD"))
pmid:24027553 act(p(HGNCGENEFAMILY:Calpains)) association a(HBP:Excitotoxicity)
pmid:24027553 act(p(HGNCGENEFAMILY:Calpains)) increases path(HBP:Neurodegeneration)
pmid:24027553 act(p(HGNC:NPEPPS)) association a(MESH:Brain)
pmid:24027553 p(HGNC:NPEPPS) positiveCorrelation p(MGI:Mapt, var("p.P301L"))
pmid:24027553 p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.P301L"))
pmid:24027553 p(HGNC:NPEPPS) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:24027553 p(HGNC:NPEPPS) decreases path(MESH:Tauopathies)
pmid:24027553 p(HGNC:NPEPPS) decreases p(HGNC:MAPT)
pmid:24027553 p(HGNC:NPEPPS) regulates deg(p(HGNC:MAPT))
pmid:24027553 p(HGNC:NPEPPS) decreases path(MESH:Paralysis)
pmid:24027553 p(HGNC:NPEPPS) decreases path(MESH:Gliosis)
pmid:24027553 p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("1_?"))
pmid:24027553 p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*"))
pmid:24027553 p(HGNC:NPEPPS) association bp(GO:autophagy)
pmid:24027553 p(HGNC:MAPT, var("p.P301L")) association path(MESH:"Frontotemporal Dementia")
pmid:24027553 p(MGI:Mapt, var("p.P301L")) association path(HBP:Neurodegeneration)
pmid:24027553 p(MGI:Mapt, var("p.P301L")) positiveCorrelation p(HGNC:NPEPPS)
pmid:24027553 p(HGNC:PIN1) association path(MESH:"Alzheimer Disease")
pmid:24027553 p(HGNC:PIN1) decreases deg(p(HGNC:MAPT, var("p.P301L")))
pmid:26751493 p(HGNC:PIN1) association p(HBP:"projection domain")
pmid:26751493 p(HGNC:PIN1) association a(HBP:"projection domain")
pmid:25899010 p(HGNC:PIN1) decreases a(HBP:Excitotoxicity)
pmid:25899010 p(HGNC:PIN1) negativeCorrelation p(HGNC:DAPK1)
pmid:24964035 p(HGNC:PIN1) increases deg(p(HGNC:SMAD2))
pmid:24964035 p(HGNC:PIN1) increases complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:SMAD2))
pmid:23157676 act(p(HGNC:PIN1)) decreases p(HBP:"cis p-tau")
pmid:26996941 act(p(HGNC:PIN1)) association p(HGNC:MAPT, pmod(Ph, Ser, 235))
pmid:22926167 act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:19401603 act(p(HGNC:PIN1)) positiveCorrelation act(p(HGNC:PPP2CA))
pmid:19401603 act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212))
pmid:24027553 deg(p(HGNC:MAPT, frag("561_685"))) increases a(HBP:"Tau aggregates")
pmid:24027553 p(HGNC:MAPT, frag("561_685")) increases a(HBP:"Tau aggregates")
pmid:24027553 p(HBP:"cis p-tau") decreases deg(p(HBP:"cis p-tau"))
pmid:24027553 p(HBP:"cis p-tau") decreases act(p(HGNC:PIN1))
pmid:23157676 p(HBP:"cis p-tau") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:23157676 p(HBP:"cis p-tau") increases a(HBP:"Tau aggregates")
pmid:23157676 p(HBP:"cis p-tau") partOf a(HBP:"dystrophic neurite")
pmid:28528849 a(HBP:"Tau fibrils") decreases a(MESH:"Dendritic Spines")
pmid:29686391 a(HBP:"Tau fibrils") causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28420982 a(HBP:"Tau fibrils") increases a(GO:"neurofibrillary tangle")
pmid:24027553 p(HGNC:MAPT, frag("?", "17kD")) association bp(GO:"apoptotic process")
pmid:24027553 p(HGNC:MAPT, frag("?", "17kD")) increases bp(HBP:"neurite retraction")
pmid:24027553 p(HGNC:MAPT, frag("?", "17kD")) causesNoChange path(HBP:neurotoxicity)
pmid:24027553 a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD"))
pmid:24027553 a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD"))
pmid:24027553 a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD"))
pmid:24027553 a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains))
pmid:24027553 act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*"))
pmid:24027553 act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*"))
pmid:24027553 act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?"))
pmid:24027553 act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?"))
pmid:24027553 act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process")
pmid:24027553 act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.D421*"))
pmid:24027553 act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24027553 p(HGNC:MAPT, var("p.D421*")) isA p(HBP:"Tau C3")
pmid:24027553 p(HBP:"Tau C3") increases bp(GO:"apoptotic process")
pmid:24027553 p(HBP:"Tau C3") increases a(HBP:"Tau aggregates")
pmid:24027553 p(HBP:"Tau C3") increases a(HBP:"Tau aggregates")
pmid:24027553 p(HBP:"Tau C3") negativeCorrelation bp(GO:cognition)
pmid:25374103 p(HBP:"Tau C3") causesNoChange bp(GO:"cell death")
pmid:25374103 p(HBP:"Tau C3") negativeCorrelation p(HGNC:STUB1)
pmid:25374103 p(HBP:"Tau C3") positiveCorrelation act(p(HGNC:CASP3))
pmid:25374103 p(HBP:"Tau C3") negativeCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 p(HBP:"Tau C3") negativeCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:24027553 p(HGNC:MAPT, var("p.D421E")) decreases bp(GO:"apoptotic process")
pmid:24027553 composite(p(HBP:"amyloid-beta oligomers"), p(HGNC:CASP3)) increases p(HBP:"Tau C3")
pmid:24027553 a(MESH:"9-deoxy-delta-9-prostaglandin D2") increases act(p(HGNCGENEFAMILY:Caspases))
pmid:24027553 act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ub)))
pmid:24027553 p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT, pmod(Ub)))
pmid:24027553 act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT))
pmid:24027553 p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT))
pmid:24027553 act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt))
pmid:24027553 act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)))
pmid:24027553 act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:24027553 act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau aggregates"))
pmid:24027553 act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau oligomers"))
pmid:24027553 act(a(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT))
pmid:24027553 a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") increases p(HGNC:MAPT)
pmid:24027553 a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") decreases act(a(CHEBI:"Hsp90 inhibitor"))
pmid:24027553 act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT)
pmid:21882945 a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT))
pmid:21882945 a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90))
pmid:24027553 a(MESH:Autophagosomes) positiveCorrelation a(HBP:"Tau aggregates")
pmid:24027553 path(MESH:"Alzheimer disease, familial, type 3") association p(HGNC:PSEN1)
pmid:24027553 bp(GO:"vacuolar acidification") increases bp(GO:proteolysis)
pmid:24027553 bp(MESH:Autophagy) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24027553 bp(MESH:Autophagy) increases deg(p(HGNC:MAPT))
pmid:24027553 bp(MESH:Autophagy) causesNoChange p(HGNC:MAPT)
pmid:24027553 bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:24027553 bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:24027553 bp(MESH:Autophagy) decreases p(HGNC:MAPT, var("p.P301L"))
pmid:24027553 bp(MESH:Autophagy) decreases a(HBP:"Tau aggregates")
pmid:24027553 bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates"))
pmid:24027553 bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates"))
pmid:24027553 bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates"))
pmid:24027553 bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.P301S"))
pmid:24027553 bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Thr, 212), var("p.P301S"))
pmid:24027553 bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S"))
pmid:24027553 bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death")
pmid:24027553 bp(MESH:Autophagy) increases deg(p(HBP:"Tau C3"))
pmid:24027553 bp(MESH:Autophagy) decreases p(HBP:"Tau C3")
pmid:24027553 bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, AT8")
pmid:24027553 bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, PHF1")
pmid:24027553 bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, 12E8")
pmid:24027553 bp(MESH:Autophagy) increases deg(a(HBP:"Tau oligomers"))
pmid:24027553 composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases p(HGNC:MAPT)
pmid:24027553 composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases deg(p(HGNC:MAPT))
pmid:24027553 a(MESH:"3-methyladenine") decreases bp(MESH:Autophagy)
pmid:24027553 a(MESH:"3-methyladenine") increases p(HGNC:MAPT, frag("?"))
pmid:24027553 a(MESH:Trehalose) increases bp(MESH:Autophagy)
pmid:24027553 a(MESH:Trehalose) increases bp(MESH:Autophagy)
pmid:24027553 a(MESH:Trehalose) increases bp(MESH:Autophagy)
pmid:24027553 a(MESH:Trehalose) decreases a(HBP:"Tau aggregates")
pmid:24027553 a(MESH:Trehalose) decreases p(HGNC:MAPT)
pmid:24027553 p(MGI:Mapt, pmod(Ph)) increases path(HBP:Neurodegeneration)
pmid:30126037 p(MGI:Mapt, pmod(Ph)) causesNoChange p(MGI:Cdkn2a)
pmid:19491104 p(MGI:Mapt, pmod(Ph)) association p(MGI:Mapk8ip1)
pmid:19491104 p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Mapk8ip1))
pmid:19491104 p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Klc1))
pmid:28173111 p(MGI:Mapt, pmod(Ph)) positiveCorrelation r(MGI:Dnm1l)
pmid:24027553 composite(a(MESH:Ubiquitin), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ub))
pmid:16176937 p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt))
pmid:16176937 p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt))
pmid:20133804 act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization")
pmid:20133804 act(p(RGD:Mapt)) increases bp(GO:"neuron projection development")
pmid:27671637 a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))
pmid:27671637 a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))
pmid:22764226 a(HBP:"Tau epitope, PHF1") negativeCorrelation p(MGI:Ppp2ca, pmod(Me))
pmid:22156579 a(HBP:"Tau epitope, PHF1") positiveCorrelation a(HBP:"Tau epitope, 12E8")
pmid:22156579 a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:22156579 a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:25125464 a(HBP:"Tau epitope, PHF1") positiveCorrelation p(MGI:Crhr1)
pmid:19459590 a(HBP:"Tau epitope, PHF1") decreases act(p(HGNC:MAPT))
pmid:25031639 a(HBP:"Tau epitope, PHF1") positiveCorrelation deg(p(HGNC:MAPT))
pmid:22156579 a(HBP:"Tau epitope, PHF1") positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:27671637 a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))
pmid:22156579 a(HBP:"Tau epitope, 12E8") positiveCorrelation a(HBP:"Tau epitope, PHF1")
pmid:25031639 a(HBP:"Tau epitope, 12E8") positiveCorrelation act(p(HGNC:HDAC6))
pmid:25031639 a(HBP:"Tau epitope, 12E8") partOf p(HBP:"KXGS motif")
pmid:25031639 a(HBP:"Tau epitope, 12E8") negativeCorrelation act(p(HGNC:STUB1))
pmid:27574109 a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
pmid:27574109 a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
pmid:27574109 a(HBP:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization")
pmid:27574109 a(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27574109 a(HBP:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:27574109 a(HBP:"4R tau") positiveCorrelation a(HBP:"Corticobasal Degeneration")
pmid:27574109 a(HBP:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological")
pmid:27574109 a(HBP:"Tau isoform F (441 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:29686391 a(HBP:"Tau isoform F (441 aa)") positiveCorrelation tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau isoform F (441 aa)")
pmid:29686391 a(HBP:"Tau isoform F (441 aa)") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(CHEBI:heparin)
pmid:29686391 tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(HBP:"6-O-sulfated heparin")
pmid:27574109 bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"4R tau")
pmid:27574109 bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"3R tau")
pmid:27574109 a(HBP:"Tau isoform Fetal-tau (352 aa)") association a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform Fetal-tau (352 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform Fetal-tau (352 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform D (383 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform D (383 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform C (410 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform C (410 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation"))
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform B (381 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform F (441 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform E (412 aa)")
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(HBP:pretangles)
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage I")
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage II")
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles")
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(HBP:"Corticobasal Degeneration")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Corticobasal Degeneration")
pmid:27574109 a(HBP:"phosphatase-activating domain") association a(GO:"Pick body")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies)
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27574109 a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:27574109 a(HBP:"Tau isoform D (383 aa)") association a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Tau isoform C (410 aa)") association a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"retrograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport")
pmid:29191965 p(HBP:"Tau isoform Fetal-tau (352 aa)") decreases bp(GO:locomotion)
pmid:17493042 p(HBP:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain)
pmid:27574109 p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers")
pmid:27574109 p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport")
pmid:27574109 p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport")
pmid:27574109 a(HBP:"Tau isoform B (381 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Tau isoform E (412 aa)") increases a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Tau isoform E (412 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:pretangles) association a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:pretangles) association a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:pretangles) association p(HGNC:MAPT)
pmid:23407988 a(HBP:pretangles) increases complex(GO:"dendritic tree")
pmid:18239272 a(HBP:pretangles) association p(HGNC:TTBK1)
pmid:18239272 a(HBP:pretangles) association p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:18239272 a(HBP:pretangles) isA a(GO:"neurofibrillary tangle")
pmid:27574109 a(HBP:"Braak_Stage I") association a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Braak_Stage I") association a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Braak_Stage I") association p(HGNC:MAPT)
pmid:28176663 a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin))
pmid:27574109 a(HBP:"Corticobasal Degeneration") association a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers")
pmid:27574109 a(HBP:"Corticobasal Degeneration") association a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain")
pmid:27574109 a(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT)
pmid:27574109 a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT)
pmid:27574109 a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT)
pmid:27574109 a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau")
pmid:27574109 a(HBP:"Corticobasal Degeneration") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT))
pmid:27574109 composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:27574109 composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:27574109 composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation a(HBP:"Corticobasal Degeneration")
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") decreases bp(MESH:"Cell Survival")
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph))
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases p(RGD:Mapt, pmod(Ph))
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands"))
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:17403556 a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:18096814 a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft"))
pmid:18096814 a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft"))
pmid:20133804 p(RGD:Mapt, pmod(Ph)) positiveCorrelation p(RGD:Fkbp4)
pmid:17403556 a(HBP:"amyloid-beta antibody, NU1") decreases act(a(HBP:"amyloid-beta derived diffusible ligands"))
pmid:17403556 a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons))
pmid:17403556 a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons))
pmid:17403556 a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands"))
pmid:28420982 p(HGNC:MAPT, pmod(Ph, Thr, 181)) association a(MESH:Exosomes)
pmid:28420982 p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28420982 p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation p(FPLX:PKA)
pmid:11943212 p(HGNC:MAPT, pmod(Ph, Thr, 181)) partOf p(HBP:"Tau epitope, AT270")
pmid:28176663 p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation a(CHEBI:"D-ribose")
pmid:17403556 a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases bp(GO:"signal transduction")
pmid:17403556 a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:17403556 a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:17403556 a(CHEBI:LY294002) decreases bp(GO:"signal transduction")
pmid:17403556 a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:17403556 complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse))
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Axons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:neurogenesis)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation act(a(MESH:Microglia))
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Microglia)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(MESH:Microglia))
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange path(MESH:Inflammation)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment"))
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:"Stem Cells")
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation")
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases p(MGI:Wnt5a)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3)
pmid:27671637 a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))
pmid:27671637 a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Axons)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(GO:"dendritic spine")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:dendrite))
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons))
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons)
pmid:28528849 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress")
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1)
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse))
pmid:27671637 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission")
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau aggregates")
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse)
pmid:28528849 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(HBP:Neurodegeneration)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia))
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(MESH:Microglia)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia))
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Inflammation)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Hypertrophy)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment"))
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt)
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment"))
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(MESH:"Stem Cells")
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation")
pmid:29202785 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Hippocampus)
pmid:28528849 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:memory)
pmid:28528849 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau fibrils")
pmid:28528849 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau oligomers")
pmid:28528849 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases p(HBP:"Tau oligomers", var("p.Lys280del"))
pmid:28528849 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"reactive oxygen species")
pmid:28528849 p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange bp(GO:"cellular calcium ion homeostasis")
pmid:27671637 a(HP:"Argyrophilic inclusion bodies") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp)
pmid:27671637 p(MGI:Mapt, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt))
pmid:27671637 a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))
pmid:22833681 a(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:27671637 composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) negativeCorrelation bp(GO:"cellular protein catabolic process")
pmid:27671637 p(MGI:Fos) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 p(MGI:Fos) biomarkerFor act(a(MESH:Neurons))
pmid:27671637 p(MGI:Gfap) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation")
pmid:27671637 p(MGI:Hmox1) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
pmid:27671637 p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress")
pmid:27671637 a(CHEBI:adenosine) increases act(p(MGI:Adora1))
pmid:27671637 a(CHEBI:adenosine) decreases act(a(MESH:Neurons))
pmid:27671637 a(CHEBI:adenosine) decreases act(a(GO:presynapse))
pmid:27671637 a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation")
pmid:21882945 a(CHEBI:adenosine) decreases act(p(INTERPRO:"Heat shock protein 70 family"))
pmid:27671637 act(p(MGI:Adora1)) decreases act(a(MESH:Neurons))
pmid:27671637 act(p(MGI:Adora1)) decreases act(a(GO:presynapse))
pmid:27671637 act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation")
pmid:27671637 a(PUBCHEM:64627) decreases act(p(MGI:Adora1))
pmid:27671637 a(PUBCHEM:64627) increases act(a(MESH:Neurons))
pmid:27671637 a(PUBCHEM:64627) increases act(a(GO:presynapse))
pmid:27671637 a(PUBCHEM:64627) increases a(GO:"dendritic spine")
pmid:27671637 a(PUBCHEM:64627) decreases a(MESH:Axons)
pmid:27671637 a(MESH:"BSc 3094") decreases a(HBP:"Tau aggregates")
pmid:27671637 a(MESH:"BSc 3094") increases act(a(GO:presynapse))
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine")
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine")
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(GO:presynapse))
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(MESH:Neurons))
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases p(MGI:Fos)
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases path(MESH:"Spatial Memory")
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory")
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"associative learning")
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential")
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission")
pmid:27671637 composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine")
pmid:28784767 p(HGNC:MAPT, pmod(Ph, Ser, 208)) partOf p(HBP:"Tau epitope, AT8")
pmid:28784767 p(HGNC:MAPT, pmod(Ph, Ser, 208)) decreases a(HBP:"Tau Protein Secondary Structure, Turn")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28784767 p(HBP:"Tau epitope, AT8") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208))
pmid:28784767 p(HBP:"Tau epitope, AT8") increases a(HBP:"Tau aggregates")
pmid:18239272 p(HBP:"Tau epitope, AT8") association a(GO:"neurofibrillary tangle")
pmid:18239272 p(HBP:"Tau epitope, AT8") association a(MESH:"Neuropil Threads")
pmid:18239272 p(HBP:"Tau epitope, AT8") association path(MESH:"Plaque, Amyloid")
pmid:28784767 p(HBP:"Tau epitope, AT8") increases bp(HBP:"Tau aggregates")
pmid:27087442 p(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"CDK5R1 p25")
pmid:25125464 p(HBP:"Tau epitope, AT8") positiveCorrelation p(MGI:Crhr1)
pmid:19459590 p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:MAPT))
pmid:19459590 p(HBP:"Tau epitope, AT8") decreases act(p(HGNC:MAPT))
pmid:22833681 p(HBP:"Tau epitope, AT8") increases complex(p(HGNC:FYN), p(MGI:Mapt))
pmid:22253473 p(HBP:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil)
pmid:20869593 p(HBP:"Tau epitope, AT8") positiveCorrelation p(HGNC:MAPT, pmod(Ac))
pmid:20869593 p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:SIRT1))
pmid:19623258 p(HBP:"Tau epitope, AT8") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex"))
pmid:28784767 p(HGNC:MAPT, var("pGly207Val")) increases a(HBP:"Tau aggregates")
pmid:28784767 p(HGNC:MAPT, var("pGly207Val")) increases bp(HBP:"Tau aggregates")
pmid:28784767 a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates")
pmid:28784767 a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates")
pmid:28784767 a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates")
pmid:28784767 a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates")
pmid:28784767 p(HGNC:MAPT, var("p.Gly207Val")) decreases a(HBP:"Tau Protein Secondary Structure, Turn")
pmid:28784767 act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208))
pmid:25673844 p(FPLX:CSNK1) isA p(HBP:"CK1 superfamily")
pmid:25673844 p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42))
pmid:25673844 p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45))
pmid:25673844 p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47))
pmid:25673844 p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80))
pmid:25673844 p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81))
pmid:25673844 p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84))
pmid:28784767 p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) equivalentTo p(HBP:"Tau epitope, AT8")
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia")
pmid:24406748 p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia")
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body"))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body"))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body"))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body"))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"early endosome")
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome")
pmid:29590627 p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:lysosome)
pmid:28877763 p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:28877763 p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:28877763 p(HGNC:MAPT, var("p.Pro301Ser")) increases a(HBP:"Tau aggregates")
pmid:24406748 p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:24406748 p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:24406748 p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport")
pmid:24406748 p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition)
pmid:29590627 a(CHEBI:dextran) increases tloc(a(CHEBI:dextran))
pmid:28420982 a(CHEBI:dextran) association a(HBP:"Tau aggregates")
pmid:29590627 a(CHEBI:heparin) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 a(CHEBI:heparin) causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:25887395 a(CHEBI:heparin) decreases a(HBP:"Tau aggregates")
pmid:29988016 a(CHEBI:heparin) increases a(HBP:"Tau aggregates")
pmid:25887395 a(CHEBI:heparin) decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans))
pmid:29988016 a(CHEBI:heparin) increases p(HGNC:MAPT, var("?"))
pmid:29686391 a(CHEBI:heparin) association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(CHEBI:heparin) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:26751493 a(CHEBI:heparin) association p(HBP:"Tau aggregates")
pmid:27601475 a(CHEBI:heparin) increases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:heparin) partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates"))
pmid:29590627 a(CHEBI:dynasore) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29686391 a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29590627 a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization")
pmid:29590627 a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis")
pmid:29590627 a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis)
pmid:29590627 a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:"bulk synaptic vesicle endocytosis")
pmid:29590627 bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:macropinocytosis)
pmid:29590627 bp(GO:"actin filament polymerization") increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:24760868 bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin")
pmid:27041503 bp(GO:"actin filament polymerization") negativeCorrelation bp(MESH:"Long-Term Potentiation")
pmid:29590627 bp(GO:macropinocytosis) negativeCorrelation a(CHEBI:"cytochalasin D")
pmid:29590627 bp(GO:macropinocytosis) positiveCorrelation bp(GO:"actin filament polymerization")
pmid:26751493 bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(HBP:"Tau aggregates"))
pmid:26751493 bp(GO:macropinocytosis) isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons))
pmid:29590627 composite(a(CHEBI:dynasore), p(HGNC:MAPT, var("p.Pro301Ser"))) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:29590627 composite(a(CHEBI:"cytochalasin D"), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons))
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates")
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(Ph))
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:locomotion)
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development")
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development")
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development")
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development")
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) increases path(HBP:neurotoxicity)
pmid:22611162 p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"nervous system development")
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) decreases p(HBP:"4R tau")
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) increases p(HBP:"3R tau")
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) increases bp(GO:memory)
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment"))
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) increases a(GO:"neurofibrillary tangle")
pmid:26631930 p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:cognition)
pmid:11606569 p(HGNC:MAPT, var("p.Lys280del")) equivalentTo g(DBSNP:rs63750688)
pmid:11606569 p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIINK motif")
pmid:11606569 p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIVYK motif")
pmid:22611162 p(HGNC:MAPT, var("p.Ile277Pro")) decreases a(HBP:"Tau aggregates")
pmid:22611162 p(HGNC:MAPT, var("p.Ile308Pro")) decreases a(HBP:"Tau aggregates")
pmid:22611162 p(HGNC:MAPT, var("p.Val277Met")) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:22611162 p(HGNC:MAPT, var("p.Val277Met")) increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:22611162 p(HGNC:MAPT, var("p.Val277Met")) increases path(HBP:neurotoxicity)
pmid:22611162 p(HGNC:MAPT, var("p.Val277Met")) decreases bp(GO:"nervous system development")
pmid:22611162 a(PUBCHEM:25096749) increases bp(GO:locomotion)
pmid:22611162 a(PUBCHEM:25096749) decreases a(HBP:"Tau aggregates")
pmid:22611162 a(HBP:bb14) increases bp(GO:locomotion)
pmid:22611162 a(HBP:cmp16) decreases a(HBP:"Tau fibrils")
pmid:22611162 a(HBP:cmp16) increases bp(GO:locomotion)
pmid:22611162 a(HBP:cmp16) decreases bp(HP:Neurodegeneration)
pmid:24760868 p(MESH:Actins, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:24760868 p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation")
pmid:24760868 complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) association bp(GO:"long-term synaptic potentiation")
pmid:17187063 complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:Neurodegeneration)
pmid:24760868 a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization")
pmid:24760868 a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization")
pmid:24760868 a(MESH:jasplakinolide) increases p(HGNC:MAPT)
pmid:24760868 a(MESH:jasplakinolide) increases p(HGNC:GRIA1)
pmid:24760868 a(MESH:jasplakinolide) decreases p(HGNC:FYN)
pmid:24760868 a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization")
pmid:24760868 a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization")
pmid:24760868 a(CHEBI:"latrunculin A") decreases p(HGNC:MAPT)
pmid:24760868 complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) association a(MESH:"Dendritic Spines")
pmid:29202785 a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))
pmid:29202785 a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))
pmid:29202785 a(CHEBI:doxycycline) decreases p(MGI:Wnt5a)
pmid:29202785 a(CHEBI:doxycycline) decreases p(MGI:Wnt3)
pmid:21734277 p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"6D tau") causesNoChange bp(GO:"retrograde axonal protein transport")
pmid:21734277 p(HBP:"6D tau") increases act(p(MESH:"Protein Phosphatase 1"))
pmid:21734277 p(HBP:"6D tau") increases act(p(MESH:"Glycogen Synthase Kinase 3"))
pmid:21734277 act(p(HBP:"6D tau")) association p(HBP:"6D tau", frag("2_18"))
pmid:21734277 p(HBP:"6P tau") decreases bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"6P tau") causesNoChange bp(GO:"retrograde axonal protein transport")
pmid:21734277 act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport")
pmid:21734277 act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"6D tau", frag("2_18")) association act(p(HBP:"6D tau"))
pmid:21734277 p(HBP:"6D tau", frag("2_18")) association bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"6D tau", frag("2_18")) causesNoChange bp(GO:"retrograde axonal protein transport")
pmid:21734277 p(HBP:"6D tau", frag("2_18")) decreases p(HBP:"endogenous axoplasmic phosphatases")
pmid:21734277 p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3"))
pmid:21734277 p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3"))
pmid:21734277 p(HBP:"6D tau", frag("2_18")) association p(HBP:TNT1)
pmid:21734277 act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease")
pmid:21734277 act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease")
pmid:21734277 a(HBP:"I-2") increases act(p(HBP:"6D tau", frag("2_18")))
pmid:21734277 a(HBP:"ING-135") increases act(p(HBP:"6D tau", frag("2_18")))
pmid:21734277 p(HBP:"AT8 tau") decreases bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"AT8 tau") causesNoChange bp(GO:"retrograde axonal protein transport")
pmid:21734277 p(HBP:"AT8 tau") causesNoChange act(p(HBP:"6D tau", frag("2_18")))
pmid:21734277 p(HBP:"AT8 tau", pmod(Ph)) association p(HGNC:MAPT, pmod(Ph))
pmid:21734277 p(HBP:"AT8 tau", pmod(Ph)) association path(MESH:Tauopathies)
pmid:21734277 p(HBP:"delta 144-273 tau") decreases bp(GO:"anterograde axonal protein transport")
pmid:21734277 p(HBP:"delta 144-273 tau") causesNoChange bp(GO:"retrograde axonal protein transport")
pmid:21734277 p(HBP:TNT1) association p(HBP:"6D tau", frag("2_18"))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HBP:"Tau fibrils", var("p.Lys280del"))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cell death")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange bp(GO:"cell death")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"apoptotic process")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"negative regulation of mitochondrial membrane potential")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP3))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP7))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases sec(p(HGNC:CYCS))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange a(GO:membrane)
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:postsynapse)
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:GRIA1)
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:DBN1)
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:SYP)
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HGNC:NOX1)
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex"))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex"))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:CYBB)
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cellular calcium ion homeostasis")
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body"))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines"))
pmid:28528849 p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:synapse)
pmid:29238289 p(HBP:"Tau fibrils") increases tloc(p(HGNC:MAPT))
pmid:23702978 tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome))
pmid:23702978 tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS))
pmid:28528849 p(HGNC:DBN1) increases bp(GO:"synapse assembly")
pmid:28528849 act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species")
pmid:28528849 act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species")
pmid:23528736 p(HGNC:UBB) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23528736 p(HGNC:UBC) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23528736 p(HGNC:UBA52) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23528736 p(HGNC:RPS27A) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23528736 p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:23528736 p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:23528736 p(HGNC:RNF182) association path(MESH:"Neurodegenerative Diseases")
pmid:23528736 composite(p(HGNC:HSPA8), p(HGNC:STUB1), p(HGNC:UBE2D2)) increases deg(p(HGNC:MAPT))
pmid:14612456 p(HGNC:UBE2D2) positiveCorrelation p(HGNC:MAPT, pmod(Ub))
pmid:14612456 p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2))
pmid:23528736 a(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome))
pmid:23528736 a(CHEBI:"lithium atom") increases bp(GO:autophagy)
pmid:23528736 a(CHEBI:"lithium atom") decreases p(HGNC:MAPT)
pmid:23528736 a(CHEBI:"lithium atom") decreases a(HP:"Neurofibrillary tangles")
pmid:30108137 r(HGNC:TFEB) positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:30108137 p(MGI:Tfeb) increases p(MGI:Lamp1)
pmid:30108137 p(MGI:Tfeb) increases p(MGI:Ctsa)
pmid:30108137 p(MGI:Tfeb) increases p(MGI:Ctsb)
pmid:30108137 p(MGI:Tfeb) regulates act(a(MESH:Lysosomes))
pmid:30108137 p(MGI:Tfeb) increases act(a(MESH:Phagocytes))
pmid:30108137 p(MGI:Tfeb) increases a(HBP:"Tau fibrils")
pmid:30108137 p(MGI:Tfeb) increases a(HBP:"Tau fibrils")
pmid:30108137 p(MGI:Tfeb) increases a(HBP:"Tau fibrils")
pmid:30108137 p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils"))
pmid:30108137 p(MGI:Tfeb) increases bp(MESH:Phagocytosis)
pmid:30108137 p(MGI:Tfeb) increases r(MGI:Lamp1)
pmid:30108137 p(MGI:Tfeb) increases bp(MESH:Proteolysis)
pmid:30108137 p(MGI:Tfeb) causesNoChange p(MGI:Phf1)
pmid:30108137 p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph))
pmid:30108137 p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph))
pmid:30108137 p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(Ph))
pmid:30108137 p(MGI:Tfeb) decreases p(MGI:Mapt)
pmid:30108137 p(MGI:Tfeb) decreases path(MESH:Tauopathies)
pmid:30108137 p(MGI:Tfeb) decreases path(MESH:Gliosis)
pmid:30108137 bp(MESH:Pinocytosis) increases act(a(MESH:Astrocytes))
pmid:25887395 p(HGNC:MAPT, frag("243_375")) increases a(HBP:"Tau fibrils")
pmid:25887395 complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:25887395 complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases a(HBP:"Tau aggregates")
pmid:25887395 a(CHEBI:"sodium chlorate") decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans))
pmid:25887395 a(CHEBI:"sodium chlorate") decreases a(HBP:"Tau aggregates")
pmid:25887395 complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:25887395 complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates")
pmid:25887395 complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates")
pmid:29988016 p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT))
pmid:22817713 complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers")
pmid:29988016 a(PUBCHEM:100984821) increases a(HBP:"Tau aggregates")
pmid:21882945 a(PUBCHEM:134222899) positiveCorrelation bp(GO:cognition)
pmid:21882945 a(CHEBI:rhodanine) decreases a(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:rhodanine) decreases p(HBP:"Tau aggregates")
pmid:21882945 a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates")
pmid:29191965 a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates")
pmid:29191965 a(HBP:"Phenylthiazolyl-hydrazide") positiveCorrelation bp(GO:locomotion)
pmid:21882945 a(PUBCHEM:53789478) decreases a(HBP:"Tau aggregates")
pmid:21882945 a(CHEBI:anthraquinone) decreases a(HBP:"Tau aggregates")
pmid:21882945 a(CHEBI:benzothiazoles) decreases a(HBP:"Tau aggregates")
pmid:21882945 a(CHEBI:phenothiazines) decreases a(HBP:"Tau aggregates")
pmid:21882945 a(CHEBI:polyphenol) decreases a(HBP:"Tau aggregates")
pmid:21882945 a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 p(INTERPRO:"Chaperone J-domain superfamily") increases act(p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 p(INTERPRO:"Chaperone J-domain superfamily") increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP)))
pmid:21882945 a(MESH:"Guanine Nucleotide Exchange Factors") increases act(p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 a(MESH:"Guanine Nucleotide Exchange Factors") increases a(CHEBI:ADP)
pmid:21882945 a(PUBCHEM:25195348) decreases act(a(MESH:"Adenosine Triphosphatases"))
pmid:21882945 a(PUBCHEM:1056) decreases act(p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 a(PUBCHEM:6444403) decreases act(p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 complex(p(FPLX:HSP90), p(FPLX:HSP90)) increases act(p(FPLX:HSP90))
pmid:21882945 p(INTERPRO:"Tetratricopeptide repeat-containing domain") regulates act(p(FPLX:HSP90))
pmid:21882945 a(PUBCHEM:9549213) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal"))
pmid:21882945 a(PUBCHEM:9549213) directlyDecreases act(p(FPLX:HSP90))
pmid:21882945 a(CHEBI:novobiocin) directlyIncreases complex(a(CHEBI:novobiocin), p(INTERPRO:"HSP90, C-terminal domain"))
pmid:21882945 a(CHEBI:novobiocin) directlyDecreases act(p(FPLX:HSP90))
pmid:21882945 a(PUBCHEM:501026) directlyIncreases complex(a(PUBCHEM:501026), p(INTERPRO:"HSP90, C-terminal domain"))
pmid:21882945 a(PUBCHEM:501026) directlyDecreases act(p(FPLX:HSP90))
pmid:21882945 a(CHEBI:celastrol) association act(p(FPLX:HSP90))
pmid:29311797 a(CHEBI:celastrol) decreases act(p(FPLX:HSP90))
pmid:29311797 a(CHEBI:celastrol) decreases p(HGNC:MAPT)
pmid:21882945 complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:21882945 complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:14963027 complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:14963027 complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT)))
pmid:21882945 complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT)
pmid:20071522 complex(p(FPLX:HSP90), p(HGNC:MAPT)) positiveCorrelation p(HGNC:FKBP5)
pmid:20071522 complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:20071522 complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:20071522 complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:21882945 complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT))
pmid:21882945 complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:29311797 complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(HBP:"Tau aggregates")
pmid:21882945 complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:21882945 complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family"))
pmid:21882945 complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases bp(GO:"protein polyubiquitination")
pmid:21882945 complex(a(MESH:Proteins), p(FPLX:HSP90)) increases deg(a(MESH:Proteins))
pmid:21882945 complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL))
pmid:21882945 complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL))
pmid:21882945 complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL))
pmid:30126037 bp(GO:"cellular senescence") association bp(GO:"cell cycle")
pmid:30126037 bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival")
pmid:30126037 bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival")
pmid:30126037 bp(GO:"cellular senescence") association bp(MESH:"Cell Survival")
pmid:30126037 bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling")
pmid:30126037 bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling")
pmid:30126037 bp(GO:"cellular senescence") decreases bp(GO:"metabolic process")
pmid:30126037 bp(GO:"cellular senescence") decreases bp(GO:"metabolic process")
pmid:30126037 bp(GO:"cellular senescence") association p(MGI:Cdkn2a)
pmid:30126037 bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle")
pmid:30126037 bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle")
pmid:30126037 bp(GO:"cellular senescence") increases bp(GO:"neuron death")
pmid:30126037 bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular")
pmid:30126037 bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular")
pmid:30126037 bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration)
pmid:30126037 bp(GO:"cellular senescence") association path(MESH:Tauopathies)
pmid:30126037 bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest")
pmid:30126037 bp(GO:"cellular senescence") decreases sec(a(MESH:Immunotoxins))
pmid:30126037 bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage")
pmid:30126037 bp(GO:"cellular senescence") association bp(MESH:"DNA Damage")
pmid:30126037 bp(GO:"cellular senescence") increases p(MGI:Cdkn1a)
pmid:30126037 bp(GO:"cellular senescence") increases p(HGNC:CDKN2A)
pmid:30126037 bp(GO:"cellular senescence") association bp(GO:"inflammatory response")
pmid:30126037 bp(GO:"cellular senescence") increases bp(HBP:HBP00037)
pmid:29221819 bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a)
pmid:30126037 p(MGI:Cdkn2a) association bp(GO:"cellular senescence")
pmid:30126037 p(MGI:Cdkn2a) positiveCorrelation path(HP:"Cerebral atrophy")
pmid:30126037 p(MGI:Cdkn2a) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:30126037 p(MGI:Cdkn2a) positiveCorrelation path(HP:"Brain atrophy")
pmid:30126037 path(HP:"Cerebral atrophy") positiveCorrelation p(MGI:Cdkn2a)
pmid:30126037 path(MESH:"Hypertrophy, Right Ventricular") association a(GO:"neurofibrillary tangle")
pmid:30126037 path(MESH:"Hypertrophy, Left Ventricular") association a(GO:"neurofibrillary tangle")
pmid:30126037 bp(MESH:"DNA Damage") association bp(GO:"cellular senescence")
pmid:30126037 p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded")
pmid:30126037 p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence")
pmid:30126037 p(MGI:Glb1) positiveCorrelation a(HP:brain)
pmid:30126037 a(HP:brain) positiveCorrelation p(MGI:Glb1)
pmid:30126037 bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport")
pmid:30126037 path(HP:"Brain atrophy") positiveCorrelation p(MGI:Cdkn2a)
pmid:30126037 path(HP:"Brain atrophy") association a(GO:"neurofibrillary tangle")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation")
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp)
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3)
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4)
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1)
pmid:30126037 composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection)
pmid:30126037 path(MESH:"Cerebral Small Vessel Diseases") increases path(HP:"Hyperintensity of cerebral white matter on MRI")
pmid:30126037 path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia)
pmid:30126037 path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:"Cognitive Dysfunction")
pmid:30126037 path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia)
pmid:28408124 a(HBP:"Tau antibody, Tau-13") decreases p(MGI:Mapt, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, Tau-13") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, Tau-13") decreases p(HGNC:MAPT, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, Tau-13") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, 6C5") decreases p(MGI:Mapt, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, 6C5") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT)
pmid:28408124 a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, HT7") decreases p(MGI:Mapt, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, HT7") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, HT7") decreases p(HGNC:MAPT, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, HT7") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, 40E8") decreases p(MGI:Mapt, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, 40E8") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT)
pmid:28408124 a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, pmod(Ph))
pmid:28408124 a(HBP:"Tau antibody, pS396") decreases p(MGI:Mapt, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, pS396") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, pS396") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, pmod(Ph))
pmid:28408124 a(HBP:"Tau antibody, 4E4") decreases p(MGI:Mapt, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, 4E4") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, 4E4") decreases p(HGNC:MAPT, loc(GO:cell))
pmid:28408124 a(HBP:"Tau antibody, 4E4") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, Tau46") causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:28408124 a(HBP:"Tau antibody, Tau46") association p(HGNC:MAPT)
pmid:25331948 a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta")
pmid:25331948 a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta")
pmid:25331948 a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta")
pmid:25331948 a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta")
pmid:25331948 a(CHEBI:Nilvadipine) decreases act(p(HGNC:APP))
pmid:25331948 a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta"))
pmid:25331948 a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta"))
pmid:25331948 a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1)
pmid:25331948 a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1)
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1)
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1)
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1)
pmid:25331948 a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25331948 a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma))
pmid:25331948 a(CHEBI:Nilvadipine) increases bp(GO:"amyloid-beta clearance by transcytosis")
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 199))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 202))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Thr, 205))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 404))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:RAF1, pmod(Ph))
pmid:25331948 a(CHEBI:Nilvadipine) decreases act(p(HGNC:SYK))
pmid:25331948 a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK))
pmid:25331948 a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK))
pmid:25331948 a(CHEBI:Nilvadipine) decreases act(complex(GO:"NF-kappaB complex"))
pmid:25331948 a(CHEBI:Nilvadipine) directlyDecreases complex(GO:"L-type voltage-gated calcium channel complex")
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:25331948 a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:29221819 p(MGI:Mapt, pmod(Ph, Ser, 202)) negativeCorrelation p(MGI:Dyrk1a)
pmid:25331948 p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Syk)
pmid:26095350 p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose")
pmid:28877763 p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk)
pmid:25331948 p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk)
pmid:28877763 p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk)
pmid:25331948 p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk)
pmid:25331948 composite(a(CHEBI:Nilvadipine), p(HGNC:TNF)) decreases act(complex(GO:"NF-kappaB complex"))
pmid:25331948 composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex"))
pmid:25331948 a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(FPLX:PKC))
pmid:25331948 a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(complex(GO:"NF-kappaB complex"))
pmid:25331948 a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph))
pmid:25331948 a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph))
pmid:25331948 a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:SYK))
pmid:25331948 a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:BTK))
pmid:25331948 composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(p(HGNC:TNF))
pmid:25331948 composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(complex(GO:"NF-kappaB complex"))
pmid:25331948 act(p(HGNC:SYK)) regulates act(complex(GO:"NF-kappaB complex"))
pmid:25331948 p(HGNC:SYK) increases act(complex(GO:"NF-kappaB complex"))
pmid:25331948 p(HGNC:SYK) regulates act(complex(GO:"NF-kappaB complex"))
pmid:25331948 p(HGNC:SYK) increases a(CHEBI:"amyloid-beta")
pmid:25331948 act(p(HGNC:SYK)) increases a(CHEBI:"amyloid-beta")
pmid:25331948 act(p(HGNC:SYK)) decreases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma))
pmid:25331948 act(p(HGNC:SYK)) increases sec(p(HBP:"sAPP-beta"))
pmid:28877763 p(HGNC:SYK) regulates p(HBP:"sAPP-beta")
pmid:25331948 act(p(HGNC:SYK)) increases r(HGNC:BACE1)
pmid:25331948 act(p(HGNC:SYK)) increases p(HGNC:BACE1)
pmid:28877763 p(HGNC:SYK) regulates p(HGNC:BACE1)
pmid:25331948 act(p(HGNC:SYK)) increases p(HGNC:RAF1, pmod(Ph))
pmid:25331948 p(HGNC:SYK) regulates p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:28877763 p(HGNC:SYK) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:28877763 act(p(HGNC:SYK), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:28877763 act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:28877763 p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:28877763 act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:26631930 p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:25331948 act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B))
pmid:28877763 p(HGNC:SYK) increases act(p(HGNC:GSK3B))
pmid:25331948 act(p(HGNC:SYK)) positiveCorrelation act(p(HGNC:GSK3B), ma(kin))
pmid:25331948 p(HGNC:SYK) decreases act(p(FPLX:PKA))
pmid:25331948 p(HGNC:SYK) decreases act(p(FPLX:PKA))
pmid:25331948 p(HGNC:SYK) increases p(FPLX:PKA, pmod(Ph, Tyr, 330))
pmid:29191965 p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr))
pmid:28877763 act(p(HGNC:SYK)) positiveCorrelation bp(GO:"microglial cell activation")
pmid:28877763 act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates")
pmid:28877763 act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates")
pmid:28877763 act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates")
pmid:28877763 p(HGNC:SYK) association a(HBP:"Tau aggregates")
pmid:28877763 p(HGNC:SYK) association a(HBP:"Tau aggregates")
pmid:28877763 p(HGNC:SYK) positiveCorrelation a(HBP:"Tau aggregates")
pmid:28877763 act(p(HGNC:SYK)) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:28877763 act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
pmid:28877763 p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
pmid:28877763 act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:28877763 act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(HBP:misfolded))
pmid:28877763 act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:misfolded))
pmid:28877763 p(HGNC:SYK) increases p(HGNC:MAPT)
pmid:28877763 p(HGNC:SYK) causesNoChange r(HGNC:MAPT)
pmid:26501932 p(HGNC:SYK) partOf a(HBP:pretangles)
pmid:26501932 p(HGNC:SYK) partOf a(HBP:"GVD bodies")
pmid:25331948 act(p(HGNC:SYK)) negativeCorrelation p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:23702978 act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1))
pmid:25331948 act(p(HGNC:BTK)) regulates act(complex(GO:"NF-kappaB complex"))
pmid:25331948 a(PUBCHEM:71656932) decreases act(p(HGNC:BTK))
pmid:25331948 a(PUBCHEM:71656932) causesNoChange a(CHEBI:"amyloid-beta")
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(complex(GO:"NF-kappaB complex"))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta")
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases sec(p(HBP:"sAPP-beta"))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases r(HGNC:BACE1)
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:BACE1)
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:App, frag("1_38"))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Tyr, 18))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 404))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 202))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(MGI:Mapt, pmod(Ph, Tyr, 231))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(HGNC:MAPT, pmod(Ph, Tyr, 231))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(FPLX:AKT, pmod(Ph, Ser, 473))
pmid:25331948 a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:CREB1, pmod(Ph))
pmid:28877763 p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK)
pmid:28877763 p(HGNC:MAPT, pmod(Ph, Tyr, 18)) increases act(p(HGNC:SYK))
pmid:28877763 p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation act(p(HGNC:SYK))
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Tyr, 18)) association a(HBP:"paired helical filaments")
pmid:28877763 p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph))
pmid:28877763 p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk)
pmid:25331948 p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk)
pmid:25331948 p(FPLX:PKA, pmod(Ph, Tyr, 330)) decreases act(p(FPLX:PKA))
pmid:22419736 p(HGNC:AK1) positiveCorrelation p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T"))
pmid:22419736 p(HGNC:AK1) positiveCorrelation p(HGNC:APP)
pmid:22419736 p(HGNC:AK1) decreases act(a(CHEBI:"amyloid-beta polypeptide 42"))
pmid:22419736 act(p(HGNC:AK1)) association a(CHEBI:"amyloid-beta polypeptide 42")
pmid:22419736 p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 202)))
pmid:22419736 p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 396)))
pmid:22419736 p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 404)))
pmid:22419736 p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 231)))
pmid:22419736 p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 235)))
pmid:22419736 p(HGNC:AK1) increases p(HBP:"Tau aggregates")
pmid:22419736 p(HGNC:AK1) increases p(HGNC:MAPT, pmod(Ph))
pmid:22419736 p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:22419736 p(HGNC:AK1) regulates p(ECCODE:"2.7.11.31")
pmid:22419736 p(HGNC:AK1) regulates p(HGNC:GSK3B)
pmid:22419736 p(HGNC:AK1) increases path(MESH:"Retinal Degeneration")
pmid:22419736 p(HGNC:AK1) increases path(MESH:"Retinal Degeneration")
pmid:22419736 p(HGNC:AK1) increases act(p(HGNC:MAPT))
pmid:22419736 p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(HGNC:AK1)
pmid:22419736 act(p(ECCODE:"2.7.11.31")) negativeCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 396))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 396))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases act(p(HGNC:GSK3B))
pmid:22419736 p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph))
pmid:22419736 p(HBP:"AK1 R132A") causesNoChange p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172))
pmid:22419736 a(HBP:acadesine) increases act(p(ECCODE:"2.7.11.31"))
pmid:22419736 path(MESH:"Retinal Degeneration") association p(HGNC:MAPT, pmod(Ph))
pmid:30640040 act(p(HGNC:FLT1)) increases a(HBP:"Tau aggregates")
pmid:30640040 act(p(HGNC:KDR)) increases a(HBP:"Tau aggregates")
pmid:30640040 p(HGNC:KDR) association a(PUBCHEM:11154925)
pmid:30640040 p(HGNC:KDR) association a(PUBCHEM:11234052)
pmid:30640040 act(p(FPLX:TGFB)) increases a(HBP:"Tau aggregates")
pmid:30640040 act(p(FPLX:HDAC)) decreases a(HBP:"Tau aggregates")
pmid:30640040 p(FPLX:HDAC) association a(PUBCHEM:9865515)
pmid:21427723 act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(Ac))
pmid:30640040 a(PUBCHEM:9804992) decreases act(p(FPLX:HDAC))
pmid:30640040 a(PUBCHEM:9804992) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:9865515) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:9865515) association p(FPLX:HDAC)
pmid:30640040 a(PUBCHEM:4261) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:4261) association p(HGNC:HDAC1)
pmid:30640040 a(PUBCHEM:4261) association p(HGNC:HDAC3)
pmid:30640040 a(PUBCHEM:24756910) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:24756910) association p(FPLX:"HDAC_I")
pmid:30640040 a(PUBCHEM:24756910) association p(FPLX:"HDAC_II")
pmid:30640040 a(PUBCHEM:24756910) association p(HGNC:EGFR)
pmid:30640040 a(PUBCHEM:24756910) association p(HGNC:ERBB2)
pmid:30640040 a(PUBCHEM:448537) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:448537) association p(FPLX:ESR)
pmid:30640040 a(PUBCHEM:5318517) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:5318517) association p(FPLX:NFkappaB)
pmid:30640040 a(PUBCHEM:5318517) association p(FPLX:Actin)
pmid:30640040 a(PUBCHEM:71295844) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:71295844) association p(HGNC:GSK3A)
pmid:30640040 a(PUBCHEM:71295844) association p(HGNC:GSK3B)
pmid:30640040 a(PUBCHEM:42640) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:42640) association p(HGNC:MDM4)
pmid:30640040 a(PUBCHEM:2746) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:2746) association p(FPLX:"HDAC_I")
pmid:30640040 a(PUBCHEM:71729974) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:71729974) association p(HGNCGENEFAMILY:"Lysine demethylases")
pmid:30640040 a(PUBCHEM:53340666) increases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:53340666) association p(HGNC:HDAC6)
pmid:30640040 a(PUBCHEM:11154925) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:11154925) association p(HGNC:KDR)
pmid:30640040 a(PUBCHEM:4521392) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:4521392) association p(HGNC:TGFBR1)
pmid:30640040 a(PUBCHEM:11234052) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:11234052) association p(HGNC:KDR)
pmid:30640040 a(PUBCHEM:46209426) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:46209426) association p(FPLX:ROCK)
pmid:30640040 a(PUBCHEM:6321424) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:6321424) increases act(p(HGNCGENEFAMILY:"Chloride channel accessory"))
pmid:30640040 a(PUBCHEM:11570805) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:11570805) association p(HGNC:MAPK14)
pmid:30640040 a(PUBCHEM:156422) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:156422) association p(HGNC:MAPK14)
pmid:30640040 a(PUBCHEM:9880) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:9880) decreases act(p(HGNC:AR))
pmid:30640040 a(PUBCHEM:3033825) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:3033825) association p(HGNC:TNC)
pmid:30640040 a(PUBCHEM:5311272) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:5311272) decreases act(p(FPLX:"Gamma_secretase"))
pmid:30640040 a(PUBCHEM:49806720) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:49806720) decreases act(p(HGNC:ALK))
pmid:30640040 a(PUBCHEM:9839311) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:9839311) association p(HGNC:SELE)
pmid:30640040 a(PUBCHEM:9839311) association p(HGNC:ICAM1)
pmid:30640040 a(PUBCHEM:447966) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:447966) association p(HGNC:TGFBR1)
pmid:30640040 a(PUBCHEM:11655119) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:11655119) association p(HGNC:TGFBR1)
pmid:30640040 a(PUBCHEM:11655119) association p(HGNC:TGFBR2)
pmid:30640040 a(PUBCHEM:10435235) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:10435235) decreases act(p(FPLX:"Gamma_secretase"))
pmid:30640040 a(PUBCHEM:5833) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:5833) association p(HGNC:AR)
pmid:30640040 a(PUBCHEM:10341154) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:10341154) association p(HGNC:MAPK14)
pmid:30640040 a(PUBCHEM:4878) decreases a(HBP:"Tau aggregates")
pmid:30640040 a(PUBCHEM:4878) association p(HGNC:LCK)
pmid:30640040 a(PUBCHEM:4878) association p(HGNC:FYN)
pmid:30640040 p(HGNC:HDAC1) association a(PUBCHEM:4261)
pmid:30640040 p(HGNC:HDAC3) association a(PUBCHEM:4261)
pmid:28771976 p(HGNC:HDAC3) increases act(a(CL:0000129))
pmid:28771976 p(HGNC:HDAC3) increases a(CHEBI:"amyloid-beta")
pmid:28771976 p(HGNC:HDAC3) decreases a(GO:"dendritic spine")
pmid:30640040 p(FPLX:"HDAC_I") association a(PUBCHEM:24756910)
pmid:30640040 p(FPLX:"HDAC_I") association a(PUBCHEM:2746)
pmid:30640040 p(FPLX:"HDAC_II") association a(PUBCHEM:24756910)
pmid:30640040 p(HGNC:ERBB2) association a(PUBCHEM:24756910)
pmid:30640040 p(FPLX:ESR) association a(PUBCHEM:448537)
pmid:30640040 p(FPLX:Actin) association a(PUBCHEM:5318517)
pmid:22033876 act(p(FPLX:Actin)) association a(HBP:"proline-rich domain")
pmid:30640040 p(HGNC:MDM4) association a(PUBCHEM:42640)
pmid:30640040 p(HGNCGENEFAMILY:"Lysine demethylases") association a(PUBCHEM:71729974)
pmid:30640040 p(HGNC:TGFBR1) association a(PUBCHEM:4521392)
pmid:30640040 p(HGNC:TGFBR1) association a(PUBCHEM:447966)
pmid:30640040 p(HGNC:TGFBR1) association a(PUBCHEM:11655119)
pmid:30640040 p(FPLX:ROCK) association a(PUBCHEM:46209426)
pmid:30640040 p(HGNC:TNC) association a(PUBCHEM:3033825)
pmid:30640040 p(HGNC:SELE) association a(PUBCHEM:9839311)
pmid:30640040 p(HGNC:ICAM1) association a(PUBCHEM:9839311)
pmid:30640040 p(HGNC:TGFBR2) association a(PUBCHEM:11655119)
pmid:29191965 composite(a(MESH:"Amyloid beta-Peptides"), a(PUBCHEM:160718443)) decreases path(MESH:Paralysis)
pmid:29191965 bp(GO:"cellular response to mechanical stimulus") decreases a(GO:"microtubule cytoskeleton")
pmid:29191965 composite(p(HGNC:MAPT), p(HGNC:SPTB)) regulates a(GO:"microtubule cytoskeleton")
pmid:29191965 complex(p(HGNC:KLC3), p(HGNC:MAPT)) association a(GO:"synaptic vesicle")
pmid:29191965 p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases bp(GO:locomotion)
pmid:29191965 p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases a(MESH:Survival)
pmid:29191965 p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases path(HBP:Neurodegeneration)
pmid:29191965 p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases bp(GO:locomotion)
pmid:29191965 p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases a(MESH:Survival)
pmid:29191965 p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) increases path(HBP:Neurodegeneration)
pmid:29191965 p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons))
pmid:29191965 p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons))
pmid:29191965 p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases a(GO:microtubule)
pmid:29191965 p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases bp(GO:"neuron death")
pmid:29191965 p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons))
pmid:29191965 p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons))
pmid:29191965 p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases a(GO:microtubule)
pmid:29191965 p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) increases bp(GO:"neuron death")
pmid:29191965 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases bp(GO:locomotion)
pmid:29191965 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases a(MESH:"Motor Neurons")
pmid:29191965 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases path(MESH:Paralysis)
pmid:29191965 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"GABAergic Neurons")
pmid:29191965 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"Cholinergic Neurons")
pmid:29191965 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(GO:synapse)
pmid:29191965 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases bp(GO:"axonal transport of mitochondrion")
pmid:25374103 p(HBP:"4R tau", var("p.Lys280del")) causesNoChange bp(GO:"cell death")
pmid:25374103 p(HBP:"4R tau", var("p.Lys280del")) negativeCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 p(HBP:"4R tau", var("p.Lys280del")) negativeCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:29191965 p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) increases path(MESH:Paralysis)
pmid:29191965 p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases act(a(MESH:Neurons))
pmid:29191965 p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) negativeCorrelation bp(GO:"cell aging")
pmid:29191965 p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(MESH:Longevity)
pmid:29191965 p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(GO:"anterograde axonal transport of mitochondrion")
pmid:29191965 bp(GO:"cell aging") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr"))
pmid:29191965 complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases act(a(GO:"synaptic vesicle"))
pmid:29191965 complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases bp(MESH:"Synaptic Transmission")
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:CHRNA7)) decreases bp(GO:locomotion)
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:BAIAP3)) decreases bp(GO:locomotion)
pmid:29191965 p(HGNC:BAIAP3) regulates bp(GO:"retrograde trans-synaptic signaling")
pmid:29191965 a(GO:"cell body") association p(HGNC:MAPT)
pmid:29191965 p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:29191965 p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:29191965 composite(p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")), p(HGNC:CDK5)) decreases a(MESH:Neurons)
pmid:29191965 a(PUBCHEM:6475963) decreases a(HBP:"Tau aggregates")
pmid:29191965 a(PUBCHEM:6475963) positiveCorrelation bp(GO:locomotion)
pmid:29191965 a(PUBCHEM:66766582) decreases path(HBP:Neurodegeneration)
pmid:29191965 a(CHEBI:azaperone) increases bp(GO:locomotion)
pmid:29191965 a(CHEBI:azaperone) decreases p(HGNC:MAPT)
pmid:29191965 a(CHEBI:azaperone) decreases path(HBP:Neurodegeneration)
pmid:29191965 composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases bp(MESH:Longevity)
pmid:29191965 composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases bp(GO:locomotion)
pmid:29191965 composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) positiveCorrelation bp(GO:"insulin receptor signaling pathway")
pmid:29191965 p(HGNC:WNT2) association path(MESH:Tauopathies)
pmid:29191965 p(HGNC:TTBK2) association path(MESH:Tauopathies)
pmid:17620722 p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 208))
pmid:17620722 p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 210))
pmid:25673844 p(HGNC:TTBK2) isA p(HBP:"CK1 superfamily")
pmid:25673844 p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 42))
pmid:25673844 p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 45))
pmid:25673844 p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 47))
pmid:25673844 p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 80))
pmid:25673844 p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 81))
pmid:25673844 p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Thr, 84))
pmid:25473830 p(HGNC:TTBK2) directlyIncreases p(HGNC:TARDBP, pmod(Ph))
pmid:25473830 p(HGNC:TTBK2) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm))
pmid:27607061 p(HGNC:TTBK2) decreases surf(p(HGNC:GRIK2))
pmid:26323690 p(HGNC:TTBK2) increases p(HGNC:KIF2A, pmod(Ph))
pmid:26323690 p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12))
pmid:26323690 p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1))
pmid:26323690 p(HGNC:TTBK2) association p(HGNC:CEP164)
pmid:26323690 act(p(HGNC:TTBK2)) positiveCorrelation p(HGNC:CEP164)
pmid:26323690 p(HGNC:TTBK2) association p(HGNC:MAPRE1)
pmid:26323690 act(p(HGNC:TTBK2)) decreases p(HGNC:CCP110)
pmid:26323690 act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(Ph))
pmid:26323690 act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(Ph))
pmid:29191965 p(HGNC:TAOK1) association path(MESH:Tauopathies)
pmid:25974414 act(p(HGNC:TAOK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17))
pmid:29191965 p(HGNC:CTSE) association path(MESH:Tauopathies)
pmid:29191965 p(HGNC:DNMBP) increases complex(p(HGNC:DNMBP), p(HGNC:ENAH))
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DNMBP)) increases path(MESH:Tauopathies)
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) decreases bp(GO:locomotion)
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) increases path(HBP:Neurodegeneration)
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) increases p(HGNC:MAPT)
pmid:29191965 p(HGNC:ZC3H14) increases path(MESH:Tauopathies)
pmid:29191965 p(HGNC:ZC3H14) regulates bp(GO:"aggresome assembly")
pmid:29191965 bp(GO:"aggresome assembly") association path(MESH:"Neurodegenerative Diseases")
pmid:29191965 bp(GO:"aggresome assembly") decreases p(MESH:Proteins, pmod(HBP:misfolding))
pmid:29191965 p(HGNC:DDC) increases a(CHEBI:dopamine)
pmid:29191965 p(HGNC:DDC) increases a(CHEBI:serotonin)
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) decreases bp(GO:locomotion)
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT)
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT, pmod(Ph))
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases path(HBP:Neurodegeneration)
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TH)) causesNoChange path(MESH:Tauopathies)
pmid:29191965 p(HGNC:GCH1) regulates a(CHEBI:dopamine)
pmid:29191965 p(HGNC:GCH1) regulates a(CHEBI:serotonin)
pmid:29191965 p(HGNC:GCH1) regulates act(p(HGNC:DDC))
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:GCH1)) causesNoChange path(MESH:Tauopathies)
pmid:29191965 p(HGNC:TPH1) regulates a(CHEBI:dopamine)
pmid:29191965 p(HGNC:TPH1) regulates a(CHEBI:serotonin)
pmid:29191965 p(HGNC:TPH1) regulates act(p(HGNC:DDC))
pmid:29191965 composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TPH1)) causesNoChange path(MESH:Tauopathies)
pmid:29686391 a(HBP:"sonicated tau fibrils") positiveCorrelation tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"sonicated tau fibrils")
pmid:29686391 g(HGNC:TP53) increases bp(GO:"mitotic G1 phase")
pmid:29686391 g(HGNC:TP53) decreases bp(GO:"cell proliferation")
pmid:29686391 bp(GO:"mitotic G1 phase") positiveCorrelation bp(GO:endocytosis)
pmid:29686391 bp(GO:"mitotic G1 phase") regulates tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:CDK6) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(CHEBI:palbociclib) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4))
pmid:29686391 a(CHEBI:palbociclib) decreases act(p(HGNC:CDK6))
pmid:29686391 p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process")
pmid:29686391 p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:EXT2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2)
pmid:29686391 bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1)
pmid:29686391 p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process")
pmid:29686391 p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:HS6ST1) increases a(HBP:"6-O-sulfated heparin")
pmid:29686391 p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:DNM2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(HBP:"6-O-sulfated heparin") positiveCorrelation complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)"))
pmid:29686391 a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(HBP:"6-O-sulfated heparin") association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(MESH:"Heparitin Sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) positiveCorrelation a(HBP:"6-O-sulfated heparin")
pmid:29686391 a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(CHEBI:"chondroitin sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 a(CHEBI:"chondroitin sulfate") causesNoChange tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:SULF1) decreases a(HBP:"6-O-sulfated heparin")
pmid:29686391 p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
pmid:29686391 p(HGNC:SULF2) decreases a(HBP:"6-O-sulfated heparin")
pmid:28877763 p(HGNC:MAPT, pmod(HBP:misfolded)) positiveCorrelation act(p(HGNC:SYK))
pmid:25374103 composite(p(HGNC:MAPT), p(HGNC:MARK2)) positiveCorrelation bp(GO:"anterograde axonal transport")
pmid:25374103 p(MGI:Stub1) decreases act(p(MGI:Casp3))
pmid:25374103 p(MGI:Stub1) decreases p(HBP:"Tau C3")
pmid:25374103 composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau isoform F (441 aa)")
pmid:25374103 composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases a(MESH:"HSP70 Heat-Shock Proteins")
pmid:25374103 composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?"))
pmid:25374103 composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3")
pmid:25374103 composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3")
pmid:25374103 composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins")
pmid:25374103 composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?"))
pmid:25374103 composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del"))
pmid:25374103 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del"))
pmid:25374103 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:25374103 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins")
pmid:25374103 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule")
pmid:25374103 a(MESH:"HSP70 Heat-Shock Proteins") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded)))
pmid:25374103 complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded)))
pmid:25374103 p(PFAM:"CHIP_TPR_N") increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(FPLX:HSP90), p(HGNC:STUB1))
pmid:25374103 complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"Tau isoform F (441 aa)")
pmid:25374103 complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"4R tau", var("p.Lys280del"))
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau isoform F (441 aa)")
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau isoform F (441 aa)")
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau C3")
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau C3")
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"4R tau", var("p.Lys280del"))
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"4R tau", var("p.Lys280del"))
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1))
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1))
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau C3"), p(HGNC:STUB1))
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau C3"), p(HGNC:STUB1))
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1))
pmid:25374103 bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1))
pmid:28420982 a(HBP:"granular tau oligomers") increases a(HBP:"Tau fibrils")
pmid:28420982 bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration)
pmid:28420982 a(MESH:Exosomes) association sec(p(HGNC:MAPT))
pmid:29238289 act(a(MESH:Exosomes)) association p(HGNC:MAPT)
pmid:28420982 a(MESH:Exosomes) association path(MESH:"Plaque, Amyloid")
pmid:28420982 a(MESH:Exosomes) association p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:28420982 a(GO:microvesicle) association sec(p(HGNC:MAPT))
pmid:28420982 a(GO:microvesicle) regulates sec(p(HGNC:MAPT))
pmid:28420982 complex(a(GO:vesicle), a(MESH:"Cell Membrane")) increases sec(p(HGNC:MAPT))
pmid:28420982 complex(p(HGNC:CHRM1), p(HGNC:MAPT)) increases path(MESH:Tauopathies)
pmid:28420982 complex(p(HGNC:CHRM3), p(HGNC:MAPT)) increases path(MESH:Tauopathies)
pmid:28420982 complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part"))
pmid:28420982 complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases a(HBP:"Tau aggregates")
pmid:28420982 complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates"))
pmid:28420982 complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases bp(GO:macropinocytosis)
pmid:28420982 a(MESH:"Heparan Sulfate Proteoglycans") association bp(GO:"neurofibrillary tangle assembly")
pmid:28420982 a(MESH:"Heparan Sulfate Proteoglycans") association a(HBP:"dense core plaques")
pmid:28420982 a(MESH:"Heparan Sulfate Proteoglycans") association path(MESH:"Cerebral Amyloid Angiopathy, Familial")
pmid:28420982 a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"Tau fibrils")
pmid:28420982 a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"amyloid-beta fibrils")
pmid:28420982 a(MESH:"Heparan Sulfate Proteoglycans") increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates"))
pmid:28420982 a(MESH:"Heparan Sulfate Proteoglycans") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part"))
pmid:28420982 a(HBP:"dense core plaques") association a(MESH:"Heparan Sulfate Proteoglycans")
pmid:28420982 a(HBP:"Tau annular protofibrils") association path(MESH:Tauopathies)
pmid:28420982 complex(p(HGNC:DNM1L), p(HGNC:MAPT)) increases bp(HP:Neurodegeneration)
pmid:28420982 p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization")
pmid:26631930 p(HGNC:MAPT, frag("1_421")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, frag("1_421")) increases a(GO:"neurofibrillary tangle")
pmid:28420982 p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization")
pmid:28420982 complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9))
pmid:23702978 complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly")
pmid:29311797 path(MESH:"Chronic Traumatic Encephalopathy") isA path(MESH:Tauopathies)
pmid:29276758 path(MESH:"Chronic Traumatic Encephalopathy") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:29311797 p(HGNC:HSP90AA1) association bp(GO:growth)
pmid:29311797 p(HGNC:HSP90AA1) association bp(GO:"regulation of cell cycle")
pmid:29311797 p(HGNC:HSP90AA1) association bp(MESH:Cytoprotection)
pmid:29311797 p(HGNC:HSP90AA1) association path(MESH:"Neoplasm Metastasis")
pmid:29311797 bp(GO:growth) association p(HGNC:HSP90AA1)
pmid:29311797 bp(GO:"regulation of cell cycle") association p(HGNC:HSP90AA1)
pmid:29311797 bp(MESH:Cytoprotection) association p(HGNC:HSP90AA1)
pmid:29311797 path(MESH:"Neoplasm Metastasis") association p(HGNC:HSP90AA1)
pmid:29311797 bp(GO:"embryo development") association p(HGNC:HSP90AB1)
pmid:29311797 bp(GO:"cell maturation") association p(HGNC:HSP90AB1)
pmid:29311797 bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1)
pmid:29311797 p(HGNC:PPID) isA a(MESH:Immunophilins)
pmid:29311797 p(HGNC:PPID) decreases a(HBP:"Tau fibrils")
pmid:29311797 p(HGNC:PPID) decreases a(HBP:"Tau aggregates")
pmid:29311797 p(HGNC:PPID) increases bp(GO:memory)
pmid:29311797 p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process")
pmid:29311797 p(HGNC:FKBPL) isA a(MESH:Immunophilins)
pmid:29311797 complex(p(FPLX:HSP90), p(HGNC:AIP)) regulates bp(GO:"glucocorticoid receptor signaling pathway")
pmid:29311797 bp(GO:"glucocorticoid receptor signaling pathway") association a(HBP:"Tau aggregates")
pmid:29311797 p(HGNC:TOMM34) decreases path(MESH:Tauopathies)
pmid:29311797 complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B)
pmid:29311797 complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13)
pmid:21367866 complex(p(FPLX:HSP90), p(HGNC:CDC37)) positiveCorrelation act(p(HGNC:AKT1), ma(kin))
pmid:29311797 act(p(HGNC:MAPK13), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))
pmid:11943212 p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:11943212 p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 396))
pmid:11943212 p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:11943212 p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:29311797 p(HGNC:S100A1) increases p(HGNC:MAPT)
pmid:29311797 p(HGNC:S100A1) increases p(HGNC:MAPT, pmod(Ph))
pmid:29311797 complex(p(FPLX:HSP90), p(HGNC:FNIP1)) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity"))
pmid:29311797 complex(p(FPLX:HSP90), p(HGNC:FNIP1), p(HGNC:FNIP2)) increases p(HGNC:FLCN)
pmid:29311797 p(FPLX:HSP90, pmod(Ph)) decreases act(p(FPLX:HSP90))
pmid:29311797 p(FPLX:HSP90, pmod(Ac)) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90))
pmid:29311797 p(FPLX:HSP90, pmod(NO)) decreases act(p(FPLX:HSP90))
pmid:29311797 p(FPLX:HSP90, pmod(Ub)) decreases act(p(FPLX:HSP90))
pmid:29311797 a(HBP:EC102) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)))
pmid:29311797 a(PUBCHEM:14719853) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity"))
pmid:29311797 a(PUBCHEM:14719853) decreases p(HGNC:MAPT)
pmid:29311797 a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90))
pmid:29311797 a(CHEBI:"withaferin A") decreases p(HGNC:MAPT)
pmid:29311797 a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37))
pmid:29311797 a(PUBCHEM:4456430) decreases path(MESH:"Alzheimer Disease")
pmid:29311797 a(HBP:"KU-177") decreases p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:26751493 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:26631930 p(HGNC:MAPT, var("p.Pro301Leu")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, var("p.Pro301Leu")) increases bp(GO:memory)
pmid:29121589 p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Astrogliosis)
pmid:29121589 p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Microgliosis)
pmid:29121589 p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Il1b)
pmid:29121589 p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Nos2)
pmid:23294633 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 279))
pmid:23294633 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 216))
pmid:23294633 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:23294633 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:23294633 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:"Tau epitope, AT100")
pmid:23294633 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:11606569 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIINK motif")
pmid:11606569 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIVYK motif")
pmid:27716675 p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:neuroinflammation)
pmid:26751493 r(MGI:Mapt) partOf a(CL:0000127)
pmid:26751493 r(MGI:Mapt) partOf a(CL:0000128)
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:28176663 p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose")
pmid:8226987 p(HGNC:MAPT, pmod(Ph, Ser, 214)) decreases act(p(HGNC:MAPT))
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Tyr, 394)) association a(HBP:"paired helical filaments")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HGNC:MAPT, pmod(Ph, Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26751493 p(HBP:"microtubule-binding region") association p(HGNC:HDAC6)
pmid:26751493 p(HBP:"microtubule-binding region") partOf p(HGNC:MAPT)
pmid:10464280 p(HBP:"microtubule-binding region") isA p(HGNC:MAPT)
pmid:10464280 p(HBP:"microtubule-binding region") association act(complex(GO:"protein phosphatase type 2A complex"))
pmid:10464280 p(HBP:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule))
pmid:18500754 p(HBP:"microtubule-binding region") association p(HGNC:HSPA8)
pmid:18500754 p(HBP:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily")
pmid:8391280 p(HBP:"microtubule-binding region") association p(FPLX:Ubiquitin)
pmid:26751493 p(HBP:"tubulin-binding repeat 1") association g(HBP:"APOE e3")
pmid:26751493 p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"microtubule-binding region")
pmid:17493042 p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region")
pmid:26751493 p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region")
pmid:17493042 p(HBP:"tubulin-binding repeat 1") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("244_274"))
pmid:23407988 p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"4R tau")
pmid:23407988 p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"3R tau")
pmid:26751493 p(HBP:"tubulin-binding repeat 1") association p(HBP:"APOE e3")
pmid:26751493 g(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1")
pmid:26751493 p(HBP:"projection domain") association p(HGNC:LCK)
pmid:26751493 p(HBP:"projection domain") association p(HGNC:FGR)
pmid:26751493 p(HBP:"projection domain") association p(HGNC:SRC)
pmid:26751493 p(HBP:"projection domain") association p(HGNC:GRB2)
pmid:26751493 p(HBP:"projection domain") association p(FPLX:PLC)
pmid:26751493 p(HBP:"projection domain") association a(CHEBI:phosphatidylinositol)
pmid:26751493 p(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate")
pmid:26751493 p(HBP:"projection domain") association p(HGNC:PIN1)
pmid:26751493 p(HBP:"projection domain") partOf p(HGNC:MAPT)
pmid:26751493 p(HBP:"projection domain") association p(HGNC:FYN)
pmid:26751493 p(HBP:"projection domain") association p(HGNC:DLG4)
pmid:26751493 p(HBP:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate")
pmid:26751493 p(HGNC:FGR) association p(HBP:"projection domain")
pmid:26751493 p(HGNC:FGR) association a(HBP:"projection domain")
pmid:26751493 p(HGNC:GRB2) association p(HBP:"projection domain")
pmid:26751493 p(HGNC:GRB2) association a(HBP:"projection domain")
pmid:26751493 a(CHEBI:"phosphatidylinositol bisphosphate") association p(HBP:"projection domain")
pmid:26751493 a(CHEBI:"phosphatidylinositol bisphosphate") association a(HBP:"projection domain")
pmid:26751493 path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau")
pmid:26631930 path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau")
pmid:22057784 path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197))
pmid:17050703 path(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
pmid:21427723 path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:21427723 path(HBP:"Corticobasal Degeneration") isA path(HBP:"4R tauopathy")
pmid:26751493 path(HBP:"Argyrophilic Grain Disease") positiveCorrelation p(HBP:"4R tau")
pmid:26751493 p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:26631930 p(HGNC:MAPT, var("p.Val337Met")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Val337Met")) increases a(HBP:"Tau aggregates")
pmid:26751493 p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:26631930 p(HGNC:MAPT, var("p.Gly272Val")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Gly272Val")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, var("p.Gly272Val")) decreases p(HBP:"4R tau")
pmid:26631930 p(HGNC:MAPT, var("p.Gly272Val")) increases p(HBP:"3R tau")
pmid:26751493 p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:26631930 p(HGNC:MAPT, var("p.Arg406Trp")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Arg406Trp")) increases a(HBP:"Tau aggregates")
pmid:26751493 p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:26751493 p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases")
pmid:26751493 p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:"amyloid-beta")
pmid:26751493 g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease")
pmid:26751493 g(DBSNP:rs242557) association path(MESH:"Parkinson Disease")
pmid:26751493 p(HGNC:MAPT, var("p.Glu391*")) association p(HBP:"paired helical filaments")
pmid:25974414 p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle")
pmid:22002427 p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle")
pmid:25974414 p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25974414 p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT)
pmid:22002427 p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:22002427 p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205))
pmid:26751493 p(HBP:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*"))
pmid:26751493 p(HBP:"paired helical filaments") partOf a(GO:"neurofibrillary tangle")
pmid:26751493 p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle")
pmid:26751493 p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle")
pmid:26751493 complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis)
pmid:26751493 bp(GO:"cell-cell signaling via exosome") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons))
pmid:26751493 a(CL:0000129) increases tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons))
pmid:26751493 a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(ECCODE:"3.1.1.89"))
pmid:26751493 a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") positiveCorrelation act(complex(GO:"respiratory chain complex I"))
pmid:29281045 p(ECCODE:"3.1.1.89") decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
pmid:26751493 act(complex(GO:"respiratory chain complex I")) positiveCorrelation a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid")
pmid:26751493 p(HBP:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:28019679 p(HGNC:CASP1) increases act(p(HGNC:IL18))
pmid:23702978 act(p(HGNC:CASP1)) increases act(p(HGNC:IL18))
pmid:23702978 act(p(HGNC:CASP1)) increases act(p(HGNC:IL18))
pmid:23702978 act(p(HGNC:CASP1)) increases sec(p(HGNC:IL18))
pmid:24561250 p(HGNC:CASP1) increases p(HGNC:IL18)
pmid:24561250 p(HGNC:CASP1) increases p(HGNC:IL18)
pmid:27314526 act(p(HGNC:CASP1)) increases act(p(HGNC:IL18))
pmid:27314526 sec(p(HGNC:CASP1)) increases act(p(HGNC:IL18))
pmid:27314526 act(p(HGNC:CASP1)) increases act(p(HGNC:IL18))
pmid:27314526 act(p(HGNC:CASP1)) increases act(p(HGNC:IL18))
pmid:28019679 p(HGNC:CASP1) increases act(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:CASP1)) increases sec(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B))
pmid:24561250 p(HGNC:CASP1) increases p(HGNC:IL1B)
pmid:27314526 act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B))
pmid:27314526 sec(p(HGNC:CASP1)) increases act(p(HGNC:IL1B))
pmid:27314526 act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B))
pmid:27314526 act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B))
pmid:28019679 act(p(HGNC:CASP1)) increases a(CHEBI:"nitric oxide")
pmid:28019679 act(p(HGNC:CASP1)) increases sec(p(HGNC:TNF))
pmid:28019679 act(p(HGNC:CASP1)) increases bp(GO:pyroptosis)
pmid:23702978 act(p(HGNC:CASP1)) increases bp(GO:pyroptosis)
pmid:24561250 p(HGNC:CASP1) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:27314526 act(p(HGNC:CASP1)) increases act(p(HGNC:IL33))
pmid:27314526 act(p(HGNC:CASP1)) increases act(p(HGNC:IL33))
pmid:26751493 p(HGNC:MAPT, pmod(Ac, Lys, 274)) positiveCorrelation p(HBP:"Tau aggregates")
pmid:27041503 p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases p(HGNC:WWC1)
pmid:27041503 p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases bp(GO:"actin filament polymerization")
pmid:26751493 a(HBP:thiohydantoin) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(HBP:oxazolidinedione) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(HBP:thioxooxazolidine) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:thiostrepton) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(HBP:sudoxicam) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:isoniazide) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:Iproniazid) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:iproclozide) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(HBP:isocarboxazide) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:myricetin) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:emodin) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:daunorubicin) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:doxorubicin) decreases p(HBP:"Tau aggregates")
pmid:26751493 a(CHEBI:quinalizarin) decreases p(HBP:"Tau aggregates")
pmid:26458742 p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Thr, 205))
pmid:26458742 p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 262))
pmid:26458742 p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 400))
pmid:26458742 p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 404))
pmid:26458742 p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 409))
pmid:26458742 p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 422))
pmid:26458742 p(HBP:HBP00056, var("p.Pro301Leu")) increases a(HBP:HBP00006)
pmid:26195256 bp(GO:"import into cell") decreases a(HBP:"amyloid-beta derived diffusible ligands")
pmid:26195256 a(MESH:"Extracellular Fluid") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))
pmid:26195256 p(HGNC:CLU) association path(MESH:"Alzheimer Disease")
pmid:26195256 path(MESH:"Craniocerebral Trauma") association path(MESH:"Alzheimer Disease")
pmid:26195256 path(MESH:"Sleep Initiation and Maintenance Disorders") association path(MESH:"Alzheimer Disease")
pmid:26195256 path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease")
pmid:26195256 a(MESH:"Cerebral Ventricles") association path(MESH:"Alzheimer Disease")
pmid:26195256 p(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) negativeCorrelation p(HGNC:APP, loc(GO:"extracellular region"))
pmid:26195256 act(p(MESH:Ubiquitin)) decreases p(HGNC:APP)
pmid:26195256 act(p(MESH:Ubiquitin)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:Ubiquitin) decreases p(HGNC:MAPT)
pmid:26195256 act(complex(a(MESH:Endosomes), a(MESH:Lysosomes))) decreases p(HGNC:APP)
pmid:26195256 act(p(MESH:"Amyloid Precursor Protein Secretases")) increases a(CHEBI:"amyloid-beta")
pmid:26195256 a(HBP:"amyloid-beta polypeptide 38") isA a(CHEBI:"amyloid-beta")
pmid:26195256 act(p(MESH:Cathepsins)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:Neprilysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:"Matrix Metalloproteinase 9") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:"Matrix Metalloproteinase 2") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:"Matrix Metalloproteinase 3") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:"Glutamate Carboxypeptidase II") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:"Endothelin-Converting Enzymes") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:"Tissue Plasminogen Activator") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(MESH:Fibrinolysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:26195256 p(HGNC:ACE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular))
pmid:29626319 p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II")))
pmid:29626319 p(HGNC:ACE) regulates a(MESH:"Body Fluids")
pmid:29626319 p(HGNC:ACE) regulates bp(MESH:"Blood Pressure")
pmid:29626319 p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport")
pmid:29626319 act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26195256 a(MESH:"Muscle, Smooth, Vascular") decreases a(CHEBI:"amyloid-beta")
pmid:26195256 a(MESH:Insulin) increases a(CHEBI:"amyloid-beta")
pmid:26195256 a(MESH:Insulin) association a(CHEBI:"amyloid-beta")
pmid:26195256 p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta"))
pmid:26195256 p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(GO:"extracellular region"))
pmid:29626319 p(HGNC:ABCB1) decreases a(CHEBI:"amyloid-beta")
pmid:26195256 p(HGNC:A2M) regulates a(CHEBI:"amyloid-beta")
pmid:26195256 p(HGNC:LRP2) regulates a(CHEBI:"amyloid-beta")
pmid:26195256 p(HGNC:PPIA) association act(a(MESH:"Blood-Brain Barrier"))
pmid:26195256 bp(HBP:"perivascular drainage pathways") association a(CHEBI:"amyloid-beta")
pmid:26195256 path(HBP:"high-fat prenatal maternal diet") increases a(CHEBI:"amyloid-beta")
pmid:26195256 path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier"))
pmid:26195256 path(MESH:Sleep) increases bp(HBP:"glymphatic bulk flow")
pmid:29626319 path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta")
pmid:26195256 act(p(MESH:Lysosomes)) decreases p(HGNC:MAPT)
pmid:26195256 p(MESH:"Cyclic AMP-Dependent Protein Kinases") increases p(HGNC:MAPT, pmod(Ph))
pmid:26195256 act(p(MESH:Calpain)) decreases p(HGNC:MAPT)
pmid:26195256 p(HBP:"tau aggregates") association path(MESH:"Brain Injuries, Traumatic")
pmid:27373205 p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau aggregates")
pmid:27373205 p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau oligomers")
pmid:27373205 p(HGNC:MAPT, var("p.S422E")) decreases bp(GO:"anterograde axonal protein transport")
pmid:27373205 p(HGNC:MAPT, var("p.S422E")) causesNoChange bp(GO:"retrograde axonal protein transport")
pmid:27373205 composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau oligomers")
pmid:27373205 composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau dimers")
pmid:27373205 composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"anterograde axonal protein transport")
pmid:27373205 composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"retrograde axonal protein transport")
pmid:27373205 composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers")
pmid:27373205 composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau dimers")
pmid:27373205 composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) decreases bp(GO:"anterograde axonal protein transport")
pmid:27373205 composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) causesNoChange bp(GO:"retrograde axonal protein transport")
pmid:26631930 g(HGNC:MIR132) negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:26631930 g(HGNC:MIR132) decreases p(HBP:"4R tau")
pmid:26631930 g(HGNC:MIR219A1) increases complex(g(HGNC:MIR219A1), p(HGNC:MAPT))
pmid:26631930 complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) decreases p(HGNC:MAPT)
pmid:26631930 p(HGNC:G3BP1) increases complex(GO:"ribonucleoprotein granule")
pmid:26631930 complex(GO:"ribonucleoprotein granule") increases p(HGNC:MAPT)
pmid:26631930 p(HGNC:HM13) increases complex(GO:"ribonucleoprotein granule")
pmid:26631930 a(PUBCHEM:354398) decreases act(complex(GO:"mitochondrial respiratory chain complex I"))
pmid:26631930 complex(GO:"mitochondrial respiratory chain complex I") decreases p(HGNC:SRSF2)
pmid:26631930 p(HGNC:SRSF2) increases p(HBP:"4R tau")
pmid:29226865 act(p(HGNC:SRSF2)) increases p(HBP:"4R tau")
pmid:26631930 p(HGNC:SRSF2) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:29226865 act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(Ac, Lys, 52))
pmid:26631930 complex(a(MESH:RNA), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates")
pmid:26631930 complex(a(MESH:RNA), p(HGNC:MAPT)) increases path(HBP:Neurodegeneration)
pmid:24561250 a(MESH:RNA) increases act(complex(GO:"inflammasome complex"))
pmid:26631930 complex(a(GO:microtubule), p(HBP:"4R tau")) increases bp(GO:"microtubule polymerization")
pmid:26631930 complex(a(GO:microtubule), p(HBP:"3R tau")) increases bp(GO:"microtubule polymerization")
pmid:26631930 p(HGNC:PPM1A) directlyDecreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Ser, 214), pmod(Ph, Thr, 231)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1))
pmid:26631930 p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)))
pmid:26631930 complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex")
pmid:26631930 complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex")
pmid:26631930 complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases bp(GO:"axonal transport")
pmid:26631930 complex(GO:"kinesin complex") regulates bp(GO:"axonal transport")
pmid:19491104 act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:MAPK8IP1))
pmid:19491104 act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1))
pmid:19491104 act(complex(GO:"kinesin complex")) positiveCorrelation bp(GO:"vesicle-mediated transport")
pmid:26631930 p(HGNC:EP300) increases p(HGNC:MAPT, pmod(Ac, Lys))
pmid:11691934 p(HGNC:EP300) increases p(FPLX:"Histone_H4", pmod(Ac))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 163))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 174))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 180))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 254))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 274))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 281))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 290))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 298))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 317))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 321))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 331))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 352))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 369))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 370))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 383))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 385))
pmid:20869593 act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 395))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 280)))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:29276758 p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:21427723 p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Niemann-Pick Diseases")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:29276758 p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases a(MESH:Neurons)
pmid:29276758 p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Chronic Traumatic Encephalopathy")
pmid:28855586 p(HGNC:MAPT, pmod(Ac, Lys, 280)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369)))
pmid:28287136 p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:28287136 p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:"Tau aggregates")
pmid:28287136 p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf p(HBP:"VQIINK motif")
pmid:26940749 p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:26940749 p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:Neurodegeneration)
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 280)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf a(HBP:"microtubule-binding region")
pmid:21427723 p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(HBP:"Corticobasal Degeneration")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 163)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 163)))
pmid:28855586 p(HGNC:MAPT, pmod(Ac, Lys, 163)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369)))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 163)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 281)))
pmid:28855586 p(HGNC:MAPT, pmod(Ac, Lys, 281)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369)))
pmid:28287136 p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:28287136 p(HGNC:MAPT, pmod(Ac, Lys, 281)) increases a(HBP:"Tau aggregates")
pmid:28287136 p(HGNC:MAPT, pmod(Ac, Lys, 281)) partOf p(HBP:"VQIINK motif")
pmid:27041503 p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:WWC1)
pmid:27041503 p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases bp(GO:"actin filament polymerization")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 369)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 369)))
pmid:28855586 p(HGNC:MAPT, pmod(Ac, Lys, 369)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369)))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 369)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 369)) partOf a(HBP:"microtubule-binding region")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 259)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 259)))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases a(HBP:"Tau aggregates")
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 259)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 259)) partOf a(HBP:"microtubule-binding region")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 290)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 290)))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 321)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 321)))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases a(HBP:"Tau aggregates")
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 321)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 321)) partOf a(HBP:"microtubule-binding region")
pmid:28760828 p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HBP:"Tau aggregates")
pmid:28760828 p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 324))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 353)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 353)))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(Ac, Lys, 174)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26390242 p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases deg(p(HGNC:MAPT))
pmid:26390242 p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:26390242 p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:26390242 p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases a(HBP:Neurodegeneration)
pmid:29540553 p(HGNC:MAPT, pmod(Ac, Lys, 174)) negativeCorrelation act(p(HGNC:SIRT1))
pmid:26631930 p(HGNC:MAPT, pmod(NGlyco)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(NGlyco)) regulates a(HBP:"paired helical filaments")
pmid:26631930 p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:26631930 p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(Ph))
pmid:26631930 p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:glycation)) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:glycation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:19517062 p(HGNC:MAPT, pmod(HBP:glycation)) increases a(CHEBI:"advanced glycation end-product")
pmid:19517062 p(HGNC:MAPT, pmod(HBP:glycation)) partOf p(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:deamidation)) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:Tauopathies)
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases bp(GO:"tubulin complex assembly")
pmid:22057784 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:18562203 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) association act(a(MESH:Astrocytes))
pmid:18562203 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) isA p(HGNC:MAPT, pmod(HBP:nitration))
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation a(HBP:"paired helical filaments")
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:Tauopathies)
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases bp(GO:"tubulin complex assembly")
pmid:22057784 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf a(GO:"neurofibrillary tangle")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf path(MESH:"Plaque, Amyloid")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(HBP:"Corticobasal Degeneration")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) isA p(HGNC:MAPT, pmod(HBP:nitration))
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation a(HBP:"paired helical filaments")
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:Tauopathies)
pmid:26631930 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases bp(GO:"tubulin complex assembly")
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation a(HBP:"paired helical filaments")
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates")
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, frag("26_230")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26631930 p(HGNC:MAPT, frag("124_441")) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT, frag("124_441")))
pmid:26631930 complex(p(HGNC:DCTN1), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:DCTN1))
pmid:8391280 complex(p(HGNC:DCTN1), p(HGNC:MAPT)) isA p(INTERPRO:"Dynein associated protein")
pmid:8391280 complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424)
pmid:26631930 complex(a(GO:microtubule), p(HGNC:DCTN1)) increases complex(a(GO:microtubule), a(MESH:Dyneins))
pmid:26631930 complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases sec(a(CHEBI:"iron(0)"))
pmid:26631930 complex(a(MESH:Actins), p(HGNC:MAPT)) increases a(GO:"actin filament bundle")
pmid:26631930 complex(a(MESH:Actins), p(HGNC:MAPT)) regulates a(GO:"actin cytoskeleton")
pmid:26631930 p(HGNC:MAPT, var("p.Asn279Lys")) decreases complex(a(GO:microtubule), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Asn279Lys")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport")
pmid:26631930 p(HGNC:MAPT, var("p.Arg5His")) decreases act(p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Arg5Leu")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT))
pmid:26631930 p(HGNC:MAPT, var("p.Arg5Leu")) decreases bp(GO:"axonal transport")
pmid:26631930 p(HGNC:MAPT, var("p.Leu266Val")) decreases p(HBP:"4R tau")
pmid:26631930 p(HGNC:MAPT, var("p.Leu266Val")) increases p(HBP:"3R tau")
pmid:26631930 p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates")
pmid:26631930 p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates")
pmid:17493042 p(HBP:"VQIINK motif") partOf p(HBP:"tubulin-binding repeat 2")
pmid:17493042 p(HBP:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly")
pmid:28002468 p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("992_999"))
pmid:28002468 p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("1023_1030"))
pmid:11606569 p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del"))
pmid:11606569 p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:11606569 p(HBP:"VQIINK motif") increases p(HBP:"Tau aggregates")
pmid:26631930 p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates")
pmid:26631930 p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates")
pmid:26631930 p(HBP:"VQIVYK motif") increases a(HBP:"Tau fibrils")
pmid:17493042 p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3")
pmid:23531502 p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3")
pmid:17493042 p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly")
pmid:23531502 p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly")
pmid:19363271 p(HBP:"VQIVYK motif") association p(FPLX:HSP90)
pmid:19363271 p(HBP:"VQIVYK motif") isA p(HBP:"tubulin-binding repeat 4")
pmid:19363271 p(HBP:"VQIVYK motif") increases complex(p(FPLX:HSP90), p(HGNC:MAPT))
pmid:23531502 p(HBP:"VQIVYK motif") positiveCorrelation p(HBP:"KXGS motif")
pmid:28002468 p(HBP:"VQIVYK motif") equivalentTo p(HGNC:MAP2, frag("332_339"))
pmid:11606569 p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del"))
pmid:11606569 p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:11606569 p(HBP:"VQIVYK motif") increases p(HBP:"Tau aggregates")
pmid:26903089 p(HBP:"VQIVYK motif") association act(p(HGNC:FKBP4))
pmid:26631930 a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates")
pmid:26631930 a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:YWHAZ) increases a(HBP:"Tau aggregates")
pmid:12551948 p(HGNC:YWHAZ) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ))
pmid:12551948 p(HGNC:YWHAZ) association p(HGNC:MAPT)
pmid:12551948 p(HGNC:YWHAZ) association p(HGNC:GSK3B)
pmid:12551948 p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B))
pmid:26631930 p(HGNC:MAPT, frag("151_391")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, frag("1_368")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:MAPT, frag("1_368")) increases path(HBP:Neurodegeneration)
pmid:26631930 p(HGNC:MAPT, frag("1_368")) decreases bp(GO:"microtubule polymerization")
pmid:26631930 p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360"))
pmid:26631930 p(HGNC:MAPT, frag("258_360")) increases a(HBP:"Tau aggregates")
pmid:26631930 p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360"))
pmid:26631930 tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases act(a(CHEBI:"amyloid-beta"))
pmid:26631930 p(HGNC:SPAST) increases bp(GO:"microtubule severing")
pmid:26631930 complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(GO:"glutamatergic synapse"))
pmid:26631930 complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(CHEBI:"amyloid-beta"))
pmid:26631930 p(HGNC:GRIN2B, pmod(Ph)) increases complex(p(HGNC:DLG4), p(HGNC:FYN))
pmid:21548880 p(HGNC:GRIN2B) negativeCorrelation p(HGNC:TTBK1)
pmid:22817713 complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport")
pmid:22817713 complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport")
pmid:22817713 bp(GO:"regulation of microtubule cytoskeleton organization") association p(HGNC:MAPT)
pmid:22817713 a(CHEBI:"arachidonic acid") increases a(HBP:"Tau oligomers")
pmid:22817713 a(CHEBI:"arachidonic acid") increases a(HBP:"Tau aggregates")
pmid:22817713 p(HGNC:PPP1CA) decreases bp(GO:"anterograde axonal protein transport")
pmid:29334120 p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 397))
pmid:29334120 p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403))
pmid:29334120 p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404))
pmid:29334120 p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409))
pmid:29334120 p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410))
pmid:26142647 act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(Ph))
pmid:21734277 act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:21734277 act(p(HGNC:PPP1CA)) increases act(p(HGNC:GSK3B))
pmid:21734277 act(p(HGNC:PPP1CA)) negativeCorrelation bp(GO:"axonal transport")
pmid:25001178 act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:22817713 p(HGNC:MAPT, frag("2_18")) decreases bp(GO:"anterograde axonal protein transport")
pmid:26671985 p(HGNC:MAPT, frag("2_18")) equivalentTo p(HBP:"phosphatase-activating domain")
pmid:26671985 p(HGNC:MAPT, frag("2_18")) partOf p(HGNC:MAPT, frag("1_151"))
pmid:22817713 composite(p(HGNC:HSPA1A), p(HGNC:MAPT, frag("2_18"))) decreases bp(GO:"anterograde axonal protein transport")
pmid:29626319 p(FPLX:UBE2) increases deg(a(MESH:Proteins))
pmid:29626319 a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins))
pmid:29626319 p(HGNC:PSMD7) increases deg(a(MESH:Proteins))
pmid:29626319 a(HBP:"20 S Proteasome") increases bp(GO:"proteasomal ubiquitin-independent protein catabolic process")
pmid:29626319 a(MESH:"Tight Junctions") decreases tloc(a(MESH:Proteins), fromLoc(MESH:Brain), toLoc(MESH:Blood))
pmid:29626319 a(HP:"glymphatic system") decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(HP:"glymphatic system") decreases p(HGNC:MAPT)
pmid:29626319 p(HGNC:UBB, var("?")) decreases act(p(HGNC:PSMD7))
pmid:29626319 p(HGNC:UBB, var("?")) decreases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(FPLX:MMP) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:ECE1) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29626319 act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29626319 act(p(HGNC:MMP3)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(MESH:"Receptors, Scavenger") increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:CMKLR1) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(FPLX:TLR) increases deg(a(CHEBI:"amyloid-beta"))
pmid:23702978 act(p(FPLX:TLR)) increases p(HGNC:NLRP3)
pmid:23702978 act(p(FPLX:TLR)) increases p(HGNC:IL1B)
pmid:29626319 p(HGNC:FPR2) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:ABCA7) association bp(GO:phagocytosis)
pmid:29626319 p(HGNC:ABCA7) regulates bp(GO:phagocytosis)
pmid:29626319 p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 p(HGNC:ABCA7) decreases p(HGNC:BACE1)
pmid:29626319 p(HGNC:CD33) association bp(GO:phagocytosis)
pmid:29626319 p(HGNC:CD33) decreases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia))
pmid:29626319 p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:"amyloid-beta")
pmid:29626319 p(HGNC:SLC2A1) increases p(HGNC:LRP1)
pmid:29626319 p(HGNC:SLC2A1) regulates deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:SLC2A1) regulates tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood))
pmid:29626319 p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier"))
pmid:29626319 p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier")
pmid:29626319 a(HP:"blood-cerebrospinal fluid barrier") decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(MESH:"Choroid Plexus") increases a(MESH:"Cerebrospinal Fluid")
pmid:29626319 p(HGNC:AQP1) increases act(a(MESH:"Choroid Plexus"))
pmid:29626319 p(HGNC:AQP1) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 complex(a(CHEBI:"amyloid-beta"), p(HGNC:TTR)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(MESH:"Lymph Nodes") decreases a(CHEBI:"amyloid-beta")
pmid:29626319 complex(a(MESH:Erythrocytes), p(HGNC:CR1)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 composite(a(CHEBI:"amyloid-beta"), a(MESH:"Serum Albumin")) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(MESH:Aminopeptidases) increases deg(p(HGNC:MAPT))
pmid:29626319 a(MESH:Thrombin) increases deg(p(HGNC:MAPT))
pmid:29626319 a(MESH:tenuigenin) decreases a(CHEBI:"amyloid-beta polypeptide 40")
pmid:29626319 a(MESH:tenuigenin) increases p(HGNC:PSMD7)
pmid:29626319 bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7)
pmid:29626319 a(CHEBI:wogonin) increases bp(GO:autophagy)
pmid:29626319 a(CHEBI:wogonin) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(CHEBI:wogonin) decreases p(HGNC:MAPT, pmod(Ph))
pmid:29626319 p(HGNC:NPAS4) increases bp(GO:autophagy)
pmid:29626319 p(HGNC:NPAS4) increases deg(p(HGNC:MAPT))
pmid:29626319 p(HGNC:NPAS4) increases deg(p(HGNC:MAPT, pmod(Ph)))
pmid:29626319 a(CHEBI:statin) increases sec(p(HGNC:IDE))
pmid:29626319 a(CHEBI:statin) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(CHEBI:"omega-3 fatty acid") increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(CHEBI:"all-cis-5,8,11,14,17-icosapentaenoic acid") increases act(p(HGNC:IDE))
pmid:29626319 a(CHEBI:"docosahexaenoic acid") increases act(p(HGNC:IDE))
pmid:29626319 a(CHEBI:"docosahexaenoic acid") increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes))
pmid:29626319 a(CHEBI:atorvastatin) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(CHEBI:atorvastatin) increases sec(p(HGNC:MME))
pmid:29626319 a(CHEBI:nobiletin) increases act(p(HGNC:MME))
pmid:29626319 a(CHEBI:nobiletin) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(CHEBI:"ginsenoside Rg1") increases act(p(HGNC:MME))
pmid:29626319 a(CHEBI:"ginsenoside Rg1") decreases path(MESH:Tauopathies)
pmid:29626319 a(MESH:"Granulocyte Colony-Stimulating Factor") increases act(p(HGNC:MME))
pmid:29626319 a(MESH:"Granulocyte Colony-Stimulating Factor") decreases path(MESH:Tauopathies)
pmid:29626319 p(HGNC:ANXA1) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 p(HGNC:ANXA1) increases act(p(HGNC:MME))
pmid:29626319 a(CHEBI:minocycline) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 complex(a(MESH:"Chemokine CX3CL1"), p(HGNC:CX3CR1)) increases deg(a(CHEBI:"amyloid-beta"))
pmid:29626319 a(CHEBI:"disodium cromoglycate") decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(CHEBI:oleocanthal) decreases a(CHEBI:"amyloid-beta")
pmid:29626319 a(CHEBI:oleocanthal) increases p(HGNC:LRP1)
pmid:29626319 a(CHEBI:oleocanthal) increases p(HGNC:ABCB1)
pmid:29238289 complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium)
pmid:29238289 complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) decreases a(MESH:Neurons)
pmid:29238289 complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) decreases p(HGNC:MAPT)
pmid:29238289 p(HGNC:SNAP23) increases p(HGNC:MAPT)
pmid:29238289 p(MESH:"SNARE Proteins") increases p(HGNC:MAPT)
pmid:29238289 p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles"))
pmid:29238289 p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion")
pmid:29238289 a(MESH:"Transport Vesicles") association p(HGNC:MAPT)
pmid:17493042 a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT)
pmid:23531502 a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT)
pmid:10537045 a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT)
pmid:26751493 a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT)
pmid:17493042 a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370"))
pmid:17493042 a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
pmid:21757739 a(HBP:"microtubule-binding region") partOf a(HBP:"assembly domain")
pmid:21757739 a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369"))
pmid:1918161 a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367"))
pmid:10537045 a(HBP:"microtubule-binding region") association act(p(HGNC:TGM2))
pmid:26751493 a(HBP:"microtubule-binding region") association p(HGNC:HDAC6)
pmid:17493042 p(HBP:"tubulin-binding repeat 2") partOf a(HBP:"microtubule-binding region")
pmid:17493042 p(HBP:"tubulin-binding repeat 2") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("275_305"))
pmid:23407988 p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"4R tau")
pmid:23407988 p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"3R tau")
pmid:2123288 p(HBP:"tubulin-binding repeat 2") association p(FPLX:CALM)
pmid:17493042 p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region")
pmid:23531502 p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region")
pmid:17493042 p(HBP:"tubulin-binding repeat 3") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("306_336"))
pmid:23407988 p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"4R tau")
pmid:23407988 p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"3R tau")
pmid:23832849 p(HBP:"tubulin-binding repeat 3") increases a(HBP:"Tau aggregates")
pmid:17493042 p(HBP:"tubulin-binding repeat 4") partOf a(HBP:"microtubule-binding region")
pmid:17493042 p(HBP:"tubulin-binding repeat 4") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("337_367"))
pmid:17493042 p(HBP:"tubulin-binding repeat 4") directlyIncreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
pmid:23407988 p(HBP:"tubulin-binding repeat 4") partOf p(HBP:"4R tau")
pmid:17493042 a(HBP:"projection domain") partOf p(HGNC:MAPT)
pmid:26751493 a(HBP:"projection domain") partOf p(HGNC:MAPT)
pmid:17493042 a(HBP:"projection domain") equivalentTo p(INTERPRO:"MAP2/Tau projection")
pmid:17493042 a(HBP:"projection domain") equivalentTo p(HGNC:MAPT, frag("1_198"))
pmid:26751493 a(HBP:"projection domain") association p(HGNC:LCK)
pmid:26751493 a(HBP:"projection domain") association p(HGNC:FGR)
pmid:26751493 a(HBP:"projection domain") association p(HGNC:SRC)
pmid:26751493 a(HBP:"projection domain") association p(HGNC:GRB2)
pmid:26751493 a(HBP:"projection domain") association p(FPLX:PLC)
pmid:26751493 a(HBP:"projection domain") association a(CHEBI:phosphatidylinositol)
pmid:26751493 a(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate")
pmid:26751493 a(HBP:"projection domain") association p(HGNC:PIN1)
pmid:26751493 a(HBP:"projection domain") association p(HGNC:FYN)
pmid:26751493 a(HBP:"projection domain") association p(HGNC:DLG4)
pmid:26751493 a(HBP:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate")
pmid:17493042 p(INTERPRO:"MAP2/Tau projection") equivalentTo a(HBP:"projection domain")
pmid:8391280 p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1)
pmid:8391280 p(INTERPRO:"MAP2/Tau projection") partOf p(HGNC:MAPT)
pmid:12551948 p(INTERPRO:"MAP2/Tau projection") isA p(HGNC:MAPT)
pmid:12551948 p(INTERPRO:"MAP2/Tau projection") decreases bp(GO:"neuron projection development")
pmid:12551948 p(INTERPRO:"MAP2/Tau projection") negativeCorrelation act(complex(GO:"plasma membrane"))
pmid:17493042 p(HBP:"Tau isoform F (441 aa)", frag("244_274")) equivalentTo p(HBP:"tubulin-binding repeat 1")
pmid:17493042 p(HBP:"Tau isoform F (441 aa)", frag("275_305")) equivalentTo p(HBP:"tubulin-binding repeat 2")
pmid:17493042 p(HBP:"Tau isoform F (441 aa)", frag("306_336")) equivalentTo p(HBP:"tubulin-binding repeat 3")
pmid:17493042 p(HBP:"Tau isoform F (441 aa)", frag("337_367")) equivalentTo p(HBP:"tubulin-binding repeat 4")
pmid:17493042 p(HGNC:MAPT, frag("199_370")) equivalentTo a(HBP:"microtubule-binding region")
pmid:17493042 p(HGNC:MAPT, frag("1_198")) equivalentTo a(HBP:"projection domain")
pmid:17493042 p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(Ph, Ser, 214))
pmid:17493042 bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(Ph, Ser, 214))
pmid:21757739 a(HBP:"assembly domain") equivalentTo p(HGNC:MAPT, frag("199_441"))
pmid:21757739 p(HGNC:MAPT, frag("199_441")) equivalentTo a(HBP:"assembly domain")
pmid:21757739 p(HGNC:MAPT, frag("244_369")) equivalentTo a(HBP:"microtubule-binding region")
pmid:21757739 p(HGNC:MAPT, frag("370_441")) partOf a(HBP:"assembly domain")
pmid:21757739 a(HBP:"proline-rich region 2") equivalentTo p(HGNC:MAPT, frag("199_244"))
pmid:21757739 a(HBP:"proline-rich region 2") partOf a(HBP:"assembly domain")
pmid:21757739 a(HBP:"proline-rich region 2") partOf a(HBP:"proline-rich domain")
pmid:21757739 p(HGNC:MAPT, frag("199_244")) equivalentTo a(HBP:"proline-rich region 2")
pmid:21757739 a(HBP:"proline-rich domain") equivalentTo p(INTERPRO:"PSP, proline-rich")
pmid:22033876 a(HBP:"proline-rich domain") association act(p(FPLX:Actin))
pmid:22033876 a(HBP:"proline-rich domain") association p(INTERPRO:"SH3 domain")
pmid:21757739 p(INTERPRO:"PSP, proline-rich") equivalentTo a(HBP:"proline-rich domain")
pmid:21757739 a(HBP:"proline-rich region 1") equivalentTo p(HGNC:MAPT, frag("151_198"))
pmid:21757739 a(HBP:"proline-rich region 1") partOf a(HBP:"proline-rich domain")
pmid:21757739 a(HBP:"proline-rich region 1") partOf a(HBP:"projection domain")
pmid:21757739 p(HGNC:MAPT, frag("151_198")) equivalentTo a(HBP:"proline-rich region 1")
pmid:21757739 p(HGNC:MAPT, frag("1_151")) partOf a(HBP:"projection domain")
pmid:27260836 complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis")
pmid:27260836 p(HGNC:AP2M1) partOf p(HBP:"AP-2 complex")
pmid:27260836 p(HGNC:AP2B1) partOf p(HBP:"AP-2 complex")
pmid:27260836 p(HGNC:AP2A1) partOf p(HBP:"AP-2 complex")
pmid:27260836 p(HGNC:AP2A2) partOf p(HBP:"AP-2 complex")
pmid:27260836 p(HGNC:AP2S1) partOf p(HBP:"AP-2 complex")
pmid:11943212 a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MARK4, pmod(Ph))
pmid:11943212 a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:27260836 complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:26655600 complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau")
pmid:24368848 p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia")
pmid:23407988 a(HBP:"ghost tangles") decreases complex(GO:"dendritic tree")
pmid:23407988 a(HBP:"Brodmann (1909) area 36") positiveCorrelation p(HBP:"4R tau")
pmid:23407988 a(HBP:"CA1 field of hippocampus") positiveCorrelation p(HBP:"4R tau")
pmid:23407988 a(HBP:"CA2 field of hippocampus") positiveCorrelation p(HBP:"4R tau")
pmid:23407988 a(HBP:"CA3 field of hippocampus") positiveCorrelation p(HBP:"4R tau")
pmid:23407988 a(HBP:"CA4 field of hippocampus") positiveCorrelation p(HBP:"4R tau")
pmid:23407988 act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree")
pmid:22253473 a(MESH:Neuropil) positiveCorrelation p(HBP:"Tau epitope, AT8")
pmid:23407988 complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite))
pmid:22142809 p(HBP:RAC1b) association p(HGNC:NGFR)
pmid:22142809 p(HBP:RAC1b) isA p(HGNC:RAC1)
pmid:22142809 p(HBP:RAC1b) negativeCorrelation p(HGNC:CAV2)
pmid:22142809 p(HBP:RAC1b) negativeCorrelation p(HGNC:GNB4)
pmid:22142809 p(HBP:RAC1b) negativeCorrelation p(HGNC:LIPA)
pmid:22142809 p(HBP:RAC1b) positiveCorrelation a(HBP:"cerebral cortex")
pmid:27087442 act(p(HBP:RAC1b)) negativeCorrelation p(MGI:Cdk5)
pmid:27087442 act(p(HBP:RAC1b)) positiveCorrelation act(a(MESH:Neurons))
pmid:27796283 act(p(HGNC:RAC1)) increases bp(GO:"dendritic spine development")
pmid:22142809 p(HGNC:CAV2) negativeCorrelation p(HBP:RAC1b)
pmid:22142809 p(HGNC:GNB4) negativeCorrelation p(HBP:RAC1b)
pmid:22142809 a(HBP:"cerebral cortex") positiveCorrelation p(HBP:RAC1b)
pmid:6543144 complex(GO:microtubule) association p(HGNC:MAPT)
pmid:10464280 complex(GO:microtubule) association p(HGNC:MAPT)
pmid:19491104 complex(GO:microtubule) association p(HGNC:KIF5B)
pmid:10464280 act(complex(GO:microtubule)) positiveCorrelation p(HBP:"microtubule-binding region")
pmid:10464280 complex(GO:microtubule) association p(HGNC:PPP2CA)
pmid:10464280 act(complex(GO:microtubule)) directlyDecreases act(complex(GO:"protein phosphatase type 2A complex"))
pmid:18500754 act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8))
pmid:18500754 complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family")
pmid:20133804 complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization")
pmid:1918161 p(HGNC:MAPT, frag("237_367")) directlyIncreases complex(GO:microtubule)
pmid:1918161 p(HGNC:MAPT, frag("237_367")) partOf p(HGNC:MAPT)
pmid:1918161 p(HGNC:MAPT, frag("237_367")) equivalentTo a(HBP:"microtubule-binding region")
pmid:1918161 complex(GO:axon) positiveCorrelation p(HGNC:MAPT)
pmid:26671985 act(complex(GO:axon)) negativeCorrelation a(HBP:neurotoxicity)
pmid:1918161 complex(GO:"neuron projection") positiveCorrelation p(HGNC:MAPT)
pmid:17187063 p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) increases a(HBP:Neurodegeneration)
pmid:17187063 a(HBP:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))
pmid:19251756 a(HBP:Neurodegeneration) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase"))
pmid:22952452 a(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:6543144 complex(GO:neurofilament) association p(HGNC:MAPT)
pmid:2446784 complex(GO:"polysomal ribosome") association p(HGNC:MAPT)
pmid:11812770 p(HGNC:MAPT, frag("1_244")) partOf p(HGNC:MAPT)
pmid:11812770 complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B)
pmid:11812770 complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT)
pmid:18680553 p(HGNC:MAPT, frag("223_226")) association p(HGNC:FYN)
pmid:18680553 p(HGNC:MAPT, frag("223_226")) partOf p(HGNC:MAPT)
pmid:18680553 bp(GO:myelination) positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT))
pmid:18680553 bp(GO:myelination) association p(HGNC:MAPT)
pmid:18467332 p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT)
pmid:18467332 p(HGNC:SRC, frag("84_145")) partOf p(HGNC:SRC)
pmid:18467332 p(HGNC:SRC, frag("84_145")) equivalentTo p(INTERPRO:"SH3 domain")
pmid:18467332 p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:SRC, frag("84_145"))
pmid:18467332 p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:PLCG1, frag("790_851"))
pmid:22033876 p(INTERPRO:"SH3 domain") association a(HBP:"proline-rich domain")
pmid:18467332 p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT)
pmid:18467332 p(HGNC:PLCG1, frag("790_851")) partOf p(HGNC:PLCG1)
pmid:18467332 p(HGNC:PLCG1, frag("790_851")) equivalentTo p(INTERPRO:"SH3 domain")
pmid:18467332 p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT)
pmid:18467332 p(HGNC:GRB2, frag("1_57")) isA complex(p(HGNC:GRB2), p(HGNC:MAPT))
pmid:18467332 p(HGNC:GRB2, frag("1_57")) partOf p(HGNC:GRB2)
pmid:18467332 p(HGNC:GRB2, frag("1_57")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain")
pmid:18467332 complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT)
pmid:18467332 p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:GRB2, frag("1_57"))
pmid:18467332 p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:PIK3R1, frag("3_79"))
pmid:18467332 p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT)
pmid:18467332 p(HGNC:PIK3R1, frag("3_79")) partOf p(HGNC:PIK3R1)
pmid:18467332 p(HGNC:PIK3R1, frag("3_79")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain")
pmid:18467332 p(HGNC:PIK3R1) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1))
pmid:19491104 bp(GO:"vesicle-mediated transport") positiveCorrelation act(complex(GO:"kinesin complex"))
pmid:19491104 p(MGI:Mapk8ip1) association p(MGI:Mapt, pmod(Ph))
pmid:19491104 act(p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(Ph))
pmid:19491104 act(p(MGI:Klc1)) negativeCorrelation p(MGI:Mapt, pmod(Ph))
pmid:10464280 rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:18500754 p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(HBP:"microtubule-binding region")
pmid:19363271 a(CHEBI:juglone) increases bp(GO:"neurofibrillary tangle assembly")
pmid:14612456 complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(Ub))
pmid:8391280 p(FPLX:Ubiquitin) association p(HBP:"microtubule-binding region")
pmid:8391280 p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(Ub))
pmid:8391280 act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein"))
pmid:8391280 complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein"))
pmid:8391280 g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia")
pmid:8391280 g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT))
pmid:16176937 p(RGD:Klc1) isA complex(p(RGD:Klc1), p(RGD:Mapt))
pmid:16176937 p(RGD:Klc1) isA p(INTERPRO:"Kinesin motor domain")
pmid:16176937 p(RGD:Klc2) isA complex(p(RGD:Klc2), p(RGD:Mapt))
pmid:16176937 p(RGD:Klc2) isA p(INTERPRO:"Kinesin motor domain")
pmid:16176937 p(INTERPRO:"Kinesin motor domain") association p(RGD:Snca)
pmid:16176937 p(RGD:Snca) isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca))
pmid:16176937 p(RGD:Snca) association p(INTERPRO:"Kinesin motor domain")
pmid:16176937 p(FPLX:"Cytoplasmic_dynein") isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca))
pmid:10391244 p(HGNC:PIN1, frag("5_39")) association p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:10391244 act(p(HGNC:PIN1, frag("5_39"))) positiveCorrelation complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39")))
pmid:10391244 complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) positiveCorrelation act(p(HGNC:PIN1, frag("5_39")))
pmid:10391244 complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle")
pmid:10391244 complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT))
pmid:10391244 p(HGNC:PIN1, var("p.Tyr23Ala")) decreases act(p(HGNC:PIN1, frag("5_39")))
pmid:20133804 p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(Ph))
pmid:20133804 p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(Ph)))
pmid:20133804 p(RGD:Fkbp4) decreases act(p(RGD:Mapt))
pmid:20133804 p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development")
pmid:20133804 p(HGNC:FKBP4, frag("270_386")) association p(FPLX:HSP90)
pmid:20133804 p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4)
pmid:20133804 p(HGNC:FKBP4, frag("270_386")) isA complex(p(FPLX:HSP90), p(HGNC:FKBP4))
pmid:20071522 complex(p(HGNC:AHSA1), p(HGNC:MAPT)) negativeCorrelation p(HGNC:FKBP5)
pmid:2123288 p(FPLX:CALM) association p(HBP:"tubulin-binding repeat 2")
pmid:2123288 act(p(FPLX:CALM)) increases complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM))
pmid:2123288 act(p(FPLX:CALM)) decreases bp(GO:"microtubule polymerization")
pmid:27133022 act(p(FPLX:CALM)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif")
pmid:27133022 act(p(FPLX:CALM)) increases act(p(HGNC:DAPK2))
pmid:2123288 complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT))
pmid:2123288 complex(p(FPLX:CALM), p(HGNC:MAPT)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT))
pmid:2123288 complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) negativeCorrelation act(p(HGNC:MAPT))
pmid:2833519 p(HGNC:S100B) association p(HGNC:MAPT)
pmid:2833519 p(HGNC:S100B) isA complex(p(HGNC:MAPT), p(HGNC:S100B))
pmid:2833519 act(p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family"))
pmid:18494933 p(HGNC:S100B) increases act(p(HGNC:AGER))
pmid:18494933 p(HGNC:S100B) directlyIncreases act(p(HGNC:AGER))
pmid:18494933 p(HGNC:S100B) increases p(FPLX:JNK)
pmid:18494933 p(HGNC:S100B) increases p(FPLX:JNK, pmod(Ph))
pmid:18494933 p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway")
pmid:18494933 p(HGNC:S100B) increases p(HGNC:MAPT, pmod(Ph))
pmid:2833519 complex(p(HGNC:MAPT), p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family"))
pmid:2833519 act(p(FPLX:"CAMK2_family")) increases p(HGNC:MAPT, pmod(Ph))
pmid:12714745 g(DBSNP:rs104893877) positiveCorrelation complex(GO:"neurofibrillary tangle")
pmid:12714745 g(DBSNP:rs104893877) positiveCorrelation complex(GO:"Lewy body")
pmid:12714745 complex(GO:"Lewy body") positiveCorrelation g(DBSNP:rs104893877)
pmid:12714745 composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"neurofibrillary tangle")
pmid:12714745 composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"Lewy body")
pmid:12551948 act(complex(GO:"plasma membrane")) negativeCorrelation p(INTERPRO:"MAP2/Tau projection")
pmid:21339331 p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:21339331 p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 212))
pmid:21339331 p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:21339331 p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:21339331 p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT))
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Thr, 212)) negativeCorrelation p(FPLX:PKA)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212)))
pmid:22072628 p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf p(HBP:"proline-rich region 2", pmod(Ph))
pmid:21339331 p(HGNC:ANXA2) association p(HGNC:MAPT)
pmid:21339331 p(HGNC:ANXA2) association a(MESH:"Cell Membrane")
pmid:21339331 p(HGNC:ANXA2) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT))
pmid:18096814 a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(Palm))
pmid:18096814 a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt)
pmid:18096814 a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn)
pmid:18096814 p(MGI:Fyn, pmod(Palm)) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft"))
pmid:21131359 bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT))
pmid:21131359 bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus))
pmid:21131359 bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT)
pmid:21131359 bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA")
pmid:8226987 bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:19732809 bp(MESH:"Hot Temperature") association a(HBP:"O-GlcNAcylation")
pmid:21131359 a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT)
pmid:21131359 a(CHEBI:"double-stranded DNA") isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT))
pmid:8985176 a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly")
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion))
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion)
pmid:28173111 r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(Ph))
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics")
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn2)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins")
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo2)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43)
pmid:28173111 r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1)
pmid:28173111 r(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1)
pmid:28173111 r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid)
pmid:28173111 r(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam)
pmid:28173111 r(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam)
pmid:28173111 act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 complex(GO:mitochondrion) positiveCorrelation p(MGI:Nrf1)
pmid:28173111 complex(GO:mitochondrion) positiveCorrelation p(MGI:Nfe2l2)
pmid:28173111 complex(GO:mitochondrion) positiveCorrelation p(MGI:Ppargc1a)
pmid:28173111 bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syp)
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Dlg4)
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn1)
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn2)
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins")
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Synpo2)
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Nrgn)
pmid:28173111 act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Gap43)
pmid:28173111 r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 r(MGI:Syp) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 r(MGI:Dlg4) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 r(MGI:Syn1) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(MGI:Syn2) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 r(MGI:Syn2) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(MGI:Synpo2) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 r(MGI:Synpo2) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 r(MGI:Nrgn) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 r(MGI:Gap43) positiveCorrelation act(complex(GO:"neuron to neuron synapse"))
pmid:28173111 r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Fis1) positiveCorrelation bp(GO:"mitochondrial fission")
pmid:28173111 bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Fis1)
pmid:28173111 bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Dnm1l)
pmid:28173111 p(MGI:Dnm1l) positiveCorrelation bp(GO:"mitochondrial fission")
pmid:28173111 r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Ppid) positiveCorrelation complex(GO:"mitochondrial matrix")
pmid:28173111 complex(GO:"mitochondrial matrix") positiveCorrelation p(MGI:Ppid)
pmid:28173111 r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Mfn1) positiveCorrelation bp(GO:"mitochondrial fusion")
pmid:28173111 r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Mfn2) positiveCorrelation bp(GO:"mitochondrial fusion")
pmid:28173111 r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Opa1) positiveCorrelation bp(GO:"mitochondrial fusion")
pmid:28173111 bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn1)
pmid:28173111 bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn2)
pmid:28173111 bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Opa1)
pmid:28173111 r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Nrf1) positiveCorrelation complex(GO:mitochondrion)
pmid:28173111 r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Nfe2l2) positiveCorrelation complex(GO:mitochondrion)
pmid:28173111 r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Ppargc1a) positiveCorrelation complex(GO:mitochondrion)
pmid:25987199 act(p(MGI:Ppargc1a)) positiveCorrelation act(a(GO:mitochondrion))
pmid:28173111 r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l)
pmid:28173111 p(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l)
pmid:25974414 p(HGNC:MAPT, var("p.Asp13*")) partOf a(GO:"neurofibrillary tangle")
pmid:25974414 p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25974414 p(HGNC:MAPT, var("p.Asp13*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Asp25*")) partOf a(GO:"neurofibrillary tangle")
pmid:25974414 p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25974414 p(HGNC:MAPT, var("p.Asp368*")) partOf a(GO:"neurofibrillary tangle")
pmid:25974414 p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:25974414 p(HGNC:MAPT, var("p.Asp421*")) partOf a(GO:"neurofibrillary tangle")
pmid:25974414 p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26671985 p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy")
pmid:26671985 p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation p(HBP:neurotoxicity)
pmid:25974414 p(HGNC:MAPT, var("p.Ala2*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, pmod(HBP:polyamination, Gln, 6)) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Ala103*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(Ac))
pmid:25974414 p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination))
pmid:25974414 p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1))
pmid:25974414 p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2))
pmid:25974414 p(HGNC:MAPT, var("p.Met127*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Pro172*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Lys174*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Lys224*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Ser238*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Lys240*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Lys259*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Gly261*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Val306*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Ile308*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Val309*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Lys311*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Lys331*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Lys395*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Met11*")) isA p(HGNC:MAPT)
pmid:25974414 p(HGNC:MAPT, var("p.Glu12*")) isA p(HGNC:MAPT)
pmid:24844691 p(FPLX:Tubulin, pmod(Ac)) negativeCorrelation act(p(HGNC:HDAC6))
pmid:25974414 act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*"))
pmid:25974414 act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination))
pmid:25974414 act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*"))
pmid:25974414 act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination))
pmid:25974414 p(HGNC:MAPT, pmod(Ph, Thr, 17)) isA p(HGNC:MAPT)
pmid:25974414 act(p(HGNC:TAOK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17))
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) decreases bp(GO:"tubulin complex assembly")
pmid:22057784 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:22057784 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(HBP:"Corticobasal Degeneration")
pmid:22057784 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) partOf a(MESH:"Neuropil Threads")
pmid:17050703 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) isA p(HGNC:MAPT, pmod(HBP:nitration))
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation a(HBP:"paired helical filaments")
pmid:16566606 p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT))
pmid:26671985 a(HBP:neurotoxicity) negativeCorrelation act(complex(GO:axon))
pmid:26671985 p(HBP:"phosphatase-activating domain") positiveCorrelation act(a(HBP:"Tau oligomers"))
pmid:26671985 p(HBP:"phosphatase-activating domain") equivalentTo p(HGNC:MAPT, frag("2_18"))
pmid:26671985 p(HBP:"phosphatase-activating domain") decreases act(complex(GO:axon))
pmid:26671985 p(HBP:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy")
pmid:26671985 p(HBP:"phosphatase-activating domain") decreases bp(GO:"axonal transport")
pmid:27260838 p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT1")
pmid:27260838 p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT2")
pmid:27260838 p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:pretangles)
pmid:27574109 p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"4R tau")
pmid:27373205 p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:21734277 p(HBP:"phosphatase-activating domain") directlyIncreases act(p(HGNC:PPP1CA))
pmid:26671985 p(HBP:neurotoxicity) positiveCorrelation p(HGNC:MAPT, var("p.Asp421*"))
pmid:24869773 p(HGNC:MAPT, pmod(Me2, Lys, 311)) association p(HGNC:MAPT)
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 259)) association p(HGNC:MAPT)
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 259)) isA p(HGNC:MAPT, pmod(Me, Lys))
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT)
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT)
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 290)) isA p(HGNC:MAPT, pmod(Me, Lys))
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 290)) partOf p(HBP:"tubulin-binding repeat 2")
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 353)) association p(HGNC:MAPT)
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 353)) isA p(HGNC:MAPT, pmod(Me, Lys))
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 24)) association p(HGNC:MAPT)
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 24)) isA p(HGNC:MAPT, pmod(Me, Lys))
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 44)) association p(HGNC:MAPT)
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 44)) isA p(HGNC:MAPT, pmod(Me, Lys))
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 67)) association p(HGNC:MAPT)
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 67)) isA p(HGNC:MAPT, pmod(Me, Lys))
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 190)) association p(HGNC:MAPT)
pmid:24869773 p(HGNC:MAPT, pmod(Me, Lys, 190)) isA p(HGNC:MAPT, pmod(Me, Lys))
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 163)) association p(HGNC:MAPT)
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 163)) partOf a(HBP:"proline-rich domain")
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 174)) association p(HGNC:MAPT)
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 174)) partOf a(HBP:"proline-rich domain")
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 180)) association p(HGNC:MAPT)
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 180)) partOf a(HBP:"proline-rich domain")
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 254)) association p(HGNC:MAPT)
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 254)) partOf p(HBP:"tubulin-binding repeat 1")
pmid:22033876 p(HGNC:MAPT, pmod(Ub, Lys, 254)) association p(HGNC:MAPT)
pmid:8391280 p(HGNC:MAPT, pmod(Ub, Lys, 254)) positiveCorrelation a(HBP:"paired helical filaments")
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 267)) association p(HGNC:MAPT)
pmid:22033876 p(HGNC:MAPT, pmod(Me, Lys, 267)) partOf p(HBP:"tubulin-binding repeat 1")
pmid:23943618 complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2))
pmid:23943618 complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:22764226 act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me))
pmid:22764226 act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me))
pmid:22764226 act(a(CHEBI:"L-dopa")) increases a(HBP:"Tau epitope, PHF1")
pmid:22764226 act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)")
pmid:22764226 act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)")
pmid:22764226 act(a(CHEBI:"L-dopa")) increases a(CHEBI:homocysteine)
pmid:22764226 act(a(CHEBI:"L-dopa")) decreases p(MGI:Ppp2ca, pmod(Me))
pmid:22764226 a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa"))
pmid:22764226 a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa"))
pmid:22764226 p(MGI:Ppp2ca, pmod(Me)) negativeCorrelation a(HBP:"Tau epitope, PHF1")
pmid:25143394 p(MGI:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation))
pmid:25681682 bp(MESH:"Body Mass Index") negativeCorrelation p(HGNC:AGER)
pmid:24183963 p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:24183963 p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:25987199 act(p(HGNC:GLP1R)) decreases bp(MESH:"Oxidative Stress")
pmid:25987199 act(p(HGNC:GLP1R)) increases act(a(GO:mitochondrion))
pmid:23531502 a(CHEBI:cinnamaldehyde) decreases p(HBP:"KXGS motif")
pmid:23531502 a(CHEBI:cinnamaldehyde) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:23531502 a(CHEBI:cinnamaldehyde) causesNoChange bp(GO:"microtubule polymerization")
pmid:23531502 a(CHEBI:cinnamaldehyde) decreases act(a(CHEBI:"hydrogen peroxide"))
pmid:23531502 p(HBP:"KXGS motif") positiveCorrelation p(HBP:"VQIVYK motif")
pmid:25031639 p(HBP:"KXGS motif") increases a(GO:"neurofibrillary tangle")
pmid:23531502 a(CHEBI:"(-)-epicatechin") decreases p(HBP:"KXGS motif")
pmid:23531502 a(CHEBI:"(-)-epicatechin") decreases bp(GO:"neurofibrillary tangle assembly")
pmid:23531502 a(CHEBI:"(-)-epicatechin") decreases act(a(CHEBI:"hydrogen peroxide"))
pmid:23531502 a(CHEBI:"(-)-epicatechin") increases complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein))
pmid:23531502 complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) decreases act(a(CHEBI:acrolein))
pmid:23531502 act(a(CHEBI:acrolein)) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:17082178 a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle")
pmid:23531502 act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:23531502 act(a(CHEBI:acrolein)) decreases a(MESH:Neurons)
pmid:23531502 act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26655600 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(Ph))
pmid:26655600 p(HBP:"Tau isoform C (410 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation))
pmid:26655600 p(HBP:"Tau isoform D (383 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"Tau isoform E (412 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"Tau isoform D (383 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"Tau isoform E (412 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"Tau isoform B (381 aa)", pmod(Ph)) increases bp(GO:"neurofibrillary tangle assembly")
pmid:26655600 p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly")
pmid:26304819 a(CHEBI:glyceraldehyde) decreases bp(GO:"canonical glycolysis")
pmid:26304819 a(CHEBI:glyceraldehyde) increases r(HGNC:GAPDH)
pmid:26304819 a(CHEBI:glyceraldehyde) increases bp(GO:"apoptotic process")
pmid:26304819 a(CHEBI:glyceraldehyde) increases a(HBP:"GA-AGE")
pmid:26304819 a(CHEBI:glyceraldehyde) decreases p(HGNC:APP, frag("672_713"))
pmid:26304819 a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT)
pmid:26304819 a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:26304819 a(CHEBI:glyceraldehyde) increases p(HGNC:VEGFA)
pmid:26304819 a(CHEBI:glyceraldehyde) increases p(HGNC:TGFB1)
pmid:19251756 bp(GO:"canonical glycolysis") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:26304819 r(HGNC:GAPDH) association bp(GO:"apoptotic process")
pmid:26304819 a(HBP:"GA-AGE") isA a(CHEBI:"advanced glycation end-product")
pmid:26095350 a(CHEBI:"D-ribose") increases a(CHEBI:"advanced glycation end-product")
pmid:26095350 a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214))
pmid:26095350 a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:26095350 a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396))
pmid:26095350 a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 214))
pmid:28176663 a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214))
pmid:26095350 a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:28176663 a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:26095350 a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:28176663 a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:26095350 a(CHEBI:"D-ribose") increases p(MGI:Camk2b, pmod(Ph, Thr, 287))
pmid:26095350 a(CHEBI:"D-ribose") decreases p(MGI:Camk2b, pmod(Ph, Thr, 306))
pmid:19517062 a(CHEBI:"D-ribose") increases p(HBP:"Tau aggregates")
pmid:19517062 a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(HBP:glycation))
pmid:28176663 a(CHEBI:"D-ribose") increases a(HBP:"advanced glycation end product")
pmid:26095350 p(MGI:Mapt, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose")
pmid:26095350 p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose")
pmid:26095350 p(MGI:Camk2b, pmod(Ph, Thr, 287)) increases act(p(MGI:Camk2b))
pmid:26095350 p(MGI:Camk2b, pmod(Ph, Thr, 306)) decreases act(p(MGI:Camk2b))
pmid:22798221 a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 404))
pmid:22798221 a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 198))
pmid:22798221 a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 199))
pmid:22798221 a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 202))
pmid:22798221 a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 231))
pmid:22798221 a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:22798221 a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 205))
pmid:22798221 a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product")
pmid:22798221 a(CHEBI:methylglyoxal) increases p(HGNC:AGER)
pmid:19251756 a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase"))
pmid:17082178 a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle")
pmid:22798221 act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404))
pmid:22798221 act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198))
pmid:22798221 act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199))
pmid:22798221 act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202))
pmid:22798221 act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231))
pmid:22798221 act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:22798221 act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205))
pmid:19251756 act(p(INTERPRO:"Triosephosphate isomerase")) increases rxn(reactants(a(CHEBI:"dihydroxyacetone phosphate")), products(a(CHEBI:"D-glyceraldehyde 3-phosphate")))
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase") partOf bp(GO:"canonical glycolysis")
pmid:19251756 act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(HBP:Neurodegeneration)
pmid:19251756 act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal)
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase"))
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO))
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase"))
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO))
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) association p(HGNC:MAPT)
pmid:19251756 p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO)))
pmid:19251756 complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:19251756 complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) partOf a(GO:"neurofibrillary tangle")
pmid:16630055 p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:22833681 p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:22833681 p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:22833681 p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22833681 p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:22833681 p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:22833681 p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau aggregates")
pmid:19732809 p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:16630055 path(MESH:Fasting) decreases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation"))
pmid:16630055 path(MESH:Fasting) increases p(MGI:Mapt, pmod(Ph))
pmid:16630055 path(MESH:Fasting) negativeCorrelation a(CHEBI:glucose)
pmid:12578227 p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:12578227 p(HGNC:TGM1) isA p(ECCODE:"2.3.2.13")
pmid:12578227 r(HBP:"TGM2 Isoform 3 (349 aa)") isA r(HGNC:TGM2)
pmid:12578227 p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:9099822 act(p(HGNC:TGM2)) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:12578227 p(HGNC:TGM2) isA p(ECCODE:"2.3.2.13")
pmid:10537045 p(HGNC:TGM2) positiveCorrelation p(HGNC:MAPT)
pmid:10537045 p(HGNC:TGM2) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2))
pmid:10537045 act(p(HGNC:TGM2)) association a(HBP:"microtubule-binding region")
pmid:11089576 act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive")
pmid:11089576 act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:11738469 act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:8985134 act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:11738469 act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:8985134 act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:10537045 complex(p(HGNC:MAPT), p(HGNC:TGM2)) positiveCorrelation a(CHEBI:"calcium(2+)")
pmid:10537045 a(HBP:maitotoxin) increases a(CHEBI:"calcium(2+)")
pmid:10537045 a(HBP:maitotoxin) increases act(p(HGNC:TGM2))
pmid:22057784 p(HGNC:MAPT, pmod(NO, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain")
pmid:17768677 p(MGI:Mapt, pmod(HBP:nitration, Tyr, 488)) causesNoChange act(p(MGI:Mapt))
pmid:17768677 p(MGI:Mapt, pmod(HBP:nitration, Tyr, 507)) partOf a(MESH:Brain)
pmid:16816118 a(CHEBI:linsidomine) increases a(CHEBI:peroxynitrite)
pmid:16816118 a(CHEBI:linsidomine) decreases act(p(HBP:"20 S Proteasome"))
pmid:16816118 p(RGD:Mapt, pmod(HBP:nitration)) negativeCorrelation act(p(HBP:"20 S Proteasome"))
pmid:27796283 act(p(HGNC:RHOA)) decreases bp(GO:"dendritic spine development")
pmid:27796283 act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines")
pmid:27796283 act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA))
pmid:27796283 bp(GO:"dendritic spine development") positiveCorrelation a(MESH:"Dendritic Spines")
pmid:27796283 p(HGNC:TIAM1, pmod(Ph)) increases act(p(HGNC:RAC1))
pmid:27796283 p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) increases act(p(HBP:"Kalirin 7"))
pmid:27796283 act(p(HBP:"Kalirin 7")) increases act(p(HGNC:RAC1))
pmid:27796283 p(HGNC:CAMK1) increases p(HGNC:ARHGEF7, pmod(Ph, Ser, 516))
pmid:27796283 p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) increases act(p(HGNC:ARHGEF7))
pmid:27796283 act(p(HGNC:ARHGEF7)) increases act(p(HGNC:RAC1))
pmid:27796283 complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2))
pmid:27796283 act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines")
pmid:27796283 act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA))
pmid:27796283 act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA))
pmid:27796283 p(HGNC:CAMKV) regulates bp(GO:"neuron-neuron synaptic transmission")
pmid:27796283 p(HGNC:CAMKV) association bp(MESH:"Long-Term Potentiation")
pmid:27796283 complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA))
pmid:27796283 p(HGNC:CAMKV, pmod(Ph, Thr, 345)) decreases act(p(HGNC:CAMKV))
pmid:29121589 complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) increases p(HGNC:NFE2L2, pmod(UbPoly))
pmid:29121589 p(HGNC:CUL3) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2))
pmid:29121589 p(HGNC:NFE2L2, pmod(UbPoly)) increases deg(p(HGNC:NFE2L2))
pmid:29121589 p(HGNC:NFE2L2, pmod(Ph)) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph)))
pmid:29121589 p(HGNC:BTRC) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph)))
pmid:29121589 p(HGNC:BTRC) isA p(ECCODE:"2.3.2.27")
pmid:29121589 complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) increases p(HGNC:NFE2L2, pmod(UbPoly))
pmid:29121589 p(HGNC:DPYSL2, pmod(Ph)) negativeCorrelation a(CHEBI:"dimethyl fumarate")
pmid:24401760 a(HBP:Astrogliosis) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:29121589 r(MGI:Il1b) biomarkerFor bp(GO:"inflammatory response")
pmid:29121589 r(MGI:Nos2) biomarkerFor bp(GO:"inflammatory response")
pmid:27807169 p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5))
pmid:27807169 p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine")
pmid:27807169 p(RGD:Cdk5r2) positiveCorrelation a(GO:synapse)
pmid:21489990 act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 396))
pmid:21489990 act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 404))
pmid:21489990 act(p(RGD:Cdk5)) directlyDecreases act(p(RGD:Ppp1ca))
pmid:7514173 a(CHEBI:"glycerol 2-phosphate") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:7514173 a(CHEBI:"diethyl pyrocarbonate") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:7514173 a(CHEBI:"pyridoxal 5'-phosphate") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:7514173 a(CHEBI:Phenylglyoxal) decreases act(p(HGNC:GSK3B), ma(kin))
pmid:7514173 a(CHEBI:"poly(lysine) polymer") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:7514173 a(CHEBI:"sodium chloride") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:7514173 a(CHEBI:"sodium fluoride") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:7514173 a(CHEBI:"manganese(II) chloride") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:7514173 a(CHEBI:"calcium dichloride") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Thr, 217)) positiveCorrelation p(FPLX:PKA)
pmid:17078951 p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217)))
pmid:22072628 p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf p(HBP:"proline-rich region 2", pmod(Ph))
pmid:9089387 p(FPLX:PDH, pmod(Ph)) negativeCorrelation act(p(FPLX:PDH, pmod(Ph)))
pmid:9089387 act(p(FPLX:PDH, pmod(Ph))) negativeCorrelation p(FPLX:PDH, pmod(Ph))
pmid:22102280 a(HBP:tideglusib) decreases act(p(HGNC:GSK3B), ma(kin))
pmid:22102280 a(CHEBI:hypothemycin) decreases act(p(HGNC:GSK3B), ma(kin))
pmid:22102280 a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin))
pmid:10998059 a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin))
pmid:10998059 a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(Ph))
pmid:10998059 a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin))
pmid:10998059 a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph))
pmid:11013232 a(HBP:indirubin) decreases act(p(HGNC:GSK3B), ma(kin))
pmid:10998059 act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Ppp1r1b, pmod(Ph))
pmid:26400044 act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Wasf1, pmod(Ph))
pmid:26400044 act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Dpysl2, pmod(Ph))
pmid:24808823 p(MGI:Cdk5) negativeCorrelation bp(GO:learning)
pmid:27087442 p(MGI:Cdk5) negativeCorrelation p(MGI:Cdk5r1)
pmid:27087442 p(MGI:Cdk5) negativeCorrelation act(p(HBP:RAC1b))
pmid:27087442 p(MGI:Cdk5) negativeCorrelation path(MESH:Cognition)
pmid:27087442 p(MGI:Cdk5) negativeCorrelation act(a(MESH:Neurons))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 175))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 176))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 178))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 195))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8")
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 217))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 220))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 239))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 400))
pmid:14642273 act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 403))
pmid:8702879 p(HGNC:SYN1, pmod(Ph, Ser, 551)) negativeCorrelation act(p(HGNC:SYN1))
pmid:8702879 act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 551))
pmid:8702879 act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 62))
pmid:8702879 act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 67))
pmid:8702879 p(HGNC:SYN1, pmod(Ph, Ser, 62)) negativeCorrelation act(p(HGNC:SYN1))
pmid:8702879 p(HGNC:SYN1, pmod(Ph, Ser, 67)) negativeCorrelation act(p(HGNC:SYN1))
pmid:26400044 p(MGI:Wasf1, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph)))
pmid:26400044 p(MGI:Dpysl2, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph)))
pmid:26400044 complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) association path(MESH:"Plaque, Amyloid")
pmid:8726973 a(HBP:isopentanyladenine) decreases act(p(HGNC:CDK5))
pmid:8726973 a(HBP:olomoucine) decreases act(p(HGNC:CDK5))
pmid:18239272 p(HGNC:CSNK1D) increases p(HGNC:MAPT, pmod(Ph))
pmid:25673844 p(HGNC:CSNK1D) isA p(FPLX:CSNK1)
pmid:18239272 p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 198))
pmid:18239272 p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 199))
pmid:18239272 p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:18239272 p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:18239272 p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:18239272 p(HGNC:TTBK1) association a(HBP:pretangles)
pmid:20096481 p(HGNC:TTBK1) increases act(p(HGNC:CDK5))
pmid:20096481 p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(kin))
pmid:21548880 p(HGNC:TTBK1) increases p(HGNC:CDK5R1)
pmid:21548880 p(HGNC:TTBK1) positiveCorrelation act(p(ECCODE:"3.4.22.52"))
pmid:21548880 p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2B)
pmid:21548880 p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2D)
pmid:25673844 p(HGNC:TTBK1) isA p(HBP:"CK1 superfamily")
pmid:25673844 p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42))
pmid:25673844 p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45))
pmid:25673844 p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47))
pmid:25673844 p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80))
pmid:25673844 p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81))
pmid:25673844 p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84))
pmid:25473830 p(HGNC:TTBK1) directlyIncreases p(HGNC:TARDBP, pmod(Ph))
pmid:25473830 p(HGNC:TTBK1) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm))
pmid:23687953 act(p(HGNC:TTBK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 197))
pmid:20096481 g(DBSNP:rs2651206) association path(MESH:"Alzheimer Disease")
pmid:21548880 g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:20096481 g(DBSNP:rs2651206) association g(HGNC:TTBK1)
pmid:21548880 g(DBSNP:rs2651206) isA g(HGNC:TTBK1)
pmid:20096481 g(DBSNP:rs10807287) association path(MESH:"Alzheimer Disease")
pmid:20096481 g(DBSNP:rs10807287) association g(HGNC:TTBK1)
pmid:20096481 g(DBSNP:rs7764257) association path(MESH:"Alzheimer Disease")
pmid:20096481 g(DBSNP:rs7764257) association g(HGNC:TTBK1)
pmid:20096481 g(HGNC:TTBK1) association g(DBSNP:rs2651206)
pmid:20096481 g(HGNC:TTBK1) association g(DBSNP:rs10807287)
pmid:20096481 g(HGNC:TTBK1) association g(DBSNP:rs7764257)
pmid:2820993 act(p(FPLX:CSNK2)) increases act(p(HGNC:GSK3B), ma(kin))
pmid:21548880 p(HGNC:TTBK2, var("p.Tyr448*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11")
pmid:21548880 p(HGNC:TTBK2, var("p.Tyr448*")) increases p(HGNC:TTBK2)
pmid:21548880 p(HGNC:TTBK2, var("p.Tyr448*")) decreases act(p(HGNC:TTBK2), ma(kin))
pmid:21548880 path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Tyr448*"))
pmid:21548880 path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Asp449*"))
pmid:21548880 path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Glu450*"))
pmid:21548880 p(HGNC:TTBK2, var("p.Asp449*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11")
pmid:21548880 p(HGNC:TTBK2, var("p.Asp449*")) increases p(HGNC:TTBK2)
pmid:21548880 p(HGNC:TTBK2, var("p.Asp449*")) decreases act(p(HGNC:TTBK2), ma(kin))
pmid:21548880 p(HGNC:TTBK2, var("p.Glu450*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11")
pmid:21548880 p(HGNC:TTBK2, var("p.Glu450*")) increases p(HGNC:TTBK2)
pmid:21548880 p(HGNC:TTBK2, var("p.Glu450*")) decreases act(p(HGNC:TTBK2), ma(kin))
pmid:21548880 act(p(ECCODE:"3.4.22.52")) positiveCorrelation p(HGNC:TTBK1)
pmid:21548880 p(HGNC:GRIN2D) negativeCorrelation p(HGNC:TTBK1)
pmid:25673844 p(HGNC:VRK2) isA p(HBP:"CK1 superfamily")
pmid:25673844 p(HGNC:VRK3) isA p(HBP:"CK1 superfamily")
pmid:25673844 p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1)
pmid:25673844 p(HGNC:CSNK1E) isA p(FPLX:CSNK1)
pmid:25673844 p(HGNC:CSNK1G1) isA p(FPLX:CSNK1)
pmid:25673844 p(HGNC:CSNK1G2) isA p(FPLX:CSNK1)
pmid:25673844 p(HGNC:CSNK1G3) isA p(FPLX:CSNK1)
pmid:25673844 p(HGNC:SV2A, pmod(Ph, Thr, 84)) association p(HGNC:SYT1)
pmid:25673844 p(HGNC:SYT1) association p(HGNC:SV2A, pmod(Ph, Thr, 84))
pmid:27607061 surf(p(HGNC:GRIK2)) negativeCorrelation act(p(HGNC:RAB5A))
pmid:26323690 p(HGNC:KIF2A, pmod(Ph)) negativeCorrelation bp(GO:"microtubule depolymerization")
pmid:26323690 act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport")
pmid:26323690 bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1))
pmid:26323690 p(HGNC:CEP164) association p(HGNC:TTBK2)
pmid:26323690 p(HGNC:CEP164) positiveCorrelation act(p(HGNC:TTBK2))
pmid:26323690 p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3))
pmid:26323690 p(HGNC:MAPRE1) association p(HGNC:TTBK2)
pmid:26323690 p(HGNC:CEP164, pmod(Ph)) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3))
pmid:26323690 complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(Ph))
pmid:26323690 p(HGNC:DVL3) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3))
pmid:24808823 p(MGI:Ttbk1) negativeCorrelation bp(GO:learning)
pmid:24808823 p(MGI:Ttbk1) increases a(HBP:pretangles)
pmid:24808823 p(MGI:Ttbk1) increases bp(GO:"neuron death")
pmid:24808823 surf(p(MGI:Grin2b)) positiveCorrelation bp(GO:learning)
pmid:11943212 p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:11943212 p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:11943212 p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:11943212 p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:11943212 p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:11943212 p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 396))
pmid:11943212 p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:11943212 p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:11943212 p(HGNC:MAPT, pmod(Ph, Thr, 396)) partOf p(HBP:"Tau epitope, AD2")
pmid:26751493 p(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1")
pmid:26751493 p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle")
pmid:11943212 p(HGNC:MARK4, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:11943212 p(HGNC:MARK4, pmod(Ph)) positiveCorrelation a(HBP:"granulovacuolar degeneration")
pmid:22692785 p(HGNC:MARK4) negativeCorrelation p(HBP:PrPSc)
pmid:23666762 p(HGNC:MARK4) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:22156579 p(HGNC:MARK4) increases a(HBP:"Tau epitope, 12E8")
pmid:22156579 p(HGNC:MARK4) negativeCorrelation act(p(RGD:Dlg4))
pmid:22156579 p(HGNC:MARK4) negativeCorrelation p(RGD:Gria1)
pmid:22156579 p(HGNC:MARK4) negativeCorrelation a(GO:"dendritic spine")
pmid:22156579 p(HGNC:MARK4) negativeCorrelation a(GO:synapse)
pmid:22692785 p(HBP:PrPSc) negativeCorrelation p(HGNC:MARK4)
pmid:22692785 p(HBP:"PrP106-126") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22156579 p(INTERPRO:"Kinase associated domain 1 (KA1)") positiveCorrelation act(a(HBP:"amyloid-beta oligomers"))
pmid:22156579 act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22156579 act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356))
pmid:16973293 p(HBP:"MARK4 isoform 2 (688 aa)") positiveCorrelation bp(GO:"neuron development")
pmid:16973293 p(HBP:"MARK4 isoform 2 (688 aa)") isA p(HGNC:MARK4)
pmid:16973293 bp(GO:"neuron development") positiveCorrelation p(HBP:"MARK4 isoform 2 (688 aa)")
pmid:23666762 p(HBP:"Tau antibody, AGG5759") increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:23666762 p(HBP:"Tau antibody, Tau-13") increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:23666762 p(HBP:"CagA peptide") decreases act(p(HGNC:MARK4), ma(kin))
pmid:27094130 p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_713")))
pmid:27094130 act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_713")))
pmid:27094130 p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_711")))
pmid:27094130 act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_711")))
pmid:27094130 act(p(HGNC:DAPK1), ma(kin)) increases p(HGNC:APP, pmod(Ph, Thr, 668))
pmid:27068745 act(p(HGNC:DAPK1)) increases bp(GO:"neuron apoptotic process")
pmid:25899010 p(HGNC:DAPK1) positiveCorrelation a(HBP:Excitotoxicity)
pmid:25899010 p(HGNC:DAPK1) negativeCorrelation p(HGNC:PIN1)
pmid:27795443 act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND))
pmid:27795443 act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process")
pmid:24853415 p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(Ph, Ser, 71))
pmid:24853415 p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:23948915 p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:24853415 p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:23948915 p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:24853415 p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:23948915 p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:24853415 p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT)
pmid:21311567 p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1))
pmid:21311567 p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2))
pmid:21311567 p(HGNC:DAPK1) decreases bp(GO:"microtubule polymerization")
pmid:27094130 p(HGNC:DAPK1, frag("637_1423")) association p(HGNC:APP)
pmid:27094130 p(HGNC:DAPK1, frag("637_1423")) partOf p(HGNC:DAPK1)
pmid:27094130 p(HGNC:DAPK1, frag("848_1423")) association p(HGNC:APP)
pmid:27094130 p(HGNC:DAPK1, frag("848_1423")) partOf p(HGNC:DAPK1)
pmid:27094130 p(HGNC:DAPK1, frag("1271_1423")) association p(HGNC:APP)
pmid:27094130 p(HGNC:DAPK1, frag("1271_1423")) equivalentTo p(INTERPRO:"Death domain")
pmid:27094130 p(INTERPRO:"Death domain") equivalentTo p(HGNC:DAPK1, frag("1271_1423"))
pmid:27094130 p(INTERPRO:"Death domain") partOf p(HGNC:DAPK1)
pmid:27068745 p(HGNC:UNC5B) increases act(p(HGNC:DAPK1))
pmid:27068745 p(HGNC:UNC5B) positiveCorrelation act(p(FPLX:PPP2), ma(kin))
pmid:27068745 p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process")
pmid:27068745 p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process")
pmid:27068745 p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1))
pmid:27068745 p(HGNC:CALML5) decreases p(HGNC:UNC5C, var("p.Thr835Met"))
pmid:27068745 act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met"))
pmid:27068745 act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5))
pmid:27068745 act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1))
pmid:27068745 act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK))
pmid:27068745 act(p(HGNC:MAP3K5)) association p(HGNC:CASP3)
pmid:27068745 p(ECCODE:"1.6.3.1") positiveCorrelation act(p(FPLX:JNK))
pmid:27795443 act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process")
pmid:27795443 act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1))
pmid:27133022 p(HBP:"DAPK, basic loop (BL) motif") partOf p(HGNC:DAPK2)
pmid:27133022 p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2))
pmid:27133022 p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(FPLX:CALM))
pmid:27133022 act(p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif")
pmid:25995053 p(MGI:Dapk1) association p(MGI:Mapt)
pmid:25995053 p(MGI:Dapk1) directlyIncreases complex(p(MGI:Dapk1), p(MGI:Mapt))
pmid:25995053 p(MGI:Dapk1) increases p(MGI:Mapt, pmod(Ph, Ser, 262))
pmid:25995053 complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process")
pmid:25995053 p(MGI:Mapt, pmod(Ph, Ser, 262)) decreases a(GO:"dendritic spine")
pmid:25125464 p(MGI:Mapt, pmod(Ph, Ser, 262)) positiveCorrelation p(MGI:Crh)
pmid:24853415 p(HGNC:PIN1, pmod(Ph, Ser, 71)) decreases act(p(HGNC:PIN1))
pmid:24853415 p(HGNC:PIN1, pmod(Ph, Ser, 71)) positiveCorrelation p(HGNC:MAPT)
pmid:22926167 p(HGNC:PIN1, pmod(Ph, Ser, 71)) negativeCorrelation p(HGNC:MAPT)
pmid:28137862 p(MGI:Dcaf1) association p(MGI:Dyrk1a)
pmid:28137862 p(MGI:Dcaf1) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a))
pmid:28137862 p(MGI:Dcaf1) association p(MGI:Hap1)
pmid:28137862 p(MGI:Dyrk1a) association p(MGI:Dcaf1)
pmid:28137862 p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a))
pmid:28137862 p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1)
pmid:29221819 p(MGI:Dyrk1a) positiveCorrelation a(HBP:"granular layer of cerebellar cortex")
pmid:29221819 p(MGI:Dyrk1a) positiveCorrelation a(HBP:"molecular layer of cerebellar cortex")
pmid:29221819 p(MGI:Dyrk1a) positiveCorrelation a(HBP:"Purkinje cell layer of cerebellar cortex")
pmid:29221819 p(MGI:Dyrk1a) positiveCorrelation bp(GO:"dendrite arborization")
pmid:29221819 p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence")
pmid:29221819 p(MGI:Dyrk1a) positiveCorrelation act(a(HBP:"cholinergic neuron"))
pmid:29221819 p(MGI:Dyrk1a) negativeCorrelation p(MGI:App)
pmid:29221819 p(MGI:Dyrk1a) negativeCorrelation a(CHEBI:"amyloid-beta")
pmid:29221819 p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202))
pmid:29221819 p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt)
pmid:28540658 p(MGI:Dyrk1a) decreases a(CHEBI:serotonin)
pmid:28540658 p(MGI:Dyrk1a) decreases a(CHEBI:dopamine)
pmid:28540658 p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline)
pmid:28775333 p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau")
pmid:28775333 p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau")
pmid:28775333 p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety)
pmid:28775333 p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory)
pmid:28137862 complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) negativeCorrelation p(MGI:Hap1)
pmid:28137862 p(MGI:Hap1) association p(MGI:Dcaf1)
pmid:28137862 p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a)
pmid:28137862 p(MGI:Hap1) negativeCorrelation complex(p(MGI:Dcaf1), p(MGI:Dyrk1a))
pmid:29221819 a(HBP:"granular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a)
pmid:29221819 a(HBP:"molecular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a)
pmid:29221819 a(HBP:"Purkinje cell layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a)
pmid:29221819 bp(GO:"dendrite arborization") positiveCorrelation p(MGI:Dyrk1a)
pmid:29221819 act(a(HBP:"cholinergic neuron")) positiveCorrelation p(MGI:Dyrk1a)
pmid:28884684 a(HBP:"ID-8") decreases act(p(HGNC:DYRK1B), ma(kin))
pmid:28884684 a(HBP:"ID-8") decreases act(p(HGNC:GSK3B), ma(kin))
pmid:28884684 a(HBP:"ID-8") decreases act(p(HGNC:DYRK1A), ma(kin))
pmid:28884684 a(HBP:"ID-8") decreases bp(GO:"neuron differentiation")
pmid:28884684 act(p(HGNC:DYRK1A), ma(kin)) positiveCorrelation bp(GO:"neuron differentiation")
pmid:28250274 p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME)
pmid:28632203 p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:28167836 act(p(HGNC:DYRK1A)) regulates a(HBP:Neurites)
pmid:28167836 act(p(HGNC:DYRK1A)) regulates a(GO:axon)
pmid:28250274 a(CHEBI:harmine) decreases p(HGNC:DYRK1A)
pmid:28250274 a(CHEBI:harmine) increases p(HGNC:MME)
pmid:29077046 a(CHEBI:harmine) increases complex(a(CHEBI:harmine), g(HGNC:DYRK1A))
pmid:28775333 p(MGI:Mef2d) increases r(MGI:Dyrk1a)
pmid:28775333 p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(kin))
pmid:28632203 composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease")
pmid:28167836 p(HBP:"NP_001387.2:p.Arg205del") decreases act(p(HGNC:DYRK1A))
pmid:28167836 p(HBP:"NP_001387.2:p.Arg205del") positiveCorrelation path(MESH:"Autism Spectrum Disorder")
pmid:28167836 p(HBP:"NP_001387.2:p.Glu239del") decreases act(p(HGNC:DYRK1A))
pmid:28167836 p(HBP:"NP_001387.2:p.Glu239del") positiveCorrelation path(MESH:"Autism Spectrum Disorder")
pmid:28877763 p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 301))
pmid:28877763 p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18))
pmid:25331948 p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18))
pmid:28877763 p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:25331948 p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:28877763 p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404))
pmid:25331948 p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404))
pmid:28877763 p(MGI:Syk) positiveCorrelation p(MGI:Mapt)
pmid:25331948 p(MGI:Syk) positiveCorrelation a(CHEBI:"amyloid-beta")
pmid:25331948 p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202))
pmid:28877763 p(MGI:Mapt, pmod(Ph, Ser, 301)) positiveCorrelation p(MGI:Syk)
pmid:28877763 p(MGI:Syk, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:28877763 p(MGI:Syk, pmod(Ph)) partOf a(HBP:"dystrophic neurite")
pmid:28877763 p(HGNC:SYK, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:28877763 p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18))
pmid:18070606 p(RGD:Syk) increases p(RGD:Mapt, pmod(Ph, Tyr, 18))
pmid:26501932 a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(GO:"synaptic vesicle")
pmid:26501932 a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") association a(HBP:"GVD bodies")
pmid:26501932 a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(HBP:pretangles)
pmid:26501932 a(HBP:"GVD bodies") association a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate")
pmid:25331948 a(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:25331948 a(HBP:"BAY61-3606") directlyDecreases act(p(HGNC:SYK))
pmid:28176663 a(HBP:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(kin))
pmid:28176663 a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
pmid:28176663 a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 214))
pmid:28176663 a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:25987199 act(a(HBP:"advanced glycation end product")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:25987199 act(a(HBP:"advanced glycation end product")) negativeCorrelation act(p(MGI:Glp1r))
pmid:26118667 p(HBP:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1)
pmid:26118667 p(HBP:"CDK5R1 p25") equivalentTo p(HGNC:CDK5R1, frag("99_307"))
pmid:26118667 p(HBP:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:26118667 p(HBP:"CDK5R1 p25") positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:27087442 p(HBP:"CDK5R1 p25") positiveCorrelation p(HBP:"Tau epitope, AT8")
pmid:14642273 p(HBP:"CDK5R1 p25") directlyIncreases act(p(MGI:Cdk5), ma(kin))
pmid:14642273 p(HBP:"CDK5R1 p25") increases p(HBP:"Tau aggregates")
pmid:26118667 p(HGNC:CDK5R1, frag("99_307")) equivalentTo p(HBP:"CDK5R1 p25")
pmid:26118667 a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 202))
pmid:26118667 a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 205))
pmid:26118667 a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 262))
pmid:26118667 a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 231))
pmid:26118667 a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 422))
pmid:26118667 a(HBP:"Chronic cerebral hypoperfusion") increases p(HBP:"CDK5R1 p25")
pmid:26118667 a(HBP:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB)
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:26118667 m(MIRBASE:"rno-mir-195") increases complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195"))
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:App)
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Bace1)
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation a(CHEBI:"amyloid-beta")
pmid:26118667 m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Cdk5r1)
pmid:26118667 complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) decreases r(RGD:Cdk5r1)
pmid:26118667 complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) decreases m(MIRBASE:"rno-mir-195")
pmid:26118667 p(RGD:App) negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:26118667 p(RGD:Bace1) negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:26118667 p(INTERPRO:"Peptidase C2, calpain, catalytic domain") positiveCorrelation act(p(RGD:Cdk5r1))
pmid:26118667 act(p(RGD:Cdk5r1)) positiveCorrelation p(INTERPRO:"Peptidase C2, calpain, catalytic domain")
pmid:26118667 p(RGD:Cdk5r1) negativeCorrelation m(MIRBASE:"rno-mir-195")
pmid:27087442 path(MESH:Cognition) negativeCorrelation p(MGI:Cdk5)
pmid:25987199 act(p(MGI:Glp1r)) increases act(p(MGI:Ppargc1a))
pmid:25987199 act(p(MGI:Glp1r)) decreases act(p(MGI:Gsk3b), ma(kin))
pmid:25987199 act(p(MGI:Glp1r)) decreases p(MGI:Mapt, pmod(HBP:hyperphosphorylation))
pmid:25987199 act(p(MGI:Glp1r)) negativeCorrelation act(a(HBP:"advanced glycation end product"))
pmid:25143394 p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1ca)
pmid:25143394 p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp2ca)
pmid:25143394 p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1cb)
pmid:23134599 p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(RGD:Ppp2ca)
pmid:25125464 p(MGI:Crhr1) positiveCorrelation p(HBP:"Tau epitope, AT8")
pmid:25125464 p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau epitope, PHF1")
pmid:25125464 p(MGI:Crhr1) positiveCorrelation p(MGI:Mapk8)
pmid:25125464 p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau aggregates")
pmid:25125464 p(MGI:Mapt, pmod(Ph, Ser, 422)) positiveCorrelation p(MGI:Crh)
pmid:25125464 p(MGI:Mapk8) positiveCorrelation p(MGI:Crhr1)
pmid:25125464 a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn)
pmid:19459590 p(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:19459590 p(HBP:"Tau epitope, CP13") decreases act(p(HGNC:MAPT))
pmid:23294633 a(HBP:"Tau epitope, AT100") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:22833681 p(HGNC:MAPT, pmod(Ph, Thr, 214)) partOf a(HBP:"Tau epitope, AT100")
pmid:22833681 p(HGNC:MAPT, pmod(Ph, Ser, 212)) partOf a(HBP:"Tau epitope, AT100")
pmid:22833681 a(HBP:"Thiamet G") directlyDecreases act(p(ECCODE:"3.2.1.169"))
pmid:22833681 act(p(ECCODE:"3.2.1.169")) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation"))
pmid:23294633 p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:23294633 p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) increases act(p(MGI:Gsk3b), ma(kin))
pmid:23294633 p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:23294633 p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) increases act(p(MGI:Gsk3b), ma(kin))
pmid:22002427 p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*"))
pmid:22002427 p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation a(GO:"neurofibrillary tangle")
pmid:24033439 p(HBP:"Tau epitope, PHF1") biomarkerFor path(MESH:"Alzheimer Disease")
pmid:24033439 p(HBP:"Tau epitope, PHF1") increases a(GO:"neurofibrillary tangle")
pmid:24251416 p(HGNC:MAPT, pmod(Ph, Ser, 352)) partOf p(HBP:"tubulin-binding repeat 4")
pmid:22156579 act(p(RGD:Dlg4)) negativeCorrelation p(HGNC:MARK4)
pmid:22156579 p(RGD:Gria1) negativeCorrelation p(HGNC:MARK4)
pmid:22941973 act(p(INTERPRO:"14-3-3 domain")) increases p(RGD:Mapt, pmod(Ph, Ser, 262))
pmid:22941973 act(p(INTERPRO:"14-3-3 domain")) decreases bp(GO:"microtubule polymerization")
pmid:22941973 act(p(INTERPRO:"14-3-3 domain")) increases deg(p(RGD:Syp))
pmid:22941973 act(p(INTERPRO:"14-3-3 domain")) negativeCorrelation a(CHEBI:paclitaxel)
pmid:23722080 a(CHEBI:"sodium azide") directlyDecreases a(GO:mitochondrion)
pmid:23722080 a(CHEBI:"sodium azide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide"))
pmid:23722080 composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"hydrogen peroxide")
pmid:23722080 composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"sodium azide")
pmid:23722080 composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases a(CHEBI:"glutamate(1-)")
pmid:23722080 composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 262))
pmid:23722080 composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 404))
pmid:23722080 composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Bace1)
pmid:23722080 composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(HBP:"CDK5R1 p25")
pmid:23722080 composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) decreases bp(GO:"cellular metabolic process")
pmid:23722080 composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 262))
pmid:23722080 composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 404))
pmid:23722080 composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) increases bp(GO:"cellular metabolic process")
pmid:22952452 p(HGNC:TRAK1) positiveCorrelation act(a(GO:mitochondrion))
pmid:22952452 p(HGNC:TRAK1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22952452 p(HGNC:TRAK1) negativeCorrelation p(HGNC:MARK1)
pmid:22952452 p(HGNC:RHOT1) positiveCorrelation act(a(GO:mitochondrion))
pmid:22952452 p(HGNC:RHOT1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22952452 p(HGNC:RHOT1) negativeCorrelation p(HGNC:MARK1)
pmid:23001711 p(HGNC:CHEK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
pmid:22072628 p(HBP:"proline-rich region 2", pmod(Ph)) positiveCorrelation bp(MESH:"Protein Conformation, alpha-Helical")
pmid:22072628 p(HGNC:MAPT, frag("235_324")) association bp(MESH:"Protein Conformation, alpha-Helical")
pmid:8226987 p(HGNC:MAPT, pmod(Ph, Ser, 261)) decreases act(p(HGNC:MAPT))
pmid:24401760 p(HGNC:ITPKB) positiveCorrelation path(MESH:"Plaque, Amyloid")
pmid:24401760 p(HGNC:ITPKB) partOf a(HBP:"dystrophic neurite")
pmid:24401760 p(MGI:Itpkb) increases bp(GO:"apoptotic process")
pmid:24401760 p(MGI:Itpkb) increases p(MGI:Bace1)
pmid:24401760 p(MGI:Itpkb) increases act(p(MGI:Bace1))
pmid:24401760 p(MGI:Itpkb) increases act(p(MGI:Map2k1))
pmid:24401760 p(MGI:Itpkb) increases act(p(MGI:Map2k2))
pmid:24401760 p(MGI:Itpkb) increases a(HBP:Astrogliosis)
pmid:24401760 p(MGI:Itpkb) increases p(HGNC:APP, frag("672_711"))
pmid:24401760 p(MGI:Itpkb) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:24401760 a(HBP:"SL-327") directlyDecreases p(MGI:Map2k1)
pmid:24401760 a(HBP:"SL-327") directlyDecreases p(MGI:Map2k2)
pmid:24401760 a(HBP:"SL-327") decreases a(CHEBI:"amyloid-beta")
pmid:23737518 a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Cdk5))
pmid:23737518 a(HBP:"LDN-193594") decreases a(HBP:"Tau epitope, PHF1")
pmid:23737518 a(HBP:"LDN-193594") decreases act(p(HBP:"CDK5R1 p25"))
pmid:23737518 a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Gsk3b))
pmid:23737518 a(HBP:"LDN-193594") isA a(HBP:diaminothiazole)
pmid:23737518 a(HBP:"LDN-193665") isA a(HBP:diaminothiazole)
pmid:23737518 a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Cdk5))
pmid:23737518 a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Gsk3b))
pmid:23737518 a(HBP:"LDN-213843") isA a(HBP:diaminothiazole)
pmid:23737518 a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Cdk5))
pmid:23737518 a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Gsk3b))
pmid:7667312 p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(HBP:"paired helical filaments")
pmid:7667312 a(HBP:"Thioflavin S") positiveCorrelation a(HBP:"paired helical filaments")
pmid:25672970 a(HBP:"C-30-27") directlyDecreases act(p(HGNC:KAT2B))
pmid:25672970 a(HBP:"C-30-27") increases path(MESH:Cognition)
pmid:25672970 act(p(HGNC:KAT2B)) positiveCorrelation p(FPLX:NFkappaB, pmod(Ac, Lys, 122))
pmid:25546293 p(HGNC:KAT2B) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49))
pmid:24686445 act(p(HGNC:KAT2B)) positiveCorrelation act(p(FPLX:ERK))
pmid:24686445 act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9))
pmid:25672970 p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) positiveCorrelation act(p(HGNC:KAT2B))
pmid:24844691 a(HBP:"Tubastatin A") directlyDecreases act(p(HGNC:HDAC6))
pmid:24844691 a(HBP:"Tubastatin A") decreases a(CHEBI:"amyloid-beta")
pmid:24844691 a(HBP:"Tubastatin A") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
pmid:24844691 a(HBP:"ACY-1215") directlyDecreases act(p(HGNC:HDAC6))
pmid:24844691 a(HBP:"ACY-1215") decreases a(CHEBI:"amyloid-beta")
pmid:25546293 p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) increases deg(p(HGNC:CTNNB1))
pmid:25546293 p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) increases deg(p(HGNC:CTNNB1))
pmid:25546293 p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) increases deg(p(HGNC:CTNNB1))
pmid:25546293 p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) decreases p(HGNC:CTNNB1, pmod(Ub))
pmid:25546293 p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) increases p(HGNC:CTNNB1, loc(GO:membrane))
pmid:25546293 p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) negativeCorrelation act(p(HGNC:HDAC6))
pmid:25546293 a(CHEBI:vorinostat) directlyDecreases act(p(HGNC:HDAC6))
pmid:25546293 a(CHEBI:vorinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49))
pmid:25546293 a(HBP:crebinostat) directlyDecreases act(p(HGNC:HDAC6))
pmid:25546293 a(HBP:crebinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49))
pmid:27917100 a(HBP:ST7612AA1) directlyDecreases act(p(FPLX:HDAC))
pmid:26890116 a(HBP:"Biphenyl-4-yl-acrylohydroxamoc acids") directlyDecreases act(p(FPLX:HDAC))
pmid:18558669 a(HBP:Trithiocarbonates) directlyDecreases act(p(HGNC:HDAC6))
pmid:29540553 p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(Ac, Lys, 174))
pmid:29540553 p(MGI:Sirt1) positiveCorrelation a(GO:"neuron to neuron synapse")
pmid:29540553 p(MGI:Sirt1) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:29540553 a(GO:"neuron to neuron synapse") positiveCorrelation p(MGI:Sirt1)
pmid:29540553 p(MGI:Sirt3) negativeCorrelation p(HGNC:APP, frag("672_713"))
pmid:29540553 p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT)
pmid:29540553 p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT, pmod(Ac))
pmid:29540553 p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:27550730 a(HBP:"CM-414") directlyDecreases act(p(MGI:Pde5a))
pmid:27550730 a(HBP:"CM-414") directlyDecreases act(p(ECCODE:"3.5.1.98"))
pmid:27550730 a(HBP:"CM-414") decreases a(CHEBI:"amyloid-beta")
pmid:27550730 a(HBP:"CM-414") decreases p(MGI:Mapt, pmod(Ph))
pmid:27550730 a(HBP:"CM-414") decreases act(p(MGI:Gsk3b), ma(kin))
pmid:27550730 act(p(HGNC:PDE5A)) negativeCorrelation act(p(FPLX:CREB))
pmid:29559585 p(MGI:Gapdh, pmod(NO)) increases act(p(MGI:Ep300))
pmid:29559585 p(MGI:Gapdh, pmod(NO)) positiveCorrelation p(MGI:Mapt, pmod(Ac, Lys, 280))
pmid:29559585 act(p(MGI:Ep300)) positiveCorrelation p(MGI:Sirt1, pmod(NO))
pmid:29559585 p(MGI:Sirt1, pmod(NO)) positiveCorrelation act(p(MGI:Ep300))
pmid:29559585 p(MGI:Sirt1, pmod(NO)) increases act(p(MGI:Sirt1))
pmid:29559585 p(MGI:Mapt, pmod(Ac, Lys, 280)) positiveCorrelation p(MGI:Gapdh, pmod(NO))
pmid:29559585 a(HBP:CGP3466B) decreases p(MGI:Gapdh, pmod(NO))
pmid:28855586 composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 163))
pmid:28855586 composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 280))
pmid:28855586 composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 281))
pmid:28855586 composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 369))
pmid:28855586 composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases p(HGNC:MAPT, pmod(Ph))
pmid:28855586 composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases act(p(HGNC:MAPT))
pmid:28855586 composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) negativeCorrelation act(a(CHEBI:"amyloid-beta"))
pmid:28287136 p(HGNC:MAPT, var("p.Lys280Gln")) increases a(HBP:"Tau aggregates")
pmid:28002468 p(HGNC:MAP4, frag("992_999")) equivalentTo p(HBP:"VQIINK motif")
pmid:28002468 p(HGNC:MAP4, frag("1023_1030")) equivalentTo p(HBP:"VQIINK motif")
pmid:28002468 p(HGNC:MAP2, frag("332_339")) equivalentTo p(HBP:"VQIVYK motif")
pmid:28002468 a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAPT, pmod(Ac))
pmid:28002468 a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(Ac))
pmid:27041503 p(HGNC:WWC1) negativeCorrelation bp(MESH:"Long-Term Potentiation")
pmid:26390242 a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300))
pmid:26390242 a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174))
pmid:26390242 a(CHEBI:salsalate) decreases p(HGNC:MAPT)
pmid:26390242 a(CHEBI:salsalate) positiveCorrelation a(MESH:Hippocampus)
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 225)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 317)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 317)) partOf a(HBP:"microtubule-binding region")
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 331)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 331)) partOf a(HBP:"microtubule-binding region")
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 343)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 343)) partOf a(HBP:"microtubule-binding region")
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 347)) isA p(HGNC:MAPT, pmod(Ac))
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 347)) partOf a(HBP:"microtubule-binding region")
pmid:26192747 p(HGNC:MAPT, pmod(Ac, Lys, 385)) isA p(HGNC:MAPT, pmod(Ac))
pmid:24686445 a(HBP:"peripheral nervous system injury") increases p(HGNC:NGF)
pmid:24686445 p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAP43)
pmid:24686445 p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAL)
pmid:24686445 p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:BDNF)
pmid:23487739 a(HBP:Tubacin) directlyDecreases act(p(HGNC:HDAC6))
pmid:21427723 a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC))
pmid:21427723 a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(Ac))
pmid:20869593 a(HBP:C646) directlyDecreases act(p(HGNC:EP300))
pmid:20869593 a(HBP:C646) decreases p(HGNC:MAPT, pmod(Ac))
pmid:29540553 a(HBP:"Pathological Tau Spreading") negativeCorrelation act(p(HGNC:SIRT1))
pmid:29226865 p(HGNC:SRSF2, pmod(Ac, Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2))
pmid:28771976 a(HBP:RGFP966) directlyDecreases act(p(HGNC:HDAC3))
pmid:28771976 a(HBP:RGFP966) association bp(GO:memory)
pmid:29844403 a(HBP:MPT0G211) directlyDecreases act(p(HGNC:HDAC6))
pmid:29844403 a(HBP:MPT0G211) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9))
pmid:29844403 a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396))
pmid:29844403 a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404))
pmid:29844403 a(HBP:MPT0G211) increases bp(GO:learning)
pmid:29844403 a(HBP:MPT0G211) increases bp(GO:memory)
pmid:19732809 a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Alzheimer Disease")
pmid:19732809 a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Diabetes Mellitus, Type 2")
pmid:19732809 a(HBP:"O-GlcNAcylation") association bp(MESH:"Hot Temperature")
pmid:19732809 a(HBP:"O-GlcNAcylation") negativeCorrelation act(complex(GO:"proteasome complex"))
pmid:19732809 g(HGNC:OGT) positiveCorrelation act(complex(GO:"proteasome complex"))
pmid:26041011 a(HBP:"USP14 Aptamer") decreases act(p(HGNC:USP14))
pmid:27325702 p(HBP:"APP, ACR") association p(HGNC:STUB1)
pmid:27325702 p(HBP:"APP, ACR") association p(HBP:"CRL4 complex")
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SCAMP1, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SV2A, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SV2B, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:VAMP2, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SLC17A7, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SYT1, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SYT2, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:RAB14, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SNAP25, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SYN2, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:SYN1, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:RAB3A, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:APOE, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") increases p(HGNC:MAPT, pmod(Ub))
pmid:27325702 p(HBP:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex")
pmid:27325702 p(HBP:"CRL4 complex") association p(HBP:"APP, ACR")
pmid:27325702 p(HBP:"CRL4 complex") equivalentTo complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1))
pmid:27325702 p(HBP:"CRL4 complex") isA complex(GO:"ubiquitin ligase complex")
pmid:27325702 complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) equivalentTo p(HBP:"CRL4 complex")
pmid:25378699 p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:25378699 p(HGNC:MAPT, pmod(Sumo, Lys, 340)) decreases p(HGNC:MAPT, pmod(Ub))
pmid:16464864 p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
pmid:24905733 p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(Ub))
pmid:8391280 p(HGNC:MAPT, pmod(Ub, Lys, 257)) positiveCorrelation a(HBP:"paired helical filaments")
pmid:8391280 p(HGNC:MAPT, pmod(Ub, Lys, 311)) positiveCorrelation a(HBP:"paired helical filaments")
pmid:27260838 p(HBP:"Tau antibody, TNT1") association p(HBP:"phosphatase-activating domain")
pmid:27260838 p(HBP:"Tau antibody, TNT2") association p(HBP:"phosphatase-activating domain")
pmid:27260838 p(HBP:pretangles) positiveCorrelation p(HBP:"phosphatase-activating domain")
pmid:27601475 a(HBP:"8-nitro-cGMP") decreases a(HBP:"Tau oligomers")
pmid:27601475 a(HBP:"8-nitro-cGMP") positiveCorrelation a(CHEBI:"nitric oxide")
pmid:27601475 act(p(ECCODE:"1.14.13.39")) directlyIncreases a(CHEBI:"nitric oxide")
pmid:27373205 p(HBP:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
pmid:11606569 g(DBSNP:rs63750688) equivalentTo p(HGNC:MAPT, var("p.Lys280del"))
pmid:27716675 a(HBP:neuroinflammation) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
pmid:27716675 a(HBP:neuroinflammation) positiveCorrelation g(DBSNP:rs63751438)
pmid:27716675 a(HBP:neuroinflammation) positiveCorrelation a(HBP:"Tau oligomers")
pmid:27716675 g(DBSNP:rs63751438) positiveCorrelation a(HBP:neuroinflammation)
pmid:19765634 g(DBSNP:rs761059) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:19765634 g(DBSNP:rs8052688) positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:19765634 g(DBSNP:rs8063) positiveCorrelation path(MESH:"Cognitive Dysfunction")
pmid:21843595 p(MGI:Sumo3) negativeCorrelation bp(GO:learning)
pmid:21843595 p(MGI:Sumo3) negativeCorrelation bp(GO:memory)
pmid:19782030 act(p(RGD:Stat1)) increases r(RGD:Irf1)
pmid:19782030 act(p(RGD:Stat1)) increases r(RGD:Tnf)
pmid:19782030 act(p(RGD:Stat1)) increases r(RGD:Il6)
pmid:19782030 p(RGD:Pias1) increases p(RGD:Nr1h2, pmod(Sumo))
pmid:19782030 p(RGD:Nr1h2, pmod(Sumo)) increases act(p(RGD:Stat1))
pmid:19782030 p(RGD:Hdac4) increases p(RGD:Nr1h3, pmod(Sumo))
pmid:19782030 p(RGD:Nr1h3, pmod(Sumo)) increases act(p(RGD:Stat1))
pmid:19323834 complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2)
pmid:19323834 p(FPLX:CEBP) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1))
pmid:19323834 p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2)
pmid:18675254 p(HGNC:UBE2I) partOf complex(GO:"endoplasmic reticulum")
pmid:19323834 p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2)
pmid:18675254 p(HGNC:APP, pmod(Sumo, Lys, 587)) decreases a(CHEBI:"amyloid-beta")
pmid:18675254 p(HGNC:APP, pmod(Sumo, Lys, 595)) decreases a(CHEBI:"amyloid-beta")
pmid:18675254 p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 587))
pmid:18675254 p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 595))
pmid:17346237 p(HGNC:SUMO3) increases p(HGNC:BACE1)
pmid:17346237 p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_711"))
pmid:17346237 p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_713"))
pmid:16464864 a(CHEBI:colchicine) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340))
pmid:12506199 p(HGNC:APP, pmod(Sumo)) increases a(CHEBI:"amyloid-beta")
pmid:12506199 p(HGNC:APP, pmod(HBP:polysumoylation)) decreases a(CHEBI:"amyloid-beta")
pmid:29334120 p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403))
pmid:29334120 p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404))
pmid:29334120 p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409))
pmid:29334120 p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410))
pmid:29334120 p(HGNC:TARDBP, pmod(Ph, Ser, 409)) increases act(p(HGNC:TARDBP))
pmid:29334120 p(HGNC:TARDBP, pmod(Ph, Ser, 410)) increases act(p(HGNC:TARDBP))
pmid:26142647 p(HGNC:PPP1R15A) regulates act(p(HGNC:PPP1CA))
pmid:29421605 p(RGD:Ptpn1) negativeCorrelation p(RGD:Irs1, pmod(Ph))
pmid:29421605 p(RGD:Ptpn1) negativeCorrelation p(RGD:Akt1, pmod(Ph))
pmid:29421605 p(RGD:Ptpn1) negativeCorrelation p(RGD:Gsk3b, pmod(Ph))
pmid:29421605 p(RGD:Ptpn1) negativeCorrelation p(RGD:Mtor, pmod(Ph))
pmid:29421605 p(RGD:Ptpn1) negativeCorrelation p(RGD:Ntrk2, pmod(Ph))
pmid:29421605 p(RGD:Irs1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1)
pmid:29421605 p(RGD:Akt1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1)
pmid:29421605 p(RGD:Gsk3b, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1)
pmid:29421605 p(RGD:Mtor, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1)
pmid:29421605 p(RGD:Ntrk2, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1)
pmid:29062069 p(HGNC:MID1) decreases act(p(HGNC:PPP2CA))
pmid:28422052 a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(Ph, Ser, 396))
pmid:28422052 a(CHEBI:"folic acid") increases p(MGI:Dnmt1)
pmid:28422052 p(MGI:Dnmt1) increases p(MGI:Ppp2ca, pmod(Me, Leu, 309))
pmid:28422052 p(MGI:Ppp2ca, pmod(Me, Leu, 309)) decreases act(p(MGI:Ppp2ca))
pmid:25143394 p(MGI:Ppp1ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation))
pmid:25143394 p(MGI:Ppp1cb) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation))
pmid:23134599 a(CHEBI:"lead diacetate") decreases p(RGD:Ppp2ca)
pmid:23134599 a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca)
pmid:23134599 a(CHEBI:"lead diacetate") increases p(RGD:Ppp5c)
pmid:23134599 p(RGD:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation))
pmid:21489990 act(p(RGD:Ppp1ca)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 262))
pmid:21489990 p(RGD:Egr1) directlyIncreases act(p(RGD:Cdk5))
pmid:19623258 act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT8")
pmid:19623258 act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT180")
pmid:19623258 p(HBP:"Tau epitope, AT180") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex"))
pmid:19623258 p(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231))
pmid:25001178 act(p(HGNC:DUSP6)) negativeCorrelation act(p(HGNC:MAPK1), ma(kin))
pmid:24964035 p(HGNC:SMAD2) decreases p(HGNC:PIN1)
pmid:24964035 p(HGNC:SMAD3) decreases p(HGNC:PIN1)
pmid:23832849 act(p(INTERPRO:"FKBP-type peptidyl-prolyl cis-trans isomerase domain")) directlyDecreases p(HBP:"tubulin-binding repeat 3")
pmid:22926167 p(HGNC:PIN1, pmod(Ph, Ser, 16)) negativeCorrelation p(HGNC:MAPT)
pmid:22926167 p(HGNC:PIN1, pmod(Ph, Ser, 16)) decreases act(p(HGNC:PIN1))
pmid:22926167 p(HGNC:PIN1, pmod(Ph, Ser, 65)) negativeCorrelation p(HGNC:MAPT)
pmid:22926167 p(HGNC:PIN1, pmod(Ph, Ser, 65)) increases act(p(HGNC:PIN1))
pmid:22926167 p(HGNC:PIN1, pmod(Ac, Lys, 46)) negativeCorrelation p(HGNC:MAPT)
pmid:19401603 complex(GO:"tubulin complex") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
pmid:28019679 bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:28019679 act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18)
pmid:28019679 act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B)
pmid:28019679 act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B)
pmid:24561250 complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B)
pmid:24561250 complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B)
pmid:28019679 complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1))
pmid:28019679 act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1)
pmid:27314526 complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1)
pmid:28019679 complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide")
pmid:28019679 complex(GO:"NLRP3 inflammasome complex") increases sec(p(HGNC:TNF))
pmid:28019679 act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory")
pmid:28019679 act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:"amyloid-beta")
pmid:24561250 complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease")
pmid:24561250 complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid")
pmid:28019679 a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:28019679 composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:28019679 composite(a(CHEBI:"amyloid-beta"), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:28019679 complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1))
pmid:23702978 complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1))
pmid:28019679 act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6))
pmid:28019679 act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42")
pmid:28019679 complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis)
pmid:28019679 complex(GO:"NLRP1 inflammasome complex") increases bp(HBP:HBP00027)
pmid:23702978 complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5))
pmid:24561250 complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B)
pmid:24561250 act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B)
pmid:24561250 act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B))
pmid:24561250 act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18))
pmid:23702978 complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B))
pmid:24561250 complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B)
pmid:24561250 complex(GO:"inflammasome complex") increases p(HGNC:IL1B)
pmid:24561250 complex(GO:"inflammasome complex") regulates p(HGNC:IL1B)
pmid:27314526 complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B))
pmid:23702978 complex(GO:"inflammasome complex") increases act(p(HGNC:IL18))
pmid:24561250 complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18)
pmid:24561250 complex(GO:"inflammasome complex") increases p(HGNC:IL18)
pmid:24561250 act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18)
pmid:24561250 complex(GO:"inflammasome complex") regulates p(HGNC:IL18)
pmid:27314526 complex(GO:"inflammasome complex") increases act(p(HGNC:IL18))
pmid:23702978 complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1))
pmid:23702978 complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1))
pmid:24561250 act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1))
pmid:27314526 act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1))
pmid:27314526 complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1))
pmid:23702978 act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis)
pmid:23702978 complex(GO:"inflammasome complex") increases bp(GO:pyroptosis)
pmid:27314526 complex(GO:"inflammasome complex") increases bp(GO:pyroptosis)
pmid:23702978 complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11))
pmid:27314526 complex(GO:"inflammasome complex") increases act(p(HGNC:IL33))
pmid:27314526 complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease")
pmid:23702978 p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1))
pmid:24561250 p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex"))
pmid:24561250 p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex"))
pmid:24561250 p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex"))
pmid:24561250 p(HGNC:PYCARD) increases p(HGNC:IL18)
pmid:24561250 p(HGNC:PYCARD) increases p(HGNC:IL1B)
pmid:24561250 p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23702978 path(MESH:"Immune System Diseases") increases path(MESH:Atherosclerosis)
pmid:23702978 path(MESH:"Immune System Diseases") increases path(MESH:"Diabetes Mellitus, Type 2")
pmid:23702978 path(MESH:"Immune System Diseases") increases path(MESH:"Neurodegenerative Diseases")
pmid:23702978 complex(p(HGNC:CASP1), p(HGNC:CASP1)) increases act(p(HGNC:CASP1))
pmid:23702978 bp(GO:"cell activation") increases p(HGNC:IL18)
pmid:24561250 p(HGNC:NLRP1) increases p(HGNC:IL18)
pmid:24561250 p(HGNC:NLRP1) increases p(HGNC:IL1B)
pmid:27314526 p(HGNC:NLRP3) association a(CHEBI:"amyloid-beta")
pmid:27314526 act(p(HGNC:NLRP3)) increases sec(p(HGNC:CASP1))
pmid:23702978 p(HGNC:NLRP6) increases bp(GO:"negative regulation of innate immune response")
pmid:23702978 p(HGNC:NLRP12) increases bp(GO:"dendritic cell migration")
pmid:23702978 p(HGNC:NLRP12) increases bp(GO:"negative regulation of NIK/NF-kappaB signaling")
pmid:23702978 act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11))
pmid:24561250 p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:23702978 complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1))
pmid:24561250 complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B)
pmid:24561250 complex(GO:"IPAF inflammasome complex") increases sec(p(HGNC:IL1B))
pmid:24561250 act(complex(GO:"IPAF inflammasome complex")) increases sec(p(HGNC:IL1B))
pmid:24561250 complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B)
pmid:24561250 complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease")
pmid:23702978 composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1))
pmid:23702978 composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1))
pmid:23702978 act(p(HGNC:IFI16)) increases act(p(HGNC:TMEM173))
pmid:23702978 act(p(HGNC:DDX58)) increases act(p(HGNC:MAVS))
pmid:23702978 a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58))
pmid:27314526 a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:23702978 act(p(HGNC:MAVS)) increases bp(GO:"response to type I interferon")
pmid:23702978 a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16))
pmid:23702978 act(p(HGNC:TMEM173)) increases bp(GO:"response to type I interferon")
pmid:23702978 a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1))
pmid:23702978 complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex"))
pmid:23702978 complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex"))
pmid:23702978 act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex")
pmid:24561250 p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex"))
pmid:23702978 p(HGNC:SCAF11) increases bp(GO:pyroptosis)
pmid:23702978 act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis)
pmid:23702978 a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway")
pmid:23702978 bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates sec(a(MESH:"Interferon Type I"))
pmid:23702978 bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11)
pmid:23702978 bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1))
pmid:23702978 bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8))
pmid:23702978 a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL1B))
pmid:23702978 a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL18))
pmid:23702978 act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11))
pmid:23702978 p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11))
pmid:23702978 p(HGNC:PRTN3) increases act(p(HGNC:IL1B))
pmid:23702978 p(HGNC:CASP8) increases act(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18))
pmid:23702978 act(p(HGNC:CLEC7A)) increases act(p(HGNC:SYK))
pmid:23702978 complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD))
pmid:23702978 complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) increases act(p(HGNC:IL1B))
pmid:23702978 complex(GO:ripoptosome) increases act(p(HGNC:CASP8))
pmid:23702978 complex(GO:ripoptosome) increases act(p(HGNC:RIPK3))
pmid:23702978 p(HGNC:XIAP) decreases complex(GO:ripoptosome)
pmid:23702978 p(HGNC:BIRC3) decreases complex(GO:ripoptosome)
pmid:23702978 act(p(HGNC:RIPK3)) increases act(p(HGNC:IL1B))
pmid:23702978 act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP1))
pmid:23702978 act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8))
pmid:23702978 p(FPLX:TNFRSF) increases p(HGNC:NLRP3)
pmid:23702978 p(HGNC:BRCC3) decreases p(HGNC:NLRP3, pmod(Ub))
pmid:23702978 p(FPLX:IFNB) increases p(HGNC:AIM2)
pmid:23702978 g(HGNC:NLRP3, var("?")) positiveCorrelation path(MESH:"Cryopyrin-Associated Periodic Syndromes")
pmid:24561250 g(HGNC:NLRP3) increases a(CHEBI:"amyloid-beta")
pmid:24561250 g(HGNC:NLRP3) decreases bp(GO:memory)
pmid:24561250 g(HGNC:NLRP3) decreases bp(GO:behavior)
pmid:23702978 path(MESH:"Cryopyrin-Associated Periodic Syndromes") positiveCorrelation g(HGNC:NLRP3, var("?"))
pmid:23702978 bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:23702978 bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:23702978 p(HGNC:NLRP3, pmod(NO)) decreases act(p(HGNC:NLRP3))
pmid:23702978 a(MESH:Interferons) increases p(HGNC:AIM2)
pmid:23702978 a(MESH:Interferons) decreases p(HGNC:IL1B)
pmid:23702978 a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:23702978 m(HGNC:MIR223) decreases p(HGNC:NLRP3)
pmid:23702978 act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9))
pmid:23702978 p(HGNC:MAP3K7) association a(CHEBI:"calcium(2+)")
pmid:23702978 p(HGNC:TRPM2) increases act(p(HGNC:NLRP3))
pmid:23702978 act(p(HGNC:TRPM2)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space"))
pmid:23702978 p(HGNC:CASP9, pmod(NO)) decreases act(p(HGNC:CASP9))
pmid:23702978 p(HGNC:CASP1, pmod(NO)) decreases act(p(HGNC:CASP1))
pmid:23702978 complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9))
pmid:23702978 complex(p(HGNC:CASP1), p(MGI:Casp12)) decreases act(p(HGNC:CASP1))
pmid:23702978 p(HGNC:CARD18) decreases act(p(HGNC:CASP1))
pmid:23702978 p(HGNC:CARD16) decreases act(p(HGNC:CASP1))
pmid:23702978 p(HGNC:CARD17) decreases p(HGNC:IL1B)
pmid:23702978 p(HGNC:PYDC1) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD))
pmid:23702978 p(HGNC:PYDC2) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD))
pmid:23702978 p(MGI:Mefv) decreases sec(p(MGI:Il1b))
pmid:23702978 composite(p(FPLX:HSP90), p(HGNC:SUGT1)) increases act(p(HGNC:NLRP3))
pmid:24561250 path(MESH:Stroke) increases complex(GO:"inflammasome complex")
pmid:24561250 composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:NLRP2)
pmid:24561250 composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD)
pmid:24561250 composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD)
pmid:24561250 composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B)
pmid:24561250 composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B)
pmid:24561250 composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:CASP1)
pmid:24561250 composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL18)
pmid:24561250 p(HGNC:NLRP2) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 p(INTERPRO:"Leucine-rich repeat-containing adjacent domain") partOf a(MESH:"NLR Proteins")
pmid:24561250 p(INTERPRO:"NACHT-associated domain") partOf a(MESH:"NLR Proteins")
pmid:24561250 p(INTERPRO:"DAPIN domain") partOf p(INTERPRO:"NACHT-associated domain")
pmid:24561250 p(INTERPRO:"CARD domain") partOf p(INTERPRO:"NACHT-associated domain")
pmid:24561250 p(INTERPRO:"BIR repeat") partOf p(INTERPRO:"NACHT-associated domain")
pmid:24561250 a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex")
pmid:24561250 a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex"))
pmid:24561250 a(MESH:Alarmins) increases complex(GO:"inflammasome complex")
pmid:24561250 a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex"))
pmid:24561250 complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex")
pmid:24561250 complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:24561250 complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:24561250 a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex"))
pmid:24561250 a(MESH:Viruses) increases act(complex(GO:"inflammasome complex"))
pmid:24561250 a(MESH:Fungi) increases act(complex(GO:"inflammasome complex"))
pmid:24561250 a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex"))
pmid:24561250 deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex"))
pmid:24561250 path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:24561250 path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:24561250 path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL18))
pmid:24561250 path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL1B))
pmid:24561250 path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP)
pmid:24561250 p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:24561250 p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:27314526 act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response")
pmid:27314526 act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process")
pmid:27314526 act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation")
pmid:27314526 p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex"))
pmid:27314526 p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease")
pmid:24561250 p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:24561250 p(MGI:P2rx4) increases p(HGNC:IL1B)
pmid:24561250 p(MGI:P2rx4) increases p(HGNC:IL1B)
pmid:24561250 p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex"))
pmid:24561250 p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:24561250 composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) increases p(HGNC:IL1B)
pmid:24561250 p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 p(HGNC:PANX1) increases p(HGNC:IL1B)
pmid:24561250 p(HGNC:PANX1) increases p(HGNC:IL18)
pmid:24561250 a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex")
pmid:24561250 a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex"))
pmid:24561250 p(MGI:Nlrp3) increases p(MGI:Il1b)
pmid:24561250 p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation")
pmid:24561250 p(MGI:Nlrp3) increases a(MESH:Neuropathology)
pmid:24561250 p(MGI:Nlrp3) decreases bp(GO:cognition)
pmid:24561250 composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) increases p(HGNC:IL1B)
pmid:24561250 composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) increases p(HGNC:IL1B)
pmid:24561250 a(CHEBI:"saturated fatty acid") increases p(HGNC:IL1B)
pmid:24561250 a(CHEBI:probenecid) decreases p(HGNC:PANX1)
pmid:24561250 a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 a(CHEBI:probenecid) decreases p(HGNC:IL1B)
pmid:24561250 a(CHEBI:probenecid) decreases p(HGNC:IL18)
pmid:24561250 a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex"))
pmid:24561250 a(CHEBI:probenecid) increases bp(GO:learning)
pmid:24561250 a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7))
pmid:24561250 a(PUBCHEM:6324599) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
pmid:24561250 p(MGI:Casp1) increases bp(GO:"amyloid-beta formation")
pmid:24561250 p(MGI:Casp1) increases a(MESH:Neuropathology)
pmid:24561250 p(MGI:Casp1) decreases bp(GO:cognition)
pmid:27314526 bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response")
pmid:27314526 act(p(HGNC:PRSS3)) increases p(HGNC:IL18)
pmid:27314526 act(p(FPLX:ELA)) increases p(HGNC:IL18)
pmid:27314526 act(p(HGNC:CTSG)) increases p(HGNC:IL18)
pmid:27314526 composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1))
pmid:27314526 path(MESH:Periodontitis) decreases bp(GO:cognition)

Curation Quality

Namespaces

Namespace References 18

This section lists all of the namespaces that are defined in the original BEL document.

Keyword URL
CHEBI https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns
DOID https://raw.githubusercontent.com/pharmacome/terminology/c0c576e3d3ab9b25a3982251a4ee2fd7c49e1679/external/doid-names.belns
DRUGBANK https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/drugbank-names.belns
ECCODE https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/ec-code.belns
FB https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/fb-names.belns
FPLX https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns
GO https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns
HBP https://raw.githubusercontent.com/pharmacome/terminology/3074b85b858455d8eeb76cfcdef685ced19bbe11/export/hbp-names.belns
HGNC https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns
HGNCGENEFAMILY https://raw.githubusercontent.com/pharmacome/terminology/3074b85b858455d8eeb76cfcdef685ced19bbe11/external/hgnc.genefamily-names.belns
HP https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns
INTERPRO https://arty.scai.fraunhofer.de/artifactory/bel/namespace/interpro/interpro-20170731.belns
MESH https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns
MGI https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns
MIRBASE https://raw.githubusercontent.com/pharmacome/terminology/0c9853baf883545b922ff1b138a9f297a70b7951/external/mirbase-names.belns
NCBIGENE https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/entrez.belns
PFAM https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/pfam-names.belns
RGD https://arty.scai.fraunhofer.de/artifactory/bel/namespace/rgd-rat-genes/rgd-rat-genes-20170725.belns

Unused Namespaces 2

The source BEL document contained references to the following namespaces, but they were never used. It is suggested to delete their definitions from the BEL document to improve readability and parsing speed.

  • DOID
  • FB

Namespaces with Incorrect Names 6

  • GO
  • HBP
  • HGNCGENEFAMILY
  • INTERPRO
  • MESH
  • MGI

Annotations

Annotation References 12

This section lists all of the annotations that are defined in the original BEL document.

Keyword URL
Anatomy https://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno
Cell https://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell/cell-20170511.belanno
CellLine https://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell-line/cell-line-20170511.belanno
CellStructure https://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell-structure/cell-structure-20170511.belanno
Confidence https://arty.scai.fraunhofer.de/artifactory/bel/annotation/confidence/confidence-1.0.0.belanno
Disease https://arty.scai.fraunhofer.de/artifactory/bel/annotation/disease/disease-20170511.belanno
Gender https://arty.scai.fraunhofer.de/artifactory/bel/annotation/gender/gender-1.0.0.belanno
MeSHAnatomy https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno
MeSHDisease https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno
Species https://arty.scai.fraunhofer.de/artifactory/bel/annotation/species-taxonomy-id/species-taxonomy-id-20170511.belanno
Subgraph https://arty.scai.fraunhofer.de/artifactory/bel/annotation/neurommsig/neurommsig-1.0.3.belanno
TextLocation https://arty.scai.fraunhofer.de/artifactory/bel/annotation/text-location/text-location-1.0.1.belanno

Locally Defined Annotations 34

The source BEL document contained annotations defined as a list. Click each link to export the list definition as a BELANNO file that can hosted externally to promote re-usability and interoperability. After, you can replace the list definition in the source BEL with a SET ANNOTATION X AS URL "Y" definition.

  • AssayType
  • Braak_Stage
  • Cell_Line
  • Disease_Progression
  • Duration
  • Enzyme_Acitvity
  • ExpMethod
  • GOCC
  • Half_life
  • HasQuantitativeInformation
  • HBP_Disease
  • IC50
  • Ki
  • Km
  • Km_ATP
  • MeasurementRelation
  • MeasurementType
  • MeasurementUnits
  • MeasurementValue
  • Method
  • MouseStrain
  • PublicationType
  • Research_Model
  • Study_Group
  • Substrate_Concentration
  • Tau_Antibody
  • Tau_Domain
  • Tau_Epitope
  • Tau_Motif
  • Tau_State
  • Tau_Structure
  • TauIsoform
  • TauIsoformGradient
  • Vmax

Unused Locally Defined Annotations 9

The source BEL document contained the following list annotations, but no references to the following values. It is suggested to prune these values from the list definitions.

Note: this may be due to errors occurring in all statements with these annotations.

Annotation Values
HasQuantitativeInformation
  • False
Km_ATP
  • 10 μM
MeasurementType
  • CSF concentration
  • plasma concentration
  • brain concertration
MeasurementValue
  • 1.4
  • 1.3
Method
  • Microtubule polymerization Assay
PublicationType
  • Research
  • Comment
Research_Model
  • K3 model with hyperphoshorylated tau resembling FTD
Tau_Epitope
  • AT270
  • AD2
  • AP422
Vmax
  • 656 nM/min/mg
  • 59 μM

Warnings

Warning Statistics

Most Frequent 20 Errors

Error Frequency
"pro-nerve growth factor, human" is not in the MESH namespace 7
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace 6
"latrepirdine" is not in the MESH namespace 5
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace 5
"Nitrosative Stress" is not in the MESH namespace 4
"neuroinflammatory response" is not in the GO namespace 4
"gambogic amide" is not in the MESH namespace 3
"Synaptotagmins" is not in the HGNCGENEFAMILY namespace 3
"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace 2
"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace 2
"Tau antibody, CP13" is not in the HBP namespace 2
"soluble tau" is not in the HBP namespace 2
"3-3' dityrosine cross-linking" is not in the HBP namespace 2
"CA1 interneuron" is not in the HBP namespace 2

All Errors 58

Path Line BEL Message
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 365 path(MESH:D060825) -> a(MESH:"pro-nerve growth factor, human") "pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 366 path(MESH:D000544) -> a(MESH:"pro-nerve growth factor, human") "pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 368 complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) -> bp(GO:"GO:0031175") "pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 385 a(MESH:"pro-nerve growth factor, human") pos path(MESH:D003072) "pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 398 a(MESH:"pro-nerve growth factor, human") biomarkerFor path(MESH:D000544) "pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 414 complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NGFR)) -> bp(GO:"GO:0006915") "pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 450 composite(complex(p(HGNC:NGFR), p(HGNC:SORT1)), a(MESH:"pro-nerve growth factor, human")) -> bp(GO:"GO:0006915") "pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 523 p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(Ph)) -> act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) "Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 544 act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) -- bp(GO:"GO:0031175") "Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 603 complex(a(MESH:"gambogic amide"), p(HGNC:NTRK1)) => p(HGNC:NTRK1, pmod(Ph)) "gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 609 a(MESH:"gambogic amide") -| bp(HBP:Excitotoxicity) "gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 610 a(MESH:"gambogic amide") -> bp(GO:"GO:0031175") "gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 624 p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") hasMembers list(p(HGNC:CHRNA1) , p(HGNC:CHRNA2), p(HGNC:CHRNA3), p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNA6), p(HGNC:CHRNA7), p(HGNC:CHRNA9), p(HGNC:CHRNA10), p(HGNC:CHRNB1), p(HGNC:CHRNB2), p(HGNC:CHRNB3), p(HGNC:CHRNB4), p(HGNC:CHRND), p(HGNC:CHRNG)) "Cholinergic receptors nicotinic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 629 p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") hasMembers list(p(HGNC:CHRM1), p(HGNC:CHRM2), p(HGNC:CHRM3), p(HGNC:CHRM4), p(HGNC:CHRM5)) "Cholinergic receptors muscarinic" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 732 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| path(MESH:D060825) "(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 733 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| path(MESH:D024801) "(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 734 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| a(CHEBI:"amyloid-beta polypeptide 42") "(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 735 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -> act(p(MGI:Chrm1)) "(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 737 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| p(MGI:Bace1) "(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 738 a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| act(p(MGI:Gsk3b)) "(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 758 path(MESH:D000544) -| r(HGNCGENEFAMILY:"Synaptotagmins") "Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 762 p(HGNCGENEFAMILY:"Synaptotagmins") -- bp(GO:"GO:0031629") "Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 764 p(HGNCGENEFAMILY:"Synaptotagmins") -- bp(GO:"GO:0007269") "Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 782 p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits") -> p(HGNC:MAPT, pmod(Ph)) "Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 783 act(p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits")) -| bp(HBP:hyperphosphorylation) "Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 1007 a(MESH:"latrepirdine") -| act(p(HGNC:BCHE)) "latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 1008 a(MESH:"latrepirdine") -| act(p(HGNC:ACHE)) "latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 1010 a(MESH:"latrepirdine") -| bp(GO:"GO:0098989") "latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 1012 a(MESH:"latrepirdine") -| bp(GO:"GO:0046902") "latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel 1013 a(MESH:"latrepirdine") -> bp(MESH:D000066829) "latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 139 complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, PHF1"))) "Tau antibody, PHF1" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 140 complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, CP13"))) "Tau antibody, CP13" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 142 p(MGI:Tfeb) cnc p(MGI:Cp13) "Cp13" is not in the MGI namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 145 complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, AT8"))) "Tau antibody, AT8" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 146 complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, AT180"))) "Tau antibody, AT180" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 147 complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, CP13"))) "Tau antibody, CP13" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 151 p(MGI:Tfeb) -| p(HBP:"soluble tau",pmod(Ph)) "soluble tau" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 152 p(MGI:Tfeb) cnc p(HBP:"soluble tau") "soluble tau" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel 164 complex(p(HBP:"Tau antibody,MC1")) "Tau antibody,MC1" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel 106 p(HBP:"tubulin-binding repeat 1") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") "Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel 107 p(HBP:"tubulin-binding repeat 2") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") "Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel 108 p(HBP:"tubulin-binding repeat 3") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") "Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel 109 p(HBP:"tubulin-binding repeat 4") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") "Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel 129 p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat", pmod(Ph)) -| complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) "Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 610 a(CHEBI:"amyloid-beta") -> bp(MESH:"Nitrosative Stress") "Nitrosative Stress" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 611 bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) "Nitrosative Stress" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 612 bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) "Nitrosative Stress" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 852 a(CHEBI:peroxynitrite) -> bp(MESH:"Nitrosative Stress") "Nitrosative Stress" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 920 a(CHEBI:peroxynitrite) -> a(HBP:"3-3' dityrosine cross-linking") "3-3' dityrosine cross-linking" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 921 a(HBP:"3-3' dityrosine cross-linking") pos a(HBP:"paired helical filaments") "3-3' dityrosine cross-linking" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 1488 p(MGI:Ttbk1) -> bp(GO:"neuroinflammatory response") "neuroinflammatory response" is not in the GO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 1862 act(p(MGI:Dapk1)) neg tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron")) "CA1 interneuron" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 1863 tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron")) pos bp(GO:memory) "CA1 interneuron" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 2478 act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) pos a(HBP:"long-term depression") "long-term depression" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 2946 a(CHEBI:lipopolysaccharide) -> bp(GO:"neuroinflammatory response") "neuroinflammatory response" is not in the GO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 2947 a(CHEBI:"amyloid-beta") -> bp(GO:"neuroinflammatory response") "neuroinflammatory response" is not in the GO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 2948 a(HBP:"C-30-27") -| bp(GO:"neuroinflammatory response") "neuroinflammatory response" is not in the GO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel 3396 a(HBP:MPT0G211) -> p(HBP:"Blood-Brain Barrier") "Blood-Brain Barrier" is not in the HBP namespace

Biogrammar

Regulatory Pairs 27

These pairs of nodes represent motifs like A increases B and B decreases A.

Node A Node B
p(HGNC:PIN1) p(HGNC:SMAD2)
a(MESH:Neurons) p(HGNC:MAPT)
p(HGNC:MAPT) bp(HP:Neurodegeneration)
a(GO:synapse) p(HGNC:MAPT)
p(HGNC:TNF) a(CHEBI:nicotine)
p(HGNC:RELA) bp(GO:"long-term synaptic potentiation")
bp(GO:"late endosomal microautophagy") p(MGI:Mapt)
p(HGNC:CHRNA7) a(CHEBI:"amyloid-beta")
complex(GO:"proteasome complex") a(CHEBI:"amyloid-beta")
bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") p(HGNC:MAPT)
bp(GO:"calcium ion homeostasis") complex(GO:"NF-kappaB complex")
complex(GO:"NF-kappaB complex") a(CHEBI:"amyloid-beta")
p(HGNC:CHRNA7) a(CHEBI:anandamide)
a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7)
p(HGNC:NFKB1) bp(GO:"long-term synaptic potentiation")
a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:AK1)
bp(GO:autophagy) p(HGNC:MAPT)
a(CHEBI:"amyloid-beta") a(MESH:Microglia)
p(HGNC:CHRNA7) complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))
path(MESH:Tauopathies) p(MGI:Tfeb)
complex(GO:"protein phosphatase type 2A complex") p(HGNC:GSK3B)
a(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease")
bp(GO:autophagy) p(HGNC:SNCA)
bp(GO:autophagy) p(HGNC:HTT, var("?"))
bp(GO:"membrane depolarization") complex(GO:"NF-kappaB complex")
p(MGI:Mapt, var("p.Pro301Leu")) bp(GO:macroautophagy)
a(CHEBI:"amyloid-beta") p(HGNC:APOE)

Contradictory Pairs 158

These pairs of nodes have a contradiction in their causal relationships, meaning they have more than one of INCREASES, DECREASES, or CAUSES NO CHANGE. This may be due to different experimental conditions, so these statements need to be carefully considered in analyses.

Source Relations Target
a(CHEBI:"Evans blue") increases, causesNoChange a(PUBCHEM:9832404)
p(MGI:Chrna7) increases, decreases a(CHEBI:"amyloid-beta")
composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases, decreases path(MESH:Smell)
p(HGNC:MAPT) causesNoChange, increases, association, regulates bp(GO:"axonal transport")
a(CHEBI:"amyloid-beta") increases, decreases bp(GO:memory)
complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases, decreases bp(GO:"protein catabolic process")
a(PUBCHEM:675434) increases, causesNoChange p(FPLX:Proteasome)
complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) increases, hasComponent, decreases p(HGNC:BACE1)
p(HGNC:ACE) increases, decreases a(CHEBI:"amyloid-beta")
p(HGNC:TTBK2, var("p.Tyr448*")) increases, decreases p(HGNC:TTBK2)
a(MESH:Nicotine) increases, decreases p(MESH:"Receptors, GABA")
p(MGI:Chrna7) increases, decreases path(MESH:"Spatial Memory")
bp(MESH:Aging) increases, decreases p(FPLX:HSP90)
bp(GO:"response to endoplasmic reticulum stress") increases, decreases bp(GO:"cell death")
path(MESH:"Alzheimer Disease") decreases, positiveCorrelation, negativeCorrelation, increases, association p(HGNC:CHRNA7)
a(CHEBI:Thrombin) increases, causesNoChange p(HGNC:MAPT, frag("561_685"))
a(MESH:"SNARE Proteins") increases, causesNoChange p(HGNC:CHRNA7)
a(CHEBI:"dimethyl fumarate") increases, causesNoChange p(HGNC:NFE2L2)
p(HGNC:WNT3A) increases, decreases a(CHEBI:"amyloid-beta")
p(HGNC:ABCB1) increases, decreases a(CHEBI:"amyloid-beta")
a(MESH:antalarmin) increases, causesNoChange a(MESH:"Embryonic Structures")
bp(GO:autophagy) increases, decreases p(HGNC:APP)
a(PUBCHEM:9832404) increases, decreases r(HGNC:SLC17A7)
a(CHEBI:rosiglitazone) decreases, causesNoChange a(HBP:HBP00018)
p(HGNC:PICALM) increases, decreases, positiveCorrelation a(CHEBI:"amyloid-beta")
a(MESH:Liver) increases, decreases a(CHEBI:"amyloid-beta")
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases, decreases p(HGNC:TFAP2B)
bp(GO:autophagy) increases, decreases, association p(HGNC:MAPT)
bp(MESH:"Heat-Shock Response") increases, causesNoChange p(NCBIGENE:492507)
a(CHEBI:rivastigmine) increases, decreases p(HGNC:ACHE)
a(CHEBI:Anatabine) decreases, causesNoChange p(MGI:Ifng)
bp(MESH:Autophagy) increases, decreases p(HBP:"Tau C3")
p(HGNC:CDC37) increases, decreases p(HGNC:MAPT)
p(HGNC:CHRM1) increases, causesNoChange bp(GO:"ERK1 and ERK2 cascade")
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases, causesNoChange path(MESH:Smell)
p(HGNC:CHRNA7) increases, decreases, regulates a(CHEBI:"glutamate(2-)")
p(HGNC:BCHE) decreases, directlyIncreases a(CHEBI:acetylcholine)
complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) increases, decreases bp(GO:"anterograde axonal protein transport")
a(MESH:Neurons) increases, causesNoChange p(HGNC:MAPT)
p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) increases, decreases complex(GO:"protein phosphatase type 2A complex")
p(HGNC:TTBK2, var("p.Asp449*")) increases, decreases p(HGNC:TTBK2)
a(CHEBI:galanthamine) increases, decreases p(HGNC:ACHE)
a(MESH:Kidney) increases, decreases a(CHEBI:"amyloid-beta")
p(HGNC:IDE) increases, decreases a(CHEBI:"amyloid-beta")
a(CHEBI:"amyloid-beta polypeptide 42") decreases, causesNoChange p(ECCODE:"2.7.11.31")
a(CHEBI:Anatabine) decreases, causesNoChange p(MGI:Tnf)
a(CHEBI:"amyloid-beta") decreases, causesNoChange path(HBP:Neurodegeneration)
a(CHEBI:nicotine) decreases, causesNoChange a(CHEBI:"amyloid-beta")
a(CHEBI:chloroquine) increases, decreases p(HGNC:MAPT)
a(CHEBI:"chondroitin sulfate") decreases, causesNoChange a(HBP:"Tau isoform F (441 aa)")
a(CHEBI:rolipram) increases, decreases p(HGNC:MAPT)
p(HGNC:MAPT) negativeCorrelation, decreases, causesNoChange a(GO:synapse)
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases, causesNoChange p(HGNC:SLC17A7)
bp(MESH:Autophagy) increases, causesNoChange p(HGNC:MAPT)
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases, causesNoChange bp(MESH:"Hand Strength")
bp(GO:autophagy) increases, decreases path(HBP:neurotoxicity)
a(CHEBI:nicotine) increases, decreases p(HBP:"alpha-4 beta-2 nAChR")
p(FPLX:mTORC1) increases, decreases p(HGNC:TFEB)
p(HGNC:BACE1, frag("228_236")) increases, decreases a(HBP:"sAPP-alpha")
a(HBP:"amyloid-beta oligomers") increases, decreases p(HGNC:DLG4)
a(CHEBI:Anatabine) decreases, causesNoChange bp(HBP:Astrogliosis)
p(HGNC:CHRNA7) decreases, positiveCorrelation, increases, association, regulates a(CHEBI:"amyloid-beta")
path(MESH:"Alzheimer Disease") causesNoChange, increases, association, positiveCorrelation p(HGNC:MAPT)
p(HGNC:MAPT) increases, causesNoChange bp(GO:"anterograde axonal protein transport")
p(HGNC:RAB5A) increases, decreases bp(GO:endocytosis)
a(CHEBI:"amyloid-beta") increases, decreases a(CHEBI:acetylcholine)
p(HGNC:TFEB) increases, decreases, regulates a(CHEBI:"amyloid-beta")
p(HGNC:MAPT) increases, decreases, regulates a(MESH:Neurons)
p(HGNC:CHAT) increases, decreases, directlyIncreases a(CHEBI:acetylcholine)
p(MGI:Mapt, var("p.Ala152Thr")) increases, decreases p(MGI:Mapt)
a(CHEBI:ambroxol) increases, decreases p(HGNC:SNCA)
a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases, decreases bp(HP:Neurodegeneration)
p(MGI:Vegfc) increases, causesNoChange a(MESH:"Lymphatic Vessels")
a(CHEBI:nifedipine) increases, causesNoChange bp(GO:"calcium-mediated signaling")
a(CHEBI:"amyloid-beta") increases, decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
a(MESH:Nicotine) increases, decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
p(HGNC:TTBK2, var("p.Glu450*")) increases, decreases p(HGNC:TTBK2)
p(HGNC:PRKN, var("?")) increases, decreases p(HGNC:PRKN)
p(HGNC:OTUB1) increases, decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
bp(MESH:"Oxidative Stress") increases, causesNoChange bp(GO:"apoptotic process")
p(HGNC:HSPB1) increases, decreases, causesNoChange p(HGNC:MAPT)
p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) increases, decreases complex(GO:"protein phosphatase type 2A complex")
p(HGNC:OTUB1) increases, decreases, regulates p(HGNC:MAPT)
p(MGI:Chrna7) increases, decreases p(MGI:Map2)
a(CHEBI:"Hsp90 inhibitor") increases, decreases p(HGNC:MAPT)
a(MESH:Nicotine) increases, decreases p(HGNC:CHRNA7)
a(CHEBI:nicotine) increases, decreases, regulates a(CHEBI:dopamine)
a(CHEBI:Anatabine) increases, decreases path(MESH:Anxiety)
path(HBP:"isolation rearing") increases, decreases r(RGD:Bdnf)
p(HGNC:MAPT, var("p.Ala152Thr")) decreases, causesNoChange p(HGNC:MAPT)
a(CHEBI:epoxomicin) increases, decreases p(HGNC:MAPT)
path(MESH:"Alcohol Drinking") increases, decreases, causesNoChange p(HGNC:ADNP)
a(CHEBI:rosiglitazone) increases, decreases a(CHEBI:"amyloid-beta")
p(MGI:Mapt, var("p.Pro301Leu")) increases, decreases p(MGI:Mapt)
p(HGNC:BACE1, frag("67_78")) increases, decreases a(HBP:"sAPP-alpha")
a(CHEBI:nicotine) increases, causesNoChange a(HBP:"alpha-4-containing nAChR")
path(MESH:"Alzheimer Disease") increases, decreases, association, positiveCorrelation a(CHEBI:"amyloid-beta")
p(HGNC:TNF) increases, causesNoChange p(HGNC:STAT3, pmod(Ph))
path(MESH:D060825) increases, causesNoChange p(HGNC:CHAT)
p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases, causesNoChange p(MGI:Mapt)
path(HBP:"isolation rearing") increases, decreases r(RGD:Ntrk2)
p(HGNC:BACE1) increases, decreases, causesNoChange, association p(HGNC:APP)
p(MGI:Tfeb) decreases, causesNoChange p(MGI:Mapt, pmod(Ph))
a(MESH:antalarmin) increases, decreases p(RGD:Drd3)
a(PUBCHEM:9832404) increases, decreases, causesNoChange, association p(HGNC:DLG4)
p(HBP:"Tau oligomers", var("p.Lys280del")) increases, causesNoChange bp(GO:"cell death")
a(CHEBI:Nilvadipine) increases, decreases a(CHEBI:"amyloid-beta polypeptide 42")
a(CHEBI:lactacystin) increases, decreases p(HGNC:MAPT)
bp(GO:macroautophagy) decreases, causesNoChange p(MGI:Mapt, var("p.Pro301Leu"))
a(CHEBI:"amyloid-beta") increases, decreases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
p(HGNC:HSPA1A) increases, decreases a(HBP:"Tau aggregates")
a(CHEBI:donepezil) increases, decreases p(HGNC:ACHE)
a(CHEBI:heparin) increases, decreases, causesNoChange a(HBP:"Tau aggregates")
a(CHEBI:"amyloid-beta") decreases, causesNoChange, positiveCorrelation, increases, association p(HGNC:CHRNA7)
p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation, decreases, causesNoChange a(MESH:Microglia)
p(HGNC:ACHE) increases, decreases, directlyIncreases a(CHEBI:acetylcholine)
path(MESH:"Alzheimer Disease") decreases, positiveCorrelation, negativeCorrelation, increases, association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
a(CHEBI:chlorobutanol) decreases, causesNoChange path(MESH:Smell)
a(HBP:HBP00092) increases, causesNoChange bp(GO:"apoptotic process")
complex(GO:"NF-kappaB complex") increases, decreases p(HGNC:BCL2L1)
a(HBP:"4-OH-GTS-21") decreases, causesNoChange a(MESH:"Cholinergic Neurons")
path(MESH:D000544) decreases, causesNoChange p(HGNC:ACHE)
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases, causesNoChange path(MESH:"Alcohol Drinking")
p(HGNC:SYK) increases, decreases a(CHEBI:"amyloid-beta")
a(PUBCHEM:11249342) increases, causesNoChange path(MESH:Vomiting)
a(GO:"neurofibrillary tangle") increases, decreases bp(GO:"cell death")
a(PUBCHEM:9832404) increases, causesNoChange p(HGNC:SLC17A7)
bp(GO:autophagy) increases, negativeCorrelation, decreases a(CHEBI:lipid)
a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases, decreases a(CHEBI:"amyloid-beta")
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases, causesNoChange path(MESH:"Motor Activity")
p(HGNC:AQP4) increases, decreases, association a(CHEBI:"amyloid-beta")
bp(GO:"lysosomal protein catabolic process") increases, decreases a(CHEBI:"amyloid-beta")
a(PUBCHEM:11249342) increases, causesNoChange path(MESH:Nausea)
complex(GO:"NF-kappaB complex") increases, decreases, regulates p(HGNC:BACE1)
bp(MESH:Autophagy) increases, decreases a(HBP:"Tau aggregates")
a(CHEBI:"methylene blue") increases, decreases p(HGNC:MARK4)
bp(GO:macroautophagy) increases, decreases p(MGI:Mapt)
a(HBP:HBP00055) increases, decreases p(MGI:Mapt)
bp(GO:"chaperone-mediated autophagy") increases, causesNoChange p(MGI:Mapt, var("p.Pro301Leu"))
a(MESH:antalarmin) increases, decreases r(RGD:Ntrk2)
a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases, decreases a(CHEBI:"amyloid-beta polypeptide 42")
bp(GO:aging) increases, negativeCorrelation, decreases p(HGNC:MAPT)
a(CHEBI:nicotine) decreases, causesNoChange, increases, association, regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
a(HBP:"amyloid-beta oligomers") increases, decreases p(HGNC:MAPT)
p(HGNC:BSG) decreases, causesNoChange a(CHEBI:"amyloid-beta")
p(MGI:Vegfc) increases, causesNoChange a(CHEBI:macromolecule)
p(FPLX:"CCT_complex") increases, decreases a(HBP:"huntingtin aggregates")
a(MESH:antalarmin) decreases, causesNoChange path(HBP:"isolation rearing")
a(CHEBI:"amyloid-beta") increases, decreases, positiveCorrelation complex(GO:"NF-kappaB complex")
a(CHEBI:nicotine) increases, causesNoChange, regulates p(FPLX:CHRN)
p(HGNC:APOE) increases, decreases, regulates a(CHEBI:"amyloid-beta")
a(PUBCHEM:675434) increases, decreases p(HGNC:MAPT)
p(HGNC:MAPT) increases, causesNoChange bp(GO:"retrograde axonal protein transport")
a(MESH:antalarmin) increases, decreases p(RGD:Drd2)
p(FPLX:mTORC1) increases, decreases bp(GO:macroautophagy)
composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases, decreases path(MESH:Smell)
a(CHEBI:sirolimus) increases, decreases p(HGNC:MAPT)
p(MGI:Crh) decreases, causesNoChange a(MESH:Progesterone)

Unstable Pairs 112

Chaotic Pairs
Nodes that mutually increase each other, such as when both A increases B and B increases A.
Dampened Pairs
Nodes that mutually decrease each other, such as when both A decreases B and B decreases A.

While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.

Type Node A Node B
Chaotic p(FPLX:NFkappaB) p(HGNC:IL1B)
Chaotic p(HGNC:HSF1) p(HGNC:HSF1)
Chaotic p(FPLX:NFkappaB) p(HGNC:TNF)
Chaotic p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))
Chaotic bp(GO:"astrocyte activation") p(HGNC:IL1B)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:IL1B)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7)
Chaotic a(MESH:Proteins) p(HGNC:PSMD14)
Chaotic a(CHEBI:acetylcholine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Chaotic a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:TREM2)
Chaotic a(HBP:"Tau oligomers") p(HGNC:MAPT)
Chaotic a(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease")
Chaotic p(HGNC:MAPT, pmod(Ac, Lys, 290)) p(HGNC:MAPT, pmod(Ac, Lys, 290))
Chaotic a(MESH:"Lymphatic Vessels") bp(MESH:"Cerebrovascular Circulation")
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:MMP3)
Chaotic p(MGI:"interleukin 1 alpha") p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:"calcium(2+)")
Chaotic a(CHEBI:dextran) a(CHEBI:dextran)
Chaotic a(CHEBI:"amyloid-beta polypeptide 42") r(HGNC:"BACE1-AS")
Chaotic a(CHEBI:acetylcholine) p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
Chaotic a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT)
Chaotic p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Chaotic a(CHEBI:nicotine) p(FPLX:PI3K)
Chaotic p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") p(MGI:"interleukin 1 alpha")
Chaotic a(CHEBI:"amyloid-beta") bp(GO:phagocytosis)
Chaotic bp(GO:"apoptotic process") p(HGNC:CASP6)
Chaotic a(MESH:"Lymphatic Vessels") p(MGI:Vegfc)
Chaotic p(HGNC:MAPT, pmod(Ac, Lys, 259)) p(HGNC:MAPT, pmod(Ac, Lys, 259))
Chaotic p(MGI:"oncostatin M") p(MGI:"signal transducer and activator of transcription 3")
Chaotic p(MGI:"interleukin 1 alpha") p(MGI:"signal transducer and activator of transcription 3")
Chaotic p(MESH:Proteins, pmod(Ub)) p(MESH:Proteins, pmod(Ub))
Chaotic a(MESH:Neurons) p(HGNC:MAPT)
Chaotic p(HGNC:PRNP) p(HGNC:PRNP)
Chaotic p(FPLX:NFkappaB) p(FPLX:NFkappaB)
Chaotic a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:BACE1)
Chaotic p(HGNC:ERN1) p(HGNC:ERN1, pmod(Ph))
Chaotic complex(GO:"NF-kappaB complex") p(HGNC:LIF)
Chaotic complex(GO:"NF-kappaB complex") p(HGNC:TNF)
Chaotic complex(GO:"filamentous actin") p(HGNC:MAPT)
Chaotic bp(GO:"chaperone-mediated autophagy") p(MGI:Mapt, var("p.Ala152Thr"))
Chaotic bp(GO:"astrocyte activation") p(HGNC:IL18)
Chaotic p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Chaotic complex(GO:"NF-kappaB complex") p(HGNC:IL6)
Chaotic a(CHEBI:nicotine) p(FPLX:"CAMK2_complex")
Chaotic p(HGNC:MAPT) p(HGNC:MAPT)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:MMP2)
Chaotic bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph, Ser, 262))
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:RELA)
Chaotic p(HGNC:MAPT, var("p.Pro301Ser")) p(HGNC:MAPT, var("p.Pro301Ser"))
Chaotic complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) p(HGNC:PPME1)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:MMP9)
Chaotic a(CHEBI:acetylcholine) p(HGNC:CHRM1)
Chaotic complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) p(HGNC:MAPT, pmod(Ph))
Chaotic bp(GO:"depolarization of postsynaptic membrane") bp(GO:"long-term synaptic potentiation")
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex")
Chaotic p(HGNC:MAPT, pmod(Ac, Lys, 321)) p(HGNC:MAPT, pmod(Ac, Lys, 321))
Chaotic p(HGNC:MAPT, pmod(Ph, Tyr, 18)) p(HGNC:SYK)
Chaotic complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) p(HGNC:UBA2)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:APOE)
Chaotic a(CHEBI:"reactive oxygen species") complex(GO:"NF-kappaB complex")
Chaotic complex(GO:"NF-kappaB complex") p(HGNC:CNTF)
Chaotic a(CHEBI:acetylcholine) bp(GO:"synaptic transmission, cholinergic")
Chaotic a(GO:lysosome) a(GO:lysosome)
Chaotic a(HBP:"Tau aggregates") a(HBP:"Tau aggregates")
Chaotic a(HBP:"Tau isoform F (441 aa)") a(HBP:"Tau isoform F (441 aa)")
Chaotic a(MESH:Proteins) a(MESH:Proteins)
Chaotic a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7)
Chaotic a(CHEBI:nicotine) p(HGNC:CHRNA7)
Chaotic bp(GO:"microglial cell activation") p(HGNC:IL1B)
Chaotic bp(GO:macroautophagy) p(MGI:Mapt, var("p.Ala152Thr"))
Chaotic a(CHEBI:nicotine) bp(GO:"ERK1 and ERK2 cascade")
Chaotic a(CHEBI:"amyloid-beta") p(FPLX:TLR)
Chaotic complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) p(HGNC:CDK5)
Chaotic p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Chaotic p(HBP:"N-terminal fragment of ATF6") p(HBP:"N-terminal fragment of ATF6")
Chaotic bp(GO:"microglial cell activation") p(HGNC:IL18)
Chaotic bp(GO:"chaperone-mediated autophagy") p(MGI:Mapt, var("p.Pro301Leu"))
Chaotic a(CHEBI:acetylcholine) a(CHEBI:choline)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:APP)
Chaotic p(HGNC:MAPT) p(HGNC:SQSTM1)
Chaotic a(CHEBI:acetylcholine) complex(a(CHEBI:acetylcholine), p(MESH:D011950))
Chaotic p(HGNC:MAPT, pmod(Ac, Lys, 353)) p(HGNC:MAPT, pmod(Ac, Lys, 353))
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NLRP3 inflammasome complex")
Dampened p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280))
Dampened p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
Dampened p(HBP:"UBB+1", pmod(UbPoly)) p(HBP:"UBB+1", pmod(UbPoly))
Dampened p(HBP:HBP00053, var("p.Lys280del")) p(HBP:HBP00053, var("p.Lys280del"))
Dampened p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
Dampened p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))
Dampened p(HGNC:MAPT, pmod(Ac, Lys, 163)) p(HGNC:MAPT, pmod(Ac, Lys, 163))
Dampened a(CHEBI:"amyloid-beta") a(CHEBI:nicotine)
Dampened p(HBP:"cis p-tau") p(HGNC:PIN1)
Dampened p(HBP:"cis p-tau") p(HBP:"cis p-tau")
Dampened a(HBP:"protein aggregates") bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
Dampened a(CHEBI:"amyloid-beta") p(HGNC:CHRM1)
Dampened a(CHEBI:"amyloid-beta") p(HGNC:BCL2L1)
Dampened a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7)
Dampened complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7))
Dampened bp(GO:autophagy) p(HGNC:MAPT)
Dampened p(HGNC:MAPT, pmod(Ac, Lys, 369)) p(HGNC:MAPT, pmod(Ac, Lys, 369))
Dampened a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine)
Dampened p(MGI:Mapt, var("p.Ala152Thr")) p(MGI:Mapt, var("p.Ala152Thr"))
Dampened p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))
Dampened a(HBP:"Tau aggregates") complex(GO:"proteasome complex")
Dampened p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
Dampened a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")
Dampened p(HGNC:SNCA, var("?")) p(HGNC:SNCA, var("?"))
Dampened complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))
Dampened a(CHEBI:acetylcholine) a(CHEBI:acetylcholine)
Dampened p(HGNC:MAPT, pmod(Ac, Lys, 281)) p(HGNC:MAPT, pmod(Ac, Lys, 281))
Dampened a(CHEBI:"amyloid-beta") complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
Dampened p(MGI:Mapt, var("p.Pro301Leu")) p(MGI:Mapt, var("p.Pro301Leu"))

Contradictory Triplets 1251

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both A positiveCorrelation B, B negativeCorrelation C, but C positiveCorrelation A.
Mutually Unstable Triplets
When both A negativeCorrelation B, B negativeCorrelation C, and C negativeCorrelation A.
Jens Contradictory Triplet
When A increases B, A decreases C, and C positiveCorrelation A.
Increase Mismatch Triplet
When A increases B, A increases C, and C negativeCorrelation A.
Decrease Mismatch Triplet
When A decreases B, A decreases C, and C negativeCorrelation A.
Type Node A Node B Node C
Separate path(MESH:"Alzheimer Disease") p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Thr, 231))
Separate p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:PIN1, pmod(Ph, Ser, 71))
Separate p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:PIN1, pmod(Ph, Ser, 71))
Separate a(CHEBI:"amyloid-beta") p(HGNC:CHRNA4) path(MESH:"Alzheimer Disease")
Separate p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub))
Separate p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub))
Separate path(MESH:"Alzheimer Disease") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
Separate p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:CHRNA4) path(MESH:"Alzheimer Disease")
Separate path(MESH:"Alzheimer Disease") complex(GO:"protein phosphatase type 2A complex") p(HGNC:SET, frag("?"))
Separate a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta polypeptide 42") path(MESH:"Alzheimer Disease")
Separate path(MESH:"Alzheimer Disease") bp(GO:"neuron death") bp(MESH:Autophagy)
Separate a(CHEBI:"amyloid-beta") bp(GO:endocytosis) path(MESH:"Alzheimer Disease")
Separate path(MESH:"Pick Disease of the Brain") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
Separate a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
Separate path(MESH:"Alzheimer Disease") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
Separate p(HGNC:CHRNA7) bp(GO:cognition) path(MESH:"Alzheimer Disease")
Separate p(HGNC:GSK3B) bp(GO:"apoptotic process") p(HGNC:MAPT, pmod(Ph, Ser, 396))
Separate path(MESH:"Alzheimer Disease") bp(GO:aging) p(HGNC:MAPT)
Separate path(MESH:"Alzheimer Disease") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
Separate p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
Separate path(MESH:"Alzheimer Disease") complex(GO:"protein phosphatase type 2A complex") p(HGNC:ANP32A)
Separate path(MESH:"Alzheimer Disease") p(HGNC:MAPT) path(MESH:Dementia)
Separate a(CHEBI:"amyloid-beta") p(HGNC:PICALM) path(MESH:"Alzheimer Disease")
Separate path(MESH:"Alzheimer Disease") p(HGNC:BAG1) p(HGNC:MAPT, pmod(Ph))
Separate path(MESH:"Alzheimer Disease") complex(GO:"protein phosphatase type 2A complex") p(HGNC:SET)
Separate path(MESH:"Pick Disease of the Brain") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
Separate path(MESH:"Alzheimer Disease") p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub))
Mutual bp(GO:aging) complex(GO:"proteasome complex") p(HGNC:MAPT)
Mutual bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") bp(GO:autophagy) path(MESH:"Alzheimer Disease")
Mutual bp(GO:"lysosomal protein catabolic process") bp(GO:endocytosis) path(MESH:"Alzheimer Disease")
Mutual bp(GO:"proteasomal protein catabolic process") bp(GO:autophagy) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta polypeptide 40") a(CHEBI:nicotine) a(HBP:"alpha-4 beta-2 nAChR")
Jens a(MESH:Microglia) bp(GO:"neuron death") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:sirolimus) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(GO:microtubule) a(HBP:"Tau oligomers") p(HGNC:MAPT)
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, var("p.Lys280del"))
Jens a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) a(CHEBI:choline)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") bp(GO:memory)
Jens p(HGNC:GSK3B) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") a(CHEBI:Nilvadipine)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HBP:"Tau aggregates")
Jens a(CHEBI:"okadaic acid") p(FPLX:PPP2) path(MESH:Neoplasms)
Jens p(HGNC:AK1) p(HGNC:APP) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:IL1B)
Jens p(HGNC:IL6) p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Ser, 214)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, frag("?")) p(HGNC:MAPT, pmod(Ph, Ser, 422)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"calcium(2+)") a(CHEBI:dopamine) a(HBP:HBP00093)
Jens a(CHEBI:"potassium(1+)") complex(GO:"inflammasome complex") p(HGNC:IL1B)
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") path(MESH:"Supranuclear Palsy, Progressive")
Jens p(FPLX:GSK3) p(HGNC:MAPT, pmod(Ph, Ser, 199)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:nilotinib) bp(GO:macroautophagy) p(HGNC:ABL1)
Jens a(MESH:Neurons) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"3',5'-cyclic AMP") a(CHEBI:rolipram) p(HGNC:MAPT)
Jens p(FPLX:CALM) p(HBP:"DAPK, basic loop (BL) motif") p(HGNC:DAPK2)
Jens bp(MESH:"Oxidative Stress") p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jens complex(p(HGNC:FYN), p(HGNC:MAPT)) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:WNT3A)
Jens a(CHEBI:"amyloid-beta") bp(GO:"canonical Wnt signaling pathway") p(HGNC:DKK1)
Jens p(HGNC:MAPT) p(HGNC:MAPT, var("?")) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:RELA)
Jens bp(GO:"neuron death") p(HGNC:IL6) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") g(HBP:"APOE e4") p(HGNC:APP)
Jens a(CHEBI:"amyloid-beta") a(HBP:HBP00018) p(HGNC:TFEB)
Jens bp(GO:aging) p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:sirolimus) bp(GO:cognition) path(MESH:"Alzheimer Disease")
Jens a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens p(HGNC:GSK3B) p(HGNC:MAPT) p(HGNC:SYK)
Jens a(HBP:"Tau aggregates") a(HBP:"Tau oligomers") path(MESH:Tauopathies)
Jens p(FPLX:PPP2) p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) path(MESH:"Alzheimer Disease")
Jens bp(GO:macroautophagy) p(HGNC:MAPT, var("p.Ala152Thr")) p(MGI:Mapt)
Jens p(HGNC:DAPK1) p(HGNC:MAPT) p(HGNC:PIN1, pmod(Ph, Ser, 71))
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ph))
Jens p(HGNC:ABL1) p(HGNC:MAPT, pmod(Ph, Tyr, 394)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:galanthamine) bp(GO:"synaptic transmission, cholinergic") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") complex(GO:"NLRP3 inflammasome complex")
Jens bp(GO:locomotion) composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:MMP2)
Jens p(HGNC:CDK2) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens p(FPLX:ERK) p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens bp(GO:"axonal transport") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(HBP:Neurodegeneration)
Jens p(HGNC:CDC37) p(HGNC:MAPT) p(HGNC:MAPT)
Jens m(MIRBASE:"hsa-mir-146a") p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
Jens p(HGNC:FKBP5) p(HGNC:MAPT, pmod(Ph, Ser, 396)) path(MESH:"Alzheimer Disease")
Jens a(GO:"neurofibrillary tangle") p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:Tauopathies)
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:BACE1)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, var("?")) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(MESH:Synapses) p(FPLX:PI3K)
Jens a(CHEBI:nicotine) bp(MESH:Neuroprotection) p(HGNC:CHRNA7)
Jens p(FPLX:GSK3) p(HGNC:MAPT, pmod(Ph, Ser, 404)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:donepezil) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(MESH:Microglia) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") bp(GO:"cerebrospinal fluid circulation") bp(GO:aging)
Jens a(CHEBI:Thrombin) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(MESH:methyllycaconitine) bp(MESH:Neuroprotection) p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta") bp(GO:"JNK cascade") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:CHRM1)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:Anatabine) p(HGNC:CHRNA7)
Jens a(GO:lysosome) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens complex(GO:"protein phosphatase type 2A complex") p(FPLX:ERK) p(HGNC:MAPT, pmod(Ph))
Jens a(CHEBI:"reactive oxygen species") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:GSK3B) p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:"amyloid-beta polypeptide 40") a(CHEBI:nicotine) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jens a(CHEBI:nicotine) bp(GO:memory) p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta") a(GO:synapse) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jens a(CHEBI:"amyloid-beta") bp(GO:aging) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) path(MESH:Anxiety)
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 396)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:aging) p(HGNC:IL1B)
Jens p(HGNC:FKBP5) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:sirolimus) bp(MESH:Autophagy) p(HGNC:MAPT, pmod(Ph))
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph))
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:BCL2)
Jens a(CHEBI:"amyloid-beta") bp(GO:"cell death") p(HGNC:CHRNA7)
Jens a(GO:lysosome) g(HGNC:APP, var("?")) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT) p(HGNC:OTUB1)
Jens a(CHEBI:"methylene blue") a(HBP:"Tau aggregates") bp(MESH:Autophagy)
Jens p(MGI:Mapt, var("p.Pro301Leu")) p(MGI:Mapt, var("p.Pro301Leu")) p(MGI:Mapt, var("p.Pro301Leu"))
Jens a(HBP:"protein aggregates") bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:scopolamine) a(MESH:VU0357017) bp(GO:"behavioral fear response")
Jens a(CHEBI:"amyloid-beta") bp(GO:"Fas signaling pathway") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:MMP9)
Jens a(CHEBI:peroxynitrite) bp(GO:"inflammatory response") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease") path(MESH:"Plaque, Amyloid")
Jens p(FPLX:NFkappaB) p(HGNC:BACE1) p(HGNC:UCHL1)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:Tauopathies)
Jens p(HGNC:GSK3B) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:PPP1CA)
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Thr, 205)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDK2) p(HGNC:MAPT, pmod(Ph, Ser, 404)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens a(MESH:Neurons) a(PUBCHEM:64627) p(MGI:Adora1)
Jens a(CHEBI:cilostazol) bp(GO:macroautophagy) p(HGNC:MAPT, pmod(HBP:HBP00007))
Jens p(HGNC:SNCA, var("?")) p(HGNC:SNCA, var("?")) p(HGNC:SNCA, var("?"))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
Jens a(CHEBI:"amyloid-beta") bp(GO:autophagy) p(HGNC:MAPK8)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:Anatabine) path(MESH:Anxiety)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:donepezil) p(HGNC:LRP1)
Jens a(PUBCHEM:9832404) bp(GO:"synaptic transmission, glutamatergic") p(HGNC:ADNP)
Jens bp(GO:autophagy) p(HGNC:APP) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(MESH:Astrocytes) p(HGNC:IL1B)
Jens p(HGNC:MAPT, pmod(Ub)) path(MESH:"Alzheimer Disease") path(MESH:"Neurofibrillary Tangles")
Jens bp(GO:"MAPK cascade") p(HBP:"alpha-4 beta-2 nAChR") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:sirolimus) bp(MESH:Autophagy) p(HGNC:MAPT)
Jens a(GO:lysosome) a(HBP:"Tau aggregates") path(MESH:"Alzheimer Disease")
Jens bp(GO:"depolarization of postsynaptic membrane") complex(GO:"voltage-gated calcium channel complex") p(HBP:"alpha-4 beta-2 nAChR")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:APP)
Jens a(MESH:Proteins) a(MESH:Proteins) a(MESH:Proteins)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:rivastigmine) p(HGNC:ABCB1)
Jens bp(GO:"neuron death") p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:TREM2)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) a(HBP:"alpha-4 beta-2 nAChR")
Jens a(MESH:Proteins) a(MESH:Proteins) p(HGNC:PSMD14)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:TFEB)
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta") p(HGNC:IL6) path(MESH:"Alzheimer Disease")
Jens p(FPLX:PPP2) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:autophagy) p(HGNC:TFEB)
Jens a(CHEBI:sirolimus) bp(MESH:Autophagy) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"proteasome inhibitor") p(HGNC:BAG3) p(HGNC:MAPT)
Jens bp(GO:"chaperone-mediated autophagy") p(MGI:Mapt, var("p.Pro301Leu")) p(MGI:Mapt, var("p.Pro301Leu"))
Jens a(CHEBI:ceramide) complex(GO:"protein phosphatase type 2A complex") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:pioglitazone) bp(GO:memory)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) path(HBP:neurotoxicity)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CASP3) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") p(HGNC:CHRM1)
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta") r(HGNC:BACE1)
Jens a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") bp(GO:"synaptic transmission, cholinergic") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:rosiglitazone) bp(GO:memory)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:MMP3)
Jens a(CHEBI:"amyloid-beta") complex(GO:"inflammasome complex") p(HGNC:IL18)
Jens p(HGNC:DAPK1) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ac, Lys, 290)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CAPN2) path(MESH:"Alzheimer Disease") path(MESH:"Neurofibrillary Tangles")
Jens p(HGNC:CHRNA4) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:chlorobutanol) a(PUBCHEM:9832404) path(MESH:Smell)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(FPLX:PI3K)
Jens bp(MESH:Aging) p(FPLX:HSP90) p(HGNC:STIP1)
Jens a(CHEBI:"amyloid-beta") p(FPLX:Proteasome) path(HBP:neurotoxicity)
Jens bp(GO:autophagy) p(HGNC:HSPB1) p(HGNC:MAPT)
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) complex(a(CHEBI:acetylcholine), p(MESH:D011950))
Jens a(CHEBI:staurosporine) bp(GO:"apoptotic process") p(HGNC:CDK5)
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) a(CHEBI:choline)
Jens a(MESH:Microglia) complex(GO:"NF-kappaB complex") p(HGNC:TNF)
Jens a(CHEBI:heparin) a(HBP:"Tau aggregates") a(HBP:"Tau aggregates")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:PICALM)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:oleocanthal) p(HGNC:LRP1)
Jens p(HBP:"cis p-tau") p(HBP:"cis p-tau") p(HBP:"cis p-tau")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) bp(GO:"long-term synaptic potentiation")
Jens a(CHEBI:"amyloid-beta") bp(GO:aging) p(HGNC:SYK)
Jens p(HGNC:PRKN) p(HGNC:SNCA) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:BCL2L1)
Jens complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease") path(MESH:"Plaque, Amyloid")
Jens a(HBP:"Corticobasal Degeneration") a(HBP:"Tau oligomers") a(HBP:"Tau oligomers")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Chronic Traumatic Encephalopathy")
Jens a(CHEBI:donepezil) p(HGNC:ACHE) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:aging) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau epitope, PHF1") p(HGNC:GSK3B) p(HGNC:MAPT)
Jens a(HBP:"Tau aggregates") a(HBP:"Tau oligomers") p(HGNC:MAPT, pmod(Ph))
Jens a(CHEBI:"amyloid-beta") p(HGNC:BACE1) p(HGNC:SYK)
Jens p(FPLX:GSK3) p(HGNC:MAPT, pmod(Ph, Ser, 396)) path(MESH:"Alzheimer Disease")
Jens p(MGI:Rela, pmod(Ph)) p(MGI:Stat3, pmod(Ph)) path(MESH:Encephalomyelitis)
Jens a(CHEBI:"iron(0)") p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") bp(MESH:Autophagy) p(HGNC:MAPT, pmod(Ph))
Jens p(HGNC:SNCA) p(HGNC:SNCA, pmod(Ub)) path(MESH:"Parkinson Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) p(HGNC:CHRM1)
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) p(HGNC:CHAT)
Jens a(CHEBI:"methylene blue") bp(GO:autophagy) p(HGNC:MAPT)
Jens p(FPLX:NFkappaB) p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Jens p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") p(MGI:"interleukin 1 alpha") path(MESH:Glioblastoma)
Jens bp(GO:autophagy) p(HGNC:HDAC6) p(HGNC:MAPT)
Jens a(PUBCHEM:675434) p(HGNC:MAPT) p(HGNC:MAPT)
Jens complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) p(HGNC:PPP2CA, pmod(Me, Leu, 309)) p(HGNC:PTPA)
Jens p(HGNC:PRNP) p(HGNC:PRNP) p(HGNC:PRNP)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:sirolimus) p(HGNC:MAPT)
Jens bp(GO:endocytosis) p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") p(HGNC:APP)
Jens p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease") path(MESH:Inflammation)
Jens complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT) p(HGNC:MAPT, var("?"))
Jens a(GO:lysosome) a(HBP:"Tau aggregates") path(HBP:Neurodegeneration)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 353)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, frag("?")) path(MESH:Tauopathies)
Jens a(CHEBI:"reactive oxygen species") bp(GO:"inflammatory response") p(FPLX:NFkappaB)
Jens a(GO:"neurofibrillary tangle") p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 163)) p(HGNC:MAPT, pmod(Ac, Lys, 163)) p(HGNC:MAPT, pmod(Ac, Lys, 163))
Jens a(CHEBI:"amyloid-beta") bp(MESH:"Oxidative Stress") path(MESH:"Alzheimer Disease")
Jens p(HGNC:APP) p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDC37) p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") p(HGNC:CHRNA7)
Jens a(CHEBI:"okadaic acid") complex(GO:"protein phosphatase type 2A complex") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens p(HGNC:APP, frag("672_713")) p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Jens bp(GO:"chaperone-mediated autophagy") p(MGI:Mapt, var("p.Ala152Thr")) p(MGI:Mapt, var("p.Ala152Thr"))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") a(MESH:Microglia)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) a(MESH:D002800)
Jens a(CHEBI:"amyloid-beta") bp(GO:phagocytosis) complex(GO:"NLRP3 inflammasome complex")
Jens a(HBP:HBP00074) bp(GO:"neuron death") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:CASP1) p(HGNC:IL18)
Jens a(CHEBI:"amyloid-beta") p(HGNC:ABCB1) path(MESH:"Alzheimer Disease")
Jens bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") p(HGNC:MAPT) p(HGNC:SQSTM1)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(HBP:"Tau epitope, PHF1")
Jens bp(GO:"microtubule polymerization") complex(GO:microtubule) p(HGNC:MAPT)
Jens a(HBP:HBP00018) a(HBP:HBP00030) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:IL1B)
Jens a(CHEBI:galanthamine) p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta") p(HGNC:SYK)
Jens a(CHEBI:bortezomib) p(FPLX:PPP2C) p(HGNC:CIP2A)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:donepezil) p(HGNC:CHRNA7)
Jens p(HGNC:CDK1) p(HGNC:MAPT, pmod(Ph, Thr, 231)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") bp(GO:"lysosomal protein catabolic process")
Jens a(CHEBI:"amyloid-beta") bp(GO:autophagy) complex(GO:"inflammasome complex")
Jens a(CHEBI:sirolimus) bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph))
Jens a(MESH:Brain) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens complex(GO:axon) p(HGNC:MAPT) p(HGNC:MAPT)
Jens bp(GO:"response to misfolded protein") p(HGNC:ERN1) p(HGNC:XBP1)
Jens a(HBP:"Tau aggregates") a(HBP:"Tau oligomers") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) p(HBP:"alpha-4 beta-2 nAChR")
Jens a(CHEBI:"amyloid-beta") p(HGNC:APP) p(HGNC:WNT3A)
Jens p(HGNC:CDK1) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNC:ACHE)
Jens a(CHEBI:"amyloid-beta") p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:MARK4) path(MESH:"Alzheimer Disease")
Jens complex(GO:"proteasome complex") p(HGNC:MAPT) p(HGNC:SQSTM1)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(MESH:Microglia) bp(GO:phagocytosis)
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") p(HGNC:HSPA1A)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(HBP:HBP00018) p(HGNC:IDE)
Jens a(CHEBI:"calcium(2+)") a(CHEBI:"glutamate(2-)") p(HGNC:CHRNA7)
Jens a(CHEBI:lactacystin) p(FPLX:Proteasome) p(HGNC:MAPT)
Jens a(CHEBI:"nitric oxide") a(CHEBI:peroxynitrite) complex(GO:"NF-kappaB complex")
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:"advanced glycation end-product") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(HBP:"Tau oligomers") complex(GO:axon) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") path(MESH:"Diabetes Mellitus")
Jens a(CHEBI:rivastigmine) bp(GO:cognition) path(MESH:"Alzheimer Disease")
Jens bp(GO:macroautophagy) p(MGI:Mapt) p(MGI:Mapt, var("p.Pro301Leu"))
Jens a(CHEBI:"amyloid-beta") p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Jens a(GO:"neurofibrillary tangle") bp(GO:"apoptotic process") p(HGNC:NFKB1)
Jens a(CHEBI:"amyloid-beta") bp(GO:memory) p(HGNC:CHRNA7)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(OGlyco)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) p(HGNC:CHRM1)
Jens a(CHEBI:"amyloid-beta polypeptide 42") bp(MESH:Neuroprotection) complex(GO:"NF-kappaB complex")
Jens complex(p(HGNC:GSK3B), p(HGNC:MAPT)) p(HGNC:GSK3B) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") p(FPLX:JNK) p(HGNC:AGER)
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine)
Jens complex(p(HGNC:APP), p(HGNC:HSD17B10)) p(HGNC:HSD17B10) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(GO:lysosome) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
Jens a(CHEBI:chloroquine) bp(GO:autophagy) p(HGNC:SQSTM1)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(MESH:Microglia) complex(GO:"NF-kappaB complex")
Jens a(GO:presynapse) a(PUBCHEM:64627) p(MGI:Adora1)
Jens p(HGNC:BACE1) p(HGNC:NGFR) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT) path(MESH:"Pick Disease of the Brain")
Jens a(CHEBI:"amyloid-beta") bp(MESH:"Oxidative Stress") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta") p(HGNC:IDE) path(MESH:"Alzheimer Disease")
Jens bp(GO:"neuron death") p(HGNC:CASP3) path(MESH:"Alzheimer Disease")
Jens bp(GO:aging) p(HGNC:FKBP5) p(HGNC:MAPT)
Jens a(CHEBI:"trichostatin A") p(FPLX:HDAC) p(HGNC:MAPT, pmod(Ac))
Jens bp(GO:"apoptotic process") bp(MESH:"Oxidative Stress") p(HGNC:GSK3B)
Jens a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) bp(GO:memory)
Jens bp(MESH:Aging) p(FPLX:Proteasome) path(MESH:"Protein Aggregation, Pathological")
Jens a(CHEBI:"amyloid-beta") a(GO:synapse) path(MESH:"Plaque, Amyloid")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) p(HGNC:CHRNA7)
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") complex(GO:"NLRP3 inflammasome complex") p(HGNC:IL18)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:donepezil) p(HGNC:ABCB1)
Jens a(CHEBI:chloroquine) p(HGNC:MAPT) p(HGNC:SQSTM1)
Jens a(GO:"neurofibrillary tangle") p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) p(MGI:Mapt)
Jens a(CHEBI:acetylcholine) a(CHEBI:galanthamine) p(HGNC:ACHE)
Jens a(CHEBI:"amyloid-beta") p(HGNC:NGFR) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"calcium(2+)") p(HGNC:MAPT) p(HGNCGENEFAMILY:Calpains)
Jens a(MESH:Proteins) bp(GO:endocytosis) p(HGNC:RAB5A)
Jens a(CHEBI:"methylene blue") a(HBP:"Tau aggregates") bp(GO:macroautophagy)
Jens a(CHEBI:"amyloid-beta") bp(GO:"response to oxidative stress") bp(GO:autophagy)
Jens a(HBP:HBP00018) p(HGNC:IDE) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) path(MESH:"Alzheimer Disease") path(MESH:"Plaque, Amyloid")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:rivastigmine) p(HGNC:LRP1)
Jens a(MESH:Hippocampus) p(HGNC:CHRNA7) path(MESH:Schizophrenia)
Jens bp(GO:"MAPK cascade") p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens complex(GO:"NF-kappaB complex") p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Jens p(HGNC:IL1B) path(MESH:"Alzheimer Disease") path(MESH:Dementia)
Jens a(CHEBI:nicotine) bp(GO:"ERK1 and ERK2 cascade") bp(GO:"apoptotic process")
Jens a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Jens a(CHEBI:"okadaic acid") p(HGNC:MAPT, pmod(Ph)) p(HGNC:PPP2CA)
Jens p(HGNC:BAG1) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:geldanamycin) p(FPLX:HSP90) p(HGNC:HSF1)
Jens a(CHEBI:"amyloid-beta") a(MESH:"Lymphatic Vessels") bp(GO:aging)
Jens a(HBP:"amyloid-beta oligomers") p(FPLX:Proteasome) path(HBP:neurotoxicity)
Jens a(CHEBI:palbociclib) a(HBP:"Tau isoform F (441 aa)") p(HGNC:CDK6)
Jens a(GO:mitochondrion) bp(MESH:"Oxidative Stress") p(HGNC:GLP1R)
Jens a(HBP:"Tau aggregates") complex(GO:"proteasome complex") p(HGNC:MAPT)
Jens bp(GO:memory) p(HGNC:BACE1) p(HGNC:UCHL1)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:Nilvadipine) p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jens a(CHEBI:epoxomicin) p(HGNC:CASP3) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) bp(GO:memory)
Jens a(HBP:"Tau isoform F (441 aa)") a(HBP:"Tau isoform F (441 aa)") a(HBP:"phosphatase-activating domain")
Jens a(MESH:Astrocytes) p(HGNC:APP) p(HGNC:IL1B)
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub)) path(MESH:"Alzheimer Disease")
Jens a(GO:presynapse) a(HBP:"Tau aggregates") a(MESH:"BSc 3094")
Jens a(CHEBI:"amyloid-beta") p(HGNC:APP) p(HGNC:IL1B)
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")
Jens a(HBP:HBP00074) p(HGNC:NGFR) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta polypeptide 42") complex(GO:"NF-kappaB complex")
Jens bp(MESH:Aging) p(FPLX:HSP90) path(MESH:"Protein Aggregation, Pathological")
Jens a(CHEBI:donepezil) p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta") a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") bp(GO:memory)
Jens a(CHEBI:acetylcholine) a(CHEBI:galanthamine) path(MESH:"Alzheimer Disease")
Jens path(MESH:"Alzheimer Disease") path(MESH:"Cognitive Dysfunction") path(MESH:"Plaque, Amyloid")
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 199)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"okadaic acid") bp(GO:cognition) p(HGNC:MAPT, pmod(Ph))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(MGI:Syk)
Jens complex(GO:"protein phosphatase type 2A complex") p(FPLX:ERK) path(MESH:"Alzheimer Disease")
Jens a(MESH:Trehalose) bp(MESH:Autophagy) p(HGNC:MAPT)
Jens p(HBP:"CDK5R1 p25") p(HBP:"Tau epitope, AT8") p(MGI:Cdk5)
Jens a(CHEBI:"amyloid-beta") bp(GO:"MAPK cascade") path(MESH:"Alzheimer Disease")
Jens p(HGNC:FKBP5) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens complex(a(GO:microtubule), p(HGNC:MAPT)) complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) p(HGNC:MAPT, pmod(Ph))
Jens bp(GO:"axonal transport") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:Temsirolimus) bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:oleocanthal) p(HGNC:ABCB1)
Jens bp(MESH:Autophagy) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
Jens a(PUBCHEM:164676) p(FPLX:IKB) p(FPLX:NFkappaB)
Jens bp(GO:learning) complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:IL18) path(MESH:"Alzheimer Disease")
Jens a(HBP:HBP00093) bp(GO:autophagy) p(HGNC:TFEB)
Jens bp(GO:aging) p(HGNC:FKBP5) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jens a(CHEBI:"amyloid-beta") p(HGNC:MAPT) p(HGNC:SYK)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO)))
Jens bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph)) path(HBP:Neurodegeneration)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:resveratrol) p(FPLX:AMPK)
Jens a(CHEBI:"amyloid-beta") bp(GO:endocytosis) g(HBP:"APOE e4")
Jens p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:PIN1, pmod(Ph, Ser, 71))
Jens p(HGNC:GSK3B) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Thr, 205))
Jens p(MGI:Mapt, var("p.Ala152Thr")) p(MGI:Mapt, var("p.Ala152Thr")) p(MGI:Mapt, var("p.Ala152Thr"))
Jens a(CHEBI:acetylcholine) a(CHEBI:nicotine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(MESH:Kidney)
Jens p(HGNC:BACE1) p(HGNC:RELA) path(MESH:"Alzheimer Disease")
Jens a(HBP:"amyloid-beta aggregates") path(HBP:"mitochondrial dysfunction") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:"apoptotic process") p(HGNC:BCL2L1)
Jens a(CHEBI:"amyloid-beta") bp(GO:"long-term synaptic potentiation") p(HGNC:RELA)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) bp(GO:"neuron death")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex")
Jens a(HBP:"Tau oligomers") bp(MESH:Autophagy) path(MESH:"Alzheimer Disease")
Jens p(FPLX:PKA) p(HGNC:MAPT, pmod(Ph, Ser, 202)) p(HGNC:SYK)
Jens a(CHEBI:"dimethyl fumarate") p(FPLX:ERK) p(HGNC:MAPT, pmod(Ph))
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") a(HBP:"Tau oligomers")
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, pmod(Ph))
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, var("p.Asn279Lys"))
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:IL6)
Jens a(CHEBI:"amyloid-beta") p(HGNC:CHRNA3) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 369)) p(HGNC:MAPT, pmod(Ac, Lys, 369)) p(HGNC:MAPT, pmod(Ac, Lys, 369))
Jens a(CHEBI:"amyloid-beta") bp(MESH:"Oxidative Stress") p(HGNC:MAPT)
Jens a(CHEBI:"alpha,alpha-trehalose") p(HGNC:BAG3) p(HGNC:MAPT)
Jens a(HBP:"amyloid-beta oligomers") p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jens a(CHEBI:"amyloid-beta") p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:donepezil) p(HGNC:CHRNA4) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:BCL2L1)
Jens complex(a(GO:microtubule), p(HGNC:MAPT)) complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) p(HGNC:MAPT, pmod(Ph))
Jens a(CHEBI:"amyloid-beta") p(HGNC:BACE1) p(HGNC:CHRM1)
Jens a(HBP:"Tau isoform F (441 aa)") a(HBP:"Tau isoform F (441 aa)") a(HBP:"Tau isoform F (441 aa)")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(FPLX:NFkappaB)
Jens p(FPLX:PPP2) p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) path(MESH:"Alzheimer Disease")
Jens bp(GO:macroautophagy) p(FPLX:mTORC1) p(HGNC:SIRT1)
Jens bp(GO:"anterograde axonal protein transport") p(HBP:"6D tau", frag("2_18")) p(MESH:"Glycogen Synthase Kinase 3")
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") p(HBP:"phosphatase-activating domain")
Jens p(HGNC:BAG1) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(MESH:Microglia) p(HGNC:IL1B)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7)
Jens p(HGNC:MAPT) p(HGNC:MAPT, frag("?")) path(HBP:Neurodegeneration)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 321)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:autophagy) p(HGNC:APP)
Jens bp(GO:"clathrin-dependent endocytosis") p(HGNC:MAPT) p(HGNC:MAPT)
Jens bp(MESH:Aging) bp(MESH:Proteolysis) p(FPLX:HSP90)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 281)) p(HGNC:MAPT, pmod(Ac, Lys, 281)) p(HGNC:MAPT, pmod(Ac, Lys, 281))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(MGI:Chrna7)
Jens p(HGNC:CHRNA4) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau oligomers") a(MESH:Neurons) p(HGNC:MAPT)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 321)) p(HGNC:MAPT, pmod(Ac, Lys, 321)) p(HGNC:MAPT, pmod(Ac, Lys, 321))
Jens a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7) p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, var("p.Val337Met"))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNC:BAX)
Jens a(HBP:"Tau aggregates") bp(GO:aging) p(HGNC:SYK)
Jens a(MESH:Nicotine) p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:scopolamine) a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") bp(GO:"behavioral fear response")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:sirolimus) bp(GO:autophagy)
Jens p(FPLX:NFkappaB) p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:metformin) bp(GO:autophagy)
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNC:BCL2)
Jens p(FPLX:NFkappaB) p(HGNC:IL18) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"okadaic acid") complex(GO:"protein phosphatase type 2A complex") p(HGNC:MAPT, pmod(Ph))
Jens p(FPLX:ERK) p(HGNC:MAPT, pmod(Ph, Ser, 396)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:memory) complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") bp(MESH:Neuroprotection)
Jens a(CHEBI:"methylene blue") bp(MESH:Autophagy) p(HGNC:MAPT, pmod(Ph))
Jens bp(GO:autophagy) p(FPLX:mTORC1) p(HGNC:MAPT)
Jens bp(GO:"neuron death") complex(GO:"NF-kappaB complex") p(HGNC:IL6)
Jens a(CHEBI:"amyloid-beta") p(FPLX:NFkappaB) p(HGNC:IL1B)
Jens a(GO:"neurofibrillary tangle") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens a(MESH:"Amyloid beta-Peptides") p(HGNC:BECN1) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDC37) p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 199))
Jens p(HGNC:GSK3B) p(HGNC:GSK3B, pmod(Ph, Ser, 9)) p(HGNC:PPP1CA)
Jens a(CHEBI:rolipram) complex(GO:"proteasome complex") p(HGNC:MAPT)
Jens a(PUBCHEM:675434) p(HGNC:MAPT) p(HGNC:USP14)
Jens a(CHEBI:nicotine) p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jens a(HBP:HBP00089) bp(GO:"microglial cell activation") p(HGNC:CCL2)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")
Jens a(CHEBI:"amyloid-beta") bp(GO:"long-term synaptic potentiation") p(HGNC:CHRM1)
Jens a(CHEBI:"amyloid-beta") bp(GO:"long-term synaptic potentiation") p(MGI:Chrm1)
Jens a(CHEBI:acetylcholine) a(MESH:"Cholinergic Neurons") bp(GO:memory)
Jens p(HGNC:CHRNA7) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:cilostazol) bp(GO:macroautophagy) p(FPLX:mTORC1)
Jens a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") p(MGI:App, frag("25_35")) path(MESH:"Spatial Memory")
Jens bp(GO:aging) p(HGNC:MAPT) p(HGNC:MAPT)
Jens p(HGNC:FKBP5) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:dopamine) a(HBP:HBP00093) path(MESH:"Parkinson Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:tanespimycin) bp(GO:memory)
Jens bp(GO:"apoptotic process") p(HGNC:CDK5) p(HGNC:MAPK1)
Jens a(MESH:"Cholinergic Neurons") path(MESH:"Alzheimer Disease") path(MESH:Apathy)
Jens a(MESH:"Amyloid beta-Peptides") complex(GO:"NF-kappaB complex") p(HGNC:TNF)
Jens a(GO:"neurofibrillary tangle") p(HGNC:MAPT, pmod(Ph)) p(HGNC:TNF)
Jens bp(GO:"proteasomal protein catabolic process") p(HGNC:HSPB1) p(HGNC:MAPT)
Jens bp(GO:memory) complex(GO:"NF-kappaB complex") p(HGNC:BACE1)
Jens a(GO:"neurofibrillary tangle") p(HGNC:CDKN2A) path(MESH:"Supranuclear Palsy, Progressive")
Jens p(HGNC:FYN) p(HGNC:MAPT, pmod(Ph, Tyr, 18)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") bp(GO:aging) path(MESH:"Alzheimer Disease")
Jens a(PUBCHEM:155160) bp(GO:memory) p(HGNC:BACE1)
Jens a(PUBCHEM:675434) p(FPLX:Proteasome) p(HGNC:USP14)
Jens a(CHEBI:"alpha,alpha-trehalose") a(CHEBI:"amyloid-beta") bp(GO:macroautophagy)
Jens a(CHEBI:wortmannin) bp(GO:autophagy) p(HGNC:MAPT)
Jens p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(NGlyco)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") bp(HBP:neurotoxicity)
Jens p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:MAPT)
Jens p(HGNC:CDK5) p(HGNC:IL18) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") bp(GO:aging) p(HGNC:MAPT)
Jens complex(GO:"inflammasome complex") p(HGNC:CASP1) p(HGNC:IL18)
Jens complex(GO:"filamentous actin") p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(MESH:D002800) bp(GO:"GO:0014047") path(MESH:D000544)
Jens a(CHEBI:"amyloid-beta") bp(MESH:"Neuronal Outgrowth") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"potassium(1+)") p(HGNC:IL1B) p(HGNC:PYCARD)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") a(CHEBI:rosiglitazone)
Jens p(HGNC:CDC37) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jens a(CHEBI:"okadaic acid") p(FPLX:PPP2) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease") path(MESH:Anxiety)
Jens a(GO:"neurofibrillary tangle") complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ph)) p(HGNC:MAPT, pmod(Sumo, Lys, 340)) p(HGNC:MAPT, pmod(Ub))
Jens a(CHEBI:"amyloid-beta") p(HGNC:AGER) path(MESH:"Alzheimer Disease")
Jens p(HGNC:HMOX1) p(HGNC:NFE2L2) path(MESH:"Alzheimer Disease")
Jens bp(GO:autophagy) p(HGNC:MAPT) path(HBP:neurotoxicity)
Jens bp(GO:"neuron death") complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"D-ribose") a(HBP:"advanced glycation end product") p(HGNC:MAPT, pmod(Ph, Thr, 181))
Jens a(CHEBI:"amyloid-beta") a(HBP:HBP00038) complex(GO:"NLRP3 inflammasome complex")
Jens p(FPLX:ERK) p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:"MAPK cascade") p(HGNC:CHRNA7)
Jens p(HGNC:CTSD) p(HGNC:MAPT) path(HBP:neurotoxicity)
Jens complex(a(GO:microtubule), p(HGNC:MAPT)) p(FPLX:HSP90) p(HGNC:MAPT, pmod(Ph))
Jens a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") bp(GO:"ERK1 and ERK2 cascade") bp(GO:"apoptotic process")
Jens p(HGNC:CDC37) p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:Temsirolimus) bp(GO:autophagy)
Jens a(GO:microtubule) bp(GO:"anterograde axonal transport") p(HGNC:MAPT)
Jens a(HBP:"amyloid-beta oligomers") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens p(HGNC:CAPN1) p(HGNC:CAST) p(HGNC:HTT, var("?"))
Jens bp(GO:autophagy) p(FPLX:mTORC1) p(HGNC:TFEB)
Jens p(HGNC:MAPT) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens complex(GO:"NF-kappaB complex") p(HGNC:BACE1) p(HGNC:TNF)
Jens a(GO:"neurofibrillary tangle") p(ECCODE:"2.3.2.13") path(MESH:"Supranuclear Palsy, Progressive")
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") a(HBP:neuroinflammation)
Jens a(CHEBI:"amyloid-beta") bp(GO:endocytosis) p(HGNC:RAB5A)
Jens bp(GO:"long-term synaptic potentiation") p(HGNC:MAPT) p(HGNC:MAPT)
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Thr, 181)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT) p(HGNC:MAPT, var("p.Ala152Thr"))
Jens a(CHEBI:"amyloid-beta") bp(GO:autophagy) p(HGNC:BIN1)
Jens bp(GO:memory) complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")
Jens bp(GO:macroautophagy) p(FPLX:mTORC1) p(HGNC:MAPT)
Jens bp(GO:macroautophagy) p(FPLX:mTORC1) p(HGNC:TFEB)
Jens p(HGNC:CDK2) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ph, Ser, 422)) path(MESH:"Alzheimer Disease") path(MESH:"Cognitive Dysfunction")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT) p(HGNC:SYK)
Jens a(CHEBI:acetylcholine) p(HGNC:BCHE) path(MESH:"Alzheimer Disease")
Jens bp(GO:cognition) p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") p(MGI:Crhr1)
Jens a(CHEBI:"amyloid-beta") p(HGNC:BCL2) p(HGNC:TNF)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(MESH:Microglia) bp(GO:"positive regulation of advanced glycation end-product receptor activity")
Jens a(CHEBI:"glutamate(1-)") a(GO:"excitatory synapse") complex(GO:"NF-kappaB complex")
Jens a(MESH:Morphine) p(FPLX:IKB) p(FPLX:NFkappaB)
Jens a(CHEBI:nicotine) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") bp(GO:"ERK1 and ERK2 cascade")
Jens p(MGI:Mapt) p(MGI:Mapt, var("p.Ala152Thr")) p(MGI:Mapt, var("p.Ala152Thr"))
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Supranuclear Palsy, Progressive")
Jens a(CHEBI:"amyloid-beta") p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") path(HBP:neurotoxicity)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(CHEBI:"amyloid-beta") bp(GO:"lysosomal protein catabolic process") bp(GO:memory)
Jens g(HBP:"APOE e4") p(HGNC:APP) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"calcium(2+)") a(MESH:"Receptors, Nicotinic") p(HGNC:CHRNA7)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Alzheimer Disease")
Jens a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") bp(GO:learning) p(MGI:App, frag("25_35"))
Jens bp(GO:"neuron death") p(HGNC:MMP2) path(MESH:"Alzheimer Disease")
Jens p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") p(MGI:"oncostatin M") path(MESH:Glioblastoma)
Jens a(CHEBI:"amyloid-beta") complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") path(MESH:"Pick Disease of the Brain")
Jens a(CHEBI:"amyloid-beta") a(MESH:Microglia) bp(GO:phagocytosis)
Jens bp(GO:"neuron death") p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") path(MESH:"Alzheimer Disease")
Jens bp(GO:"long-term synaptic potentiation") p(HGNC:HSPB1) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") p(HGNC:CHRM1) p(HGNC:MAPT, pmod(Ph))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:CHRNA4)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:resveratrol) bp(GO:"autophagosome assembly")
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:CDK5) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") p(HGNC:SYK)
Jens a(CHEBI:"amyloid-beta") p(HGNC:APP) p(HGNC:DKK1)
Jens a(HBP:"amyloid-beta oligomers") p(HGNC:MAPT, pmod(Ph, Ser, 356)) p(INTERPRO:"Kinase associated domain 1 (KA1)")
Jens a(CHEBI:"potassium(1+)") complex(GO:"NLRP1 inflammasome complex") p(HGNC:IL1B)
Jens p(HGNC:CHRNA7) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") p(HGNC:BAG1) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:nicotine) bp(GO:"MAPK cascade") p(FPLX:NFkappaB)
Jens a(HBP:"Tau aggregates") bp(MESH:Autophagy) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) bp(GO:"synaptic transmission, cholinergic")
Jens bp(GO:mitophagy) p(HGNC:PRKN) p(HGNC:PRKN, var("?"))
Jens complex(GO:"NF-kappaB complex") p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:ambroxol) bp(GO:macroautophagy) p(HGNC:SNCA)
Jens bp(GO:macroautophagy) p(HGNC:TFEB) path(MESH:"Plaque, Amyloid")
Jens bp(GO:"chaperone-mediated autophagy") p(MGI:Mapt) p(MGI:Mapt, var("p.Pro301Leu"))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:Temsirolimus) bp(GO:macroautophagy)
Jens p(HGNC:AK1) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:APOE) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"methylene blue") bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph))
Jens bp(GO:cognition) p(HGNC:MAPT, pmod(Ph)) p(HGNC:MAPT, var("p.Lys280del"))
Jens bp(GO:locomotion) p(HGNC:MAPT) p(HGNC:MAPT, var("p.Lys280del"))
Jens a(CHEBI:"amyloid-beta polypeptide 42") bp(GO:endocytosis) g(HBP:"APOE e4")
Jens a(CHEBI:chloroquine) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:acrolein) a(GO:"neurofibrillary tangle") path(MESH:"Alzheimer Disease")
Jens complex(GO:"NF-kappaB complex") p(HGNC:SIRT1) path(MESH:"Alzheimer Disease")
Jens bp(GO:"MAPK cascade") p(FPLX:NFkappaB) p(HGNC:TNF)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) bp(GO:"apoptotic process")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens bp(GO:"microglial cell activation") p(HGNC:IL18) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease") path(MESH:"Diabetes Mellitus")
Jens a(GO:"neurofibrillary tangle") p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:DKK1) p(HGNC:WNT3A)
Jens a(CHEBI:resveratrol) p(HGNC:MID1) p(HGNC:PPP2CA)
Jens a(CHEBI:acetylcholine) bp(GO:"synaptic transmission, cholinergic") p(HGNC:ACHE)
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Ser, 404)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) a(MESH:"Cholinesterase Inhibitors")
Jens complex(GO:"NF-kappaB complex") p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
Jens bp(GO:"chaperone-mediated autophagy") p(MGI:Mapt, var("p.Pro301Leu")) path(MESH:"Proteostasis Deficiencies")
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:GSK3B) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens bp(GO:autophagy) p(HGNC:HSPB1) p(HGNC:MAPT, pmod(Ph))
Jens p(HGNC:CDC37) p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Thr, 231))
Jens a(CHEBI:"amyloid-beta") complex(GO:"NLRP1 inflammasome complex") p(HGNC:IL18)
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:SYK)
Jens a(CHEBI:"amyloid-beta") p(MESH:Neprilysin) path(MESH:"Alzheimer Disease")
Jens a(GO:"neurofibrillary tangle") a(HBP:"Tau aggregates") path(MESH:"Alzheimer Disease")
Jens p(HGNC:AK1) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens bp(GO:"neuron death") complex(GO:"NF-kappaB complex") p(HGNC:TNF)
Jens a(CHEBI:rolipram) a(HBP:"Tau aggregates") p(HGNC:MAPT)
Jens bp(GO:"neuron death") complex(GO:"NF-kappaB complex") p(HGNC:CXCL8)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:APOE)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:AQP4)
Jens a(CHEBI:"D-ribose") a(HBP:"advanced glycation end product") p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jens a(CHEBI:"amyloid-beta") p(HGNC:BIN1) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:SYK)
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Thr, 205)) path(MESH:"Alzheimer Disease")
Jens a(GO:"late endosome") p(MGI:Mapt) p(MGI:Mapt, var("p.Pro301Leu"))
Jens a(MESH:Neurons) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:MAPT, pmod(Ph)) p(HGNC:TREM2)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:ABCB1)
Jens a(CHEBI:"amyloid-beta") bp(GO:"neuron death") p(HGNC:RAB5A)
Jens a(CHEBI:cholesterol) bp(GO:endocytosis) p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
Jens a(CHEBI:"amyloid-beta") p(HGNC:BACE1) p(HGNC:TNF)
Jens p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:OTUB1)
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:CDK5) path(MESH:"Alzheimer Disease")
Jens bp(GO:autophagy) p(HGNC:SQSTM1) p(MESH:Proteins, pmod(HBP:misfolding))
Jens a(CHEBI:galanthamine) p(HGNC:HMOX1) path(MESH:"Alzheimer Disease")
Jens a(HBP:HBP00093) bp(GO:autophagy) p(HGNC:HDAC6)
Jens a(CHEBI:dopamine) a(CHEBI:nicotine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(HBP:HBP00074) path(MESH:"Alzheimer Disease") path(MESH:"Cognitive Dysfunction")
Jens a(CHEBI:"amyloid-beta") bp(GO:"inflammatory response") p(HGNC:DKK1)
Jens a(CHEBI:"amyloid-beta") bp(GO:"neuron death") path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens bp(GO:"MAPK cascade") p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Jens bp(MESH:Autophagy) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"alpha,alpha-trehalose") a(HBP:"Tau aggregates") bp(GO:macroautophagy)
Jens p(HGNC:IL18) path(MESH:"Alzheimer Disease") path(MESH:Dementia)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:IDE)
Jens a(CHEBI:"amyloid-beta") p(HGNC:APP) p(HGNC:BACE1)
Jens a(MESH:"Amyloid beta-Peptides") complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")
Jens bp(GO:locomotion) composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDC37) p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 202))
Jens a(PUBCHEM:71361092) p(FPLX:PPP2) path(MESH:Neoplasms)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) p(FPLX:CHRN)
Jens a(CHEBI:heparin) a(HBP:"Tau aggregates") p(HGNC:MAPT, var("?"))
Jens p(HGNC:CDK2) p(HGNC:MAPT, pmod(Ph, Ser, 199)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") a(HBP:"Tau aggregates")
Jens a(CHEBI:"amyloid-beta") bp(GO:"lysosomal protein catabolic process") bp(GO:autophagy)
Jens p(HGNC:CHRNA7) p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, var("p.Arg406Trp"))
Jens a(CHEBI:epoxomicin) p(FPLX:Proteasome) p(HGNC:MAPT)
Jens a(CHEBI:Calpeptin) p(HGNC:CAPN2) p(HGNC:HTT, var("?"))
Jens a(CHEBI:memantine) bp(GO:cognition) path(MESH:"Alzheimer Disease")
Jens bp(GO:cognition) p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Jens p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) path(MESH:"Alcohol Drinking") r(HGNC:ADNP)
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) p(HGNC:BCHE)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 174)) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") bp(GO:"lysosomal microautophagy") path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(NGlyco)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"calcium(2+)") a(CHEBI:"glutamate(2-)") bp(HBP:Excitotoxicity)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:rosiglitazone) a(HBP:HBP00018)
Jens a(CHEBI:"amyloid-beta") a(GO:lysosome) bp(GO:endocytosis)
Jens bp(GO:"MAPK cascade") p(HGNC:AGER) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") bp(GO:cognition) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(MESH:"Neuronal Outgrowth") p(HGNC:APP)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) path(MESH:"Plaque, Amyloid")
Jens bp(GO:macroautophagy) p(MGI:Mapt, var("p.Ala152Thr")) p(MGI:Mapt, var("p.Ala152Thr"))
Jens p(HGNC:CHAT) path(MESH:"Alzheimer Disease") path(MESH:Dementia)
Jens a(CHEBI:"amyloid-beta") p(HGNC:TFEB) path(MESH:"Plaque, Amyloid")
Jens p(HGNC:MAPT, pmod(Ph)) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:macroautophagy) p(HGNC:TFEB)
Jens complex(p(HGNC:FYN), p(HGNC:MAPT)) p(HGNC:FYN) path(MESH:"Alzheimer Disease")
Jens a(MESH:Proteins) a(MESH:Proteins) p(HGNC:RAB5A)
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:TNF)
Jens p(HBP:"cis p-tau") p(HBP:"cis p-tau") p(HGNC:PIN1)
Jens a(CHEBI:"calcium(2+)") a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7)
Jens a(PUBCHEM:442534) bp(GO:memory) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta polypeptide 42") bp(MESH:Neuroprotection) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(CHEBI:"amyloid-beta") p(HGNC:RELA) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) a(CHEBI:acetylcholine)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") bp(GO:endocytosis)
Jens p(HGNC:MAPK1) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) p(HGNC:CHRNA7)
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, pmod(HBP:glycation))
Jens a(CHEBI:"amyloid-beta") p(HGNC:NFKB1) path(MESH:Anxiety)
Jens a(CHEBI:"amyloid-beta") p(HGNC:CHRNA4) path(MESH:"Alzheimer Disease")
Jens a(HBP:"amyloid-beta oligomers") p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") complex(GO:"NLRP3 inflammasome complex") p(HGNC:IL1B)
Jens a(CHEBI:galanthamine) bp(GO:cognition) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(OGlyco)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"potassium(1+)") complex(GO:"NLRP3 inflammasome complex") p(HGNC:IL1B)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") p(HGNC:BACE1)
Jens complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) p(HGNC:HSPB1) p(HGNC:MAPT, pmod(Ph))
Jens p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub))
Jens p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:donepezil) bp(GO:cognition) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, var("?"))
Jens a(GO:"neurofibrillary tangle") a(HBP:"Tau fibrils") p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
Jens a(CHEBI:"amyloid-beta") p(HGNC:MAPT, pmod(Ph)) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(CHEBI:curcumin) bp(GO:macroautophagy) p(FPLX:mTORC1)
Jens a(CHEBI:acetylcholine) a(CHEBI:nicotine) p(HGNC:CHRNA7)
Jens a(CHEBI:"alpha,alpha-trehalose") a(CHEBI:"amyloid-beta") bp(GO:autophagy)
Jens a(HBP:"Tau oligomers") bp(GO:"long-term synaptic potentiation") p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(GO:lysosome) p(HGNC:TFEB)
Jens a(CHEBI:"amyloid-beta") bp(GO:"long-term synaptic potentiation") p(HGNC:FYN)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) a(CHEBI:nicotine)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:rosiglitazone) p(HGNC:PPARG)
Jens a(HBP:HBP00089) bp(GO:"microglial cell activation") p(HGNC:IL1B)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:rosiglitazone) a(MESH:Microglia)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT) path(HBP:Neurodegeneration)
Jens p(FPLX:NFkappaB) p(FPLX:NFkappaB) p(HGNC:IL1B)
Jens a(HBP:"Tau aggregates") bp(MESH:Autophagy) p(HBP:"Tau C3")
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ph, Ser, 262)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:"cell death") p(HGNC:CHRM1)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) bp(GO:memory)
Jens a(CHEBI:"amyloid-beta") a(GO:lysosome) complex(GO:"NLRP3 inflammasome complex")
Jens p(HGNC:MAPT) p(HGNC:MAPT) path(MESH:"Frontotemporal Dementia")
Jens p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:TGM2)
Jens complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens p(FPLX:ERK) p(HGNC:MAPT, pmod(Ph, Ser, 199)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:HSPB1) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(HP:"glymphatic system") p(HGNC:MAPT) path(MESH:"Brain Injuries, Traumatic")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") a(CHEBI:nicotine)
Jens a(HBP:"granulovacuolar degeneration") p(HGNC:MAPT, pmod(Ph, Ser, 262)) p(HGNC:MARK4, pmod(Ph))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") bp(GO:phagocytosis)
Jens complex(p(HGNC:FYN), p(HGNC:MAPT)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Corticobasal Degeneration") p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jens a(CHEBI:"amyloid-beta") p(HGNC:MAPT, pmod(Ph)) path(HBP:Neurodegeneration)
Jens bp(MESH:Neuroprotection) p(HGNC:CHRNA7) p(HGNC:JAK2)
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") bp(MESH:Autophagy)
Jens bp(GO:cognition) p(HGNC:FYN) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"reactive oxygen species") bp(GO:"inflammatory response") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:donepezil) p(HGNC:BCL2)
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:BACE1)
Jens p(FPLX:ERK) p(HGNC:MAPT, pmod(Ph, Ser, 404)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"lithium atom") bp(GO:autophagy) p(HGNC:MAPT)
Jens p(HGNC:MAPT, pmod(Ph)) p(HGNC:PPP5C) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") a(MESH:Trehalose) bp(MESH:Autophagy)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(MESH:Liver)
Jens p(HGNC:MAPT, pmod(Ph, Ser, 202)) p(HGNC:MAPT, var("p.Pro301Ser")) p(HGNC:MAPT, var("p.Pro301Ser"))
Jens bp(GO:"microtubule polymerization") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:nicotine) p(FPLX:PI3K) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(HBP:"Tau aggregates") path(MESH:"Alzheimer Disease") path(MESH:"Neurofibrillary Tangles")
Jens a(MESH:Lysosomes) bp(MESH:Proteolysis) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:IL1B) p(HGNC:NFKB1)
Jens a(CHEBI:"amyloid-beta") bp(GO:aging) p(HGNC:IL18)
Jens a(GO:"neurofibrillary tangle") p(ECCODE:"2.3.2.13") path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPK1) p(HGNC:MAPT, pmod(Ph, Thr, 205)) path(MESH:"Alzheimer Disease")
Jens bp(GO:autophagy) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:galanthamine) bp(GO:learning) p(MGI:App, frag("25_35"))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") bp(GO:aging)
Jens a(CHEBI:"amyloid-beta") bp(GO:"lysosomal protein catabolic process") p(HGNC:PSEN1, var("?"))
Jens p(HBP:"N-terminal fragment of ATF6") p(HBP:"N-terminal fragment of ATF6") p(HBP:"N-terminal fragment of ATF6")
Jens a(CHEBI:"amyloid-beta") p(HGNC:CASP1) p(HGNC:IL1B)
Jens p(FPLX:PPP2) p(HGNC:CDK5) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:donepezil) p(HGNC:LRP1) path(MESH:"Alzheimer Disease")
Jens bp(GO:"neuron death") p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:nicotine) bp(GO:cognition) p(HGNC:CHRNA7)
Jens a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) p(FPLX:CHRN)
Jens a(HBP:"Tau aggregates") complex(GO:"proteasome complex") path(HBP:Neurodegeneration)
Jens p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:SQSTM1)
Jens bp(GO:autophagy) bp(MESH:Aging) p(FPLX:HSP90)
Jens p(HGNC:MAPT, var("p.Pro301Ser")) p(HGNC:MAPT, var("p.Pro301Ser")) p(HGNC:MAPT, var("p.Pro301Ser"))
Jens a(MESH:antalarmin) path(HBP:"isolation rearing") r(RGD:Ntrk2)
Jens p(FPLX:HSP90) p(HGNC:MAPT, pmod(Ph)) p(HGNC:PTGES3)
Jens a(CHEBI:"lithium(1+)") bp(GO:autophagy) p(HGNC:MAPT)
Jens a(CHEBI:galanthamine) bp(MESH:Neuroprotection) p(HGNC:CHRNA7)
Jens a(CHEBI:Calpeptin) bp(GO:autophagy) p(HGNC:CAPN2)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ph, Tyr)) p(HGNC:SYK)
Jens a(CHEBI:"amyloid-beta") bp(GO:autophagy) path(HBP:neurotoxicity)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 290)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:simvastatin) bp(GO:"ERK1 and ERK2 cascade") bp(GO:"apoptotic process")
Jens complex(GO:"inflammasome complex") p(HGNC:CASP1) p(HGNC:IL1B)
Jens bp(GO:aging) p(HGNC:IL18) path(MESH:"Alzheimer Disease")
Jens bp(GO:"neuron death") p(HGNC:RAB5A) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:donepezil) p(HGNC:ACHE)
Jens p(HGNC:CTSD) p(HGNC:MAPT) path(MESH:"Frontotemporal Dementia")
Jens p(FPLX:GSK3) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"D-ribose") a(CHEBI:"advanced glycation end-product") p(MGI:Mapt, pmod(Ph, Ser, 396))
Jens p(HGNC:MAPT, pmod(Ph, Ser, 202)) p(HGNC:MAPT, var("p.Glu391*")) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Niemann-Pick Diseases")
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, var("p.Pro301Leu"))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") complex(GO:"NLRP1 inflammasome complex")
Jens a(CHEBI:sirolimus) bp(GO:macroautophagy) p(FPLX:mTORC1)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:Nilvadipine) p(HGNC:BACE1)
Jens a(CHEBI:"amyloid-beta") a(PUBCHEM:16057918) p(HGNC:BCL2L1)
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Frontotemporal Dementia")
Jens a(CHEBI:sirolimus) bp(GO:autophagy) p(FPLX:mTORC1)
Jens a(MESH:"Cholinergic Neurons") bp(GO:memory) complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta") p(HGNC:ADAM10) p(HGNC:APP)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine)
Jens a(CHEBI:"amyloid-beta") p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"Hsp90 inhibitor") a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) p(HGNC:ACHE)
Jens a(MESH:"Cholinergic Neurons") path(MESH:"Alzheimer Disease") path(MESH:Depression)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:Nilvadipine) p(HGNC:MAPT, pmod(Ph, Ser, 202))
Jens bp(MESH:"Oxidative Stress") complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")
Jens p(HGNC:CAPN2) p(HGNC:CAST) p(HGNC:HTT, var("?"))
Jens a(HBP:"amyloid-beta oligomers") p(HGNC:MAPT, pmod(Ph, Ser, 262)) p(INTERPRO:"Kinase associated domain 1 (KA1)")
Jens p(HGNC:FKBP5) p(HGNC:MAPT, pmod(Ph, Ser, 199)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, frag("?")) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:acetylcholine) a(CHEBI:galanthamine) p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:water) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") complex(GO:"inflammasome complex") p(HGNC:IL1B)
Jens m(MIRBASE:"hsa-mir-155") p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ph, Thr, 231)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:galanthamine) p(HGNC:ACHE) path(MESH:"Alzheimer Disease")
Jens p(MGI:"interleukin 1 alpha") p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") p(MGI:"oncostatin M")
Jens complex(GO:"proteasome complex") p(FPLX:PKA) p(FPLX:PKA, pmod(Ub))
Jens complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT) p(HGNC:MAPT, var("p.Lys280del"))
Jens a(GO:"neurofibrillary tangle") a(HBP:"Tau aggregates") p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT) path(MESH:"Brain Injuries, Traumatic")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(FPLX:TLR)
Jens a(CHEBI:"amyloid-beta") a(HBP:HBP00018) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"calcium(2+)") a(CHEBI:dopamine) a(CHEBI:nicotine)
Jens a(CHEBI:palbociclib) a(HBP:"Tau isoform F (441 aa)") p(HGNC:CDK4)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ac, Lys, 321)) path(MESH:"Alzheimer Disease")
Jens p(FPLX:ERK) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens complex(GO:"NF-kappaB complex") p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(FPLX:ERK) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub)) p(HGNC:OTUB1)
Jens a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) a(MESH:"Receptors, Nicotinic")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ac, Lys, 259)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:galanthamine) bp(GO:cognition) p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta polypeptide 42") complex(GO:"NF-kappaB complex") p(HGNC:BACE1)
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") p(HGNC:MAPT)
Jens p(HGNC:MAPT, pmod(Ph)) p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
Jens p(HBP:"4R tau") p(HGNC:MAPT, var("p.Gly272Val")) path(MESH:"Frontotemporal Dementia")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:pioglitazone) p(HGNC:PPARG)
Jens a(CHEBI:nicotine) a(MESH:"SNARE Proteins") p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta") p(FPLX:NFkappaB) p(HGNC:BACE1)
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ph)) path(HBP:Neurodegeneration)
Jens a(CHEBI:dextran) a(CHEBI:dextran) a(CHEBI:dextran)
Jens a(CHEBI:"calcium(2+)") bp(MESH:"Oxidative Stress") p(HGNC:S100B)
Jens a(MESH:Microglia) complex(GO:"NF-kappaB complex") p(HGNC:IL6)
Jens a(CHEBI:rolipram) complex(GO:"proteasome complex") p(FPLX:PKA)
Jens a(HBP:"Tau aggregates") complex(GO:"proteasome complex") p(HGNC:MAPT, pmod(Ph))
Jens a(GO:"neurofibrillary tangle") p(HGNC:CDKN2A) path(MESH:"Alzheimer Disease")
Jens a(GO:microtubule) p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") bp(GO:"long-term synaptic potentiation")
Jens bp(GO:"long-term synaptic potentiation") p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Thr, 205))
Jens a(HBP:"Tau oligomers") p(HGNC:AHSA1) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") a(HBP:"Tau oligomers") bp(MESH:Autophagy)
Jens a(CHEBI:"amyloid-beta") p(HGNC:ACE) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(MESH:"Lymphatic Vessels") bp(GO:memory)
Jens p(HGNC:FYN) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:ANP32A) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(HGNC:MAPK14) p(HGNC:RELA)
Jens p(HGNC:HDAC6) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:Anatabine) path(MESH:"Interpersonal Relations")
Jens bp(GO:"MAPK cascade") p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Thr, 231)) path(MESH:"Alzheimer Disease")
Jens bp(GO:cognition) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT) p(HGNC:NPEPPS) path(MESH:"Frontotemporal Dementia")
Jens a(CHEBI:galanthamine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") path(MESH:"Alzheimer Disease")
Jens bp(GO:"neuron death") p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens g(HGNC:APOE) p(HGNC:APOE) path(MESH:"Alzheimer Disease")
Jens p(HGNC:CHRNA7) p(HGNC:CHRNA7) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ac, Lys, 174)) p(HGNC:MAPT, pmod(Ph, Thr, 205))
Jens p(HGNC:HSF1) p(HGNC:HSF1) p(HGNC:HSF1)
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(CHEBI:"amyloid-beta") a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") a(MESH:Microglia)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") bp(GO:endocytosis)
Jens p(HGNC:HSPB1) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"reactive oxygen species") p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(MESH:Microglia) bp(GO:"peroxisome proliferator activated receptor signaling pathway")
Jens a(CHEBI:"amyloid-beta") bp(GO:memory) g(HGNC:NLRP3)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:donepezil) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens bp(GO:"neuron death") p(HGNC:MAPT, pmod(Ph)) p(HGNC:MAPT, var("p.Ala152Thr"))
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT) path(HBP:Neurodegeneration)
Jens a(HBP:"Tau epitope, PHF1") p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jens a(CHEBI:chloroquine) bp(GO:autophagy) p(HGNC:MAPT)
Jens a(CHEBI:"alpha-tocopherol") a(CHEBI:"amyloid-beta") bp(GO:memory)
Jens a(HBP:"Tau epitope, PHF1") p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:nicotine) a(HBP:"Tau aggregates") path(HBP:neurotoxicity)
Jens a(HBP:"protein aggregates") bp(GO:autophagy) path(MESH:"Amyotrophic Lateral Sclerosis")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
Jens a(CHEBI:"lithium(1+)") bp(GO:autophagy) p(HGNC:SNCA)
Jens p(FPLX:HSP90) p(HGNC:MAPT, pmod(Ph)) p(HGNC:STUB1)
Jens a(CHEBI:galanthamine) bp(GO:learning) path(MESH:"Alzheimer Disease")
Jens p(HGNC:BACE1) p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"okadaic acid") p(HGNC:MAPT, pmod(Ph, Ser, 202)) p(HGNC:MAPT, pmod(Sumo, Lys, 340))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jens p(HGNC:MAPT, pmod(OGlyco)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(HBP:HBP00074) bp(GO:aging) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") bp(GO:phagocytosis)
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") complex(GO:"calcium- and calmodulin-dependent protein kinase complex")
Jens a(GO:"neurofibrillary tangle") complex(GO:"NF-kappaB complex") p(HGNC:TNF)
Jens p(FPLX:ERK) p(FPLX:NFkappaB) p(HGNC:TNF)
Jens complex(GO:"proteasome complex") p(HGNC:PRKN) p(HGNC:SNCA)
Jens a(GO:"neurofibrillary tangle") p(HGNC:TGM2) path(MESH:"Alzheimer Disease")
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT, var("p.Gly272Val"))
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") bp(GO:aging)
Jens bp(MESH:Aging) p(HGNC:PTGES3) path(MESH:"Protein Aggregation, Pathological")
Jens a(CHEBI:"amyloid-beta") a(MESH:Microglia) p(HGNC:TREM2, var("p.Arg47His"))
Jens complex(GO:"protein phosphatase type 2A complex") p(FPLX:PPP2, pmod(Ph, Tyr, 307)) p(HGNC:PTPA)
Jens a(CHEBI:"reactive oxygen species") complex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")
Jens bp(GO:"microglial cell activation") p(HGNC:NR1H3) path(MESH:"Alzheimer Disease")
Jens bp(GO:"microglial cell activation") p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:nicotine) bp(GO:"ERK1 and ERK2 cascade") p(FPLX:NFkappaB)
Jens a(MESH:"Amyloid beta-Peptides") p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") p(FPLX:CHRN) path(MESH:"Alzheimer Disease")
Jens p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) p(FPLX:CHRM)
Jens a(MESH:Proteins) a(MESH:Proteins) bp(GO:endocytosis)
Jens a(CHEBI:acetylcholine) bp(GO:"membrane depolarization") p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens p(HGNC:MAPT, pmod(Ph, Thr, 205)) p(HGNC:MAPT, var("p.Pro301Ser")) p(HGNC:MAPT, var("p.Pro301Ser"))
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ac, Lys, 174)) path(MESH:"Alzheimer Disease")
Jens bp(GO:"microtubule polymerization") p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") bp(GO:"canonical Wnt signaling pathway") composite(p(HGNC:APP), p(HGNC:VANGL2))
Jens a(HBP:"amyloid-beta aggregates") p(HGNC:APP, var("?")) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") bp(GO:"apoptotic process")
Jens a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT) p(HGNC:MAPT)
Jens complex(GO:"proteasome complex") p(HGNC:MAPT, pmod(Ph)) path(HBP:Neurodegeneration)
Jens a(CHEBI:epoxomicin) p(HGNC:MAPT) p(HGNC:MAPT)
Jens p(HGNC:MAPT) p(HGNC:TGM2) path(MESH:"Alzheimer Disease")
Jens bp(GO:"MAPK cascade") p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
Jens p(FPLX:NFkappaB) p(FPLX:NFkappaB) p(FPLX:NFkappaB)
Jens a(CHEBI:"amyloid-beta") a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") bp(GO:memory)
Jens a(HBP:"alpha-synuclein aggregates") p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") p(HGNC:MAPT, pmod(Ac, Lys, 353)) path(MESH:"Alzheimer Disease")
Jens a(HBP:HBP00074) path(MESH:"Alzheimer Disease") path(MESH:Dementia)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 259)) p(HGNC:MAPT, pmod(Ac, Lys, 259)) p(HGNC:MAPT, pmod(Ac, Lys, 259))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:rivastigmine) p(HGNC:ACHE)
Jens a(HBP:"Tau aggregates") a(MESH:Autophagosomes) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") p(FPLX:TLR) p(HGNC:IL1B)
Jens complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))
Jens g(HBP:"APOE e4") p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") p(HGNC:APP)
Jens a(HBP:"sonicated tau fibrils") a(HBP:"sonicated tau fibrils") a(HBP:"sonicated tau fibrils")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Frontotemporal Dementia")
Jens a(CHEBI:"methylene blue") bp(MESH:Autophagy) p(HGNC:MAPT)
Jens p(MGI:"interleukin 1 alpha") p(MGI:"oncostatin M") p(MGI:"signal transducer and activator of transcription 3")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) p(FPLX:CHRN)
Jens a(HBP:"Tau aggregates") p(HGNCGENEFAMILY:Caspases) path(MESH:"Neurofibrillary Tangles")
Jens bp(GO:endocytosis) g(HBP:"APOE e4") p(HGNC:APP)
Jens a(CHEBI:nicotine) a(HBP:"alpha-4 beta-2 nAChR") a(MESH:"Dopaminergic Neurons")
Jens a(HBP:"Tau epitope, PHF1") bp(MESH:Autophagy) p(HGNC:MAPT)
Jens a(HBP:"Tau aggregates") bp(MESH:Autophagy) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") bp(GO:"long-term synaptic potentiation") p(HGNC:NFKB1)
Jens a(CHEBI:lactacystin) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:rolipram) a(HBP:"Tau aggregates") complex(GO:"proteasome complex")
Jens a(CHEBI:acrolein) path(MESH:"Alzheimer Disease") path(MESH:"Plaque, Amyloid")
Jens p(HBP:HBP00065) path(MESH:"Alzheimer Disease") path(MESH:"Plaque, Amyloid")
Jens a(CHEBI:"amyloid-beta") bp(GO:endocytosis) p(HGNC:APP)
Jens a(CHEBI:"glutamate(2-)") p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Jens bp(MESH:Aging) p(FPLX:HSPA) path(MESH:"Protein Aggregation, Pathological")
Jens a(CHEBI:Calpeptin) bp(GO:autophagy) p(HGNC:CAPN1)
Jens bp(GO:autophagy) complex(GO:"proteasome complex") p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(GO:synapse) bp(GO:endocytosis)
Jens a(CHEBI:nicotine) p(HGNC:CHRNA7) p(HGNC:JAK2)
Jens a(CHEBI:nicotine) a(MESH:"Dopaminergic Neurons") p(FPLX:CHRN)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:simvastatin) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau epitope, PHF1") p(HGNC:GSK3B) p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jens a(CHEBI:"amyloid-beta") bp(GO:memory) p(HGNC:BACE1)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:donepezil) p(HGNC:CHRNA4)
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") p(HBP:"Tau epitope, AT8") p(MGI:Crhr1)
Jens a(CHEBI:"amyloid-beta") p(HBP:"Tau aggregates") p(HGNC:MAPT)
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:GSK3B) p(HGNC:MAPT, pmod(Ph))
Jens p(HGNC:IL1B) p(HGNC:PYCARD) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"alpha,alpha-trehalose") bp(GO:autophagy) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") complex(GO:"NLRP1 inflammasome complex") p(HGNC:IL1B)
Jens p(HBP:HBP00053, var("p.Lys280del")) p(HBP:HBP00053, var("p.Lys280del")) p(HBP:HBP00053, var("p.Lys280del"))
Jens a(CHEBI:"reactive oxygen species") p(FPLX:ERK) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:nicotine) bp(GO:"MAPK cascade") p(HBP:"alpha-4 beta-2 nAChR")
Jens a(HBP:HBP00006) p(HBP:HBP00053, var("p.Lys280del")) p(HBP:HBP00053, var("p.Lys280delinsProPro"))
Jens a(CHEBI:donepezil) p(HGNC:ABCB1) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:acetylcholine) bp(GO:"synaptic transmission, cholinergic") bp(GO:memory)
Jens p(HBP:"UBB+1", pmod(UbPoly)) p(HBP:"UBB+1", pmod(UbPoly)) p(HBP:"UBB+1", pmod(UbPoly))
Jens a(CHEBI:"D-ribose") a(HBP:"advanced glycation end product") p(HGNC:MAPT, pmod(Ph, Ser, 214))
Jens a(CHEBI:acetylcholine) bp(GO:"membrane depolarization") p(FPLX:CHRN)
Jens a(CHEBI:rolipram) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") complex(p(HGNC:APP), p(HGNC:LRP1)) p(HGNC:APP)
Jens p(HBP:"4R tau") p(HGNC:SRSF2) path(MESH:"Supranuclear Palsy, Progressive")
Jens a(CHEBI:Thrombin) a(HBP:"Tau aggregates") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) a(CHEBI:acetylcholine)
Jens a(CHEBI:galanthamine) p(FPLX:CHRN) path(MESH:"Alzheimer Disease")
Jens bp(GO:"protein folding") bp(MESH:Aging) p(FPLX:HSP90)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) bp(GO:"MAPK cascade")
Jens a(HBP:"Corticobasal Degeneration") a(HBP:"Tau oligomers") p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") bp(GO:autophagy) p(HGNC:IL1B)
Jens a(CHEBI:"amyloid-beta") a(HBP:HBP00038) bp(GO:phagocytosis)
Jens a(CHEBI:"amyloid-beta polypeptide 42") bp(GO:phagocytosis) p(HGNC:TREM2)
Jens a(CHEBI:"amyloid-beta") bp(GO:endocytosis) p(HGNC:BIN1)
Jens a(HBP:"Tau oligomers") a(HBP:"Tau oligomers") path(MESH:Tauopathies)
Jens a(GO:autolysosome) bp(GO:"lysosomal protein catabolic process") path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDK2) p(HGNC:MAPT, pmod(Ph, Ser, 396)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:"apoptotic process") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") complex(a(GO:"membrane attack complex"), p(HGNC:C5))
Jens m(HGNC:MIR125B1) p(HGNC:CDKN2A) path(MESH:"Alzheimer Disease")
Jens bp(MESH:Aging) p(FPLX:HSP90) p(HGNC:PTGES3)
Jens p(HGNC:MAPT) p(HGNC:MAPT) path(MESH:"Pick Disease of the Brain")
Jens bp(GO:macroautophagy) p(FPLX:AMPK) p(FPLX:mTORC1)
Jens p(FPLX:GSK3) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens a(PUBCHEM:377503130) p(FPLX:"CCT_complex") p(HGNC:HSF1)
Jens bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") p(HGNC:BAG1) p(HGNC:MAPT)
Jens bp(GO:autophagy) p(FPLX:HSP90) p(HGNC:MAPT, pmod(Ph))
Jens p(HGNC:IL18) p(HGNC:PYCARD) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau oligomers") bp(GO:"mitochondrion organization") bp(HP:Neurodegeneration)
Jens bp(GO:"neuron death") complex(GO:"NF-kappaB complex") p(HGNC:IL1B)
Jens a(CHEBI:"calcium(2+)") a(CHEBI:"calcium(2+)") complex(p(HGNC:MAPT), p(HGNC:TGM2))
Jens a(CHEBI:"amyloid-beta") bp(GO:"apoptotic process") p(HGNC:BCL2)
Jens a(CHEBI:"amyloid-beta") bp(GO:memory) path(MESH:"Alzheimer Disease")
Jens p(FPLX:PPP2) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:endocytosis) bp(GO:memory)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) bp(MESH:Neuroprotection)
Jens a(HBP:"Tau isoform F (441 aa)") a(HBP:"Tau isoform F (441 aa)") path(MESH:"Protein Aggregation, Pathological")
Jens a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))
Jens a(CHEBI:"amyloid-beta") p(HGNC:BACE1) p(HGNC:RELA)
Jens bp(GO:"neuron death") p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens p(MGI:Mapt) p(MGI:Mapt, var("p.Pro301Leu")) p(MGI:Mapt, var("p.Pro301Leu"))
Jens p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
Jens bp(MESH:"Oxidative Stress") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"calcium(2+)") a(CHEBI:nicotine) p(HGNC:CHRNA7)
Jens p(MESH:Proteins, pmod(Ub)) p(MESH:Proteins, pmod(Ub)) p(MESH:Proteins, pmod(Ub))
Jens a(CHEBI:"calcium(2+)") a(CHEBI:nicotine) p(HBP:"alpha-4 beta-2 nAChR")
Jens a(HBP:"Tau aggregates") p(HGNC:AHSA1) path(MESH:"Alzheimer Disease")
Jens bp(GO:autophagy) p(HGNC:CAPN1) p(HGNC:CAST)
Jens a(CHEBI:wortmannin) bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph, Ser, 262))
Jens bp(GO:autophagy) p(FPLX:AMPK) p(FPLX:mTORC1)
Jens a(CHEBI:nicotine) bp(GO:cognition) p(HBP:"alpha-4 beta-2 nAChR")
Jens complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) p(HGNC:PRKN, var("p.Arg42")) path(MESH:"Parkinsonian Disorders")
Jens a(CHEBI:Thrombin) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens bp(MESH:Aging) p(HGNC:AHSA1) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT, var("p.Ala152Thr")) path(MESH:"Supranuclear Palsy, Progressive")
Jens bp(GO:aging) p(HGNC:MAPT) p(HGNC:SYK)
Jens a(CHEBI:"proteasome inhibitor") bp(GO:autophagy) p(HGNC:MAPT)
Jens a(HBP:HBP00074) p(HGNC:NGFR) path(MESH:"Cognitive Dysfunction")
Jens a(CHEBI:"amyloid-beta") bp(GO:"MAPK cascade") p(HGNC:TNF)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNC:TNF)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:ACE)
Jens a(CHEBI:"amyloid-beta") bp(GO:"lysosomal protein catabolic process") path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") complex(GO:"proteasome complex")
Jens a(CHEBI:"amyloid-beta") bp(GO:aging) bp(GO:locomotion)
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jens bp(GO:endocytosis) g(HBP:"APOE e4") p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
Jens p(HGNC:NGFR) path(MESH:"Alzheimer Disease") path(MESH:"Cognitive Dysfunction")
Jens a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Jens a(GO:"late endosome") p(MGI:Mapt) p(MGI:Mapt, var("p.Ala152Thr"))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:rosiglitazone) bp(GO:"learning or memory")
Jens a(CHEBI:sirolimus) bp(GO:autophagy) p(HGNC:SNCA)
Jens a(CHEBI:"amyloid-beta polypeptide 42") complex(GO:"NF-kappaB complex") path(HBP:neurotoxicity)
Jens complex(GO:"NF-kappaB complex") p(HGNC:IL6) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNC:BCL2L1)
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 404)) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ph)) p(HGNC:MAPT, pmod(Ub)) path(MESH:"Alzheimer Disease")
Jens a(HBP:HBP00018) path(MESH:"Alzheimer Disease") path(MESH:"Plaque, Amyloid")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:sirolimus) bp(GO:macroautophagy)
Jens p(HGNC:ITPKB) path(MESH:"Alzheimer Disease") path(MESH:"Plaque, Amyloid")
Jens a(CHEBI:nicotine) a(MESH:"Dopaminergic Neurons") p(HBP:"alpha-4 beta-2 nAChR")
Jens bp(GO:"microtubule polymerization") p(HGNC:DAPK1) p(HGNC:MAPT)
Jens a(CHEBI:sirolimus) bp(GO:macroautophagy) p(HGNC:SNCA)
Jens p(HGNC:CHRNA7) p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
Jens bp(GO:"microglial cell activation") p(HGNC:IL6) path(MESH:"Alzheimer Disease")
Jens bp(MESH:"Oxidative Stress") p(HGNC:GSK3B) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) p(HGNC:CHRM2)
Jens a(HBP:"amyloid-beta oligomers") p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Thr, 205))
Jens bp(HBP:"protein aggregation") complex(p(HGNC:BAG6), p(HGNC:UBA3)) p(MESH:Proteins, pmod(HBP:misfolding))
Jens a(CHEBI:"amyloid-beta") p(FPLX:JNK) p(HGNC:DKK1)
Jens bp(GO:aging) bp(GO:locomotion) p(HGNC:MAPT)
Jens a(CHEBI:"Hsp90 inhibitor") p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta") bp(MESH:"Neuronal Outgrowth") p(MGI:Chrna7)
Jens a(CHEBI:"D-ribose") a(CHEBI:"advanced glycation end-product") p(MGI:Mapt, pmod(Ph, Ser, 214))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(MESH:Microglia) p(MESH:"I-kappa B Proteins", pmod(Ph))
Jens a(CHEBI:"amyloid-beta") bp(GO:"innate immune response") complex(GO:"NLRP3 inflammasome complex")
Jens a(HBP:"Tau aggregates") a(PUBCHEM:9804992) p(FPLX:HDAC)
Jens bp(MESH:Aging) p(FPLX:HSP90) p(FPLX:Proteasome)
Jens a(MESH:"Embryonic Structures") a(MESH:antalarmin) bp(MESH:"Heat-Shock Response")
Jens a(CHEBI:"amyloid-beta") bp(GO:"neuron death") bp(GO:proteolysis)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") p(HGNC:IDE)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:simvastatin) bp(GO:"apoptotic process")
Jens a(CHEBI:"calcium(2+)") a(CHEBI:"calcium(2+)") a(CHEBI:"calcium(2+)")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(CHEBI:nicotine)
Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine) p(HGNC:ACHE)
Jens a(GO:"neurofibrillary tangle") p(HBP:"CDK5R1 p25") path(MESH:"Alzheimer Disease")
Jens p(HGNC:CDK5) p(HGNC:MAPK1) path(MESH:"Alzheimer Disease")
Jens bp(GO:"apoptotic process") p(FPLX:AKT) p(HGNC:RELA)
Jens bp(GO:"cell death") p(HGNC:RNF19A) p(HGNC:SOD1, var("?"))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:Nilvadipine) complex(GO:"NF-kappaB complex")
Jens a(HBP:"amyloid-beta oligomers") p(FPLX:Proteasome) p(HGNC:MAPT)
Jens p(HGNC:MAPT, pmod(Ac, Lys, 353)) p(HGNC:MAPT, pmod(Ac, Lys, 353)) p(HGNC:MAPT, pmod(Ac, Lys, 353))
Jens complex(GO:"neuron projection") p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") path(HBP:neurotoxicity)
Jens a(CHEBI:galanthamine) p(MGI:App, frag("25_35")) path(MESH:"Spatial Memory")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) path(HBP:neurotoxicity)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:wogonin) bp(GO:autophagy)
Jens a(CHEBI:"reactive oxygen species") complex(GO:"NF-kappaB complex") p(FPLX:PKC)
Jens p(FPLX:NFkappaB) p(HGNC:TNF) path(MESH:"Alzheimer Disease")
Jens bp(GO:aging) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(HBP:"Corticobasal Degeneration")
Jens a(CHEBI:wogonin) bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph))
Jens bp(GO:"chaperone-mediated autophagy") bp(MESH:Aging) path(MESH:"Protein Aggregation, Pathological")
Jens a(CHEBI:Anatabine) a(GO:"myelin sheath") path(MESH:Encephalomyelitis)
Jens bp(GO:"neuron death") complex(GO:"NF-kappaB complex") p(HGNC:BACE1)
Jens a(MESH:"Amyloid beta-Peptides") p(HGNC:APP) path(MESH:"Alzheimer Disease")
Jens p(FPLX:NFkappaB) p(FPLX:NFkappaB) p(HGNC:TNF)
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")
Jens a(GO:lysosome) a(GO:lysosome) path(MESH:"Alzheimer Disease")
Jens p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") p(MGI:"interleukin 1 alpha") p(MGI:"oncostatin M")
Jens p(HGNC:CTSD) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 259)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:Calpeptin) p(HGNC:CAPN1) p(HGNC:HTT, var("?"))
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") a(MESH:Microglia)
Jens a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") path(MESH:"Plaque, Amyloid")
Jens a(CHEBI:nicotine) a(MESH:Neurons) p(MGI:Lynx1)
Jens a(CHEBI:"amyloid-beta") a(MESH:"Cholinesterase Inhibitors") path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 280)) p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Alzheimer Disease")
Jens bp(GO:"neuron death") complex(GO:"protein phosphatase type 2A complex") path(MESH:"Alzheimer Disease")
Jens a(GO:autophagosome) a(GO:lysosome) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) p(HGNC:CHRNA7)
Jens bp(GO:autophagy) p(HGNC:CAPN2) p(HGNC:CAST)
Jens a(HBP:"Tau aggregates") bp(GO:"lysosomal microautophagy") p(HGNC:MAPT, frag("?"))
Jens a(PUBCHEM:16057918) complex(GO:"NF-kappaB complex") p(HGNC:BCL2L1)
Jens bp(GO:macroautophagy) p(MGI:Mapt) p(MGI:Mapt, var("p.Ala152Thr"))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(FPLX:CHRN)
Jens a(HBP:"amyloid-beta aggregates") path(MESH:"Alzheimer Disease") path(MESH:"Plaque, Amyloid")
Jens a(MESH:Lysosomes) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:acetylcholine) bp(GO:"action potential initiation") p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta") bp(GO:"apoptotic process") p(HGNC:CHRNA7)
Jens a(HBP:"Tau oligomers") p(HGNC:MAPT, pmod(Ph)) path(HBP:Neurodegeneration)
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(MGI:Bace1)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") g(HBP:"APOE e4")
Jens bp(HBP:"protein aggregation") complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) p(MESH:Proteins, pmod(HBP:misfolding))
Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates") a(MESH:Autophagosomes)
Jens a(CHEBI:galanthamine) bp(GO:"synaptic transmission, cholinergic") p(HGNC:ACHE)
Jens a(CHEBI:"amyloid-beta") bp(GO:"lysosomal microautophagy") complex(GO:"TOR complex")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:Anatabine) p(HGNC:CHRNA7)
Jens a(CHEBI:"amyloid-beta") a(HP:"interstitial fluid") bp(GO:aging)
Jens a(CHEBI:"amyloid-beta") p(HGNC:RAB5A) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") bp(GO:"axonal transport") path(HBP:Neurodegeneration)
Jens a(CHEBI:"amyloid-beta") p(HGNC:MMP2) path(MESH:"Alzheimer Disease")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 290)) p(HGNC:MAPT, pmod(Ac, Lys, 290)) p(HGNC:MAPT, pmod(Ac, Lys, 290))
Jens a(CHEBI:"amyloid-beta") a(HBP:"Tau epitope, PHF1") p(HGNC:MAPT)
Jens p(FPLX:NFkappaB) p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") complex(GO:"TOR complex")
Jens p(HGNC:MAPT, pmod(Ac, Lys, 174)) p(HGNC:MAPT, pmod(Ph, Thr, 205)) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:Nilvadipine) p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jens a(CHEBI:"amyloid-beta") p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:rivastigmine) p(HGNC:LRP1) path(MESH:"Alzheimer Disease")
Jens a(HBP:"Tau aggregates") p(HGNC:PPID) path(MESH:"Alzheimer Disease")
Jens p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
Jens complex(GO:"protein phosphatase type 2A complex") p(HGNC:SET) path(MESH:"Alzheimer Disease")
Jens a(HBP:HBP00006) p(HBP:HBP00053, var("p.Lys280del")) p(HGNC:MAPT)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7)
Jens a(CHEBI:rivastigmine) p(HGNC:ABCB1) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:galanthamine) bp(GO:"synaptic transmission, cholinergic") path(MESH:Schizophrenia)
Jens a(CHEBI:sirolimus) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:rivastigmine) p(HGNC:ACHE) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNC:CHRNA4)
Jens a(CHEBI:lipid) bp(GO:endocytosis) p(HGNC:RAB5A)
Jens a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:MAPT, pmod(Ph, Ser, 202))
Jens a(CHEBI:"amyloid-beta") p(HGNC:APP) path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:"canonical Wnt signaling pathway") p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu"))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) bp(GO:"neuron death")
Jens p(HGNC:PTGS2) path(MESH:"Alzheimer Disease") path(MESH:Inflammation)
Jens p(HGNC:CDK5) p(HGNC:MAPT, pmod(Ph, Ser, 422)) path(MESH:"Alzheimer Disease")
Jens p(FPLX:ERK) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
Jens bp(GO:endocytosis) p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") p(HGNC:RAB5A)
Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta") path(HBP:neurotoxicity)
Jens a(CHEBI:sirolimus) bp(GO:autophagy) p(HGNC:MAPT)
Jens bp(GO:"chaperone-mediated autophagy") p(MGI:Mapt) p(MGI:Mapt, var("p.Ala152Thr"))
Jens a(CHEBI:dopamine) a(CHEBI:nicotine) p(HGNC:CHRNA7)
Jens a(HBP:"Tau aggregates") complex(GO:"proteasome complex") p(HGNC:MAPT, var("?"))
Jens p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))
Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(CHEBI:rosiglitazone)
Jens bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph)) p(HGNC:PPP2CA)
Jens a(GO:lysosome) a(GO:lysosome) a(GO:lysosome)
Jens bp(GO:autophagy) p(HGNC:MAPT) p(HGNC:SQSTM1)
Jens a(CHEBI:acetylcholine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") path(MESH:"Alzheimer Disease")
Jens a(CHEBI:"amyloid-beta") bp(GO:"MAPK cascade") p(HGNC:CHRM1)
Jens p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Jens complex(p(HGNC:GSK3B), p(HGNC:MAPT)) p(HGNC:MAPT) p(HGNC:MAPT)
Jens a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") bp(GO:"synaptic transmission, cholinergic") p(HGNC:ACHE)
Jens a(CHEBI:"okadaic acid") p(FPLX:PPP2) p(HGNC:MAPT, pmod(Ph))
Jens a(CHEBI:"amyloid-beta") bp(GO:"neuron death") complex(GO:"NF-kappaB complex")
Jens a(GO:"neurofibrillary tangle") p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Increase Mismatch a(CHEBI:"amyloid-beta") p(HGNC:CHRNA3) path(MESH:"Alzheimer Disease")
Increase Mismatch a(CHEBI:"amyloid-beta") p(HGNC:RELA) bp(GO:"apoptotic process")
Increase Mismatch a(CHEBI:"amyloid-beta") p(HGNC:CHRNA4) path(MESH:"Alzheimer Disease")
Increase Mismatch a(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease") p(HGNC:CHRNA7)
Increase Mismatch path(MESH:"Alzheimer Disease") p(HGNC:CTSD) a(GO:autophagosome)
Increase Mismatch path(MESH:"Alzheimer Disease") p(HGNC:CTSD) a(GO:lysosome)
Increase Mismatch path(MESH:"Alzheimer Disease") p(HGNC:MAPT, pmod(Ph, Thr, 231)) p(HGNC:MAPT)
Increase Mismatch path(MESH:"Alzheimer Disease") p(HGNC:MAPT) path(MESH:Dementia)
Increase Mismatch p(HGNC:MAPT) complex(a(GO:microtubule), p(HGNC:MAPT)) a(HBP:"Tau aggregates")
Increase Mismatch p(HGNC:MAPT) bp(GO:neurogenesis) p(HGNC:GSK3B)
Increase Mismatch p(HGNC:MAPT) p(HGNC:MAPT) a(GO:microtubule)
Increase Mismatch p(HGNC:MAPT, pmod(Ph)) bp(GO:cognition) path(MESH:"Alzheimer Disease")
Increase Mismatch a(CHEBI:"reactive oxygen species") p(FPLX:ERK) bp(GO:neurogenesis)
Increase Mismatch a(CHEBI:galanthamine) bp(GO:cognition) a(CHEBI:acetylcholine)
Increase Mismatch p(HGNC:APP, var("?")) bp(GO:endocytosis) path(MESH:"Alzheimer Disease")
Increase Mismatch a(CHEBI:nicotine) bp(GO:cognition) a(CHEBI:acetylcholine)
Increase Mismatch a(MESH:"Cholinesterase Inhibitors") a(CHEBI:acetylcholine) bp(GO:cognition)
Increase Mismatch p(HBP:"APOE e4") p(MGI:Cdk5) p(MGI:Cdk5r1)
Increase Mismatch p(HGNC:CHRM1) bp(GO:cognition) a(CHEBI:acetylcholine)
Increase Mismatch a(CHEBI:"nicotinic acetylcholine receptor agonist") bp(GO:cognition) a(CHEBI:acetylcholine)
Increase Mismatch a(PUBCHEM:9867750) a(CHEBI:acetylcholine) bp(GO:cognition)
Increase Mismatch a(HBP:HBP00030) path(MESH:"Alzheimer Disease") a(CHEBI:"amyloid-beta polypeptide 42")
Increase Mismatch p(HGNC:SQSTM1) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") bp(GO:autophagy)
Increase Mismatch p(FPLX:HSP90) bp(GO:"proteasomal protein catabolic process") bp(GO:autophagy)
Increase Mismatch p(HGNC:STUB1) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub))
Increase Mismatch p(HGNC:HSPB1) bp(GO:"proteasomal protein catabolic process") bp(GO:autophagy)
Increase Mismatch p(HGNC:TFEB) a(CHEBI:"amyloid-beta") bp(GO:macroautophagy)
Increase Mismatch bp(GO:"protein K63-linked ubiquitination") bp(GO:autophagy) complex(GO:"proteasome complex")
Increase Mismatch bp(GO:"proteasomal protein catabolic process") p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub))
Increase Mismatch a(MESH:"Heat-Shock Proteins") bp(GO:autophagy) bp(GO:"proteasomal protein catabolic process")
Increase Mismatch p(INTERPRO:"Heat shock protein 70 family") bp(GO:"proteasomal protein catabolic process") bp(GO:autophagy)
Increase Mismatch a(CHEBI:rolipram) p(HGNC:MAPT) complex(GO:"proteasome complex")
Increase Mismatch p(HGNCGENEFAMILY:Proteasome) p(HGNC:MAPT, pmod(Ub)) p(HGNC:MAPT)
Increase Mismatch complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) p(HGNC:MAPT, pmod(Ph))
Increase Mismatch p(HGNC:DAPK1) p(HGNC:MAPT, pmod(Ph, Ser, 262)) bp(GO:"apoptotic process")
Increase Mismatch p(HGNC:DAPK1) p(HGNC:MAPT, pmod(Ph, Ser, 396)) bp(GO:"apoptotic process")
Increase Mismatch p(HGNC:DAPK1) bp(GO:"apoptotic process") p(HGNC:MAPT, pmod(Ph, Thr, 231))
Decrease Mismatch a(CHEBI:"amyloid-beta") complex(GO:"proteasome complex") a(CHEBI:"amyloid-beta")
Decrease Mismatch path(MESH:"Alzheimer Disease") p(FPLX:CHRN) a(MESH:Brain)
Decrease Mismatch path(MESH:"Alzheimer Disease") p(FPLX:CHRN) a(MESH:Neurons)
Decrease Mismatch path(MESH:"Alzheimer Disease") bp(GO:cognition) a(CHEBI:acetylcholine)
Decrease Mismatch p(HGNC:MAPT) path(HBP:Neurodegeneration) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
Decrease Mismatch p(HGNC:MAPT) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") bp(GO:autophagy)
Decrease Mismatch a(CHEBI:galanthamine) path(MESH:"Alzheimer Disease") p(HGNC:ACHE)
Decrease Mismatch a(PUBCHEM:164676) p(HGNC:RELA) bp(GO:"apoptotic process")
Decrease Mismatch a(CHEBI:donepezil) path(MESH:"Alzheimer Disease") p(HGNC:ACHE)
Decrease Mismatch a(CHEBI:rivastigmine) path(MESH:"Alzheimer Disease") p(HGNC:ACHE)
Decrease Mismatch a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") p(HGNC:ACHE) path(MESH:"Alzheimer Disease")
Decrease Mismatch a(CHEBI:"okadaic acid") p(HGNC:PPME1) complex(GO:"protein phosphatase type 2A complex")
Decrease Mismatch a(CHEBI:"microcystin-LR") p(HGNC:PPME1) complex(GO:"protein phosphatase type 2A complex")
Decrease Mismatch p(HGNC:OTUB1) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ub))
Decrease Mismatch p(HGNC:STIP1) p(HGNC:MAPT) p(FPLX:HSP90)
Decrease Mismatch a(CHEBI:lactacystin) complex(GO:"proteasome complex") p(HGNC:MAPT)
Decrease Mismatch p(HGNC:HTT, var("?")) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") bp(GO:autophagy)
Decrease Mismatch p(HGNC:CDC37) p(HGNC:MAPT) p(FPLX:HSP90)
Decrease Mismatch p(HGNC:USP14) p(HGNC:MAPT) complex(GO:"proteasome complex")
Decrease Mismatch a(CHEBI:tanespimycin) p(HGNC:MAPT) p(FPLX:HSP90)
Decrease Mismatch p(FPLX:mTORC1) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") bp(GO:autophagy)
Decrease Mismatch p(HGNC:LRRK2, var("?")) bp(GO:autophagy) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
Decrease Mismatch a(CHEBI:celastrol) p(HGNC:MAPT) p(FPLX:HSP90)
Decrease Mismatch a(PUBCHEM:14719853) p(HGNC:MAPT) p(FPLX:HSP90)
Decrease Mismatch a(CHEBI:"withaferin A") p(HGNC:MAPT) p(FPLX:HSP90)

Unstable Triplets 125

Like unstable pairs, unstable triplets require additional context to understand their mechanisms of regulation.

Chaotic Triplets
A triplet of nodes that mutually increase each other, such as when A increases B, B increases C, and C increases A.
Dampened Triplets
A triplet of nodes that mutually decreases each other, such as when A decreases B, B decreases C, and C decreases A.
Type Node A Node B Node C
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:APP) p(HGNC:IL1B)
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) a(CHEBI:choline)
Chaotic p(HGNC:GSK3B) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Ser, 404))
Chaotic a(CHEBI:"amyloid-beta") p(FPLX:TLR) p(HGNC:IL1B)
Chaotic a(CHEBI:"amyloid-beta") a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7)
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:dopamine) a(HBP:HBP00093)
Chaotic p(MGI:"interleukin 1 alpha") p(MGI:"oncostatin M") p(MGI:"signal transducer and activator of transcription 3")
Chaotic a(MESH:Neurons) p(HGNC:MAPT) p(HGNC:MAPT)
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:"glutamate(2-)") bp(HBP:Excitotoxicity)
Chaotic a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Chaotic p(HGNC:GSK3B) p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Thr, 205))
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:TNF)
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7)
Chaotic a(CHEBI:nicotine) p(HGNC:CHRNA7) p(HGNC:JAK2)
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) p(HGNC:CHRNA7)
Chaotic a(CHEBI:"amyloid-beta") a(CHEBI:simvastatin) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NLRP3 inflammasome complex") p(HGNC:IL1B)
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:IL6)
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NLRP1 inflammasome complex") p(HGNC:IL1B)
Chaotic a(CHEBI:"amyloid-beta") bp(MESH:"Oxidative Stress") p(HGNC:MAPT)
Chaotic a(CHEBI:acetylcholine) a(CHEBI:nicotine) p(HGNC:CHRNA7)
Chaotic p(FPLX:NFkappaB) p(FPLX:NFkappaB) p(HGNC:IL1B)
Chaotic a(CHEBI:acetylcholine) bp(GO:"membrane depolarization") p(FPLX:CHRN)
Chaotic a(CHEBI:"amyloid-beta") a(MESH:Microglia) p(HGNC:MAPT)
Chaotic a(CHEBI:"amyloid-beta") bp(GO:"JNK cascade") complex(GO:"NF-kappaB complex")
Chaotic a(CHEBI:"amyloid-beta") a(MESH:Microglia) p(HGNC:IL1B)
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Chaotic p(HGNC:GSK3B) p(HGNC:MAPT) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Chaotic complex(p(HGNC:FYN), p(HGNC:MAPT)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") a(HBP:HBP00038) bp(GO:phagocytosis)
Chaotic a(CHEBI:"amyloid-beta polypeptide 42") bp(GO:phagocytosis) p(HGNC:TREM2)
Chaotic a(CHEBI:"reactive oxygen species") bp(GO:"inflammatory response") complex(GO:"NF-kappaB complex")
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") complex(a(GO:"membrane attack complex"), p(HGNC:C5))
Chaotic a(CHEBI:"amyloid-beta") bp(GO:"Fas signaling pathway") complex(GO:"NF-kappaB complex")
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:BACE1)
Chaotic a(CHEBI:"amyloid-beta") p(FPLX:NFkappaB) p(HGNC:IL1B)
Chaotic a(CHEBI:nicotine) p(FPLX:PI3K) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Chaotic a(CHEBI:"amyloid-beta") bp(GO:autophagy) p(HGNC:MAPK8)
Chaotic a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:IL1B) p(HGNC:NFKB1)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:BACE1) p(HGNC:RELA)
Chaotic a(CHEBI:nicotine) p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:nicotine) p(HGNC:CHRNA7)
Chaotic p(HGNC:FKBP5) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:CASP1) p(HGNC:IL1B)
Chaotic a(GO:"neurofibrillary tangle") p(HGNC:MAPT, pmod(Ph)) p(HGNC:TNF)
Chaotic p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:SQSTM1)
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) p(FPLX:CHRN)
Chaotic a(MESH:Proteins) a(MESH:Proteins) p(HGNC:PSMD14)
Chaotic a(CHEBI:"amyloid-beta") bp(GO:"MAPK cascade") p(HGNC:TNF)
Chaotic complex(GO:"filamentous actin") p(HGNC:MAPT) p(HGNC:MAPT)
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"inflammasome complex") p(HGNC:IL18)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:AGER) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") a(HBP:HBP00038) complex(GO:"NLRP3 inflammasome complex")
Chaotic a(MESH:Microglia) complex(GO:"NF-kappaB complex") p(HGNC:TNF)
Chaotic a(CHEBI:"amyloid-beta") bp(GO:"MAPK cascade") p(HGNC:CHRNA7)
Chaotic a(CHEBI:acetylcholine) a(CHEBI:galanthamine) p(HGNC:CHRNA7)
Chaotic a(CHEBI:"amyloid-beta") p(FPLX:JNK) p(HGNC:DKK1)
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"inflammasome complex") p(HGNC:IL1B)
Chaotic p(MGI:"interleukin 1 alpha") p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") p(MGI:"oncostatin M")
Chaotic a(CHEBI:"amyloid-beta") bp(GO:"innate immune response") complex(GO:"NLRP3 inflammasome complex")
Chaotic a(HBP:"Tau oligomers") p(HGNC:MAPT) path(MESH:"Brain Injuries, Traumatic")
Chaotic p(HGNC:CDK2) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Chaotic p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") p(MGI:"interleukin 1 alpha") path(MESH:Glioblastoma)
Chaotic a(CHEBI:"glutamate(1-)") a(GO:"excitatory synapse") complex(GO:"NF-kappaB complex")
Chaotic a(CHEBI:nicotine) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") bp(GO:"ERK1 and ERK2 cascade")
Chaotic a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine) a(MESH:"Receptors, Nicotinic")
Chaotic a(CHEBI:"calcium(2+)") a(MESH:"Receptors, Nicotinic") p(HGNC:CHRNA7)
Chaotic a(HBP:"Tau aggregates") p(HGNC:MAPT, frag("?")) path(MESH:Tauopathies)
Chaotic a(CHEBI:"reactive oxygen species") bp(GO:"inflammatory response") p(FPLX:NFkappaB)
Chaotic a(CHEBI:"amyloid-beta polypeptide 42") complex(GO:"NF-kappaB complex") p(HGNC:BACE1)
Chaotic a(CHEBI:"reactive oxygen species") complex(GO:"NF-kappaB complex") p(FPLX:PKC)
Chaotic p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") p(MGI:"oncostatin M") path(MESH:Glioblastoma)
Chaotic p(HGNC:APP, frag("672_713")) p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") bp(GO:phagocytosis) complex(GO:"NLRP3 inflammasome complex")
Chaotic a(CHEBI:"amyloid-beta") a(MESH:Microglia) bp(GO:phagocytosis)
Chaotic a(CHEBI:"amyloid-beta") p(FPLX:NFkappaB) p(HGNC:BACE1)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:CASP1) p(HGNC:IL18)
Chaotic p(FPLX:NFkappaB) p(FPLX:NFkappaB) p(HGNC:TNF)
Chaotic a(CHEBI:nicotine) a(MESH:"SNARE Proteins") p(HGNC:CHRNA7)
Chaotic bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") p(HGNC:MAPT) p(HGNC:SQSTM1)
Chaotic p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") p(MGI:"interleukin 1 alpha") p(MGI:"oncostatin M")
Chaotic a(MESH:Microglia) complex(GO:"NF-kappaB complex") p(HGNC:IL6)
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:IL1B)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:APP) p(HGNC:DKK1)
Chaotic p(HGNC:FYN) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:nicotine) a(MESH:Neurons) p(MGI:Lynx1)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:MAPK14) p(HGNC:RELA)
Chaotic bp(GO:"response to misfolded protein") p(HGNC:ERN1) p(HGNC:XBP1)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:APP) p(HGNC:WNT3A)
Chaotic p(HGNC:CDK1) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:APOE) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:acetylcholine) bp(GO:"action potential initiation") p(HGNC:CHRNA7)
Chaotic bp(GO:"MAPK cascade") p(FPLX:NFkappaB) p(HGNC:TNF)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:MMP2) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") bp(MESH:"Oxidative Stress") complex(GO:"NF-kappaB complex")
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NLRP1 inflammasome complex") p(HGNC:IL18)
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") complex(GO:"calcium- and calmodulin-dependent protein kinase complex")
Chaotic p(HGNC:AK1) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
Chaotic a(HBP:"Tau oligomers") p(HGNC:MAPT) p(HGNC:MAPT)
Chaotic a(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine) p(HGNC:CHRNA7)
Chaotic p(FPLX:ERK) p(FPLX:NFkappaB) p(HGNC:TNF)
Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NLRP3 inflammasome complex") p(HGNC:IL18)
Chaotic a(CHEBI:"calcium(2+)") p(HGNC:MAPT) p(HGNCGENEFAMILY:Calpains)
Chaotic a(CHEBI:"amyloid-beta") bp(GO:"response to oxidative stress") bp(GO:autophagy)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:APP) path(MESH:"Alzheimer Disease")
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:BACE1) p(HGNC:TNF)
Chaotic bp(GO:autophagy) p(HGNC:SQSTM1) p(MESH:Proteins, pmod(HBP:misfolding))
Chaotic a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7) p(HGNC:CHRNA7)
Chaotic a(CHEBI:"amyloid-beta") bp(GO:"inflammatory response") p(HGNC:DKK1)
Chaotic bp(GO:autophagy) p(HGNC:MAPT) p(HGNC:SQSTM1)
Chaotic a(CHEBI:acetylcholine) bp(GO:"membrane depolarization") p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Chaotic a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT) p(HGNC:MAPT)
Chaotic a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
Dampened a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:BCL2L1)
Dampened a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") a(CHEBI:nicotine)
Dampened p(HBP:"cis p-tau") p(HBP:"cis p-tau") p(HGNC:PIN1)
Dampened a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
Dampened a(CHEBI:"amyloid-beta") complex(GO:"NF-kappaB complex") p(HGNC:BCL2L1)
Dampened a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:CHRNA7)
Dampened a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta") p(HGNC:CHRM1)

Causal Pathologies 336

Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.

Source Relation Target
path(HBP:"high-fat prenatal maternal diet") increases a(CHEBI:"amyloid-beta")
path(HBP:"isolation rearing") increases p(RGD:Drd2)
path(HBP:"isolation rearing") increases p(RGD:Drd3)
path(HBP:"isolation rearing") decreases r(RGD:Bdnf)
path(HBP:"isolation rearing") increases r(RGD:Bdnf)
path(HBP:"isolation rearing") decreases r(RGD:Ntrk2)
path(HBP:"isolation rearing") increases r(RGD:Ntrk2)
path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"amyloid-beta")
path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species")
path(HBP:"mitochondrial dysfunction") decreases a(CHEBI:ATP)
path(HBP:"mitochondrial dysfunction") increases p(HGNC:MAPT)
path(HP:"Ischemic stroke") increases complex(GO:"NF-kappaB complex")
path(HP:Seizures) increases complex(GO:"NF-kappaB complex")
path(MESH:"Alcohol Drinking") decreases p(HGNC:ADNP)
path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP)
path(MESH:"Alcohol Drinking") decreases p(HGNC:TFAP2B)
path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP)
path(MESH:"Alzheimer Disease") decreases a(CHEBI:"amyloid-beta")
path(MESH:"Alzheimer Disease") increases a(CHEBI:"amyloid-beta")
path(MESH:"Alzheimer Disease") increases a(CHEBI:"iron(0)")
path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin)
path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine)
path(MESH:"Alzheimer Disease") decreases a(CHEBI:water)
path(MESH:"Alzheimer Disease") increases a(GO:autolysosome)
path(MESH:"Alzheimer Disease") increases a(GO:autophagosome)
path(MESH:"Alzheimer Disease") increases a(GO:lysosome)
path(MESH:"Alzheimer Disease") increases a(HBP:"Tau oligomers")
path(MESH:"Alzheimer Disease") decreases a(HBP:"alpha-4 beta-2 nAChR")
path(MESH:"Alzheimer Disease") increases a(HBP:HBP00018)
path(MESH:"Alzheimer Disease") increases a(MESH:"Basal Nucleus of Meynert")
path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")
path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinesterase Inhibitors")
path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles")
path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes)
path(MESH:"Alzheimer Disease") decreases a(MESH:Brain)
path(MESH:"Alzheimer Disease") decreases a(MESH:Neurons)
path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRM))
path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRN))
path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRM))
path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN))
path(MESH:"Alzheimer Disease") increases complex(a(GO:autophagosome), a(HBP:"dystrophic neurite"))
path(MESH:"Alzheimer Disease") decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
path(MESH:"Alzheimer Disease") increases complex(p(HGNC:ESR1), p(HGNC:MAPT))
path(MESH:"Alzheimer Disease") increases complex(p(HGNC:FYN), p(HGNC:MAPT))
path(MESH:"Alzheimer Disease") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome))
path(MESH:"Alzheimer Disease") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172))
path(MESH:"Alzheimer Disease") increases p(ECCODE:"3.1.1.89")
path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRM)
path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRN)
path(MESH:"Alzheimer Disease") increases p(FPLX:HSPB)
path(MESH:"Alzheimer Disease") decreases p(FPLX:PPP2)
path(MESH:"Alzheimer Disease") decreases p(HBP:"alpha-4 beta-2 nAChR")
path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1)
path(MESH:"Alzheimer Disease") increases p(HGNC:ABL1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:ACHE)
path(MESH:"Alzheimer Disease") decreases p(HGNC:ACLY)
path(MESH:"Alzheimer Disease") increases p(HGNC:AGER)
path(MESH:"Alzheimer Disease") increases p(HGNC:AGRN)
path(MESH:"Alzheimer Disease") increases p(HGNC:AK1)
path(MESH:"Alzheimer Disease") increases p(HGNC:ANP32A)
path(MESH:"Alzheimer Disease") increases p(HGNC:APP)
path(MESH:"Alzheimer Disease") decreases p(HGNC:ATAD2)
path(MESH:"Alzheimer Disease") increases p(HGNC:ATP1A1)
path(MESH:"Alzheimer Disease") increases p(HGNC:BACE1)
path(MESH:"Alzheimer Disease") increases p(HGNC:BAX)
path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE)
path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1)
path(MESH:"Alzheimer Disease") increases p(HGNC:BGN)
path(MESH:"Alzheimer Disease") increases p(HGNC:BRCA1)
path(MESH:"Alzheimer Disease") increases p(HGNC:CADPS2)
path(MESH:"Alzheimer Disease") decreases p(HGNC:CANX)
path(MESH:"Alzheimer Disease") increases p(HGNC:CAPN1)
path(MESH:"Alzheimer Disease") increases p(HGNC:CAPN2)
path(MESH:"Alzheimer Disease") increases p(HGNC:CCNB1)
path(MESH:"Alzheimer Disease") increases p(HGNC:CDK1)
path(MESH:"Alzheimer Disease") increases p(HGNC:CDK2)
path(MESH:"Alzheimer Disease") increases p(HGNC:CDKN2A)
path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT)
path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3)
path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4)
path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7)
path(MESH:"Alzheimer Disease") increases p(HGNC:CHRNA7)
path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNB4)
path(MESH:"Alzheimer Disease") increases p(HGNC:CRYAB)
path(MESH:"Alzheimer Disease") increases p(HGNC:CTSD)
path(MESH:"Alzheimer Disease") increases p(HGNC:CXCR4)
path(MESH:"Alzheimer Disease") decreases p(HGNC:DHCR24)
path(MESH:"Alzheimer Disease") increases p(HGNC:EIF4EBP1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:FGF2)
path(MESH:"Alzheimer Disease") decreases p(HGNC:FKBP4)
path(MESH:"Alzheimer Disease") increases p(HGNC:FKBP5)
path(MESH:"Alzheimer Disease") increases p(HGNC:FOLH1)
path(MESH:"Alzheimer Disease") increases p(HGNC:FYN)
path(MESH:"Alzheimer Disease") decreases p(HGNC:GABRB3)
path(MESH:"Alzheimer Disease") decreases p(HGNC:GCNT2)
path(MESH:"Alzheimer Disease") increases p(HGNC:GLRX)
path(MESH:"Alzheimer Disease") increases p(HGNC:HMOX1)
path(MESH:"Alzheimer Disease") increases p(HGNC:HOMER1)
path(MESH:"Alzheimer Disease") increases p(HGNC:HRH1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:HSP90AB1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA14)
path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA8)
path(MESH:"Alzheimer Disease") increases p(HGNC:HSPB1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:HTRA1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE)
path(MESH:"Alzheimer Disease") increases p(HGNC:IGF2)
path(MESH:"Alzheimer Disease") increases p(HGNC:IGFBP2)
path(MESH:"Alzheimer Disease") increases p(HGNC:IL6R)
path(MESH:"Alzheimer Disease") increases p(HGNC:ITPKB)
path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1)
path(MESH:"Alzheimer Disease") increases p(HGNC:LDLR)
path(MESH:"Alzheimer Disease") decreases p(HGNC:LRP1)
path(MESH:"Alzheimer Disease") increases p(HGNC:MAOA)
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPK1)
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT)
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, frag("?"))
path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 259))
path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 290))
path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 321))
path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 353))
path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(OGlyco))
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph))
path(MESH:"Alzheimer Disease") regulates p(HGNC:MAPT, pmod(Ph))
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
path(MESH:"Alzheimer Disease") decreases p(HGNC:MME)
path(MESH:"Alzheimer Disease") decreases p(HGNC:MMP1)
path(MESH:"Alzheimer Disease") increases p(HGNC:MMP2)
path(MESH:"Alzheimer Disease") increases p(HGNC:NEFH)
path(MESH:"Alzheimer Disease") decreases p(HGNC:NFE2L2)
path(MESH:"Alzheimer Disease") increases p(HGNC:NPDC1)
path(MESH:"Alzheimer Disease") increases p(HGNC:NPTX1)
path(MESH:"Alzheimer Disease") increases p(HGNC:NQO1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:NR3C1)
path(MESH:"Alzheimer Disease") increases p(HGNC:NRGN)
path(MESH:"Alzheimer Disease") increases p(HGNC:PHF1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:PPARA)
path(MESH:"Alzheimer Disease") decreases p(HGNC:PPID)
path(MESH:"Alzheimer Disease") decreases p(HGNC:PPP5C)
path(MESH:"Alzheimer Disease") increases p(HGNC:PREP)
path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCB)
path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCD)
path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKCE)
path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKDC)
path(MESH:"Alzheimer Disease") increases p(HGNC:PROS1)
path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS1)
path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS2)
path(MESH:"Alzheimer Disease") increases p(HGNC:RANBP9)
path(MESH:"Alzheimer Disease") decreases p(HGNC:SCD)
path(MESH:"Alzheimer Disease") increases p(HGNC:SELENBP1)
path(MESH:"Alzheimer Disease") increases p(HGNC:SET)
path(MESH:"Alzheimer Disease") decreases p(HGNC:SIRT1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:SLC6A6)
path(MESH:"Alzheimer Disease") increases p(HGNC:SOD1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:SYVN1)
path(MESH:"Alzheimer Disease") increases p(HGNC:TAGLN)
path(MESH:"Alzheimer Disease") decreases p(HGNC:TCP1)
path(MESH:"Alzheimer Disease") increases p(HGNC:TGFB1)
path(MESH:"Alzheimer Disease") increases p(HGNC:TGM2)
path(MESH:"Alzheimer Disease") decreases p(HGNC:TSHZ1)
path(MESH:"Alzheimer Disease") decreases p(HGNC:TUBB)
path(MESH:"Alzheimer Disease") increases p(HGNC:TUBB3)
path(MESH:"Alzheimer Disease") decreases p(HGNC:TXN)
path(MESH:"Alzheimer Disease") decreases p(HGNC:UNG)
path(MESH:"Alzheimer Disease") increases p(HGNC:VKORC1)
path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
path(MESH:"Alzheimer Disease") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")
path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")
path(MESH:"Alzheimer Disease") decreases p(MESH:Neprilysin)
path(MESH:"Alzheimer Disease") increases p(MGI:Il6)
path(MESH:"Alzheimer Disease") increases p(MGI:Stat3, pmod(Ph))
path(MESH:"Alzheimer Disease") increases p(MGI:Tnf)
path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem")
path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts")
path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A)
path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system")
path(MESH:"Brain Injuries, Traumatic") increases complex(GO:"NF-kappaB complex")
path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4)
path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT)
path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10)
path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5)
path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9)
path(MESH:"Cerebral Infarction") increases complex(GO:"NF-kappaB complex")
path(MESH:"Colorectal Neoplasms") decreases p(HGNC:ABCD3)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:ACLY)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:ANTXR1)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:C20orf27)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:CCNA2)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:CHAF1A)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:DHFR)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:EFCAB11)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:FEN1)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:GINS2)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:GLRX2)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM10)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM4)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:MICB)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:NQO1)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:RNASEH2A)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:SLIT2)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:SPC25)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:TFRC)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:TK1)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:TMEM97)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:TRIP13)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB3)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:TYMS)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:UBA1)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:UNG)
path(MESH:"Colorectal Neoplasms") increases p(HGNC:VRK1)
path(MESH:"Down Syndrome") increases a(HBP:HBP00018)
path(MESH:"Frontotemporal Dementia") increases p(HGNC:ABL1)
path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD)
path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB)
path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1)
path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB)
path(MESH:"Huntington Disease") decreases p(HGNC:HSP90AB1)
path(MESH:"Huntington Disease") decreases p(HGNC:HSPA14)
path(MESH:"Huntington Disease") decreases p(HGNC:HSPA8)
path(MESH:"Huntington Disease") decreases p(HGNC:TCP1)
path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10)
path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5)
path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9)
path(MESH:"Parkinson Disease") increases a(CHEBI:"iron(0)")
path(MESH:"Parkinson Disease") decreases a(MESH:"Dopaminergic Neurons")
path(MESH:"Prion Diseases") increases a(HBP:"amyloid-beta aggregates")
path(MESH:"Protein Aggregation, Pathological") decreases p(HGNC:HSPA8)
path(MESH:"Proteostasis Deficiencies") decreases p(MGI:Mapt, var("p.Pro301Leu"))
path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2))
path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP)
path(MESH:"Spinal Cord Injuries") increases complex(GO:"NLRP1 inflammasome complex")
path(MESH:"Spinal Cord Injuries") increases p(HGNC:IL18)
path(MESH:"Spinal Cord Injuries") increases p(HGNC:IL1B)
path(MESH:"Stress Disorders, Traumatic") increases p(MESH:"corticotropin releasing factor-binding protein")
path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle")
path(MESH:"Supranuclear Palsy, Progressive") increases a(HBP:HBP00045)
path(MESH:"Supranuclear Palsy, Progressive") increases p(ECCODE:"3.1.1.89")
path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1)
path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1)
path(MESH:"Supranuclear Palsy, Progressive") increases r(HBP:"TGM2 Isoform 3 (349 aa)")
path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1)
path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2)
path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL1R2)
path(MESH:"Tobacco Use Disorder") increases a(HBP:"alpha-4 beta-2 nAChR")
path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex")
path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3)
path(MESH:"Vitamin B Deficiency") decreases p(FPLX:PPP2, pmod(Me))
path(MESH:"Vitamin B Deficiency") increases p(HGNC:APP, pmod(Ph))
path(MESH:"Vitamin B Deficiency") increases p(HGNC:MAPT, pmod(Ph))
path(MESH:Aging) increases a(GO:"cytoplasmic vesicle")
path(MESH:Aging) decreases a(MESH:"Cerebrospinal Fluid")
path(MESH:Aging) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
path(MESH:Aging) increases p(MESH:"Membrane Transport Proteins")
path(MESH:Aging) decreases p(MESH:"Mitogen-Activated Protein Kinases")
path(MESH:Aging) decreases p(MGI:Chrna4)
path(MESH:Aging) increases p(MGI:Hif1an)
path(MESH:Aging) increases p(MGI:Nfkb1)
path(MESH:Atherosclerosis) increases p(HGNC:CTNNB1)
path(MESH:Atherosclerosis) increases p(HGNC:DHFR)
path(MESH:Atherosclerosis) increases p(HGNC:EDN1)
path(MESH:Atherosclerosis) increases p(HGNC:EGR1)
path(MESH:Atherosclerosis) increases p(HGNC:ITGB3)
path(MESH:Atherosclerosis) increases p(HGNC:MKI67)
path(MESH:Atherosclerosis) increases p(HGNC:MMP11)
path(MESH:Atherosclerosis) increases p(HGNC:MMP14)
path(MESH:Atherosclerosis) increases p(HGNC:MMP2)
path(MESH:Atherosclerosis) decreases p(HGNC:NR3C1)
path(MESH:Atherosclerosis) increases p(HGNC:PDE7A)
path(MESH:Atherosclerosis) increases p(HGNC:PDE7B)
path(MESH:Atherosclerosis) increases p(HGNC:PLAU)
path(MESH:Atherosclerosis) decreases p(HGNC:PPARA)
path(MESH:Atherosclerosis) increases p(HGNC:PTGS1)
path(MESH:Atherosclerosis) increases p(HGNC:PTGS2)
path(MESH:Atherosclerosis) increases p(HGNC:SCARB1)
path(MESH:Atherosclerosis) increases p(HGNC:SOAT1)
path(MESH:Atherosclerosis) increases p(HGNC:TUBB3)
path(MESH:D000544) decreases a(HBP:"3R tau")
path(MESH:D000544) decreases a(MESH:D059329)
path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
path(MESH:D000544) increases g(HGNC:NGFR)
path(MESH:D000544) decreases g(HGNC:NTRK1)
path(MESH:D000544) decreases g(HGNC:NTRK2)
path(MESH:D000544) decreases g(HGNC:NTRK3)
path(MESH:D000544) decreases p(HGNC:ACHE)
path(MESH:D000544) increases p(HGNC:BCHE)
path(MESH:D000544) decreases p(HGNC:CHAT)
path(MESH:D000544) increases p(HGNC:MMP9)
path(MESH:D000544) increases p(HGNC:NGF)
path(MESH:D000544) decreases p(HGNC:NTRK1)
path(MESH:D000544) increases r(HGNC:CHRNA7)
path(MESH:D000544) increases r(HGNC:CTSD)
path(MESH:D000544) decreases r(HGNC:PPP1CA)
path(MESH:D000544) decreases r(HGNC:PPP1CC)
path(MESH:D000544) decreases r(HGNC:SYP)
path(MESH:D003704) decreases p(HGNC:ACHE)
path(MESH:D060825) decreases a(HBP:"3R tau")
path(MESH:D060825) decreases a(MESH:D013569)
path(MESH:D060825) increases p(HGNC:CHAT)
path(MESH:D060825) increases p(HGNC:MMP9)
path(MESH:Depression) increases a(CHEBI:choline)
path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath")
path(MESH:Encephalomyelitis) increases a(MESH:Leukocytes)
path(MESH:Encephalomyelitis) increases a(MESH:Microglia)
path(MESH:Encephalomyelitis) increases p(MGI:Ifng)
path(MESH:Encephalomyelitis) increases p(MGI:Il1b)
path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph))
path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph))
path(MESH:Encephalomyelitis) increases p(MGI:Tnf)
path(MESH:Fasting) decreases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation"))
path(MESH:Fasting) increases p(MGI:Mapt, pmod(Ph))
path(MESH:Fear) increases a(CHEBI:dopamine)
path(MESH:Glioblastoma) increases p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")
path(MESH:Glioblastoma) increases p(MGI:"chitinase-like 1")
path(MESH:Hypoxia) increases complex(GO:"NF-kappaB complex")
path(MESH:Inflammation) increases p(HGNC:MAPT, pmod(Ph))
path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins")
path(MESH:Schizophrenia) increases a(MESH:Hippocampus)
path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7)
path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta")
path(MESH:Sleep) increases a(MESH:"Blood-Brain Barrier")
path(MESH:Smoking) increases a(MESH:"Blood Glucose")
path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein"))
path(MESH:Starvation) increases p(HGNC:MAPT)
path(MESH:Starvation) increases p(HGNC:TFEB)
path(MESH:Starvation) increases p(HGNC:WDFY3)
path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid")))
path(MESH:Stroke) increases complex(GO:"inflammasome complex")
path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?"))
path(MESH:Tauopathies) increases p(MGI:Ctsd)
path(MESH:Tauopathies) increases p(MGI:Lamp1)
path(MESH:Tauopathies) increases p(MGI:Tfeb)